Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	ribonucleoside triphosphate phosphatase activity	ABCA3 GBP7 DNAH2 EIF2S3B GTPBP10 DHX15 EIF2S3 MLH1 TOR1B ATP12A ATP2A1 ATP2A2 DHX29 DNAH9 DNAH11	7.03e-05	775	121	15	GO:0017111
GeneOntologyMolecularFunction	ATP hydrolysis activity	ABCA3 DNAH2 DHX15 MLH1 TOR1B ATP12A ATP2A1 ATP2A2 DHX29 DNAH9 DNAH11	7.77e-05	441	121	11	GO:0016887
GeneOntologyMolecularFunction	minus-end-directed microtubule motor activity	DNAH2 DNAH9 DNAH11	1.66e-04	18	121	3	GO:0008569
GeneOntologyMolecularFunction	pyrophosphatase activity	ABCA3 GBP7 DNAH2 EIF2S3B GTPBP10 DHX15 EIF2S3 MLH1 TOR1B ATP12A ATP2A1 ATP2A2 DHX29 DNAH9 DNAH11	1.69e-04	839	121	15	GO:0016462
GeneOntologyMolecularFunction	hydrolase activity, acting on acid anhydrides	ABCA3 GBP7 DNAH2 EIF2S3B GTPBP10 DHX15 EIF2S3 MLH1 TOR1B ATP12A ATP2A1 ATP2A2 DHX29 DNAH9 DNAH11	1.71e-04	840	121	15	GO:0016817
GeneOntologyMolecularFunction	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	ABCA3 GBP7 DNAH2 EIF2S3B GTPBP10 DHX15 EIF2S3 MLH1 TOR1B ATP12A ATP2A1 ATP2A2 DHX29 DNAH9 DNAH11	1.71e-04	840	121	15	GO:0016818
GeneOntologyMolecularFunction	tRNA binding	EIF2S3B YARS2 SEPSECS AARS2 EIF2S3	1.87e-04	87	121	5	GO:0000049
GeneOntologyMolecularFunction	alanine-tRNA ligase activity	AARSD1 AARS2	2.17e-04	4	121	2	GO:0004813
GeneOntologyMolecularFunction	glycerophosphodiester phosphodiesterase activity	GDE1 GPCPD1	5.38e-04	6	121	2	GO:0008889
GeneOntologyMolecularFunction	dynein light intermediate chain binding	DNAH2 DNAH9 DNAH11	6.37e-04	28	121	3	GO:0051959
GeneOntologyMolecularFunction	transporter activity	GABRP ABCA3 SLC37A3 GRIK1 ATG2A PKD1L3 CHRNE SLC52A3 SLC6A4 CNNM3 SLCO1C1 KCND2 SLC22A3 LRRC8A SV2C ATP12A ATP2A1 ATP2A2	7.54e-04	1289	121	18	GO:0005215
GeneOntologyMolecularFunction	transmembrane transporter activity	GABRP ABCA3 SLC37A3 GRIK1 PKD1L3 CHRNE SLC52A3 SLC6A4 CNNM3 SLCO1C1 KCND2 SLC22A3 LRRC8A SV2C ATP12A ATP2A1 ATP2A2	7.58e-04	1180	121	17	GO:0022857
GeneOntologyMolecularFunction	XMP 5'-nucleosidase activity	NT5C3A NT5C3B	9.96e-04	8	121	2	GO:0106411
GeneOntologyMolecularFunction	hydrolase activity, acting on ester bonds	DAGLB EPHX2 MBLAC2 NT5C3A PON1 NT5C3B PTBP1 AARSD1 GDE1 AARS2 PTPRJ XRN1 GPCPD1	1.23e-03	807	121	13	GO:0016788
GeneOntologyMolecularFunction	ATP-dependent activity	ABCA3 DNAH2 DHX15 MLH1 TOR1B ATP12A ATP2A1 ATP2A2 DHX29 DNAH9 DNAH11	1.28e-03	614	121	11	GO:0140657
GeneOntologyMolecularFunction	P-type transmembrane transporter activity	ATP12A ATP2A1 ATP2A2	1.34e-03	36	121	3	GO:0140358
GeneOntologyMolecularFunction	P-type ion transporter activity	ATP12A ATP2A1 ATP2A2	1.34e-03	36	121	3	GO:0015662
GeneOntologyMolecularFunction	dynein intermediate chain binding	DNAH2 DNAH9 DNAH11	1.45e-03	37	121	3	GO:0045505
Domain	-	COL6A2 SEC24D INTS14 COCH HMCN1 ITIH6	8.05e-06	74	120	6	3.40.50.410
Domain	HAD-like_dom	EPHX2 NT5C3A NT5C3B ATP12A ATP2A1 ATP2A2	1.18e-05	79	120	6	IPR023214
Domain	DHC_N1	DNAH2 DNAH9 DNAH11	1.41e-05	8	120	3	PF08385
Domain	Dynein_heavy_dom-1	DNAH2 DNAH9 DNAH11	1.41e-05	8	120	3	IPR013594
Domain	UMPH-1	NT5C3A NT5C3B	4.09e-05	2	120	2	PF05822
Domain	Pyrimidine_nucleotidase_eu	NT5C3A NT5C3B	4.09e-05	2	120	2	IPR006434
Domain	VWF_A	COL6A2 SEC24D INTS14 COCH HMCN1 ITIH6	4.27e-05	99	120	6	IPR002035
Domain	Dynein_heavy_chain_D4_dom	DNAH2 DNAH9 DNAH11	8.94e-05	14	120	3	IPR024317
Domain	Dynein_HC_stalk	DNAH2 DNAH9 DNAH11	8.94e-05	14	120	3	IPR024743
Domain	Dynein_heavy_dom-2	DNAH2 DNAH9 DNAH11	8.94e-05	14	120	3	IPR013602
Domain	DHC_N2	DNAH2 DNAH9 DNAH11	8.94e-05	14	120	3	PF08393
Domain	ATPase_dyneun-rel_AAA	DNAH2 DNAH9 DNAH11	8.94e-05	14	120	3	IPR011704
Domain	MT	DNAH2 DNAH9 DNAH11	8.94e-05	14	120	3	PF12777
Domain	AAA_8	DNAH2 DNAH9 DNAH11	8.94e-05	14	120	3	PF12780
Domain	AAA_5	DNAH2 DNAH9 DNAH11	8.94e-05	14	120	3	PF07728
Domain	DHC_fam	DNAH2 DNAH9 DNAH11	1.11e-04	15	120	3	IPR026983
Domain	Dynein_heavy	DNAH2 DNAH9 DNAH11	1.11e-04	15	120	3	PF03028
Domain	Dynein_heavy_dom	DNAH2 DNAH9 DNAH11	1.11e-04	15	120	3	IPR004273
Domain	Ala-tRNA-lgiase_IIc	AARSD1 AARS2	1.22e-04	3	120	2	IPR002318
Domain	P-type_ATPase_IIA	ATP2A1 ATP2A2	1.22e-04	3	120	2	IPR005782
Domain	ATPase_P-typ_TM_dom	ATP12A ATP2A1 ATP2A2	1.36e-04	16	120	3	IPR023298
Domain	-	ATP12A ATP2A1 ATP2A2	1.36e-04	16	120	3	1.20.1110.10
Domain	ATPase_P-typ_cation-transptr_C	ATP12A ATP2A1 ATP2A2	1.65e-04	17	120	3	IPR006068
Domain	Cation_ATPase_C	ATP12A ATP2A1 ATP2A2	1.65e-04	17	120	3	PF00689
Domain	VWFA	COL6A2 INTS14 COCH HMCN1 ITIH6	1.85e-04	82	120	5	PS50234
Domain	Cation_ATPase_N	ATP12A ATP2A1 ATP2A2	1.97e-04	18	120	3	PF00690
Domain	Cation_ATPase_N	ATP12A ATP2A1 ATP2A2	1.97e-04	18	120	3	SM00831
Domain	VWA	COL6A2 INTS14 COCH HMCN1 ITIH6	2.07e-04	84	120	5	SM00327
Domain	ATPase_P-typ_cation-transptr_N	ATP12A ATP2A1 ATP2A2	2.32e-04	19	120	3	IPR004014
Domain	Ala-tRNA-synth_IIc_core	AARSD1 AARS2	2.44e-04	4	120	2	IPR018165
Domain	Ala-tRNA-synth_IIc_N	AARSD1 AARS2	2.44e-04	4	120	2	IPR018164
Domain	tRNA-synt_2c	AARSD1 AARS2	2.44e-04	4	120	2	PF01411
Domain	AA_TRNA_LIGASE_II_ALA	AARSD1 AARS2	2.44e-04	4	120	2	PS50860
Domain	AAA	ABCA3 DNAH2 DHX15 TOR1B DNAH9 DNAH11	3.36e-04	144	120	6	SM00382
Domain	AAA+_ATPase	ABCA3 DNAH2 DHX15 TOR1B DNAH9 DNAH11	3.36e-04	144	120	6	IPR003593
Domain	HnRNP-L/PTB	PTBP2 PTBP1	4.04e-04	5	120	2	IPR006536
Domain	GP_PDE_dom	GDE1 GPCPD1	8.42e-04	7	120	2	IPR030395
Domain	tRNA_SAD	AARSD1 AARS2	8.42e-04	7	120	2	IPR012947
Domain	GlyceroP-diester-Pdiesterase	GDE1 GPCPD1	8.42e-04	7	120	2	IPR004129
Domain	GDPD	GDE1 GPCPD1	8.42e-04	7	120	2	PF03009
Domain	tRNA_SAD	AARSD1 AARS2	8.42e-04	7	120	2	SM00863
Domain	GP_PDE	GDE1 GPCPD1	8.42e-04	7	120	2	PS51704
Domain	tRNA_SAD	AARSD1 AARS2	8.42e-04	7	120	2	PF07973
Domain	Thr/Ala-tRNA-synth_IIc_edit	AARSD1 AARS2	1.12e-03	8	120	2	IPR018163
Domain	Epox_hydrolase-like	EPHX2 MEST	1.12e-03	8	120	2	IPR000639
Domain	-	ATP12A ATP2A1 ATP2A2	1.12e-03	32	120	3	3.40.1110.10
Domain	-	ATP12A ATP2A1 ATP2A2	1.12e-03	32	120	3	2.70.150.10
Domain	Calx_beta	ADGRV1 FREM1	1.43e-03	9	120	2	IPR003644
Domain	Calx-beta	ADGRV1 FREM1	1.43e-03	9	120	2	PF03160
Domain	ATPase_P-typ_cyto_domN	ATP12A ATP2A1 ATP2A2	1.46e-03	35	120	3	IPR023299
Domain	ATPase_P-typ_P_site	ATP12A ATP2A1 ATP2A2	1.58e-03	36	120	3	IPR018303
Domain	P_typ_ATPase	ATP12A ATP2A1 ATP2A2	1.58e-03	36	120	3	IPR001757
Domain	ATPASE_E1_E2	ATP12A ATP2A1 ATP2A2	1.58e-03	36	120	3	PS00154
Domain	ATPase_P-typ_transduc_dom_A	ATP12A ATP2A1 ATP2A2	1.71e-03	37	120	3	IPR008250
Domain	E1-E2_ATPase	ATP12A ATP2A1 ATP2A2	1.71e-03	37	120	3	PF00122
Domain	Hydrolase_3	ATP2A1 ATP2A2	1.78e-03	10	120	2	PF08282
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_SOD1_TO_RETROGRADE_AXONAL_TRANSPORT	DNAH2 ACTR1A DNAH9 DNAH11	3.02e-05	27	95	4	M47755
Pathway	BIOCARTA_EIF2_PATHWAY	EIF2S3B GSK3B EIF2S3	3.44e-05	10	95	3	MM1469
