Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	formyltetrahydrofolate dehydrogenase activity	ALDH1L2 ALDH1L1	1.11e-05	2	67	2	GO:0016155
GeneOntologyMolecularFunction	active transmembrane transporter activity	ABCA4 ABCA12 SLC6A17 SLC16A14 SLC22A4 SLCO1B3 NDUFA5 SLC4A5	1.90e-04	477	67	8	GO:0022804
GeneOntologyMolecularFunction	pyrophosphatase activity	ABCA4 FBH1 GNA14 ABCA12 LRRK2 GNAS MTREX DDX24 REM2 ITPA	4.59e-04	839	67	10	GO:0016462
GeneOntologyMolecularFunction	hydrolase activity, acting on acid anhydrides	ABCA4 FBH1 GNA14 ABCA12 LRRK2 GNAS MTREX DDX24 REM2 ITPA	4.64e-04	840	67	10	GO:0016817
GeneOntologyMolecularFunction	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	ABCA4 FBH1 GNA14 ABCA12 LRRK2 GNAS MTREX DDX24 REM2 ITPA	4.64e-04	840	67	10	GO:0016818
GeneOntologyMolecularFunction	transmembrane transporter activity	SLC41A2 SLC7A1 ABCA4 TRPM3 ABCA12 SLC6A17 SLC16A14 SLC22A4 SLCO1B3 ATP5MF NDUFA5 SLC4A5	5.01e-04	1180	67	12	GO:0022857
GeneOntologyMolecularFunction	protein tag activity	UBB UBC	9.83e-04	14	67	2	GO:0031386
GeneOntologyMolecularFunction	molecular tag activity	UBB UBC	9.83e-04	14	67	2	GO:0141047
GeneOntologyMolecularFunction	ribonucleoside triphosphate phosphatase activity	ABCA4 FBH1 GNA14 ABCA12 LRRK2 GNAS MTREX DDX24 REM2	1.09e-03	775	67	9	GO:0017111
GeneOntologyMolecularFunction	transporter activity	SLC41A2 SLC7A1 ABCA4 TRPM3 ABCA12 SLC6A17 SLC16A14 SLC22A4 SLCO1B3 ATP5MF NDUFA5 SLC4A5	1.09e-03	1289	67	12	GO:0005215
GeneOntologyMolecularFunction	aldehyde dehydrogenase (NAD+) activity	ALDH1L2 ALDH1L1	1.13e-03	15	67	2	GO:0004029
GeneOntologyMolecularFunction	aldehyde dehydrogenase [NAD(P)+] activity	ALDH1L2 ALDH1L1	1.46e-03	17	67	2	GO:0004030
GeneOntologyMolecularFunction	symporter activity	SLC6A17 SLC16A14 SLC22A4 SLC4A5	1.62e-03	150	67	4	GO:0015293
GeneOntologyMolecularFunction	oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor	ALDH1L2 ALDH1L1	1.64e-03	18	67	2	GO:0016646
GeneOntologyMolecularFunction	lipid transmembrane transporter activity	ABCA4 ABCA12 SLCO1B3	1.90e-03	73	67	3	GO:0170055
GeneOntologyMolecularFunction	amine binding	HTR1A ADRB1	2.24e-03	21	67	2	GO:0043176
GeneOntologyMolecularFunction	adrenergic receptor binding	ADRB1 GNAS	2.92e-03	24	67	2	GO:0031690
GeneOntologyMolecularFunction	syntaxin-1 binding	LRRK2 UNC13A	2.92e-03	24	67	2	GO:0017075
GeneOntologyMolecularFunction	secondary active transmembrane transporter activity	SLC6A17 SLC16A14 SLC22A4 SLCO1B3 SLC4A5	3.16e-03	296	67	5	GO:0015291
GeneOntologyMolecularFunction	G-protein beta/gamma-subunit complex binding	GNA14 GNAS	3.17e-03	25	67	2	GO:0031683
GeneOntologyMolecularFunction	ATPase-coupled intramembrane lipid transporter activity	ABCA4 ABCA12	3.96e-03	28	67	2	GO:0140326
GeneOntologyMolecularFunction	transferase activity, transferring phosphorus-containing groups	PIKFYVE FLT3 VRK2 LATS2 POLM NEK8 LRRK2 UBA6 NMRK1	3.97e-03	938	67	9	GO:0016772
GeneOntologyBiologicalProcess	10-formyltetrahydrofolate catabolic process	ALDH1L2 ALDH1L1	2.93e-05	3	65	2	GO:0009258
GeneOntologyBiologicalProcess	cellular response to dopamine	HTR1A GNA14 LRRK2 GNAS	4.95e-05	64	65	4	GO:1903351
GeneOntologyBiologicalProcess	response to dopamine	HTR1A GNA14 LRRK2 GNAS	5.59e-05	66	65	4	GO:1903350
GeneOntologyBiologicalProcess	cellular response to monoamine stimulus	HTR1A GNA14 LRRK2 GNAS	6.29e-05	68	65	4	GO:0071868
GeneOntologyBiologicalProcess	cellular response to catecholamine stimulus	HTR1A GNA14 LRRK2 GNAS	6.29e-05	68	65	4	GO:0071870
GeneOntologyBiologicalProcess	response to catecholamine	HTR1A GNA14 LRRK2 GNAS	8.30e-05	73	65	4	GO:0071869
GeneOntologyBiologicalProcess	response to monoamine	HTR1A GNA14 LRRK2 GNAS	8.76e-05	74	65	4	GO:0071867
GeneOntologyBiologicalProcess	purine nucleotide metabolic process	GPD2 NADSYN1 ALDH1L2 LRRK2 NMRK1 ATP5MF ALDH1L1 NDUFA5 ITPA	1.33e-04	619	65	9	GO:0006163
GeneOntologyBiologicalProcess	10-formyltetrahydrofolate metabolic process	ALDH1L2 ALDH1L1	1.45e-04	6	65	2	GO:0009256
GeneOntologyBiologicalProcess	purine-containing compound metabolic process	GPD2 NADSYN1 ALDH1L2 LRRK2 NMRK1 ATP5MF ALDH1L1 NDUFA5 ITPA	1.96e-04	652	65	9	GO:0072521
GeneOntologyBiologicalProcess	folic acid-containing compound catabolic process	ALDH1L2 ALDH1L1	2.03e-04	7	65	2	GO:0009397
GeneOntologyBiologicalProcess	pteridine-containing compound catabolic process	ALDH1L2 ALDH1L1	2.03e-04	7	65	2	GO:0042560
GeneOntologyBiologicalProcess	nucleotide metabolic process	GPD2 NADSYN1 ALDH1L2 LRRK2 NMRK1 ATP5MF ALDH1L1 NDUFA5 ITPA	2.80e-04	684	65	9	GO:0009117
GeneOntologyBiologicalProcess	nucleoside phosphate metabolic process	GPD2 NADSYN1 ALDH1L2 LRRK2 NMRK1 ATP5MF ALDH1L1 NDUFA5 ITPA	3.02e-04	691	65	9	GO:0006753
GeneOntologyBiologicalProcess	G protein-coupled dopamine receptor signaling pathway	GNA14 LRRK2 GNAS	3.61e-04	44	65	3	GO:0007212
GeneOntologyBiologicalProcess	nicotinamide nucleotide metabolic process	GPD2 NADSYN1 ALDH1L2 NMRK1 ALDH1L1	4.40e-04	202	65	5	GO:0046496
GeneOntologyBiologicalProcess	pyridine nucleotide metabolic process	GPD2 NADSYN1 ALDH1L2 NMRK1 ALDH1L1	4.40e-04	202	65	5	GO:0019362
GeneOntologyCellularComponent	mitochondrial membrane	SLC25A46 GPD2 UBB VRK2 UBC ABCA12 NLRX1 SLC22A4 LRRK2 ATP5MF RTN4IP1 MRPL3 NDUFA5	2.58e-06	866	66	13	GO:0031966
GeneOntologyCellularComponent	mitochondrial envelope	SLC25A46 GPD2 UBB VRK2 UBC ABCA12 NLRX1 SLC22A4 LRRK2 ATP5MF RTN4IP1 MRPL3 NDUFA5	4.55e-06	912	66	13	GO:0005740
GeneOntologyCellularComponent	mitochondrial outer membrane	SLC25A46 UBB UBC NLRX1 LRRK2 RTN4IP1	1.12e-04	241	66	6	GO:0005741
GeneOntologyCellularComponent	organelle envelope	SLC25A46 GPD2 UBB VRK2 UBC ABCA12 NLRX1 SLC22A4 NUP210 LRRK2 ATP5MF RTN4IP1 MRPL3 NDUFA5	1.28e-04	1435	66	14	GO:0031967
GeneOntologyCellularComponent	organelle outer membrane	SLC25A46 UBB UBC NLRX1 LRRK2 RTN4IP1	2.49e-04	279	66	6	GO:0031968
GeneOntologyCellularComponent	outer membrane	SLC25A46 UBB UBC NLRX1 LRRK2 RTN4IP1	2.58e-04	281	66	6	GO:0019867
Domain	10_FTHF_DH	ALDH1L2 ALDH1L1	1.19e-05	2	65	2	IPR011407
Domain	GART_AS	ALDH1L2 ALDH1L1	3.57e-05	3	65	2	IPR001555
Domain	Formyl_trans_C	ALDH1L2 ALDH1L1	3.57e-05	3	65	2	PF02911
Domain	Formyl_trans_C	ALDH1L2 ALDH1L1	3.57e-05	3	65	2	IPR005793
Domain	GART	ALDH1L2 ALDH1L1	3.57e-05	3	65	2	PS00373
Domain	-	ALDH1L2 ALDH1L1	3.57e-05	3	65	2	3.10.25.10
Domain	Formyl_trans_N	ALDH1L2 ALDH1L1	7.12e-05	4	65	2	PF00551
Domain	-	ALDH1L2 ALDH1L1	7.12e-05	4	65	2	3.40.50.170
Domain	Formyl_transf_N	ALDH1L2 ALDH1L1	7.12e-05	4	65	2	IPR002376
Domain	-	ALDH1L2 ALDH1L1	1.18e-04	5	65	2	1.10.1200.10
Domain	PP-binding	ALDH1L2 ALDH1L1	1.18e-04	5	65	2	PF00550
Domain	ACP_DOMAIN	ALDH1L2 ALDH1L1	1.18e-04	5	65	2	PS50075
Domain	PHOSPHOPANTETHEINE	ALDH1L2 ALDH1L1	1.18e-04	5	65	2	PS00012
Domain	Formyl_transferase_C-like	ALDH1L2 ALDH1L1	1.18e-04	5	65	2	IPR011034
Domain	PP-bd_ACP	ALDH1L2 ALDH1L1	1.77e-04	6	65	2	IPR009081
Domain	-	ABCA4 FBH1 GNA14 ABCA12 LRRK2 NMRK1 GNAS MTREX DDX24 REM2	2.38e-04	746	65	10	3.40.50.300
Domain	UBIQUITIN_1	UBB UBC RAD23A	2.87e-04	37	65	3	PS00299
