Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	homophilic cell adhesion via plasma membrane adhesion molecules	FAT4 PCDHAC2 PCDHA12 PCDHA7 PCDHA5 PCDHA4 DCHS1 CDH15 PLXNB3	2.46e-07	187	97	9	GO:0007156
GeneOntologyBiologicalProcess	multi-pass transmembrane protein insertion into ER membrane	NOMO1 NOMO2 NOMO3	8.30e-06	9	97	3	GO:0160063
GeneOntologyBiologicalProcess	cell-cell adhesion via plasma-membrane adhesion molecules	FAT4 PCDHAC2 PCDHA12 PCDHA7 PCDHA5 PCDHA4 DCHS1 CDH15 PLXNB3	1.69e-05	313	97	9	GO:0098742
GeneOntologyCellularComponent	multi-pass translocon complex	NOMO1 NOMO2 NOMO3	8.74e-06	9	100	3	GO:0160064
GeneOntologyCellularComponent	ER membrane insertion complex	NOMO1 NOMO2 NOMO3	3.72e-05	14	100	3	GO:0072379
GeneOntologyCellularComponent	histone methyltransferase complex	NSD1 CHD8 KMT2C KMT2D	4.62e-04	75	100	4	GO:0035097
Domain	Cadherin_CS	FAT4 PCDHAC2 PCDHA12 PCDHA7 PCDHA5 PCDHA4 DCHS1 CDH15	1.06e-07	109	98	8	IPR020894
Domain	CADHERIN_1	FAT4 PCDHAC2 PCDHA12 PCDHA7 PCDHA5 PCDHA4 DCHS1 CDH15	1.40e-07	113	98	8	PS00232
Domain	Cadherin	FAT4 PCDHAC2 PCDHA12 PCDHA7 PCDHA5 PCDHA4 DCHS1 CDH15	1.40e-07	113	98	8	PF00028
Domain	CADHERIN_2	FAT4 PCDHAC2 PCDHA12 PCDHA7 PCDHA5 PCDHA4 DCHS1 CDH15	1.50e-07	114	98	8	PS50268
Domain	-	FAT4 PCDHAC2 PCDHA12 PCDHA7 PCDHA5 PCDHA4 DCHS1 CDH15	1.50e-07	114	98	8	2.60.40.60
Domain	CA	FAT4 PCDHAC2 PCDHA12 PCDHA7 PCDHA5 PCDHA4 DCHS1 CDH15	1.60e-07	115	98	8	SM00112
Domain	Cadherin-like	FAT4 PCDHAC2 PCDHA12 PCDHA7 PCDHA5 PCDHA4 DCHS1 CDH15	1.71e-07	116	98	8	IPR015919
Domain	Cadherin	FAT4 PCDHAC2 PCDHA12 PCDHA7 PCDHA5 PCDHA4 DCHS1 CDH15	1.96e-07	118	98	8	IPR002126
Domain	DUF2012	NOMO1 NOMO2 NOMO3	5.58e-07	4	98	3	PF09430
Domain	DUF2012	NOMO1 NOMO2 NOMO3	5.58e-07	4	98	3	IPR019008
Domain	Cadherin_tail	PCDHAC2 PCDHA12 PCDHA7 PCDHA5 PCDHA4	1.37e-06	37	98	5	PF15974
Domain	Cadherin_CBD	PCDHAC2 PCDHA12 PCDHA7 PCDHA5 PCDHA4	1.37e-06	37	98	5	IPR031904
Domain	Carb-bd-like_fold	NOMO1 NOMO2 NOMO3	7.70e-06	8	98	3	IPR013784
Domain	Cadherin_2	PCDHAC2 PCDHA12 PCDHA7 PCDHA5 PCDHA4	2.31e-05	65	98	5	PF08266
Domain	Cadherin_N	PCDHAC2 PCDHA12 PCDHA7 PCDHA5 PCDHA4	2.31e-05	65	98	5	IPR013164
Domain	CarboxyPept_regulatory_dom	NOMO1 NOMO2 NOMO3	3.86e-05	13	98	3	IPR014766
Domain	-	NOMO1 NOMO2 NOMO3	3.86e-05	13	98	3	2.60.40.1120
Domain	Post-SET_dom	NSD1 KMT2C KMT2D	7.47e-05	16	98	3	IPR003616
Domain	PostSET	NSD1 KMT2C KMT2D	7.47e-05	16	98	3	SM00508
Domain	POST_SET	NSD1 KMT2C KMT2D	7.47e-05	16	98	3	PS50868
Domain	CarboxyPept-like_regulatory	NOMO1 NOMO2 NOMO3	9.03e-05	17	98	3	IPR008969
Domain	FYrich_C	KMT2C KMT2D	2.70e-04	5	98	2	IPR003889
Domain	FYrich_N	KMT2C KMT2D	2.70e-04	5	98	2	IPR003888
Domain	FYRC	KMT2C KMT2D	2.70e-04	5	98	2	SM00542
Domain	FYRN	KMT2C KMT2D	2.70e-04	5	98	2	SM00541
Domain	FYRN	KMT2C KMT2D	2.70e-04	5	98	2	PF05964
Domain	FYRC	KMT2C KMT2D	2.70e-04	5	98	2	PF05965
Domain	FYRC	KMT2C KMT2D	2.70e-04	5	98	2	PS51543
Domain	FYRN	KMT2C KMT2D	2.70e-04	5	98	2	PS51542
Domain	IPT	PLXNA3 PKHD1 PLXNB3	3.74e-04	27	98	3	SM00429
Domain	TIG	PLXNA3 PKHD1 PLXNB3	5.66e-04	31	98	3	PF01833
Domain	IPT	PLXNA3 PKHD1 PLXNB3	6.22e-04	32	98	3	IPR002909
Domain	-	PLXNA3 INSRR OBSL1 PHYHIP NOMO1 NOMO2 PKHD1 RIMBP2 NOMO3 IL6ST PLXNB3	7.06e-04	663	98	11	2.60.40.10
Domain	PTEN_C2	GAK TNS1	7.48e-04	8	98	2	PF10409
Domain	PTEN_C2	GAK TNS1	7.48e-04	8	98	2	SM01326
Domain	C2_TENSIN	GAK TNS1	7.48e-04	8	98	2	PS51182
Domain	Tensin_lipid_phosphatase_dom	GAK TNS1	7.48e-04	8	98	2	IPR029023
Domain	Tensin_C2-dom	GAK TNS1	7.48e-04	8	98	2	IPR014020
Domain	Plexin_cytopl	PLXNA3 PLXNB3	9.58e-04	9	98	2	PF08337
Domain	Plexin_cytoplasmic_RasGAP_dom	PLXNA3 PLXNB3	9.58e-04	9	98	2	IPR013548
Domain	Plexin	PLXNA3 PLXNB3	9.58e-04	9	98	2	IPR031148
Domain	PPASE_TENSIN	GAK TNS1	9.58e-04	9	98	2	PS51181
Domain	Ig-like_fold	PLXNA3 INSRR OBSL1 PHYHIP NOMO1 NOMO2 PKHD1 RIMBP2 NOMO3 IL6ST PLXNB3	1.18e-03	706	98	11	IPR013783
Domain	SET	NSD1 KMT2C KMT2D	1.29e-03	41	98	3	PF00856
Domain	Kinesin_motor_CS	KIFC2 KIF9 STARD9	1.29e-03	41	98	3	IPR019821
Domain	-	KIFC2 KIF9 STARD9	1.59e-03	44	98	3	3.40.850.10
Domain	Kinesin	KIFC2 KIF9 STARD9	1.59e-03	44	98	3	PF00225
Domain	KISc	KIFC2 KIF9 STARD9	1.59e-03	44	98	3	SM00129
Domain	KINESIN_MOTOR_1	KIFC2 KIF9 STARD9	1.59e-03	44	98	3	PS00411
Domain	Kinesin_motor_dom	KIFC2 KIF9 STARD9	1.59e-03	44	98	3	IPR001752
Domain	KINESIN_MOTOR_2	KIFC2 KIF9 STARD9	1.59e-03	44	98	3	PS50067
Domain	fn3	INSRR OBSL1 PHYHIP RIMBP2 IL6ST	1.64e-03	162	98	5	PF00041
Domain	SET	NSD1 KMT2C KMT2D	1.81e-03	46	98	3	SM00317
Domain	Inhibin_asu	BMP8B BMP8A	2.05e-03	13	98	2	IPR002405
Domain	SET_dom	NSD1 KMT2C KMT2D	2.30e-03	50	98	3	IPR001214
Domain	SET	NSD1 KMT2C KMT2D	2.30e-03	50	98	3	PS50280
Domain	FN3	INSRR OBSL1 PHYHIP RIMBP2 IL6ST	2.92e-03	185	98	5	SM00060
Domain	PKS_ER	TP53I3 FASN	3.12e-03	16	98	2	IPR020843
Domain	PKS_ER	TP53I3 FASN	3.12e-03	16	98	2	SM00829
Domain	FN3	INSRR OBSL1 PHYHIP RIMBP2 IL6ST	3.98e-03	199	98	5	PS50853
Domain	ADH_zinc_N	TP53I3 FASN	4.40e-03	19	98	2	PF00107
Domain	ADH_C	TP53I3 FASN	4.40e-03	19	98	2	IPR013149
Domain	FN3_dom	INSRR OBSL1 PHYHIP RIMBP2 IL6ST	4.90e-03	209	98	5	IPR003961
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	ZXDC PLXNA3 DGCR2 SPHK2 MORN1 VWA8 INPPL1 NSD1 CHD8 GRIN2D WRAP53 ANKHD1 KIFC2 DHX30 KMT2C BMP8B FASN KMT2D ZNF341 SCN8A SIPA1L2 DNMBP	6.28e-13	1105	100	22	35748872