Pubmed	Cullin 1 (CUL1) Promotes Primary Ciliogenesis through the Induction of Ubiquitin-Proteasome-Dependent Dvl2 Degradation.	ADGRV1 FREM1 HMCN1 BEND7 NUP188 ARHGAP19 DNAH11	1.37e-06	152	125	7	34299191
Pubmed	Mutations in DNAH17, Encoding a Sperm-Specific Axonemal Outer Dynein Arm Heavy Chain, Cause Isolated Male Infertility Due to Asthenozoospermia.	DNAH2 DNAH9 DNAH11	1.57e-06	7	125	3	31178125
Pubmed	HSF1 phosphorylation establishes an active chromatin state via the TRRAP-TIP60 complex and promotes tumorigenesis.	FAT4 NUP210L CAMK4 DNAH2 PFAS EIF2S3B PTBP1 SORCS1 DHX15 EIF2S3 SV2C PLOD1 VSIG10L2	3.48e-06	754	125	13	35906200
Pubmed	Targeted disruption of the ATP2A1 gene encoding the sarco(endo)plasmic reticulum Ca2+ ATPase isoform 1 (SERCA1) impairs diaphragm function and is lethal in neonatal mice.	ATP2A1 ATP2A2	1.28e-05	2	125	2	12556521
Pubmed	Chronic mild stress alters synaptic plasticity in the nucleus accumbens through GSK3β-dependent modulation of Kv4.2 channels.	GSK3B KCND2	1.28e-05	2	125	2	32209671
Pubmed	Atypical fast SERCA1a protein expression in slow myofibers and differential S-nitrosylation prevented by exercise during long term bed rest.	ATP2A1 ATP2A2	1.28e-05	2	125	2	19644701
Pubmed	Sarco(endo)plasmic reticulum Ca2+ ATPases (SERCA1 and -2) in human extraocular muscles.	ATP2A1 ATP2A2	1.28e-05	2	125	2	14638697
Pubmed	Organic cation transporter capable of transporting serotonin is up-regulated in serotonin transporter-deficient mice.	SLC6A4 SLC22A3	1.28e-05	2	125	2	12584728
Pubmed	Dual-vector gene therapy restores cochlear amplification and auditory sensitivity in a mouse model of DFNB16 hearing loss.	STRC STRCP1	1.28e-05	2	125	2	34910522
Pubmed	Streamlined platform for short hairpin RNA interference and transgenesis in cultured mammalian cells.	PTBP2 PTBP1	1.28e-05	2	125	2	21768390
Pubmed	GSK3β Modulates Timing-Dependent Long-Term Depression Through Direct Phosphorylation of Kv4.2 Channels.	GSK3B KCND2	1.28e-05	2	125	2	29790931
Pubmed	Effect of chronic obstructive pulmonary disease on calcium pump ATPase expression in human diaphragm.	ATP2A1 ATP2A2	1.28e-05	2	125	2	15718407
Pubmed	SERCA1 truncated proteins unable to pump calcium reduce the endoplasmic reticulum calcium concentration and induce apoptosis.	ATP2A1 ATP2A2	1.28e-05	2	125	2	11402072
Pubmed	The Emerging Role of the RBM20 and PTBP1 Ribonucleoproteins in Heart Development and Cardiovascular Diseases.	PTBP1 RBM20	1.28e-05	2	125	2	32276354
Pubmed	Alternative splicing of brain-specific PTB defines a tissue-specific isoform pattern that predicts distinct functional roles.	PTBP2 PTBP1	1.28e-05	2	125	2	12213192
Pubmed	PTBP1 and PTBP2 Repress Nonconserved Cryptic Exons.	PTBP2 PTBP1	1.28e-05	2	125	2	27681424
Pubmed	Glycogen synthase kinase-3β is involved in C-reactive protein-induced endothelial cell activation.	GSK3B CRP	1.28e-05	2	125	2	24228880
Pubmed	Mutations in a new gene encoding a protein of the hair bundle cause non-syndromic deafness at the DFNB16 locus.	STRC STRCP1	1.28e-05	2	125	2	11687802
Pubmed	Organic cation transporter 3: Keeping the brake on extracellular serotonin in serotonin-transporter-deficient mice.	SLC6A4 SLC22A3	1.28e-05	2	125	2	19033200
Pubmed	Sarco(endo)plasmic reticulum Ca2+ ATPase isoforms and their role in muscle physiology and pathology.	ATP2A1 ATP2A2	1.28e-05	2	125	2	10603953
Pubmed	Characterizing SERCA Function in Murine Skeletal Muscles after 35-37 Days of Spaceflight.	ATP2A1 ATP2A2	1.28e-05	2	125	2	34769190
Pubmed	Training induced decrease in oxygen cost of cycling is accompanied by down-regulation of SERCA expression in human vastus lateralis muscle.	ATP2A1 ATP2A2	1.28e-05	2	125	2	18953100
Pubmed	SERCA overexpression reduces hydroxyl radical injury in murine myocardium.	ATP2A1 ATP2A2	1.28e-05	2	125	2	16798816
Pubmed	A post-transcriptional regulatory switch in polypyrimidine tract-binding proteins reprograms alternative splicing in developing neurons.	PTBP2 PTBP1	1.28e-05	2	125	2	17606642
Pubmed	Repeated swim impairs serotonin clearance via a corticosterone-sensitive mechanism: organic cation transporter 3, the smoking gun.	SLC6A4 SLC22A3	1.28e-05	2	125	2	21068324
Pubmed	Dissection of the functional differences between sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA) 1 and 2 isoforms and characterization of Darier disease (SERCA2) mutants by steady-state and transient kinetic analyses.	ATP2A1 ATP2A2	1.28e-05	2	125	2	12975374
Pubmed	Sexually dimorphic expression of the X-linked gene Eif2s3x mRNA but not protein in mouse brain.	EIF2S3B EIF2S3	1.28e-05	2	125	2	16325480
Pubmed	Breakdown of the reciprocal stabilization of QBRICK/Frem1, Fras1, and Frem2 at the basement membrane provokes Fraser syndrome-like defects.	COL6A2 FREM1 GRIP1	2.45e-05	16	125	3	16880404
Pubmed	ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.	FAT4 FKBP9 EXTL3 GDE1 DHX15 MEST CNNM3 COCH PTPRJ SLC22A3 LRRC8A TOR1B PLOD1 ATP2A2 PCDH7	2.83e-05	1201	125	15	35696571
Pubmed	SLFN11 promotes CDT1 degradation by CUL4 in response to replicative DNA damage, while its absence leads to synthetic lethality with ATR/CHK1 inhibitors.	HECTD4 PTBP1 DHX15 HINFP RBM19 HERC2 DHX29	3.54e-05	250	125	7	33536335
Pubmed	RNA-binding proteins RBM20 and PTBP1 regulate the alternative splicing of FHOD3.	PTBP1 RBM20	3.84e-05	3	125	2	30468920
Pubmed	The role of phospholamban and GSK3 in regulating rodent cardiac SERCA function.	GSK3B ATP2A2	3.84e-05	3	125	2	32755452
Pubmed	Cochlear outer hair cell horizontal top connectors mediate mature stereocilia bundle mechanics.	STRC STRCP1	3.84e-05	3	125	2	30801007
Pubmed	Serotonin homeostasis in the materno-foetal interface at term: Role of transporters (SERT/SLC6A4 and OCT3/SLC22A3) and monoamine oxidase A (MAO-A) in uptake and degradation of serotonin by human and rat term placenta.	SLC6A4 SLC22A3	3.84e-05	3	125	2	32311818
Pubmed	Calpain 3 deficiency affects SERCA expression and function in the skeletal muscle.	ATP2A1 ATP2A2	3.84e-05	3	125	2	27055500
Pubmed	Sarcoplasmic reticulum Ca2+ ATPase pump is a major regulator of glucose transport in the healthy and diabetic heart.	ATP2A1 ATP2A2	3.84e-05	3	125	2	25615793
Pubmed	The Apaf-1 internal ribosome entry segment attains the correct structural conformation for function via interactions with PTB and unr.	PTBP2 PTBP1	3.84e-05	3	125	2	12667457
Pubmed	Altered mRNA splicing of the skeletal muscle ryanodine receptor and sarcoplasmic/endoplasmic reticulum Ca2+-ATPase in myotonic dystrophy type 1.	ATP2A1 ATP2A2	3.84e-05	3	125	2	15972723
Pubmed	Relevance of brain natriuretic peptide in preload-dependent regulation of cardiac sarcoplasmic reticulum Ca2+ ATPase expression.	ATP2A1 ATP2A2	3.84e-05	3	125	2	16754798
Pubmed	BVVL/ FL: features caused by SLC52A3 mutations; WDFY4 and TNFSF13B may be novel causative genes.	WDFY4 SLC52A3	3.84e-05	3	125	2	33189404