Domain	UBQ	UBB UBC RAD23A	4.49e-04	43	65	3	SM00213
Domain	Ubiquitin_CS	UBB UBC	5.27e-04	10	65	2	IPR019954
Domain	ubiquitin	UBB UBC RAD23A	5.85e-04	47	65	3	PF00240
Domain	Ubiquitin	UBB UBC	6.43e-04	11	65	2	IPR019956
Domain	P-loop_NTPase	ABCA4 FBH1 GNA14 ABCA12 LRRK2 NMRK1 GNAS MTREX DDX24 REM2	6.55e-04	848	65	10	IPR027417
Domain	FAD-dep_OxRdtase	GPD2 SQLE	7.70e-04	12	65	2	IPR006076
Domain	ABC_A	ABCA4 ABCA12	7.70e-04	12	65	2	IPR026082
Domain	DAO	GPD2 SQLE	7.70e-04	12	65	2	PF01266
Domain	UBIQUITIN_2	UBB UBC RAD23A	8.79e-04	54	65	3	PS50053
Domain	Ubiquitin_dom	UBB UBC RAD23A	1.08e-03	58	65	3	IPR000626
Domain	G-alpha	GNA14 GNAS	1.39e-03	16	65	2	PF00503
Domain	GproteinA_insert	GNA14 GNAS	1.39e-03	16	65	2	IPR011025
Domain	-	GNA14 GNAS	1.39e-03	16	65	2	1.10.400.10
Domain	Ald_DH_CS_GLU	ALDH1L2 ALDH1L1	1.39e-03	16	65	2	IPR029510
Domain	G_alpha	GNA14 GNAS	1.39e-03	16	65	2	SM00275
Domain	Ald_DH_CS_CYS	ALDH1L2 ALDH1L1	1.57e-03	17	65	2	IPR016160
Domain	Gprotein_alpha_su	GNA14 GNAS	1.57e-03	17	65	2	IPR001019
Domain	ALDEHYDE_DEHYDR_GLU	ALDH1L2 ALDH1L1	1.76e-03	18	65	2	PS00687
Domain	ALDEHYDE_DEHYDR_CYS	ALDH1L2 ALDH1L1	1.76e-03	18	65	2	PS00070
Domain	Ald_DH_C	ALDH1L2 ALDH1L1	1.96e-03	19	65	2	IPR016163
Domain	Ald_DH_N	ALDH1L2 ALDH1L1	1.96e-03	19	65	2	IPR016162
Domain	Ald_DH/histidinol_DH	ALDH1L2 ALDH1L1	1.96e-03	19	65	2	IPR016161
Domain	-	ALDH1L2 ALDH1L1	1.96e-03	19	65	2	3.40.605.10
Domain	Aldedh	ALDH1L2 ALDH1L1	1.96e-03	19	65	2	PF00171
Domain	Aldehyde_DH_dom	ALDH1L2 ALDH1L1	1.96e-03	19	65	2	IPR015590
Domain	-	ALDH1L2 ALDH1L1	1.96e-03	19	65	2	3.40.309.10
Domain	MFS	SLC16A14 SLC22A4 SLCO1B3	6.33e-03	108	65	3	PS50850
Pathway	REACTOME_FLT3_SIGNALING_BY_CBL_MUTANTS	FLT3 UBB UBC	1.37e-06	7	49	3	M41737
Pathway	REACTOME_JOSEPHIN_DOMAIN_DUBS	UBB UBC RAD23A	8.49e-06	12	49	3	M27577
Pathway	REACTOME_JOSEPHIN_DOMAIN_DUBS	UBB UBC RAD23A	8.49e-06	12	49	3	MM15288
Pathway	REACTOME_NEGATIVE_REGULATORS_OF_DDX58_IFIH1_SIGNALING	UBB UBC NLRX1	1.40e-05	14	49	3	MM15642
Pathway	REACTOME_TRANSPORT_OF_SMALL_MOLECULES	SLC41A2 SLC7A1 UBB UBC ABCA4 TRPM3 ABCA12 SLC22A4 SLCO1B3 GNAS SLC4A5	1.67e-05	681	49	11	MM14985
Pathway	REACTOME_NEGATIVE_REGULATION_OF_FLT3	FLT3 UBB UBC	1.74e-05	15	49	3	M41735
Pathway	REACTOME_REGULATION_OF_NF_KAPPA_B_SIGNALING	UBB UBC NLRX1	2.59e-05	17	49	3	MM15702
Pathway	REACTOME_REGULATION_OF_NF_KAPPA_B_SIGNALING	UBB UBC NLRX1	3.10e-05	18	49	3	M45023
Pathway	REACTOME_TRANSPORT_OF_SMALL_MOLECULES	SLC41A2 SLC7A1 UBB UBC ABCA4 TRPM3 ABCA12 SLC22A4 SLCO1B3 GNAS SLC4A5	3.43e-05	736	49	11	M27287
Pathway	REACTOME_ER_QUALITY_CONTROL_COMPARTMENT_ERQC	UBB UBC	7.07e-05	4	49	2	MM15591
Pathway	KEGG_MEDICUS_REFERENCE_UCHL1_MEDIATED_HYDROLYSIS	UBB UBC	1.18e-04	5	49	2	M49036
Pathway	REACTOME_FLT3_SIGNALING_IN_DISEASE	FLT3 UBB UBC	1.22e-04	28	49	3	M41724
Pathway	REACTOME_SYNTHESIS_OF_ACTIVE_UBIQUITIN_ROLES_OF_E1_AND_E2_ENZYMES	UBB UBC UBA6	1.50e-04	30	49	3	M27762
Pathway	REACTOME_SYNTHESIS_OF_ACTIVE_UBIQUITIN_ROLES_OF_E1_AND_E2_ENZYMES	UBB UBC UBA6	1.50e-04	30	49	3	MM15507
Pathway	REACTOME_DDX58_IFIH1_MEDIATED_INDUCTION_OF_INTERFERON_ALPHA_BETA	UBB UBC NLRX1	2.00e-04	33	49	3	MM14666
Pathway	REACTOME_NEGATIVE_REGULATORS_OF_DDX58_IFIH1_SIGNALING	UBB UBC NLRX1	2.39e-04	35	49	3	M985
Pathway	REACTOME_REGULATION_OF_EXPRESSION_OF_SLITS_AND_ROBOS	UBB UBC	2.46e-04	7	49	2	MM15593
Pathway	REACTOME_CALNEXIN_CALRETICULIN_CYCLE	UBB UBC	2.46e-04	7	49	2	MM15592
Pathway	REACTOME_MODULATION_BY_MTB_OF_HOST_IMMUNE_SYSTEM	UBB UBC	2.46e-04	7	49	2	M29822
Pathway	REACTOME_DNA_DAMAGE_RECOGNITION_IN_GG_NER	UBB UBC RAD23A	3.06e-04	38	49	3	M27592
Pathway	REACTOME_DNA_DAMAGE_RECOGNITION_IN_GG_NER	UBB UBC RAD23A	3.06e-04	38	49	3	MM15301
Pathway	REACTOME_FLT3_SIGNALING	FLT3 UBB UBC	3.06e-04	38	49	3	M29803
Pathway	REACTOME_TAK1_DEPENDENT_IKK_AND_NF_KAPPA_B_ACTIVATION	UBB UBC NLRX1	3.30e-04	39	49	3	MM15116
Pathway	REACTOME_DISORDERS_OF_TRANSMEMBRANE_TRANSPORTERS	UBB UBC ABCA12 NUP210 SLCO1B3	3.60e-04	177	49	5	M27476
Pathway	REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT	UBB UBC ABCA4 ABCA12	3.81e-04	99	49	4	MM14986
Pathway	REACTOME_PTK6_REGULATES_RTKS_AND_THEIR_EFFECTORS_AKT1_AND_DOK1	UBB UBC	4.20e-04	9	49	2	M27732
Pathway	REACTOME_INLA_MEDIATED_ENTRY_OF_LISTERIA_MONOCYTOGENES_INTO_HOST_CELLS	UBB UBC	4.20e-04	9	49	2	M27781
Pathway	REACTOME_DOWNREGULATION_OF_ERBB4_SIGNALING	UBB UBC	4.20e-04	9	49	2	M26930
Pathway	REACTOME_REGULATION_OF_PTEN_LOCALIZATION	UBB UBC	4.20e-04	9	49	2	M27814
Pathway	REACTOME_SCF_BETA_TRCP_MEDIATED_DEGRADATION_OF_EMI1	UBB UBC	4.20e-04	9	49	2	MM14676
Pathway	REACTOME_PREVENTION_OF_PHAGOSOMAL_LYSOSOMAL_FUSION	UBB UBC	4.20e-04	9	49	2	M29819
Pathway	REACTOME_MYOCLONIC_EPILEPSY_OF_LAFORA	UBB UBC	4.20e-04	9	49	2	M27276
Pathway	REACTOME_PTK6_REGULATES_RTKS_AND_THEIR_EFFECTORS_AKT1_AND_DOK1	UBB UBC	4.20e-04	9	49	2	MM15482
Pathway	REACTOME_DOWNREGULATION_OF_ERBB4_SIGNALING	UBB UBC	4.20e-04	9	49	2	MM14535
Pathway	REACTOME_FORMATION_OF_INCISION_COMPLEX_IN_GG_NER	UBB UBC RAD23A	4.42e-04	43	49	3	M1005
Pathway	REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT	UBB UBC ABCA4 ABCA12	4.42e-04	103	49	4	M758
Pathway	REACTOME_TAK1_DEPENDENT_IKK_AND_NF_KAPPA_B_ACTIVATION	UBB UBC NLRX1	4.73e-04	44	49	3	M852
Pathway	REACTOME_FORMATION_OF_INCISION_COMPLEX_IN_GG_NER	UBB UBC RAD23A	5.05e-04	45	49	3	MM15302
Pathway	REACTOME_REGULATION_OF_PTEN_LOCALIZATION	UBB UBC	5.23e-04	10	49	2	MM15539
Pathway	REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS	UBB UBC	5.23e-04	10	49	2	MM14849
Pathway	REACTOME_IRAK2_MEDIATED_ACTIVATION_OF_TAK1_COMPLEX	UBB UBC	5.23e-04	10	49	2	MM15647
Pathway	REACTOME_IRAK2_MEDIATED_ACTIVATION_OF_TAK1_COMPLEX	UBB UBC	5.23e-04	10	49	2	M27925
Pathway	REACTOME_SIGNALING_BY_PTK6	UBB UBC LRRK2	6.12e-04	48	49	3	MM15479
Pathway	REACTOME_REGULATION_OF_TBK1_IKK_MEDIATED_ACTIVATION_OF_IRF3_IRF7_UPON_TLR3_LIGATION	UBB UBC	6.38e-04	11	49	2	M48241
Pathway	REACTOME_REGULATION_OF_BACH1_ACTIVITY	UBB UBC	6.38e-04	11	49	2	M41833
Pathway	REACTOME_ALPHA_PROTEIN_KINASE_1_SIGNALING_PATHWAY	UBB UBC	6.38e-04	11	49	2	M29827
Pathway	REACTOME_PEXOPHAGY	UBB UBC	6.38e-04	11	49	2	M29846
Pathway	REACTOME_TICAM1_TRAF6_DEPENDENT_INDUCTION_OF_TAK1_COMPLEX	UBB UBC	6.38e-04	11	49	2	M27885
Pathway	REACTOME_ALPHA_PROTEIN_KINASE_1_SIGNALING_PATHWAY	UBB UBC	6.38e-04	11	49	2	MM15668
Pathway	REACTOME_PEXOPHAGY	UBB UBC	6.38e-04	11	49	2	MM15673
Pathway	REACTOME_REGULATION_OF_BACH1_ACTIVITY	UBB UBC	6.38e-04	11	49	2	MM15686
Pathway	REACTOME_DOWNREGULATION_OF_ERBB2_ERBB3_SIGNALING	UBB UBC	7.64e-04	12	49	2	MM14550
Pathway	REACTOME_METABOLISM_OF_WATER_SOLUBLE_VITAMINS_AND_COFACTORS	NADSYN1 ALDH1L2 NMRK1 ALDH1L1	7.87e-04	120	49	4	MM14771
Pathway	REACTOME_SIGNALING_BY_PTK6	UBB UBC LRRK2	8.64e-04	54	49	3	M29742
Pathway	REACTOME_P75NTR_RECRUITS_SIGNALLING_COMPLEXES	UBB UBC	9.01e-04	13	49	2	MM14827
Pathway	REACTOME_NF_KB_IS_ACTIVATED_AND_SIGNALS_SURVIVAL	UBB UBC	9.01e-04	13	49	2	MM14828
Pathway	REACTOME_MAP3K8_TPL2_DEPENDENT_MAPK1_3_ACTIVATION	UBB UBC	9.01e-04	13	49	2	MM15280
Pathway	REACTOME_DOWNREGULATION_OF_ERBB2_ERBB3_SIGNALING	UBB UBC	9.01e-04	13	49	2	M549