Pubmed	Monoallelic yet combinatorial expression of variable exons of the protocadherin-alpha gene cluster in single neurons.	PCDHAC2 PCDHA12 PCDHA7 PCDHA5 PCDHA4	5.21e-10	15	100	5	15640798
Pubmed	Alpha protocadherins and Pyk2 kinase regulate cortical neuron migration and cytoskeletal dynamics via Rac1 GTPase and WAVE complex in mice.	PCDHAC2 PCDHA12 PCDHA7 PCDHA5 PCDHA4	1.07e-09	17	100	5	29911975
Pubmed	CNR/Pcdhalpha family in subplate neurons, and developing cortical connectivity.	PCDHAC2 PCDHA12 PCDHA7 PCDHA5 PCDHA4	1.48e-09	18	100	5	15570159
Pubmed	Genomic organization of the family of CNR cadherin genes in mice and humans.	PCDHAC2 PCDHA12 PCDHA7 PCDHA5 PCDHA4	1.48e-09	18	100	5	10662547
Pubmed	Developmental epigenetic modification regulates stochastic expression of clustered protocadherin genes, generating single neuron diversity.	PCDHAC2 PCDHA12 PCDHA7 PCDHA5 PCDHA4	7.23e-09	24	100	5	24698270
Pubmed	Diversity revealed by a novel family of cadherins expressed in neurons at a synaptic complex.	PCDHA12 PCDHA7 PCDHA5 PCDHA4	2.09e-08	11	100	4	9655502
Pubmed	Recurrent NOMO1 Gene Deletion Is a Potential Clinical Marker in Early-Onset Colorectal Cancer and Is Involved in the Regulation of Cell Migration.	NOMO1 NOMO2 NOMO3	2.31e-08	3	100	3	36011023
Pubmed	Silencing of nodal modulator 1 inhibits the differentiation of P19 cells into cardiomyocytes.	NOMO1 NOMO2 NOMO3	2.31e-08	3	100	3	25576386
Pubmed	Establishment of a conditional Nomo1 mouse model by CRISPR/Cas9 technology.	NOMO1 NOMO2 NOMO3	9.21e-08	4	100	3	31833031
Pubmed	A locus for autosomal recessive pseudoxanthoma elasticum, with penetrance of vascular symptoms in carriers, maps to chromosome 16p13.1.	NOMO1 NOMO2 NOMO3	9.21e-08	4	100	3	9267806
Pubmed	Clustered gamma-protocadherins regulate cortical interneuron programmed cell death.	PCDHAC2 PCDHA12 PCDHA7 PCDHA5 PCDHA4	6.61e-07	57	100	5	32633719
Pubmed	CTCF Governs the Identity and Migration of MGE-Derived Cortical Interneurons.	PCDHAC2 PCDHA12 PCDHA7 PCDHA5 PCDHA4	7.21e-07	58	100	5	30377227
Pubmed	Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.	GAK CAD INPPL1 OBSL1 ZNF217 NOMO2 DLD ATP1A1 EIF3I SIPA1L2 DNMBP	1.07e-06	588	100	11	38580884
Pubmed	Interaction with protocadherin-gamma regulates the cell surface expression of protocadherin-alpha.	PCDHA12 PCDHA7 PCDHA5 PCDHA4	1.25e-06	28	100	4	15347688
Pubmed	Nicalin and its binding partner Nomo are novel Nodal signaling antagonists.	NOMO1 NOMO2 NOMO3	1.28e-06	8	100	3	15257293
Pubmed	Comparative DNA sequence analysis of mouse and human protocadherin gene clusters.	PCDHAC2 PCDHA12 PCDHA7 PCDHA5 PCDHA4	1.60e-06	68	100	5	11230163
Pubmed	Hepatic lipase maturation: a partial proteome of interacting factors.	NOMO1 SLC25A3 NOMO2 NOMO3	1.91e-06	31	100	4	19136429
Pubmed	Substrate-driven assembly of a translocon for multipass membrane proteins.	NOMO1 NOMO2 NOMO3	1.91e-06	9	100	3	36261522
Pubmed	Molecular mechanisms governing Pcdh-gamma gene expression: evidence for a multiple promoter and cis-alternative splicing model.	PCDHAC2 PCDHA5 PCDHA4	1.91e-06	9	100	3	12154121
Pubmed	RSPO-LGR4 functions via IQGAP1 to potentiate Wnt signaling.	GAK CAD VWA8 SLC25A3 FASN PKHD1 ATP1A1	2.04e-06	202	100	7	24639526
Pubmed	A striking organization of a large family of human neural cadherin-like cell adhesion genes.	PCDHAC2 PCDHA12 PCDHA7 PCDHA5 PCDHA4	2.13e-06	72	100	5	10380929
Pubmed	Cadherin superfamily genes: functions, genomic organization, and neurologic diversity.	PCDHAC2 PCDHA12 PCDHA7 PCDHA5 PCDHA4	2.45e-06	74	100	5	10817752
Pubmed	Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members.	PCDHAC2 PCDHA12 PCDHA7 PCDHA5 PCDHA4	2.98e-06	77	100	5	10835267
Pubmed	Large exons encoding multiple ectodomains are a characteristic feature of protocadherin genes.	PCDHAC2 PCDHA12 PCDHA7 PCDHA5 PCDHA4	3.60e-06	80	100	5	10716726
Pubmed	An ER translocon for multi-pass membrane protein biogenesis.	NOMO1 NOMO2 NOMO3	3.74e-06	11	100	3	32820719
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	GAK CAD NSD1 CHD8 NCK1 ANKHD1 SLC25A3 KMT2C FASN KMT2D	4.30e-06	549	100	10	38280479
Pubmed	Proteins of the CNR family are multiple receptors for Reelin.	PCDHA7 PCDHA5 PCDHA4	4.98e-06	12	100	3	10612399
Pubmed	Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening.	PCDHA12 PCDHA7 PCDHA5 NCK1 GRIN2D KIFC2 BMP8B GRIP2	5.15e-06	329	100	8	17474147
Pubmed	Human Immunodeficiency Virus Type 1 Vpr Mediates Degradation of APC1, a Scaffolding Component of the Anaphase-Promoting Complex/Cyclosome.	OBSL1 NSD1 UBXN1 ANKHD1 MED24 MTCL1 SIPA1L2	6.69e-06	242	100	7	34011540
Pubmed	Mll3 and Mll4 Facilitate Enhancer RNA Synthesis and Transcription from Promoters Independently of H3K4 Monomethylation.	KMT2C KMT2D	8.18e-06	2	100	2	28483418
Pubmed	Human BMP8A suppresses luteinization of rat granulosa cells via the SMAD1/5/8 pathway.	BMP8B BMP8A	8.18e-06	2	100	2	31940275
Pubmed	The MLL3/4 H3K4 methyltransferase complex in establishing an active enhancer landscape.	KMT2C KMT2D	8.18e-06	2	100	2	34156443
Pubmed	Bone morphogenetic protein 8A plays a role in the maintenance of spermatogenesis and the integrity of the epididymis.	BMP8B BMP8A	8.18e-06	2	100	2	9463357
