Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionprotein serine/threonine kinase activity

SMG1 SLK NEK10 CASK HIPK3 MLKL NRBP2 MTOR MASTL MAP3K11 EIF2AK1 STKLD1 MAP3K2 AURKB

4.89e-0544617814GO:0004674
GeneOntologyMolecularFunctionamino acid sensor activity

SAR1A SAR1B

7.90e-0521782GO:0140785
GeneOntologyMolecularFunctionhigh voltage-gated calcium channel activity

CACNA1B CACNA1D CACNA1F

2.36e-04141783GO:0008331
GeneOntologyMolecularFunctionATP-dependent chromatin remodeler activity

CHD3 CHD5 SMARCA4 CHD6

3.20e-04371784GO:0140658
GeneOntologyMolecularFunctionprotein kinase activity

SMG1 SLK NEK10 INSR CASK HIPK3 MLKL NRBP2 MTOR MASTL MAP3K11 EIF2AK1 STKLD1 MAP3K2 AURKB

3.24e-0460017815GO:0004672
GeneOntologyMolecularFunctionprotein serine kinase activity

SMG1 SLK NEK10 CASK HIPK3 MTOR MASTL MAP3K11 EIF2AK1 MAP3K2 AURKB

4.29e-0436317811GO:0106310
GeneOntologyMolecularFunctionkinase activity

SMG1 SLK NEK10 INSR CASK HIPK3 MLKL NRBP2 MTOR DGUOK NME5 MASTL MAP3K11 EIF2AK1 STKLD1 MAP3K2 AURKB

4.98e-0476417817GO:0016301
GeneOntologyCellularComponentCul2-RING ubiquitin ligase complex

ZYG11A PRAMEF1 PRAMEF2 PRAMEF13 PRAMEF14

4.99e-05471795GO:0031462
GeneOntologyCellularComponentSWI/SNF superfamily-type complex

MYBBP1A CHD3 BAZ2A CHD5 SMARCA4 SMARCD1

1.78e-04961796GO:0070603
DomainARM-type_fold

KPNA4 ZYG11A SMG1 MYBBP1A NEK10 USP9X IFT172 MROH2A RTTN VEPH1 CUL9 ZNFX1 HEATR1 HUWE1 USP9Y RIF1 URB1 MTOR UTP20 STKLD1 HECTD1 GCN1

1.28e-1233917722IPR016024
DomainARM-like

KPNA4 ZYG11A SMG1 NEK10 USP9X MROH2A RTTN CUL9 HEATR1 HUWE1 USP9Y RIF1 MTOR UTP20 STKLD1 HECTD1 GCN1

8.41e-1027017717IPR011989
DomainL_dom-like

ZYG11A LRRC10B INSR NLRP1 NYX PRAMEF1 LRRC43 PRAMEF2 PRAMEF13 LRIT3 LRRC55 LRRN3 NLRP9 LRRC7 GP5

5.68e-0732817715IPR032675
Domain-

KPNA4 ZYG11A NEK10 USP9X RTTN CUL9 HEATR1 RIF1 MTOR UTP20 HECTD1 GCN1

1.42e-06222177121.25.10.10
Domain-

ZYG11A LRRC10B NLRP1 NYX PRAMEF1 LRRC43 PRAMEF2 PRAMEF13 LRIT3 LRRC55 LRRN3 NLRP9 LRRC7 GP5

2.39e-06321177143.80.10.10
DomainHECT

HUWE1 NEDD4 UBR5 HERC1 HECTD1

4.92e-06271775PF00632
DomainHECTc

HUWE1 NEDD4 UBR5 HERC1 HECTD1

4.92e-06271775SM00119
DomainHECT_dom

HUWE1 NEDD4 UBR5 HERC1 HECTD1

4.92e-06271775IPR000569
DomainHECT

HUWE1 NEDD4 UBR5 HERC1 HECTD1

4.92e-06271775PS50237
DomainCa_chan_IQ

CACNA1B CACNA1D CACNA1F

2.85e-0571773SM01062
DomainCa_chan_IQ

CACNA1B CACNA1D CACNA1F

2.85e-0571773PF08763
DomainVDCC_a1su_IQ

CACNA1B CACNA1D CACNA1F

2.85e-0571773IPR014873
DomainGPHH

CACNA1B CACNA1D CACNA1F

2.85e-0571773PF16905
DomainGPHH_dom

CACNA1B CACNA1D CACNA1F

2.85e-0571773IPR031649
DomainHEAT_REPEAT

SMG1 MROH2A HEATR1 MTOR UTP20 GCN1

5.28e-05701776PS50077
DomainSAR1

SAR1A SAR1B

8.93e-0521772PS51422
DomainSmall_GTPase_SAR1

SAR1A SAR1B

8.93e-0521772IPR006687
DomainVDCCAlpha1

CACNA1B CACNA1D CACNA1F

9.56e-05101773IPR002077
DomainKinase-like_dom

SMG1 SLK NEK10 INSR CASK HIPK3 MLKL NRBP2 MTOR MASTL MAP3K11 EIF2AK1 STKLD1 MAP3K2 AURKB

2.09e-0454217715IPR011009
DomainSNF2_N

CHD3 CHD5 SMARCA4 CHD6

2.28e-04321774IPR000330
DomainSNF2_N

CHD3 CHD5 SMARCA4 CHD6

2.28e-04321774PF00176
DomainLRR_8

LRRC10B NYX LRRC43 LRIT3 LRRC55 LRRN3 LRRC7 GP5

2.30e-041711778PF13855
Domain-

ABCB7 LONP2 WRNIP1 HS3ST5 NLRP1 ZNFX1 CHD3 SLFN14 SAR1A CASK EHD2 NLRP9 DNAH12 DGUOK CHD5 SAR1B SMARCA4 CHD6

2.66e-04746177183.40.50.300
DomainCHD_N

CHD3 CHD5

2.66e-0431772IPR012958
DomainCHD_C2

CHD3 CHD5

2.66e-0431772IPR012957
DomainCAC1F_C

CACNA1D CACNA1F

2.66e-0431772IPR031688
DomainCHDCT2

CHD3 CHD5

2.66e-0431772PF08074
DomainCHDNT

CHD3 CHD5

2.66e-0431772PF08073
DomainDUF1086

CHD3 CHD5

2.66e-0431772IPR009462
DomainDUF1087

CHD3 CHD5

2.66e-0431772IPR009463
DomainCAC1F_C

CACNA1D CACNA1F

2.66e-0431772PF16885
DomainDUF1087

CHD3 CHD5

2.66e-0431772PF06465
DomainDUF1086

CHD3 CHD5

2.66e-0431772PF06461
DomainDUF1087

CHD3 CHD5

2.66e-0431772SM01147
DomainDUF1086

CHD3 CHD5

2.66e-0431772SM01146
DomainLeu-rich_rpt

LRRC10B NLRP1 NYX LRRC43 LRIT3 LRRC55 LRRN3 NLRP9 LRRC7 GP5

2.69e-0427117710IPR001611
DomainPkinase

SLK NEK10 CASK HIPK3 MLKL NRBP2 MASTL MAP3K11 EIF2AK1 STKLD1 MAP3K2 AURKB

2.88e-0438117712PF00069
DomainVDCC_L_a1su

CACNA1D CACNA1F

5.29e-0441772IPR005446
DomainLRR

LRRC10B NLRP1 LRRC43 LRIT3 LRRC55 LRRN3 LRRC7 GP5

6.76e-042011778PS51450
DomainPRAME_family

PRAMEF1 PRAMEF2 PRAMEF13

7.25e-04191773IPR026271
DomainProt_kinase_dom

SLK NEK10 INSR CASK HIPK3 MLKL NRBP2 MASTL MAP3K11 EIF2AK1 STKLD1 MAP3K2 AURKB

8.06e-0448917713IPR000719
DomainPROTEIN_KINASE_DOM

SLK NEK10 INSR CASK HIPK3 MLKL NRBP2 MASTL MAP3K11 EIF2AK1 STKLD1 MAP3K2 AURKB

8.68e-0449317713PS50011
DomainFATC

SMG1 MTOR

8.76e-0451772PF02260
DomainLRR_1

LRRC10B NLRP1 NYX LRIT3 LRRC55 LRRN3 LRRC7 GP5

1.18e-032191778PF00560
DomainP-loop_NTPase

ABCB7 LONP2 WRNIP1 HS3ST5 NLRP1 ZNFX1 CHD3 SLFN14 SAR1A CASK EHD2 NLRP9 DNAH12 DGUOK CHD5 SAR1B SMARCA4 CHD6

1.18e-0384817718IPR027417
DomainBRK

SMARCA4 CHD6

1.31e-0361772SM00592
DomainBRK_domain

SMARCA4 CHD6

1.31e-0361772IPR006576
DomainFAT

SMG1 MTOR

1.31e-0361772PS51189
DomainFATC

SMG1 MTOR

1.31e-0361772PS51190
DomainFATC_dom

SMG1 MTOR

1.31e-0361772IPR003152
DomainPIK_FAT

SMG1 MTOR

1.31e-0361772IPR014009
DomainBRK

SMARCA4 CHD6

1.31e-0361772PF07533
DomainFATC

SMG1 MTOR

1.31e-0361772SM01343
DomainChromo_domain

CHD3 CHD5 CHD6

1.46e-03241773IPR023780
DomainLRR_TYP

LRRC10B NYX LRIT3 LRRC55 LRRN3 LRRC7 GP5

1.51e-031771777SM00369
DomainLeu-rich_rpt_typical-subtyp

LRRC10B NYX LRIT3 LRRC55 LRRN3 LRRC7 GP5

1.51e-031771777IPR003591
DomainPept_M16_Zn_BS

PITRM1 PMPCB

1.82e-0371772IPR001431
DomainPept_M16_dom

PITRM1 PMPCB

1.82e-0371772IPR011237
DomainMetalloenz_LuxS/M16

PITRM1 PMPCB

1.82e-0371772IPR011249
DomainPeptidase_M16

PITRM1 PMPCB

1.82e-0371772PF00675
DomainPeptidase_M16_C

PITRM1 PMPCB

1.82e-0371772IPR007863
DomainPeptidase_M16_C

PITRM1 PMPCB

1.82e-0371772PF05193
DomainPept_M16_N

PITRM1 PMPCB

1.82e-0371772IPR011765
Domain-

PITRM1 PMPCB

1.82e-03717723.30.830.10
DomainINSULINASE

PITRM1 PMPCB

1.82e-0371772PS00143
DomainChromo

CHD3 CHD5 CHD6

1.85e-03261773PF00385
DomainHEAT

HEATR1 MTOR UTP20 GCN1

2.22e-03581774IPR000357
DomainCHROMO_1

CHD3 CHD5 CHD6

2.30e-03281773PS00598
DomainCHROMO_2

CHD3 CHD5 CHD6

2.30e-03281773PS50013
DomainN6_MTASE

HEMK1 MGAM2

2.41e-0381772PS00092
PathwayKEGG_MEDICUS_VARIANT_SCRAPIE_CONFORMATION_PRPSC_TO_VGCC_CA2_APOPTOTIC_PATHWAY

CACNA1B CACNA1D CACNA1F

1.34e-0561253M47762
Pubmed

Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.