Pathway	REACTOME_SUPPRESSION_OF_PHAGOSOMAL_MATURATION	UBB UBC	9.01e-04	13	49	2	M29823
Pathway	REACTOME_REGULATION_OF_INNATE_IMMUNE_RESPONSES_TO_CYTOSOLIC_DNA	UBB UBC	9.01e-04	13	49	2	MM14931
Pathway	REACTOME_P75NTR_RECRUITS_SIGNALLING_COMPLEXES	UBB UBC	9.01e-04	13	49	2	M14582
Pathway	REACTOME_TICAM1_DEPENDENT_ACTIVATION_OF_IRF3_IRF7	UBB UBC	9.01e-04	13	49	2	M27884
Pathway	REACTOME_TRAF6_MEDIATED_IRF7_ACTIVATION_IN_TLR7_8_OR_9_SIGNALING	UBB UBC	9.01e-04	13	49	2	M967
Pathway	REACTOME_NF_KB_IS_ACTIVATED_AND_SIGNALS_SURVIVAL	UBB UBC	9.01e-04	13	49	2	M736
Pathway	REACTOME_METABOLISM_OF_WATER_SOLUBLE_VITAMINS_AND_COFACTORS	NADSYN1 ALDH1L2 NMRK1 ALDH1L1	9.73e-04	127	49	4	M27093
Pathway	REACTOME_REGULATION_OF_TBK1_IKK_IKBKE_MEDIATED_ACTIVATION_OF_IRF3_IRF7	UBB UBC	1.05e-03	14	49	2	M48239
Pathway	REACTOME_NRIF_SIGNALS_CELL_DEATH_FROM_THE_NUCLEUS	UBB UBC	1.05e-03	14	49	2	MM14826
Pathway	REACTOME_GLYCOGEN_SYNTHESIS	UBB UBC	1.05e-03	14	49	2	M27247
Pathway	REACTOME_NEGATIVE_REGULATION_OF_FLT3	UBB UBC	1.05e-03	14	49	2	MM15682
Pathway	REACTOME_IRAK1_RECRUITS_IKK_COMPLEX	UBB UBC	1.05e-03	14	49	2	M935
Pathway	KEGG_MEDICUS_REFERENCE_AUTOPHAGY_VESICLE_NUCLEATION_ELONGATION_MATURATION_SEQUESTOSOME_1_LIKE_RECEPTOR	UBB UBC	1.05e-03	14	49	2	M47975
Pathway	REACTOME_INLB_MEDIATED_ENTRY_OF_LISTERIA_MONOCYTOGENES_INTO_HOST_CELL	UBB UBC	1.21e-03	15	49	2	M27774
Pathway	REACTOME_REGULATION_OF_TBK1_IKK_IKBKE_MEDIATED_ACTIVATION_OF_IRF3_IRF7	UBB UBC	1.21e-03	15	49	2	MM17228
Pathway	REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION	UBB UBC	1.21e-03	15	49	2	MM14875
Pathway	REACTOME_REGULATION_OF_INNATE_IMMUNE_RESPONSES_TO_CYTOSOLIC_DNA	UBB UBC	1.21e-03	15	49	2	M27229
Pathway	REACTOME_SIGNALING_BY_NOTCH1_HD_DOMAIN_MUTANTS_IN_CANCER	UBB UBC	1.21e-03	15	49	2	M27202
Pathway	REACTOME_N_GLYCAN_TRIMMING_IN_THE_ER_AND_CALNEXIN_CALRETICULIN_CYCLE	UBB UBC	1.21e-03	15	49	2	MM15175
Pathway	REACTOME_IRAK1_RECRUITS_IKK_COMPLEX	UBB UBC	1.21e-03	15	49	2	MM15645
Pathway	REACTOME_SLC_MEDIATED_TRANSMEMBRANE_TRANSPORT	SLC41A2 SLC7A1 SLC22A4 SLCO1B3 SLC4A5	1.37e-03	238	49	5	MM15076
Pathway	REACTOME_VLDLR_INTERNALISATION_AND_DEGRADATION	UBB UBC	1.38e-03	16	49	2	M27761
Pathway	WP_TRYPTOPHAN_CATABOLISM_LEADING_TO_NAD_PRODUCTION	NADSYN1 NMRK1	1.38e-03	16	49	2	M39752
Pathway	REACTOME_MAP3K8_TPL2_DEPENDENT_MAPK1_3_ACTIVATION	UBB UBC	1.38e-03	16	49	2	M27567
Pathway	REACTOME_NRIF_SIGNALS_CELL_DEATH_FROM_THE_NUCLEUS	UBB UBC	1.38e-03	16	49	2	M7257
Pathway	REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING	UBB UBC	1.38e-03	16	49	2	MM14873
Pathway	REACTOME_VLDLR_INTERNALISATION_AND_DEGRADATION	UBB UBC	1.38e-03	16	49	2	MM15506
Pathway	REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION	UBB UBC	1.38e-03	16	49	2	M627
Pathway	REACTOME_TRAF6_MEDIATED_INDUCTION_OF_TAK1_COMPLEX_WITHIN_TLR4_COMPLEX	UBB UBC	1.38e-03	16	49	2	M1000
Pathway	REACTOME_ONCOGENE_INDUCED_SENESCENCE	UBB UBC	1.38e-03	16	49	2	MM14903
Pathway	REACTOME_ASSEMBLY_OF_THE_HIV_VIRION	UBB UBC	1.38e-03	16	49	2	M27033
Pathway	REACTOME_GLYCOGEN_STORAGE_DISEASES	UBB UBC	1.38e-03	16	49	2	M27236
Pathway	REACTOME_P75NTR_SIGNALS_VIA_NF_KB	UBB UBC	1.38e-03	16	49	2	M18175
Pathway	REACTOME_P75NTR_SIGNALS_VIA_NF_KB	UBB UBC	1.38e-03	16	49	2	MM14742
Pathway	REACTOME_SPRY_REGULATION_OF_FGF_SIGNALING	UBB UBC	1.38e-03	16	49	2	MM14541
Pathway	REACTOME_SPRY_REGULATION_OF_FGF_SIGNALING	UBB UBC	1.38e-03	16	49	2	M514
Pathway	REACTOME_PROTEIN_UBIQUITINATION	UBB UBC UBA6	1.48e-03	65	49	3	MM15490
Pathway	REACTOME_TRANSLESION_SYNTHESIS_BY_POLK	UBB UBC	1.56e-03	17	49	2	M27537
Pathway	REACTOME_TRANSLESION_SYNTHESIS_BY_POLK	UBB UBC	1.56e-03	17	49	2	MM15259
Pathway	REACTOME_METABOLISM_OF_FOLATE_AND_PTERINES	ALDH1L2 ALDH1L1	1.56e-03	17	49	2	M27085
Pathway	REACTOME_TRAF6_MEDIATED_INDUCTION_OF_TAK1_COMPLEX_WITHIN_TLR4_COMPLEX	UBB UBC	1.56e-03	17	49	2	MM15648
Pathway	REACTOME_SLC_MEDIATED_TRANSMEMBRANE_TRANSPORT	SLC41A2 SLC7A1 SLC22A4 SLCO1B3 SLC4A5	1.67e-03	249	49	5	M5988
Pubmed	Binding of HIV-1 Vpr protein to the human homolog of the yeast DNA repair protein RAD23 (hHR23A) requires its xeroderma pigmentosum complementation group C binding (XPCB) domain as well as the ubiquitin-associated 2 (UBA2) domain.	UBB UBC RAD23A	6.81e-08	5	67	3	24318982
Pubmed	A High-Density Human Mitochondrial Proximity Interaction Network.	SLC25A46 PIKFYVE GPD2 UBB VRK2 LYPLAL1 ALDH1L2 RTN4IP1 ZCCHC17 MRPL3 NDUFA5 GNAS DDX24 ITPA	8.05e-07	1496	67	14	32877691
Pubmed	Recurrent ubiquitin B silencing in gynecological cancers establishes dependence on ubiquitin C.	UBB UBC	3.66e-06	2	67	2	29130934
Pubmed	Structure of ubiquitin refined at 1.8 A resolution.	UBB UBC	3.66e-06	2	67	2	3041007
Pubmed	Cloning of human polyubiquitin cDNAs and a ubiquitin-binding assay involving its in vitro translation product.	UBB UBC	3.66e-06	2	67	2	9644242
Pubmed	Combination of ATO with FLT3 TKIs eliminates FLT3/ITD+ leukemia cells through reduced expression of FLT3.	FLT3 UBC	3.66e-06	2	67	2	30250637
Pubmed	GNAS A-1121G variant is associated with improved diastolic dysfunction in response to exercise training in heart failure patients.	ADRB1 GNAS	3.66e-06	2	67	2	23065660
Pubmed	Effects of polymorphisms in beta1-adrenoceptor and alpha-subunit of G protein on heart rate and blood pressure during exercise test. The Finnish Cardiovascular Study.	ADRB1 GNAS	3.66e-06	2	67	2	16210433
Pubmed	The ubiquitin-proteasome system as a prospective molecular target for cancer treatment and prevention.	UBB UBC	3.66e-06	2	67	2	20491623
Pubmed	Effect of 393T>C polymorphism of GNAS1 gene on dobutamine response in Chinese healthy subjects.	ADRB1 GNAS	3.66e-06	2	67	2	19542315
Pubmed	Hybrid troponin reconstituted from vertebrate and arthropod subunits.	UBB UBC	3.66e-06	2	67	2	124018
Pubmed	Simultaneous Disruption of Both Polyubiquitin Genes Affects Proteasome Function and Decreases Cellular Proliferation.	UBB UBC	3.66e-06	2	67	2	32705536
Pubmed	The human ubiquitin multigene family: some genes contain multiple directly repeated ubiquitin coding sequences.	UBB UBC	3.66e-06	2	67	2	2988935
Pubmed	Structural and biochemical studies of the open state of Lys48-linked diubiquitin.	UBC RAD23A	3.66e-06	2	67	2	22542781
Pubmed	Structural determinants for selective recognition of a Lys48-linked polyubiquitin chain by a UBA domain.	UBC RAD23A	3.66e-06	2	67	2	15949443
Pubmed	Avid interactions underlie the Lys63-linked polyubiquitin binding specificities observed for UBA domains.	UBC RAD23A	3.66e-06	2	67	2	19620964
Pubmed	Structure of a new crystal form of tetraubiquitin.	UBB UBC	3.66e-06	2	67	2	11173499
Pubmed	Interaction of the C9orf72-Amyotrophic Lateral Sclerosis-Related Proline-Arginine Dipeptide Repeat Protein with the RNA-Binding Protein NOVA1 Causes Decreased Expression of UNC13A Due to Enhanced Inclusion of Cryptic Exons, Which Is Reversed by Betulin Treatment.	UNC13A NOVA1	3.66e-06	2	67	2	37887320
Pubmed	Ubiquitination of human immunodeficiency virus type 1 Gag is highly dependent on Gag membrane association.	UBB UBC	3.66e-06	2	67	2	17609272