Pubmed	MRG15 is required for pre-mRNA splicing and spermatogenesis.	PTBP2 PTBP1	3.84e-05	3	125	2	27573846
Pubmed	Molecular basis of titin exon exclusion by RBM20 and the novel titin splice regulator PTB4.	PTBP1 RBM20	3.84e-05	3	125	2	29518215
Pubmed	Expression of human nPTB is limited by extreme suboptimal codon content.	PTBP2 PTBP1	3.84e-05	3	125	2	18335065
Pubmed	Phospholamban domain IB forms an interaction site with the loop between transmembrane helices M6 and M7 of sarco(endo)plasmic reticulum Ca2+ ATPases.	ATP2A1 ATP2A2	3.84e-05	3	125	2	11526231
Pubmed	The effects of the phenylalanine 256 to valine mutation on the sensitivity of sarcoplasmic/endoplasmic reticulum Ca2+ ATPase (SERCA) Ca2+ pump isoforms 1, 2, and 3 to thapsigargin and other inhibitors.	ATP2A1 ATP2A2	3.84e-05	3	125	2	16410239
Pubmed	Identification of Drosophila and human 7-methyl GMP-specific nucleotidases.	NT5C3A NT5C3B	3.84e-05	3	125	2	23223233
Pubmed	Control of embryonic stem cell self-renewal and differentiation via coordinated alternative splicing and translation of YY2.	PTBP2 PTBP1	3.84e-05	3	125	2	27791185
Pubmed	Polypyrimidine tract binding protein 2 stabilizes phosphoglycerate kinase 2 mRNA in murine male germ cells by binding to its 3'UTR.	PTBP2 PTBP1	3.84e-05	3	125	2	17329592
Pubmed	Coordinate regulation of SR Ca(2+)-ATPase and phospholamban expression in developing murine heart.	ATP2A1 ATP2A2	3.84e-05	3	125	2	9038922
Pubmed	PTBP1 and PTBP2 impaired autoregulation of SRSF3 in cancer cells.	PTBP2 PTBP1	3.84e-05	3	125	2	26416554
Pubmed	Specific effects of endurance and sprint training on protein expression of calsequestrin and SERCA in mouse skeletal muscle.	ATP2A1 ATP2A2	3.84e-05	3	125	2	22466636
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	SLC37A3 HECTD4 PFAS EXTL3 ATG2A SLC52A3 ACTR1A EHBP1L1 RBM19 PDZD8 NUP188 HERC2 DNMBP D2HGDH	4.56e-05	1105	125	14	35748872
Pubmed	Overexpression of TEAD-1 in transgenic mouse striated muscles produces a slower skeletal muscle contractile phenotype.	GSK3B ATP2A1 ATP2A2	4.94e-05	20	125	3	18978355
Pubmed	TEAD-1 overexpression in the mouse heart promotes an age-dependent heart dysfunction.	GSK3B NFATC4 ATP2A2	5.75e-05	21	125	3	20194497
Pubmed	Quantitative targeted absolute proteomic analysis of transporters, receptors and junction proteins for validation of human cerebral microvascular endothelial cell line hCMEC/D3 as a human blood-brain barrier model.	ABCA3 SLCO1C1 SLC22A3	5.75e-05	21	125	3	23137377
Pubmed	The protein phosphatase-1/inhibitor-2 complex differentially regulates GSK3 dephosphorylation and increases sarcoplasmic/endoplasmic reticulum calcium ATPase 2 levels.	GSK3B ATP2A2	7.65e-05	4	125	2	16987514
Pubmed	Stereocilin-deficient mice reveal the origin of cochlear waveform distortions.	STRC STRCP1	7.65e-05	4	125	2	18849963
Pubmed	GSKIP- and GSK3-mediated anchoring strengthens cAMP/PKA/Drp1 axis signaling in the regulation of mitochondrial elongation.	GSK3B PRKAR2B	7.65e-05	4	125	2	25920809
Pubmed	Comparative expression analysis of the genes encoding polypyrimidine tract binding protein (PTB) and its neural homologue (brPTB) in prenatal and postnatal mouse brain.	PTBP2 PTBP1	7.65e-05	4	125	2	11231079
Pubmed	Injury induces early activation of T-cell receptor signaling pathways in CD4+ regulatory T cells.	GSK3B NFATC4	7.65e-05	4	125	2	20720513
Pubmed	Association of paraoxonase (PON)1 activity, glutathione S-transferase GST T1/M1 and STin.2 polymorphisms with comorbidity of tobacco use disorder and mood disorders.	PON1 SLC6A4	7.65e-05	4	125	2	25445355
Pubmed	Insulin receptor substrate proteins create a link between the tyrosine phosphorylation cascade and the Ca2+-ATPases in muscle and heart.	ATP2A1 ATP2A2	7.65e-05	4	125	2	9295312
Pubmed	Expression of sarco (endo) plasmic reticulum calcium ATPase (SERCA) system in normal mouse cardiovascular tissues, heart failure and atherosclerosis.	ATP2A1 ATP2A2	7.65e-05	4	125	2	25110346
Pubmed	Suppression of MEHMO Syndrome Mutation in eIF2 by Small Molecule ISRIB.	EIF2S3B EIF2S3	7.65e-05	4	125	2	31836389
Pubmed	[Research on associations between selected polymorphisms of genes DRD2, 5HTT, GRIK3, ADH4 and alcohol dependence syndrome].	ADH4 SLC6A4	7.65e-05	4	125	2	22232963
Pubmed	SON drives oncogenic RNA splicing in glioblastoma by regulating PTBP1/PTBP2 switching and RBFOX2 activity.	PTBP2 PTBP1	7.65e-05	4	125	2	34548489
Pubmed	Chronic phospholamban-sarcoplasmic reticulum calcium ATPase interaction is the critical calcium cycling defect in dilated cardiomyopathy.	ATP2A1 ATP2A2	7.65e-05	4	125	2	10555147
Pubmed	Clustering of Genetic Anomalies of Cilia Outer Dynein Arm and Central Apparatus in Patients with Transposition of the Great Arteries.	DNAH9 DNAH11	7.65e-05	4	125	2	36140829
Pubmed	Sarcolipin inhibits polymerization of phospholamban to induce superinhibition of sarco(endo)plasmic reticulum Ca2+-ATPases (SERCAs).	ATP2A1 ATP2A2	7.65e-05	4	125	2	12032137
Pubmed	Ischemic Stroke and Six Genetic Variants in CRP, EPHX2, FGA, and NOTCH3 Genes: A Meta-Analysis.	EPHX2 CRP	7.65e-05	4	125	2	27266621
Pubmed	High plasma C-reactive protein (CRP) is related to low paraoxonase-I (PON-I) activity independently of high leptin and low adiponectin in type 2 diabetes mellitus.	PON1 CRP	7.65e-05	4	125	2	18505467
Pubmed	The nongastric H+-K+-ATPases: molecular and functional properties.	ATP2A1 ATP2A2	7.65e-05	4	125	2	10362770
Pubmed	Glycogen synthase kinase 3beta interaction protein functions as an A-kinase anchoring protein.	GSK3B PRKAR2B	7.65e-05	4	125	2	20007971
Pubmed	Neuritin Up-regulates Kv4.2 α-Subunit of Potassium Channel Expression and Affects Neuronal Excitability by Regulating the Calcium-Calcineurin-NFATc4 Signaling Pathway.	KCND2 NFATC4	7.65e-05	4	125	2	27307045
Pubmed	Lack of nitric oxide synthase depresses ion transporting enzyme function in cardiac muscle.	ATP2A1 ATP2A2	7.65e-05	4	125	2	12074580
Pubmed	SERCA1a can functionally substitute for SERCA2a in the heart.	ATP2A1 ATP2A2	7.65e-05	4	125	2	9887021
Pubmed	Murine SEC24D can substitute functionally for SEC24C during embryonic development.	SLC6A4 SEC24D	7.65e-05	4	125	2	34702932
Pubmed	Fibril treatment changes protein interactions of tau and α-synuclein in human neurons.	PTBP1 AARSD1 GSK3B GRIP1 MEST EIF2S3 XRN1 PRKAR2B DHX29	8.30e-05	498	125	9	36634849
Pubmed	Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.	TDRKH FAT4 CAMK4 PTBP1 CNNM3 SEC24D RBM19 EIF2S3 PI4KB XRN1 PCDH7	1.19e-04	777	125	11	35844135
Pubmed	The RNA-binding protein PTBP1 is necessary for B cell selection in germinal centers.	PTBP2 PTBP1	1.27e-04	5	125	2	29358707
Pubmed	The DWORF micropeptide enhances contractility and prevents heart failure in a mouse model of dilated cardiomyopathy.	ATP2A1 ATP2A2	1.27e-04	5	125	2	30299255
