Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionandrosterone dehydrogenase (B-specific) activity

AKR1C1 AKR1C2 AKR1C3

1.05e-0641293GO:0047042
GeneOntologyMolecularFunctionketoreductase activity

AKR1C1 AKR1C2 AKR1C3

1.05e-0641293GO:0045703
GeneOntologyMolecularFunctionchlordecone reductase activity

AKR1C1 AKR1C2 AKR1C3

1.05e-0641293GO:0047743
GeneOntologyMolecularFunctiontrans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity

AKR1C1 AKR1C2 AKR1C3

2.61e-0651293GO:0047115
GeneOntologyMolecularFunction15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity

AKR1C1 AKR1C2 AKR1C3

2.61e-0651293GO:0047020
GeneOntologyMolecularFunction17-beta-ketosteroid reductase (NADPH) activity

AKR1C1 AKR1C2 AKR1C3

2.61e-0651293GO:0072555
GeneOntologyMolecularFunction17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity

AKR1C1 AKR1C2 AKR1C3

2.61e-0651293GO:0047006
GeneOntologyMolecularFunctionlithocholic acid binding

AKR1C1 AKR1C2 AKR1C3

2.61e-0651293GO:1902121
GeneOntologyMolecularFunctionketosteroid monooxygenase activity

AKR1C1 AKR1C2 AKR1C3

2.61e-0651293GO:0047086
GeneOntologyMolecularFunctionDelta4-3-oxosteroid 5beta-reductase activity

AKR1C1 AKR1C2 AKR1C3

2.61e-0651293GO:0047787
GeneOntologyMolecularFunctiongeranylgeranyl reductase activity

AKR1C1 AKR1C2 AKR1C3

5.19e-0661293GO:0045550
GeneOntologyMolecularFunction17-beta-hydroxysteroid dehydrogenase (NADP+) activity

AKR1C1 AKR1C2 AKR1C3

9.05e-0671293GO:0072582
GeneOntologyMolecularFunction5alpha-androstane-3beta,17beta-diol dehydrogenase activity

AKR1C1 AKR1C2 AKR1C3

1.44e-0581293GO:0047024
GeneOntologyMolecularFunctionandrosterone dehydrogenase activity

AKR1C1 AKR1C2 AKR1C3

1.44e-0581293GO:0047023
GeneOntologyMolecularFunctionenone reductase activity

AKR1C1 AKR1C2 AKR1C3

1.44e-0581293GO:0035671
GeneOntologyMolecularFunctionandrostan-3-alpha,17-beta-diol dehydrogenase activity

AKR1C1 AKR1C2 AKR1C3

2.15e-0591293GO:0047044
GeneOntologyMolecularFunctionNADP+ binding

AKR1C1 AKR1C2 AKR1C3

2.15e-0591293GO:0070401
GeneOntologyMolecularFunctiontestosterone 17-beta-dehydrogenase (NADP+) activity

AKR1C1 AKR1C2 AKR1C3

3.06e-05101293GO:0047045
GeneOntologyMolecularFunctionbile acid binding

AKR1C1 AKR1C2 AKR1C3

3.06e-05101293GO:0032052
GeneOntologyMolecularFunctionmonocarboxylic acid binding

AKR1C1 AKR1C2 IGF2R AKR1C3 ALB PC

6.86e-051071296GO:0033293
GeneOntologyMolecularFunctionaldose reductase (NADPH) activity

AKR1C1 AKR1C2 AKR1C3

9.10e-05141293GO:0004032
GeneOntologyMolecularFunctionretinal dehydrogenase activity

AKR1C1 AKR1C2 AKR1C3

9.10e-05141293GO:0001758
GeneOntologyMolecularFunctionindanol dehydrogenase activity

AKR1C1 AKR1C2

2.46e-0441292GO:0047718
GeneOntologyMolecularFunctionestradiol 17-beta-dehydrogenase [NAD(P)+] activity

AKR1C1 AKR1C2 AKR1C3

2.77e-04201293GO:0004303
GeneOntologyMolecularFunctionall-trans-retinol dehydrogenase (NAD+) activity

AKR1C1 AKR1C2 AKR1C3

4.83e-04241293GO:0004745
GeneOntologyMolecularFunctionalcohol dehydrogenase (NAD+) activity

AKR1C1 AKR1C2 AKR1C3

6.14e-04261293GO:0004022
GeneOntologyMolecularFunctionNADPH binding

AKR1C1 AKR1C2 AKR1C3

6.14e-04261293GO:0070402
GeneOntologyMolecularFunctionalcohol dehydrogenase (NADP+) activity

AKR1C1 AKR1C2 AKR1C3

6.88e-04271293GO:0008106
GeneOntologyMolecularFunctionalcohol dehydrogenase [NAD(P)+] activity

AKR1C1 AKR1C2 AKR1C3

9.41e-04301293GO:0018455
GeneOntologyMolecularFunctioncytoskeletal motor activity

KIF21B KIF27 KIF21A DNAH14 MYO3A

1.02e-031181295GO:0003774
GeneOntologyMolecularFunctionmicrotubule motor activity

KIF21B KIF27 KIF21A DNAH14

1.10e-03701294GO:0003777
GeneOntologyMolecularFunctionaldo-keto reductase (NADPH) activity

AKR1C1 AKR1C2 AKR1C3

1.14e-03321293GO:0004033
GeneOntologyMolecularFunctionsteroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

AKR1C1 AKR1C2 AKR1C3

1.25e-03331293GO:0033764
GeneOntologyMolecularFunctionoxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

AKR1C1 AKR1C2 AKR1C3

1.36e-03341293GO:0016628
GeneOntologyMolecularFunctionRNA endonuclease activity

NYNRIN ZC3H12D SLFN11 ELAC1

1.72e-03791294GO:0004521
GeneOntologyMolecularFunctionprotein kinase activity

PLK2 EPHA6 SCYL1 LMTK2 PASK MYO3A IGF2R DCLK3 PRKCE PLK1 MAP2K7

1.79e-0360012911GO:0004672
GeneOntologyMolecularFunctionsteroid dehydrogenase activity

AKR1C1 AKR1C2 AKR1C3

2.03e-03391293GO:0016229
GeneOntologyMolecularFunctionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

AKR1C1 AKR1C2 AKR1C3

2.19e-03401293GO:0016709
GeneOntologyMolecularFunctionphosphatidylinositol-3,5-bisphosphate 3-phosphatase activity

MTMR7 MTMR2

2.19e-03111292GO:0052629
GeneOntologyMolecularFunctiontestosterone dehydrogenase [NAD(P)+] activity

AKR1C1 AKR1C3

2.19e-03111292GO:0030283
GeneOntologyMolecularFunctionprotein serine kinase activity

PLK2 LMTK2 PASK MYO3A DCLK3 PRKCE PLK1 MAP2K7

2.50e-033631298GO:0106310
GeneOntologyMolecularFunctionphosphatidylinositol-3-phosphate phosphatase activity

MTMR7 MTMR2

3.58e-03141292GO:0004438
GeneOntologyMolecularFunctionoxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

AKR1C1 AKR1C2 AKR1C3

3.69e-03481293GO:0016620
GeneOntologyMolecularFunctionphosphatidylinositol monophosphate phosphatase activity

MTMR7 MTMR2

4.12e-03151292GO:0052744
GeneOntologyMolecularFunctioncarboxylic acid binding

AKR1C1 AKR1C2 IGF2R AKR1C3 ALB PC

4.63e-032391296GO:0031406
GeneOntologyMolecularFunctionphosphatidylinositol-3,5-bisphosphate phosphatase activity

MTMR7 MTMR2

4.68e-03161292GO:0106018
GeneOntologyMolecularFunctionneurexin family protein binding

NLGN3 NLGN2

4.68e-03161292GO:0042043
GeneOntologyBiologicalProcessresponse to jasmonic acid

AKR1C1 AKR1C2 AKR1C3

9.30e-0741283GO:0009753
GeneOntologyBiologicalProcessprogesterone catabolic process

AKR1C1 AKR1C2 AKR1C3

9.30e-0741283GO:0006709
GeneOntologyBiologicalProcesscellular response to jasmonic acid stimulus

AKR1C1 AKR1C2 AKR1C3

9.30e-0741283GO:0071395
GeneOntologyBiologicalProcessC21-steroid hormone catabolic process

AKR1C1 AKR1C2 AKR1C3

9.30e-0741283GO:0008208
GeneOntologyBiologicalProcessnegative regulation of excitatory postsynaptic potential

PLK2 SYNE1 NLGN3 MTMR2

1.83e-06151284GO:0090394
GeneOntologyBiologicalProcessfarnesol metabolic process

AKR1C1 AKR1C2 AKR1C3

2.31e-0651283GO:0016487
GeneOntologyBiologicalProcessfarnesol catabolic process

AKR1C1 AKR1C2 AKR1C3

2.31e-0651283GO:0016488
GeneOntologyBiologicalProcessnegative regulation of isoprenoid metabolic process

AKR1C1 AKR1C2 AKR1C3

2.31e-0651283GO:0045827
GeneOntologyBiologicalProcesssesquiterpenoid catabolic process

AKR1C1 AKR1C2 AKR1C3

2.31e-0651283GO:0016107
GeneOntologyBiologicalProcessolefinic compound catabolic process

AKR1C1 AKR1C2 AKR1C3

2.31e-0651283GO:0120256
GeneOntologyBiologicalProcessnegative regulation of retinoic acid biosynthetic process

AKR1C1 AKR1C2 AKR1C3

2.31e-0651283GO:1900053
GeneOntologyBiologicalProcesssesquiterpenoid metabolic process

AKR1C1 AKR1C2 AKR1C3

4.61e-0661283GO:0006714
GeneOntologyBiologicalProcesspolyprenol catabolic process

AKR1C1 AKR1C2 AKR1C3

4.61e-0661283GO:0016095
GeneOntologyBiologicalProcessresponse to prostaglandin D

AKR1C1 AKR1C2 AKR1C3

8.02e-0671283GO:0071798
GeneOntologyBiologicalProcesscellular response to prostaglandin D stimulus

AKR1C1 AKR1C2 AKR1C3

8.02e-0671283GO:0071799
GeneOntologyBiologicalProcessregulation of retinoic acid biosynthetic process