MYBBP1A USP9X CUL9 HEATR1 HUWE1 EDC4 ANKHD1 SERPINH1 NUP205 RIF1 URB1 UBR5 BAZ2A MTOR SUPT5H SYNE2 SMARCA4 UTP20 ZFR HECTD1 GCN1 UTRN

5.58e-126531822222586326
Pubmed

Activity-Based Probes for HECT E3 Ubiquitin Ligases.

HUWE1 NEDD4 UBR5 HECTD1

3.61e-095182428425671
Pubmed

LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.

MYBBP1A TBRG4 USP9X WRNIP1 FARSB HEATR1 HUWE1 EDC4 SERPINH1 NUP205 URB1 SCAP UBR5 MTOR UTP20 SEC63 QARS1 CHPF ESPL1 HECTD1 GCN1 AURKB

5.42e-099421822231073040
Pubmed

Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.

MYBBP1A SLK RPL35A TBRG4 PITRM1 PMPCB USP9X FARSB HEATR1 HUWE1 EDC4 ANKHD1 SERPINH1 SAR1A NUP205 UBE4A RIF1 URB1 MTOR SUPT5H SMARCA4 UTP20 ZFR SEC63 QARS1 GCN1 MGAM2

7.61e-0914251822730948266
Pubmed

Functional proteomics mapping of a human signaling pathway.

SMG1 SASH1 CHD3 HUWE1 CASK NEDD4 HIPK3 DCP1B UBR5 SUPT5H CHD6 HERC1 QARS1 CHPF GGA1 UTRN TP53BP2

1.69e-085911821715231748
Pubmed

Identifying biological pathways that underlie primordial short stature using network analysis.

MYBBP1A USP9X INSR CHD3 HEATR1 HUWE1 EDC4 SERPINH1 SAR1A NUP205 RIF1 URB1 UBR5 SUPT5H SYNE2 SMARCA4 UTP20 ZFR QARS1 GCN1 UTRN AURKB

2.40e-0810241822224711643
Pubmed

Human transcription factor protein interaction networks.

SMG1 MYBBP1A SLK RPL35A ACACB PITRM1 USP9X MRPL13 CUL9 CHD3 EDC4 ANKHD1 SIRT1 NUP205 RIF1 DCP1B SAMD11 CHD5 SYNE2 SMARCA4 SMARCD1 ZFR CHD6 HERC1 QARS1 FOXI1

3.35e-0814291822635140242
Pubmed

Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.

MYBBP1A SLK USP9X ANKS1B FARSB GRIA3 ZNFX1 HUWE1 EDC4 TRIM3 CASK NEDD4 FRY UBR5 MTOR SYNE2 SMARCA4 ZFR LRRC7 DIXDC1 TP53BP2

3.98e-089631822128671696
Pubmed

VCP phosphorylation-dependent interaction partners prevent apoptosis in Helicobacter pylori-infected gastric epithelial cells.

WRNIP1 ARHGAP17 HEATR1 HUWE1 ANKHD1 NUP205 RIF1 UBR5 MTOR ZFR ESPL1 GGA1

4.51e-082881821223383273
Pubmed

A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.

RPL35A PITRM1 PMPCB IFT172 WRNIP1 FARSB HEATR1 HUWE1 ANKHD1 SIRT1 NUP205 CASK UBR5 MTOR SUPT5H TMEM131L SEC63 ESPL1 HECTD1 GCN1 UTRN

4.83e-089741822128675297
Pubmed

HAPSTR1 localizes HUWE1 to the nucleus to limit stress signaling pathways.

KPNA4 MYBBP1A USP9X WRNIP1 FARSB HEATR1 HUWE1 ANKHD1 SIRT1 NUP205 URB1 UBR5 SEC63 HECTD1 GCN1 AURKB

6.48e-085711821637167062
Pubmed

Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.

SMG1 MYBBP1A USP9X WRNIP1 HUWE1 SERPINH1 NUP205 UBR5 SUPT5H SMARCA4 SMARCD1 QARS1 ESPL1 HECTD1

9.57e-084401821434244565
Pubmed

Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.

ABCB7 WRNIP1 FARSB CUL9 SMPD4 HEATR1 HUWE1 ANKHD1 TRIM3 NUP205 UBE4A RIF1 UBR5 SMARCA4 UTP20 ZFR QARS1 FOXD4 FOXI1

1.43e-078571821925609649
Pubmed

System-Wide Modulation of HECT E3 Ligases with Selective Ubiquitin Variant Probes.

HUWE1 NEDD4 UBR5 HERC1 HECTD1

2.23e-0726182526949039
Pubmed

Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics.

CACNA1B MYBBP1A USP9X IFT172 WRNIP1 FARSB DMXL1 BHMT CASK FRY TUBGCP3 KANK4 ZFR CHD6

2.42e-074751821431040226
Pubmed

Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.

MYBBP1A ABCB7 FARSB DDI2 CHD3 HEATR1 HUWE1 PRAMEF1 PRAMEF2 ANKHD1 PRAMEF13 URB1 SCAP GLG1 PRAMEF14 MASTL TMEM131L HERC1 SEC63 ESPL1 UTRN

2.84e-0710841822111544199
Pubmed

The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation.

MYBBP1A USP9X IFT172 WRNIP1 HEATR1 HUWE1 EDC4 SERPINH1 NUP205 RIF1 MTOR TUBGCP3 SMARCA4 QARS1 HECTD1 GCN1

2.89e-076381821633239621
Pubmed

Differences in gene expression between mouse and human for dynamically regulated genes in early embryo.

PRAMEF1 PRAMEF2 PRAMEF13 NLRP9 PRAMEF14

3.31e-0728182525089626
Pubmed

E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.

CACNA1F TBC1D30 TBC1D2 DDI2 HUWE1 NUP205 TMEM260 FRY URB1 THBS4 CHRD UTP20 LRRC7 CHD6 SLC26A11 UTRN GP5

3.82e-077361821729676528
Pubmed

The functional interactome landscape of the human histone deacetylase family.

KPNA4 USP9X WRNIP1 CHD3 HEATR1 HUWE1 RIF1 UBR5 SYNE2 ZFR GCN1

4.10e-072891821123752268
Pubmed

Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.

KPNA4 ABCB7 PITRM1 PMPCB THTPA HEATR1 TRIM3 URB1 UBR5 COMMD8 MTOR TUBGCP3 UTP20 ZFR CHPF HECTD1 GCN1

5.33e-077541821733060197
Pubmed

The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.

MYBBP1A FARSB CHD3 HEATR1 NUP205 NSUN5 RIF1 URB1 MB21D2 SMARCA4 UTP20 ZFR QARS1 ESPL1 HECTD1 GCN1 AURKB

5.84e-077591821735915203
Pubmed

Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.

MYBBP1A RPL35A PMPCB FARSB HEATR1 HUWE1 ANKHD1 SERPINH1 NUP205 NSUN5 RIF1 URB1 UBR5 BAZ2A TUBGCP3 SMARCA4 UTP20 ZFR PRR14L QARS1 GCN1 UTRN TP53BP2

7.25e-0713531822329467282
Pubmed

The splicing regulator Rbfox2 is required for both cerebellar development and mature motor function.

CACNA1B CACNA1D HUWE1 CASK CHD5

7.83e-0733182522357600
Pubmed

KAP1 facilitates reinstatement of heterochromatin after DNA replication.

KPNA4 MYBBP1A PMPCB FARSB HEATR1 HUWE1 ANKHD1 NUP205 NSUN5 UBR5 MTOR SMARCA4 UTP20 ZFR GCN1 AURKB

1.05e-067041821629955894
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

KPNA4 USP9X IFT172 ANKS1B CUL9 ZNFX1 HUWE1 USP9Y CASK UBE4A FRY SUPT5H SMARCA4 NECAB3 MAP3K11 CHD6 EIF2AK1 QARS1 CHPF HECTD1 UTRN ZNF292

1.15e-0612851822235914814
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

RTTN CUL9 ARHGAP17 HUWE1 EDC4 ANKHD1 PCNX2 URB1 C2CD3 SCAP MTOR CHD5 MAP3K11 HERC1 CHPF ESPL1 HECTD1 GGA1 GCN1 AGTRAP

1.58e-0611051822035748872
Pubmed

An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.

WRNIP1 ARHGAP17 SMPD4 HUWE1 SAR1A DENND4C SCAP DCP1B MASTL SMARCA4 TMEM131L CHD6 PRR14L SEC63 ESPL1 HECTD1

1.77e-067331821634672954
Pubmed

An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.

KPNA4 MYBBP1A PITRM1 LONP2 ALKBH2 IFT172 HEATR1 DENND4C NUP205 RIF1 MB21D2 DCP1B MTOR SUPT5H EIF2AK1 QARS1 CHPF GGA1 GCN1 TP53BP2 MAP3K2 AURKB

1.80e-0613211822227173435
Pubmed

AMPK, a Regulator of Metabolism and Autophagy, Is Activated by Lysosomal Damage via a Novel Galectin-Directed Ubiquitin Signal Transduction System.

MYBBP1A RPL35A ABCB7 PITRM1 PMPCB USP9X INSR FARSB HEATR1 SERPINH1 NUP205 CASK URB1

1.85e-064841821331995728
Pubmed

The promoter of the oocyte-specific gene, Oog1, functions in both male and female meiotic germ cells in transgenic mice.

PRAMEF1 PRAMEF2 PRAMEF13 PRAMEF14

2.10e-0618182423894331
Pubmed

Oogenesin is a novel mouse protein expressed in oocytes and early cleavage-stage embryos.

PRAMEF1 PRAMEF2 PRAMEF13 PRAMEF14

2.10e-0618182412890732
Pubmed

Oocyte-specific gene Oog1 suppresses the expression of spermatogenesis-specific genes in oocytes.

