Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
DomainRap_GAP

SIPA1 SIPA1L2

3.50e-0410532PF02145
DomainRap_GAP_dom

SIPA1 SIPA1L2

4.27e-0411532IPR000331
DomainRAPGAP

SIPA1 SIPA1L2

4.27e-0411532PS50085
DomainCadherin_CS

FAT2 PCDHGB1 PCDHB8

3.66e-03109533IPR020894
DomainCADHERIN_1

FAT2 PCDHGB1 PCDHB8

4.05e-03113533PS00232
DomainCadherin

FAT2 PCDHGB1 PCDHB8

4.05e-03113533PF00028
DomainCADHERIN_2

FAT2 PCDHGB1 PCDHB8

4.16e-03114533PS50268
Domain-

FAT2 PCDHGB1 PCDHB8

4.16e-031145332.60.40.60
DomainCA

FAT2 PCDHGB1 PCDHB8

4.26e-03115533SM00112
DomainCadherin-like

FAT2 PCDHGB1 PCDHB8

4.36e-03116533IPR015919
DomainCadherin

FAT2 PCDHGB1 PCDHB8

4.58e-03118533IPR002126
DomainCadherin_C

PCDHGB1 PCDHB8

6.33e-0342532IPR032455
DomainCadherin_C_2

PCDHGB1 PCDHB8

6.33e-0342532PF16492
DomainC2

WWC3 SYT12 PLCG2

7.64e-03142533PS50004
Domain-

WWC3 SYT12 PLCG2

8.55e-031485332.60.40.150
Pubmed

BRCA2 interacts with the cytoskeletal linker protein plectin to form a complex controlling centrosome localization.

BRCA2 PLEC

2.46e-06255219709076
Pubmed

Functional proteomics mapping of a human signaling pathway.

TSKU ARHGAP5 PPP2R1A MYO6 ANAPC2 PDE4DIP PLCG2 PLEC

4.00e-0659155815231748
Pubmed

Role of binding of plectin to the integrin beta4 subunit in the assembly of hemidesmosomes.

COL17A1 PLEC

1.47e-05455214668477
Pubmed

N-Terminomics for the Identification of In Vitro Substrates and Cleavage Site Specificity of the SARS-CoV-2 Main Protease.

DHX16 SORBS2 NUP98 PLEC SIPA1 SRRM2

2.23e-0536055633111431
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

ARHGAP5 SORBS2 PTPRK CLIP2 MYO6 GUCY1B1 ASB3 PDE4DIP ABCC5 PLEC

2.94e-051285551035914814
Pubmed

Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.

FAM171A1 ARHGAP5 PPP2R1A PTPRK CLNS1A NAGLU NUP98 ZYG11B SRRM2

3.65e-05104955927880917
Pubmed

Junctional Epidermolysis Bullosa

COL17A1 PLEC

3.67e-05655220301304
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

DHX16 SORBS2 PDE4DIP ZYG11B SIPA1L2 SRRM2

4.42e-0540755612693553
Pubmed

The N terminus of the transmembrane protein BP180 interacts with the N-terminal domain of BP230, thereby mediating keratin cytoskeleton anchorage to the cell surface at the site of the hemidesmosome.

COL17A1 PLEC

5.13e-05755210637308
Pubmed

KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.

ARHGAP5 NLGN3 PPP2R1A SORBS2 CLIP2 MYO6 PDE4DIP PLEC SIPA1 SIPA1L2

7.27e-051431551037142655
Pubmed

Analysis of the interactions between BP180, BP230, plectin and the integrin alpha6beta4 important for hemidesmosome assembly.

COL17A1 PLEC

8.78e-05955212482924
Pubmed

Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.

FAM171A1 NLGN3 PPP2R1A SORBS2 CLIP2 PDE4DIP SIPA1 UNC79

1.29e-0496355828671696
Pubmed

A bead-based approach for large-scale identification of in vitro kinase substrates.

DHX16 CLNS1A NUP98 SRRM2

1.32e-0416355422113938
Pubmed

Interaction of the bullous pemphigoid antigen 1 (BP230) and desmoplakin with intermediate filaments is mediated by distinct sequences within their COOH terminus.

COL17A1 PLEC

1.34e-041155212802069
Pubmed

The tetraspan molecule CD151, a novel constituent of hemidesmosomes, associates with the integrin alpha6beta4 and may regulate the spatial organization of hemidesmosomes.