AKR1C1 AKR1C2 AKR1C3

8.02e-0671283GO:1900052
GeneOntologyBiologicalProcesscellular response to prostaglandin stimulus

AKR1C1 AKR1C2 AKR1C3 PRKCE

1.14e-05231284GO:0071379
GeneOntologyBiologicalProcessdaunorubicin metabolic process

AKR1C1 AKR1C2 AKR1C3

1.91e-0591283GO:0044597
GeneOntologyBiologicalProcessdoxorubicin metabolic process

AKR1C1 AKR1C2 AKR1C3

2.71e-05101283GO:0044598
GeneOntologyBiologicalProcessregulation of isoprenoid metabolic process

AKR1C1 AKR1C2 AKR1C3

2.71e-05101283GO:0019747
GeneOntologyBiologicalProcessnegative regulation of vitamin metabolic process

AKR1C1 AKR1C2 AKR1C3

2.71e-05101283GO:0046137
GeneOntologyBiologicalProcesspolyketide metabolic process

AKR1C1 AKR1C2 AKR1C3

2.71e-05101283GO:0030638
GeneOntologyBiologicalProcessaminoglycoside antibiotic metabolic process

AKR1C1 AKR1C2 AKR1C3

2.71e-05101283GO:0030647
GeneOntologyBiologicalProcessregulation of testosterone biosynthetic process

AKR1C1 AKR1C2 AKR1C3

3.71e-05111283GO:2000224
GeneOntologyBiologicalProcessterpenoid catabolic process

AKR1C1 AKR1C2 AKR1C3

3.71e-05111283GO:0016115
GeneOntologyBiologicalProcessmodulation of excitatory postsynaptic potential

PLK2 SYNE1 NLGN3 MTMR2 NLGN2

5.22e-05651285GO:0098815
GeneOntologyBiologicalProcessresponse to prostaglandin

AKR1C1 AKR1C2 AKR1C3 PRKCE

7.15e-05361284GO:0034694
GeneOntologyBiologicalProcessretinoic acid biosynthetic process

AKR1C1 AKR1C2 AKR1C3

8.08e-05141283GO:0002138
GeneOntologyBiologicalProcessisoprenoid catabolic process

AKR1C1 AKR1C2 AKR1C3

8.08e-05141283GO:0008300
GeneOntologyBiologicalProcessditerpenoid biosynthetic process

AKR1C1 AKR1C2 AKR1C3

1.01e-04151283GO:0016102
GeneOntologyBiologicalProcesstestosterone biosynthetic process

AKR1C1 AKR1C2 AKR1C3

1.23e-04161283GO:0061370
GeneOntologyBiologicalProcessnegative regulation of hormone metabolic process

AKR1C1 AKR1C2 AKR1C3

1.23e-04161283GO:0032351
GeneOntologyBiologicalProcessregulation of vitamin metabolic process

AKR1C1 AKR1C2 AKR1C3

1.78e-04181283GO:0030656
GeneOntologyBiologicalProcesshormone catabolic process

AKR1C1 AKR1C2 AKR1C3

2.86e-04211283GO:0042447
GeneOntologyBiologicalProcessterpenoid biosynthetic process

AKR1C1 AKR1C2 AKR1C3

2.86e-04211283GO:0016114
GeneOntologyBiologicalProcessregulation of retinoic acid receptor signaling pathway

AKR1C1 AKR1C2 AKR1C3

2.86e-04211283GO:0048385
GeneOntologyBiologicalProcessretinal metabolic process

AKR1C1 AKR1C2 AKR1C3

2.86e-04211283GO:0042574
GeneOntologyBiologicalProcessketone catabolic process

AKR1C1 AKR1C2 AKR1C3

2.86e-04211283GO:0042182
GeneOntologyBiologicalProcessendocytic recycling

VPS39 LMTK2 EHD4 EHD3 EHD1

3.15e-04951285GO:0032456
GeneOntologyBiologicalProcessaldehyde metabolic process

IDH2 AKR1C1 AKR1C2 AKR1C3 PC

3.15e-04951285GO:0006081
GeneOntologyBiologicalProcessparturition

AKR1C1 AKR1C2 AKR1C3

3.30e-04221283GO:0007567
GeneOntologyBiologicalProcessglycoside metabolic process

AKR1C1 AKR1C2 AKR1C3

3.30e-04221283GO:0016137
GeneOntologyBiologicalProcessprogesterone metabolic process

AKR1C1 AKR1C2 AKR1C3

3.30e-04221283GO:0042448
GeneOntologyBiologicalProcesstertiary alcohol metabolic process

AKR1C1 AKR1C2 AKR1C3

3.30e-04221283GO:1902644
GeneOntologyBiologicalProcessprimary alcohol catabolic process

AKR1C1 AKR1C2 AKR1C3

3.78e-04231283GO:0034310
GeneOntologyBiologicalProcessregulation of cytokinesis

DCDC1 AHCTF1 BIRC6 PRKCE PLK1

3.82e-04991285GO:0032465
GeneOntologyBiologicalProcessprostaglandin metabolic process

DAGLB AKR1C1 AKR1C2 AKR1C3

4.05e-04561284GO:0006693
GeneOntologyBiologicalProcessprostanoid metabolic process

DAGLB AKR1C1 AKR1C2 AKR1C3

4.33e-04571284GO:0006692
GeneOntologyBiologicalProcessregulation of ketone biosynthetic process

AKR1C1 AKR1C2 AKR1C3

5.47e-04261283GO:0010566
GeneOntologyBiologicalProcessregulation of respiratory gaseous exchange

PASK NLGN3 NLGN2

6.12e-04271283GO:0043576
GeneOntologyBiologicalProcessnegative regulation of mRNA splicing, via spliceosome

AKR1C1 AKR1C2 AKR1C3

6.83e-04281283GO:0048025
GeneOntologyBiologicalProcesspolyprenol metabolic process

AKR1C1 AKR1C2 AKR1C3

7.58e-04291283GO:0016093
GeneOntologyBiologicalProcessnegative regulation of mRNA processing

AKR1C1 AKR1C2 AKR1C3

7.58e-04291283GO:0050686
GeneOntologyBiologicalProcesssecondary metabolic process

DCT AKR1C1 AKR1C2 AKR1C3

8.02e-04671284GO:0019748
GeneOntologyBiologicalProcessresponse to fatty acid

PCSK1 AKR1C1 AKR1C2 AKR1C3

8.96e-04691284GO:0070542
GeneOntologyBiologicalProcesspositive regulation of endothelial cell apoptotic process

AKR1C1 AKR1C2 AKR1C3

1.02e-03321283GO:2000353
GeneOntologyBiologicalProcesspositive regulation of protein localization to synapse

NLGN3 NLGN2

1.04e-0381282GO:1902474
GeneOntologyBiologicalProcesspositive regulation of antimicrobial humoral response

ACOD1 KLK5

1.04e-0381282GO:0002760
GeneOntologyBiologicalProcesspositive regulation of synaptic vesicle clustering

NLGN3 NLGN2

1.04e-0381282GO:2000809
GeneOntologyBiologicalProcessnegative regulation of RNA splicing

AKR1C1 AKR1C2 AKR1C3

1.11e-03331283GO:0033119
GeneOntologyBiologicalProcessregulation of endothelial cell apoptotic process

NDNF AKR1C1 AKR1C2 AKR1C3

1.16e-03741284GO:2000351
GeneOntologyBiologicalProcesssteroid catabolic process

AKR1C1 AKR1C2 AKR1C3

1.21e-03341283GO:0006706
GeneOntologyBiologicalProcesscellular response to ketone

AKR1C1 AKR1C2 ACOD1 AKR1C3 PRKCE

1.31e-031301285GO:1901655
GeneOntologyBiologicalProcessexcitatory postsynaptic potential

PLK2 SYNE1 NLGN3 MTMR2 NLGN2

1.31e-031301285GO:0060079
GeneOntologyBiologicalProcessolefinic compound biosynthetic process

AKR1C1 AKR1C2 AKR1C3

1.32e-03351283GO:0120255
GeneOntologyBiologicalProcessterminal button organization

NLGN3 NLGN2

1.34e-0391282GO:0072553
GeneOntologyCellularComponentciliary pocket membrane

EHD3 EHD1

1.09e-0431272GO:0020018
GeneOntologyCellularComponentciliary pocket

EHD3 EHD1

1.09e-0431272GO:0020016
GeneOntologyCellularComponentsymmetric, GABA-ergic, inhibitory synapse