PRAMEF1 PRAMEF2 PRAMEF13 PRAMEF14

2.10e-0618182429731491
Pubmed

Identification of a new expanding family of genes characterized by atypical LRR domains. Localization of a cluster preferentially expressed in oocyte.

PRAMEF1 PRAMEF2 PRAMEF13 PRAMEF14

2.10e-0618182414675769
Pubmed

SARS-CoV-2 Nsp6 damages Drosophila heart and mouse cardiomyocytes through MGA/MAX complex-mediated increased glycolysis.

MYBBP1A USP9X WRNIP1 SMPD4 HEATR1 HUWE1 SAR1A RIF1 UBR5 MTOR TUBGCP3 SMARCA4 SEC63 QARS1 GCN1

2.19e-066571821536180527
Pubmed

Pramel7 mediates ground-state pluripotency through proteasomal-epigenetic combined pathways.

PRAMEF1 PRAMEF2 PRAMEF13 PRAMEF14

2.64e-0619182428604677
Pubmed

Virus-Host Interactome and Proteomic Survey Reveal Potential Virulence Factors Influencing SARS-CoV-2 Pathogenesis.

CHD3 EDC4 ANKHD1 SERPINH1 URB1 UTP20 ZFR HERC1 HECTD1 GCN1

2.89e-062851821032838362
Pubmed

Preferentially Expressed Antigen in Melanoma (PRAME) and the PRAME Family of Leucine-Rich Repeat Proteins.

PRAMEF1 PRAMEF2 PRAMEF13 PRAMEF14

3.29e-0620182426694250
Pubmed

Oog1, an oocyte-specific protein, interacts with Ras and Ras-signaling proteins during early embryogenesis.

PRAMEF1 PRAMEF2 PRAMEF13 PRAMEF14

3.29e-0620182416580637
Pubmed

Pramel7 mediates LIF/STAT3-dependent self-renewal in embryonic stem cells.

PRAMEF1 PRAMEF2 PRAMEF13 PRAMEF14

3.29e-0620182421425410
Pubmed

Defining the membrane proteome of NK cells.

MYBBP1A RPL35A LONP2 USP9X WRNIP1 FARSB HEATR1 HUWE1 EDC4 NUP205 DCP1B UBR5 MTOR GLG1 CHD5 TUBGCP3 SMARCA4 MAP3K11 GGA1 GCN1

3.64e-0611681822019946888
Pubmed

LRF maintains genome integrity by regulating the non-homologous end joining pathway of DNA repair.

MYBBP1A RPL35A HUWE1 UBR5 SMARCA4 GCN1

3.83e-0679182626446488
Pubmed

Sertoli cell-only phenotype and scRNA-seq define PRAMEF12 as a factor essential for spermatogenesis in mice.

PRAMEF1 PRAMEF2 PRAMEF13 PRAMEF14

4.93e-0622182431729367
Pubmed

Oogenesis specific genes (Nobox, Oct4, Bmp15, Gdf9, Oogenesin1 and Oogenesin2) are differentially expressed during natural and gonadotropin-induced mouse follicular development.

PRAMEF1 PRAMEF2 PRAMEF13 PRAMEF14

5.94e-0623182419480014
Pubmed

Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism.

KPNA4 ABCB7 PITRM1 PMPCB USP9X HEATR1 EDC4 SAR1A SIRT1 NUP205 UBE4A SCAP UBR5 TMEM131L SMARCD1 ALG8 EIF2AK1 SEC63 HECTD1 GCN1 ZNF292

6.88e-0613271822132694731
Pubmed

Evolutionary insights into T-type Ca2+ channel structure, function, and ion selectivity from the Trichoplax adhaerens homologue.

CACNA1B CACNA1D CACNA1F

7.74e-068182328330839
Pubmed

Incomplete reactivation of Oct4-related genes in mouse embryos cloned from somatic nuclei.

PRAMEF1 PRAMEF2 PRAMEF13 PRAMEF14

8.42e-0625182412620990
Pubmed

MAGE-B4, a binding partner of PRAMEF12, is dispensable for spermatogenesis and male fertility in mice.

PRAMEF1 PRAMEF2 PRAMEF13 PRAMEF14

8.42e-0625182437451217
Pubmed

N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.

MYBBP1A SLK ACACB FARSB CHD3 HEATR1 EDC4 ANKHD1 RIF1 BAZ2A MASTL SMARCA4 ZFR PRR14L GCN1 UTRN TP53BP2

9.30e-069341821733916271
Pubmed

Expression profiling in transgenic FVB/N embryonic stem cells overexpressing STAT3.

PRAMEF1 PRAMEF2 PRAMEF13 PRAMEF14

9.91e-0626182418500982
Pubmed

C9orf72 protein quality control by UBR5-mediated heterotypic ubiquitin chains.

MYBBP1A RPL35A ABCB7 USP9X WRNIP1 MRPL13 FARSB SMPD4 HUWE1 SERPINH1 NUP205 NSUN5 RIF1 URB1 UBR5 SMARCA4 QARS1 HECTD1 GCN1 AURKB

1.07e-0512571822037317656
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

SLK IFT172 CUL9 ADCY2 SNX13 NEDD4 UBR5 BAZ2A SEL1L3 LRRC7 CHD6

1.10e-054071821112693553
Pubmed

Activity-based E3 ligase profiling uncovers an E3 ligase with esterification activity.

CUL9 HUWE1 NEDD4 UBR5 HERC1 HECTD1

1.12e-0595182629643511
Pubmed

HSF1 phosphorylation establishes an active chromatin state via the TRRAP-TIP60 complex and promotes tumorigenesis.

KPNA4 CYP27A1 SMPD4 HEATR1 EDC4 NUP205 THBS4 SCAP UBR5 SYNE2 SMARCA4 ZFR CHD6 EIF2AK1 SEC63

1.14e-057541821535906200
Pubmed

Interplay between protein acetylation and ubiquitination controls MCL1 protein stability.

USP9X SERPINH1 SIRT1

1.65e-0510182334758305
Pubmed

A model for obesity and gigantism due to disruption of the Ankrd26 gene.

INSR MC4R MTOR

1.65e-0510182318162531
Pubmed

Systematic identification of factors for provirus silencing in embryonic stem cells.

USP9X HUWE1 SIRT1 RIF1 UBR5 SMARCA4 SMARCD1

1.71e-05153182726365490
Pubmed

Thirteen Ovary-Enriched Genes Are Individually Not Essential for Female Fertility in Mice.

PRAMEF1 PRAMEF2 PRAMEF13 PRAMEF14

1.79e-0530182438786026
Pubmed

MYC multimers shield stalled replication forks from RNA polymerase.

MYBBP1A RPL35A WRNIP1 HEATR1 HUWE1 SERPINH1 NUP205 NSUN5 RIF1 URB1 SUPT5H SMARCA4 UTP20 ZFR SEC63 QARS1 AURKB

1.93e-059891821736424410
Pubmed

Ubiquitin ligase TRIM71 suppresses ovarian tumorigenesis by degrading mutant p53.

USP9X CUL9 HUWE1

2.26e-0511182331570706
Pubmed

A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.

SMG1 TBRG4 ABCB7 FARSB SMPD4 HEATR1 HUWE1 EDC4 SERPINH1 NUP205 EHD2 UBE4A URB1 UBR5 COMMD8 MTOR SYNE2 ZFR SEC63 QARS1 GCN1

2.33e-0514401822130833792
Pubmed

LSM14B is essential for oocyte meiotic maturation by regulating maternal mRNA storage and clearance.

PRAMEF1 PRAMEF2 PRAMEF13 PRAMEF14

2.33e-0532182437889087
Pubmed

Transcriptome analysis of mouse stem cells and early embryos.

MYBBP1A FARSB PRAMEF1 PRAMEF2 PRAMEF13 SAR1A UBE4A PRAMEF14 CHD6 UTRN

2.37e-053631821014691545
Pubmed

Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions.

ACACB USP9X DENND4C UBR5 SMARCD1 QARS1 HECTD1 UTRN TP53BP2 MAP3K2 AURKB

2.56e-054461821124255178
Pubmed

The E3 ubiquitin ligases, HUWE1 and NEDD4-1, are involved in the post-translational regulation of the ABCG1 and ABCG4 lipid transporters.

WRNIP1 HUWE1 NEDD4 HECTD1

2.64e-0533182426296893
Pubmed

Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.

SMG1 URB1 SCAP UBR5 CHD5 SYNE2 CHD6 GCN1

2.64e-05225182812168954
Pubmed

Cytosolic carnitine acetyltransferase as a source of cytosolic acetyl-CoA: a possible mechanism for regulation of cardiac energy metabolism.

ACACB CRAT

2.72e-052182229438065
Pubmed

Angiotensin II type 1 receptor-associated protein deficiency attenuates sirtuin1 expression in an immortalised human renal proximal tubule cell line.

SIRT1 AGTRAP

2.72e-052182231719572
Pubmed

Voltage-Gated Cav1 Channels in Disorders of Vision and Hearing.

CACNA1D CACNA1F

2.72e-052182225966695
Pubmed

Exercise activates Sirt1-mediated Drp1 acetylation and inhibits hepatocyte apoptosis to improve nonalcoholic fatty liver disease.

SIRT1 UTRN

2.72e-052182236882837
Pubmed

Functional overlap between the mammalian Sar1a and Sar1b paralogs in vivo.

SAR1A SAR1B

2.72e-052182238687799
Pubmed

Ubiquitin-specific protease activity of USP9Y, a male infertility gene on the Y chromosome.

USP9X USP9Y

2.72e-052182212895410
Pubmed

Nedd4 E3 ubiquitin ligase promotes cell proliferation and autophagy.

NEDD4 MTOR

2.72e-052182225809873
Pubmed

Associations between INSR and MTOR polymorphisms in type 2 diabetes mellitus and diabetic nephropathy in a Northeast Chinese Han population.

INSR MTOR

2.72e-052182225867326
Pubmed

Silencing of mammalian Sar1 isoforms reveals COPII-independent protein sorting and transport.

SAR1A SAR1B

2.72e-052182223433038
Pubmed

The endoplasmic reticulum coat protein II transport machinery coordinates cellular lipid secretion and cholesterol biosynthesis.

SAR1A SAR1B

2.72e-052182224338480
Pubmed

Modulation of membrane rigidity by the human vesicle trafficking proteins Sar1A and Sar1B.