COL17A1 PLEC

1.34e-041155210811835
Pubmed

Current insights into the formation and breakdown of hemidesmosomes.

COL17A1 PLEC

1.34e-041155216757171
Pubmed

Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.

PPP2R1A MYO6 PDE4DIP NOL6 NAGLU NUP98 ZYG11B

1.80e-0475455733060197
Pubmed

Efficient capture of cardiogenesis-associated genes expressed in ES cells.

SORBS2 EML2

1.89e-041355217286962
Pubmed

Cell cycle and adhesion defects in mice carrying a targeted deletion of the integrin beta4 cytoplasmic domain.

COL17A1 PLEC

1.89e-04135529670011
Pubmed

A striking organization of a large family of human neural cadherin-like cell adhesion genes.

FAT2 PCDHGB1 PCDHB8

2.07e-047255310380929
Pubmed

Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members.

FAT2 PCDHGB1 PCDHB8

2.52e-047755310835267
Pubmed

Large exons encoding multiple ectodomains are a characteristic feature of protocadherin genes.

FAT2 PCDHGB1 PCDHB8

2.82e-048055310716726
Pubmed

Phosphoproteome analysis of the human mitotic spindle.

NOL6 NUP98 PLEC SRRM2

3.46e-0421055416565220
Pubmed

The TRIM9/TRIM67 neuronal interactome reveals novel activators of morphogenesis.

SORBS2 CLIP2 ZC3H12C SIPA1L2

3.99e-0421855433378226
Pubmed

Hrd1-mediated ACLY ubiquitination alleviate NAFLD in db/db mice.

MYO6 PLEC

4.13e-041955232888949
Pubmed

Suppression of ACE2 SUMOylation protects against SARS-CoV-2 infection through TOLLIP-mediated selective autophagy.

DHX16 TRPM4 PPP2R1A MYO6 NUP98 SRRM2

5.16e-0464155636057605
Pubmed

Use of expression data and the CGEMS genome-wide breast cancer association study to identify genes that may modify risk in BRCA1/2 mutation carriers.

BRCA2 PLCG2

5.56e-042255218095154
Pubmed

Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.

DHX16 PPP2R1A NOL6 NUP98 PLEC SRRM2

5.68e-0465355622586326
Pubmed

Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer.

SORBS2 FAM117B SRRM2

5.75e-0410255315778465
Pubmed

A meta-analysis of 87,040 individuals identifies 23 new susceptibility loci for prostate cancer.

NLGN3 MYO6

6.08e-042355225217961
Pubmed

Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells.

JARID2 PPP2R1A NOL6 NUP98 UNC79

8.72e-0446955527634302
Pubmed

Large-scale mapping of human protein-protein interactions by mass spectrometry.

PPP2R1A MYO6 ASB3 NUP98 EML2 SRRM2 UNC79 CCNY

8.80e-04128455817353931
Pubmed

PINK1 Content in Mitochondria is Regulated by ER-Associated Degradation.

DHX16 PPP2R1A MYO6 PLEC SRRM2

9.40e-0447755531300519
Pubmed

RNF138 inhibits late inflammatory gene transcription through degradation of SMARCC1 of the SWI/SNF complex.

PLEC SRRM2

9.70e-042955236800290
Pubmed

Defining the human deubiquitinating enzyme interaction landscape.

MYO6 CLNS1A NOL6 NUP98 ZYG11B PLEC SRRM2

9.99e-04100555719615732
Pubmed

The MYO6 interactome reveals adaptor complexes coordinating early endosome and cytoskeletal dynamics.

FAM171A1 MYO6 SRRM2

1.04e-0312555329467281
Pubmed

E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.

ARHGAP5 AFAP1L2 CLNS1A NAGLU FAM227B FAM186B

1.06e-0373655629676528
Pubmed

Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.

DHX16 SORBS2 COL17A1

1.16e-0313055312421765
Pubmed

Ligand-dependent differences in estrogen receptor beta-interacting proteins identified in lung adenocarcinoma cells corresponds to estrogenic responses.

MYO6 PLEC

1.18e-033255221951318
Pubmed

Cell Surface Proteomic Map of HIV Infection Reveals Antagonism of Amino Acid Metabolism by Vpu and Nef.