NLGN3 NLGN2

2.18e-0441272GO:0098983
MousePhenolong stride length

AKR1C1 AKR1C2 MTMR2 AKR1C3

4.15e-06151074MP:0010540
MousePhenoparturition failure

AKR1C1 AKR1C2 AKR1C3

5.03e-05101073MP:0012010
MousePhenohypermyelination

AKR1C1 AKR1C2 AKR1C3

6.88e-05111073MP:0010050
MousePhenoincreased oligodendrocyte number

AKR1C1 AKR1C2 AKR1C3

1.18e-04131073MP:0010160
MousePhenoabnormal aortic valve commissure morphology

ADAMTS19 PLCE1

1.73e-0431072MP:0031166
MousePhenoincreased circulating progesterone level

AKR1C1 AKR1C2 AKR1C3

1.86e-04151073MP:0005186
MousePhenolong gestation period

AKR1C1 AKR1C2 AKR1C3

1.86e-04151073MP:0002293
MousePhenoenhanced coordination

AKR1C1 AKR1C2 NLGN3 AKR1C3

1.96e-04381074MP:0003858
DomainEHD_N

EHD4 EHD3 EHD1 SRL

1.11e-0851304IPR031692
DomainEHD_N

EHD4 EHD3 EHD1 SRL

1.11e-0851304PF16880
DomainG_DYNAMIN_dom

EHD4 EHD3 EHD1 SRL

2.13e-06141304IPR030381
DomainG_DYNAMIN_2

EHD4 EHD3 EHD1 SRL

2.13e-06141304PS51718
DomainDynamin_GTPase

EHD4 EHD3 EHD1 SRL

2.88e-06151304IPR001401
DomainDynamin_SF

EHD4 EHD3 EHD1 SRL

2.88e-06151304IPR022812
DomainDynamin_N

EHD4 EHD3 EHD1 SRL

2.88e-06151304PF00350
DomainALDOKETO_REDUCTASE_1

AKR1C1 AKR1C2 AKR1C3

3.82e-05101303PS00798
DomainALDOKETO_REDUCTASE_2

AKR1C1 AKR1C2 AKR1C3

3.82e-05101303PS00062
DomainALDOKETO_REDUCTASE_3

AKR1C1 AKR1C2 AKR1C3

3.82e-05101303PS00063
DomainAldo/ket_reductase_CS

AKR1C1 AKR1C2 AKR1C3

3.82e-05101303IPR018170
DomainAldo/keto_reductase

AKR1C1 AKR1C2 AKR1C3

3.82e-05101303IPR020471
DomainEF-hand_4

EHD4 EHD3 EHD1

3.82e-05101303PF12763
DomainEHD1/EHD3

EHD3 EHD1

4.81e-0521302IPR029951
DomainEH

EHD4 EHD3 EHD1

5.22e-05111303PS50031
DomainEH

EHD4 EHD3 EHD1

5.22e-05111303SM00027
DomainEH_dom

EHD4 EHD3 EHD1

5.22e-05111303IPR000261
DomainPOLO_box_2

PLK2 PLK1

1.44e-0431302IPR033695
DomainSPAR_C

SIPA1L1 SIPA1L2

1.44e-0431302PF11881
DomainSIPA1L_C

SIPA1L1 SIPA1L2

1.44e-0431302IPR021818
Domain-

AKR1C1 AKR1C2 AKR1C3

1.73e-041613033.20.20.100
DomainNADP_OxRdtase_dom

AKR1C1 AKR1C2 AKR1C3

2.09e-04171303IPR023210
DomainAldo_ket_red

AKR1C1 AKR1C2 AKR1C3

2.09e-04171303PF00248
DomainAldo/ket_red/Kv-b

AKR1C1 AKR1C2 AKR1C3

2.09e-04171303IPR001395
Domain-

PLK2 PLK1

2.86e-04413023.30.1120.30
DomainPOLO_box

PLK2 PLK1

2.86e-0441302PF00659
DomainPOLO_box_1

PLK2 PLK1

2.86e-0441302IPR033701
DomainPOLO_BOX

PLK2 PLK1

2.86e-0441302PS50078
DomainTMEM132D_N

TMEM132C TMEM132D

4.74e-0451302PF15705
DomainTMEM132D_C

TMEM132C TMEM132D

4.74e-0451302PF15706
DomainTMEM132_M

TMEM132C TMEM132D

4.74e-0451302IPR031437
DomainTMEM132_C

TMEM132C TMEM132D

4.74e-0451302IPR031436
DomainPOLO_box_dom

PLK2 PLK1

4.74e-0451302IPR000959
DomainTMEM132_N

TMEM132C TMEM132D

4.74e-0451302IPR031435
DomainTMEM132

TMEM132C TMEM132D

4.74e-0451302IPR026307
DomainNlgn

NLGN3 NLGN2

4.74e-0451302IPR000460
DomainTMEM132

TMEM132C TMEM132D

4.74e-0451302PF16070
DomainPeptidase_M12B_ADAM-TS

ADAMTS19 ADAMTSL1 ADAMTS5

5.99e-04241303IPR013273
DomainTSP_1

ADAMTS19 ADAMTSL1 ADAMTS5 C8B

9.72e-04631304PF00090
DomainRNase_Zc3h12a

NYNRIN ZC3H12D

9.87e-0471302PF11977
DomainRNase_Zc3h12_NYN

NYNRIN ZC3H12D

9.87e-0471302IPR021869
DomainTSP1

ADAMTS19 ADAMTSL1 ADAMTS5 C8B

1.09e-03651304SM00209
DomainTSP1_rpt

ADAMTS19 ADAMTSL1 ADAMTS5 C8B

1.09e-03651304IPR000884
DomainTSP1

ADAMTS19 ADAMTSL1 ADAMTS5 C8B

1.09e-03651304PS50092
DomainRap_GAP

SIPA1L1 SIPA1L2

2.09e-03101302PF02145
DomainProt_kinase_dom

PLK2 EPHA6 SCYL1 LMTK2 PASK MYO3A DCLK3 PRKCE PLK1 MAP2K7

2.24e-0348913010IPR000719
DomainPROTEIN_KINASE_DOM

PLK2 EPHA6 SCYL1 LMTK2 PASK MYO3A DCLK3 PRKCE PLK1 MAP2K7

2.37e-0349313010PS50011
DomainRap_GAP_dom

SIPA1L1 SIPA1L2

2.54e-03111302IPR000331
DomainRAPGAP

SIPA1L1 SIPA1L2

2.54e-03111302PS50085
DomainKinesin_motor_CS

KIF21B KIF27 KIF21A

2.90e-03411303IPR019821
DomainKinesin-like_fam

KIF21B KIF27 KIF21A

3.32e-03431303IPR027640
Domain-

KIF21B KIF27 KIF21A

3.54e-034413033.40.850.10
DomainKinesin

KIF21B KIF27 KIF21A

3.54e-03441303PF00225
DomainKISc

KIF21B KIF27 KIF21A

3.54e-03441303SM00129
DomainKINESIN_MOTOR_1

KIF21B KIF27 KIF21A

3.54e-03441303PS00411
DomainKinesin_motor_dom

KIF21B KIF27 KIF21A

3.54e-03441303IPR001752
DomainKINESIN_MOTOR_2

KIF21B KIF27 KIF21A

3.54e-03441303PS50067
DomainCarboxylesterase_B_CS

NLGN3 NLGN2

3.57e-03131302IPR019819
DomainMyotubularin-like_Pase_dom

MTMR7 MTMR2

4.14e-03141302IPR010569
DomainCARBOXYLESTERASE_B_2

NLGN3 NLGN2

4.14e-03141302PS00941
DomainCOesterase

NLGN3 NLGN2

4.14e-03141302PF00135
DomainPLAC

ADAMTS19 ADAMTSL1

4.14e-03141302PF08686
DomainPPASE_MYOTUBULARIN

MTMR7 MTMR2

4.14e-03141302PS51339
DomainMyotubularin_fam

MTMR7 MTMR2

4.14e-03141302IPR030564
DomainMyotub-related

MTMR7 MTMR2

4.14e-03141302PF06602
DomainCarbesteraseB

NLGN3 NLGN2

4.14e-03141302IPR002018
DomainKinase-like_dom

PLK2 EPHA6 SCYL1 LMTK2 PASK MYO3A DCLK3 PRKCE PLK1 MAP2K7

4.64e-0354213010IPR011009
DomainPROTEIN_KINASE_ATP

PLK2 EPHA6 LMTK2 PASK MYO3A DCLK3 PRKCE PLK1 MAP2K7

4.85e-034591309PS00107
DomainProtein_kinase_ATP_BS

PLK2 EPHA6 LMTK2 PASK MYO3A DCLK3 PRKCE PLK1

5.07e-033791308IPR017441
DomainPkinase

PLK2 SCYL1 PASK MYO3A DCLK3 PRKCE PLK1 MAP2K7

5.23e-033811308PF00069
PathwayREACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_24_HYDROXYCHOLESTEROL

CYP8B1 AKR1C1 AKR1C2 AKR1C3

1.02e-0613894M17842
PathwayREACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_24_HYDROXYCHOLESTEROL

CYP8B1 AKR1C1 AKR1C2 AKR1C3

1.02e-0613894MM14747
PathwayREACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_27_HYDROXYCHOLESTEROL

CYP8B1 AKR1C1 AKR1C2 AKR1C3

1.42e-0614894M27074
PathwayREACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_27_HYDROXYCHOLESTEROL

CYP8B1 AKR1C1 AKR1C2 AKR1C3

1.42e-0614894MM14748
PathwayREACTOME_SYNTHESIS_OF_PROSTAGLANDINS_PG_AND_THROMBOXANES_TX

CYP8B1 AKR1C1 AKR1C2 AKR1C3

1.92e-0615894MM14870
PathwayREACTOME_BILE_ACID_AND_BILE_SALT_METABOLISM

CYP8B1 AKR1C1 AKR1C2 AKR1C3 ALB

8.01e-0644895M499
PathwayREACTOME_BILE_ACID_AND_BILE_SALT_METABOLISM

CYP8B1 AKR1C1 AKR1C2 AKR1C3 ALB

8.97e-0645895MM14751
PathwayREACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_7ALPHA_HYDROXYCHOLESTEROL

CYP8B1 AKR1C1 AKR1C2 AKR1C3

1.20e-0523894M1926
PathwayREACTOME_PREDNISONE_ADME

AKR1C1 AKR1C2 AKR1C3 ALB

1.20e-0523894MM16639
PathwayREACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_7ALPHA_HYDROXYCHOLESTEROL

CYP8B1 AKR1C1 AKR1C2 AKR1C3

1.20e-0523894MM14741
PathwayWP_BENZOAPYRENE_METABOLISM

AKR1C1 AKR1C2 AKR1C3

1.99e-059893M39344
PathwayKEGG_MEDICUS_ENV_FACTOR_METALS_TO_KEAP1_NRF2_SIGNALIG_PATHWAY

AKR1C1 AKR1C2 AKR1C3

1.99e-059893M47817
PathwayKEGG_MEDICUS_ENV_FACTOR_BENZO_A_PYRENRE_TO_CYP_MEDIATED_METABOLISM

AKR1C1 AKR1C2 AKR1C3

3.87e-0511893M47812
PathwayREACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS

CYP8B1 AKR1C1 AKR1C2 AKR1C3

5.28e-0533894M5967
PathwayREACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS

CYP8B1 AKR1C1 AKR1C2 AKR1C3

5.28e-0533894MM14737
PathwayWP_GLUCOCORTICOID_BIOSYNTHESIS

AKR1C1 AKR1C2 AKR1C3

8.42e-0514893M46449
PathwayWP_MINERALOCORTICOID_BIOSYNTHESIS

AKR1C1 AKR1C2 AKR1C3

8.42e-0514893M46453
PathwayREACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS

CYP8B1 AKR1C1 AKR1C2 MTHFD1 BTD AKR1C3 PC

1.90e-04189897MM14772
PathwayREACTOME_ARACHIDONIC_ACID_METABOLISM

CYP8B1 AKR1C1 AKR1C2 AKR1C3

5.89e-0461894MM14861
PathwayREACTOME_O_LINKED_GLYCOSYLATION

ADAMTS19 ADAMTSL1 ADAMTS5 GALNT7 GALNT8

6.79e-04111895M27416
PathwayREACTOME_RA_BIOSYNTHESIS_PATHWAY

AKR1C1 AKR1C2 AKR1C3

7.11e-0428893MM15188
PathwayREACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION

KIF21B KIF27 KIF21A EHD3 EHD1

8.28e-04116895MM15715
PathwayREACTOME_DEFECTS_IN_BIOTIN_BTN_METABOLISM

BTD PC

1.08e-038892M27248
PathwayREACTOME_METABOLISM_OF_STEROIDS

CYP8B1 AKR1C1 AKR1C2 AKR1C3 ALB

1.20e-03126895MM15553
Pubmed

Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.