Pubmed	The gene encoding bone morphogenetic protein 8B is required for the initiation and maintenance of spermatogenesis in the mouse.	BMP8B BMP8A	8.18e-06	2	100	2	8682296
Pubmed	KMT2C/D COMPASS complex-associated diseases [KCDCOM-ADs]: an emerging class of congenital regulopathies.	KMT2C KMT2D	8.18e-06	2	100	2	31924266
Pubmed	Reduced Expression of Histone Methyltransferases KMT2C and KMT2D Correlates with Improved Outcome in Pancreatic Ductal Adenocarcinoma.	KMT2C KMT2D	8.18e-06	2	100	2	27280393
Pubmed	Loss of MLL3/4 decouples enhancer H3K4 monomethylation, H3K27 acetylation, and gene activation during embryonic stem cell differentiation.	KMT2C KMT2D	8.18e-06	2	100	2	36869380
Pubmed	Histone H3K4 monomethylation catalyzed by Trr and mammalian COMPASS-like proteins at enhancers is dispensable for development and viability.	KMT2C KMT2D	8.18e-06	2	100	2	28967912
Pubmed	The protective role of bone morphogenetic protein-8 in the glucocorticoid-induced apoptosis on bone cells.	BMP8B BMP8A	8.18e-06	2	100	2	21277400
Pubmed	Structure of the planar cell polarity cadherins Fat4 and Dachsous1.	FAT4 DCHS1	8.18e-06	2	100	2	36797229
Pubmed	Mammalian cadherins DCHS1-FAT4 affect functional cerebral architecture.	FAT4 DCHS1	8.18e-06	2	100	2	25930014
Pubmed	Crucial roles of mixed-lineage leukemia 3 and 4 as epigenetic switches of the hepatic circadian clock controlling bile acid homeostasis in mice.	KMT2C KMT2D	8.18e-06	2	100	2	25346535
Pubmed	Giant cadherins Fat and Dachsous self-bend to organize properly spaced intercellular junctions.	FAT4 DCHS1	8.18e-06	2	100	2	25355906
Pubmed	Association of KMT2C/D loss-of-function variants with response to immune checkpoint blockades in colorectal cancer.	KMT2C KMT2D	8.18e-06	2	100	2	36601880
Pubmed	Repression of rRNA transcription by PARIS contributes to Parkinson's disease.	CAD DHX30 SLC25A3 FASN PWP2 ATP1A1 EIF3I	1.43e-05	272	100	7	25315684
Pubmed	Functional analysis of candidate genes from genome-wide association studies of hearing.	SLC16A6 RIMBP2 CSMD1	1.52e-05	17	100	3	31927188
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	CAD NSD1 CHD8 ANKHD1 DHX30 FASN PWP2 DLD ATP1A1 EIF3I	1.93e-05	653	100	10	22586326
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	ZSWIM5 OBSL1 DHX30 STARD9 RIMBP2 MTCL1 SIPA1L2 PLXNB3	2.39e-05	407	100	8	12693553
Pubmed	Host E3 ligase HUWE1 attenuates the proapoptotic activity of the MERS-CoV accessory protein ORF3 by promoting its ubiquitin-dependent degradation.	CAD INPPL1 CHD8 ANKHD1 DHX30 SLC25A3 FASN PGLS NOMO3	2.45e-05	534	100	9	35032548
Pubmed	Evidence that Mothers-against-dpp-related 1 (Madr1) plays a role in the initiation and maintenance of spermatogenesis in the mouse.	BMP8B BMP8A	2.45e-05	3	100	2	9076678
Pubmed	Osteogenic activity of the fourteen types of human bone morphogenetic proteins (BMPs).	BMP8B BMP8A	2.45e-05	3	100	2	12925636
Pubmed	Remodeling of the enhancer landscape during macrophage activation is coupled to enhancer transcription.	KMT2C KMT2D	2.45e-05	3	100	2	23932714
Pubmed	Mutations of PTCH1, MLL2, and MLL3 are not frequent events in hepatoblastoma.	KMT2C KMT2D	2.45e-05	3	100	2	22183980
Pubmed	Requirement of Bmp8b for the generation of primordial germ cells in the mouse.	BMP8B BMP8A	2.45e-05	3	100	2	10894154
Pubmed	BMP8B increases brown adipose tissue thermogenesis through both central and peripheral actions.	BMP8B BMP8A	2.45e-05	3	100	2	22579288
Pubmed	Mutation in Bmp7 exacerbates the phenotype of Bmp8a mutants in spermatogenesis and epididymis.	BMP8B BMP8A	2.45e-05	3	100	2	11784057
Pubmed	HOXC6 Is transcriptionally regulated via coordination of MLL histone methylase and estrogen receptor in an estrogen environment.	KMT2C KMT2D	2.45e-05	3	100	2	21683083
Pubmed	In vitro degradation of insulin-like peptide 3 by insulin-degrading enzyme.	INSL3 IDE	2.45e-05	3	100	2	20082125
Pubmed	Estrogen mediated epithelial proliferation in the uterus is directed by stromal Fgf10 and Bmp8a.	BMP8B BMP8A	2.45e-05	3	100	2	25451979
Pubmed	A Genome-Wide CRISPR Screen Identifies Genes Critical for Resistance to FLT3 Inhibitor AC220.	PCDHAC2 PCDHA12 PCDHA7 PCDHA5 PCDHA4	2.50e-05	119	100	5	28625976
Pubmed	Interactomes of Glycogen Synthase Kinase-3 Isoforms.	MIA3 INPPL1 CEP43 SLC25A3 MTCL1 SIPA1L2	3.27e-05	209	100	6	36779422
Pubmed	Biochemical Reduction of the Topology of the Diverse WDR76 Protein Interactome.	CAD VWA8 CHD8 SLC25A3 DLD ATP1A1	4.24e-05	219	100	6	31353912
Pubmed	Crucial roles for interactions between MLL3/4 and INI1 in nuclear receptor transactivation.	KMT2C KMT2D	4.89e-05	4	100	2	19221051
Pubmed	Cancer gene mutation frequencies for the U.S. population.	KMT2C KMT2D	4.89e-05	4	100	2	34645806
Pubmed	MLL3/MLL4 are required for CBP/p300 binding on enhancers and super-enhancer formation in brown adipogenesis.	KMT2C KMT2D	4.89e-05	4	100	2	28398509
Pubmed	Nck adapters are involved in the formation of dorsal ruffles, cell migration, and Rho signaling downstream of the platelet-derived growth factor beta receptor.	PDGFB NCK1	4.89e-05	4	100	2	18765673
Pubmed	Characterization and chromosomal localization of PTPRO, a novel receptor protein tyrosine phosphatase, expressed in hematopoietic stem cells.	BMP8B BMP8A	4.89e-05	4	100	2	9434160
Pubmed	Evidence that mouse Bmp8a (Op2) and Bmp8b are duplicated genes that play a role in spermatogenesis and placental development.	BMP8B BMP8A	4.89e-05	4	100	2	8843393