SAR1A SAR1B

2.72e-052182222974979
Pubmed

C-terminal modulator controls Ca2+-dependent gating of Ca(v)1.4 L-type Ca2+ channels.

CACNA1D CACNA1F

2.72e-052182216921373
Pubmed

Transcriptional and epigenetic effects of Vitis vinifera L. leaf extract on UV-stressed human dermal fibroblasts.

SERPINH1 SIRT1

2.72e-052182232666439
Pubmed

The nob2 mouse, a null mutation in Cacna1f: anatomical and functional abnormalities in the outer retina and their consequences on ganglion cell visual responses.

CACNA1F NYX

2.72e-052182216597347
Pubmed

The Drosophila developmental gene fat facets has a human homologue in Xp11.4 which escapes X-inactivation and has related sequences on Yq11.2.

USP9X USP9Y

2.72e-05218228922996
Pubmed

Identification of Myb-binding protein 1A (MYBBP1A) as a novel substrate for aurora B kinase.

MYBBP1A AURKB

2.72e-052182220177074
Pubmed

The downregulation of SASH1 expression promotes breast cancer occurrence and invasion accompanied by the activation of PI3K-Akt-mTOR signaling pathway.

SASH1 MTOR

2.72e-052182239300116
Pubmed

Effect of caloric restriction on the SIRT1/mTOR signaling pathways in senile mice.

SIRT1 MTOR

2.72e-052182226135885
Pubmed

mTOR signaling promotes foam cell formation and inhibits foam cell egress through suppressing the SIRT1 signaling pathway.

SIRT1 MTOR

2.72e-052182228765952
Pubmed

Defining MAP3 kinases required for MDA-MB-231 cell tumor growth and metastasis.

MAP3K11 MAP3K2

2.72e-052182222139075
Pubmed

Deubiquitinase USP9X loss sensitizes renal cancer cells to mTOR inhibition.

USP9X MTOR

2.72e-052182237260183
Pubmed

Mutations in the CACNA1F and NYX genes in British CSNBX families.

CACNA1F NYX

2.72e-052182212552565
Pubmed

Alisertib induces cell cycle arrest and autophagy and suppresses epithelial-to-mesenchymal transition involving PI3K/Akt/mTOR and sirtuin 1-mediated signaling pathways in human pancreatic cancer cells.

SIRT1 MTOR

2.72e-052182225632225
Pubmed

Usp9y (ubiquitin-specific protease 9 gene on the Y) is associated with a functional promoter and encodes an intact open reading frame homologous to Usp9x that is under selective constraint.

USP9X USP9Y

2.72e-052182212925892
Pubmed

CHD6 is a DNA-dependent ATPase and localizes at nuclear sites of mRNA synthesis.

CHD3 CHD6

2.72e-052182217027977
Pubmed

Sirt1 ameliorates systemic sclerosis by targeting the mTOR pathway.

SIRT1 MTOR

2.72e-052182228532580
Pubmed

X-Linked Congenital Stationary Night Blindness

CACNA1F NYX

2.72e-052182220301423
Pubmed

Recruitment of separase to mitotic chromosomes is regulated by Aurora B.

ESPL1 AURKB

2.72e-052182219342897
Pubmed

Molecular analysis of SAR1-related cDNAs from a mouse pituitary cell line.

SAR1A SAR1B

2.72e-05218228262187
Pubmed

SAR1B senses leucine levels to regulate mTORC1 signalling.

SAR1A SAR1B

2.72e-052182234290409
Pubmed

Novel mutations in CACNA1F and NYX in Dutch families with X-linked congenital stationary night blindness.

CACNA1F NYX

2.72e-052182215761389
Pubmed

Retinoic acid receptors are required for skeletal growth, matrix homeostasis and growth plate function in postnatal mouse.

PRAMEF1 PRAMEF2 PRAMEF13 PRAMEF14

3.35e-0535182419389355
Pubmed

Defining the Protein-Protein Interaction Network of the Human Protein Tyrosine Phosphatase Family.

RPL35A PMPCB LONP2 USP9X MRPL13 THTPA DDI2 HEATR1 SIRT1 NUP205 NSUN5 UBR5 SUPT5H SEC63 UTRN AURKB

3.44e-059311821627432908
Pubmed

TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.

SMG1 TBRG4 ACACB USP9X FARSB ZNFX1 SAR1A ADCY2 DNAH12 SYNE2 LPO SMARCD1 CHD6

3.48e-056381821331182584
InteractionSIRT7 interactions

MYBBP1A USP9X CUL9 HEATR1 HUWE1 EDC4 ANKHD1 SERPINH1 SIRT1 NUP205 RIF1 URB1 UBR5 BAZ2A MTOR SUPT5H SYNE2 SMARCA4 UTP20 ZFR HECTD1 GCN1 UTRN

1.19e-0774417423int:SIRT7
InteractionZBTB7A interactions

MYBBP1A RPL35A CHD3 HUWE1 SIRT1 UBR5 SMARCA4 UTP20 GCN1

2.08e-061311749int:ZBTB7A
InteractionFOXB1 interactions

SMPD4 HEATR1 HUWE1 NUP205 UBE4A RIF1 UBR5 ZFR QARS1

2.67e-061351749int:FOXB1
InteractionDUSP2 interactions

THTPA ANKHD1 NUP205 UBR5 TMEM131L ESPL1 GCN1

6.44e-06811747int:DUSP2
InteractionCCDC8 interactions

MYBBP1A USP9X MROH2A CUL9 CHD3 HEATR1 HUWE1 SERPINH1 NUP205 DNAH12 UBR5 UTP20 ZFR QARS1 HECTD1 GCN1 UTRN AURKB

1.58e-0565617418int:CCDC8
InteractionGYPA interactions

SMG1 TBRG4 TMEM31 SAR1A UBE4A MTOR TUBGCP3 UTP20 ZNF292

2.09e-051741749int:GYPA
InteractionLMBR1L interactions

MYBBP1A TBRG4 USP9X WRNIP1 FARSB HEATR1 HUWE1 EDC4 SERPINH1 NUP205 URB1 SCAP UBR5 MTOR UTP20 SEC63 QARS1 CHPF ESPL1 HECTD1 GCN1 AURKB

2.30e-0594617422int:LMBR1L
InteractionSQSTM1 interactions

KPNA4 SMG1 SLK TBRG4 IFT172 INSR MRPL13 GRIA3 HUWE1 ANKHD1 SERPINH1 NEDD4 MB21D2 SCAP COMMD8 MTOR GLG1 SAR1B SMARCD1 ZFR HECTD1 GGA1 UTRN TP53BP2 MAP3K2 AURKB

2.99e-05125717426int:SQSTM1
InteractionOBSL1 interactions

CACNA1B MYBBP1A RTTN CUL9 GCHFR HEATR1 HUWE1 EDC4 SERPINH1 NUP205 RIF1 URB1 SUPT5H SYNE2 SMARCA4 UTP20 ZFR HECTD1 GCN1 UTRN MGAM2

3.52e-0590217421int:OBSL1
InteractionEED interactions

KPNA4 MYBBP1A RPL35A ACACB USP9X FARSB SMPD4 CHD3 HEATR1 HUWE1 SERPINH1 SIRT1 DMXL1 NUP205 NEDD4 NSUN5 RIF1 URB1 MB21D2 BAZ2A SUPT5H SAR1B TUBGCP3 SMARCA4 SMARCD1 UTP20 ZFR HECTD1

4.57e-05144517428int:EED
InteractionAFF2 interactions

KPNA4 SAR1A SAR1B

5.11e-0591743int:AFF2
InteractionHDAC11 interactions

WRNIP1 HEATR1 HUWE1 RIF1 UBR5 SYNE2 ZFR GCN1

5.88e-051541748int:HDAC11
Cytoband1p36.21

DDI2 PRAMEF1 PRAMEF2 PRAMEF13 PRAMEF14

5.41e-066318251p36.21
CytobandXp11.4

USP9X NYX CASK

3.35e-04341823Xp11.4
GeneFamilyPRAME family

PRAMEF1 PRAMEF2 PRAMEF13 PRAMEF14

1.55e-05241164686
GeneFamilyCalcium voltage-gated channel subunits

CACNA1B CACNA1D CACNA1F

6.01e-04261163253
CoexpressionGSE27241_WT_VS_RORGT_KO_TH17_POLARIZED_CD4_TCELL_TREATED_WITH_DIGOXIN_UP

SMG1 USP9X NUP205 RIF1 BAZ2A SMARCD1 PRR14L HERC1 ESPL1 UTRN

5.33e-0718018110M8239
ToppCell10x5'-GI_small-bowel-Lymphocytic_T_CD4-T_CD4/CD8|GI_small-bowel / Manually curated celltypes from each tissue

SMG1 USP9X HUWE1 SYNE2 TMEM131L HERC1 UTRN TP53BP2 MAP3K2

8.50e-081881829ab9b725d6e0cdab8e9ddda6dee09e14730e9a578
ToppCellfacs-Tongue-nan-3m-Epithelial-nan|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SMG1 MYBBP1A RPL35A USP9X HUWE1 NEDD4 EHD2 GLG1

1.68e-0619918288d50e1ee58710d896c0204937331d9f4dcd38de0
ToppCellnormal_Pleural_Fluid-Myeloid_cells-CD163+CD14+_DCs|Myeloid_cells / Location, Cell class and cell subclass

NLRP1 ALS2CL ADCY2 PNMA5 URB1 SYNE2 CHPF

6.27e-061691827bea8aba1f3cc3d0e8d448c1c45f5354d26ebf850
ToppCellnormal_Pleural_Fluid-Myeloid_cells-CD163+CD14+_DCs|normal_Pleural_Fluid / Location, Cell class and cell subclass

DDI2 NLRP1 ALS2CL ADCY2 HIPK3 PNMA5 URB1

8.17e-0617618277a74217b7fa1032b918f00a3972dff5fab74671a
ToppCell10x5'-Liver-Lymphocytic_T_CD4-T_CD4/CD8|Liver / Manually curated celltypes from each tissue

SMG1 HUWE1 UBR5 SYNE2 TMEM131L HERC1 MAP3K2

9.81e-061811827f2315414e714ac86211546a935660c4be6e85f1b
ToppCellCOVID-19_Mild-Lymphoid_T/NK-CD4+_T_activated|COVID-19_Mild / Disease group, lineage and cell class