VPS39 AHCTF1 LMTK2 GPR183 SRCAP GALNT7 AKR1C1 AKR1C2 DNTTIP2 EHD3 NLGN3 IGF2R RESF1 TEX264 PTPRR MTHFD1 SIPA1L1 AKR1C3 BICC1

2.36e-0810841301911544199
Pubmed

Aldo-keto reductase 1C subfamily genes in skin are UV-inducible: possible role in keratinocytes survival.

AKR1C1 AKR1C2 AKR1C3

5.10e-083130319320734
Pubmed

Aldo-keto reductases protect metastatic melanoma from ER stress-independent ferroptosis.

AKR1C1 AKR1C2 AKR1C3

5.10e-083130331780644
Pubmed

Aldo-keto reductases AKR1C1, AKR1C2 and AKR1C3 may enhance progesterone metabolism in ovarian endometriosis.

AKR1C1 AKR1C2 AKR1C3

5.10e-083130321232532
Pubmed

Altered expression of 3 alpha-hydroxysteroid dehydrogenases in human glaucomatous optic nerve head astrocytes.

AKR1C1 AKR1C2 AKR1C3

5.10e-083130313678667
Pubmed

Differential roles of C-terminal Eps15 homology domain proteins as vesiculators and tubulators of recycling endosomes.

EHD4 EHD3 EHD1

5.10e-083130324019528
Pubmed

The Diet1 locus confers protection against hypercholesterolemia through enhanced bile acid metabolism.

CYP8B1 AKR1C1 AKR1C2 AKR1C3

1.30e-0713130411682476
Pubmed

Studies on a Tyr residue critical for the binding of coenzyme and substrate in mouse 3(17)alpha-hydroxysteroid dehydrogenase (AKR1C21): structure of the Y224D mutant enzyme.

AKR1C1 AKR1C2 AKR1C3

2.04e-074130320124700
Pubmed

Structure and activity of the murine type 5 17beta-hydroxysteroid dehydrogenase gene(1).

AKR1C1 AKR1C2 AKR1C3

2.04e-074130310500239
Pubmed

Enzymatic properties of a member (AKR1C20) of the aldo-keto reductase family.

AKR1C1 AKR1C2 AKR1C3

2.04e-074130316508162
Pubmed

AKR1C isoforms represent a novel cellular target for jasmonates alongside their mitochondrial-mediated effects.

AKR1C1 AKR1C2 AKR1C3

2.04e-074130319487289
Pubmed

Cloning and chromosomal localization of mouse 20alpha-hydroxysteroid dehydrogenase gene.

AKR1C1 AKR1C2 AKR1C3

2.04e-074130314967952
Pubmed

Assignment of HSD17B5 encoding type 5 17 beta-hydroxysteroid dehydrogenase to human chromosome bands 10p15-->p14 and mouse chromosome 13 region A2 by in situ hybridization: identification of a new syntenic relationship.

AKR1C1 AKR1C2 AKR1C3

2.04e-074130310393440
Pubmed

Localization of 20alpha-hydroxysteroid dehydrogenase mRNA in mouse brain by in situ hybridization.

AKR1C1 AKR1C2 AKR1C3

2.04e-074130315193432
Pubmed

C-terminal EH-domain-containing proteins: consensus for a role in endocytic trafficking, EH?

EHD4 EHD3 EHD1

2.04e-074130316155252
Pubmed

Mouse Akr1cl gene product is a prostaglandin D2 11-ketoreductase with strict substrate specificity.

AKR1C1 AKR1C2 AKR1C3

2.04e-074130331479646
Pubmed

Characterization and functional analysis of the 5'-flanking region of the mouse 20alpha-hydroxysteroid dehydrogenase gene.

AKR1C1 AKR1C2 AKR1C3

2.04e-074130315222881
Pubmed

Isolation and characterization of a cDNA encoding mouse 3alpha-hydroxysteroid dehydrogenase: an androgen-inactivating enzyme selectively expressed in female tissues.

AKR1C1 AKR1C2 AKR1C3

2.04e-074130316191478
Pubmed

Role of the EHD Family of Endocytic Recycling Regulators for TCR Recycling and T Cell Function.

EHD4 EHD3 EHD1

2.04e-074130329212907
Pubmed

Characterization of two isoforms of mouse 3(17)alpha-hydroxysteroid dehydrogenases of the aldo-keto reductase family.

AKR1C1 AKR1C2 AKR1C3

2.04e-074130315577209
Pubmed

Identification of an interleukin-3-regulated aldoketo reductase gene in myeloid cells which may function in autocrine regulation of myelopoiesis.

AKR1C1 AKR1C2 AKR1C3

2.04e-074130310702227
Pubmed

Shared as well as distinct roles of EHD proteins revealed by biochemical and functional comparisons in mammalian cells and C. elegans.

EHD4 EHD3 EHD1

2.04e-074130317233914
Pubmed

Crystal structures of mouse 17alpha-hydroxysteroid dehydrogenase (apoenzyme and enzyme-NADP(H) binary complex): identification of molecular determinants responsible for the unique 17alpha-reductive activity of this enzyme.

AKR1C1 AKR1C2 AKR1C3

2.04e-074130317034817
Pubmed

Several distinct enzymes catalyze 20alpha-hydroxysteroid dehydrogenase activity in mouse liver and kidney.

AKR1C1 AKR1C2 AKR1C3

2.04e-074130317629694
Pubmed

EHD2, EHD3, and EHD4 encode novel members of a highly conserved family of EH domain-containing proteins.

EHD4 EHD3 EHD1

2.04e-074130310673336
Pubmed

RECON-Dependent Inflammation in Hepatocytes Enhances Listeria monocytogenes Cell-to-Cell Spread.

AKR1C1 AKR1C2 AKR1C3

2.04e-074130329764944
Pubmed

Cloning and characterization of two novel aldo-keto reductases (AKR1C12 and AKR1C13) from mouse stomach.

AKR1C1 AKR1C2 AKR1C3

2.04e-074130310526179
Pubmed

Characterization of rat and mouse NAD+-dependent 3alpha/17beta/20alpha-hydroxysteroid dehydrogenases and identification of substrate specificity determinants by site-directed mutagenesis.

AKR1C1 AKR1C2 AKR1C3

2.04e-074130317888864
Pubmed

Mouse 17alpha-hydroxysteroid dehydrogenase (AKR1C21) binds steroids differently from other aldo-keto reductases: identification and characterization of amino acid residues critical for substrate binding.

AKR1C1 AKR1C2 AKR1C3

2.04e-074130317442338
Pubmed

Sensing of Bacterial Cyclic Dinucleotides by the Oxidoreductase RECON Promotes NF-κB Activation and Shapes a Proinflammatory Antibacterial State.

AKR1C1 AKR1C2 AKR1C3

2.04e-074130328329705
Pubmed

Characterization of 17alpha-hydroxysteroid dehydrogenase activity (17alpha-HSD) and its involvement in the biosynthesis of epitestosterone.

AKR1C1 AKR1C2 AKR1C3

2.04e-074130316018803
Pubmed

Reproductive phenotypes in mice with targeted disruption of the 20alpha-hydroxysteroid dehydrogenase gene.

AKR1C1 AKR1C2 AKR1C3

2.04e-074130317272929
Pubmed

Structure of the G225P/G226P mutant of mouse 3(17)alpha-hydroxysteroid dehydrogenase (AKR1C21) ternary complex: implications for the binding of inhibitor and substrate.

AKR1C1 AKR1C2 AKR1C3

2.04e-074130319237748
Pubmed

Involvement of 20alpha-hydroxysteroid dehydrogenase in the maintenance of pregnancy in mice.

AKR1C1 AKR1C2 AKR1C3

2.04e-074130318667791
Pubmed

Mefenamic acid enhances anticancer drug sensitivity via inhibition of aldo-keto reductase 1C enzyme activity.

AKR1C1 AKR1C2 AKR1C3

2.04e-074130328259989
Pubmed

Stereospecific reduction of 5β-reduced steroids by human ketosteroid reductases of the AKR (aldo-keto reductase) superfamily: role of AKR1C1-AKR1C4 in the metabolism of testosterone and progesterone via the 5β-reductase pathway.

AKR1C1 AKR1C2 AKR1C3

2.04e-074130321521174
Pubmed

Molecular cloning of multiple cDNAs encoding human enzymes structurally related to 3 alpha-hydroxysteroid dehydrogenase.

AKR1C1 AKR1C2 AKR1C3

2.04e-07413038274401
Pubmed

Crystallization and preliminary X-ray diffraction analysis of mouse 3(17)alpha-hydroxysteroid dehydrogenase.

AKR1C1 AKR1C2 AKR1C3

2.04e-074130316511129
Pubmed

Identification of the oxidative 3alpha-hydroxysteroid dehydrogenase activity of rat Leydig cells as type II retinol dehydrogenase.

AKR1C1 AKR1C2 AKR1C3

2.04e-074130310803568
Pubmed

AKR1C1 alleviates LPS‑induced ALI in mice by activating the JAK2/STAT3 signaling pathway.

AKR1C1 AKR1C2 AKR1C3

2.04e-074130334590152
Pubmed

Localization of multiple human dihydrodiol dehydrogenase (DDH1 and DDH2) and chlordecone reductase (CHDR) genes in chromosome 10 by the polymerase chain reaction and fluorescence in situ hybridization.

AKR1C1 AKR1C2 AKR1C3

2.04e-07413037789999
Pubmed

Molecular cloning and characterization of mouse estradiol 17 beta-dehydrogenase (A-specific), a member of the aldoketoreductase family.