Pubmed	A subset of mixed lineage leukemia proteins has plant homeodomain (PHD)-mediated E3 ligase activity.	KMT2C KMT2D	4.89e-05	4	100	2	23129768
Pubmed	The MLL3/MLL4 branches of the COMPASS family function as major histone H3K4 monomethylases at enhancers.	KMT2C KMT2D	4.89e-05	4	100	2	24081332
Pubmed	Identification and classification of 16 new kinesin superfamily (KIF) proteins in mouse genome.	KIFC2 KIF9 STARD9	5.07e-05	25	100	3	9275178
Pubmed	The DNA sequence and comparative analysis of human chromosome 5.	PCDHA12 PCDHA7 PCDHA5 PCDHA4	6.69e-05	75	100	4	15372022
Pubmed	Selective binding of the PHD6 finger of MLL4 to histone H4K16ac links MLL4 and MOF.	KMT2C KMT2D	8.14e-05	5	100	2	31127101
Pubmed	Mutations in genes encoding the cadherin receptor-ligand pair DCHS1 and FAT4 disrupt cerebral cortical development.	FAT4 DCHS1	8.14e-05	5	100	2	24056717
Pubmed	The Expression of Water and Ion Channels in Diffuse Alveolar Damage Is Not Dependent on DAD Etiology.	AQP1 ATP1A1	8.14e-05	5	100	2	27835672
Pubmed	Mapping to chromosomes 1 and 12 of mouse homologs of human protein tyrosine phosphatase, receptor-type, related genes encoding pancreatic beta cell autoantigens.	PTPRN TNS1	8.14e-05	5	100	2	9383296
Pubmed	MLL3/MLL4-Associated PAGR1 Regulates Adipogenesis by Controlling Induction of C/EBPβ and C/EBPδ.	KMT2C KMT2D	8.14e-05	5	100	2	32601106
Pubmed	A PTIP-PA1 subcomplex promotes transcription for IgH class switching independently from the associated MLL3/MLL4 methyltransferase complex.	KMT2C KMT2D	8.14e-05	5	100	2	26744420
Pubmed	The genomic organization of a human creatine transporter (CRTR) gene located in Xq28.	PLXNB3 PDZD4	8.14e-05	5	100	2	8661155
Pubmed	Common deletion variants causing protocadherin-α deficiency contribute to the complex genetics of BAV and left-sided congenital heart disease.	PCDHA12 PCDHA7	8.14e-05	5	100	2	34888534
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	CAD NSD1 CHD8 ZNF217 WRAP53 ANKHD1 DHX30 NOMO1 SLC25A3 MED24 KMT2C PWP2 EIF3I DNMBP	9.76e-05	1497	100	14	31527615
Pubmed	An FBXW7-ZEB2 axis links EMT and tumour microenvironment to promote colorectal cancer stem cells and chemoresistance.	NOMO1 NOMO2 NOMO3	1.18e-04	33	100	3	30783098
Pubmed	A Functional Link between AMPK and Orexin Mediates the Effect of BMP8B on Energy Balance.	BMP8B FASN	1.22e-04	6	100	2	27524625
Pubmed	Conserved chromosomal location and genomic structure of human and mouse fatty-acid amide hydrolase genes and evaluation of clasper as a candidate neurological mutation.	BMP8B BMP8A	1.22e-04	6	100	2	9878243
Pubmed	Colocalization of BMP 7 and BMP 2 RNAs suggests that these factors cooperatively mediate tissue interactions during murine development.	BMP8B BMP8A	1.22e-04	6	100	2	7605753
Pubmed	CHARGE and Kabuki syndromes: a phenotypic and molecular link.	CHD8 KMT2D	1.22e-04	6	100	2	24705355
Pubmed	Mammalian Fat and Dachsous cadherins regulate apical membrane organization in the embryonic cerebral cortex.	FAT4 DCHS1	1.22e-04	6	100	2	19506035
Pubmed	Coactivator as a target gene specificity determinant for histone H3 lysine 4 methyltransferases.	KMT2C KMT2D	1.22e-04	6	100	2	17021013
Pubmed	Sequential genome-wide CRISPR-Cas9 screens identify genes regulating cell-surface expression of tetraspanins.	VWA8 INSRR ZBTB8B NSD1 IDE ZNF341 SCN8A DLD RIMBP2 CSMD1	1.45e-04	832	100	10	36724073
Pubmed	Structural insights into trans-histone regulation of H3K4 methylation by unique histone H4 binding of MLL3/4.	KMT2C KMT2D	1.70e-04	7	100	2	30604749
Pubmed	Clustered PHD domains in KMT2/MLL proteins are attracted by H3K4me3 and H3 acetylation-rich active promoters and enhancers.	KMT2C KMT2D	1.70e-04	7	100	2	36598580
Pubmed	Expression of mouse dchs1, fjx1, and fat-j suggests conservation of the planar cell polarity pathway identified in Drosophila.	FAT4 DCHS1	1.70e-04	7	100	2	16059920
Pubmed	Dchs1-Fat4 regulation of polarized cell behaviours during skeletal morphogenesis.	FAT4 DCHS1	1.70e-04	7	100	2	27145737
Pubmed	The Bmp8 gene is expressed in developing skeletal tissue and maps near the Achondroplasia locus on mouse chromosome 4.	BMP8B BMP8A	1.70e-04	7	100	2	9070944
Pubmed	ASCOM controls farnesoid X receptor transactivation through its associated histone H3 lysine 4 methyltransferase activity.	KMT2C KMT2D	1.70e-04	7	100	2	19556342
Pubmed	Characterisation of the mouse diabetes susceptibilty locus Nidd/SJL: islet cell destruction, interaction with the obesity QTL Nob1, and effect of dietary fat.	BMP8B BMP8A	1.70e-04	7	100	2	12107726
Pubmed	14-3-3-affinity purification of over 200 human phosphoproteins reveals new links to regulation of cellular metabolism, proliferation and trafficking.	IDE UBXN1 ALG2 FASN PGLS	2.07e-04	186	100	5	14744259
Pubmed	The expression of plexins during mouse embryogenesis.	PLXNA3 PLXNB3	2.27e-04	8	100	2	15661641
Pubmed	Four enzymes cooperate to displace histone H1 during the first minute of hormonal gene activation.	KMT2C KMT2D	2.27e-04	8	100	2	21447625
Interaction	TOP3B interactions	ZXDC PLXNA3 DGCR2 SPHK2 CAD MORN1 VWA8 INPPL1 NSD1 CHD8 GRIN2D WRAP53 ANKHD1 KIFC2 DHX30 KMT2C BMP8B FASN KMT2D ZNF341 SCN8A SIPA1L2 DNMBP	5.18e-07	1470	99	23	int:TOP3B
Interaction	PCDHA10 interactions	PCDHA12 PCDHA7 PCDHA5 PCDHA4	3.74e-06	22	99	4	int:PCDHA10