Pubmed	ALDH1L2 is the mitochondrial homolog of 10-formyltetrahydrofolate dehydrogenase.	ALDH1L2 ALDH1L1	3.66e-06	2	67	2	20498374
Pubmed	Rad23 ubiquitin-associated domains (UBA) inhibit 26 S proteasome-catalyzed proteolysis by sequestering lysine 48-linked polyubiquitin chains.	UBC RAD23A	3.66e-06	2	67	2	12643283
Pubmed	Beta-adrenergic receptor blockade arrests myocyte damage and preserves cardiac function in the transgenic G(salpha) mouse.	ADRB1 GNAS	3.66e-06	2	67	2	10487769
Pubmed	LRRK2 G2019S Induces Anxiety/Depression-like Behavior before the Onset of Motor Dysfunction with 5-HT1A Receptor Upregulation in Mice.	HTR1A LRRK2	3.66e-06	2	67	2	29305532
Pubmed	[Genetic dependency of blood pressure and heart rate in patients with arterial hypertension and obesity].	ADRB1 GNAS	3.66e-06	2	67	2	25558679
Pubmed	Heterogeneous structure of the polyubiquitin gene UbC of HeLa S3 cells.	UBB UBC	3.66e-06	2	67	2	8917096
Pubmed	The emerging complexity of protein ubiquitination.	UBB UBC	3.66e-06	2	67	2	19754430
Pubmed	Higher frequency of concerted evolutionary events in rodents than in man at the polyubiquitin gene VNTR locus.	UBB UBC	3.66e-06	2	67	2	9504932
Pubmed	Synthetic, structural and biological studies of the ubiquitin system: the total chemical synthesis of ubiquitin.	UBB UBC	3.66e-06	2	67	2	8166633
Pubmed	Lineage-specific homogenization of the polyubiquitin gene among human and great apes.	UBB UBC	3.66e-06	2	67	2	14745543
Pubmed	UBL/UBA ubiquitin receptor proteins bind a common tetraubiquitin chain.	UBC RAD23A	3.66e-06	2	67	2	16405905
Pubmed	Cloning and sequence analysis of a cDNA encoding poly-ubiquitin in human ovarian granulosa cells.	UBB UBC	3.66e-06	2	67	2	2820408
Pubmed	Rescue of neuropsychiatric phenotypes in a mouse model of 16p11.2 duplication syndrome by genetic correction of an epilepsy network hub.	UBB UBC SLC6A17 ATP5MF NDUFA5 GNAS	3.79e-06	215	67	6	36808153
Pubmed	Evidence for distinct functions for human DNA repair factors hHR23A and hHR23B.	UBB UBC RAD23A	5.46e-06	18	67	3	16712842
Pubmed	Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context.	SLC25A46 GPD2 LYPLAL1 ALDH1L2 NLRX1 SLC22A4 ATP5MF RTN4IP1 MRPL3 ALDH1L1 NDUFA5	1.04e-05	1136	67	11	34800366
Pubmed	Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.	SLC25A46 GPD2 ALDH1L2 NLRX1 SLC22A4 ATP5MF RTN4IP1 MRPL3 ALDH1L1 NDUFA5	1.07e-05	926	67	10	20877624
Pubmed	Acyl carrier protein-specific 4'-phosphopantetheinyl transferase activates 10-formyltetrahydrofolate dehydrogenase.	ALDH1L2 ALDH1L1	1.10e-05	3	67	2	19933275
Pubmed	Structural basis of E2-25K/UBB+1 interaction leading to proteasome inhibition and neurotoxicity.	UBB UBC	1.10e-05	3	67	2	20826778
Pubmed	Polymorphisms of genes CYP2D6, ADRB1 and GNAS1 in pharmacokinetics and systemic effects of ophthalmic timolol. A pilot study.	ADRB1 GNAS	1.10e-05	3	67	2	16315032
Pubmed	Similarities and differences in the coupling of human beta1- and beta2-adrenoceptors to Gs(alpha) splice variants.	ADRB1 GNAS	1.10e-05	3	67	2	12106601
Pubmed	Modulation of HIV-1 Rev protein abundance and activity by polyubiquitination with unconventional Lys-33 branching.	UBB UBC	1.10e-05	3	67	2	17067581
Pubmed	Specificity of the E1-E2-E3 enzymatic cascade for ubiquitin C-terminal sequences identified by phage display.	UBC UBA6	1.10e-05	3	67	2	23003343
Pubmed	Components of the ubiquitin-proteasome pathway compete for surfaces on Rad23 family proteins.	UBC RAD23A	1.10e-05	3	67	2	18234089
Pubmed	The Ubiquitin Gene Expression Pattern and Sensitivity to UBB and UBC Knockdown Differentiate Primary 23132/87 and Metastatic MKN45 Gastric Cancer Cells.	UBB UBC	1.10e-05	3	67	2	32751694
Pubmed	Cumulative mutations of ubiquitin acceptor sites in human immunodeficiency virus type 1 gag cause a late budding defect.	UBB UBC	1.10e-05	3	67	2	16775314
Pubmed	Characterization of two polyubiquitin binding sites in the 26 S protease subunit 5a.	UBB UBC	1.10e-05	3	67	2	9488668
Pubmed	Identification of cardiac autoantigens in human heart cDNA libraries using acute rheumatic fever sera.	GNAS RAD23A	1.10e-05	3	67	2	8037842
Pubmed	Structure of tetraubiquitin shows how multiubiquitin chains can be formed.	UBB UBC	1.10e-05	3	67	2	8107144
Pubmed	Ubiquitin Chains Bearing Genetically Encoded Photo-Cross-Linkers Enable Efficient Covalent Capture of (Poly)ubiquitin-Binding Domains.	UBC RAD23A	1.10e-05	3	67	2	30668904
Pubmed	Analysis of human immunodeficiency virus type 1 Gag ubiquitination.	UBB UBC	1.10e-05	3	67	2	15994808
Pubmed	Ubiquitin recognition by the DNA repair protein hHR23a.	UBC RAD23A	1.10e-05	3	67	2	14621999
Pubmed	A ubiquitin-interacting motif from Hrs binds to and occludes the ubiquitin surface necessary for polyubiquitination in monoubiquitinated proteins.	UBB UBC	1.10e-05	3	67	2	12207904
Pubmed	Differential regulation of EGF receptor internalization and degradation by multiubiquitination within the kinase domain.	UBB UBC	1.10e-05	3	67	2	16543144
Pubmed	Structure of S5a bound to monoubiquitin provides a model for polyubiquitin recognition.	UBB UBC	1.10e-05	3	67	2	15826667
Pubmed	Disruption of polyubiquitin gene Ubc leads to attenuated resistance against arsenite-induced toxicity in mouse embryonic fibroblasts.	UBB UBC	1.10e-05	3	67	2	25701757
Pubmed	Perturbation of the hematopoietic system during embryonic liver development due to disruption of polyubiquitin gene Ubc in mice.	UBB UBC	1.10e-05	3	67	2	22393459
Pubmed	Direct binding of the beta1 adrenergic receptor to the cyclic AMP-dependent guanine nucleotide exchange factor CNrasGEF leads to Ras activation.	ADRB1 GNAS	1.10e-05	3	67	2	12391161
Pubmed	Defining how ubiquitin receptors hHR23a and S5a bind polyubiquitin.	UBC RAD23A	1.10e-05	3	67	2	17408689
Pubmed	Kinetic Constraints in the Specific Interaction between Phosphorylated Ubiquitin and Proteasomal Shuttle Factors.	UBC RAD23A	1.10e-05	3	67	2	34356632
Pubmed	Overexpression of three ubiquitin genes in mouse epidermal tumors is associated with enhanced cellular proliferation and stress.	UBB UBC	1.10e-05	3	67	2	1321656
Pubmed	Enzymatic properties of ALDH1L2, a mitochondrial 10-formyltetrahydrofolate dehydrogenase.	ALDH1L2 ALDH1L1	1.10e-05	3	67	2	21238436
Pubmed	The proteomic reactor facilitates the analysis of affinity-purified proteins by mass spectrometry: application for identifying ubiquitinated proteins in human cells.	UBB UBC HTR1A	1.18e-05	23	67	3	17203973
Pubmed	LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.	SLC7A1 VRK2 UBC TM9SF2 IFT74 NUP210 ATP5MF NDUFA5 GCN1 PHGDH	1.24e-05	942	67	10	31073040
Pubmed	Ubiquilin 2 modulates ALS/FTD-linked FUS-RNA complex dynamics and stress granule formation.	UBB ALDH1L2 ALDH1L1 GNAS GCN1 PHGDH	1.36e-05	269	67	6	30442662
Pubmed	Novel, gel-free proteomics approach identifies RNF5 and JAMP as modulators of GPCR stability.	UBB UBC NUP210 NDUFA5 GNAS	1.48e-05	160	67	5	23798571
Pubmed	Proteomic analysis identifies novel binding partners of BAP1.	ALDH1L2 ALDH1L1 GNAS GCN1	1.78e-05	80	67	4	34591877