AKR1C1 AKR1C2 AKR1C3

5.08e-07513037737980
Pubmed

Retinaldehyde is a substrate for human aldo-keto reductases of the 1C subfamily.

AKR1C1 AKR1C2 AKR1C3

5.08e-075130321851338
Pubmed

Preterm birth without progesterone withdrawal in 15-hydroxyprostaglandin dehydrogenase hypomorphic mice.

AKR1C1 AKR1C2 AKR1C3

5.08e-075130317872381
Pubmed

EH domain proteins regulate cardiac membrane protein targeting.

EHD4 EHD3 EHD1

5.08e-075130320489164
Pubmed

Mouse 3alpha-hydroxysteroid dehydrogenase mRNA: a marker of lung maturity.

AKR1C1 AKR1C2 AKR1C3

5.08e-075130317064890
Pubmed

Close kinship of human 20alpha-hydroxysteroid dehydrogenase gene with three aldo-keto reductase genes.

AKR1C1 AKR1C2 AKR1C3

5.08e-075130310672042
Pubmed

Pregnane X receptor (PXR) deficiency promotes hepatocarcinogenesis via induction of Akr1c18 expression and prostaglandin F2α (PGF2α) levels.

AKR1C1 AKR1C2 AKR1C3

5.08e-075130338788959
Pubmed

Expression of progesterone metabolizing enzyme genes (AKR1C1, AKR1C2, AKR1C3, SRD5A1, SRD5A2) is altered in human breast carcinoma.

AKR1C1 AKR1C2 AKR1C3

5.08e-075130315212687
Pubmed

Characterization of brain neurons that express enzymes mediating neurosteroid biosynthesis.

AKR1C1 AKR1C2 AKR1C3

5.08e-075130316984997
Pubmed

Down-regulation of neurosteroid biosynthesis in corticolimbic circuits mediates social isolation-induced behavior in mice.

AKR1C1 AKR1C2 AKR1C3

5.08e-075130318003893
Pubmed

The Gαq/11-provoked induction of Akr1c18 in murine luteal cells is mediated by phospholipase C.

AKR1C1 AKR1C2 AKR1C3

1.01e-066130329107092
Pubmed

Expression analysis of the aldo-keto reductases involved in the novel biosynthetic pathway of tetrahydrobiopterin in human and mouse tissues.

AKR1C1 AKR1C2 AKR1C3

1.01e-066130319273550
Pubmed

Quantitative appreciation of steroidogenic gene expression in mouse tissues: new roles for type 2 5alpha-reductase, 20alpha-hydroxysteroid dehydrogenase and estrogen sulfotransferase.

AKR1C1 AKR1C2 AKR1C3

1.01e-066130315860270
Pubmed

Regulation of progesterone levels during pregnancy and parturition by signal transducer and activator of transcription 5 and 20alpha-hydroxysteroid dehydrogenase.

AKR1C1 AKR1C2 AKR1C3

1.01e-066130315471942
Pubmed

MICAL-L1 links EHD1 to tubular recycling endosomes and regulates receptor recycling.

EHD4 EHD3 EHD1

1.01e-066130319864458
Pubmed

MEF2 and NR2F2 cooperate to regulate Akr1c14 gene expression in mouse MA-10 Leydig cells.

AKR1C1 AKR1C2 AKR1C3

1.01e-066130326748576
Pubmed

Adrenal 20alpha-hydroxysteroid dehydrogenase in the mouse catabolizes progesterone and 11-deoxycorticosterone and is restricted to the X-zone.

AKR1C1 AKR1C2 AKR1C3

1.01e-066130317122075
Pubmed

Decidual prolactin silences the expression of genes detrimental to pregnancy.

AKR1C1 AKR1C2 AKR1C3

1.01e-066130317255200
Pubmed

The proximal proteome of 17 SARS-CoV-2 proteins links to disrupted antiviral signaling and host translation.

VPS39 AHCTF1 SHB SCYL1 DNTTIP2 EHD4 IGF2R PDLIM3 TEX264 SIPA1L1 ZMAT2 EHD1 TMEM30A DNAJC1 PLK1 USP6NL

1.21e-0610071301634597346
Pubmed

The Steroidogenic Enzyme AKR1C3 Regulates Stability of the Ubiquitin Ligase Siah2 in Prostate Cancer Cells.

AKR1C1 AKR1C2 AKR1C3

1.77e-067130326160177
Pubmed

Aldo-ketoreductase 1c19 ablation does not affect insulin secretion in murine islets.

AKR1C1 AKR1C2 AKR1C3

1.77e-067130334843575
Pubmed

MicroRNA-200a serves a key role in the decline of progesterone receptor function leading to term and preterm labor.

AKR1C1 AKR1C2 AKR1C3

1.77e-067130322529366
Pubmed

A phosphodiesterase 11 (Pde11a) knockout mouse expressed functional but reduced Pde11a: Phenotype and impact on adrenocortical function.

AKR1C1 AKR1C2 AKR1C3

1.77e-067130333127481
Pubmed

Genetic variation in the progesterone receptor and metabolism pathways and hormone therapy in relation to breast cancer risk.

AKR1C1 AKR1C2 AKR1C3

1.77e-067130319846565
Pubmed

A cluster of eight hydroxysteroid dehydrogenase genes belonging to the aldo-keto reductase supergene family on mouse chromosome 13.

AKR1C1 AKR1C2 AKR1C3

1.77e-067130312562828
Pubmed

17Beta-HSD type 5 expression and the emergence of differentiated epithelial Type II cells in fetal lung: a novel role for androgen during the surge of surfactant.

AKR1C1 AKR1C2 AKR1C3

1.77e-067130316337335
Pubmed

Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.

VPS39 SYNE1 SMG5 BIRC6 PASK SIPA1L1 ANKRD28 USP15

2.24e-06225130812168954
Pubmed

Androgen Receptor Is Dispensable for X-Zone Regression in the Female Adrenal but Regulates Post-Partum Corticosterone Levels and Protects Cortex Integrity.

AKR1C1 AKR1C2 AKR1C3

2.82e-068130333584538
Pubmed

Naturally occurring variants of human aldo-keto reductases with reduced in vitro metabolism of daunorubicin and doxorubicin.

AKR1C1 AKR1C2 AKR1C3

2.82e-068130320837989
Pubmed

Cloning of mouse 17beta-hydroxysteroid dehydrogenase type 2, and analysing expression of the mRNAs for types 1, 2, 3, 4 and 5 in mouse embryos and adult tissues.

AKR1C1 AKR1C2 AKR1C3

2.82e-06813039224647
Pubmed

A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.

VWF SYNE1 SHB BIRC6 AKR1C2 DNTTIP2 ZBTB44 PDLIM3 ANKRD28 MYBPC1 PLCE1

2.87e-064971301123414517
Pubmed

Fetal onset of aberrant gene expression relevant to pulmonary carcinogenesis in lung adenocarcinoma development induced by in utero arsenic exposure.

AKR1C1 AKR1C2 IGF2R AKR1C3

3.06e-0627130417077188
Pubmed

Decrease in the T-box1 gene expression in embryonic brain and adult hippocampus of down syndrome mouse models.

AKR1C1 AKR1C2 AKR1C3

4.22e-069130333348080
Pubmed

Lack of placental neurosteroid alters cortical development and female somatosensory function.

AKR1C1 AKR1C2 AKR1C3

6.01e-0610130336313771
Pubmed

The endocytic recycling regulatory protein EHD1 Is required for ocular lens development.

EHD4 EHD3 EHD1

8.24e-0611130326455409
Pubmed

Endogenous biotin as a marker of adrenocortical cells with steroidogenic potential.

AKR1C1 AKR1C2 AKR1C3

1.10e-0512130321256921
Pubmed

Timing of adrenal regression controlled by synergistic interaction between Sf1 SUMOylation and Dax1.

AKR1C1 AKR1C2 AKR1C3

1.10e-0512130328893949
Pubmed

A Novel Population of Inner Cortical Cells in the Adrenal Gland That Displays Sexually Dimorphic Expression of Thyroid Hormone Receptor-β1.

AKR1C1 AKR1C2 AKR1C3

1.10e-0512130325774556
Pubmed

N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.

SIN3B RPL29 AHCTF1 SRCAP DNTTIP2 RASSF5 PDLIM3 MTHFD1 ZMAT2 TPX2 ANKRD28 SLFN11 SIPA1L2 PC

1.13e-059341301433916271
Pubmed

Eps15 Homology Domain Protein 4 (EHD4) is required for Eps15 Homology Domain Protein 1 (EHD1)-mediated endosomal recruitment and fission.

EHD4 EHD1

1.39e-052130232966336
Pubmed

The structure and expression of the human neuroligin-3 gene.

NLGN3 NLGN2

1.39e-052130210767552
Pubmed

Interactions of Prototype Foamy Virus Capsids with Host Cell Polo-Like Kinases Are Important for Efficient Viral DNA Integration.

PLK2 PLK1

1.39e-052130227579920
Pubmed

TPX2 promotes cell proliferation and migration via PLK1 in OC.

TPX2 PLK1

1.39e-052130229865033
Pubmed

Relationship of human liver dihydrodiol dehydrogenases to hepatic bile-acid-binding protein and an oxidoreductase of human colon cells.

AKR1C1 AKR1C2

1.39e-05213028573067
Pubmed

Structure of the human 3alpha-hydroxysteroid dehydrogenase type 3 in complex with testosterone and NADP at 1.25-A resolution.

AKR1C1 AKR1C2

1.39e-052130211514561
Pubmed

Novel dendritic kinesin sorting identified by different process targeting of two related kinesins: KIF21A and KIF21B.

KIF21B KIF21A

1.39e-052130210225949
Pubmed

EHD proteins are associated with tubular and vesicular compartments and interact with specific phospholipids.

EHD4 EHD1

1.39e-052130217097635
Pubmed

Distinct roles for extracellular and intracellular domains in neuroligin function at inhibitory synapses.

NLGN3 NLGN2

1.39e-052130227805570
Pubmed

Selective loss of AKR1C1 and AKR1C2 in breast cancer and their potential effect on progesterone signaling.

AKR1C1 AKR1C2

1.39e-052130215492289
Pubmed

Local androgen inactivation in abdominal visceral adipose tissue.

