Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	arachidonate 12(S)-lipoxygenase activity	ALOX12 ALOX12B ALOX15	6.93e-09	4	25	3	GO:0004052
GeneOntologyMolecularFunction	hepoxilin-epoxide hydrolase activity	ALOX12 ALOX15	1.50e-06	2	25	2	GO:0047977
GeneOntologyMolecularFunction	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	ALOX12 ALOX12B ALOX15	3.92e-06	25	25	3	GO:0016702
GeneOntologyMolecularFunction	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen	ALOX12 ALOX12B ALOX15	4.42e-06	26	25	3	GO:0016701
GeneOntologyMolecularFunction	linoleate 13S-lipoxygenase activity	ALOX12 ALOX15	4.51e-06	3	25	2	GO:0016165
GeneOntologyMolecularFunction	arachidonate 15-lipoxygenase activity	ALOX12 ALOX15	4.51e-06	3	25	2	GO:0050473
GeneOntologyMolecularFunction	iron ion binding	CYP4F3 ALOX12 ALOX12B ALOX15	5.08e-05	166	25	4	GO:0005506
GeneOntologyMolecularFunction	epoxide hydrolase activity	ALOX12 ALOX15	8.22e-05	11	25	2	GO:0004301
GeneOntologyMolecularFunction	hydrolase activity, acting on ether bonds	ALOX12 ALOX15	1.16e-04	13	25	2	GO:0016801
GeneOntologyMolecularFunction	ether hydrolase activity	ALOX12 ALOX15	1.16e-04	13	25	2	GO:0016803
GeneOntologyMolecularFunction	dioxygenase activity	ALOX12 ALOX12B ALOX15	2.44e-04	98	25	3	GO:0051213
GeneOntologyMolecularFunction	phosphatidylinositol phosphate binding	ALOX15 ATG2B SNX18	1.91e-03	199	25	3	GO:1901981
GeneOntologyMolecularFunction	oxidoreductase activity	CYP4F3 DHTKD1 ALOX12 ALOX12B ALOX15	2.30e-03	766	25	5	GO:0016491
GeneOntologyMolecularFunction	phosphatidylinositol-4,5-bisphosphate binding	ALOX15 SNX18	6.26e-03	95	25	2	GO:0005546
GeneOntologyMolecularFunction	phosphatidylinositol binding	ALOX15 ATG2B SNX18	6.98e-03	316	25	3	GO:0035091
GeneOntologyMolecularFunction	ribosome binding	RPN2 GCN1	9.82e-03	120	25	2	GO:0043022
GeneOntologyMolecularFunction	phosphatidylinositol bisphosphate binding	ALOX15 SNX18	9.97e-03	121	25	2	GO:1902936
GeneOntologyBiologicalProcess	hepoxilin metabolic process	ALOX12 ALOX12B ALOX15	7.72e-08	8	24	3	GO:0051121
GeneOntologyBiologicalProcess	hepoxilin biosynthetic process	ALOX12 ALOX12B ALOX15	7.72e-08	8	24	3	GO:0051122
GeneOntologyBiologicalProcess	lipoxygenase pathway	ALOX12 ALOX12B ALOX15	2.27e-07	11	24	3	GO:0019372
GeneOntologyBiologicalProcess	arachidonate metabolic process	CYP4F3 ALOX12 ALOX12B ALOX15	1.09e-06	68	24	4	GO:0019369
GeneOntologyBiologicalProcess	fatty acid derivative metabolic process	CYP4F3 PPT2 ALOX12 ALOX15	2.32e-06	82	24	4	GO:1901568
GeneOntologyBiologicalProcess	linoleic acid metabolic process	ALOX12 ALOX12B ALOX15	2.41e-06	23	24	3	GO:0043651
GeneOntologyBiologicalProcess	lipoxin A4 biosynthetic process	ALOX12 ALOX15	3.89e-06	3	24	2	GO:2001303
GeneOntologyBiologicalProcess	long-chain fatty acid biosynthetic process	ALOX12 ALOX12B ALOX15	4.96e-06	29	24	3	GO:0042759
GeneOntologyBiologicalProcess	lipoxin A4 metabolic process	ALOX12 ALOX15	7.77e-06	4	24	2	GO:2001302
GeneOntologyBiologicalProcess	lipoxin biosynthetic process	ALOX12 ALOX15	7.77e-06	4	24	2	GO:2001301
GeneOntologyBiologicalProcess	long-chain fatty acid metabolic process	CYP4F3 ALOX12 ALOX12B ALOX15	1.20e-05	124	24	4	GO:0001676
GeneOntologyBiologicalProcess	lipoxin metabolic process	ALOX12 ALOX15	1.29e-05	5	24	2	GO:2001300
GeneOntologyBiologicalProcess	unsaturated fatty acid metabolic process	CYP4F3 ALOX12 ALOX12B ALOX15	1.37e-05	128	24	4	GO:0033559
GeneOntologyBiologicalProcess	monocarboxylic acid metabolic process	LPGAT1 CYP4F3 DHTKD1 ALOX12 ALOX12B SLC5A6 ALOX15	1.39e-05	731	24	7	GO:0032787
GeneOntologyBiologicalProcess	icosanoid metabolic process	CYP4F3 ALOX12 ALOX12B ALOX15	2.06e-05	142	24	4	GO:0006690
GeneOntologyBiologicalProcess	fatty acid derivative biosynthetic process	PPT2 ALOX12 ALOX15	2.95e-05	52	24	3	GO:1901570
GeneOntologyBiologicalProcess	olefinic compound metabolic process	CYP4F3 ALOX12 ALOX12B ALOX15	5.20e-05	180	24	4	GO:0120254
GeneOntologyBiologicalProcess	fatty acid biosynthetic process	LPGAT1 ALOX12 ALOX12B ALOX15	6.55e-05	191	24	4	GO:0006633
GeneOntologyBiologicalProcess	carboxylic acid metabolic process	LPGAT1 CYP4F3 DHTKD1 ALOX12 ALOX12B SLC5A6 ALOX15	1.28e-04	1035	24	7	GO:0019752
GeneOntologyBiologicalProcess	oxoacid metabolic process	LPGAT1 CYP4F3 DHTKD1 ALOX12 ALOX12B SLC5A6 ALOX15	1.47e-04	1058	24	7	GO:0043436
GeneOntologyBiologicalProcess	organic acid metabolic process	LPGAT1 CYP4F3 DHTKD1 ALOX12 ALOX12B SLC5A6 ALOX15	1.52e-04	1064	24	7	GO:0006082
GeneOntologyBiologicalProcess	fatty acid metabolic process	LPGAT1 CYP4F3 ALOX12 ALOX12B ALOX15	1.63e-04	461	24	5	GO:0006631
GeneOntologyBiologicalProcess	monocarboxylic acid biosynthetic process	LPGAT1 ALOX12 ALOX12B ALOX15	2.15e-04	260	24	4	GO:0072330
GeneOntologyBiologicalProcess	morphogenesis of an endothelium	PRKD2 ALOX12	2.69e-04	21	24	2	GO:0003159
GeneOntologyBiologicalProcess	endothelial tube morphogenesis	PRKD2 ALOX12	2.69e-04	21	24	2	GO:0061154
GeneOntologyBiologicalProcess	lipid biosynthetic process	LPGAT1 PRKD2 PPT2 ALOX12 ALOX12B ALOX15	2.69e-04	813	24	6	GO:0008610
GeneOntologyBiologicalProcess	lipid oxidation	ALOX12 ALOX12B ALOX15	4.39e-04	129	24	3	GO:0034440
GeneOntologyBiologicalProcess	sodium ion import across plasma membrane	SLC9A2 SLC5A6	4.47e-04	27	24	2	GO:0098719
GeneOntologyBiologicalProcess	carboxylic acid biosynthetic process	LPGAT1 ALOX12 ALOX12B ALOX15	8.48e-04	374	24	4	GO:0046394
GeneOntologyBiologicalProcess	organic acid biosynthetic process	LPGAT1 ALOX12 ALOX12B ALOX15	8.74e-04	377	24	4	GO:0016053
GeneOntologyBiologicalProcess	establishment of skin barrier	ALOX12 ALOX12B	1.03e-03	41	24	2	GO:0061436
GeneOntologyBiologicalProcess	leukotriene metabolic process	CYP4F3 ALOX12	1.03e-03	41	24	2	GO:0006691
GeneOntologyBiologicalProcess	lipid modification	ALOX12 ALOX12B ALOX15	1.90e-03	214	24	3	GO:0030258
GeneOntologyBiologicalProcess	unsaturated fatty acid biosynthetic process	ALOX12 ALOX15	1.92e-03	56	24	2	GO:0006636
Domain	LIPOXYGENASE_2	ALOX12 ALOX12B ALOX15	4.78e-08	6	26	3	PS00081
Domain	LipOase	ALOX12 ALOX12B ALOX15	4.78e-08	6	26	3	IPR000907
Domain	LipOase_Fe_BS	ALOX12 ALOX12B ALOX15	4.78e-08	6	26	3	IPR020833
Domain	LipOase_CS	ALOX12 ALOX12B ALOX15	4.78e-08	6	26	3	IPR020834
Domain	LipOase_mml	ALOX12 ALOX12B ALOX15	4.78e-08	6	26	3	IPR001885
Domain	LIPOXYGENASE_1	ALOX12 ALOX12B ALOX15	4.78e-08	6	26	3	PS00711
Domain	LipOase_C	ALOX12 ALOX12B ALOX15	4.78e-08	6	26	3	IPR013819
Domain	Lipoxygenase	ALOX12 ALOX12B ALOX15	4.78e-08	6	26	3	PF00305
Domain	LIPOXYGENASE_3	ALOX12 ALOX12B ALOX15	4.78e-08	6	26	3	PS51393
Domain	LH2	ALOX12 ALOX12B ALOX15	1.93e-06	18	26	3	SM00308
Domain	PLAT	ALOX12 ALOX12B ALOX15	3.13e-06	21	26	3	PF01477
Domain	PLAT	ALOX12 ALOX12B ALOX15	3.13e-06	21	26	3	PS50095
Domain	PLAT/LH2_dom	ALOX12 ALOX12B ALOX15	3.13e-06	21	26	3	IPR001024
Domain	-	ALOX12 ALOX12B ALOX15	3.13e-06	21	26	3	2.60.60.20