CHD3 ALS2CL PCNX2 LRRN3 SYNE2 TMEM131L GCN1

1.05e-0518318277717fce227b4e02ed41baad8ae7dd2e22bd7c13e
ToppCellPosterior_cortex-Neuronal-Excitatory-eN1(Slc17a7)-eN1_1-Bcl6-Excitatory_Neuron.Slc17a7.Bcl6-Cbln1_(Layer_5a,_entorhinal_cortex_,_Cbln1+)|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

STAB2 KLHL41 BHMT SLC6A5 XKRX

1.32e-057418250be24b07a2503a16ece1489e765200be4c7253cc
ToppCellCD8+_Memory_T_cell-CV-7|CD8+_Memory_T_cell / cell class, Virus stimulation and cluster

HEATR1 HUWE1 UBE4A URB1 GLG1 TMEM131L ZNF292

1.39e-0519118279454f642c3621370fa23640b631301346b300950
ToppCellTCGA-Prostate-Primary_Tumor-Prostate_Adenocarcinoma-Acinar_Adenocarcinoma-6|TCGA-Prostate / Sample_Type by Project: Shred V9

USP9X DDI2 HUWE1 DENND4C BAZ2A HECTD1 UTRN

1.49e-051931827abd71b2cf667ef2b1c4d88acd0c1dd19a12ff659
ToppCellfacs-Brain_Non-Myeloid-Cortex-3m-Neuronal|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PCSK1 CACNA1B PCNX2 LRRC55 CHD5 NECAB3 LRRC7

1.59e-051951827ffbab350e67d9c4b66c0ab84550daec8b8139a27
ToppCelldroplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNA1D USP9X HUWE1 RIF1 ZFR HERC1 PCSK9

1.59e-0519518273e519cffa6144a62b06124642a14c9ff39b76554
ToppCelldroplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNA1D USP9X HUWE1 RIF1 ZFR HERC1 PCSK9

1.59e-0519518277796ea9247f4c63762f0de8490fed08b9717fa23
ToppCellMid-temporal_gyrus_(MTG)-Neuronal|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CACNA1B CACNA1D ANKS1B GRIA3 FRY CHD5 LRRC7

1.64e-051961827676c56b44ac29f7baecb62f49bb8597cc74c0a88
ToppCellfacs-Trachea-3m|Trachea / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SASH1 USP9X SERPINH1 SAR1A NEDD4 EHD2 GLG1

1.70e-051971827e77016d64b1cac9825fec7cfe5071f1567401187
ToppCellmild-low-quality_cells|mild / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

SMG1 NEK10 RTTN USP9Y SYNE2 UTRN ZNF292

1.70e-051971827e4331969bd911d1ebb5453f40a7057297b5389b4
ToppCellfacs-Trachea-nan-3m|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SASH1 USP9X SERPINH1 SAR1A NEDD4 EHD2 GLG1

1.70e-0519718270353d925ee4b7aefc2c51b5fab873f465cdf9ebc
ToppCellSomatosensory_Cortex_(S1)-Neuronal|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CACNA1B CACNA1D ANKS1B ADCY2 FRY CHD5 LRRC7

1.75e-051981827c01091ef18e096d792ea2a7a715764a5b215355f
ToppCellprimary_auditory_cortex_(A1C)-Neuronal|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CACNA1B CACNA1D ANKS1B GRIA3 FRY CHD5 LRRC7

1.75e-0519818276d18b45eda4014759e6dd282d78ffd28df8a6044
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CACNA1B CACNA1D ANKS1B FRY CHD5 LRRC7 HERC1

1.75e-0519818270ff30edfd3c133a42e8cb96e1631a1143215f808
ToppCellmild-low-quality_cells|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

SMG1 RTTN USP9Y SYNE2 HERC1 UTRN ZNF292

1.81e-051991827f0b0097df0026496470a80d8cc9375ffd8389b00
ToppCellNeuronal|World / cells hierarchy compared to all cells using T-Statistic

CACNA1B CACNA1D ANKS1B FRY CHD5 LRRC7 HERC1

1.87e-05200182748d801219bc771d6c7e151dc88ca4c179988de85
ToppCellBrain_organoid-organoid_Tanaka_cellReport-2m-Neuronal-Intermediate|2m / Sample Type, Dataset, Time_group, and Cell type.

CHD3 LRRC55 FRY SYNE2 ZFR HECTD1 ZNF292

1.87e-0520018272a635694844ddabcd98462c5636a6f41a3f08a46
ToppCell367C-Lymphocytic-CD4_T-cell-Treg_cell_2|367C / Donor, Lineage, Cell class and subclass (all cells)

KLHL10 ANKS1B CUL9 DCP1B SYNE2 XKRX

4.60e-051571826f1c6c313836352271033d23efd31b0f0a8a09e02
ToppCellnormal_Pleural_Fluid-T/NK_cells-CD4+_Th|normal_Pleural_Fluid / Location, Cell class and cell subclass

ANKS1B MRPL13 FRY CYP4F22 SLC26A11 AGTRAP

4.93e-051591826ebd840ac2b07e62086ee7b5bb01c21804a0fdc7b
ToppCellPosterior_cortex-Neuronal-Excitatory-eN1(Slc17a7)-eN1_1-Calb1-Excitatory_Neuron.Sc17a7.Calb1-Otof_(Layer_2/3)|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

NEK10 LRRC43 PNMA5 FOXI1

6.50e-05531824a41f66edf468f824494a922c3addf429a9125b7f
ToppCelldroplet-Marrow-nan-18m-Myeloid-basophil|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NXPE4 CYP27A1 NLRP1 SIRT1 TRIM3 MAP3K2

8.12e-05174182655cc8300489d11322724159ec7d0e1d32a702e91
ToppCellfacs-Marrow-B-cells-3m-Lymphocytic-early_pro_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MROH2A NYX ALS2CL BAZ2A SMARCA4 UTRN

8.65e-05176182629cda51a99100ddd2928cadc92da40f001d7e1f4
ToppCellfacs-Marrow-B-cells-3m-Lymphocytic-early_pro-B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MROH2A NYX ALS2CL BAZ2A SMARCA4 UTRN

8.65e-05176182601774a86d7d92f31a056b753f9844f923038003e
ToppCell356C-Lymphocytic-CD4_T-cell-Treg_cell_1|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)

TBC1D2 ANKHD1 DMXL1 MTOR SAR1B PDE7B

8.93e-05177182636b5d29caa9cffbc0284f771a4db71aa72171a89
ToppCell(5)_Epithelial_cells-(5)_Glands_mucous|(5)_Epithelial_cells / Oesophagus cell shreds on cell class (v1) and cell subclass (v1)

NXPE4 VEPH1 NME5 SEL1L3 CHRD BPIFB2

9.79e-051801826a4118adaf4b09e2ca01b662ed60e7bbf32a24d58
ToppCellPBMC-Mild-Lymphocyte-T/NK-CD4+_T-CD4+_T_activated|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)

CHD3 PCNX2 LRRN3 SYNE2 TMEM131L GCN1

1.04e-0418218261aea96ee211f7b9caef7fd385233f51be6021a73
ToppCellPBMC-Mild-Lymphocyte-T/NK-CD4+_T-CD4+_T_activated-|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

CHD3 PCNX2 LRRN3 SYNE2 TMEM131L GCN1

1.04e-041821826b427e43ee523a3ea9eca3207f3d82042f10f022a
ToppCellPBMC-Mild-Lymphocyte-T/NK-CD4+_T-CD4+_T_activated-|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

CHD3 PCNX2 LRRN3 SYNE2 TMEM131L GCN1

1.04e-041821826c0f63cfc67d61c0877b7acb2946dfb35aae8a8f5
ToppCellPBMC-Mild-Lymphocyte-T/NK-CD4+_T-CD4+_T_activated|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

CHD3 PCNX2 LRRN3 SYNE2 TMEM131L GCN1

1.04e-0418218264cb182ef39be2044a6ad7266f332d4177591e550
ToppCellCalu_3-infected|Calu_3 / Cell line, Condition and Strain

USP9X ZNFX1 RIF1 SYNE2 UTRN ZNF292

1.07e-0418318268f7f5000645f24f20a8d7700c4df1f8953a1780b
ToppCellwk_20-22-Mesenchymal-Chondrocyte-intermediate_chondrocyte|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

SLK HS3ST5 CASK UBE4A URB1 SAMD11

1.07e-0418318261464b5c4425e8776c4aeb4d2b560481d4bf13931
ToppCell343B-Lymphocytic-CD4_T-cell-Treg_cell_4|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)

IFT172 CUL9 MLKL ADGRF3 CHPF XKRX

1.07e-0418318263cbe0175d05fd39bc430de1ef471ff2c5b56460e
ToppCellSubstantia_nigra-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Slc17a6.Tcf4_(Supramammillary_Nucleus_(SuM))-|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

KLHL10 KLHL41 NYX SERTM2

1.13e-0461182446cdf693c7f2df4fc43df7837b152871af67bef0
ToppCellSubstantia_nigra-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Slc17a6.Tcf4_(Supramammillary_Nucleus_(SuM))--|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

KLHL10 KLHL41 NYX SERTM2

1.13e-04611824c73fa489427a6e11badbdfc0324008137806ac7d
ToppCellSubstantia_nigra-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Slc17a6.Tcf4_(Supramammillary_Nucleus_(SuM))|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

KLHL10 KLHL41 NYX SERTM2

1.13e-04611824c2c633f49f6ad8581c33794c909f40aa59f0b5c5
ToppCell3'-GW_trimst-1-SmallIntestine-Epithelial-neuro-epithelial-Progenitor_(NEUROG3+)|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PCSK1 LRRC10B CYP27A1 TBC1D2 BHMT RNF39

1.14e-0418518262088e82e0febdcf05618d3db913d00e2e87812f4
ToppCellCV-Moderate-7|Moderate / Virus stimulation, Condition and Cluster

HEATR1 HUWE1 URB1 TMEM131L SEC63 ZNF292

1.14e-041851826a6c9203ce6c2892a4a369c9bcfb85720f01cbb3f
ToppCelldroplet-Spleen-nan-3m|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SMG1 RPL35A CHD3 ALS2CL DMXL1 UTRN

1.17e-04186182626f1e9930adf2fe4af0819e56f69915bd8330e4a
ToppCellCV-Moderate-7|CV / Virus stimulation, Condition and Cluster

HEATR1 HUWE1 URB1 TMEM131L SEC63 ZNF292

1.17e-0418618268571956890fc9894d766ba294a28e376b4aba428
ToppCell343B-Lymphocytic-CD4_T-cell-Treg_cell_4|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