AKR1C2 AKR1C3

1.39e-052130214671194
Pubmed

AKR1C1 and AKR1C3 may determine progesterone and estrogen ratios in endometrial cancer.

AKR1C1 AKR1C3

1.39e-052130216338060
Pubmed

Pathophysiological roles of aldo-keto reductases (AKR1C1 and AKR1C3) in development of cisplatin resistance in human colon cancers.

AKR1C1 AKR1C3

1.39e-052130223165153
Pubmed

SPDEF enhances cancer stem cell-like properties and tumorigenesis through directly promoting GALNT7 transcription in luminal breast cancer.

GALNT7 SPDEF

1.39e-052130237633945
Pubmed

AKR1C2 and AKR1C3 expression in adipose tissue: Association with body fat distribution and regulatory variants.

AKR1C2 AKR1C3

1.39e-052130233675863
Pubmed

Renal thrombotic microangiopathy in mice with combined deletion of endocytic recycling regulators EHD3 and EHD4.

EHD4 EHD3

1.39e-052130221408024
Pubmed

SUMOylation of EHD3 Modulates Tubulation of the Endocytic Recycling Compartment.

EHD3 EHD1

1.39e-052130226226295
Pubmed

Transcriptomic Profiling Reveals AKR1C1 and AKR1C3 Mediate Cisplatin Resistance in Signet Ring Cell Gastric Carcinoma via Autophagic Cell Death.

AKR1C1 AKR1C3

1.39e-052130234830394
Pubmed

cDNA and deduced amino acid sequences of a human colon dihydrodiol dehydrogenase.

AKR1C1 AKR1C2

1.39e-05213028011662
Pubmed

Cadmium, cobalt and lead cause stress response, cell cycle deregulation and increased steroid as well as xenobiotic metabolism in primary normal human bronchial epithelial cells which is coordinated by at least nine transcription factors.

AKR1C1 AKR1C2

1.39e-052130218654764
Cytoband10p15-p14

AKR1C1 AKR1C2 AKR1C3

4.41e-076130310p15-p14
GeneFamilyAldo-keto reductases

AKR1C1 AKR1C2 AKR1C3

5.92e-0515943399
GeneFamilyArmadillo repeat containing|Protein phosphatase 1 regulatory subunits

LMTK2 PREX2 TMEM132C SACS TMEM132D ANKRD28

3.64e-04181946694
GeneFamilyDoublecortin superfamily

DCDC1 DCLK3

1.17e-03109421369
GeneFamilyKinesins|Pleckstrin homology domain containing

KIF21B KIF27 KIF21A

1.76e-0346943622
CoexpressionGSE5542_UNTREATED_VS_IFNG_TREATED_EPITHELIAL_CELLS_24H_UP

SYNE1 KIF21A GPR183 PLXND1 GTDC1 PNPLA6 SLFN11 DNAJC1

6.80e-061981308M6522
CoexpressionGSE17721_CTRL_VS_CPG_2H_BMDC_UP

NSUN4 SRCAP CPLX4 PNPLA6 TMEM30A ANKRD28 PACC1 ELAC1

7.32e-062001308M3759
CoexpressionGSE17721_LPS_VS_PAM3CSK4_12H_BMDC_UP

NSUN4 PLK2 EHD4 TPX2 MTMR2 AKR1C3 TMEM30A USP15

7.32e-062001308M3925
CoexpressionSERVITJA_ISLET_HNF1A_TARGETS_DN

PCSK1 DCT AKR1C1 AKR1C2 GRTP1 AKR1C3

3.20e-051211306MM935
CoexpressionBREDEMEYER_RAG_SIGNALING_NOT_VIA_ATM_UP

ZC4H2 AKR1C1 AKR1C2 EHD3 AKR1C3

3.40e-05741305MM769
CoexpressionGSE3982_BCELL_VS_NKCELL_DN

KIF21B SYNE1 PLEKHF1 AKR1C1 IGF2R TPX2 MAP2K7

5.90e-051971307M5548
CoexpressionGSE3982_DC_VS_BASOPHIL_DN

KIF21B PRSS2 SYNE1 AKR1C2 PASK NLGN3 AKR1C3

6.29e-051991307M5473
CoexpressionGSE11924_TH2_VS_TH17_CD4_TCELL_DN

NSUN4 VPS39 ZC4H2 SMYD2 MOB2 ZBTB44 MYO3A

6.49e-052001307M3165
ToppCellPND14-Endothelial-Endothelial_blood-vessel-Macrovascular_EC|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PLK2 VWF PLXND1 NXNL2 EHD4 MCTP1 PTPRR CAVIN1

6.84e-081831308fc9a7ba148c22d0c8a46f6bc56c772929ac496f7
ToppCellPND10-Endothelial-Endothelial_blood-vessel-Macrovascular_EC|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PLK2 VWF PLXND1 PREX2 EHD4 MCTP1 PTPRR CAVIN1

9.51e-081911308b270c3dd5952f56b9bdceabe13e298fe6757563b
ToppCellPND14-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

VWF PLXND1 NXNL2 PREX2 MCTP1 PTPRR CAVIN1

5.92e-0716613077a45785a40b7425f97be67bab1c5ceb69b2bd85a
ToppCellPND14-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_mature|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

VWF PLXND1 NXNL2 PREX2 MCTP1 PTPRR CAVIN1

5.92e-071661307bbd382812f8a84a5d99888de2d7cca3a8b5e4695
ToppCellCOVID-19-kidney-PEC|kidney / Disease (COVID-19 only), tissue and cell type

SYNE1 MYO3A PDLIM3 SACS SIPA1L2 BICC1 PLCE1

7.51e-07172130736a96714a0eb6ac438648135336c9791881ddadb
ToppCelldroplet-Kidney-KIDNEY-30m-Epithelial-Pecam____Kidney_cortex_artery_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

USP50 ADAMTSL1 VWF EPHA6 PLXND1 PTPRR CAVIN1

1.22e-061851307f98af3146ec2f44c30d31a662fb9c4fa3ca4f706
ToppCellfacs-Lung-Endomucin-3m-Endothelial|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DENND5B PLK2 VWF EHD4 GRTP1 MTMR2 CAVIN1

1.22e-061851307f262b441ea3fe7f69dff33d5f171000371f3a3e5
ToppCellP15-Endothelial-large_vessel_endothelial_cell-endothelial_cell_of_artery|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

PLK2 VWF PLXND1 NXNL2 MCTP1 PDLIM3 PTPRR

1.36e-06188130750b27fc12347ca16bd62333baf345c83cb422a8f
ToppCellE16.5-Endothelial-Endothelial_blood-vessel-Macrovascular_EC|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PLK2 VWF PLXND1 PREX2 EHD4 PTPRR CAVIN1

1.41e-061891307feedac2751ed770f80bc56fec31662b5b3826f58
ToppCellPND07-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_mature|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

DENND5B PLK2 VWF PLXND1 MCTP1 PTPRR CAVIN1

1.41e-0618913079da012fdfa9a8d488cab710a463a1d70e89f990c
ToppCell3'-GW_trimst-1-LargeIntestine-Endothelial-blood_vessel_EC-Mature_venous_EC|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PLK2 VWF PLXND1 EHD4 TPX2 CAVIN1 PLK1

1.41e-061891307b5fa3a619e3b554a1a45a551c9b6369075fe5615
ToppCellPND03-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PLK2 VWF PLXND1 PREX2 EHD4 PTPRR CAVIN1

1.46e-061901307d87b9e9ca863270a9c7f61674271a6440c97d1f4
ToppCellPND03-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC-VEC_mature|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

DENND5B PLK2 VWF ADAMTS5 EHD4 PTPRR CAVIN1

1.51e-061911307fcdf3a747038e346a467eae8b7c293592658b53f
ToppCellPND07-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

DENND5B PLK2 VWF PLXND1 MCTP1 PTPRR CAVIN1

1.51e-0619113073307dbccadb09c62b0e1c0235ec89bb294d748c3
ToppCellPND07-Endothelial-Endothelial_blood-vessel-Macrovascular_EC|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

DENND5B PLK2 VWF PLXND1 EHD4 PTPRR CAVIN1

1.51e-06191130727f23c2254b610abac1a88d0fecff305addde9da
ToppCellP07-Endothelial-large_vessel_endothelial_cell|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

PLK2 VWF PLXND1 EHD4 MCTP1 PTPRR EHD1

1.51e-061911307d162917816dd2e4767c97447c1cddae9397713ab
ToppCellPND03-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_mature|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PLK2 VWF PLXND1 PREX2 EHD4 PTPRR CAVIN1

1.57e-061921307285a9d332a1e07b94f222d4b518dd56928b9e075
ToppCellPND03-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

DENND5B PLK2 VWF ADAMTS5 EHD4 PTPRR CAVIN1

1.57e-061921307cd4c9b9ab17a779c154264f7459020f51e528ba5
ToppCell3'-GW_trimst-1-SmallIntestine-Endothelial-blood_vessel_EC-Mature_venous_EC|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PLK2 VWF PLXND1 EHD4 TPX2 CAVIN1 PLK1

1.62e-0619313071b69f92c6a7a2516e393d3f3c371407ec791343d
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

NDNF ADAMTS19 SYNE1 PDLIM3 KLK5 SIPA1L2 PLCE1

1.68e-0619413071374600957c7d7f0b05fd2c1186f521b9096d4ef
ToppCell5'-Parenchyma_lung-Endothelial-Blood_vessel_EC-vein_endothelial_cell-EC_venous_systemic-EC_venous_systemic_L.2.2.0.1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

PLK2 ADAMTSL1 VWF PREX2 EHD4 MCTP1 CAVIN1

1.80e-0619613075609b2d93172a488b35d854298a3a4e504e17e28
ToppCellIPF-Endothelial-VE_Peribronchial|Endothelial / Disease state, Lineage and Cell class

ADAMTSL1 VWF AHCTF1 PREX2 EHD4 MCTP1 ANKRD28

1.92e-061981307b8bd1ba268480f54451648e01631b615a3401144
ToppCellkidney_cells-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PLK2 VWF PLXND1 PREX2 EHD4 MCTP1 CAVIN1