Domain	AAA+_ATPase	DYNC1H1 ABCB4	1.70e-02	144	26	2	IPR003593
Domain	AAA	DYNC1H1 ABCB4	1.70e-02	144	26	2	SM00382
Pathway	REACTOME_SYNTHESIS_OF_12_EICOSATETRAENOIC_ACID_DERIVATIVES	ALOX12 ALOX12B ALOX15	1.32e-07	7	23	3	M27139
Pathway	REACTOME_SYNTHESIS_OF_12_EICOSATETRAENOIC_ACID_DERIVATIVES	ALOX12 ALOX12B ALOX15	1.32e-07	7	23	3	MM14860
Pathway	KEGG_ARACHIDONIC_ACID_METABOLISM	CYP4F3 ALOX12 ALOX12B ALOX15	2.15e-06	58	23	4	M5410
Pathway	REACTOME_ARACHIDONIC_ACID_METABOLISM	CYP4F3 ALOX12 ALOX12B ALOX15	2.31e-06	59	23	4	M27140
Pathway	REACTOME_ARACHIDONIC_ACID_METABOLISM	CYP4F3 ALOX12 ALOX12B ALOX15	2.64e-06	61	23	4	MM14861
Pathway	REACTOME_FATTY_ACID_METABOLISM	CYP4F3 PPT2 ALOX12 ALOX12B ALOX15	6.79e-06	170	23	5	MM15573
Pathway	REACTOME_FATTY_ACID_METABOLISM	CYP4F3 PPT2 ALOX12 ALOX12B ALOX15	8.04e-06	176	23	5	M27854
Pathway	REACTOME_METABOLISM_OF_LIPIDS	LPGAT1 PRKD2 CYP4F3 PPT2 ALOX12 ALOX12B ALOX15 ABCB4	1.59e-05	757	23	8	M27451
Pathway	WP_EICOSANOID_METABOLISM_VIA_LIPOXYGENASES_LOX	CYP4F3 ALOX12 ALOX15	2.00e-05	33	23	3	MM15963
Pathway	WP_METABOLISM_OF_ALPHALINOLENIC_ACID	ALOX12 ALOX15	3.80e-05	6	23	2	M39844
Pathway	WP_OCTADECANOID_FORMATION_FROM_LINOLEIC_ACID	ALOX12B ALOX15	1.66e-04	12	23	2	M48064
Pathway	REACTOME_METABOLISM_OF_LIPIDS	LPGAT1 CYP4F3 PPT2 ALOX12 ALOX12B ALOX15	3.75e-04	620	23	6	MM15193
Pathway	REACTOME_BIOSYNTHESIS_OF_SPECIALIZED_PRORESOLVING_MEDIATORS_SPMS	ALOX12 ALOX15	4.28e-04	19	23	2	M27889
Pathway	REACTOME_SYNTHESIS_OF_LEUKOTRIENES_LT_AND_EOXINS_EX	CYP4F3 ALOX15	5.25e-04	21	23	2	M27137
Pathway	WP_EICOSANOID_SYNTHESIS	ALOX12 ALOX15	5.77e-04	22	23	2	MM15961
Pathway	REACTOME_BIOSYNTHESIS_OF_SPECIALIZED_PRORESOLVING_MEDIATORS_SPMS	ALOX12 ALOX15	5.77e-04	22	23	2	MM15614
Pathway	WP_EICOSANOID_SYNTHESIS	ALOX12 ALOX15	6.31e-04	23	23	2	M39382
Pathway	WP_OXYLIPINS_PATHWAYS	ALOX12 ALOX15	6.88e-04	24	23	2	MM17249
Pathway	REACTOME_SYNTHESIS_OF_LEUKOTRIENES_LT_AND_EOXINS_EX	CYP4F3 ALOX15	7.47e-04	25	23	2	MM14858
Pathway	WP_EICOSANOID_METABOLISM_VIA_LIPOOXYGENASES_LOX	ALOX12 ALOX15	1.01e-03	29	23	2	M39858
Pathway	WP_PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM_IN_SENESCENCE_WP5122	ALOX12 ALOX15	1.15e-03	31	23	2	M42531
Pathway	WP_PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM_IN_SENESCENCE_WP5321	ALOX12 ALOX15	1.38e-03	34	23	2	M48061
Pubmed	cDNA cloning of a 8-lipoxygenase and a novel epidermis-type lipoxygenase from phorbol ester-treated mouse skin.	ALOX12 ALOX12B ALOX15	1.67e-09	4	27	3	9518531
Pubmed	Identification of quantitative trait loci that regulate obesity and serum lipid levels in MRL/MpJ x SJL/J inbred mice.	ALOX12 ALOX12B ALOX15	1.46e-08	7	27	3	16254318
Pubmed	12-Lipoxygenase Regulates Cold Adaptation and Glucose Metabolism by Producing the Omega-3 Lipid 12-HEPE from Brown Fat.	ALOX12 ALOX12B ALOX15	1.46e-08	7	27	3	31353262
Pubmed	Polymorphisms in ALOX12, but not ALOX15, are significantly associated with BMD in postmenopausal women.	ALOX12 ALOX15	5.80e-07	2	27	2	17520163
Pubmed	Human ALOX12, but not ALOX15, is associated with BMD in white men and women.	ALOX12 ALOX15	5.80e-07	2	27	2	16598376
Pubmed	Emerging role of 12/15-Lipoxygenase (ALOX15) in human pathologies.	ALOX12 ALOX15	5.80e-07	2	27	2	30472260
Pubmed	Glutathione disulfide induces neural cell death via a 12-lipoxygenase pathway.	ALOX12 ALOX15	5.80e-07	2	27	2	19373248
Pubmed	Expression of 12/15-lipoxygenase attenuates intracellular lipid deposition during in vitro foam cell formation.	ALOX12 ALOX15	5.80e-07	2	27	2	15681297
Pubmed	Platelet-type 12-lipoxygenase deletion provokes a compensatory 12/15-lipoxygenase increase that exacerbates oxidative stress in mouse islet β cells.	ALOX12 ALOX15	5.80e-07	2	27	2	30792307
Pubmed	Reduced dietary omega-6 to omega-3 fatty acid ratio and 12/15-lipoxygenase deficiency are protective against chronic high fat diet-induced steatohepatitis.	ALOX12 ALOX15	5.80e-07	2	27	2	25251155
Pubmed	A role for the mouse 12/15-lipoxygenase pathway in promoting epithelial wound healing and host defense.	ALOX12 ALOX15	5.80e-07	2	27	2	15708862
Pubmed	Amelioration of the Alzheimer's disease phenotype by absence of 12/15-lipoxygenase.	ALOX12 ALOX15	5.80e-07	2	27	2	20570249
Pubmed	Biosynthesis of the Maresin Intermediate, 13S,14S-Epoxy-DHA, by Human 15-Lipoxygenase and 12-Lipoxygenase and Its Regulation through Negative Allosteric Modulators.	ALOX12 ALOX15	5.80e-07	2	27	2	32324389
Pubmed	Role of Src tyrosine kinase in the atherogenic effects of the 12/15-lipoxygenase pathway in vascular smooth muscle cells.	ALOX12 ALOX15	5.80e-07	2	27	2	19095999
Pubmed	Reactive oxygen species and 12/15-lipoxygenase contribute to the antiproliferative capacity of alternatively activated myeloid cells elicited during helminth infection.	ALOX12 ALOX15	5.80e-07	2	27	2	15879104
Pubmed	Differential expression and localization of 12/15 lipoxygenases in adipose tissue in human obese subjects.	ALOX12 ALOX15	5.80e-07	2	27	2	21094135
Pubmed	Enhancement role of host 12/15-lipoxygenase in melanoma progression.	ALOX12 ALOX15	5.80e-07	2	27	2	23664097
Pubmed	Networks of enzymatically oxidized membrane lipids support calcium-dependent coagulation factor binding to maintain hemostasis.	ALOX12 ALOX15	5.80e-07	2	27	2	29184033
Pubmed	Lipoxygenase metabolites are mediators of PTH-dependent human osteoblast growth.	ALOX12 ALOX15	5.80e-07	2	27	2	18187376
Pubmed	EGF stimulates lipoxin A4 synthesis and modulates repair in corneal epithelial cells through ERK and p38 activation.	ALOX12 ALOX15	5.80e-07	2	27	2	21220563
Pubmed	12/15-lipoxygenase expressed in non-epithelial cells causes airway epithelial injury in asthma.	ALOX12 ALOX15	5.80e-07	2	27	2	23528921
Pubmed	Resistance to type 1 diabetes induction in 12-lipoxygenase knockout mice.	ALOX12 ALOX15	5.80e-07	2	27	2	10330425
Pubmed	Hepoxilin A3 (HXA3) synthase deficiency is causative of a novel ichthyosis form.	ALOX12 ALOX12B	5.80e-07	2	27	2	18086569
Pubmed	Reciprocal regulation of 12- and 15-lipoxygenases by UV-irradiation in human keratinocytes.	ALOX12 ALOX15	5.80e-07	2	27	2	18755188
Pubmed	Polymorphisms in the human ALOX12 and ALOX15 genes are associated with peak bone mineral density in Chinese nuclear families.	ALOX12 ALOX15	5.80e-07	2	27	2	22089472
Pubmed	12-Lipoxygenase isoenzymes in mouse skin tumor development.	ALOX12 ALOX15	5.80e-07	2	27	2	7576099
Pubmed	Alox12/15 Deficiency Exacerbates, While Lipoxin A4 Ameliorates Hepatic Inflammation in Murine Alcoholic Hepatitis.	ALOX12 ALOX15	5.80e-07	2	27	2	32760397
Pubmed	Arachidonate 12/15-lipoxygenase-induced inflammation and oxidative stress are involved in the development of diabetic cardiomyopathy.	ALOX12 ALOX15	5.80e-07	2	27	2	25187369
Pubmed	12/15-Lipoxygenase signaling in the endoplasmic reticulum stress response.	ALOX12 ALOX15	5.80e-07	2	27	2	22215650