PTPRK PCDHGB1 CCR7

1.21e-0313255326439863
Pubmed

New interaction partners for Nek4.1 and Nek4.2 isoforms: from the DNA damage response to RNA splicing.

MYO6 CLNS1A NUP98 SRRM2 FAM186B

1.30e-0351355525798074
Pubmed

Large-scale characterization of HeLa cell nuclear phosphoproteins.

DHX16 SORBS2 NUP98 PLEC SRRM2 CCNY

1.37e-0377455615302935
Pubmed

Proteomic analysis of the NOS2 interactome in human airway epithelial cells.

PPP2R1A CLNS1A PLEC

1.38e-0313855323438482
Pubmed

ATPase-Modulated Stress Granules Contain a Diverse Proteome and Substructure.

PPP2R1A MYO6 NUP98 ZC3H7B

1.57e-0331555426777405
Pubmed

Control of APC/C-dependent ubiquitin chain elongation by reversible phosphorylation.

PPP2R1A ANAPC2

1.58e-033755226811472
GeneFamilyZinc fingers CCCH-type

ZC3H12C ZC3H7B

2.20e-033536273
GeneFamilyClustered protocadherins

PCDHGB1 PCDHB8

7.19e-036436220
ToppCellLPS-IL1RA-Endothelial-Endothelial-Activated_Alv_Cap|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

FAM171A1 MYO6 FAM117B ZC3H12C SIPA1L2

3.68e-06193545a3636c35ed25aabe2f1aba016c9fe125327bbfaf
ToppCell(02)_MMP9/10+-(1)_GFP|(02)_MMP9/10+ / shred by cell type by condition

JARID2 PPP2R1A COL17A1 PTPRK PLEC

4.27e-06199545448ba982be804007f991d469eca9d885b21ae499
ToppCellLPS_only-Endothelial-Endothelial-Alv_Cap|LPS_only / Treatment groups by lineage, cell group, cell type

FAM171A1 MYO6 GUCY1B1 ZC3H12C CCNY

4.37e-06200545432384faeade8e609154fab3d96c955a8ec868dd
ToppCellNS-control|NS / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

ARHGAP5 FAT2 SORBS2 PTPRK MYO6

4.37e-06200545ecbe89ff95d046155b984c8c150e0b9e7278f839
ToppCellLPS_only-Endothelial-Endothelial-Alv_Gen_Intermediate|LPS_only / Treatment groups by lineage, cell group, cell type

FAM171A1 MYO6 GUCY1B1 SIPA1L2 CCNY

4.37e-06200545b1fadb2b5e37e0f51e079d8409c2647eef68dc3b
ToppCellLPS_IL1RA-Endothelial-Endothelial-Activated_Alv_Cap|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

MYO6 GUCY1B1 ZC3H12C SIPA1L2 CCNY

4.37e-0620054579e51afb57ca38aacebd0298e5e727b55c0cfff9
ToppCellChildren_(3_yrs)-Endothelial-endothelial_cell_of_artery-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

FAM171A1 SORBS2 AFAP1L2 PLCG2

5.49e-051715441597459c971d6befa991d59dc66b41b6a522f797
ToppCellLPS-IL1RA-Endothelial-Endothelial-Alv_Cap|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

MYO6 FAM117B ZC3H12C SIPA1L2

6.70e-05180544544fb373a3346186ec60afe2cfcf141bb04a1eed
ToppCelldroplet-Limb_Muscle-MUSCLE-1m-Macroglial-unknown|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NLGN3 SORBS2 AFAP1L2 UNC79

7.00e-0518254482ca6d5ed48b4c487ce00b9309255abb8f20b61d
ToppCellfacs-Lung-24m-Hematologic-myeloid-non-classical_monocyte-nonclassical_monocyte_l14|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

COL17A1 PRRG3 PLCG2 SIPA1L2

7.15e-051835446e5b39c0170d62eb7fdd411dcfff51ed176573d0
ToppCellPBMC_fresh-frozen-Severe-critical_convalescent_d14-21-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD8_c01-LEF1|Severe-critical_convalescent_d14-21 / Compartment, severity and other cell annotations on 10x 3' data (130k)