1.99e-06199130733f1669eeb701986b4dec409efdb6c06c3c41c2b
ToppCellfacs-Pancreas-Exocrine-3m-Epithelial-nan|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PCSK1 PRSS2 NXNL2 TRPM3 PACC1 DTHD1

6.36e-061551306441fcb6d05364fc6f4973f0b973f1a80b573ce1f
ToppCelldroplet-Kidney-KIDNEY-30m-Lymphocytic-Epcam____proximal_tube_epithelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KIF21B PLK2 GPR183 SIPA1L2 USP15 USP6NL

7.10e-0615813061d78578dc1f8ba43dacdccae1082c0b9d749f64d
ToppCell10x5'-GI_large-bowel-Lymphocytic_T_CD4-Tfh|GI_large-bowel / Manually curated celltypes from each tissue

GPR183 PLXND1 METTL4 PASK ZBTB44 CAVIN1

8.49e-0616313064104d3b9748b39cb0744c9be76db21bdda566a0d
ToppCellfacs-Lung-18m-Hematologic-lymphocytic-regulatory_T_cell|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

PCSK1 PRSS2 GPR183 RASSF5 MYO3A ZC3H12D

1.01e-0516813062d2eab3190374f79f373e31c8b062ff4e1766396
ToppCellfacs-Lung-18m-Hematologic-lymphocytic-regulatory_T_cell-regulatory_T_cell|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

PCSK1 PRSS2 GPR183 RASSF5 MYO3A ZC3H12D

1.01e-051681306df58156721457b34af1e81c0eb8a7243cbbfb303
ToppCellCOVID-19-kidney-PEC|COVID-19 / Disease (COVID-19 only), tissue and cell type

DCDC1 MYO3A TRPM3 TMEM132D BICC1 PLCE1

1.01e-051681306a086c306be430adf0632ba53e98cd8014d2de330
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_ILC|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

SYNE1 KIF21A PLEKHF1 IGF2R AKR1C3 DTHD1

1.15e-05172130686f52f486d67217fc1b8443ab362c975df2974a4
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_ILC-NK_cell-NK_c01-FCGR3A|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

SYNE1 KIF21A PLEKHF1 IGF2R AKR1C3 DTHD1

1.15e-051721306fb2df8fea6df5947165f13978f1d1006d15b60fd
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_ILC-NK_cell|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

SYNE1 KIF21A PLEKHF1 IGF2R AKR1C3 DTHD1

1.15e-051721306e38ebb216e4ddcd008148fcbaf709b4f3c83706a
ToppCellE15.5-Endothelial-large_vessel_endothelial_cell-endothelial_cell_of_artery|E15.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

VWF PREX2 EHD4 PTPRR EHD1 CAVIN1

1.19e-051731306b0ff9808e38cb64a734ced498cd0546728746cd5
ToppCellE16.5-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PLK2 VWF PLXND1 PREX2 EHD4 PTPRR

1.31e-05176130677516048aefbe1f48e825052756df0c310c1c486
ToppCell356C-Myeloid-Macrophage-FABP4+_Macrophage_3|Macrophage / Donor, Lineage, Cell class and subclass (all cells)

IQCH PLEKHF1 ADAMTS5 MYO3A PDLIM3 BICC1

1.31e-051761306bfa1633e1b7a8a2f04d37fa07284fe9bc0199f46
ToppCellE16.5-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_mature|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PLK2 VWF PLXND1 PREX2 PTPRR EHD1

1.31e-05176130696779273b94345250cf53ba671203345b43d9e00
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-Adaptive_/_Maladaptive_/_Repairing_Fibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

NDNF ADAMTSL1 ADAMTS5 PREX2 TMEM132C PDLIM3

1.36e-0517713069ec7f1e64312d26d434b3312b58386715dbad644
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

NDNF ADAMTSL1 ADAMTS5 PREX2 TMEM132C PDLIM3

1.36e-051771306016277dfd59b1793fddaaadc2b3f41622d76ce3a
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-Degenerative_Endothelial_Cell-Degenerative_Peritubular_Capilary_Endothelial_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PLK2 VWF PLXND1 PREX2 EHD4 CAVIN1

1.49e-05180130616728b9a1c52097e3a460534be71a476ecc54f0f
ToppCellIIH-CD4-exh_CD4|IIH / Condition, Cell_class and T cell subcluster

PRSS2 KIF21A PLEKHF1 IDH2 RESF1 ANKRD28

1.49e-05180130631f22960819bfad79cbbd3b10c5dc46d7a47e340
ToppCellfacs-Lung-3m-Endothelial-venous_endothelial-vein_endothelial_cell-vein_endothelial_cell|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

DENND5B VWF EHD4 PTPRR CAVIN1 PLK1

1.54e-05181130672c28baf4fd417ff4a7068603830d55074960144
ToppCellPND10-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_mature|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PLK2 VWF PLXND1 PREX2 MCTP1 PTPRR

1.54e-0518113064d7793026373cbcf04b15c77f95f1025d07d4c00
ToppCellfacs-Lung-3m-Endothelial-venous_endothelial-vein_endothelial_cell|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

DENND5B VWF EHD4 PTPRR CAVIN1 PLK1

1.54e-0518113062ac4d3e8987d5a009d7908d8787e18165826202a
ToppCellfacs-Lung-3m-Endothelial-venous_endothelial|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

DENND5B VWF EHD4 PTPRR CAVIN1 PLK1

1.54e-0518113062628c7ac345eaaeecf8e34617e81948925962cb9
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2-Exc_L6_FEZF2_VWA2|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ADAMTS19 ADAMTSL1 EPHA6 SHB MCTP1 BICC1

1.59e-05182130672e65a23cd36085bc880087d3cae92395de918a1
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ADAMTS19 ADAMTSL1 EPHA6 SHB MCTP1 BICC1

1.59e-05182130605c167158815bf25d509df59ab386e1990712765
ToppCellPND10-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PLK2 VWF PLXND1 PREX2 MCTP1 PTPRR

1.64e-0518313063427f3cbe6ea81709750e7dd3ff378f03ae65eab
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L5_PVALB_CNTNAP3P2|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

EPHA6 ADAMTS5 GALNT7 TMEM132C SRL PLCE1

1.64e-051831306121791ef84e7ce377ed6f5b7953af8865e04958e
ToppCellfacs-Lung-Endomucin-3m|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PLK2 EHD4 GRTP1 MTMR2 CAVIN1 ALB

1.64e-0518313063dc6cbe803e5b8c4201faaf2e6445898d71684e6
ToppCellfacs-Lung-Endomucin-3m-Endothelial-Capillary_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PLK2 EHD4 GRTP1 MTMR2 CAVIN1 ALB

1.64e-0518313061e51aeaa8fc9383b424cce128a890e07cb6025f3
ToppCellFetal_29-31_weeks-Endothelial-endothelial_cell_of_vein-D150|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

PLK2 VWF EPHA6 PLXND1 PREX2 MCTP1

1.64e-051831306c1297d8eddfc7132e84ceef14f01b6281f9d0f6a
ToppCelldroplet-Trachea-nan-3m-Endothelial|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PLK2 VWF PLXND1 PREX2 EHD4 PTPRR

1.69e-051841306fa5c3020e75fdde1363393dea97ebd99f1eae9ff
ToppCellLPS-IL1RA|World / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

VWF EHD3 RESF1 MCTP1 SIPA1L2 USP15

1.69e-051841306c066c2ec4f0f1d6eb183fca5c7bb0cd45c9950dc
ToppCelldroplet-Trachea-3m-Endothelial|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

PLK2 VWF PLXND1 PREX2 EHD4 PTPRR

1.69e-051841306ad520ab6bb776b5303df505b7e1afb22484f18a7
ToppCell3'-Broncho-tracheal-Immune_Myeloid-Myeloid_macrophage-elicited_macrophage-Monocyte-derived_macrophage-Monocyte-derived_macrophage_L.1.2.5.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

GPR183 DNTTIP2 ACOD1 SIPA1L1 EHD1 LRIF1

1.69e-051841306d1ea2b60fb1ca1a0b809d131310c43903a9e84ce
ToppCelldroplet-Trachea-nan-3m-Endothelial-nan|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PLK2 VWF PLXND1 PREX2 EHD4 PTPRR

1.69e-0518413061d63cb75a89c5f3f3b9ebf7fce8cb0fd4a92b645
ToppCellEndothelial-E|World / shred on cell class and cell subclass (v4)

PLK2 VWF PLXND1 EHD4 PTPRR CAVIN1

1.69e-051841306b4c561924c508536fd2112e91e32176b95fdf63a
ToppCelldroplet-Trachea-nan-3m-Endothelial-endothelial_cell|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PLK2 VWF PLXND1 PREX2 EHD4 PTPRR

1.69e-05184130676caad53d55fff5acca27bf190a6de7b27437d9f
ToppCelldroplet-Trachea-3m-Endothelial-endothelial_cell_of_trachea|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

PLK2 VWF PLXND1 PREX2 EHD4 PTPRR

1.69e-0518413061fc1f0a3b4dbb085ebcc3960f67be24a108fe5b9
ToppCelldroplet-Trachea-3m-Endothelial-endothelial_cell_of_trachea-tracheal_endothelial_cell|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

PLK2 VWF PLXND1 PREX2 EHD4 PTPRR

1.69e-0518413062467207aaea307873ab286f89cfc7668a227a694
ToppCellP28-Endothelial-large_vessel_endothelial_cell-endothelial_cell_of_artery|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

PLK2 VWF PLXND1 NXNL2 MCTP1 PDLIM3

1.69e-0518413068ed22b1af04a711203293e7a8b3df6fb9222fad5
ToppCell3'-GW_trimst-2-LargeIntestine-Endothelial-blood_vessel_EC-venous_capillary|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

VWF PLXND1 EHD4 ADAD2 MCTP1 SLFN11

1.74e-051851306a987dbf6adf533c5f8a0a8a465a6c8e67e0ffcc8
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

DCDC1 SYNE1 DNAH14 TRPM3 TMEM132D BICC1

1.80e-051861306f0c8de4f6ae9047b9108a47a2af8c5f42bc103b0
ToppCelldroplet-Lung-LUNG-30m-Endothelial-Capillary_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PLK2 VWF SYNE1 EHD4 GRTP1 CAVIN1