Cytoband	5q31	PCDHAC2 PCDHA12 PCDHA7 PCDHA5 PCDHA4	5.63e-06	115	100	5	5q31
Cytoband	Ensembl 112 genes in cytogenetic band chr5q31	PCDHAC2 PCDHA12 PCDHA7 PCDHA5 PCDHA4 ANKHD1	5.08e-05	298	100	6	chr5q31
Cytoband	Ensembl 112 genes in cytogenetic band chr2q35	OBSL1 PTPRN ASIC4 TNS1	1.89e-04	129	100	4	chr2q35
Cytoband	Xq28	PLXNA3 F8 PLXNB3 PDZD4	6.15e-04	176	100	4	Xq28
Cytoband	4p16	HGFAC GAK	6.25e-04	17	100	2	4p16
Cytoband	Ensembl 112 genes in cytogenetic band chrXq28	PLXNA3 F8 PLXNB3 PDZD4	1.25e-03	213	100	4	chrXq28
Cytoband	11q13	INPPL1 PITPNM1 CCS	2.23e-03	118	100	3	11q13
Cytoband	1p35.1	ZBTB8B DCDC2B	2.23e-03	32	100	2	1p35.1
Cytoband	Ensembl 112 genes in cytogenetic band chr1p35	ZBTB8B DCDC2B EIF3I	3.40e-03	137	100	3	chr1p35
GeneFamily	Clustered protocadherins	PCDHAC2 PCDHA12 PCDHA7 PCDHA5 PCDHA4	5.92e-06	64	73	5	20
GeneFamily	Zinc fingers C2H2-type\|Lysine methyltransferases\|PR/SET domain family	NSD1 KMT2C KMT2D	3.45e-04	34	73	3	487
GeneFamily	DNAJ (HSP40) heat shock proteins\|C2 tensin-type domain containing	GAK TNS1	4.43e-04	8	73	2	837
GeneFamily	Plexins	PLXNA3 PLXNB3	5.68e-04	9	73	2	683
GeneFamily	Kinesins\|Pleckstrin homology domain containing	KIFC2 KIF9 STARD9	8.46e-04	46	73	3	622
GeneFamily	Bone morphogenetic proteins\|Astacins	BMP8B BMP8A	8.64e-04	11	73	2	455
GeneFamily	Cadherin related	FAT4 DCHS1	2.10e-03	17	73	2	24
GeneFamily	PDZ domain containing	USH1C GRIP2 SIPA1L2 PDZD4	3.33e-03	152	73	4	1220
GeneFamily	PHD finger proteins	NSD1 KMT2C KMT2D	5.77e-03	90	73	3	88
Coexpression	PEREZ_TP53_TARGETS	PLIN4 ZXDC ANKRD65 GAK TP53I3 USH1C CEP43 F8 KIF9 ZNF341 AUTS2 RIMBP2 MTCL1 SIPA1L2 TNS1 CCS	9.37e-06	1201	98	16	M4391
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L1-3_VIP_ZNF322P1\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	FAT4 PDE3A OBSL1 GRIN2D RYR3 GRIP2 ASIC4	2.06e-07	185	100	7	0b5a0df58ae2ad8261f40f152775747af4f3937a
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1-3_VIP_ACHE\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	HGFAC FAT4 PDE3A RYR3 GRIP2 ASIC4	2.37e-06	170	100	6	36dbbdb13f69307afd2122ff051b2980850c1f00
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L1-3_VIP_ZNF322P1\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	FAT4 PDE3A GRIN2D RYR3 GRIP2 ASIC4	3.40e-06	181	100	6	062f00736eed96e4f4327615d093558dd7d82b20
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_2\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	HGFAC FAT4 PDE3A GRIN2D GRIP2 ASIC4	3.51e-06	182	100	6	420a8fd30543e37a66ba0786215d056d308660d0
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	HGFAC FAT4 PDE3A GRIN2D GRIP2 ASIC4	3.62e-06	183	100	6	e3ffef2b57dc5b96466dccc9cd54ba326ccf378a
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	HGFAC FAT4 PDE3A GRIN2D GRIP2 ASIC4	3.85e-06	185	100	6	16e9ccea0e3b95d90dc48ef74206c805681dac0b
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	HGFAC FAT4 PDE3A GRIN2D GRIP2 ASIC4	3.85e-06	185	100	6	027020754dbf71b0034791f9a34ae795e3b85f81
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1_ADARB2_ADAM33\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	HGFAC PDE3A GRIN2D GRIP2 ASIC4 SIPA1L2	3.85e-06	185	100	6	487fa382232564f075960899d50afa0edae5d258
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	HGFAC FAT4 PDE3A GRIN2D GRIP2 ASIC4	3.85e-06	185	100	6	08fad1e3c3cc5f1c3eb6629a49c094b628e75a92
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_2\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	HGFAC FAT4 PDE3A GRIN2D GRIP2 ASIC4	3.85e-06	185	100	6	cefd81adb480c027545a5c78dcd05669783717f4
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_2\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	HGFAC FAT4 PDE3A GRIN2D GRIP2 ASIC4	4.10e-06	187	100	6	ae2ee6f8e5c37cb88a67f3e742cf86e57657bfaf
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_2\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	HGFAC FAT4 PDE3A GRIN2D GRIP2 ASIC4	4.63e-06	191	100	6	764c3a8829ae1253a0790744138266e81fc075ec
ToppCell	COPD-Endothelial-VE_Arterial\|Endothelial / Disease state, Lineage and Cell class	PDE3A NOMO1 NOMO2 ATP1A1 CSMD1 NOMO3	4.63e-06	191	100	6	ef16ad1c1cd2c0c0377957398c98775b62a81754
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	HGFAC FAT4 PDE3A GRIN2D GRIP2 ASIC4	4.77e-06	192	100	6	3abee376c37c3646da33ac381aa63d50a01607a6
ToppCell	Control-Endothelial-VE_Arterial\|Endothelial / Disease state, Lineage and Cell class	PDE3A NOMO1 NOMO2 ATP1A1 CSMD1 NOMO3	4.77e-06	192	100	6	7e89b9125e8b85f6be85eeccef5c8644647ab0e1
ToppCell	Neuronal-Inhibitory-iA-iA_3(VIP)-VIP_3\|Neuronal / cells hierarchy compared to all cells using T-Statistic	HGFAC FAT4 PDE3A GRIN2D GRIP2 ASIC4	6.03e-06	200	100	6	7e51715525fdb001b7042b2bfcb9de81ecb5e4ee
ToppCell	Neuronal-Inhibitory-iA-iA_3(VIP)-VIP_3-CHRM2\|Neuronal / cells hierarchy compared to all cells using T-Statistic	FAT4 PDE3A OBSL1 RYR3 GRIP2 ASIC4	6.03e-06	200	100	6	501a3b93624df463458a35d3e6648d4ccc941724
ToppCell	Neuronal-Inhibitory-iA-iA_3(VIP)-VIP_3-CHRM2-L1-3\|Neuronal / cells hierarchy compared to all cells using T-Statistic	FAT4 PDE3A OBSL1 RYR3 GRIP2 ASIC4	6.03e-06	200	100	6	d1f36a8232411933b1494168ec912fd0e5246428
ToppCell	Neuronal-Inhibitory-iA\|Neuronal / cells hierarchy compared to all cells using T-Statistic	HGFAC FAT4 PDE3A GRIN2D GRIP2 ASIC4	6.03e-06	200	100	6	5ef4a3dc18a44292184a59ced916183c0699b01e