Pubmed	NFAT/Fas signaling mediates the neuronal apoptosis and motor side effects of GSK-3 inhibition in a mouse model of lithium therapy.	GSK3B NFATC4	1.27e-04	5	125	2	20530871
Pubmed	Polypyrimidine tract-binding proteins are essential for B cell development.	PTBP2 PTBP1	1.27e-04	5	125	2	32081131
Pubmed	The hnRNP and cytoskeletal protein raver1 contributes to synaptic plasticity.	PTBP2 PTBP1	1.27e-04	5	125	2	18061163
Pubmed	PTBP1 is required for embryonic development before gastrulation.	PTBP2 PTBP1	1.27e-04	5	125	2	21423341
Pubmed	Candidate DNA methylation drivers of acquired cisplatin resistance in ovarian cancer identified by methylome and expression profiling.	MEST MLH1	1.27e-04	5	125	2	22249249
Pubmed	DNAH11 Localization in the Proximal Region of Respiratory Cilia Defines Distinct Outer Dynein Arm Complexes.	DNAH9 DNAH11	1.27e-04	5	125	2	26909801
Pubmed	Association study of the INPP1, 5HTT, BDNF, AP-2beta and GSK-3beta GENE variants and restrospectively scored response to lithium prophylaxis in bipolar disorder.	GSK3B SLC6A4	1.27e-04	5	125	2	16787706
Pubmed	Proto-oncoprotein TLS/FUS is associated to the nuclear matrix and complexed with splicing factors PTB, SRm160, and SR proteins.	PTBP2 PTBP1	1.27e-04	5	125	2	12581738
Pubmed	An unusually powerful mode of low-frequency sound interference due to defective hair bundles of the auditory outer hair cells.	STRC STRCP1	1.27e-04	5	125	2	24920589
Pubmed	An Integrative Synthetic Biology Approach to Interrogating Cellular Ubiquitin and Ufm Signaling.	IRF3 CRP HINFP	1.39e-04	28	125	3	32545848
Pubmed	Biology, structure and mechanism of P-type ATPases.	ATP12A ATP2A1 ATP2A2	1.55e-04	29	125	3	15071553
Pubmed	Childhood brain tumors, residential insecticide exposure, and pesticide metabolism genes.	FMO1 PON1	1.90e-04	6	125	2	20056567
Pubmed	PTBP1 and PTBP2 Serve Both Specific and Redundant Functions in Neuronal Pre-mRNA Splicing.	PTBP2 PTBP1	1.90e-04	6	125	2	27926877
Pubmed	PSD-95 is post-transcriptionally repressed during early neural development by PTBP1 and PTBP2.	PTBP2 PTBP1	1.90e-04	6	125	2	22246437
Pubmed	Phosphorylation by neuronal cdc2-like protein kinase promotes dimerization of Tau protein in vitro.	GSK3B MAPK12	1.90e-04	6	125	2	9353289
Pubmed	Rapid and differential regulation of AMPA and kainate receptors at hippocampal mossy fibre synapses by PICK1 and GRIP.	GRIK1 GRIP1	1.90e-04	6	125	2	12597860
Pubmed	Mild recessive mutations in six Fraser syndrome-related genes cause isolated congenital anomalies of the kidney and urinary tract.	FREM1 GRIP1	1.90e-04	6	125	2	24700879
Pubmed	CFAP53 regulates mammalian cilia-type motility patterns through differential localization and recruitment of axonemal dynein components.	DNAH9 DNAH11	1.90e-04	6	125	2	33347437
Pubmed	Hyperphosphorylation of tau in PHF.	GSK3B MAPK12	1.90e-04	6	125	2	7566346
Cytoband	7p11.1	FKBP9 FKBP9P1	7.35e-06	2	125	2	7p11.1
GeneFamily	Dyneins, axonemal	DNAH2 DNAH9 DNAH11	5.22e-05	17	79	3	536
GeneFamily	ATPases Ca2+ transporting	ATP2A1 ATP2A2	6.65e-04	9	79	2	1209
GeneFamily	Hyalectan proteoglycans\|V-set domain containing\|Sushi domain containing\|C-type lectin domain containing	PKD1L3 FREM1 ATRNL1	7.59e-04	41	79	3	1298
GeneFamily	DEAH-box helicases	DHX15 DHX29	2.17e-03	16	79	2	500
Coexpression	GSE2405_S_AUREUS_VS_A_PHAGOCYTOPHILUM_NEUTROPHIL_DN	ABCA3 MBLAC2 PTBP1 CNNM3 PI4KB TOR1B NUP188 DNMBP	5.48e-06	200	125	8	M6208
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FAT4 MUC5B ADGRV1 FREM1 SORCS1 HMCN1 DNAH9 DNAH11	5.25e-08	184	125	8	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FAT4 MUC5B ADGRV1 FREM1 SORCS1 HMCN1 DNAH9 DNAH11	5.25e-08	184	125	8	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FAT4 MUC5B ADGRV1 FREM1 SORCS1 HMCN1 DNAH9 DNAH11	5.25e-08	184	125	8	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic-precursor_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MUC5B ADGRV1 FREM1 SORCS1 GRIP1 HMCN1 DNAH9	3.54e-07	160	125	7	c381ec6be8cf887861cc18f831a20db42f953fe1
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic-pre_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MUC5B ADGRV1 FREM1 SORCS1 GRIP1 HMCN1 DNAH9	3.54e-07	160	125	7	25c8f3d2a6d14ff0ca0b965fce89d3ff22f40585
ToppCell	Tracheal-NucSeq-Epithelial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	MUC5B ADGRV1 GRIP1 PTPRJ SLC22A3 SYTL1 DOP1B	1.58e-06	200	125	7	d3af0a706baf66e3f32e67b17dcfc31e5b32ce0e
ToppCell	Tracheal-NucSeq-Epithelial-Epi_submucosal-gland-SMG_Serous\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	ADGRV1 ITPRID1 GRIP1 PTPRJ SLC22A3 PTCH2 GPCPD1	1.58e-06	200	125	7	7c2d499af60654b7b28f172ac2c914ad49fb74b4
ToppCell	Tracheal-NucSeq-Epithelial-Epi_submucosal-gland\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	MUC5B ADGRV1 ITPRID1 GRIP1 PTPRJ SLC22A3 DOP1B	1.58e-06	200	125	7	0eb9ad8c0373bcc62029ec21c590ed03aaacd039
ToppCell	severe-CD4+_T_naive\|World / disease stage, cell group and cell class	KCTD1 GRIP1 GPR161 MAPK12 AARS2 EIF2S3	5.46e-06	157	125	6	ccf9abe0b59e9ea728cec4bba1872ffe14c7385c
ToppCell	TCGA-Skin-Metastatic-Melanoma-Skin_Cutaneous_Melanoma-3\|TCGA-Skin / Sample_Type by Project: Shred V9	MBLAC2 RBM20 CORO2B SLCO1C1 HMCN1 PCDH7	5.88e-06	159	125	6	fb222c42f66901852b01cec073ec0732245ee973
ToppCell	PND07-Epithelial-Epithelial_Airway-Neurosecretory-Secretory\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	GABRP PON1 MUC5B ITPRID1 GRIP1 DNAH11	6.09e-06	160	125	6	028b5261a1da832d52f66fb620db83e5fbbd874a
ToppCell	PND07-Epithelial-Epithelial_Airway-Neurosecretory-Secretory-Secretory_mature\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	GABRP PON1 MUC5B ITPRID1 GRIP1 DNAH11	6.09e-06	160	125	6	1f4ee446436726c3d373f56d87dd80b6a12e8b9e
ToppCell	PND07-28-samps-Epithelial-Epithelial-non_alveolar-Club_cell\|PND07-28-samps / Age Group, Lineage, Cell class and subclass	GABRP PON1 MUC5B ITPRID1 GRIP1 SYTL1	6.54e-06	162	125	6	aed15eef32419b8a4e2afdb9776c2bf2802e96f1
ToppCell	severe-CD4+_T_naive\|severe / disease stage, cell group and cell class	CAMK4 KCTD1 GRIP1 GPR161 MAPK12 AARS2	7.78e-06	167	125	6	02a8215fca59c357c1cdaa5738849eacf98c0bcc
ToppCell	droplet-Lung-nan-18m-Myeloid-Basophil\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NT5C3A MUC5B SLC6A4 MAPK12 AARS2 SYTL1	8.33e-06	169	125	6	f2e20049a17eee533d49bd5f24a51962d123d132
ToppCell	droplet-Lung-nan-18m-Myeloid-basophil\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NT5C3A MUC5B SLC6A4 MAPK12 AARS2 SYTL1	8.33e-06	169	125	6	4c6892551e9dec94fc62b3beab1e6d424639a1e9
ToppCell	BAL-Control-cDC_8\|Control / Compartment, Disease Groups and Clusters	MBLAC2 LCLAT1 GPR161 SEC24D DNMBP IGLON5	1.23e-05	181	125	6	f370161afef2ec827a7b194c06abb9ac1a507cbb