IFT172 CUL9 MLKL DCP1B ADGRF3 XKRX

1.17e-041861826bca5215d406f1785bf3a420201d5686071fcaca5
ToppCell368C-Lymphocytic-CD4_T-cell-Treg_cell_3|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)

SLK ABCB7 SASH1 ANKS1B GLG1 GCN1

1.21e-041871826689b3cc76f1e04bd35a7d3ce19e9f08744a7835b
ToppCell368C-Lymphocytic-CD4_T-cell-Treg_cell_3|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

SLK ABCB7 SASH1 ANKS1B GLG1 GCN1

1.21e-0418718264527d6426f2c4397e47f12439a13a8c14fd2aab2
ToppCell390C-Lymphocytic-CD4_T-cell-Treg_cell_1|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

THTPA DDI2 RILP CHRNA5 NUP205 SLC26A11

1.24e-041881826b1ec7c45aedcc3d22cac898c6a3679e7f8b44c77
ToppCellrenal_papilla_nuclei-Adult_normal_reference|renal_papilla_nuclei / Celltypes from Cells and Nuclei per compartment and clinical group

ACACB ANKS1B HS3ST5 USP9Y FRY UTRN

1.39e-0419218266c106b91e46eabbe686a52a65a9c94ad9cbe9390
ToppCell10x5'-lymph-node_spleen-Lymphocytic_T_CD4-T_CD4/CD8|lymph-node_spleen / Manually curated celltypes from each tissue

SMG1 NLRP1 SYNE2 TMEM131L HERC1 MAP3K2

1.39e-04192182647646d7e4990be85072987f92bf18d52f8da752e
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_no-steroids-Epithelial-Epithelial,_Airway-ciliated_cell|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

NEK10 IFT172 LRRC10B ANKMY1 DNAH12 NME5

1.39e-04192182603acd4a26b986e34eee608747347791122f1aa52
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_no-steroids-Epithelial-Epithelial,_Airway-ciliated_cell-Epi-Ciliated|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

NEK10 IFT172 LRRC10B ANKMY1 DNAH12 NME5

1.39e-04192182631c6046589e2fbb0486fd044c5b128099d37872f
ToppCellfacs-Aorta-Heart-3m|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLK USP9X MROH2A INSR RIF1 GLG1

1.39e-0419218261ccc47792edf9ee23501c8e2165d11271636b66a
ToppCellfacs-Brain_Non-Myeloid-Cortex-3m-Neuronal-neuron|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PCSK1 CACNA1B LRRC55 CHD5 NECAB3 LRRC7

1.43e-041931826461919ab422bc9d1fcff7a3a4757c75239041d7e
ToppCellfacs-Brain_Non-Myeloid-Cortex-3m-Neuronal-nan|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PCSK1 CACNA1B LRRC55 CHD5 NECAB3 LRRC7

1.43e-0419318260dd810ad900d3e586551622b2c1de39d76fd6a7f
ToppCelldroplet-Pancreas-Endocrine-21m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PCSK1 USP9X DENND4C LRRC55 SMARCA4 CHPF

1.43e-041931826471e65f02937bc18d7c5facdacdf1df58cf0f839
ToppCellsevere-low-quality_cells|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

SMG1 USP9Y SYNE2 HERC1 UTRN ZNF292

1.43e-0419318269337bc93e3904c7fc7c93c328518bcd6453b1e8c
ToppCelldroplet-Pancreas-Endocrine-21m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PCSK1 USP9X DENND4C LRRC55 SMARCA4 CHPF

1.43e-041931826fe451b3295d77b2bd1ac25cf29310c85835a45fe
ToppCellfacs-Marrow-B-cells-18m-Lymphocytic-precursor_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRRC10B EHD2 LRRN3 SMARCA4 TMEM131L SEC63

1.47e-041941826ad1aacff97beb76f4211942676e1d5e84087d44e
ToppCellfacs-Marrow-B-cells-18m-Lymphocytic-pre_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRRC10B EHD2 LRRN3 SMARCA4 TMEM131L SEC63

1.47e-041941826fdd59b1e036b2d6d8877e1a920a0e56a91a2a882
ToppCelldroplet-Pancreas-Endocrine-21m-Epithelial|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PCSK1 HUWE1 DENND4C LRRC55 SMARCA4 CHPF

1.47e-0419418260b023de48ed8a550d169bbe954881eb04bf4f981
ToppCellsevere-low-quality_cells|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

SMG1 CHD3 SYNE2 HERC1 UTRN ZNF292

1.60e-04197182657ebd552f10d6278623b52a3d484d4b91ae1d028
ToppCellLPS_anti-TNF-Epithelial_alveolar-AT_1-Differentiating_AT2|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

CACNA1F VEPH1 SYNE2 SMARCA4 RNF39 UTRN

1.60e-0419718263d13a4f2e86422900ee2194e8a1fd1cf9750d5d3
ToppCellfacs-Tongue-nan-3m-Epithelial|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SMG1 USP9X HUWE1 NEDD4 EHD2 GLG1

1.65e-0419818262f03f8897dd7cce6d8296638e14e11ec16bcf624
ToppCellfacs-Tongue-nan-3m-Epithelial-basal_cell_of_epidermis|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SMG1 USP9X SERPINH1 NEDD4 EHD2 GLG1

1.65e-04198182622559b161e67b49fe8028bfaf861e069063599f5
ToppCellfacs-Trachea-nan-3m-Mesenchymal-fibroblast|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SERPINH1 NEDD4 EHD2 CPQ GLG1 CHPF

1.65e-0419818260dc7d59a07428a7b7e8bdc81f0e2417dd4ce3cf2
ToppCellfacs-Tongue-nan-3m|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SMG1 USP9X HUWE1 NEDD4 EHD2 GLG1

1.65e-041981826f2a4057f038ef7225a5b98a7ab068c30dff4eadd
ToppCellfacs-Trachea-nan-3m-Mesenchymal|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SASH1 SERPINH1 NEDD4 EHD2 GLG1 CHPF

1.69e-04199182667f78c070c56e44fba36542041bf7fa1c291807c
ToppCellfacs-Trachea-nan-3m-Mesenchymal-nan|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SASH1 SERPINH1 NEDD4 EHD2 GLG1 CHPF

1.69e-0419918261ae244b563f85c1ee8d22698f478c842a4d9c7f5
ToppCellLPS_IL1RA-Endothelial-Endothelial-Activated_Alv_Cap|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

SASH1 SERPINH1 NEDD4 EHD2 FRY SYNE2

1.74e-04200182679e51afb57ca38aacebd0298e5e727b55c0cfff9
ToppCellLPS_IL1RA_TNF-Endothelial-Endothelial-Alv_Cap|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

SASH1 SERPINH1 NEDD4 EHD2 FRY KANK4

1.74e-042001826b7533c571eeea0cb3678e1a57d3dc036fa8d0f49
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW12-OPC_related-Oligodendrocyte/OPC|GW12 / Sample Type, Dataset, Time_group, and Cell type.

NEDD4 EHD2 MLKL KANK4 SERTM2 HEMK1

1.74e-0420018264db894cfb80fd1f9e01133f345eefd78edd4bc43
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW12-OPC_related|GW12 / Sample Type, Dataset, Time_group, and Cell type.

NEDD4 EHD2 MLKL KANK4 SERTM2 HEMK1

1.74e-042001826d46a19274c2836ce7494790ce513764dedcadc79
ToppCellControl_saline-Endothelial-Endothelial-Alv_Cap|Control_saline / Treatment groups by lineage, cell group, cell type

SASH1 SERPINH1 NEDD4 EHD2 FRY KANK4

1.74e-042001826abf4ba5fcb54cdeada0da1a8b956a30aa47679e4
ToppCellBrain_organoid-organoid_Tanaka_cellReport-10w-Neuronal-Intermediate|10w / Sample Type, Dataset, Time_group, and Cell type.

IFT172 SMPD4 RILP LRRC43 ESPL1 MAP3K2

1.74e-042001826e5a8647c47a49c8c90c78d681193946de103d8ff
Drug0179445-0000 [211246-22-9]; Down 200; 10uM; PC3; HT_HG-U133A

ACACB LONP2 CUL9 ANKMY1 DMXL1 PCNX2 NECAB3 DIXDC1 ESPL1 UTRN AURKB

3.16e-07191177114289_DN
Diseasefatty liver disease (implicated_via_orthology)

ACACB INSR MC4R SIRT1 SEC63

1.01e-06311745DOID:9452 (implicated_via_orthology)
Diseasepalmitoyl dihydrosphingomyelin (d18:0/16:0) measurement

SYNE2 SMARCA4 PCSK9

6.93e-0671743EFO_0800400
Diseaselevel of Sphingomyelin (d38:1) in blood serum

SLC52A1 NLRP1 SYNE2 PCSK9

2.84e-05301744OBA_2045180
DiseaseX-linked congenital stationary night blindness

CACNA1F NYX

3.46e-0521742cv:CN043584
Diseasecongenital stationary night blindness (implicated_via_orthology)

CACNA1F NYX

3.46e-0521742DOID:0050534 (implicated_via_orthology)
Diseaselevel of Sphingomyelin (d40:1) in blood serum

SLC52A1 NLRP1 SMARCA4 PCSK9

3.69e-05321744OBA_2045182
DiseaseNight blindness, congenital stationary, type 1

CACNA1F NYX LRIT3

4.26e-05121743C3501847
DiseaseNight Blindness, Congenital Stationary, Type 1A

CACNA1F NYX LRIT3

4.26e-05121743C3495587
DiseaseNIGHT BLINDNESS, CONGENITAL STATIONARY, TYPE 2B (disorder)

CACNA1F NYX LRIT3

4.26e-05121743C1864877
DiseaseNIGHT BLINDNESS, CONGENITAL STATIONARY, TYPE 1B

CACNA1F NYX LRIT3

4.26e-05121743C1850362
DiseaseX-Linked Csnb

CACNA1F NYX LRIT3

4.26e-05121743C3711543
DiseaseNIGHT BLINDNESS, CONGENITAL STATIONARY, TYPE 2A

CACNA1F NYX LRIT3

4.26e-05121743C1848172
DiseaseCone-rod synaptic disorder, congenital nonprogressive

CACNA1F NYX LRIT3

5.52e-05131743C4041558
DiseaseDuchenne muscular dystrophy (implicated_via_orthology)

CACNA1D CACNA1F SLC6A5 UTRN

5.94e-05361744DOID:11723 (implicated_via_orthology)
DiseaseNight blindness, congenital stationary