ToppCell	Neuronal-Inhibitory-iA-iA_3(VIP)\|Neuronal / cells hierarchy compared to all cells using T-Statistic	HGFAC FAT4 PDE3A GRIN2D GRIP2 ASIC4	6.03e-06	200	100	6	75649534a98bc738fca62d071de0978dc61eb24f
ToppCell	3'-Distal_airway-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	MORN1 ZSWIM5 DCDC2B PITPNM1 KIF9	3.45e-05	164	100	5	9e16e52f5a634585f26021bcce9b5d5992ff6db0
ToppCell	Adult-Endothelial-endothelial_cell_of_artery-D122\|Adult / Lineage, Cell type, age group and donor	PDE3A F8 RYR3 GRIP2 CSMD1	3.87e-05	168	100	5	8c3e1e45b422813bcdfa4273b1167db649a312f5
ToppCell	368C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_1.5\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	DGCR2 INSL3 GZMH DNMBP ARMH4	3.87e-05	168	100	5	94cded2e953c0970bf2f3dbe0ce46bd77a5ed8c7
ToppCell	tumor_Lung-Endothelial_cells-EPCs\|tumor_Lung / Location, Cell class and cell subclass	ZSWIM5 FAM171B AQP1 F8 PTPRN	4.96e-05	177	100	5	f8b152c09d56a97e8c0482fb1a3964c05f9dc8c5
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	HGFAC FAT4 GRIN2D GRIP2 ASIC4	5.23e-05	179	100	5	97ba67a856680f24846244c0b92c886cc0e79537
ToppCell	COVID-19-kidney-PLVAP+EC\|COVID-19 / Disease (COVID-19 only), tissue and cell type	GAK F8 SLC16A6 SIPA1L2 TNS1	5.37e-05	180	100	5	493cf8d1a8f2a1ed2672f394a0338b110fd81d88
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1_SST_CXCL14\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	FAT4 PDE3A GRIN2D RYR3 GRIP2	5.37e-05	180	100	5	b6efdb4d319ef6f87f559acd974e5a71b06a2322
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L3_VIP_CBLN1\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	FAT4 PDE3A RYR3 GRIP2 ASIC4	5.51e-05	181	100	5	7846c7b33d1b89364c5a704edaa86520db731c89
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	HGFAC FAT4 GRIN2D GRIP2 ASIC4	5.66e-05	182	100	5	7dc61e901428cea04f00ebb0939a44d21a6145c6
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L1-3_VIP_ZNF322P1\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	FAT4 PDE3A RYR3 GRIP2 ASIC4	5.66e-05	182	100	5	d3a037268f026eb2f84428b1821022503cef7756
ToppCell	cellseq2-Immune-Lymphocytic_T/NK-Lymphocytic_T/NK-NK\|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	ADAM8 SLC16A6 KLHL15 GZMH PDZD4	5.66e-05	182	100	5	8ccffcbae28c374fd4161fb0d4cf2c49fae557f6
ToppCell	15-Trachea-Epithelial-Multiciliated_precursor\|Trachea / Age, Tissue, Lineage and Cell class	WFDC6 CEP43 PITPNM1 ZNF469 KIF9	6.11e-05	185	100	5	9a8b8360d99375b726ca8e3c9a3f9b08919892d7
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_2\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	HGFAC FAT4 GRIN2D GRIP2 ASIC4	6.11e-05	185	100	5	bdfa8c284bbc5e85c806327fbb7778cf16242a38
ToppCell	facs-Heart-LA-24m-Myeloid-macrophage\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HGFAC SLC39A4 USH1C SCN8A MTCL1	6.27e-05	186	100	5	246503fd4e6ae24041c606b069eb5fb313e60f73
ToppCell	facs-Heart-LA-24m-Myeloid-macrophage\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HGFAC SLC39A4 USH1C SCN8A MTCL1	6.27e-05	186	100	5	ef93ac469eb4f63db036f14b442c1503b8c6de38
ToppCell	Adult-Endothelial-endothelial_cell_of_artery\|Adult / Lineage, Cell type, age group and donor	PDE3A F8 RYR3 GRIP2 CSMD1	6.27e-05	186	100	5	2d1c4ea2e401db89971582ee54618a8b0c81b8ac
ToppCell	5'-Airway_Nasal-Endothelial-Blood_vessel_EC-vein_endothelial_cell\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ZXDC CHD8 FAM171B DCHS1 SIPA1L2	6.59e-05	188	100	5	524d1d928c9386acf20e53d31894107dd7290dc7
ToppCell	5'-Airway_Nasal-Endothelial-Blood_vessel_EC-vein_endothelial_cell-EC_venous_systemic-EC_venous_systemic_L.2.2.0.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ZXDC CHD8 FAM171B DCHS1 SIPA1L2	6.59e-05	188	100	5	1b57995d70cf81212e8d46dfaf44dbaf9c7bc4d5
ToppCell	5'-Airway_Nasal-Endothelial-Blood_vessel_EC\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ZXDC CHD8 FAM171B DCHS1 SIPA1L2	6.59e-05	188	100	5	cd2d1f8e43c252dd8730a5758458ef63e7ffc836
ToppCell	5'-Airway_Nasal-Endothelial-Blood_vessel_EC-vein_endothelial_cell-EC_venous_systemic\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ZXDC CHD8 FAM171B DCHS1 SIPA1L2	6.59e-05	188	100	5	f5a2f324f3f6c5078d57130392d3f1ba74f29094
ToppCell	5'-Airway_Nasal-Endothelial\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ZXDC CHD8 FAM171B DCHS1 SIPA1L2	6.59e-05	188	100	5	6c9d5e4014f807149328ff4eabd5e86dfe18094d
ToppCell	COVID-19-Heart-EC_(POSTN)\|COVID-19 / Disease (COVID-19 only), tissue and cell type	PDE3A AQP1 F8 CSMD1 IL6ST	6.76e-05	189	100	5	7346c1112e2e155dbd71b6dbc80e680fd262a691
ToppCell	Neuroendocrine-neuroendo-2-Calca\|World / Class top	INSRR FAM171B SLC16A6 SCN8A RIMBP2	6.76e-05	189	100	5	6baa9a74560121cc008bb8fa9b2b7a335b3aeee0
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L1_LAMP5_NDNF\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	HGFAC GRIN2D RIMBP2 GRIP2 IL6ST	7.11e-05	191	100	5	7b386512284dfaa0e95358b28ee82632ee965e64
ToppCell	facs-Liver-Liver_non-hepato/SCs_st-18m-Endothelial-nan\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	AQP1 F8 DCHS1 TNS1 IL6ST	7.28e-05	192	100	5	6806a1a9fe00395dc1abc3e0124b4261dc701f31