Pubmed	12/15-lipoxygenase is required for the early onset of high fat diet-induced adipose tissue inflammation and insulin resistance in mice.	ALOX12 ALOX15	5.80e-07	2	27	2	19787041
Pubmed	The 12/15-lipoxygenase as an emerging therapeutic target for Alzheimer's disease.	ALOX12 ALOX15	5.80e-07	2	27	2	25708815
Pubmed	Lipoxygenase-catalyzed transformation of epoxy fatty acids to hydroxy-endoperoxides: a potential P450 and lipoxygenase interaction.	ALOX12 ALOX15	5.80e-07	2	27	2	25293588
Pubmed	Enzymic characterization of epidermis-derived 12-lipoxygenase isoenzymes.	ALOX12 ALOX12B	5.80e-07	2	27	2	11256953
Pubmed	Kinetic investigations of the rate-limiting step in human 12- and 15-lipoxygenase.	ALOX12 ALOX15	5.80e-07	2	27	2	12731864
Pubmed	Isotope sensitive branching and kinetic isotope effects in the reaction of deuterated arachidonic acids with human 12- and 15-lipoxygenases.	ALOX12 ALOX15	5.80e-07	2	27	2	18547056
Pubmed	The 12/15-lipoxygenase pathway counteracts fibroblast activation and experimental fibrosis.	ALOX12 ALOX15	5.80e-07	2	27	2	22267335
Pubmed	Characterization of epidermal 12(S) and 12(R) lipoxygenases.	ALOX12 ALOX12B	5.80e-07	2	27	2	12664578
Pubmed	12-Lipoxygenase-knockout mice are resistant to inflammatory effects of obesity induced by Western diet.	ALOX12 ALOX15	5.80e-07	2	27	2	18780776
Pubmed	Lack of association of ALOX12 and ALOX15 polymorphisms with aspirin-exacerbated respiratory disease in Korean patients.	ALOX12 ALOX15	5.80e-07	2	27	2	19663136
Pubmed	12/15-lipoxygenase counteracts inflammation and tissue damage in arthritis.	ALOX12 ALOX15	5.80e-07	2	27	2	19675173
Pubmed	Mechanistic investigations of human reticulocyte 15- and platelet 12-lipoxygenases with arachidonic acid.	ALOX12 ALOX15	5.80e-07	2	27	2	19469483
Pubmed	Overexpression of 12/15-lipoxygenase increases anxiety behavior in female mice.	ALOX12 ALOX15	5.80e-07	2	27	2	24300237
Pubmed	The evolutionary hypothesis of reaction specificity of mammalian ALOX15 orthologs.	ALOX12 ALOX15	5.80e-07	2	27	2	30237084
Pubmed	12/15-lipoxygenase is increased in Alzheimer's disease: possible involvement in brain oxidative stress.	ALOX12 ALOX15	5.80e-07	2	27	2	15111312
Pubmed	Insulin-like growth factor I reduces lipid oxidation and foam cell formation via downregulation of 12/15-lipoxygenase.	ALOX12 ALOX15	1.74e-06	3	27	2	25549319
Pubmed	Human 5-, 12- and 15-lipoxygenase-1 coexist in kidney but show opposite trends and their balance changes in cancer.	ALOX12 ALOX15	1.74e-06	3	27	2	22825379
Pubmed	Aloxe3 knockout mice reveal a function of epidermal lipoxygenase-3 as hepoxilin synthase and its pivotal role in barrier formation.	ALOX12B ALOX15	1.74e-06	3	27	2	22832496
Pubmed	5-Lipoxygenase, but not 12/15-lipoxygenase, contributes to degeneration of retinal capillaries in a mouse model of diabetic retinopathy.	ALOX12 ALOX15	1.74e-06	3	27	2	18346986
Pubmed	Macrophage 12/15 lipoxygenase expression increases plasma and hepatic lipid levels and exacerbates atherosclerosis.	ALOX12 ALOX15	1.74e-06	3	27	2	22279185
Pubmed	Experimental allergic encephalomyelitis is exacerbated in mice deficient for 12/15-lipoxygenase or 5-lipoxygenase.	ALOX12 ALOX15	1.74e-06	3	27	2	15328042
Pubmed	The molecular biology of mammalian lipoxygenases and the quest for eicosanoid functions using lipoxygenase-deficient mice.	ALOX12 ALOX15	1.74e-06	3	27	2	8944751
Pubmed	Improved survival and reduced vascular permeability by eliminating or blocking 12/15-lipoxygenase in mouse models of acute lung injury (ALI).	ALOX12 ALOX15	1.74e-06	3	27	2	19752233
Pubmed	12/15-lipoxygenase-dependent myeloid production of interleukin-12 is essential for resistance to chronic toxoplasmosis.	ALOX12 ALOX15	1.74e-06	3	27	2	19822654
Pubmed	Smooth muscle-specific expression of calcium-independent phospholipase A2β (iPLA2β) participates in the initiation and early progression of vascular inflammation and neointima formation.	ALOX12 ALOX15	1.74e-06	3	27	2	22637477
Pubmed	Differential contribution of lipoxygenase isozymes to nigrostriatal vulnerability.	ALOX12 ALOX15	1.74e-06	3	27	2	23079635
Pubmed	Transcriptional regulation of β-secretase-1 by 12/15-lipoxygenase results in enhanced amyloidogenesis and cognitive impairments.	ALOX12 ALOX15	1.74e-06	3	27	2	22275252
Pubmed	Role of 12/15-lipoxygenase in the expression of MCP-1 in mouse macrophages.	ALOX12 ALOX15	1.74e-06	3	27	2	18296557
Pubmed	Relationship between 12/15-lipoxygenase and COX-2 in mesangial cells: potential role in diabetic nephropathy.	ALOX12 ALOX15	1.74e-06	3	27	2	16514433
Pubmed	Oxidative metabolism of a fatty acid amide hydrolase-regulated lipid, arachidonoyltaurine.	ALOX12 ALOX15	1.74e-06	3	27	2	18311922
Pubmed	Effects of silencing leukocyte-type 12/15-lipoxygenase using short interfering RNAs.	ALOX12 ALOX15	1.74e-06	3	27	2	15576842
Pubmed	Following experimental stroke, the recovering brain is vulnerable to lipoxygenase-dependent semaphorin signaling.	ALOX12 ALOX15	1.74e-06	3	27	2	23070608
Pubmed	Phospholipid membranes drive abdominal aortic aneurysm development through stimulating coagulation factor activity.	ALOX12 ALOX15	1.74e-06	3	27	2	30944221
Pubmed	5 S,15 S-Dihydroperoxyeicosatetraenoic Acid (5,15-diHpETE) as a Lipoxin Intermediate: Reactivity and Kinetics with Human Leukocyte 5-Lipoxygenase, Platelet 12-Lipoxygenase, and Reticulocyte 15-Lipoxygenase-1.	ALOX12 ALOX15	1.74e-06	3	27	2	30407793
Pubmed	Functional characterization of genetic enzyme variations in human lipoxygenases.	ALOX12 ALOX15	3.48e-06	4	27	2	24282679
Pubmed	Characterization of human 12-lipoxygenase genes.	ALOX12 ALOX15	3.48e-06	4	27	2	1570320
Pubmed	Selective interleukin-12 synthesis defect in 12/15-lipoxygenase-deficient macrophages associated with reduced atherosclerosis in a mouse model of familial hypercholesterolemia.	ALOX12 ALOX15	3.48e-06	4	27	2	12122008
Pubmed	Identification of 12/15-lipoxygenase as a regulator of axon degeneration through high-content screening.	ALOX12 ALOX15	3.48e-06	4	27	2	25698732
Pubmed	cDNA cloning, expression, mutagenesis of C-terminal isoleucine, genomic structure, and chromosomal localizations of murine 12-lipoxygenases.	ALOX12 ALOX15	3.48e-06	4	27	2	8188678
Pubmed	Increased nuclear apoptosis-inducing factor after transient focal ischemia: a 12/15-lipoxygenase-dependent organelle damage pathway.	ALOX12 ALOX15	3.48e-06	4	27	2	20068575
Pubmed	Growth hormone-releasing peptide-2 suppresses vascular oxidative stress in ApoE-/- mice but does not reduce atherosclerosis.	ALOX12 ALOX15	3.48e-06	4	27	2	19819949
Pubmed	Human lipoxygenase pathway gene variation and association with markers of subclinical atherosclerosis in the diabetes heart study.	ALOX12 ALOX15	3.48e-06	4	27	2	20592751
Pubmed	Dual 12/15- and 5-lipoxygenase deficiency in macrophages alters arachidonic acid metabolism and attenuates peritonitis and atherosclerosis in ApoE knock-out mice.	ALOX12 ALOX15	3.48e-06	4	27	2	19509298