CACNA1F NYX LRIT3

1.29e-04171743C0339535
DiseaseCongenital stationary night blindness

CACNA1F NYX

2.06e-0441742cv:C0339535
DiseaseTimothy syndrome (implicated_via_orthology)

CACNA1D CACNA1F

2.06e-0441742DOID:0060173 (implicated_via_orthology)
Diseasepalmitoyl sphingomyelin (d18:1/16:0) measurement

SMARCA4 PCSK9

2.06e-0441742EFO_0800300
DiseaseMalignant neoplasm of breast

KLK10 MRPL13 ALS2CL CRHR1 SIRT1 NEDD4 RIF1 NLRP9 MTOR CHD5 SYNE2 SLC6A5 SMARCD1 UTP20 LRRC7 GGA1 TP53BP2

2.20e-04107417417C0006142
Diseasepolycystic liver disease (is_implicated_in)

ALG8 SEC63

3.42e-0451742DOID:0050770 (is_implicated_in)
DiseasePolycystic liver disease

ALG8 SEC63

3.42e-0451742C0158683
DiseaseInsulin Resistance

ACACB INSR MC4R SIRT1

4.40e-04601744C0021655
DiseaseInsulin Sensitivity

ACACB INSR MC4R SIRT1

4.40e-04601744C0920563
Diseaseglycosyl ceramide (d18:1/20:0, d16:1/22:0) measurement

SYNE2 PCSK9

7.12e-0471742EFO_0800551
Diseasehereditary ataxia (implicated_via_orthology)

CACNA1B PITRM1

7.12e-0471742DOID:0050951 (implicated_via_orthology)
DiseaseLarge cell carcinoma of lung

CASK MTOR MAP3K2

8.81e-04321743C0345958
Diseasesyndromic X-linked intellectual disability (implicated_via_orthology)

HUWE1 CASK

9.46e-0481742DOID:0060309 (implicated_via_orthology)
DiseaseClinically Isolated Syndrome, CNS Demyelinating

MAT1A SIRT1

9.46e-0481742C2350037
DiseaseDemyelinating Diseases

MAT1A SIRT1

9.46e-0481742C0011303
DiseaseDemyelination

MAT1A SIRT1

9.46e-0481742C0011304
DiseasePARTINGTON X-LINKED MENTAL RETARDATION SYNDROME

GRIA3 CASK

9.46e-0481742C0796250
Diseasecomplex trait

KPNA4 IFT172 MC4R ARHGAP17 KANK4 CHD6 PCSK9

1.18e-032711747EFO_0010578
DiseaseCarcinoma, Small Cell

MTOR SMARCA4

1.21e-0391742C0262584
DiseaseIntellectual Disability

CACNA1B PITRM1 RTTN FARSB CHD3 FRY MTOR SMARCD1 ZNF292

1.41e-034471749C3714756
DiseaseCocaine Dependence

MC4R CHRNA5 CRHR1 SMARCA4 LRRC7

1.43e-031391745C0600427
Diseasefree cholesterol:total lipids ratio, intermediate density lipoprotein measurement

ACACB SNX13 SMARCA4 PCSK9

1.70e-03861744EFO_0008595, EFO_0020945
Diseaserenal cell carcinoma

SLK SASH1 INSR

1.95e-03421743EFO_0000681
DiseaseBipolar Disorder

CACNA1B CACNA1D GPR78 GRIA3 ADCY2 CRHR1 SIRT1 NEDD4 DIXDC1

2.19e-034771749C0005586
DiseaseAnxiety States, Neurotic

CHRNA5 CRHR1 DIXDC1

2.23e-03441743C0376280
DiseaseAnxiety neurosis (finding)

CHRNA5 CRHR1 DIXDC1

2.23e-03441743C1279420
DiseaseAnxiety Disorders

CHRNA5 CRHR1 DIXDC1

2.23e-03441743C0003469
Diseasecortisol measurement, response to corticosteroid, response to synacthen

ANKS1B PDE7B

2.58e-03131742EFO_0005843, EFO_0009175, GO_0031960
DiseaseSaldino-Noonan Syndrome

IFT172 C2CD3

3.00e-03141742C0036069
Diseasetriglyceride measurement, low density lipoprotein cholesterol measurement

TCEA2 ACACB SYNE2 SMARCA4 PCSK9

3.10e-031661745EFO_0004530, EFO_0004611
Diseasecholesteryl esters:total lipids ratio, intermediate density lipoprotein measurement

SNX13 SYNE2 SMARCA4 PCSK9

3.28e-031031744EFO_0008595, EFO_0020944
Diseasecholesterol to total lipids in small VLDL percentage

SMARCA4 MAP3K11 PCSK9

3.41e-03511743EFO_0022242
Diseasecongenital disorder of glycosylation type I (implicated_via_orthology)

ALG1L2 ALG8

3.45e-03151742DOID:0050570 (implicated_via_orthology)
DiseaseBody Weight

PCSK1 MC4R

3.45e-03151742C0005910
Diseaselevel of Phosphatidylcholine (16:0_16:0) in blood serum

SNX13 SMARCA4

3.45e-03151742OBA_2045067
Diseasehealth literacy measurement

SMG1 UTP20 GGA1

3.80e-03531743EFO_0010104
Diseasetriglycerides to total lipids in very large VLDL percentage

SMARCA4 MAP3K11 PCSK9

3.80e-03531743EFO_0022340
Diseaseresponse to triptolide, cytotoxicity measurement

NEK10 TP53BP2

3.93e-03161742EFO_0006952, EFO_0007662
Diseaselevel of Sterol ester (27:1/18:1) in blood serum

SMARCA4 PCSK9

3.93e-03161742OBA_2045195
DiseaseMalignant lymphoma, lymphocytic, intermediate differentiation, diffuse

UBR5 MTOR

3.93e-03161742C0334634
Diseasecholesterol to total lipids in very large VLDL percentage

SMARCA4 MAP3K11 PCSK9

4.01e-03541743EFO_0022244
Diseaselevel of Sphingomyelin (d32:1) in blood serum

SYNE2 SMARCA4

4.44e-03171742OBA_2045173
DiseaseFeeding difficulties

SMARCD1 ZNF292

4.97e-03181742C0232466
Diseaselevel of Sphingomyelin (d34:1) in blood serum

SMARCA4 PCSK9

4.97e-03181742OBA_2045175
Diseasefree cholesterol to total lipids in very large VLDL percentage

SMARCA4 MAP3K11 PCSK9

5.14e-03591743EFO_0022289
Diseasevon Willebrand factor measurement, coronary artery disease

STAB2 PMPCB SMARCA4 PCSK9

5.32e-031181744EFO_0001645, EFO_0004629
Diseasecholesterol:total lipids ratio, intermediate density lipoprotein measurement