ToppCell	human_hepatoblastoma-Tumor_cells-T5\|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)	EXTL3 FREM1 GSK3B SORCS1 GRIP1 MEST	1.53e-05	188	125	6	b070a0667f1ee9b825b267b6c389b7c42fc436f9
ToppCell	NS-moderate-d_0-4\|moderate / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	DNAH2 KCTD1 ADGRV1 DNAH9 PCDH7 DNAH11	1.77e-05	193	125	6	ea345d34440b25f65358a53dc72831998d1c3620
ToppCell	Parenchymal-NucSeq-Stromal-Myofibroblastic\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	COL6A2 RBM20 EHBP1L1 SLCO1C1 TBC1D1 PCDH7	2.04e-05	198	125	6	bd42c03e384e64f61b02618cf1a5440033bb04b2
ToppCell	Fetal_29-31_weeks-Mesenchymal\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	COL6A2 FAT4 FREM1 MEST HMCN1 PCDH7	2.04e-05	198	125	6	21cf4d81386761d09d0f6829c01c198e5524176d
ToppCell	356C-Epithelial_cells-Epithelial-H_(AT1)-\|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)	MRI1 MYPOP RBM19 BEND7 MLH1	2.08e-05	118	125	5	08bdf7bc3c9dcbc0f690658fe14e6cc4b9581698
ToppCell	356C-Epithelial_cells-Epithelial-H_(AT1)\|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)	MRI1 MYPOP RBM19 BEND7 MLH1	2.08e-05	118	125	5	3b077ad5c68c01b3fcc93f203cb130bb90705af9
ToppCell	Mesenchymal\|World / Lineage, Cell type, age group and donor	COL6A2 FAT4 FREM1 MEST HMCN1 PCDH7	2.10e-05	199	125	6	4bac110c2b3609f6ee5d0e3275da0824a6240270
ToppCell	Parenchymal-NucSeq-Stromal-Myofibroblastic-Muscle_smooth_pulmonary\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	COL6A2 RBM20 EHBP1L1 SLCO1C1 TBC1D1 PCDH7	2.10e-05	199	125	6	b1753474152b82a0b811b9878c890a359e14919a
ToppCell	Bronchial-NucSeq-Epithelial-Epi_submucosal-gland-SMG_Mucous\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	MUC5B EXTL3 GRIP1 SYTL1 ATP12A DOP1B	2.16e-05	200	125	6	ed093626a9cac7531a2bf02f6e345c5e84b8c060
ToppCell	Tracheal-10x3prime_v2-Epithelial-Epi_submucosal-gland-SMG_Serous\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	ITPRID1 GRIP1 HINFP BEND7 SV2C DOP1B	2.16e-05	200	125	6	61bae10c8b12196d9cee766897971b81cb897191
ToppCell	Neuronal-Inhibitory-iA\|Neuronal / cells hierarchy compared to all cells using T-Statistic	FAT4 GRIK1 FREM1 GRIP1 SLC22A3 SV2C	2.16e-05	200	125	6	5ef4a3dc18a44292184a59ced916183c0699b01e
ToppCell	Bronchial-NucSeq-Epithelial-Epi_submucosal-gland\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	MUC5B ITPRID1 GRIP1 SYTL1 ATP12A DOP1B	2.16e-05	200	125	6	85c0f038bcfb42669dca2b80273b0f8a1421405e
ToppCell	Tracheal-NucSeq-Stromal-Fibroblastic-Fibro_peribronchial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	COL6A2 FAT4 FREM1 HMCN1 NFATC4 ATRNL1	2.16e-05	200	125	6	58b38f9a484ee94191091a0659ed62ebed2d4a14
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Principal_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PFAS SLC6A4 STRC ATP12A PCDH7	3.97e-05	135	125	5	7b456fa9a5f5ce58976a8f1fad18c0f96a096930
ToppCell	PCW_05-06-Mesenchymal-Mesenchymal_fibroblastic-mes_immature3_(17)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	COL6A2 FREM1 MEST SLCO1C1 PCDH7	5.40e-05	144	125	5	1c001a5a3bbe4ecbce8305f8b260e933033550dd
ToppCell	Children_(3_yrs)-Epithelial-lung_goblet_cell-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	GABRP MUC5B GRIP1 ATP12A PCDH7	9.15e-05	161	125	5	2d63b279d9a5132e1c09b03930bf9039036d24a2
ToppCell	PND03-Epithelial-Epithelial_Airway-Neurosecretory-Secretory-Secretory_mature\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	GABRP PON1 MUC5B ITPRID1 ADH4	9.15e-05	161	125	5	c4970501c038ed36de447da70eabff020ad78713
ToppCell	PND03-Epithelial-Epithelial_Airway-Neurosecretory-Secretory\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	GABRP PON1 MUC5B ITPRID1 ADH4	9.15e-05	161	125	5	41a89a3d99a9bd6039a3d881d1d9dcd18bc07f25
ToppCell	LPS-IL1RA+antiTNF-Epithelial_airway\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	GABRP DNAH2 MUC5B DNAH9 DNAH11	9.98e-05	164	125	5	e4d4c59aebe5cacd4ecdb907facd044dc82a831d
ToppCell	facs-Trachea-24m-Mesenchymal-fibroblast-fibroblast_of_trachea-tracheal_fibroblast_l15\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	COL6A2 FREM1 LCLAT1 ZXDB PCDH7	1.09e-04	167	125	5	55c3c68af269fcf40f2b080ae4489523609ad388
ToppCell	TCGA-Stomach-Primary_Tumor-Stomach_Adenocarcinoma-Stomach_Adenocarcinoma_-_Diffuse-3\|TCGA-Stomach / Sample_Type by Project: Shred V9	CAMK4 WDFY4 SLCO1C1 HMCN1 PTCH2	1.09e-04	167	125	5	d2230c894ccf9dbba9196e079ae81f384d43da63
ToppCell	droplet-Lung-18m-Hematologic-myeloid-Basophil/Mast_cell-basophil_l26\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	NT5C3A MUC5B SLC6A4 AARS2 SYTL1	1.12e-04	168	125	5	0e99ecd94ab8e5372e30433d7d0aa76b4d54257a
ToppCell	droplet-Lung-18m-Hematologic-myeloid-Basophil/Mast_cell\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	NT5C3A MUC5B SLC6A4 AARS2 SYTL1	1.12e-04	168	125	5	34722e14f28313f2e4644b3c1861ef12958cee9f
ToppCell	tumor_Lymph_Node_/_Brain-T/NK_cells-CD8+/CD4+_Mixed_Th\|T/NK_cells / Location, Cell class and cell subclass	GRK4 ADGRV1 GDE1 DNMBP PCDH7	1.28e-04	173	125	5	42c911ed16fabdabef063830e8407192d8bde950
ToppCell	PND01-03-samps-Endothelial-Postnatal_endothelial-capillary_endothelial_Hpgd-CA4_high\|PND01-03-samps / Age Group, Lineage, Cell class and subclass	FMO1 ZNF407 IDO2 CORO2B DNMBP	1.32e-04	174	125	5	cb0109661e8c9ca04d67d33f2d926f0e649bf67d
ToppCell	E16.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-SCMF-SCMF_mature\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	HECTD4 KCTD1 EXTL3 AARSD1 PCDH7	1.35e-04	175	125	5	1d8aab491dcc27ea5dbfb6462d18ee280b21a05e
ToppCell	E16.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-SCMF\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	HECTD4 KCTD1 EXTL3 AARSD1 PCDH7	1.35e-04	175	125	5	427a7ee92fe16a90625946492062d37aa0f7235b
ToppCell	facs-Marrow-B-cells-24m\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADGRV1 FREM1 SORCS1 HMCN1 DNAH9	1.35e-04	175	125	5	887e75fc90e59a6394d62f3c048a9cfdf6707725
ToppCell	facs-MAT-Fat-3m-Epithelial-nan\|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADGRV1 SLC6A4 PRKAR2B DNAH11	1.37e-04	93	125	4	dbfaa7f23d25f5c286ab7ca3ca795b734cb95153
ToppCell	facs-MAT-Fat-3m-Epithelial-epithelial_cell\|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADGRV1 SLC6A4 PRKAR2B DNAH11	1.37e-04	93	125	4	0d6d1d8dd9c91ba31eb35a4b5979d087890936c1
ToppCell	facs-MAT-Fat-3m-Epithelial\|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADGRV1 SLC6A4 PRKAR2B DNAH11	1.37e-04	93	125	4	abffb1fd5a919b7c08e62e1c3c08a8dd8783a4ca
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Intercalated_Cell_Type_B\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ASXL1 ITPRID1 FREM1 TBC1D1 DOP1B	1.39e-04	176	125	5	6c7edf1cb38644500bce6c5a1dd90bbe17415cdb
ToppCell	Fetal_29-31_weeks-Epithelial-lung_goblet_cell\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	MUC5B ADGRV1 ITPRID1 GRIP1 ATP12A	1.43e-04	177	125	5	a4c001a8e44142babf9f24dfe6f7b73a70b11b16