Pubmed	Levels of expression of lipoxygenases and cyclooxygenase-2 in human breast cancer.	ALOX12 ALOX15	3.48e-06	4	27	2	12907138
Pubmed	Neonatal imprinting of alveolar macrophages via neutrophil-derived 12-HETE.	ALOX12 ALOX15	5.80e-06	5	27	2	36599368
Pubmed	Increased 12/15-lipoxygenase enhances cell growth, fibronectin deposition, and neointimal formation in response to carotid injury.	ALOX12 ALOX15	5.80e-06	5	27	2	20947825
Pubmed	Platelet 12-LOX is essential for FcγRIIa-mediated platelet activation.	ALOX12 ALOX15	5.80e-06	5	27	2	25100742
Pubmed	mRNA levels of enzymes and receptors implicated in arachidonic acid metabolism in gliomas.	ALOX12 ALOX15	8.69e-06	6	27	2	20382140
Pubmed	Lack of effect of common single nucleotide polymorphisms in leukotriene pathway genes on platelet reactivity in patients with diabetes.	ALOX12 ALOX15	8.69e-06	6	27	2	23828562
Pubmed	Expression of inactive glutathione peroxidase 4 leads to embryonic lethality, and inactivation of the Alox15 gene does not rescue such knock-in mice.	ALOX12 ALOX15	8.69e-06	6	27	2	25313597
Pubmed	Identification of 12-lipoxygenase interaction with cellular proteins by yeast two-hybrid screening.	ALOX12 ALOX12B	1.22e-05	7	27	2	10727209
Pubmed	Class A scavenger receptor-mediated macrophage adhesion requires coupling of calcium-independent phospholipase A(2) and 12/15-lipoxygenase to Rac and Cdc42 activation.	ALOX12 ALOX15	1.22e-05	7	27	2	17873277
Pubmed	Murine 12/15-lipoxygenase regulates ATP-binding cassette transporter G1 protein degradation through p38- and JNK2-dependent pathways.	ALOX12 ALOX15	1.62e-05	8	27	2	19713213
Pubmed	A gene(s) for all-trans-retinoic acid-induced forelimb defects mapped and confirmed to murine chromosome 11.	ALOX12 ALOX15	1.62e-05	8	27	2	15781699
Pubmed	Variation in eicosanoid genes, non-fatal myocardial infarction and ischemic stroke.	ALOX12 ALOX15	1.62e-05	8	27	2	19046748
Pubmed	Oct4 links multiple epigenetic pathways to the pluripotency network.	SSRP1 RPN2 GCN1 DYNC1H1	1.78e-05	203	27	4	22083510
Pubmed	Drafting the CLN3 protein interactome in SH-SY5Y human neuroblastoma cells: a label-free quantitative proteomics approach.	LPGAT1 RPN2 GCN1	2.50e-05	73	27	3	23464991
Pubmed	ISG15 Connects Autophagy and IFN-γ-Dependent Control of Toxoplasma gondii Infection in Human Cells.	SSRP1 GCN1 DYNC1H1 ATG2B	5.26e-05	268	27	4	33024031
Pubmed	Stasimon/Tmem41b localizes to mitochondria-associated ER membranes and is essential for mouse embryonic development.	RPN2 GCN1 SLC5A6	9.23e-05	113	27	3	30352685
Pubmed	The role of group IIF-secreted phospholipase A2 in epidermal homeostasis and hyperplasia.	ALOX12 ALOX15	1.21e-04	21	27	2	26438362
Pubmed	A function for cyclin D1 in DNA repair uncovered by protein interactome analyses in human cancers.	E2F7 GCN1 DYNC1H1	1.24e-04	125	27	3	21654808
Pubmed	Charcot-Marie-Tooth Neuropathy Type 2 – RETIRED CHAPTER, FOR HISTORICAL REFERENCE ONLY	DHTKD1 DYNC1H1	1.45e-04	23	27	2	20301462
Pubmed	Evidence that the transcriptional repressor ICER is regulated via the N-end rule for ubiquitination.	GCN1 DYNC1H1	2.17e-04	28	27	2	35227662
Pubmed	Interactome analysis reveals that lncRNA HULC promotes aerobic glycolysis through LDHA and PKM2.	SSRP1 DYNC1H1 NFKB2	2.62e-04	161	27	3	32572027
Pubmed	Polymorphic variants in hereditary pancreatic cancer genes are not associated with pancreatic cancer risk.	RAD54B FANCA	2.66e-04	31	27	2	19690177
Pubmed	Bcl2L13 is a ceramide synthase inhibitor in glioblastoma.	PPT2 RPN2	2.84e-04	32	27	2	24706805
Pubmed	Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry.	GCN1 DYNC1H1	3.21e-04	34	27	2	11101529
Pubmed	Network organization of the human autophagy system.	SSRP1 RPN2 GCN1 ATG2B	3.43e-04	437	27	4	20562859
Pubmed	AMPK, a Regulator of Metabolism and Autophagy, Is Activated by Lysosomal Damage via a Novel Galectin-Directed Ubiquitin Signal Transduction System.	SSRP1 RPN2 DYNC1H1 SLC5A6	5.04e-04	484	27	4	31995728
Pubmed	Polymorphisms in innate immunity genes and risk of childhood leukemia.	ALOX12 ALOX12B ALOX15	5.39e-04	206	27	3	20438785
Pubmed	Risk of meningioma and common variation in genes related to innate immunity.	ALOX12 ALOX12B ALOX15	5.47e-04	207	27	3	20406964
Interaction	TMEM38B interactions	TACR3 RPN2 ST7 SLC5A6	1.68e-06	68	26	4	int:TMEM38B
Cytoband	2q11.2	SLC9A2 ANKRD36	8.30e-04	72	27	2	2q11.2
Cytoband	Ensembl 112 genes in cytogenetic band chr17p13	ALOX12 ALOX12B ALOX15	1.09e-03	346	27	3	chr17p13
Cytoband	17p13.1	ALOX12 ALOX12B	2.20e-03	118	27	2	17p13.1
GeneFamily	Arachidonate lipoxygenases	ALOX12 ALOX12B ALOX15	1.96e-08	6	19	3	407
GeneFamily	Ankyrin repeat domain containing	ANKRD36 NFKB2	2.63e-02	242	19	2	403
Coexpression	FUJII_YBX1_TARGETS_DN	E2F7 ANKRD36 SSRP1 RAD54B	4.47e-05	194	27	4	M14340
Coexpression	GSE12366_GC_VS_NAIVE_BCELL_DN	PRKD2 ADAM28 ABCB4 SNX18	4.56e-05	195	27	4	M3170
Coexpression	GUTIERREZ_WALDENSTROEMS_MACROGLOBULINEMIA_1_UP	ADAM28 ABCB4	4.57e-05	10	27	2	M13976
Coexpression	GSE1925_CTRL_VS_3H_IFNG_STIM_MACROPHAGE_UP	RPN2 ST7 SLC5A6 NFKB2	5.03e-05	200	27	4	M6305
ToppCell	critical-Epithelial-FOXN4+\|critical / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	E2F7 ANKRD36 SSRP1 ST7 ALOX15	1.17e-07	198	27	5	6b160b3d6a2c1b1641c2c7dcec1a7ef38411fec9
ToppCell	3'_v3-bone_marrow-Mast-Mast_cell_lympho\|bone_marrow / Manually curated celltypes from each tissue	ANKRD36 SND1-IT1 ADAM28 ATG2B	3.23e-06	170	27	4	4dedf482cd4521b3f87d2b5ae80f7a3ea8686a15
ToppCell	368C-Myeloid-Dendritic-cDC_proliferating_1\|368C / Donor, Lineage, Cell class and subclass (all cells)	E2F7 PPT2 GCN1 ABCB4	3.96e-06	179	27	4	ec69e1dd897414033ba5b007aa82655a79adca6c
ToppCell	368C-Myeloid-Dendritic-cDC_proliferating_1\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	E2F7 PPT2 GCN1 ABCB4	4.61e-06	186	27	4	799903b68bc6f6205d004b44c603424b0d5f7c32
ToppCell	Cerebellum-Endothelial-ENDOTHELIAL_STALK-Flt1_1-Endothelial_Stalk.Flt1.Mgp_(Mgp)-\|Cerebellum / BrainAtlas - Mouse McCarroll V32	E2F7 ALOX12 RAD54B	1.71e-05	83	27	3	21d4b74b48a4377e81f1e00bba9c654f2a0d714b
ToppCell	Cerebellum-Endothelial-ENDOTHELIAL_STALK-Flt1_1-Endothelial_Stalk.Flt1.Mgp_(Mgp)\|Cerebellum / BrainAtlas - Mouse McCarroll V32	E2F7 ALOX12 RAD54B	1.71e-05	83	27	3	fd7fd3d781b096dea51a5e5d5f516699f6e7bd57
ToppCell	Cerebellum-Endothelial-ENDOTHELIAL_STALK-Flt1_1-Endothelial_Stalk.Flt1.Mgp_(Mgp)--\|Cerebellum / BrainAtlas - Mouse McCarroll V32	E2F7 ALOX12 RAD54B	1.71e-05	83	27	3	148171cf2cd253e502185848512b7c17096d701f
ToppCell	Thalamus-Endothelial-ENDOTHELIAL_STALK-Flt1_1\|Thalamus / BrainAtlas - Mouse McCarroll V32	SLC9A2 ALOX12 RAD54B	3.88e-05	109	27	3	4e4a884b8979f4ff8b232c1581ea78884dda29ed
ToppCell	Posterior_cortex-Endothelial-ENDOTHELIAL_STALK-Flt1_1\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	E2F7 ALOX12 RAD54B	6.70e-05	131	27	3	d46bb28612b9690b2e3550b8adbd10781788c00d