Pubmed	Late assembly domain function can exhibit context dependence and involves ubiquitin residues implicated in endocytosis.	UBB UBC	2.19e-05	4	67	2	11991975
Pubmed	Ubiquitin is covalently attached to the p6Gag proteins of human immunodeficiency virus type 1 and simian immunodeficiency virus and to the p12Gag protein of Moloney murine leukemia virus.	UBB UBC	2.19e-05	4	67	2	9525617
Pubmed	Alpha-synuclein has an altered conformation and shows a tight intermolecular interaction with ubiquitin in Lewy bodies.	UBB UBC	2.19e-05	4	67	2	11603807
Pubmed	Overexpression of ubiquilin decreases ubiquitination and degradation of presenilin proteins.	UBC RAD23A	2.19e-05	4	67	2	15004330
Pubmed	Crystal structure of a UBP-family deubiquitinating enzyme in isolation and in complex with ubiquitin aldehyde.	UBB UBC	2.19e-05	4	67	2	12507430
Pubmed	Retroviruses have differing requirements for proteasome function in the budding process.	UBB UBC	2.19e-05	4	67	2	12610113
Pubmed	Histone deacetylase 6 binds polyubiquitin through its zinc finger (PAZ domain) and copurifies with deubiquitinating enzymes.	UBB UBC	2.19e-05	4	67	2	12354939
Pubmed	Human immunodeficiency virus type 1 Vif induces cell cycle delay via recruitment of the same E3 ubiquitin ligase complex that targets APOBEC3 proteins for degradation.	UBB UBC	2.19e-05	4	67	2	18596088
Pubmed	Unique structural, dynamical, and functional properties of k11-linked polyubiquitin chains.	UBC RAD23A	2.19e-05	4	67	2	23823328
Pubmed	Requirements for the interaction of mouse Polkappa with ubiquitin and its biological significance.	UBB UBC	2.19e-05	4	67	2	18162470
Pubmed	L41Q polymorphism of the G protein coupled receptor kinase 5 is associated with left ventricular apical ballooning syndrome.	ADRB1 GNAS	2.19e-05	4	67	2	20023040
Pubmed	Ubiquitination of HIV-1 and MuLV Gag.	UBB UBC	2.19e-05	4	67	2	11112487
Pubmed	The immunosuppressive properties of the HIV Vpr protein are linked to a single highly conserved residue, R90.	UBB UBC	2.19e-05	4	67	2	19516896
Pubmed	A role for ubiquitin ligase recruitment in retrovirus release.	UBB UBC	2.19e-05	4	67	2	11087860
Pubmed	Proteasome inhibition interferes with gag polyprotein processing, release, and maturation of HIV-1 and HIV-2.	UBB UBC	2.19e-05	4	67	2	11087859
Pubmed	Ubiquitin-mediated sequestration of normal cellular proteins into polyglutamine aggregates.	UBB UBC	2.19e-05	4	67	2	12857950
Pubmed	Locus coeruleus neurons are resistant to dysfunction and degeneration by maintaining free ubiquitin levels although total ubiquitin levels decrease upon disruption of polyubiquitin gene Ubb.	UBB UBC	2.19e-05	4	67	2	22285186
Pubmed	A mitochondrial protein compendium elucidates complex I disease biology.	SLC25A46 GPD2 ALDH1L2 NLRX1 SLC22A4 ATP5MF RTN4IP1 MRPL3 ALDH1L1 NDUFA5	3.07e-05	1047	67	10	18614015
Pubmed	Single-Cell Transcriptomics in Medulloblastoma Reveals Tumor-Initiating Progenitors and Oncogenic Cascades during Tumorigenesis and Relapse.	LATS2 GNAS	3.64e-05	5	67	2	31474569
Pubmed	PINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase activity.	UBB UBC	3.64e-05	5	67	2	24751536
Pubmed	Probing protein ubiquitination in live cells.	UBC RAD23A	3.64e-05	5	67	2	36189882
Pubmed	C9orf72 and UNC13A are shared risk loci for amyotrophic lateral sclerosis and frontotemporal dementia: a genome-wide meta-analysis.	SQLE UNC13A	3.64e-05	5	67	2	24931836
Pubmed	The ubiquitin-proteasome pathway is required for the function of the viral VP16 transcriptional activation domain.	UBC RAD23A	3.64e-05	5	67	2	14706819
Pubmed	The role of viral and cellular proteins in the budding of human immunodeficiency virus.	UBB UBC	3.64e-05	5	67	2	16808324
Pubmed	Disentangling the Roles of RIM and Munc13 in Synaptic Vesicle Localization and Neurotransmission.	ABCA4 UNC13A	3.64e-05	5	67	2	33139401
Pubmed	Functional regulation of FEZ1 by the U-box-type ubiquitin ligase E4B contributes to neuritogenesis.	UBB UBC	3.64e-05	5	67	2	15466860
Pubmed	Probing affinity and ubiquitin linkage selectivity of ubiquitin-binding domains using mass spectrometry.	UBC RAD23A	3.64e-05	5	67	2	22428841
Pubmed	Regulation of Pax3 by proteasomal degradation of monoubiquitinated protein in skeletal muscle progenitors.	UBB RAD23A	3.64e-05	5	67	2	17662948
Pubmed	Mixed-linkage ubiquitin chains send mixed messages.	UBC RAD23A	3.64e-05	5	67	2	23562397
Pubmed	The deubiquitinating enzyme USP2a regulates the p53 pathway by targeting Mdm2.	UBB UBC	5.46e-05	6	67	2	17290220
Pubmed	Recognition and cleavage of related to ubiquitin 1 (Rub1) and Rub1-ubiquitin chains by components of the ubiquitin-proteasome system.	UBC RAD23A	5.46e-05	6	67	2	23105008
Pubmed	The transition zone protein Rpgrip1l regulates proteasomal activity at the primary cilium.	UBB UBC	5.46e-05	6	67	2	26150391
Pubmed	Crystal structure of the ubiquitin binding domains of rabex-5 reveals two modes of interaction with ubiquitin.	UBB UBC	5.46e-05	6	67	2	16499958
Pubmed	Alzheimer disease-specific conformation of hyperphosphorylated paired helical filament-Tau is polyubiquitinated through Lys-48, Lys-11, and Lys-6 ubiquitin conjugation.	UBB UBC	5.46e-05	6	67	2	16443603
Pubmed	p62, a phosphotyrosine-independent ligand of the SH2 domain of p56lck, belongs to a new class of ubiquitin-binding proteins.	UBB UBC	5.46e-05	6	67	2	8702753
Cytoband	12p12	SLCO1B3 PLEKHA5	1.62e-04	13	67	2	12p12
Cytoband	Ensembl 112 genes in cytogenetic band chr9q21	GNA14 TRPM3 NMRK1 GCNT1	2.12e-04	199	67	4	chr9q21
Cytoband	2q34	PIKFYVE ABCA12	7.74e-04	28	67	2	2q34
Cytoband	12q23.3	SLC41A2 ALDH1L2	1.21e-03	35	67	2	12q23.3
GeneFamily	Solute carriers	SLC25A46 SLC41A2 SLC7A1 SLC6A17 SLC16A14 SLC22A4 SLCO1B3 SLC4A5	4.31e-06	395	44	8	752
GeneFamily	ATP binding cassette subfamily A	ABCA4 ABCA12	5.17e-04	14	44	2	805
GeneFamily	Aldehyde dehydrogenases	ALDH1L2 ALDH1L1	9.64e-04	19	44	2	398
ToppCell	cellseq-Epithelial-Epithelial_Glandular-Serous\|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	ALDH1L2 SLC16A14 ALDH1L1 GNAS PHGDH	8.52e-06	184	67	5	f0cbb5b76e092be4188a9804ef5cf7a83cd7644f
ToppCell	cellseq-Epithelial-Epithelial_Glandular-Serous-Serous\|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	ALDH1L2 SLC16A14 ALDH1L1 GNAS PHGDH	8.52e-06	184	67	5	5433ba7bbab553ff668619822d1a9208e15cd59f
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ABCA4 TRPM3 CFAP221 LRRK2 NOVA1	8.98e-06	186	67	5	f0c8de4f6ae9047b9108a47a2af8c5f42bc103b0
ToppCell	3'_v3-GI_small-bowel\|World / Manually curated celltypes from each tissue	UBB UBC ADRB1 GNAS DDX24	9.45e-06	188	67	5	822c6abaf7bcd6721269bdbd1f2b286ccf0aec1a
ToppCell	control-Myeloid-mDC\|control / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	GRIP1 SLC41A2 FLT3 ATP5MF MRPL3	1.07e-05	193	67	5	5e43024763932a679c33d83cf8f606612bc0f600
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-10w-Mesenchymal-Cilia-bearing_cell\|10w / Sample Type, Dataset, Time_group, and Cell type.	ABCA4 GNA14 TRPM3 GCNT1 SLC4A5	1.24e-05	199	67	5	2d8ab4aee300c7c4baf662940ce855da2b6d2cae