ToppCell	Fetal_29-31_weeks-Epithelial-lung_goblet_cell-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	MUC5B ADGRV1 ITPRID1 GRIP1 ATP12A	1.43e-04	177	125	5	363e07b0f347f3716d530a28ead854b98e27d37c
ToppCell	390C-Lymphocytic-CD4_T-cell-Treg_cell_2\|390C / Donor, Lineage, Cell class and subclass (all cells)	EPHX2 MRI1 HECTD4 ATG2A COCH	1.46e-04	178	125	5	829ea00c022a78d1861aa3ec53503272976775d9
ToppCell	TCGA-Colorectal-Primary_Tumor-Colorectal_Adenocarcinoma-Rectal_Adenocarcinoma-7\|TCGA-Colorectal / Sample_Type by Project: Shred V9	ASXL1 TDRKH FKBP9 SLC6A4 HMCN1	1.46e-04	178	125	5	edc76b8f15056ec1c9a1c61a048b6331a92592d6
ToppCell	PBMC-Severe-cDC_11\|Severe / Compartment, Disease Groups and Clusters	TDRKH HLA-DPA1 WDFY4 GPR161 MAPK12	1.46e-04	178	125	5	0667abc05eb2254710b9c648c65b7cfdfe7831b7
ToppCell	Dendritic_Cells-IPF_01\|World / lung cells shred on cell class, cell subclass, sample id	GBP7 HLA-DPA1 DHX15 IDO2 IGLON5	1.46e-04	178	125	5	3a28103cf282cc3637d1875a3b4cd7ddf3207687
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Intercalated_Cell_Type_B\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ASXL1 FREM1 TBC1D1 DOP1B DNAH11	1.54e-04	180	125	5	cfc8bfbfd3617aabbb49f9730c29b673ca157e74
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_C_(IT_L4_RORB)-Exc_L2-4_RORB_GRIK1\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	GRIK1 KCTD1 SORCS1 KCND2 ATRNL1	1.58e-04	181	125	5	57994ff4ecffb15653aee00644d9f887f5e3461d
ToppCell	Club-club-8\|World / Class top	GABRP FMO1 PON1 MUC5B ITPRID1	1.62e-04	182	125	5	8111d917e588008d947021460ddf8f1e7ae1337a
ToppCell	Children_(3_yrs)-Epithelial-lung_goblet_cell\|Children_(3_yrs) / Lineage, Cell type, age group and donor	GABRP MUC5B GRIP1 ATP12A PCDH7	1.62e-04	182	125	5	3f1a666fe27dd7529c114539ed5f6b8ca585c875
ToppCell	B_cells-ISG-high_B_cells\|World / Immune cells in Kidney/Urine in Lupus Nephritis	HLA-DPA1 NT5C3A WDFY4 XRN1 ATP12A	1.67e-04	183	125	5	dc2b00e920efa1dcc2a6265cd1024e3249c9974f
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	FREM1 SLC52A3 GRIP1 TBC1D1 PCDH7	1.75e-04	185	125	5	3d73b3e0bceb192257e5cfbe64b7ccb379b6e22d
ToppCell	facs-Brain_Non-Myeloid-Cerebellum_-18m-Endothelial-Endothelial_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FMO1 GBP7 SLCO1C1 HMCN1 GPCPD1	1.80e-04	186	125	5	ba6ba75218efc26371cea24ddbb0e9b3e3f421ac
ToppCell	facs-Brain_Non-Myeloid-Cerebellum_-18m-Endothelial\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FMO1 GBP7 SLCO1C1 HMCN1 GPCPD1	1.80e-04	186	125	5	65e25a9dcef5fc71510aaf170e220deef5b2feb2
ToppCell	droplet-Lung-nan-21m-Lymphocytic-T_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TDRKH CAMK4 NT5C3B SV2C STRC	1.80e-04	186	125	5	8fc0487fc1b2fd403bd7c257fcabbff652f971c9
ToppCell	facs-Brain_Non-Myeloid-Cerebellum_-18m-Endothelial-endothelial_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FMO1 GBP7 SLCO1C1 HMCN1 GPCPD1	1.80e-04	186	125	5	e4f1259725160719e5fd13d76e5a707efed70013
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Non-neuronal-Macroglial-Astro-Astrocyte-Astro_L1_FGFR3_MT1G\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ADGRV1 SERPINI2 SLCO1C1 NFATC4 ARHGEF26	1.84e-04	187	125	5	2b1b2c3792d6c9ab69675ce88842bb589414b530
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	FREM1 GRIP1 CORO2B TBC1D1 PCDH7	1.84e-04	187	125	5	2d17408b3b5f09d135084fd7ccce98e6b5ca632b
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	FREM1 SLC52A3 GRIP1 CORO2B PCDH7	1.89e-04	188	125	5	58ccb31cdf43167872ef0fc737e6f9c51ee2e060
ToppCell	COVID_vent-Myeloid-Monocytic-SC_&_Eosinophil\|COVID_vent / Disease condition, Lineage, Cell class and subclass	FREM1 MEST MAPK12 BEND7 PDZD8	1.94e-04	189	125	5	2157a2d40613f7d5ce2e7dbd266df441e449cdaf
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	KCTD1 SORCS1 SEC24D ATRNL1 PCDH7	1.94e-04	189	125	5	a75226616340045b581d08429d2e123e041dee55
ToppCell	moderate-Lymphoid-NK\|Lymphoid / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	COL6A2 FAT4 FKBP9 SORCS1 CORO2B	1.94e-04	189	125	5	22a19365782003c18ec8dddcdbfdaa82c4e330f6
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CAMK4 KCTD1 SORCS1 ATRNL1 PCDH7	1.98e-04	190	125	5	d594da827e3c16644952b9589cc12b947ce36279
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	COL6A2 GRIK1 HMCN1 SLC22A3 PCDH7	1.98e-04	190	125	5	562ee3b025c29edf07b8b344323edb49d82f1c7e
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	COL6A2 GRIK1 HMCN1 SLC22A3 PCDH7	1.98e-04	190	125	5	f5fb989afabb49d64d91324570cd8c80a4b9e67d
ToppCell	COVID-19-Epithelial_cells-Airway_goblet\|COVID-19 / group, cell type (main and fine annotations)	MUC5B ADGRV1 ITPRID1 GRIP1 ATP12A	1.98e-04	190	125	5	51ca9ef4df3220487152fcf684147730637c7cc1
ToppCell	LPS_only-Stromal_mesenchymal-Matrix_Fibroblast-Diff_MatrixFB\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	COL6A2 FREM1 ADH4 MEST PCDH7	1.98e-04	190	125	5	d60395739458d7f47a3350ade751fe3819500320
ToppCell	droplet-Liver-Hepatocytes-24m-Epithelial-Hepatocyte_(Midlobular)\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EPHX2 PON1 ADH4 MYPOP	2.03e-04	103	125	4	3a0f02ce52c4e2eda5b987c89317280c08f90cb3
ToppCell	E18.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	EPHX2 COL6A2 FMO1 HMCN1 PCDH7	2.03e-04	191	125	5	4b50fdd310701251e64e16cd2d07ce03dbfd3e3e
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L1_LAMP5_NDNF\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	GRIK1 FREM1 GRIP1 GPR161 SV2C	2.03e-04	191	125	5	7b386512284dfaa0e95358b28ee82632ee965e64
ToppCell	E18.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2-AF2_mature\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	EPHX2 COL6A2 FMO1 HMCN1 PCDH7	2.03e-04	191	125	5	75d2197076a9dfc868e8baf95bd4c5e44f438e3e
ToppCell	Children_(3_yrs)-Mesenchymal-matrix_fibroblast_2_cell-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	COL6A2 FAT4 FMO1 FREM1 PCDH7	2.08e-04	192	125	5	e0f4e4470a71bfa81d9dcd8594e5f82aafc24f81
ToppCell	Mesenchymal-matrix_fibroblast_1_cell\|World / Lineage, Cell type, age group and donor	COL6A2 FAT4 FREM1 HMCN1 PCDH7	2.13e-04	193	125	5	acad568621ed677031797b8c2e34dafea798d681
ToppCell	PCW_07-8.5-Mesenchymal-Mesenchymal_fibroblastic-mes_immature_adventitial_fibro_(9)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	COL6A2 FREM1 MEST KCND2 PCDH7	2.18e-04	194	125	5	5f5f0cdeacd5e1b28717d78dabdb9eb95f661e36
ToppCell	Fetal_29-31_weeks-Mesenchymal-matrix_fibroblast_2_cell-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	COL6A2 FAT4 FMO1 PTCH2 PCDH7	2.18e-04	194	125	5	439d3f17c1f4736122b330e98add9292c7036a8e
ToppCell	Tracheal-10x3prime_v2-Epithelial-Epi_submucosal-gland\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	MUC5B ITPRID1 GRIP1 SV2C STRC	2.18e-04	194	125	5	e90f6717e3421f8978d1fc1b2f30dcf69f6fcce7