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell_cycling-Cycling_Connecting_Tubule_Cell_S-high\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	E2F7 SLC9A2 FANCA	7.99e-05	139	27	3	c9bf98bed77415a1438f3f9e441a1346e75c26b0
ToppCell	BAL-Control-Myeloid-cDC-cDC-cDC_4\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	E2F7 ADAM28 ABCB4	8.70e-05	143	27	3	5a279da1cd8e63db32f7c85a73b493c2121d0a96
ToppCell	Cerebellum-Endothelial-ENDOTHELIAL_STALK-Flt1_1\|Cerebellum / BrainAtlas - Mouse McCarroll V32	E2F7 ALOX12 RAD54B	9.06e-05	145	27	3	37580218f6a6f65a1d827cbcf59465f8827f9a55
ToppCell	BAL-Control-Myeloid-cDC-cDC-cDC_4\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	E2F7 ADAM28 ABCB4	9.06e-05	145	27	3	997bd540c43725a85ca97e4b79ebe0d336860287
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell_cycling\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	E2F7 SLC9A2 FANCA	9.63e-05	148	27	3	18cfecd6ae20edb74f5d44ba759909df356acf3a
ToppCell	3'-Airway_Nasal-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-Suprabasal_L.0.0.1.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	E2F7 ALOX12B RAD54B	1.24e-04	161	27	3	2165897924c790fec43502283f1df221c56c1e9f
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	E2F7 RAD54B FANCA	1.28e-04	163	27	3	3f434015c0cbefb31eeda133c34f75384c5f7e22
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell_cycling-Cycling_Connecting_Tubule_Cell_S-high\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	E2F7 RAD54B FANCA	1.38e-04	167	27	3	108ae6221c6edc63c0ec42c42471b3a15a594043
ToppCell	normal_Lung-Fibroblasts-Mesothelial_cells\|Fibroblasts / Location, Cell class and cell subclass	CYP4F3 ALOX12B ALOX15	1.38e-04	167	27	3	892a2dc83ab5de5a1016402f8e95d2aabf651326
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_S-high\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	E2F7 RAD54B FANCA	1.43e-04	169	27	3	121768fc51fc3441ec725346a1bbe29e21d05971
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_S-high\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	E2F7 RAD54B FANCA	1.43e-04	169	27	3	0bc8ef341ce307b19018d4ac8de0a4d04254209d
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell_cycling-Cycling_Distal_Convoluted_Tubule_Cell_S-high\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	E2F7 RAD54B FANCA	1.43e-04	169	27	3	e7514956b2e4298222ec443f98b2f5289451786e
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_G2M\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	E2F7 SSRP1 RAD54B	1.45e-04	170	27	3	21bfe070e63722672176052b386167ea4c3dc4e5
ToppCell	10x5'-Liver-Lymphocytic_B-ABC_aged-B_memory\|Liver / Manually curated celltypes from each tissue	ADAM28 ALOX12B ABCB4	1.48e-04	171	27	3	eb47f4a09a630ed14a0898377039ed50ef7cc292
ToppCell	droplet-Heart-4Chambers-21m-Hematologic-coronary_vascular_endothelial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	E2F7 ALOX12 FANCA	1.48e-04	171	27	3	e852d0e8589eecf4a2e5fea039b52a67c5d58dbd
ToppCell	PND07-Epithelial-Epithelial_Airway-Basal-Basal-Basal_mature\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ADAM28 ALOX12B ALOX15	1.53e-04	173	27	3	1b2508cc890430bd4b2cf232c633928edb86c57e
ToppCell	5'-GW_trimst-1.5-SmallIntestine-Epithelial-neuro-epithelial-K_cells_(GIP+)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CYP4F3 SLC9A2 ALOX12B	1.55e-04	174	27	3	3503c7dec498597f76a86dbd5e4bb2311e743bde
ToppCell	BAL-Control-Myeloid-cDC-cDC-cDC_6\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	ADAM28 NFKB2 ABCB4	1.63e-04	177	27	3	c9e5820ff0bc7ad1adcfb2651713fdfc58bced56
ToppCell	PBMC-Convalescent-Lymphocyte-B-B_cell-B_naive-B_naive-9\|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	DHTKD1 ADAM28 ABCB4	1.63e-04	177	27	3	ae55773c531099a9e94f44f01ba48b5e71dddc53
ToppCell	PND03-Endothelial-Endothelial_blood-vessel-Microvascular_EC-EPC-EPC_prolif\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	E2F7 ABCB4 RAD54B	1.63e-04	177	27	3	8a74f5e72de605774111057bd87a7e7e4a6385cd
ToppCell	BAL-Control-Myeloid-cDC-cDC-cDC_6\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	ADAM28 NFKB2 ABCB4	1.63e-04	177	27	3	3a150dcaefa342d49968b42c7cdb1fbb633adcd0
ToppCell	ICU-NoSEP-Myeloid-cDC1\|ICU-NoSEP / Disease, Lineage and Cell Type	ST7 ADAM28 ALOX15	1.63e-04	177	27	3	33cd2c183ee8b597012efcbcae72131ac6beaf4e
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_S-high\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	E2F7 RAD54B FANCA	1.69e-04	179	27	3	88d44b04eb5c079531db663ed98ddb20b60feb9a
ToppCell	3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.0.5\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CYP4F3 B4GALNT3 ADAM28	1.69e-04	179	27	3	6e965e424eebef50f0202cff75f458be395cfca1
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_S-high\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	E2F7 RAD54B FANCA	1.69e-04	179	27	3	80112c686a8f85ad5e3cda6e3f3d3d51cf688092
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell_cycling\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	E2F7 RAD54B FANCA	1.72e-04	180	27	3	401df9cddcbca1eb8f0d2687bcacd98e95dc1493
ToppCell	BAL-Severe-Lymphocyte-B-B_cell\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	DHTKD1 ADAM28 ABCB4	1.72e-04	180	27	3	c3c72531af5b9f7a7416727fe609dab5180e03b6
ToppCell	BAL-Severe-Lymphocyte-B-B_cell-B_cell-B_activate-7\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	DHTKD1 ADAM28 ABCB4	1.72e-04	180	27	3	9f4bbaf6435c23e3e552ae22be8ea7884314192d
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	E2F7 RAD54B FANCA	1.72e-04	180	27	3	f8a15c13d85c1bbbf86ce49bb6f86c368ddf22df
ToppCell	BAL-Severe-Lymphocyte-B-B_cell-B_cell\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	DHTKD1 ADAM28 ABCB4	1.72e-04	180	27	3	b465f2f8b0e9a2034a4f1272bb00c77439164dbf
ToppCell	3'-Adult-LargeIntestine-Epithelial-Tuft-related-Microfold_cell\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ALOX12B SLC5A6 NFKB2	1.77e-04	182	27	3	b4f347fb684f6840c166d7473f3f56389f69c14b
ToppCell	Striatum-Macroglia-POLYDENDROCYTE-P5\|Striatum / BrainAtlas - Mouse McCarroll V32	E2F7 SSRP1 FANCA	1.80e-04	183	27	3	f20b0d71f857ac35868fd80531050ad8b6091716
ToppCell	3'-Broncho-tracheal-Immune_Lymphocytic-Lymphocytic_B-B_cell-B_cells\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ADAM28 NFKB2 ABCB4	1.89e-04	186	27	3	1a1e5d85a5ad90afee234c12a9b54a5e93a8a2f2
ToppCell	3'-Broncho-tracheal-Immune_Lymphocytic-Lymphocytic_B-B_cell\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ADAM28 NFKB2 ABCB4	1.89e-04	186	27	3	f1366638edaecad5cad6367440f4c693513bed7e
ToppCell	facs-Skin-Telogen-3m-Epithelial-actively_dividing_stem_cell\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	E2F7 RAD54B FANCA	1.89e-04	186	27	3	9feef5936985e936b3d88f9d1bb012abb6468570