ToppCell	severe-CD8+_Tem\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	UBB UBC PLEKHA5 GNAS DDX24	1.27e-05	200	67	5	6aa77955017d073a96324e4db6b9950a2ec46cf8
ToppCell	10x5'v1-week_12-13-Hematopoietic-erythroid-late_erythroid\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	NPL UBB SLC22A4 RAD23A	6.60e-05	144	67	4	ca365380ccf5e60d2e3f6272059ff0531759612d
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Cortical_Collecting_Duct_Principal_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	GRIP1 SLC7A1 TRPM3 SLC6A17	7.93e-05	151	67	4	f4f7156b2c0cfc78fd1841e07c9915d97ced561f
ToppCell	Smart-seq2-tissue-resident_(Smart-seq2)-myeloid-myeloid_macrophage-Langerhans_cell\|tissue-resident_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	SLC41A2 FLT3 SQLE PLEKHA5	8.56e-05	154	67	4	617ad0929d2ac0eeb7b8d9b0cba687176e684ed0
ToppCell	frontal_cortex-Neuronal-GABAergic_neuron-Sst-Sst_Calb2_Pdlim5\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	HTR1A LATS2 GNA14 SLC16A14	1.02e-04	161	67	4	bf70be1de418615b5442ec684552551edaf1f072
ToppCell	facs-Lung-ENDOMUCIN-18m-Myeloid-myeloid_dendritic_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLT3 LRRK2 UBA6 GCNT1	1.09e-04	164	67	4	54f8f11d2fa899005530c08e7a1ee728c7b0799c
ToppCell	facs-Pancreas-Exocrine-24m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TRPM3 EFR3B WDR17 NOVA1	1.09e-04	164	67	4	b895674ed2df87db8fbfb30b7e31620945588491
ToppCell	droplet-Lung-nan-3m-Myeloid-Ccr7+_Dendritic\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC41A2 FLT3 SQLE EFR3B	1.09e-04	164	67	4	78de403446fe0eb375c82ff1832cc5fbb8e20afa
ToppCell	10x3'2.3-week_14-16-Hematopoietic-erythroid-late_erythroid\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	NPL UBB GNA14 SLC22A4	1.14e-04	166	67	4	b4e5466a33578103d197cf67f37e7ec88e09281f
ToppCell	severe-Myeloid-mDC\|Myeloid / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	GRIP1 SLC41A2 FLT3 MRPL3	1.20e-04	168	67	4	eff37a92d41624924201372cc09f9eb07b60aec1
ToppCell	PND28-Immune-Immune_Myeloid-DC-cDC2-cDC2_prolif\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SLC41A2 FLT3 CENPL NEK8	1.31e-04	172	67	4	eba1568d4307e91c94fc616549057cbed8df5840
ToppCell	Ionocyte-iono-2\|World / Class top	SLC41A2 GNAS UNC13A CNN3	1.34e-04	173	67	4	e5ec28ccc5e048fd98de4c876e5c53b866b66228
ToppCell	BAL-Control-Myeloid-cDC-cDC-cDC_11\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	SLC41A2 FLT3 TRPM3 PLEKHA5	1.37e-04	174	67	4	991f7eab69ea3ee1045a4e44ce60a96db13df6d1
ToppCell	BAL-Control-Myeloid-cDC-cDC-cDC_11\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	SLC41A2 FLT3 TRPM3 PLEKHA5	1.37e-04	174	67	4	c8cec89369cf3896c5626e447051e76a142cb6df
ToppCell	Fetal_29-31_weeks-Epithelial-club_cell-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	GRIP1 SLC41A2 GNA14 CFAP221	1.43e-04	176	67	4	3bbac5c2397535631fce8fa98f6ddb4fe0260351
ToppCell	PCW_13-14-Hematologic_Myeloid-Hem_Myeloid_dendritic-im_conventional_dendritic_(19)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	SLC41A2 FLT3 NUP210 LRRK2	1.53e-04	179	67	4	9fc44637c9a7551fd47b8533e45a9c199e164a95
ToppCell	droplet-Kidney-nan-18m-Epithelial-nan\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TRPM3 C11orf54 ATP5MF NDUFA5	1.56e-04	180	67	4	cd743f81838ba210e5bb63fe0870918d7d2b0112
ToppCell	COVID-19_Severe-Classical_Monocyte-cMono_1\|COVID-19_Severe / Disease condition and Cell class	FBH1 ATP5MF MTREX GCN1	1.59e-04	181	67	4	0d07a67e8ee3bca687b378afbc4044434e63556d
ToppCell	droplet-Kidney-KIDNEY-1m-Epithelial-epithelial_cell_of_proximal_tubule\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	C11orf54 ATP5MF NDUFA5 GCNT1	1.63e-04	182	67	4	bdeebbfffc1308a29b721a5f8fed23a28d7a2f2f
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_1_/_Segment_2\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	NPL TRPM3 PLEKHA5 ALDH1L1	1.66e-04	183	67	4	facd6dbe0851b537d70a899ac7485714ab27d071
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-3m-Epithelial-Bergmann_glial_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MRO TRPM3 SLC22A4 ALDH1L1	1.66e-04	183	67	4	25c96df8ea0c7bbedbb7699ee84ad6234d19cba8
ToppCell	droplet-Kidney-nan-21m-Epithelial-epithelial_cell_of_proximal_tubule\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NPL C11orf54 LYPLAL1 ATP5MF	1.66e-04	183	67	4	01e7256c9e0ce53f8e10f3d3a5be15dedd312426
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ABCA4 TRPM3 ABCA12 SLC6A17	1.70e-04	184	67	4	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	droplet-Kidney-nan-18m-Epithelial-Epcam____kidney_proximal_convoluted_tubule_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NPL C11orf54 LYPLAL1 GCNT1	1.70e-04	184	67	4	c86ed59fed687cdaaf7e9c4418d2e3e2c4111cca
ToppCell	droplet-Kidney-nan-18m-Epithelial-kidney_proximal_convoluted_tubule_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NPL C11orf54 LYPLAL1 GCNT1	1.70e-04	184	67	4	7c256bcfa07c5ff55aad0833e8712b0456b5832b
ToppCell	droplet-Kidney-nan-21m-Epithelial-Epcam____kidney_proximal_convoluted_tubule_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NPL C11orf54 LYPLAL1 GCNT1	1.70e-04	184	67	4	3d7dd193a0826cc7a4e454a29236a16c315e5965
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ABCA4 TRPM3 ABCA12 SLC6A17	1.70e-04	184	67	4	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ABCA4 TRPM3 ABCA12 SLC6A17	1.70e-04	184	67	4	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	droplet-Kidney-nan-21m-Epithelial-kidney_proximal_convoluted_tubule_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NPL C11orf54 LYPLAL1 GCNT1	1.70e-04	184	67	4	45577ff91c3b2b303acd97239dde2463ea7a429c
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-3m-Epithelial\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MRO TRPM3 SLC22A4 ALDH1L1	1.73e-04	185	67	4	dbbd348714cd16a4948a04648e914b1e71e2a8ef
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-3m-Epithelial-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MRO TRPM3 SLC22A4 ALDH1L1	1.73e-04	185	67	4	bea69058afa5aa927fe15c1f8d46460562ec4dd4
ToppCell	facs-Skin-Anagen-3m-Epithelial-nan\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NPL SLC7A1 ABCA12 SLC22A4	1.77e-04	186	67	4	9a7932d0a208f3997216bd21a72913cc82b59fc9
ToppCell	10x5'-Liver-Myeloid_Dendritic-DC1\|Liver / Manually curated celltypes from each tissue	FLT3 ABCA12 LRRK2 PLEKHA5	1.77e-04	186	67	4	e823529ffd06352c6bdec102f221fdf27f7c7369
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Degenerative_Descending_Thin_Limb_Cell_Type_3\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ABCA4 CFAP221 LRRK2 NOVA1	1.81e-04	187	67	4	c31130fc2f9f882944b2ba366a034a03f051c4b9
ToppCell	facs-Skin-Telogen-3m-Epithelial-basal_cell_of_epidermis\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GNA14 SLC22A4 ALS2CL PHGDH	1.81e-04	187	67	4	9c1013720c248ef201d010806b6e7ad24205e8ee
ToppCell	5'-GW_trimst-2-SmallIntestine-Hematopoietic-Red_blood_cells\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	NPL UBB SLC22A4 RAD23A	1.84e-04	188	67	4	f81099b5b3f1f85a28445bc663efcf73baccb2be