PTPRK PRRG3 FAM117B CCR7

7.45e-05185544fcd95bc074e982fc7b8fd48d2e80038b9ea35ebb
ToppCellLPS-IL1RA+antiTNF-Endothelial-Endothelial-Activated_Alv_Cap|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

FAM171A1 WWC3 MYO6 ZC3H12C

7.77e-05187544f3397dbc23b6c2f24e2c1ba887d8f9aef3ee01a1
ToppCellLPS-IL1RA+antiTNF-Endothelial-Endothelial-Alv_Cap|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

FAM171A1 MYO6 ZC3H12C SIPA1L2

7.93e-0518854473f6ec915934154f435a376cb274b058ff7c5f35
ToppCellLPS_only-Endothelial-Endothelial-Activated_Alv_Cap|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

FAM171A1 PTPRK MYO6 ZC3H12C

8.43e-05191544a7b18bcf27c38ad2353c239ecb309c80f3ef3359
ToppCellLPS-antiTNF-Endothelial-Endothelial-Activated_Alv_Cap|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

FAM171A1 MYO6 FAM117B ZC3H12C

8.60e-05192544c618ede75dce3988c87a5b8f98d8e94e1dd66efd
ToppCellLPS-IL1RA-Endothelial-Endothelial|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

FAM171A1 MYO6 ZC3H12C SIPA1L2

8.95e-051945441d39d968730a7e85b6161c1c8a6bd38afe9bcad7
ToppCellLPS-IL1RA-Endothelial|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

FAM171A1 MYO6 ZC3H12C SIPA1L2

8.95e-0519454443f92b0533e26633dc94cce554045d641ef8fd76
ToppCell367C-Epithelial_cells-Epithelial-H_(AT1)|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

TSKU FAT2 COL17A1 SIPA1

9.32e-05196544e8db58e82300981f981402618a1befb91f6690fd
ToppCell367C-Epithelial_cells-Epithelial-H_(AT1)-|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

TSKU FAT2 COL17A1 SIPA1

9.32e-051965442cf42b702ea15adfa6bbd86a3c9613271863f86c
ToppCellLPS_IL1RA-Endothelial-Endothelial-Alv_Cap|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

MYO6 FAM117B PLEC CCNY

1.01e-042005447034f57e282982c19c13ee8ab78eabaffa069e30
ToppCellLPS_IL1RA-Endothelial-Endothelial-Alv_Gen_Intermediate|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

FAM171A1 MYO6 PLEC CCNY

1.01e-04200544b70b7adb7c187e6253c7f0bb4c1f09c85ef7142c
ToppCellcontrol|World / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

ARHGAP5 FAT2 SORBS2 MYO6

1.01e-0420054497f36d2c197e03d93a1fc59949d77ae90f6e6a9a
ToppCellControl_saline-Endothelial|Control_saline / Treatment groups by lineage, cell group, cell type

FAM171A1 MYO6 PLEC SIPA1L2

1.01e-042005443372c488a39fe812fa94e4f0564594186fea3db5
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW09-Neuronal-Interneuron|GW09 / Sample Type, Dataset, Time_group, and Cell type.

AFAP1L2 PRRG3 TMPRSS7 UNC79

1.01e-04200544a6500d0d2e8bcac92381ab771dbdee66b0e1d48e
ToppCellLPS_IL1RA_TNF-Endothelial-Endothelial-Activated_Alv_Cap|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

WWC3 MYO6 GUCY1B1 CCNY

1.01e-0420054489821a264e872ed53e08e9d3609d5cc5c314503e
ToppCellControl_saline-Endothelial-Endothelial|Control_saline / Treatment groups by lineage, cell group, cell type