ToppCell	368C-Myeloid-Dendritic-cDC_proliferating_1\|Dendritic / Donor, Lineage, Cell class and subclass (all cells)	E2F7 PPT2 GCN1	1.89e-04	186	27	3	5cadab3271fce9ab6da3d7ba9827b8a221cac166
ToppCell	droplet-Tongue-nan-24m-Epithelial-parabasal\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ALOX12 ADAM28 ALOX12B	1.89e-04	186	27	3	18c06041c6c8a0ebac17b3c8aaebd67e652d315a
ToppCell	facs-Skin-Telogen-3m-Epithelial-keratinocyte_stem_cell\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	E2F7 RAD54B FANCA	1.89e-04	186	27	3	89f5b06bc56674af304912d481ac697c7c870904
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Cycling_Myofibroblast-\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	E2F7 RAD54B FANCA	1.92e-04	187	27	3	e41e39fd3791acf8ae5376cc5061e196d96868ae
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Cycling_Myofibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	E2F7 RAD54B FANCA	1.92e-04	187	27	3	cefa211ef224e803ea9467882e2ca74d0b1492f1
ToppCell	PBMC-Severe-Lymphocyte-B-B_cell-B_naive-B_activate-7\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	ADAM28 NFKB2 ABCB4	1.98e-04	189	27	3	ef33cc03728a78423ee92d2ef1ffed4918d4221f
ToppCell	PBMC-Severe-Myeloid-Neutrophil-Neutrophil-Neu_4\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	CYP4F3 SND1-IT1 ATG2B	2.01e-04	190	27	3	3f0c7d130f66faea778fe567604edf1b4cdf85b3
ToppCell	PBMC-Severe-Lymphocyte-B-B_cell-B_intermediate-B_intermediate-0\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	ADAM28 NFKB2 ABCB4	2.04e-04	191	27	3	b7d17d3ba488378b30f3732f8109f4a7c1673e61
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_B-B_cell\|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)	ADAM28 NFKB2 ABCB4	2.08e-04	192	27	3	446c61c0d6ba89c619efe87ee495951299953981
ToppCell	PBMC_fresh-frozen-Severe-critical_convalescent_d14-21-Lymphocytic-Lymphocytic_B-B_cell-B_c03-CD27-AIM2\|Severe-critical_convalescent_d14-21 / Compartment, severity and other cell annotations on 10x 3' data (130k)	ADAM28 NFKB2 ABCB4	2.08e-04	192	27	3	ab7420aeb22620d85c60b33cf372e5168e538cd4
ToppCell	PBMC-Severe-Myeloid-Neutrophil-Neutrophil-Neu_4\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	CYP4F3 SND1-IT1 ATG2B	2.08e-04	192	27	3	c09dcc73ff9c3855a0f3d7bfa0d5c99c09a117f2
ToppCell	356C-Epithelial_cells-Epithelial-H_(AT1)-\|356C / Donor, Lineage, Cell class and subclass (all cells)	DHTKD1 GCN1 ST7	2.14e-04	194	27	3	4c40d6b50675eae52c419d69e719a9223df02ae3
ToppCell	356C-Epithelial_cells-Epithelial-H_(AT1)\|356C / Donor, Lineage, Cell class and subclass (all cells)	DHTKD1 GCN1 ST7	2.14e-04	194	27	3	99a90de637e3babec2131cdd9f05ea965d8a8f30
ToppCell	moderate-Epithelial-FOXN4+\|moderate / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	E2F7 ANKRD36 SSRP1	2.14e-04	194	27	3	5dffa578149104dda33774361e9e77b227b5f1ce
ToppCell	moderate-Epithelial-FOXN4+\|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	E2F7 ANKRD36 SSRP1	2.14e-04	194	27	3	dff3fb10372053951d41e0ccd41aac3ece6009bd
ToppCell	3'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(nasal)-Club_(nasal)_L.0.2.1.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CYP4F3 ADAM28 ALOX15	2.17e-04	195	27	3	b9a1c5836eb0ca92df788c3ee093b0d9ec7b8ad9
ToppCell	PCW_05-06-Mesenchymal-Mesenchymal_cycling-mes_proliferating1_(3)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	E2F7 RAD54B FANCA	2.17e-04	195	27	3	56d8734d020b3da08a5aa9e67999706a9e023a99
ToppCell	PCW_07-8.5-Mesenchymal-Mesenchymal_cycling-mes_proliferating1_(3)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	E2F7 RAD54B FANCA	2.17e-04	195	27	3	b65463a804fed2d9a3be9e528ca8b9c98469bc86
ToppCell	BAL-Control-Myeloid-cDC-cDC\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	ADAM28 NFKB2 ABCB4	2.24e-04	197	27	3	6f83fc049f38f3de6bc5180ad4b51ceb4d5dcdb6
ToppCell	3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(nasal)-Club_(nasal)_L.0.2.1.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CYP4F3 ADAM28 ALOX15	2.24e-04	197	27	3	ec08a971e8dd9ad69359896c60ad77ff8af08fd0
ToppCell	Control-Myeloid-cDC\|Control / Disease group,lineage and cell class （2021.01.30）	ADAM28 NFKB2 ABCB4	2.24e-04	197	27	3	aef933107da42a763b35041c90950db07707c0cb
ToppCell	BAL-Control-Myeloid-cDC-cDC\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	ADAM28 NFKB2 ABCB4	2.24e-04	197	27	3	15e683f4a610aad3e06723747c8e56ca25f57414
ToppCell	BAL-Control-Myeloid-cDC\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	ADAM28 NFKB2 ABCB4	2.24e-04	197	27	3	6ac50c02899531a25885749d5305da788dfa9dbc
ToppCell	BAL-Control-Myeloid-cDC\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	ADAM28 NFKB2 ABCB4	2.24e-04	197	27	3	513ada82bbbb6a624d89edaa54f8c4a303dfb5e7
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-Suprabasal_L.0.0.1.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CYP4F3 ADAM28 ALOX15	2.27e-04	198	27	3	9718f4c013c347f1b3c785ae232dd2fb6c1fe298
ToppCell	3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(nasal)\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CYP4F3 ADAM28 ALOX15	2.27e-04	198	27	3	3cc9e671f596ef0829684018e4257571fefb6267
ToppCell	cellseq-Epithelial-Epithelial_Airway-Basal/Suprabasal-Suprabasal\|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	CYP4F3 ADAM28 ALOX15	2.27e-04	198	27	3	6e047de63ef59dcb47e4fc06b173b2a02fdcf4c9
ToppCell	Tracheal-NucSeq-Epithelial-Epi_airway_basal-Dividing_Basal\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	E2F7 RAD54B FANCA	2.27e-04	198	27	3	f088badb90c6c2d916195f5649eda102119c9ac6
ToppCell	3'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(nasal)-Club_(nasal)_L.0.2.1.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CYP4F3 ADAM28 ALOX15	2.27e-04	198	27	3	58f5b5e756ab4aa7234aa8d95fba564d6e8c22d9
ToppCell	Tracheal-NucSeq-Epithelial-Epi_airway_basal-Suprabasal\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	CYP4F3 ADAM28 ALOX15	2.27e-04	198	27	3	19d8ff3a4f911b13ecc34844202925475ad4d2ab
ToppCell	Bronchial-NucSeq-Epithelial-Epi_airway_basal-Suprabasal\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	CYP4F3 ADAM28 ALOX15	2.31e-04	199	27	3	f5c3561744e2a0e7716657cb521acb1d8f054b41
ToppCell	critical-Epithelial-FOXN4+\|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	E2F7 SSRP1 ST7	2.34e-04	200	27	3	f39db4250ce220a3eb58edee3f7fc3671701d46f
ToppCell	MS-IIF-Lymphocyte-T/NK-T/NK_proliferative\|IIF / Disease, condition lineage and cell class	E2F7 SSRP1 FANCA	2.34e-04	200	27	3	c7c1806a1054b2b034a26a18aac93fc3bec4dbc8
ToppCell	Parenchymal-NucSeq-Epithelial-Epi_alveolar-Dividing_AT2\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	E2F7 RAD54B FANCA	2.34e-04	200	27	3	af3dc76b4507bf4edd265169f5dfbbb8a19eb394
ToppCell	Influenza-Influenza_Severe-Myeloid-cDC\|Influenza_Severe / Disease, condition lineage and cell class	ST7 ADAM28 RAD54B	2.34e-04	200	27	3	b8415a68ad6f4fea562236a1b0da0dc376d874fb