ToppCell	PCW_05-06-Mesenchymal-Mesenchymal_fibroblastic-mes_immature5_(6)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	COL6A2 FREM1 MEST PTCH2 PCDH7	2.24e-04	195	125	5	c5d2d9f12fd893331c9de261af30607d845d4f6a
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	COL6A2 SEC24D ATRNL1 ARHGEF26 PCDH7	2.24e-04	195	125	5	49c99553629cdd83ee56a2e508d5bc8d34b8507b
ToppCell	Smart-seq2-spleen_(Smart-seq2)-myeloid-myeloid_granulocytic-neutrophil\|spleen_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	ADGRV1 PKD1L3 HMCN1 ITIH6 DNAH9	2.24e-04	195	125	5	d3755929ebbbf5e3afde44281e9056ddb614a291
ToppCell	Smart-seq2-spleen_(Smart-seq2)-myeloid-myeloid_granulocytic\|spleen_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	ADGRV1 PKD1L3 HMCN1 ITIH6 DNAH9	2.24e-04	195	125	5	19853c654ac64b3ae3bc99841c6cb29c8aaba85c
ToppCell	PCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_immature3_(17)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	COL6A2 FAT4 FREM1 MEST PCDH7	2.24e-04	195	125	5	1cdf5f296029ae424d9dba42e86a6d111e4896e6
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	COL6A2 SEC24D ATRNL1 ARHGEF26 PCDH7	2.24e-04	195	125	5	dd281a249854800f737dc22e0f375f66dfb5cf5f
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	COL6A2 KCND2 ATRNL1 PTCH2 PCDH7	2.24e-04	195	125	5	3c3703f092b6fc1b7333426fb5e2823bfb74bb57
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	COL6A2 FAT4 CAMK4 FREM1 ATRNL1	2.29e-04	196	125	5	a12dd986df65c36f248cf10815c3b8b6238613b0
ToppCell	PCW_05-06-Mesenchymal\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	COL6A2 FAT4 FREM1 MEST PCDH7	2.29e-04	196	125	5	dca52c57ba35d9395cdbca8b881f12ece721b10f
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c09-GZMK-FOS_l\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	ATG2A GDE1 CNNM3 SYTL1 D2HGDH	2.29e-04	196	125	5	072e0e29be4639344ead4ea6ad521e3338f5f8af
ToppCell	PCW_05-06-Mesenchymal-Mesenchymal_fibroblastic-mes_immature1_(0)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	COL6A2 FREM1 MEST KCND2 PCDH7	2.29e-04	196	125	5	22538376a95fe3afe8639a216a5497087aa94110
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_fibroblastic\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	COL6A2 FAT4 FREM1 MEST PCDH7	2.29e-04	196	125	5	1450cb69c5bf469e97c03bf1890f6f7c54165b8a
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	COL6A2 FAT4 CAMK4 FREM1 ATRNL1	2.29e-04	196	125	5	3e6803587d8566fd08cb8b290be3b6461743d79c
ToppCell	hematopoetic_progenitors-CD34+_MEP_1\|hematopoetic_progenitors / Lineage and Cell class	NT5C3A FREM1 MEST PRKAR2B PDZD8	2.34e-04	197	125	5	6172a1b98ff840d9174b1ab20ba0c202a7ef87af
ToppCell	Tracheal-10x5prime-Stromal-Peri/Epineurial_\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	COL6A2 FMO1 SLCO1C1 SLC22A3 PTCH2	2.34e-04	197	125	5	2cb1f557ce1400398975de94638126b4522567f3
Drug	1i32	COL6A2 ABCA3 GRK4 ADGRV1 CRP CHRNE XRN1 MLH1	4.49e-07	129	121	8	CID000446186
Drug	Cinoxacin [28657-80-9]; Up 200; 15.2uM; HL60; HT_HG-U133A	PON1 GRIK1 EXTL3 SSTR5 SLCO1C1 NFATC4 SV2C ATP12A DNMBP	1.26e-06	200	121	9	2722_UP
Drug	magnesium	NT5C3A LDHAL6B NT5C3B GRIK1 ADGRV1 GTPBP10 GSK3B YARS2 ACTR1A CNNM3 MAPK12 AARS2 KCND2 EIF2S3 MLH1 PRKAR2B ATP12A ATP2A1 ATP2A2 DNAH9 DNAH11	6.25e-06	1325	121	21	CID000000888
Disease	Congestive heart failure	EPHX2 PON1 GSK3B CRP PRKAR2B ATP2A1 ATP2A2	4.11e-07	110	123	7	C0018802
Disease	Heart failure	EPHX2 PON1 GSK3B CRP PRKAR2B ATP2A1 ATP2A2	4.11e-07	110	123	7	C0018801
Disease	Left-Sided Heart Failure	EPHX2 PON1 GSK3B CRP PRKAR2B ATP2A1 ATP2A2	4.11e-07	110	123	7	C0023212
Disease	Heart Failure, Right-Sided	EPHX2 PON1 GSK3B CRP PRKAR2B ATP2A1 ATP2A2	4.11e-07	110	123	7	C0235527
Disease	Heart Decompensation	EPHX2 PON1 GSK3B CRP PRKAR2B ATP2A1 ATP2A2	4.11e-07	110	123	7	C1961112
Disease	Myocardial Failure	EPHX2 PON1 GSK3B CRP PRKAR2B ATP2A1 ATP2A2	4.11e-07	110	123	7	C1959583
Disease	myocardial infarction	TDRKH HECTD4 PKD1L3 SLC6A4 SEC24D EHBP1L1 DNMBP ARHGEF26 ATP2A2	1.69e-05	350	123	9	EFO_0000612
Disease	MEHMO syndrome (implicated_via_orthology)	EIF2S3B EIF2S3	1.72e-05	2	123	2	DOID:0060801 (implicated_via_orthology)
Disease	autosomal recessive nonsyndromic deafness 16 (implicated_via_orthology)	STRC STRCP1	1.72e-05	2	123	2	DOID:0110471 (implicated_via_orthology)
Disease	Brody myopathy (implicated_via_orthology)	ATP2A1 ATP2A2	5.16e-05	3	123	2	DOID:0050692 (implicated_via_orthology)
Disease	Fraser syndrome (implicated_via_orthology)	FREM1 GRIP1	1.03e-04	4	123	2	DOID:0090001 (implicated_via_orthology)
Disease	retinal vein occlusion (is_marker_for)	PON1 CRP	1.03e-04	4	123	2	DOID:1727 (is_marker_for)
Disease	heart disease (is_implicated_in)	CRP SLC6A4	1.71e-04	5	123	2	DOID:114 (is_implicated_in)
Disease	respiratory failure, COVID-19	HLA-DPA1 FREM1 PCDH7	2.39e-04	29	123	3	EFO_0009686, MONDO_0100096
Disease	bipolar disorder (is_implicated_in)	SSTR5 GSK3B SLC6A4	2.39e-04	29	123	3	DOID:3312 (is_implicated_in)
Disease	hypopituitarism (implicated_via_orthology)	EIF2S3B EIF2S3	2.56e-04	6	123	2	DOID:9406 (implicated_via_orthology)
Disease	MEDULLOBLASTOMA	GPR161 PTCH2	2.56e-04	6	123	2	155255
Disease	Myocarditis	CRP SLC22A3	2.56e-04	6	123	2	C0027059
Disease	Carditis	CRP SLC22A3	2.56e-04	6	123	2	C0869523
Disease	heavy drinking	PON1 GRIK1	2.56e-04	6	123	2	C0687132
Disease	Medulloblastoma	GPR161 PTCH2	2.56e-04	6	123	2	cv:C0025149
Disease	esophageal carcinoma	HECTD4 ADH4 ATP2A2	2.64e-04	30	123	3	EFO_0002916
Disease	Alcoholic Intoxication	PON1 GRIK1 SLC6A4	3.21e-04	32	123	3	C0001969
Disease	heart disease (implicated_via_orthology)	GSK3B ATP2A1 ATP2A2	5.36e-04	38	123	3	DOID:114 (implicated_via_orthology)
Disease	leukodystrophy (implicated_via_orthology)	EIF2S3B EIF2S3	6.09e-04	9	123	2	DOID:10579 (implicated_via_orthology)
Disease	Glioma	GPR161 PTCH2	6.09e-04	9	123	2	cv:C0017638
Disease	X-21467 measurement	SLCO1C1 DNMBP	6.09e-04	9	123	2	EFO_0020007
Disease	Melancholia	PON1 GSK3B SLC6A4	6.71e-04	41	123	3	C0025193
Disease	Depression, Neurotic	PON1 GSK3B SLC6A4	6.71e-04	41	123	3	C0282126
Disease	Depressive Syndrome	PON1 GSK3B SLC6A4	7.21e-04	42	123	3	C0086133
Disease	Metabolic Diseases	PON1 CRP	7.59e-04	10	123	2	C0025517
Disease	medulloblastoma (is_implicated_in)	GPR161 PTCH2	7.59e-04	10	123	2	DOID:0050902 (is_implicated_in)
Disease	otitis media (is_marker_for)	MUC5B CRP	7.59e-04	10	123	2	DOID:10754 (is_marker_for)
Disease	Unipolar Depression	PON1 SSTR5 GSK3B GDE1 CRP SLC6A4	7.79e-04	259	123	6	C0041696
Disease	Diabetic Retinopathy	PON1 CRP	9.25e-04	11	123	2	C0011884
Disease	obstructive sleep apnea (is_implicated_in)	CRP SLC6A4	9.25e-04	11	123	2	DOID:0050848 (is_implicated_in)
Disease	Heart Diseases	PON1 CRP ATP2A2	9.41e-04	46	123	3	C0018799