ToppCell	facs-Kidney-nan-3m-Epithelial-kidney_collecting_duct_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	C11orf54 SLC16A14 ATP5MF GCNT1	1.84e-04	188	67	4	b483b4629695764568bcbd1d527d614824147783
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ABCA4 CFAP221 LRRK2 NOVA1	1.84e-04	188	67	4	af740fa78542438fdff627ea1f74f4eee43316be
ToppCell	facs-Kidney-nan-3m-Epithelial-kidney_collecting_duct_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	C11orf54 SLC16A14 ATP5MF GCNT1	1.84e-04	188	67	4	c1f64311ff05093b2f4f672e33f5f75e3bc8a8db
ToppCell	Adult-Epithelial-alveolar_epithelial_cell_type_2-D175\|Adult / Lineage, Cell type, age group and donor	SLC7A1 CFAP221 LRRK2 PHGDH	1.84e-04	188	67	4	ec38def1fdbb34ed9b30244806975bd5a4370164
ToppCell	facs-SCAT-Fat-3m\|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	UBC TM9SF2 ATP5MF MTREX	1.84e-04	188	67	4	b8dff61240e5052c2fbf7f28b86fe41822df45b0
ToppCell	5'-GW_trimst-2-SmallIntestine-Hematopoietic-Red_blood_cells-RBC\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	NPL UBB SLC22A4 RAD23A	1.84e-04	188	67	4	05b3ade422beeb3db73d350fe192c21bfcfef188
ToppCell	facs-Brain_Myeloid-Striatum-3m-Myeloid-nan\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	UBC ADRB1 TM9SF2 MTREX	1.88e-04	189	67	4	6dd4ec5ce4beb856f0d2d1654e3c4676d1d63736
ToppCell	LPS_only-Endothelial-Endothelial-Alv_Gen_Intermediate\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ADRB1 SLC16A14 SLCO1B3 NOVA1	1.88e-04	189	67	4	e82211b9dc7540e7a183be2cbcfae39fdf503949
ToppCell	facs-Brain_Myeloid-Striatum-3m-Myeloid\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	UBC ADRB1 TM9SF2 MTREX	1.88e-04	189	67	4	3ae479ec7e00c57127cbe51a398329b10ca9848c
ToppCell	facs-Brain_Myeloid-Striatum-3m-Myeloid-microglial_cell\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	UBC ADRB1 TM9SF2 MTREX	1.88e-04	189	67	4	875df61ee48baa5142ba4d2427bdec1c53e5a828
ToppCell	facs-Brain_Myeloid-Striatum-3m\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	UBC ADRB1 TM9SF2 MTREX	1.88e-04	189	67	4	97ef5215d841ff366a3e3682cd9bd04100cbfde0
ToppCell	Control-Other\|Control / Disease, Lineage and Cell Type	SLC41A2 UBC TM9SF2 NEK8	1.92e-04	190	67	4	3be5497909b48bf05c623586880f225bb101b430
ToppCell	BAL-Control-Lymphocyte-B-B_cell\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	PIKFYVE SLC7A1 CENPL LRRK2	1.92e-04	190	67	4	da7341a8a423e5fe4d8e733d8e50c10a3318ac1c
ToppCell	Control-Other-RBC\|Control / Disease, Lineage and Cell Type	SLC41A2 UBC TM9SF2 NEK8	1.92e-04	190	67	4	35b254564d01c839c63f9af159a46d368852cf15
ToppCell	BAL-Control-Lymphocyte-B-B_cell-B_cell\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	PIKFYVE SLC7A1 CENPL LRRK2	1.92e-04	190	67	4	42312f7d79fe889397d32910b625793e2535cc26
ToppCell	BAL-Control-Lymphocyte-B-B_cell-B_cell-B_activate-7\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	PIKFYVE SLC7A1 CENPL LRRK2	1.92e-04	190	67	4	682418a7a2096743112eae3790d40e7e600612c0
ToppCell	3'-Broncho-tracheal_SMG-Epithelial-Epithelial_transtional-secretory-SMG_tracheobronchial_serous_cell-SMG_serous_(bronchial)-SMG_serous_(bronchial)_L.0.6.1.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ALDH1L2 SLC16A14 GNAS PHGDH	1.96e-04	191	67	4	13460059a0c1ed9f476cef28b8ad4c06349056c6
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	GRIP1 SLC7A1 TRPM3 SLC16A14	2.00e-04	192	67	4	fd08ae787e936cfdb1ab8f19b0fd63005b462709
ToppCell	TCGA-Stomach-Primary_Tumor-Stomach_Adenocarcinoma-Stomach_Adenocarcinoma_-_NOS-6\|TCGA-Stomach / Sample_Type by Project: Shred V9	GPD2 VRK2 ABCA12 UBA6	2.00e-04	192	67	4	4e689bca7a242f8482e25f273656e2caba8821c0
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Cortical_Collecting_Duct_Principal_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	GRIP1 SLC7A1 TRPM3 SLC16A14	2.00e-04	192	67	4	bae236c9f1fac77bce28d0a9cf090100d391ff77
ToppCell	3'-Broncho-tracheal_SMG-Epithelial-Epithelial_transtional-secretory-SMG_tracheobronchial_serous_cell-SMG_serous_(bronchial)\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ALDH1L2 SLC16A14 GNAS PHGDH	2.04e-04	193	67	4	56145861ef5e7655db9ad0d11b82f72dcadf285d
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Myeloid-Macrophage-macrophage,_alveolar-Macro_c6-VCAN\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	NPL FLT3 SLC22A4 LRRK2	2.04e-04	193	67	4	52f5b0fbb8ca706206c65e7edbb1ddbd380aebae
ToppCell	BAL-Severe-Myeloid-cDC-cDC-cDC_9\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	FLT3 VRK2 LRRK2 MRPL3	2.04e-04	193	67	4	89c63dd5d97fbd92ea308405b7e8e630dda5158d
ToppCell	3'-Broncho-tracheal_SMG-Epithelial-Epithelial_transtional-secretory-SMG_tracheobronchial_serous_cell\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ALDH1L2 SLC16A14 GNAS PHGDH	2.04e-04	193	67	4	3d1710a6060d3a70994a206334ccb16cd63e5f20
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	GRIP1 TRPM3 PLEKHA5 ALDH1L1	2.04e-04	193	67	4	82e8a4c40299ffcdfd5a0da711bb9de6fb8a2eaa
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	GRIP1 TRPM3 PLEKHA5 ALDH1L1	2.04e-04	193	67	4	3866667dd221612589ae50f5c52f73a183a49ce6
ToppCell	BAL-Severe-Myeloid-cDC-cDC-cDC_9\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	FLT3 VRK2 LRRK2 MRPL3	2.04e-04	193	67	4	7842f29c16fe3a289ed3861fa570430142d2363f
ToppCell	PBMC-Control-Myeloid-cDC-cDC-cDC_4\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	GRIP1 SLC41A2 FLT3 ATP5MF	2.08e-04	194	67	4	6af2971d83f5ad6aed16d0ceb8bfc52f3947bc10
ToppCell	3'-Broncho-tracheal_SMG-Epithelial\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ALDH1L2 SLC16A14 GNAS PHGDH	2.08e-04	194	67	4	f1d057c4bf57e75ad5a821e5f3de335dbff69062
ToppCell	3'-Broncho-tracheal_SMG\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ALDH1L2 SLC16A14 GNAS PHGDH	2.08e-04	194	67	4	42558822d7e260e7d8cf2539f1f7426e5774edfb
ToppCell	CF-Myeloid-cDC\|Myeloid / Disease state, Lineage and Cell class	SLC41A2 SLC7A1 FLT3 PLEKHA5	2.08e-04	194	67	4	3feb8a0ba3368673c53e9cbd4980e73d18697718
ToppCell	10x_3'_v2v3-Neoplastic-Differentiated-like-MES-like-MES-like_hypoxia/MHC-E\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	TRPM3 GNAS CNN3 NOVA1	2.08e-04	194	67	4	08fad7591c20568de797cf8e206de2d0b1d78aab
ToppCell	3'-Broncho-tracheal_SMG-Epithelial-Epithelial_transtional-secretory\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ALDH1L2 SLC16A14 GNAS PHGDH	2.08e-04	194	67	4	0d97dee07846416c77a861994912a9207f29ceb3
ToppCell	PBMC-Control-Myeloid-cDC-cDC-cDC_4\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	GRIP1 SLC41A2 FLT3 ATP5MF	2.08e-04	194	67	4	5c60670ec24470225fabaa6071fdb4ef6e579840
ToppCell	Megakaryocytic-erythropoietic-Erythro-cells-Erythrocyte\|Megakaryocytic-erythropoietic / Lineage, cell class and subclass	NPL UBB SLC22A4 RAD23A	2.08e-04	194	67	4	f0ababe8daa57f6827a3e2e72c884d9e8b2687a3
ToppCell	control-Myeloid-mDC\|Myeloid / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	GRIP1 SLC41A2 FLT3 MRPL3	2.08e-04	194	67	4	9bd075df18970d4577230cd421122f7163245213