ToppCell	Posterior_cortex-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Tshz2-Excitatory_Neuron.Slc17a7-Slc17a6.Tshz2-Npnt_(Retrosplenial_areas,_layer_5,_Npnt+)\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	B4GALNT3 ADAM28	2.80e-04	41	27	2	b1e70962de91a747ec718a3fad4247fd0cb7d9a8
ToppCell	Posterior_cortex-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Tshz2-Excitatory_Neuron.Slc17a7-Slc17a6.Tshz2-Npnt_(Retrosplenial_areas,_layer_5,_Npnt+)-\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	B4GALNT3 ADAM28	2.80e-04	41	27	2	16dbb13baa47c4db80ddd83ac36aad6c43b5461a
ToppCell	Globus_pallidus-Endothelial-ENDOTHELIAL_STALK-Flt1_1-Endothelial_Stalk.Flt1.Cdkn1c_(Cdkn1c)\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	ALOX12 RAD54B	4.87e-04	54	27	2	69f66fe78fd59c44b6ca6b565df0ea8e035121e1
ToppCell	Globus_pallidus-Endothelial-ENDOTHELIAL_STALK-Flt1_1-Endothelial_Stalk.Flt1.Cdkn1c_(Cdkn1c)-\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	ALOX12 RAD54B	4.87e-04	54	27	2	75dd172b298d3fb81f3e0c82f593772cb3487b62
ToppCell	Globus_pallidus-Endothelial-ENDOTHELIAL_STALK-Flt1_1-Endothelial_Stalk.Flt1.Cdkn1c_(Cdkn1c)--\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	ALOX12 RAD54B	4.87e-04	54	27	2	67cc62761906a29e9f7beb03b74f600e516c47f1
ToppCell	Thalamus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2.Ttn_(Neuron.Gad1Gad2.Ttn)--\|Thalamus / BrainAtlas - Mouse McCarroll V32	ALOX12B FANCA	5.24e-04	56	27	2	0c137f6263626df9837e5c00fa6ba6201bfebf52
ToppCell	Thalamus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2.Ttn_(Neuron.Gad1Gad2.Ttn)\|Thalamus / BrainAtlas - Mouse McCarroll V32	ALOX12B FANCA	5.24e-04	56	27	2	cc072782b296e75e1bb11e62d280ca199b73481e
ToppCell	Thalamus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2.Ttn_(Neuron.Gad1Gad2.Ttn)-\|Thalamus / BrainAtlas - Mouse McCarroll V32	ALOX12B FANCA	5.24e-04	56	27	2	435fdc82c2c078e5f37a60de36ce80ca0c3aade8
ToppCell	Frontal_cortex-Neuronal-Inhibitory-iN2(Gad1Gad2)-Synpr-Inhibitory_Neuron.Gad1Gad2.Synpr-Pcdh11x_(Neuron.Gad1Gad2.Synpr-Pcdh11x)\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	B4GALNT3 FANCA	5.81e-04	59	27	2	439a9d56eeecccd70a4defb430e228329655cb80
ToppCell	Frontal_cortex-Neuronal-Inhibitory-iN2(Gad1Gad2)-Synpr-Inhibitory_Neuron.Gad1Gad2.Synpr-Pcdh11x_(Neuron.Gad1Gad2.Synpr-Pcdh11x)-\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	B4GALNT3 FANCA	5.81e-04	59	27	2	50432c7b52fd197e8856ba0296c34cf66a2faaf5
ToppCell	Frontal_cortex-Endothelial-ENDOTHELIAL_STALK-Flt1_1-Endothelial_Stalk.Flt1.Gkn3_(Gkn3)-\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	ALOX12 RAD54B	7.05e-04	65	27	2	8f7eac868f1605830cc97d9d1676f3ebff47d49b
ToppCell	Frontal_cortex-Endothelial-ENDOTHELIAL_STALK-Flt1_1-Endothelial_Stalk.Flt1.Gkn3_(Gkn3)--\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	ALOX12 RAD54B	7.05e-04	65	27	2	350f33bcc5924d7e3c3318391d33a984763fe206
ToppCell	Frontal_cortex-Endothelial-ENDOTHELIAL_STALK-Flt1_1-Endothelial_Stalk.Flt1.Gkn3_(Gkn3)\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	ALOX12 RAD54B	7.05e-04	65	27	2	c736a773a1b9cb16b51849a3bf0ccd9aeec7b342
ToppCell	Thalamus-Endothelial-ENDOTHELIAL_STALK-Flt1_1-Endothelial_Stalk.Flt1.Gkn3_(Gkn3)-\|Thalamus / BrainAtlas - Mouse McCarroll V32	ALOX12 RAD54B	9.87e-04	77	27	2	22e8c486ad82773b1facd8dd55ed3f448612c600
ToppCell	Thalamus-Endothelial-ENDOTHELIAL_STALK-Flt1_1-Endothelial_Stalk.Flt1.Gkn3_(Gkn3)--\|Thalamus / BrainAtlas - Mouse McCarroll V32	ALOX12 RAD54B	9.87e-04	77	27	2	9743d4a79c8694f76ab780b9e52b4c6ac1af33ed
ToppCell	Thalamus-Endothelial-ENDOTHELIAL_STALK-Flt1_1-Endothelial_Stalk.Flt1.Gkn3_(Gkn3)\|Thalamus / BrainAtlas - Mouse McCarroll V32	ALOX12 RAD54B	9.87e-04	77	27	2	7e30a46aa68a9374c4c99385a383e0865ff45b1c
ToppCell	Globus_pallidus-Endothelial-ENDOTHELIAL_STALK-Flt1_1-Endothelial_Stalk.Flt1.Apold1_(Pi16)\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	ALOX12 RAD54B	1.06e-03	80	27	2	8713818f57f40c07268f791b45c8af6d522c628f
ToppCell	Globus_pallidus-Endothelial-ENDOTHELIAL_STALK-Flt1_1-Endothelial_Stalk.Flt1.Apold1_(Pi16)-\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	ALOX12 RAD54B	1.06e-03	80	27	2	09baf1f1a4f07369af3696bc15d0ffcf89de984e
ToppCell	Globus_pallidus-Endothelial-ENDOTHELIAL_STALK-Flt1_1-Endothelial_Stalk.Flt1.Apold1_(Pi16)--\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	ALOX12 RAD54B	1.06e-03	80	27	2	475e1595528aef08799f099d7dc54412eaa14742
ToppCell	Hippocampus-Neuronal-Excitatory-eN1(Slc17a7)-eN1_1-Fibcd1-Excitatory_Neuron.Slc17a7.Fibcd1-Lypd1_(CA1_Principal_cells_(Anterior))\|Hippocampus / BrainAtlas - Mouse McCarroll V32	SLC9A2 ALOX12B	1.17e-03	84	27	2	52d167614afa9b056f2934142d3250fe5e70e806
ToppCell	Posterior_cortex-Endothelial-ENDOTHELIAL_STALK-Flt1_1-Endothelial_Stalk.Flt1.Gm9946_(Gm9946)\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	ALOX12 RAD54B	1.17e-03	84	27	2	7da70a68b28fc0414ac3ac7dcd6f6edb56a5e76d
Computational	Genes in the cancer module 326.	CYP4F3 ALOX15	2.28e-04	13	19	2	MODULE_326
Computational	Genes in the cancer module 148.	CYP4F3 ALOX15	2.28e-04	13	19	2	MODULE_148
Computational	Eicosanoid metabolism (and related carboxylic acid biosynthesis).	CYP4F3 ALOX15	3.07e-04	15	19	2	MODULE_462
Computational	Genes in the cancer module 7.	PPT2 ALOX12 ALOX12B ALOX15	7.10e-04	239	19	4	MODULE_7
Drug	artonin E	ALOX12 ALOX12B ALOX15	1.48e-08	5	27	3	CID005481962
Drug	14-hydroxydocosahexaenoic acid	ALOX12 ALOX12B ALOX15	1.48e-08	5	27	3	CID006439735
Drug	20-hydroxyleukotriene B4	CYP4F3 ALOX12 ALOX12B ALOX15	2.30e-08	26	27	4	CID000001589
Drug	1-oleoyl-2-DHA-PC	ALOX12 ALOX12B ALOX15	2.97e-08	6	27	3	CID006438829
Drug	CPHU	ALOX12 ALOX12B ALOX15	2.97e-08	6	27	3	CID000124471
Drug	isamoxole	ALOX12 ALOX12B ALOX15	2.97e-08	6	27	3	CID000042118
Drug	BW A797C	ALOX12 ALOX12B ALOX15	2.97e-08	6	27	3	CID006439067
Drug	dicranin	ALOX12 ALOX12B ALOX15	5.19e-08	7	27	3	CID006441084
Drug	12-IODE	ALOX12 ALOX12B ALOX15	5.19e-08	7	27	3	CID006450050
Drug	lupenone	ALOX12 ALOX12B ALOX15	5.19e-08	7	27	3	CID000092158
Drug	luminol	PPT2 ALOX12 ADAM28 ALOX12B ALOX15	5.48e-08	87	27	5	CID000010638
Drug	colneleic acid	ALOX12 ALOX12B ALOX15	8.30e-08	8	27	3	CID006441681
Drug	CDNQ	ALOX12 ALOX12B ALOX15	8.30e-08	8	27	3	CID000126468
Drug	Cgs 22745	ALOX12 ALOX12B ALOX15	8.30e-08	8	27	3	CID006439321
Drug	htyA	ALOX12 ALOX12B ALOX15	8.30e-08	8	27	3	CID000152267
Drug	sIL-4R	ALOX12 ALOX12B ALOX15 NFKB2	1.01e-07	37	27	4	CID000059757
Drug	p-bromophenacyl bromide	PRKD2 ALOX12 ALOX12B ALOX15 NFKB2	1.22e-07	102	27	5	CID000007454
Drug	14,15-leukotriene A4	ALOX12 ALOX12B ALOX15	1.24e-07	9	27	3	CID006439604
Drug	ODYA	ALOX12 ALOX12B ALOX15	1.24e-07	9	27	3	CID000001931
Drug	octadeca-9,12-dien-1-ol	ALOX12 ALOX12B ALOX15	1.24e-07	9	27	3	CID000068168
Drug	U-56467	ALOX12 ALOX12B ALOX15	1.24e-07	9	27	3	CID006439532
Drug	8,15-diHPETE	ALOX12 ALOX12B ALOX15	1.24e-07	9	27	3	CID005283181