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	FAT4 PDE3A GRIN2D GRIP2 ASIC4	7.28e-05	192	100	5	6a252e298f8a454623fa9c1c893a7a45a886d694
ToppCell	facs-Lung-ENDOMUCIN-18m-Endothelial-Vein_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PDE3A AQP1 F8 BMP8B IL6ST	7.65e-05	194	100	5	e8102c8811333f04de7280b7d9b6b85cebb815ac
ToppCell	facs-Lung-ENDOMUCIN-18m-Endothelial-vein_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PDE3A AQP1 F8 BMP8B IL6ST	7.65e-05	194	100	5	4b0d63babb8a46ff45731d5f82b29ccaf6c9402d
ToppCell	3'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_II_pneumocyte-AT2-AT2_L.0.1.2.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	NAPSA SLC39A4 AQP1 FASN CDH15	7.83e-05	195	100	5	643a360d3358bad52f0737c0d55195b69007c29b
ToppCell	droplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MIA3 INSRR NSD1 KMT2C PTPRN	7.83e-05	195	100	5	3e519cffa6144a62b06124642a14c9ff39b76554
ToppCell	10x_3'_v2v3-Neoplastic-Differentiated-like-MES-like-MES-like_hypoxia_independent-F\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	RYR3 SCN8A AUTS2 ASIC4 CDH15	8.03e-05	196	100	5	b8b9801181d7604871b48aebacb295d0a57a5eaf
ToppCell	LPS_anti-TNF-Epithelial_alveolar-AT_1-Differentiating_AT2\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	NAPSA KIFC2 PKHD1 MTCL1 ATP1A1	8.22e-05	197	100	5	3d13a4f2e86422900ee2194e8a1fd1cf9750d5d3
ToppCell	5'-Parenchyma_lung-Endothelial-Blood_vessel_EC-pulmonary_artery_endothelial_cell-EC_arterial-EC_arterial_L.2.4.1.3\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	FAT4 PDGFB AQP1 F8 IL6ST	8.42e-05	198	100	5	d5990cab01de6e6f3757f5a50ef70ced711bb1fa
ToppCell	Tracheal-NucSeq-Immune_Myeloid-Dendritic_cell-DC_activated\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	NAPSA PDGFB GRIN2D ADAM8 KLHL15	8.62e-05	199	100	5	6dc446a5d183b01bdf227e45bd88d0b3d8b1c56a
ToppCell	LPS_only-Epithelial_alveolar-AT_1-2_Progenitor-AT2_Progenitor\|LPS_only / Treatment groups by lineage, cell group, cell type	NAPSA OBSL1 SLC39A4 FASN ATP1A1	8.62e-05	199	100	5	7b21447bb39cdba37539a12cb475f463010fc23f
ToppCell	Neuronal-Inhibitory-iA-iA_1(SST_PAX6)-NMBR\|Neuronal / cells hierarchy compared to all cells using T-Statistic	HGFAC GRIN2D RIMBP2 GRIP2 IL6ST	8.83e-05	200	100	5	862db57d043bdf3cb059fbfc8b29bc1eafdf64ec
ToppCell	Neuronal-Inhibitory-iA-iA_3(VIP)-VIP_3-LBH\|Neuronal / cells hierarchy compared to all cells using T-Statistic	HGFAC FAT4 PDE3A RYR3 ASIC4	8.83e-05	200	100	5	0ff2607c58bc929e203f407ecf3605e0b21bfa90
ToppCell	Neuronal-Inhibitory-iA-iA_1(SST_PAX6)-NMBR--L1\|Neuronal / cells hierarchy compared to all cells using T-Statistic	HGFAC GRIN2D RIMBP2 GRIP2 IL6ST	8.83e-05	200	100	5	a91345f268f13170c27309333603eb82400c9947
ToppCell	Neuronal-Inhibitory-iA-iA_3(VIP)-VIP_3-LBH-L1-2\|Neuronal / cells hierarchy compared to all cells using T-Statistic	HGFAC FAT4 PDE3A RYR3 ASIC4	8.83e-05	200	100	5	de23a5d22d94935802b5b84a9e029b3f62c57028
ToppCell	Neuronal-Inhibitory-iA-iA_1(SST_PAX6)-SST\|Neuronal / cells hierarchy compared to all cells using T-Statistic	FAT4 PDE3A GRIN2D GRIP2 ASIC4	8.83e-05	200	100	5	53d5e427f0cbf5cf0b63efe4ec01da302f555704
ToppCell	Neuronal-Inhibitory-iA-iA_1(SST_PAX6)-NMBR-\|Neuronal / cells hierarchy compared to all cells using T-Statistic	HGFAC GRIN2D RIMBP2 GRIP2 IL6ST	8.83e-05	200	100	5	d416a7be1a4e6232fb58a9687774da24821f1fdd
Disease	diabetes mellitus (implicated_via_orthology)	INSRR BMP8B PTPRN BMP8A	1.43e-06	26	95	4	DOID:9351 (implicated_via_orthology)
Disease	1,5 anhydroglucitol measurement	PCDHA12 PCDHA7 PCDHA5 PCDHA4	2.25e-06	29	95	4	EFO_0008009
Disease	visceral adipose tissue measurement, body mass index	PCDHAC2 PCDHA12 PCDHA7 PCDHA5 PCDHA4	9.33e-06	87	95	5	EFO_0004340, EFO_0004765
Disease	Van Maldergem Wetzburger Verloes syndrome	FAT4 DCHS1	1.03e-05	2	95	2	C1832390
Disease	Kleefstra syndrome 2 (implicated_via_orthology)	KMT2C KMT2D	1.03e-05	2	95	2	DOID:0080598 (implicated_via_orthology)
Disease	Van Maldergem syndrome	FAT4 DCHS1	1.03e-05	2	95	2	cv:C1832390
Disease	Periventricular gray matter heterotopia	FAT4 DCHS1	1.03e-05	2	95	2	C1849173
Disease	Heterotopia, Periventricular, Autosomal Recessive	FAT4 DCHS1	3.07e-05	3	95	2	C1842563
Disease	obesity (implicated_via_orthology)	SPHK2 FAT4 BMP8B DCHS1 BMP8A PLXNB3	7.07e-05	215	95	6	DOID:9970 (implicated_via_orthology)
Disease	Intellectual Disability	NSD1 CHD8 GRIN2D KMT2C FASN KLHL15 SCN8A ATP1A1	1.00e-04	447	95	8	C3714756
Disease	Choledochal Cyst, Type I	AQP1 PKHD1	1.02e-04	5	95	2	C0009439
Disease	Choledochal Cyst, Type II	AQP1 PKHD1	1.02e-04	5	95	2	C1257796
Disease	Choledochal Cyst, Type III	AQP1 PKHD1	1.02e-04	5	95	2	C1257797
Disease	Choledochal Cyst, Type IV	AQP1 PKHD1	1.02e-04	5	95	2	C1257798
Disease	Choledochal Cyst, Type V	AQP1 PKHD1	1.02e-04	5	95	2	C1257799
Disease	Choledochal Cyst	AQP1 PKHD1	1.02e-04	5	95	2	C0008340
Disease	aspartate aminotransferase to alanine aminotransferase ratio	SLC39A4 NCK1 KIFC2 ZNF341 AUTS2 DNMBP	1.26e-04	239	95	6	EFO_0010934
Disease	Squamous cell carcinoma of esophagus	FAT4 KMT2C FASN KMT2D	2.57e-04	95	95	4	C0279626
Disease	Adenoid Cystic Carcinoma	INSRR NSD1 AQP1 KMT2C	3.12e-04	100	95	4	C0010606
Disease	Autosomal Recessive Polycystic Kidney Disease	AQP1 PKHD1	3.64e-04	9	95	2	C0085548
Disease	post-traumatic stress disorder	PCDHA7 PCDHA5 PCDHA4 CSMD1 SIPA1L2	5.03e-04	202	95	5	EFO_0001358