Disease	Endogenous depression	PON1 GSK3B SLC6A4	9.41e-04	46	123	3	C0011573
Disease	calcium measurement	DNAH2 CHRNE HINFP CNNM3 EHBP1L1 SLC22A3 GPCPD1 PRKAR2B ATP2A2	1.30e-03	628	123	9	EFO_0004838
Disease	Depressed mood	CRP SLC6A4	1.30e-03	13	123	2	C0344315
Disease	response to TNF antagonist	PON1 PKD1L3 SLCO1C1	1.50e-03	54	123	3	EFO_0004653
Disease	Hamman-Rich syndrome	ABCA3 MUC5B	1.52e-03	14	123	2	C0085786
Disease	orotic acid measurement	NT5C3A DNAH11	1.52e-03	14	123	2	EFO_0010516
Disease	Kuhnt-Junius degeneration (is_marker_for)	PON1 CRP	1.52e-03	14	123	2	DOID:10873 (is_marker_for)
Disease	factor XI measurement, fibrinogen measurement, tissue plasminogen activator measurement, factor VII measurement	HECTD4 PKD1L3 ADH4	1.67e-03	56	123	3	EFO_0004619, EFO_0004623, EFO_0004694, EFO_0004791
Disease	fibrinogen measurement, factor VII measurement	HECTD4 PKD1L3 ADH4	1.85e-03	58	123	3	EFO_0004619, EFO_0004623
Disease	Hyperlipoproteinemia Type IIa	EPHX2 PON1	1.99e-03	16	123	2	C0745103
Disease	Kuhnt-Junius degeneration (is_implicated_in)	PON1 CRP	2.25e-03	17	123	2	DOID:10873 (is_implicated_in)
Disease	metabolite measurement	EPHX2 MRI1 FMO1 PON1 WDFY4 SORCS1 MAPK12 DNMBP	2.45e-03	560	123	8	EFO_0004725
Disease	essential hypertension (is_implicated_in)	GRK4 ATP2A2	2.52e-03	18	123	2	DOID:10825 (is_implicated_in)
Disease	Coronary Arteriosclerosis	HECTD4 PON1 CRP	2.56e-03	65	123	3	C0010054
Disease	Coronary Artery Disease	HECTD4 PON1 CRP	2.56e-03	65	123	3	C1956346
Disease	Hereditary Non-Polyposis Colon Cancer Type 2	PTPRJ MLH1	2.81e-03	19	123	2	C1333991
Disease	susceptibility to mononucleosis measurement	FAT4 DNAH2 PCDH7	3.03e-03	69	123	3	EFO_0008403
Disease	neurodegenerative disease (implicated_via_orthology)	FAT4 PON1 GRIK1 PTCH2	3.23e-03	145	123	4	DOID:1289 (implicated_via_orthology)
Disease	Metabolic Syndrome X	PON1 CRP	3.44e-03	21	123	2	C0524620
Disease	Idiopathic Pulmonary Fibrosis	ABCA3 MUC5B	3.44e-03	21	123	2	C1800706
Disease	serum albumin measurement	ADGRV1 PKD1L3 ADH4 HINFP EHBP1L1 PTPRJ PRKAR2B PCDH7	3.44e-03	592	123	8	EFO_0004535
Disease	serum alanine aminotransferase measurement	DAGLB HLA-DPA1 HECTD4 DNAH2 PTBP1 SLC6A4 PTPRJ MLH1 TOR1B DNMBP	3.51e-03	869	123	10	EFO_0004735
Disease	Major Depressive Disorder	SSTR5 GSK3B GDE1 CRP SLC6A4	3.57e-03	243	123	5	C1269683

Protein segments in the cluster

Peptide	Gene	Start	Entry
SIPVFIFSAGIGDVL	NT5C3A	196	Q9H0P0
PLFIFSAGIGDILEE	NT5C3B	151	Q969T7
GLTIFPEELIIGRTI	ADH4	306	P08319
VLRIGGIFETVENEP	GRIK1	36	P39086
ELTIILQGLDGPVFT	FAT4	1616	Q6V0I7
FVPIIGFLILEEGET	ADGRV1	2886	Q8WXG9
GELVTEGVAESLFLP	HLA-DPA1	156	P20036
VTDDIPVFLGLVGDL	DNAH11	2106	Q96DT5
GIALIGEPAVIFLDE	ABCA3	1526	Q99758
FQVVLEDTVLFPEGG	AARSD1	41	Q9BTE6
SVSEELPLFVGDIIE	DNMBP	16	Q6XZF7
EGFVELLGPLRTVDE	DNMBP	196	Q6XZF7
LLITDFPVEDGGTLL	ARHGEF26	46	Q96DR7
TSLTIDGVVFVIDPG	DHX15	426	O43143
GITIPDVVFVIDTGR	DHX29	936	Q7Z478
GEETITAFVEPFVIL	ATP2A1	81	O14983
ELVEGFVGSIEVAVP	ATG2A	71	Q2TAZ0
FLLPEVDRQVGTDGL	ASXL1	286	Q8IXJ9
DFGGIETLRVPSELV	CHRNE	91	Q04844
EEGLILFDQIPVSSG	MUC5B	5156	Q9HC84
VLLPEGGITAIVEFL	RBM19	616	Q9Y4C8
GGITAIVEFLEPLEA	RBM19	621	Q9Y4C8
DVFSELSIPLGVEFV	RBM20	1141	Q5T481
SGIPDTVFDLVELEV	LRRC8A	436	Q8IWT6
DIGITDATVTELIPG	PTPRJ	676	Q12913
EIDPVEILLDLGFGA	ITPRID1	141	Q6ZRS4
EGDFTGVLLPELVVS	HERC2	1126	O95714
PTEISLVLELVTGGE	CAMK4	111	Q16566
PIGTITILFIDLGTD	ATP12A	816	P54707
AFIVGLLPGLEEGSE	DOP1B	146	Q9Y3R5
FLQPLGGVATAEEEV	KIAA2026	101	Q5HYC2
ITGDAFVPGERSVII	LCLAT1	106	Q6UWP7
PDGFLEIGNLETIIS	IDO2	156	Q6ZQW0
LELSPVERGVVSIFG	FGF4	116	P08620
GEVPGSAVLVFDIEL	FKBP9P1	31	Q75LS8
GIDEEVFLSIPCILG	LDHAL6B	331	Q9BYZ2
EGTVFVLAVGVVLSP	OR2W3	196	Q7Z3T1
LFEIDPTSGVVSLVG	PCDH7	791	O60245
IGRLFDGTEPIVLDS	KCTD1	56	Q719H9
EGLSLRDVFLGETVP	PDZD8	141	Q8NEN9
TITLVVSDGEAGPFV	FREM1	976	Q5H8C1
GSGFPETRTLEIEIL	EHBP1L1	591	Q8N3D4
DEELAFFGLIPEIIG	KCND2	116	Q9NZV8
ILDVAGSIFIAALPG	GBP7	596	Q8N8V2
LELLVTEPGDGGIFT	LRFN3	351	Q9BTN0
EDVSGGLPFLVDLAL	HECTD4	766	Q9Y4D8
GDEALPTVLVGVFIE	PLOD1	281	Q02809
EPGISILEDGTLLVI	HMCN1	1311	Q96RW7
DPFTNELVIFITGGL	OR1G1	191	P47890
VPGSAVLVFDIELLE	FKBP9	461	O95302
GEETITAFVEPFVIL	ATP2A2	81	P16615
VELDIEFTSDGIPVL	GDE1	96	Q9NZC3
TPEEFSILITEVGLG	IGLON5	91	A6NGN9
LPAVFGVLGRTEEAL	EPHX2	16	P34913
PLESEIIIDDGQFGI	GPCPD1	101	Q9NPB8
IIPISAVTGEGIEEL	GTPBP10	321	A4D1E9
PLIEEEIDGLSGLLF	CORO2B	261	Q9UQ03
ATVVSIIIVFDPLGG	DAGLB	146	Q8NCG7
LFEALEVGAVPVVLG	EXTL3	451	O43909
EFVLNDELPGRIITG	FMO1	281	Q01740
LEIVGFIDIADISSP	INTS14	251	Q96SY0
PVDIVFLLDGSERLG	COL6A2	831	P12110
IFPGDSGVDQLVEII	GSK3B	256	P49841
GGSEILFEVPEVTVA	CRP	96	P02741
LLFRPDLIGEESEGI	ACTR1A	261	P61163
LEVGAEQTEFLRGPL	ATRNL1	1286	Q5VV63
DVVIDTGLGLRSLPE	MBLAC2	41	Q68D91
LIIFLTDGEPTAGVT	ITIH6	391	Q6UXX5
INLFGEEALPGVLVT	GPR161	476	Q8N6U8
PAGLTELLQGFTVEV	PRKAR2B	6	P31323
PEESRVLGFGIVLES	BEND7	261	Q8N7W2
LGEEISLNPSVGIFI	DNAH9	1956	Q9NYC9
QILGAVGALPEIFTE	EIF2S3B	356	Q2VIR3
TEVVLTADPVTGFGI	GRIP1	471	Q9Y3R0
IRISDLGLATEIPEG	GRK4	326	P32298
ESSLQGIILETVPGE	HINFP	421	Q9BQA5
EFTGLEPIVSDVIRG	COCH	526	O43405
PDSTLIAEIILFGEG	DNAH2	1931	Q9P225
IDFFISGVVELPGAL	SLC22A3	381	O75751
EIGVFSLGVPVDALF	KCTD3	271	Q9Y597
DSVGVVGSPEIVVLL	MEST	61	Q5EB52
VGGSVPVFDEIILST	D2HGDH	136	Q8N465
FGGEPVQIALTLDIA	GABRP	56	O00591
GTAVLEVTSIEPFGV	NUP210L	1351	Q5VU65
DLGPFIVDLITFTEG	IRF3	321	Q14653
ESLGRNIFLGEVEVP	SYTL1	356	Q8IYJ3
EVPIIFTLLGVGTVT	SLC52A3	71	Q9NQ40
GVEVFVVGFVLPSAE	SV2C	166	Q496J9
GSEDLEILPNGLAFI	PON1	51	P27169
LPGEVTETEVIALGL	PTBP2	66	Q9UKA9
FEEFLTVGIDIVPAV	BMT2	181	Q1RMZ1
GFRDSVPIQGITLEE	NFATC4	866	Q14934
LTGEDVFGITVPLIT	YARS2	261	Q9Y2Z4
TQVLPFLALGIGVDD	PTCH2	456	Q9Y6C5
EEVFALDPVLGTFLI	PKD1L3	1641	Q7Z443
GIITELGVFAPEELR	MRI1	336	Q9BV20
SLGILIFVLIEGDFP	IMPG2	11	Q9BZV3
FSLEIDEEGNLIGLP	MLH1	626	P40692
SVITEGVGELSVIDP	PI4KB	31	Q9UBF8
SLPLLVFADVQEGGT	SSTR5	171	P35346
VLETLGPLVGFLGTE	STRC	1321	Q7RTU9
IFTEIGTIAAGIPDL	STRC	1656	Q7RTU9
FLGSLVPVVVETLGD	AARS2	371	Q5JTZ9
VTDVGEVFVPLLDGF	SEC24D	511	O94855
LVFLVGEVVPAAVSG	CNNM3	231	Q8NE01
PETELAVIFGESIAL	TAS2R7	261	Q9NYW3
DFFLVLLDPVGGDVE	ZXDB	91	P98169
EDVGDERVLLISGFP	TDRKH	91	Q9Y2W6
IVIFFGLLVSPEEIG	SLC37A3	221	Q8NCC5
VLSVLFAEEPGLVLE	PFAS	941	O15067
IPSSLVGVIDGSFEI	SLCO1C1	76	Q9NYB5
EVSVDFGLQLVGSLP	TBC1D1	16	Q86TI0
APEVSEAVSLILGFV	WDFY4	281	Q6ZS81
EVLFDEEFPGGLTIR	XRN1	1141	Q8IZH2
SVDEILGPLTEILEG	NUP188	1176	Q5SRE5
FSGEEFGPLTRLVLV	SERPINI2	166	O75830
EGLGFTLTVVPEEEI	SERPINA13P	101	Q6UXR4
VIFGSPLTEEGIAQI	ARHGAP19	111	Q14CB8
PLFTGETVSLVDVDI	SOCS7	281	O14512
TAGFEPVVIENVLEG	SEPSECS	181	Q9HD40
EVLETLGPLVGFLGT	STRCP1	1321	A6NGW2
TPLEVLEDIIGFALA	TTC37	1046	Q6PGP7
EEGLIATGVRISELP	ZNF407	1376	Q9C0G0
FVDGVLGEPGEETLI	SORCS1	631	Q8WY21
GEALVGVTEPLFQLD	VSIG10L2	191	P0DP72
AGLEGVITAVLDEFP	SLC6A4	441	P31645
LPIDVTEGEVISLGL	PTBP1	66	P26599
VVAAFEPITVGLAIG	TOR1B	21	O14657
QVLGAVGALPEIFTE	EIF2S3	356	P41091
VIGLLDVFTPDETLD	MAPK12	86	P53778
AEEETIFAILGPGVA	MYPOP	111	Q86VE0