FAM171A1 MYO6 PLEC SIPA1L2

1.01e-04200544e77eba6172cabf85b8028638ed35299f2f079cd8
Diseasemelanoma

BRCA2 PTPRK CLNS1A PCDHB8 SIPA1

6.90e-05248515C0025202
DiseaseHMG CoA reductase inhibitor use measurement

BRCA2 GUCY1B1 FAM117B PLEC

3.22e-04189514EFO_0009932
Diseaselymphocyte count

JARID2 SYT12 PCDHGB1 ASB3 OSER1 ABCC5 CCR7 PLEC ZC3H7B

8.20e-041464519EFO_0004587
Diseaseuterine fibroid measurement

SORBS2 PTPRK

1.15e-0329512EFO_0009410

Protein segments in the cluster

PeptideGeneStartEntry
RTRSELLPFLTDTIY

PPP2R1A

46

P30153
SLLSLDYAELSSRIL

COL17A1

1121

Q9UMD9
RAYTLPISKEESRLS

FAM227B

351

Q96M60
GLLESRLDPYLRSLE

ANAPC2

116

Q9UJX6
SLEPVERSLETSSYL

AFAP1L2

346

Q8N4X5
IPELLYSDLQRSSSE

CCR7

191

P32248
RYSLIDRSSAPELLR

CLIP2

971

Q9UDT6
SRLESYRPDTDLSRE

CCNY

21

Q8ND76
LSEESELRLPHYLRS

FAM186B

676

Q8IYM0
LLREFLSEPDLASYS

DHX16

501

O60231
ATSPAFRYDLLDLTR

NAGLU

551

P54802
EPRSITADPLDYRLS

NUP98

1511

P52948
RRALRLPENTSYSDL

FAM171A1

151

Q5VUB5
LTLSYSRRGDLEISL

PCSK4

496

Q6UW60
PDSRDTSRLEYLILS

FAT2

2406

Q9NYQ8
SILASDLEPRELLSY

PCDHGB1

486

Q9Y5G3
YETLRERSSLLPRLD

NOL6

711

Q9H6R4
DDLTRRGLYLSDIPL

GUCY1B1

331

Q02153
LRSESSPEAYIRCLR

PLCG2

336

P16885
LLTLYRDQDRESPST

PLEKHG6

526

Q3KR16
SDRSIYILDDPLSAL

ABCC5

701

O15440
DYTLTLRRSPDDIPL

NLGN3

791

Q9NZ94
SERLRSDSYISQLPL

ASB3

476

Q9Y575
LALPLYRSTRRLSEE

C17orf99

231

Q6UX52
LEYPTISLHALSRDR

CLNS1A

56

P54105
TAPTSSEDYLRLKRR

BRCA2

3371

P51587
RRTSSLDTLAAPYLA

FAM117B

216

Q6P1L5
DIPLDRLTISYCRSS

MRPL58

71

Q14197
TDRLGERDPRSLTLY

MAN2C1

131

Q9NTJ4
DELAPTYSLDTRSEL

EML2

36

O95834
TYSLDTRSELPSCRL

EML2

41

O95834
PRLTLYSEAELSSLV

ERVFC1

361

P60507
ATAESSRLLDVPRYL

PTPRK

836

Q15262
LSYDSLSPEEHRRLE

JARID2

706

Q92833
FYTLLTETPLDRESR

PCDHB8

401

Q9UN66
SLVYLRPRSSTSEDE

OR10Q1

261

Q8NGQ4
EILLSLSYLPTAERL

SYT12

286

Q8IV01
PIDSLRDSRSLSYSP

SRRM2

2681

Q9UQ35
PDSLFRSLLERYLTA

TDRD6

201

O60522
NLSPRRSLYRTLSDE

SIPA1L2

1476

Q9P2F8
FSELYTLSLQEPSRR

SIPA1

771

Q96FS4
LPTPSDRSRYRLDLE

ARHGAP5

1001

Q13017
LAPERRSTLEDYSQS

OSER1

226

Q9NX31
ERPASLYQSSIDRSL

SORBS2

226

O94875
LTLSLEDPYERCFSR

ZYG11B

146

Q9C0D3
TDSLTIYDSLLPIRS

TMPRSS7

301

Q7RTY8
PSTDERLSYTQLLRR

PLEC

3986

Q15149
SPERRFSLDTDYRIS

ZC3H12C

606

Q9C0D7
PTAFSRLRYLESLDL

TSKU

101

Q8WUA8
LESTLYLPELSLSRL

PRRG3

171

Q9BZD7
LRLSDRTDPAAVYSL

TRPM4

91

Q8TD43
RLYRSDSDSSTLPRK

WWC3

921

Q9ULE0
RSLLYSVLRDAPSER

UNC79

96

Q9P2D8
LLPYSETRLDALDSF

ZC3H7B

351

Q9UGR2
DLALRRSLDSYPVSK

MYO6

1031

Q9UM54
SDYSSSLERPRKLRA

PDE4DIP

1386

Q5VU43