Disease	autosomal recessive polycystic kidney disease (biomarker_via_orthology)	AQP1 PKHD1	5.54e-04	11	95	2	DOID:0110861 (biomarker_via_orthology)
Disease	rheumatoid arthritis (implicated_via_orthology)	KMT2C IL6ST	6.63e-04	12	95	2	DOID:7148 (implicated_via_orthology)
Disease	squamous cell carcinoma, multiple keratinocyte carcinoma susceptibility measurement, basal cell carcinoma	PKHD1 CSMD1	7.82e-04	13	95	2	EFO_0000707, EFO_0004193, EFO_0007932
Disease	tea consumption measurement	MIA3 PHYHIP PKHD1 CSMD1	8.16e-04	129	95	4	EFO_0010091
Disease	Profound Mental Retardation	NSD1 CHD8 FASN SCN8A	1.08e-03	139	95	4	C0020796
Disease	Mental Retardation, Psychosocial	NSD1 CHD8 FASN SCN8A	1.08e-03	139	95	4	C0025363
Disease	Mental deficiency	NSD1 CHD8 FASN SCN8A	1.08e-03	139	95	4	C0917816
Disease	congenital heart disease (implicated_via_orthology)	CHD8 KMT2C KMT2D	1.45e-03	69	95	3	DOID:1682 (implicated_via_orthology)
Disease	vital capacity	PDE3A PDGFB PCDHA12 PCDHA7 PCDHA5 PCDHA4 ZNF341 AUTS2 MTCL1 ASIC4 TNS1	2.08e-03	1236	95	11	EFO_0004312
Disease	pulmonary hypertension (biomarker_via_orthology)	PDE3A PDGFB RYR3	2.22e-03	80	95	3	DOID:6432 (biomarker_via_orthology)
Disease	neuroticism measurement, cognitive function measurement	PCDHA12 PCDHA7 PCDHA5 PCDHA4 MED24 AUTS2 CSMD1	2.38e-03	566	95	7	EFO_0007660, EFO_0008354
Disease	post-traumatic stress disorder symptom measurement	PCDHA7 PCDHA5 PCDHA4	2.38e-03	82	95	3	EFO_0008535
Disease	smoking status measurement, chronic obstructive pulmonary disease	MED24 MTCL1 TNS1	2.91e-03	88	95	3	EFO_0000341, EFO_0006527
Disease	glycerol measurement	FAT4 SIPA1L2	3.17e-03	26	95	2	EFO_0010115
Disease	triacylglycerol 48:0 measurement	MORN1 CSMD1	3.17e-03	26	95	2	EFO_0010403

Protein segments in the cluster

Peptide	Gene	Start	Entry
EGSLDLALEGGVDSP	USH1C	461	Q9Y6N9
VTGGILGPGNHLLDS	CHD8	2186	Q9HCK8
LEIHDGGDVTAPRLG	CSMD1	1856	Q96PZ7
VFDLLILGVGPDGHT	PGLS	141	O95336
LGAEPLEIHGTLATG	BRICD5	216	Q6PL45
ALGLPEGETHTGTAL	ARMH4	366	Q86TY3
LLTPGAGTEEIIGGH	GZMH	11	P20718
NGTISLLGPLDVHAG	FAT4	946	Q6V0I7
GSAPLAIGLSVALGH	AQP1	166	P29972
VGPVFLGHRDELEGT	DNMBP	851	Q6XZF7
DLHLIEPLDEGGEGG	ADAM8	136	P78325
TDLVLHIDARGEPGG	DHX30	656	Q7L2E3
LGGGHAELPQLTLSV	NSD1	1361	Q96L73
LLLSGVGPAHGSEDI	NOMO3	21	P69849
LGLEASGHVAELGPG	TP53I3	61	Q53FA7
EGEHPETLSRLGELG	MTCL1	1066	Q9Y4B5
LGALHGQEDTPGGLL	MORN1	331	Q5T089
STPGGDLELVVHLSG	OBSL1	1281	O75147
SVHLEEAGILRAGPG	PCDHA7	806	Q9UN72
LGPSGGPAHELELEA	DCHS1	956	Q96JQ0
GPAHELELEARDGGS	DCHS1	961	Q96JQ0
LLLSGVGPAHGSEDI	NOMO2	21	Q5JPE7
RLAALGPEGAHGDTT	PTPRN	611	Q16849
LVHDGLGDLRSSSPG	SLC25A3	21	Q00325
HEEGDGLTDGPARLL	KMT2C	4406	Q8NEZ4
TEEGDSPLGDHVGSL	NCK1	161	P16333
GLEGGQTPIAAEIEH	ATP1A1	276	P05023
VGQAGLELLTSGHPA	HSP90AA5P	6	Q58FG0
RLLHGDPGEEDGAEL	PDGFB	46	P01127
GGLHVIEGLPLLADS	PLXNA3	396	P51805
PGHVLDVEGEGLNLG	PLXNB3	1166	Q9ULL4
RGLEELGHGPLSLAG	PDZD4	591	Q76G19
IGLGVGEDHLLSLPA	PDE3A	176	Q14432
LLLSGVGPAHGSEDI	NOMO1	21	Q15155
LGVGTLPEHDSQDAG	AUTS2	251	Q8WXX7
NGSPGHLDLVEGSLL	F8	1531	P00451
DIEVLLGHGADPGIR	ANKRD65	251	E5RJM6
IECADHTLDSLGGGP	ASIC4	351	Q96FT7
AGLVDVDGHLVGEPE	KIF9	461	Q9HAQ2
VHLEEAGILRAGPGG	PCDHA5	806	Q9Y5H7
VDSVGAAALLGLGPH	HGFAC	321	Q04756
LTESGGDLVHLEGPL	IGHV8-51-1	21	P0DTE2
SVHLEEAGILRAGPG	PCDHAC2	876	Q9Y5I4
SVHLEEAGILRAGPG	PCDHA4	816	Q9UN74
VDLLGLHSEVGAGPA	GAK	881	O14976
LQLVDHVDGGDGILP	IL6ST	796	P40189
LLGGEELGPDGEFHA	KLHL15	331	Q96M94
GPTTGEGALDLSDVH	CEP43	141	O95684
EGLPLSAGKELVTGH	DCDC2B	181	A2VCK2
PLGECIIAGHESGEL	EIF3I	156	Q13347
ETEDGHSVDPGLAGL	BMP8A	221	Q7Z5Y6
EGTIDGLEPGLHGLH	CCS	116	O14618
STDRVLGAHILGPGA	DLD	446	P09622
FGTGLTPLHLSDDGE	DGCR2	406	P98153
GPEEEDAGGLHVLLT	INSRR	911	P14616
DAGGLHVLLTATPVG	INSRR	916	P14616
HLIGHEGPGSLLSEL	IDE	336	P14735
GDRLLSVDGIPLHGA	GRIP2	196	Q9C0E4
GLRPDGIVGHSLGEV	FASN	571	P49327
ETEDGHSVDPGLAGL	BMP8B	221	P34820
HQGPGLLLGATDEDL	CDH15	496	P55291
EDPALRHILDGGSGV	FAM171B	756	Q6P995
APGTAGTLHLVDLAG	KIFC2	616	Q96AC6
VHLEEAGILRAGPGG	PCDHA12	811	Q9UN75
LHGLVADSNLTLGPG	INSL3	76	P51460
VGTIGGTHIPLLAED	SLC16A6	396	O15403
GREDTGLLATTHGPE	PLIN4	1116	Q96Q06
GIGLEGEHILDLHSP	RIMBP2	256	O15034
EVELLGEHLPVGGFT	RNF38	311	Q9H0F5
SGDEGEELGLPLLST	WRAP53	491	Q9BUR4
HLKTSGLAGEPEGEL	MIA3	861	Q5JRA6
ADHSKSPEGLLGVLG	MED24	426	O75448
LSVEDALGLGEPEGS	SLC39A4	66	Q6P5W5
PGSAGGVLAALLDHV	SLC39A4	176	Q6P5W5
LLLEHQGSGPLECDG	SIPA1L2	1151	Q9P2F8
GLDLEAVRGGASHLP	INPPL1	191	O15357
PVDLSLGTLGEISGH	PHYHIP	291	Q92561
LSLHIEPEEGSLAGG	PKHD1	21	P08F94
GEISRGPDVHLTHGL	STARD9	3011	Q9P2P6
SVLFLHPDLGVGGAE	ALG2	16	Q9H553
HPDLGVGGAERLVLD	ALG2	21	Q9H553
GADLEHESEGGRTPL	ANKHD1	591	Q8IWZ3
GTLGGDFLSSLPLHE	PIAS3	501	Q9Y6X2
LILHSGNILDSGPGD	PITPNM1	431	O00562
LGDIQEPGHAEGILG	WFDC6	16	Q9BQY6
AETELVVPGHAEGLG	ZNF341	811	Q9BYN7
LLEGGPFSGLGEVIH	ZSWIM5	716	Q9P217
DGDSFLVLLEVPHGG	ZXDC	71	Q2QGD7
GGGHPLDLLSVTLAS	SPHK2	311	Q9NRA0
SLKHGPEVGLGDLSE	RYR3	4291	Q15413
GRLLDVLSGHEGPIS	PWP2	491	Q15269
EEVVGHTQGPLDGSL	TNS1	351	Q9HBL0
GSHIGGRLLPEATTE	SCN8A	656	Q9UQD0
AGGGVEPSLEHLLDI	TMUB2	126	Q71RG4
LGHILGREPTSSEQG	UBXN1	56	Q04323
GDGVGEHPTQALLDI	CAD	2046	P27708
LPGGLEGSSAVAHLL	ZNF469	3186	Q96JG9
SEDGSEDGLPEGIHL	ZNF217	441	O75362
PEVRLLHAGSGADTG	VWA8	41	A3KMH1
GHSTNLPDLVSGLGD	UBQLN3	436	Q9H347
HPLELVVRDSLGGGS	ZBTB8B	201	Q8NAP8
HEEGDGATDGPARLL	KMT2D	5036	O14686
GPTEEIRALHAAIGG	NAPSA	291	O96009
EHRGALTLDPGAGEA	GRIN2D	216	O15399