Drug	13-hydroxylinoleic acid	ALOX12 ALOX12B ALOX15	1.24e-07	9	27	3	CID006438633
Drug	A-78773	ALOX12 ALOX12B ALOX15	1.24e-07	9	27	3	CID000071460
Drug	AC1NSXHC	ALOX12 ALOX12B ALOX15	1.24e-07	9	27	3	CID005371969
Drug	U-66,855	ALOX12 ALOX12B ALOX15	1.24e-07	9	27	3	CID000127235
Drug	20-HETE	PRKD2 CYP4F3 ALOX12 ALOX12B ALOX15	1.48e-07	106	27	5	CID005283157
Drug	9-HPODE	ALOX12 ALOX12B ALOX15	1.77e-07	10	27	3	CID000001928
Drug	1,4-pentadiene	ALOX12 ALOX12B ALOX15	1.77e-07	10	27	3	CID000011587
Drug	BW A137C	ALOX12 ALOX12B ALOX15	2.44e-07	11	27	3	CID000129265
Drug	acetone phenylhydrazone	ALOX12 ALOX12B ALOX15	2.44e-07	11	27	3	CID000066026
Drug	Ity A	ALOX12 ALOX12B ALOX15	2.44e-07	11	27	3	CID000188274
Drug	12-KETE	ALOX12 ALOX12B ALOX15	3.25e-07	12	27	3	CID005283162
Drug	nonenal	ALOX12 ALOX12B ALOX15	3.25e-07	12	27	3	CID003015503
Drug	9-HETE	ALOX12 ALOX12B ALOX15	4.22e-07	13	27	3	CID000001926
Drug	AC1NR1Q2	ALOX12 ALOX12B ALOX15	4.22e-07	13	27	3	CID005283190
Drug	hypolaetin	ALOX12 ALOX12B ALOX15	4.22e-07	13	27	3	CID005281648
Drug	AC1L1BGZ	ALOX12 ALOX12B ALOX15	4.22e-07	13	27	3	CID000001435
Drug	ICI207968	ALOX12 ALOX12B ALOX15	4.22e-07	13	27	3	CID000129095
Drug	AC1O4E1A	ALOX12 ALOX12B ALOX15	4.22e-07	13	27	3	CID006365736
Drug	calphostin C	PRKD2 SLC9A2 TACR3 ALOX12 ALOX12B ALOX15 NFKB2	5.31e-07	431	27	7	CID000002533
Drug	oxphaman	ALOX12 ALOX12B ALOX15	5.37e-07	14	27	3	CID005464022
Drug	AC1NR1LB	ALOX12 ALOX12B ALOX15	5.37e-07	14	27	3	CID005283131
Drug	timegadine	ALOX12 ALOX12B ALOX15	5.37e-07	14	27	3	CID000068902
Drug	5-HEPE	ALOX12 ALOX12B ALOX15	5.37e-07	14	27	3	CID000001766
Drug	17-HdoHE	ALOX12 ALOX12B ALOX15	5.37e-07	14	27	3	CID006439179
Drug	AC1MUNZL	CYP4F3 ALOX12 ALOX12B ALOX15	5.52e-07	56	27	4	CID003643892
Drug	ketotifen	ALOX12 ADAM28 ALOX12B ALOX15	5.93e-07	57	27	4	CID000003827
Drug	butylated hydroxytoluene	PRKD2 ALOX12 ALOX12B ALOX15 NFKB2	6.58e-07	143	27	5	CID000031404
Drug	8(S),15(S)-diHETE	ALOX12 ALOX12B ALOX15	6.70e-07	15	27	3	CID000001897
Drug	8R-HpETE	ALOX12 ALOX12B ALOX15	6.70e-07	15	27	3	CID005283170
Drug	Hex-3-enyl acetate	ALOX12 ALOX12B ALOX15	6.70e-07	15	27	3	CID000015574
Drug	13-HpOTrE	ALOX12 ALOX12B ALOX15	6.70e-07	15	27	3	CID005282866
Drug	AC1L1FO5	ALOX12 ALOX12B ALOX15	6.70e-07	15	27	3	CID000003322
Drug	17-ODYA	CYP4F3 ALOX12 ALOX12B ALOX15	7.31e-07	60	27	4	CID000001449
Drug	hex-3-enal	ALOX12 ALOX12B ALOX15	8.24e-07	16	27	3	CID000023234
Drug	sinensetin	ALOX12 ALOX12B ALOX15	8.24e-07	16	27	3	CID000145659
Drug	AC1NR1M2	ALOX12 ALOX12B ALOX15	8.24e-07	16	27	3	CID005283140
Drug	12R-HETrE	ALOX12 ALOX12B ALOX15	8.24e-07	16	27	3	CID005283149
Drug	peroxylinolenic acid	ALOX12 ALOX12B ALOX15	8.24e-07	16	27	3	CID006439905
Drug	compound 48/80	PRKD2 TACR3 ALOX12 ALOX12B ALOX15	8.62e-07	151	27	5	CID000104735
Drug	5,15-diHETE	ALOX12 ALOX12B ALOX15	1.00e-06	17	27	3	CID005283158
Drug	cirsiliol	ALOX12 ALOX12B ALOX15	1.00e-06	17	27	3	CID000160237
Drug	FPL 57231	ALOX12 ALOX12B ALOX15	1.20e-06	18	27	3	CID000122212
Drug	3-nonenal	ALOX12 ALOX12B ALOX15	1.20e-06	18	27	3	CID005283336
Drug	BW540C	ALOX12 ALOX12B ALOX15	1.20e-06	18	27	3	CID000134372
Drug	AC1O5PL5	ALOX12 ALOX12B ALOX15	1.20e-06	18	27	3	CID006438380
Drug	AC1L1H7H	PRKD2 ALOX12 ALOX12B ALOX15	1.21e-06	68	27	4	CID000004009
Drug	1-acetyl-sn-glycero-3-phosphocholine	LPGAT1 PRKD2 ALOX12 ALOX12B ALOX15 NFKB2	1.28e-06	305	27	6	CID005311264
Drug	mamegakinone	ALOX12 ALOX12B	1.35e-06	2	27	2	CID000167673
Drug	AC1LC8RY	ALOX12 ALOX12B	1.35e-06	2	27	2	CID000596379
Drug	AC1NSZ1A	ALOX12 ALOX12B	1.35e-06	2	27	2	CID005320076
Drug	methyl 4-O-feruloyl-5-O-caffeoylquinate	ALOX12 ALOX12B	1.35e-06	2	27	2	CID000637085
Drug	ONO-RS-082	PRKD2 ALOX12 ALOX12B ALOX15	1.36e-06	70	27	4	CID006438389
Drug	antipsoriatic	ALOX12 ALOX12B ALOX15 NFKB2	1.44e-06	71	27	4	CID000005585
Drug	L-651,392	ALOX12 ALOX12B ALOX15	1.67e-06	20	27	3	CID000122182
Drug	TMK777	ALOX12 ALOX12B ALOX15	1.67e-06	20	27	3	CID006438911
Drug	AC1L2P35	ALOX12 ALOX12B ALOX15	1.67e-06	20	27	3	CID000125736
Drug	azelastine	ALOX12 ALOX12B ALOX15 NFKB2	1.70e-06	74	27	4	CID000002267
Drug	AC1O5S1P	ALOX12 ALOX12B ALOX15	1.95e-06	21	27	3	CID006439617
Drug	AC1NRAUB	ALOX12 ALOX12B ALOX15	1.95e-06	21	27	3	CID005288098
Drug	20-carboxyleukotriene B4	ALOX12 ALOX12B ALOX15	1.95e-06	21	27	3	CID000001588
Drug	6,9,12-octadecatrienoic acid	PRKD2 ALOX12 ALOX12B ALOX15	2.11e-06	78	27	4	CID000003453
Drug	5,8,11-eicosatrienoic acid	ALOX12 ALOX12B ALOX15	2.26e-06	22	27	3	CID000004028
Drug	CGS 8515	ALOX12 ALOX12B ALOX15	2.26e-06	22	27	3	CID000163944
Drug	diethylcarbamazine	ALOX12 ALOX12B ALOX15	2.26e-06	22	27	3	CID000003052
Drug	BM 13.177	ALOX12 ALOX12B ALOX15	2.26e-06	22	27	3	CID000051550
Drug	L-656,224	ALOX12 ALOX12B ALOX15	2.59e-06	23	27	3	CID000128132
Drug	AC1NSYHD	ALOX12 ALOX12B ALOX15	2.59e-06	23	27	3	CID005319705
Drug	octadecadienoic acid	ALOX12 ALOX12B ALOX15	2.59e-06	23	27	3	CID005312457
Drug	N-benzyl-N-hydroxy-5-phenylpentamide	ALOX12 ALOX12B ALOX15	2.59e-06	23	27	3	CID000157806
Drug	capsazepine	TACR3 ALOX12 ALOX12B ALOX15	2.84e-06	84	27	4	CID002733484
Drug	AC1L3RSZ	ALOX12 ALOX12B ALOX15	2.96e-06	24	27	3	CID000094238
Drug	hinokitiol	ALOX12 ALOX12B ALOX15	3.36e-06	25	27	3	CID000003611
Drug	13-hydroperoxylinoleic acid	ALOX12 ALOX12B ALOX15	3.36e-06	25	27	3	CID006438144
Drug	pinolenic acid	ALOX12 ALOX12B ALOX15	3.36e-06	25	27	3	CID005312493
Drug	AC1L3X17	ALOX12 ALOX12B ALOX15	3.36e-06	25	27	3	CID000123644
Drug	eicosa-8,11,14-trienoic acid	PRKD2 ALOX12 ALOX12B ALOX15	3.42e-06	88	27	4	CID000003011
Drug	kinin 9	PRKD2 TACR3 ALOX12 ALOX12B ALOX15 NFKB2	3.51e-06	363	27	6	CID000006026
Drug	8-HETE	ALOX12 ALOX12B ALOX15	3.80e-06	26	27	3	CID000001898
Disease	aminoadipic acid measurement	TACR3 DHTKD1	8.91e-04	50	26	2	EFO_0010459
Disease	Microcephaly	DYNC1H1 SLC5A6	1.59e-03	67	26	2	C0025958

Protein segments in the cluster

Peptide	Gene	Start	Entry
KKYEVVYPIRLHPLH	ADAM28	26	Q9UKQ2
YRVPLIPKSHLRHVL	B4GALNT3	331	Q6L9W6
YPIKPYHLKRIHRAV	ANKRD36	26	A6QL64
VVHPTTPAQYFHLLR	DHTKD1	736	Q96HY7
KAPLHFPIPVIRYVV	ATG2B	1536	Q96BY7
VVIDPYLVYHLRPHQ	RAD54B	286	Q9Y620
KPTVTHVHYRIFPIK	LPGAT1	276	Q92604
HVHYRIFPIKDVPLE	LPGAT1	281	Q92604
VKVPHTFLIHSYTRP	PRKD2	261	Q9BZL6
SIHPIFKLIIPHLRY	ALOX15	381	P16050
KLFEPYVVHVLPHLL	GCN1	1451	Q92616
GLHPIFKFLIPHIRY	ALOX12	381	P18054
HPFIETLPHKYETRV	ABCB4	1161	P21439
PHRASYKPVIVVHGL	PPT2	31	Q9UMR5
PVYVGHPVSVVKLHQ	E2F7	841	Q96AV8
VPFESPRYLQVHILH	FANCA	481	O15360
HPLYKLLIPHTRYTV	ALOX12B	421	O75342
KPLSHRFLRHVPVVY	DYNC1H1	2721	Q14204
HAIVRIFHPTYIKPV	CYP4F3	96	Q08477
QHPVHVSVVHLPIVY	SND1-IT1	86	Q9HBX3
LIPAHIFIPVFYRLH	SLC5A6	111	Q9Y289
IHRAVEFNPHVPKYL	ST7	406	Q9NRC1
PKQHFTYHIIVIILV	TACR3	241	P29371
ERGFIYVHKPPVHIR	SSRP1	356	Q08945
YVHKPPVHIRFDEIS	SSRP1	361	Q08945
IGFHLYHKLPTIVPE	SLC9A2	96	Q9UBY0
VLSHNRYHVPVVVVP	RPN2	261	P04844
VPTHTQVPVHRRYKH	SNX18	301	Q96RF0
VHKQYAIVFRTPPYH	NFKB2	281	Q00653