ToppCell	IPF-Multiplet-Multiplet\|IPF / Disease state, Lineage and Cell class	GNA14 CFAP221 PLEKHA5 CNN3	2.12e-04	195	67	4	fce0c29574bb7aab181b9c00feb42681e285d1f2
ToppCell	10x5'-Liver-Lymphocytic_T_CD4/8-lo-Tgd_CRTAM\|Liver / Manually curated celltypes from each tissue	UBC ADRB1 GNAS DDX24	2.12e-04	195	67	4	972b09697b7b66fb8a27dfc0c0b05a844121f055
ToppCell	10x5'-Liver-Lymphocytic_T_CD4/8-lo\|Liver / Manually curated celltypes from each tissue	UBC ADRB1 GNAS DDX24	2.12e-04	195	67	4	c29c4ae95a756e3ced0f0747bbfe343590e5b8ab
ToppCell	mild-Myeloid-mDC\|Myeloid / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	GRIP1 SLC41A2 FLT3 MRPL3	2.12e-04	195	67	4	c24d286e6c7020ecbc1f460db7685a9a881fc22a
ToppCell	IPF-Multiplet\|IPF / Disease state, Lineage and Cell class	GNA14 CFAP221 PLEKHA5 CNN3	2.12e-04	195	67	4	eacc0449ae6f3ad8002268cd061467684c6fb9a7
ToppCell	droplet-Kidney-nan-3m-Epithelial\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	C11orf54 ATP5MF ALDH1L1 NDUFA5	2.16e-04	196	67	4	9f39cb3de886283da34ee7511a92d94930a6c851
ToppCell	10x_3'_v2v3-Neoplastic-Stem-like-OPC-like-OPC-like-F\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	UBB GNAS CNN3 NOVA1	2.16e-04	196	67	4	455a2a1c98da413c8e9617b964b6ed141ed3a3be
ToppCell	10x_3'_v2v3-Neoplastic-Differentiated-like-MES-like-MES-like_hypoxia_independent-G\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	SLC6A17 ATP5MF ALDH1L1 CNN3	2.16e-04	196	67	4	379132e944be2b9dcdf1a787293a48313956902c
ToppCell	droplet-Kidney-nan-3m\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	UBC ATP5MF ALDH1L1 NDUFA5	2.16e-04	196	67	4	b880c9665d42c76ea1971d4e49d7ecf72fcfafb6
ToppCell	Smart-start-Cell-Wel_seq-Neoplastic\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	UBB ATP5MF CNN3 NOVA1	2.16e-04	196	67	4	ede2468e02951959fa66ef1986b2e81e690a939d
ToppCell	Megakaryocytic-erythropoietic-Erythro-cells\|Megakaryocytic-erythropoietic / Lineage, cell class and subclass	NPL UBB SLC22A4 RAD23A	2.16e-04	196	67	4	092caba6726d1acd409a8be335100764d0724e64
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	GRIP1 SLC7A1 CFAP221 LRRK2	2.20e-04	197	67	4	7e93a97b5ac5ae2f77a4b3141082a1463fed00dd
ToppCell	343B-Epithelial_cells-Epithelial-B_(AT2)\|343B / Donor, Lineage, Cell class and subclass (all cells)	SLC7A1 SQLE LRRK2 PHGDH	2.20e-04	197	67	4	f3ca63c7902d7530a29a85eb54f69b303031d150
ToppCell	cellseq2-Epithelial-Epithelial_Glandular-Serous\|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	ALDH1L2 ALDH1L1 GNAS PHGDH	2.20e-04	197	67	4	d3539607d5477f5dfd85f1fa99b74677c0fa8937
ToppCell	Parenchymal-10x3prime_v2-Stromal-Fibroblastic-Fibro_immune_recruiting\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	MRO SLC16A14 SLC4A5 NOVA1	2.20e-04	197	67	4	31c8d6e565bbdc37843ce871fe91845b0cc18a9f
ToppCell	BAL-Mild-cDC_10\|Mild / Compartment, Disease Groups and Clusters	SLC41A2 FLT3 NMRK1 PLEKHA5	2.20e-04	197	67	4	c0550d41dd5619b369b590f3d6a61154dd7b2cab
ToppCell	COVID-19_Mild-cDC\|COVID-19_Mild / Disease condition and Cell class	GRIP1 SLC41A2 FLT3 MRPL3	2.20e-04	197	67	4	09045845891de79164124afb6c632e2838906006
ToppCell	cellseq2-Epithelial-Epithelial_Glandular-Serous-Serous\|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	ALDH1L2 ALDH1L1 GNAS PHGDH	2.20e-04	197	67	4	40bd7c314ff5254d87737822078e7b9eaf23edf3
ToppCell	facs-Heart-RV-3m\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	UBC TM9SF2 ATP5MF MTREX	2.20e-04	197	67	4	a2d9d3098e5103290b434919dbbc40d7e79fcae0
ToppCell	COVID-19_Mild-cDC-\|COVID-19_Mild / Disease condition and Cell class	GRIP1 SLC41A2 FLT3 MRPL3	2.20e-04	197	67	4	61d6dd023b2ba2bc76f17c06f7c30434ed865171
ToppCell	343B-Epithelial_cells-Epithelial-B_(AT2)-\|343B / Donor, Lineage, Cell class and subclass (all cells)	SLC7A1 SQLE LRRK2 PHGDH	2.20e-04	197	67	4	f98720cab066579fdac3ba24fb6fe4c5759dae4e
ToppCell	Epithelial_cells-Epithelial_cells\|World / Immune cells in Kidney/Urine in Lupus Nephritis	TRPM3 C11orf54 ALDH1L1 CNN3	2.25e-04	198	67	4	52e9d41a1726bc1140df6baec9f17a534448ac8b
Disease	daytime rest measurement	VRK2 HTR1A TRPM3 LRRK2 EFR3B	5.24e-04	295	66	5	EFO_0007828
Disease	renal system measurement, blood urea nitrogen measurement	BCAS3 GNAS	1.11e-03	22	66	2	EFO_0004741, EFO_0004742
Disease	insulin sensitivity measurement	ALDH1L1 PHGDH	1.21e-03	23	66	2	EFO_0004471
Disease	amyotrophic lateral sclerosis (is_marker_for)	LRRK2 MTREX	1.92e-03	29	66	2	DOID:332 (is_marker_for)
Disease	D dimer measurement	ABCA4 GCNT1	2.06e-03	30	66	2	EFO_0004507

Protein segments in the cluster

Peptide	Gene	Start	Entry
VKQMGDILSQVKGTG	UNC13A	1316	Q9UPW8
GTFTRDLTLMGKGKV	ALS2CL	531	Q60I27
KALKTLGIIMGVFTL	ADRB1	321	P08588
QTMGLGKTFSIGKIA	AVIL	351	O75366
LGVNGAGKTTTFKML	ABCA4	1971	P78363
VNGAGKTTIFKMLTG	ABCA12	2291	Q86UK0
KLGFTGSTPIGKQIM	ALDH1L2	666	Q3SY69
LKSGLTMVGKVVTQL	BCAS3	276	Q9H6U6
TMKLFTQIFGVGVKT	POLM	236	Q9NP87
FVVVMVTKTKAGQGT	RAD23A	71	P54725
KQGDTILVSGMKTGS	NUP210	201	Q8TEM1
MAFQKAVKGTILVGG	GPD2	1	P43304
SMFVKIKTLGIGAFG	LATS2	666	Q9NRM7
TKIRMSGIKGLQGVV	EFR3B	161	Q9Y2G0
MVVKIGDFGISKILS	NEK8	141	Q86SG6
KLMIVGNTGSGKTTL	LRRK2	1336	Q5S007
MKTLTVVLGKIQGKG	MRO	111	Q9BYG7
LGGSEGKLTVVAQKM	GCN1	346	Q92616
GKLTVVAQKMSVLSG	GCN1	351	Q92616
GTVGTGKSTLVRKMV	NLRX1	166	Q86UT6
GISKTGVSIQVAVKM	FLT3	631	P36888
KLEMVVKSTGILGGQ	PIKFYVE	2046	Q9Y2I7
INVKKGSISGITMVL	ATP5MF	56	P56134
LQVVKIMAFAGTGKT	FBH1	456	Q8NFZ0
PVTQQGLTGMKTGTK	IFT74	71	Q96LB3
NIKVIFSTLLGMKGT	CENPL	116	Q8N0S6
LTGGGMTVAFKDIKL	SQLE	416	Q14534
LGAGESGKSTIVKQM	GNAS	46	P63092
RKTVKTLGIIMGTFI	HTR1A	341	P08908
SGIKKNRILIGGFSM	LYPLAL1	111	Q5VWZ2
IKTAILVGGMSTQKQ	DDX24	416	Q9GZR7
MAASLVGKKIVFVTG	ITPA	1	Q9BY32
VVNGKLTNTGTVKML	GCNT1	261	Q02742
LMKKEGTTLGLTVSG	GRIP1	56	Q9Y3R0
SIGLVMLGKFGITSA	SLC22A4	426	Q9H015
IIGKGGATVKAVMEQ	NOVA1	186	P51513
GIIPANGKMTVTIKF	CFAP221	211	Q4G0U5
VTAKTIGKGFQGVMK	MRPL3	206	P09001
MKTFIIGISGVTNSG	NMRK1	1	Q9NWW6
LGTGESGKSTFIKQM	GNA14	41	O95837
VVKLGFGVSQTKAIM	NPL	256	Q9BXD5
GMLQTGVTVGSKALK	RTN4IP1	316	Q8WWV3
TGTGFGTFLMTVLLK	SLC16A14	166	Q7RTX9
IMVGVIVGSKKTGIN	SLC41A2	296	Q96JW4
QELTTVKMSKFGGGI	WDR17	796	Q8IZU2
FGEVTMTRITLKGKI	HERC2P3	941	Q9BVR0
MAGVLKKTTGLVGLA	NDUFA5	1	Q16718
IGFTGSTEVGKHIMK	ALDH1L1	646	O75891
KLKAGQSVIGLQMGT	CNN3	156	Q15417
IGMGGTFIIQKGKVK	C11orf54	201	Q9H0W9
LLGVGTSKEKGMITV	UBA6	481	A0AVT1
IKVSLSMKVVNQGTG	ZCCHC17	81	Q9NP64
GGTKGPSNVFKIVKM	MTREX	366	P42285
KGMGSTFIVQGVTLG	SLC25A46	161	Q96AG3
LGFIMVSGFVKGSVK	SLC7A1	201	P30825
QVFGKGLIKAAMTTG	TRPM3	201	Q9HCF6
AISLGKQRTGKIMGI	ZNF75CP	241	Q92670
KALGGIIMKISITQI	SLCO1B3	41	Q9NPD5
IQMGTGGSEFKIQKK	SLC4A5	971	Q9BY07
KVMLVGESGVGKSTL	REM2	116	Q8IYK8
GMQIFVKTLTGKTIT	UBB	76	P0CG47
GGMQIFVKTLTGKTI	UBB	151	P0CG47
KGMLLSVFLGSGTQI	TM9SF2	361	Q99805
SIVGMAVVKGIQSSG	SLC6A17	236	Q9H1V8
VQFVDMVKGKSLTGV	PHGDH	301	O43175
GMQIFVKTLTGKTIT	UBC	76	P0CG48
GGMQIFVKTLTGKTI	UBC	151	P0CG48
RGGMQIFVKTLTGKT	UBC	226	P0CG48
LRGGMQIFVKTLTGK	UBC	301	P0CG48
GMQIFVKTLTGKTIT	UBC	456	P0CG48
GGMQIFVKTLTGKTI	UBC	531	P0CG48
RGGMQIFVKTLTGKT	UBC	606	P0CG48
KQQRGTTEIGMIGSK	PLEKHA5	776	Q9HAU0
GTFKKSTVLQLGIRM	VRK2	136	Q86Y07
VKAVMGIFSLVTGKS	NADSYN1	451	Q6IA69