SNX13 SYNE2 SMARCA4 PCSK9

5.81e-031211744EFO_0008595, EFO_0020943

Protein segments in the cluster

PeptideGeneStartEntry
EAARLKAHLMSQPLA

BHMT

236

Q93088
VAVVRLPLAHGSLLM

ALKBH2

211

Q6NS38
TRDLQVHGLVLPLML

ALS2CL

751

Q60I27
QLAKHRVLPLMVLLG

ADGRF3

876

Q8IZF5
VMLEPRIHKIAILGL

CPQ

121

Q9Y646
HDLLGPHMLRRLKAD

CHD5

921

Q8TDI0
EAPLDLQHRLFMKLG

ALG1L2

21

C9J202
MLKALHPRGIREKAL

BAZ2A

1451

Q9UIF9
MRLVLALAAHFKPGS

DIXDC1

116

Q155Q3
LTHDIAKLMPLLRQE

EHD2

386

Q9NZN4
GIIHRDLKPDNMLIS

MASTL

151

Q96GX5
KLHFEALMNIPVLVL

DGUOK

236

Q16854
LLDMRALLQSHPRAK

CRAT

611

P43155
MALIRTALEIKLAPA

CACNA1B

1796

Q00975
HPLQLLELMDLGKVR

DMXL1

1326

Q9Y485
IAHGMRVKFNPLALL

TP53BP2

916

Q13625
LLTDHRVPGLLLEAM

RILP

276

Q96NA2
LGKAARRLSLMLHGL

EDC4

1381

Q6P2E9
TQRLLHLLLDDMPVK

NUP205

1136

Q92621
LRALKGKHFLLDPLM

NSUN5

171

Q96P11
QIAMGVPLHRLKDIR

ACACB

606

O00763
LGRIRSLPKALIDMH

ANKS1B

716

Q7Z6G8
MKALVPLLHIALLVL

CACNA1F

231

O60840
VRDDKMPLAHLAIAV

PMPCB

286

O75439
KELKRILTQPHFMAL

CASK

426

O14936
LMELPRGLFLHAKRL

LRRC55

101

Q6ZSA7
TKAMDLHAVLAELPR

NRBP2

336

Q9NSY0
LDMSVPAVAKLRRLL

LONP2

161

Q86WA8
DGHSMPKAALLIIVL

MAGEA9

191

P43362
MDFTLLVPALKLHDR

MB21D2

116

Q8IYB1
LEHGLEIMKLPVSRN

NEDD4

241

P46934
VNMLLPGDKIGLHLR

MGAM2

751

Q2M2H8
LPKSMHKLAQLERLD

LRRC7

176

Q96NW7
VAAGERGKPLMLLLH

EPHX4

86

Q8IUS5
MDIITHILALAPRLL

HEMK1

271

Q9Y5R4
PDTHLAEILMKTLLR

HERC1

936

Q15751
MRPALKGAILSLLGH

GRIA3

141

P42263
LLEMLNLHPAVVKAS

HS3ST5

106

Q8IZT8
DLLHKVVAPAIRMSL

PCNX2

1681

A6NKB5
MSGDLLELALKLPHV

PCSK9

126

Q8NBP7
LDLLLKVPPHMLRAH

NEK10

961

Q6ZWH5
PLLKLACSNIHMIGL

OR4P4

181

Q8NGL7
MRVLLHLPALLASLI

LPO

1

P22079
IGMLRESRLLAHLPK

PDE7B

251

Q9NP56
GMLLEKPARVELHHI

NLRP1

1191

Q9C000
GVLLKMIHNALRFIP

NLRP1

1216

Q9C000
SGPLVAMILARHKAI

NME5

76

P56597
MQDLAVLHKASRPAL

MAP3K2

11

Q9Y2U5
MALAIPIAVKFLHRG

VEPH1

126

Q14D04
LDHMLRLIPESLKEG

DNAH12

116

Q6ZR08
PRHGMFVKDLILLVN

KLHL41

296

O60662
PLTIILAHKLNARMA

MAT1A

151

Q00266
PALLRMGRLHILDLD

LRRC10B

176

A6NIK2
KMLARLLKSSHPEDL

GGA1

176

Q9UJY5
GDFIRHLMDLLKPEL

TUBGCP3

571

Q96CW5
HLMDLLKPELVRPAT

TUBGCP3

576

Q96CW5
TRHLGVILPAVMLAL

GCN1

2106

Q92616
LDMPLLRTLDLHNNK

LRIT3

126

Q3SXY7
IEGHLQILLMFKTRP

INSR

56

P06213
DKIAALRMPLLSLHL

COMMD8

131

Q9NX08
LRMPLLSLHLDVKEN

COMMD8

136

Q9NX08
ALITMAILQSPHKRL

FOXD4

111

Q12950
MKALALLADLHPSVR

GPR78

211

Q96P69
LGLIHADLKPENIML

HIPK3

316

Q9H422
LTDVMLHALLIKDVP

HUWE1

581

Q7Z6Z7
LGHRVLGLIKPLEML

MLKL

31

Q8NB16
LHQVKKAMLRPALFA

MYBBP1A

121

Q9BQG0
AALPLLTKEQLHLVM

MYBBP1A

311

Q9BQG0
ALRTDLVSPKHALMV

SMPD4

491

Q9NXE4
MIRLVGKHHPDLLSD

IFT172

1016

Q9UG01
KLMVRSADLHPLSEL

DCP1B

296

Q8IZD4
ILHQRAMDVKLDPAL

GLG1

621

Q92896
DLLVVAHDLIRKMSP

FAM118A

86

Q9NWS6
NAMAPLVRKIFLHTL

CHRNA5

346

P30532
ERLLLSLLPAHIAME

ADCY2

241

Q08462
PLAKHGLTEELLSRM

HECTD1

226

Q9ULT8
DSHKLLRSIILLLMG

ESPL1

941

Q14674
HISILLPKVRLALMH

KLHL10

221

Q6JEL2
SALLLHVLLMVPDGK

C2CD3

801

Q4AC94
PELMQHLGASKRRAL

GCHFR

26

P30047
MGIVHRDLKPRNIFL

EIF2AK1

436

Q9BQI3
LMALEHKVLLTGTPL

CHD6

616

Q8TD26
LHDLLGPHMLRRLKA

CHD3

956

Q12873
AHMPLLKAVLKETLR

CYP27A1

381

Q02318
EKQLMHLGLLTPVER

DENND4C

286

Q5VZ89
RLISHGADILKPVML

ANKMY1

756

Q9P2S6
MGGHPQLRLVKALLL

CRHR1

1

P34998
FLMARLHIKRIAVLP

MC4R

216

P32245
THLPGALLDKMVLLE

GP5

111

P40197
LKSPTHMEIAGLLRA

KANK4

971

Q5T7N3
RHLEPIMVLSGLELA

CUL9

1576

Q8IWT3
LAPVRILAMNHLKKI

HEATR1

491

Q9H583
LLSRLLAHMPLDKAE

FRY

2066

Q5TBA9
LIAMAIHGAPDKRLT

FOXI1

131

Q12951
MLLANPHELSLLKER

DDI2

141

Q5TDH0
KFLGSLRARLMLLHP

SCAP

246

Q12770
KAMVPLLHIALLVLF

CACNA1D

266

Q01668
MLPITDRLLHLLGLE

CYP4F22

1

Q6NT55
RLFAMLAHPNIIALK

MAP3K11

166

Q16584
LSSPEFLDHIRKVML

NGB

56

Q9NPG2
AMVLIRLSHLLSEKP

TBRG4

101

Q969Z0
MQHSLRDLVPLKAFL

LRRC43

471

Q8N309
LLEGLHMLLTQKDRP

PRAMEF13

81

Q5VWM6
LLHLNKEMPLATGRD

PRR14L

671

Q5THK1
MLVLLLHAVVLGLPS

NYX

6

Q9GZU5
PSNLMLDRLSGKILH

MTOR

2341

P42345
PVRALAMEALSHLSK

MROH2A

871

A6NES4
LLAMLLRKAGAITLP

RTTN

1746

Q86VV8
MQVLHLLGPKLEADL

QARS1

171

P47897
LLAIMPDELKHIIGA

SNX13

881

Q9Y5W8
KTAHRADLFPILMRI

UTP20

1001

O75691
PVDIMDLALSAHIKI

USP9X

521

Q93008
TNLLGLHPKIEMARA

UTRN

846

P46939
NLPAKAIGHRIRVML

RPL35A

91

P18077
MLLRLKHVISPINSD

SERTM2

56

A0A1B0GWG4
KHPSLFQALLEMDLL

SEL1L3

506

Q68CR1
ALLKAMELIETHRPS

SLFN14

831

P0C7P3
HELNPMRVLLKIAKS

SLK

236

Q9H2G2
RMKFSEIPQRLHALL

SMARCD1

351

Q96GM5
LHLHLQPLEMKRVGV

TMEM131L

676

A2VDJ0
FLAIIHALRPDLIDM

SYNE2

216

Q8WXH0
KMHLAPGRFIERLKL

SLC6A5

736

Q9Y345
MKDMPLRIHVLLGLA

LRRN3

1

Q9H3W5
KAIQHLLLRSPDTMV

NXPE4

456

Q6UWF7
LLEGLHMLLTQKDRP

PRAMEF14

81

Q5SWL7
ALAVLEKTLPEMRAH

ARHGAP17

226

Q68EM7
RLKLLMQPLSSIHVR

RIF1

316

Q5UIP0
PIRSHLMELGLTAAK

SMG1

1416

Q96Q15
TDPDHASLKILARLM

PITRM1

876

Q5JRX3
LMEHKRINGPFLIIV

SMARCA4

796

P51532
VEMPLAHKLSSLIIL

SERPINH1

256

P50454
HLMIGTDPRTILKDL

SIRT1

191

Q96EB6
LLHMLKDDRLGQHVP

SAR1A

41

Q9NR31
PLLTEEHLLTNMGLK

SAMD11

576

Q96NU1
LLEGLHMLLTQKDRP

PRAMEF1

81

O95521
LTMHELKVLPRDLQL

SUPT5H

506

O00267
EPLKALLEGLHMLLT

PRAMEF2

76

O60811
LLEGLHMLLTQKDRP

PRAMEF2

81

O60811
KDLSVLMDRLPSLLH

URB1

1336

O60287
FPLNKLTELLRHDMA

FARSB

391

Q9NSD9
IHGLLDRIMQLLDVP

FARSB

511

Q9NSD9
VAKLAGLHDAILRMP

ABCB7

581

O75027
EKPLLDHLNALLAMG

BPIFB2

411

Q8N4F0
HEKAILLAILPMSLL

ALG8

381

Q9BVK2
LAAMNGHVPAVKLLL

ANKHD1

1196

Q8IWZ3
RLMDLLSKKHPLDTL

CHPF

596

Q8IZ52
PELLRHLAKGMASLM

CHRD

616

Q9H2X0
HMGDLRKKVAFLLLP

C11orf42

126

Q8N5U0
VPMGAQDLISKLLRH

AURKB

296

Q96GD4
MELPAVNLKVILLGH

AGTRAP

1

Q6RW13
MLRHPKLIKLLGFSE

NLRP9

286

Q7RTR0
HLLARVAMTPALRGK

PNMA5

291

Q96PV4
NGIDLIKHRKMAPLD

TAS2R1

31

Q9NYW7
MEKIGLPIILHLFAL

TMEM31

116

Q5JXX7
MLAPRGAAVLLLHLV

THBS4

1

P35443
SRKLPIKGAEHMSLL

SHF

401

Q7M4L6
MAAPTLGRLVLTHLL

SLC52A1

1

Q9NWF4
LLLVLKLMRDHVPPV

SLC26A11

211

Q86WA9
LLMLLHSAARPETKV

SLC26A11

461

Q86WA9
LEELMPLLKLRHAHI

STKLD1

71

Q8NE28
FEGPILLDMRIKHLI

ZNF292

186

O60281
ALEKIHRLSSMLGVP

THTPA

171

Q9BU02
LLDRINLKEHMPTFL

SASH1

641

O94885
ARVLLLSHLARMKIP

SEC63

301

Q9UGP8
GKMRHLEDALLPETL

SERPINA13P

261

Q6UXR4
GLLHILDRAMDKLEP

STAB2

496

Q8WWQ8
RDLLRMKLPELSQHL

TBC1D30

391

Q9Y2I9
LPMSRAFRGKHLSLI

USP9Y

876

O00507
LAAMASIRLQGLHKP

MRPL13

31

Q9BYD1
KSLLHQLLPEDFLML

ZNFX1

1671

Q9P2E3
LHLRNAPTRLMKDLG

WRNIP1

616

Q96S55
LAFRQIHKVLGMDPL

ZFR

1021

Q96KR1
LRELKAMPITLHLLQ

TCEA2

31

Q15560
GSIERMKNPHLRAKL

UBE4A

666

Q14139
LRAKLAEVLEAVMPH

UBE4A

676

Q14139
DLAKDKPLSLFMHLI

XKRX

91

Q6PP77
LLHMLKDDRLGQHVP

SAR1B

41

Q9Y6B6
ILKLVAIGMRNHPLD

ZYG11A

381

Q6WRX3
LLSEKLPRLMAHLGQ

TBC1D2

766

Q9BYX2
LHAMRKGLLDVLPKN

UBR5

2651

O95071
LLTSMPHDAIILLRG

TMEM260

426

Q9NX78
LGSAPEVLLVRKHMR

TRIM3

261

O75382
KMLHRLTADLTLDPG

RNF39

221

Q9H2S5
RQKHGEAPVFLMILL

TRAV30

56

A0A087WSZ9
MELPVLLLHQLSKFD

PP2D1

221

A8MPX8
DANLVPMIIHLLDKG

KPNA4

366

O00629
ASGARALAKLLPLLM

KLK10

11

O43240
HDLMLLKLARPVVLG

KLK10

136

O43240
TALRELLEKTMHPSL

LEUTX

21

A8MZ59
RMTAALPKLDLHVIP

PCSK1

136

P29120
DLAKGPDLHILMAQR

NECAB3

286

Q96P71