1.85e-05187130652ffd4be374e329ac8d321063f061b826d252956
ToppCellfacs-Lung-3m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell-pulmonary_artery_endothelial_cell_l25|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

VWF PLXND1 MCTP1 PDLIM3 PTPRR CAVIN1

1.85e-0518713067170694a1b86fe8d84d96c880ffe57af09bdc026
ToppCellLPS-IL1RA-Stromal_mesenchymal-Lung_smooth_muscle-Myofibroblast|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

SYNE1 ADAMTS5 TMEM132C PDLIM3 NLGN2 BICC1

1.91e-0518813063177b2c1723268d330d3e9f24f9e24492ace6286
ToppCellP07-Endothelial-large_vessel_endothelial_cell-endothelial_cell_of_artery|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

VWF PLXND1 PREX2 MCTP1 PTPRR EHD1

1.91e-0518813065bc1537e079c7435196c163bff5f639ea392a33a
ToppCellEndothelial-Endothelial-E|Endothelial / shred on cell class and cell subclass (v4)

VWF ADAMTS5 PLXND1 EHD4 PDLIM3 PTPRR

1.91e-0518813062777eb7689b271c199021fe7d9db88ccebff14de
ToppCell3'-GW_trimst-2-LargeIntestine-Endothelial-blood_vessel_EC-cycling_EC|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

DRC7 VWF PLXND1 EHD4 ADAD2 TPX2

1.91e-0518813065d166d9e71632edd059ff0a9f66f8763f259d40a
ToppCellP28-Endothelial-large_vessel_endothelial_cell|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

VWF PLXND1 EHD4 MCTP1 PDLIM3 PTPRR

1.91e-051881306263169029293e005bcffd87db20221fdd2d3917e
ToppCellE18.5-Endothelial-Endothelial_blood-vessel-Macrovascular_EC|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PLK2 VWF PLXND1 PREX2 EHD4 PTPRR

1.97e-051891306d17e8467699c7ca7694a313c26111f085df5204e
ToppCellCOVID-19_Severe-HSPC|COVID-19_Severe / disease group, cell group and cell class

PRSS2 PREX2 DNAH14 NYNRIN AKR1C3 CAVIN1

1.97e-05189130696015439971e2e5b8d6294ca5a6b873c7774e925
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

DCDC1 EPHA6 NXNL2 MYO3A TRPM3 BICC1

1.97e-05189130628b502611829e4a24caff2562545c7db97686099
ToppCellE17.5-Endothelial-large_vessel_endothelial_cell|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

PLK2 VWF PREX2 EHD4 PTPRR EHD1

1.97e-051891306360f09f46231a83f99d8fa0158b72a38068e1642
ToppCellPND01-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_mature|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

VWF PLXND1 EHD4 MCTP1 PTPRR CAVIN1

2.02e-051901306eae5bcdb8a35f3fba4d25854c1a43f83f80832a2
ToppCell10x_3'_v2v3-Non-neoplastic-Glial-Neuronal-OPC-OPC-G|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

AKR1C1 EHD3 TMEM132C NLGN3 TMEM132D AKR1C3

2.02e-0519013066c7e1086c0a274cd5527c3104106e372811c9905
ToppCell(4)_Endothelial_cells-(40)_EC-arterial|(4)_Endothelial_cells / Cell class and subclass of bone marrow stroma cells in homeostatis

VWF SYNE1 EHD4 MCTP1 PDLIM3 CAVIN1

2.02e-051901306ff774faf3f12759d11e50ed7d189288bb79e22e1
ToppCellPND01-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

VWF PLXND1 EHD4 MCTP1 PTPRR CAVIN1

2.02e-0519013063346bfd0474828b3729cffa9f4cc57b04dd30443
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

DCDC1 AKR1C1 DNAH14 TMEM132D BICC1 ADGRA3

2.09e-051911306d0e9afe7b6334dd515d3e68892efdc76347a55e5
ToppCellfacs-Lung-3m-Endothelial-arterial_endothelial|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

VWF PLXND1 NXNL2 PDLIM3 PTPRR CAVIN1

2.09e-0519113066e6b2cb390cc5cd0356924a2c36fbe5b5bd5966c
ToppCellfacs-Lung-3m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

VWF PLXND1 NXNL2 PDLIM3 PTPRR CAVIN1

2.09e-051911306482db995930346be69072ace2fd78fd453e97fb5
ToppCellCOVID-19-Heart-EC_(POSTN)|Heart / Disease (COVID-19 only), tissue and cell type

ADAMTSL1 VWF TMEM132C TRPM3 SIPA1L1 AKR1C3

2.15e-051921306c0c34785a7bdf461722029b322e9184e3d9b3c26
ToppCell5'-Adult-Distal_Rectal-Endothelial-blood_vessel_EC-Mature_venous_EC|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

VWF PLXND1 PREX2 ADAD2 MCTP1 CAVIN1

2.15e-051921306eafead22bba48ac5ee568faa8946c444445c1034
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Ascending_Vasa_Recta_Endothelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PLK2 ADAMTSL1 VWF PLXND1 PREX2 EHD4

2.15e-0519213061ee4783051ec94ea94600f040edcb385fc4289f1
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

RPL29 PLK2 FAM111B MYO3A EHD1 TPX2

2.15e-051921306b18ae7337eaad1315a5b0ee81c75f7606bd3c7fe
ToppCell390C-Epithelial_cells-Epithelial-G_(Club-Clara_cells)|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

PLK2 AKR1C1 AKR1C2 NYNRIN AKR1C3 SIPA1L2

2.15e-0519213065d24bb6c6c17a6b803b241d065b31896a7d86c37
ToppCell3'-GW_trimst-1-LargeIntestine-Endothelial-blood_vessel_EC-Fetal_arterial_EC|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PLK2 VWF PLXND1 PREX2 ADAD2 CAVIN1

2.15e-0519213061f35efb0765e05f7f9c881849953bef3965be25a
ToppCell390C-Epithelial_cells-Epithelial-G_(Club-Clara_cells)-|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

PLK2 AKR1C1 AKR1C2 NYNRIN AKR1C3 SIPA1L2

2.15e-051921306c6795ceba90f1a5d441dff92a737b9c7d28b06b0
ToppCellLPS-IL1RA+antiTNF-Endothelial-Endothelial-Gen_Cap|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PLK2 VWF PREX2 MCTP1 PRKCE SIPA1L2

2.21e-051931306e09387af84d2a0a526e54d4793e6e06c6739db53
ToppCell3'-Distal_airway-Endothelial-Blood_vessel_EC-pulmonary_artery_endothelial_cell-EC_arterial-EC_arterial_L.2.4.0.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

VWF PREX2 EHD4 MCTP1 PTPRR CAVIN1

2.21e-0519313061e6e2d786511cc40241197368f5df20c20b882f3
ToppCell5'-GW_trimst-2-SmallIntestine-Mesenchymal-stromal_related|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ADAMTSL1 ZSWIM5 TMEM132C PDLIM3 TMEM132D PLCE1

2.21e-051931306f27e2be497745098b5269aa799dd3d5f62d78ba7
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

PLK2 PLXND1 PREX2 MCTP1 ANKRD28 CAVIN1

2.21e-051931306cc355b2ed6510619cad969ae074126d7c8db784d
ToppCelldroplet-Liver-LIVER_HEP-30m-Endothelial-endothelial_cell_of_hepatic_sinusoid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PLXND1 PREX2 EHD3 PTPRR NYNRIN CAVIN1

2.21e-051931306d485634c564b268e344b6a2863c26f6adaec9e38
ToppCellP15-Endothelial-large_vessel_endothelial_cell|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

VWF PLXND1 MCTP1 PDLIM3 PTPRR CAVIN1

2.21e-0519313065f9a7cd5f8eb9ac294cdb50518fedf872f3f78f5
ToppCellPSB-critical-LOC-Epithelial-FOXN4+|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

FAM111B MYO3A TCHH TPX2 SLFN11 PLCE1

2.21e-051931306b7d9c5bed524423e92f01496a9f8fad11b33a3f7
ToppCellPND03-Endothelial-Endothelial_blood-vessel-Macrovascular_EC|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PLK2 VWF PLXND1 EHD4 PTPRR CAVIN1

2.21e-05193130658c590dd6f21bc7ae58ae1729dd574c0f1069592
ToppCell5'-GW_trimst-2-SmallIntestine-Mesenchymal-stromal_related-ICC|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ADAMTSL1 ZSWIM5 TMEM132C PDLIM3 TMEM132D PLCE1

2.21e-0519313064ccf984baebbb13ae916727137ce593fda7514a2
ToppCellfacs-Kidney-nan-3m-Endothelial|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PLK2 PLXND1 PREX2 EHD4 EHD3 CAVIN1

2.28e-0519413065fa2dfca32cca4abfda0af90b83f2b2a826f9b6e
ToppCellMS-CD8|MS / Condition, Cell_class and T cell subcluster

SYNE1 KIF21A PLEKHF1 IDH2 RESF1 DTHD1

2.28e-0519413068dfeaa213403cedecb1976bfde1bac84f0155999
ToppCellfacs-Kidney-nan-3m-Endothelial-fenestrated_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PLK2 PLXND1 PREX2 EHD4 EHD3 CAVIN1

2.28e-05194130604df35246287815bdd28adaf885bdb98cf49524e
Drugzomepirac

AKR1C1 AKR1C2 AKR1C3 ALB

3.50e-0871304ctd:C020549
Drugcyclopentanol

AKR1C1 AKR1C2 AKR1C3

1.82e-0731303ctd:C016327
Drugcyclopentanone

AKR1C1 AKR1C2 AKR1C3

1.82e-0731303ctd:C007201
Drug4-benzoylbenzoic acid

AKR1C1 AKR1C2 AKR1C3

1.82e-0731303ctd:C058818
Drugdichloro(4-cymene)ruthenium(II)

AKR1C1 AKR1C2 AKR1C3

1.82e-0731303ctd:C530610
Drugcloxazolam

AKR1C1 AKR1C2 AKR1C3

7.25e-0741303ctd:C005522
DrugPregnanes

AKR1C1 AKR1C2 AKR1C3

7.25e-0741303ctd:D011278
Drugtetralol

AKR1C1 AKR1C2 AKR1C3

7.25e-0741303ctd:C019106
Druggliquidone

AKR1C1 AKR1C2 AKR1C3

7.25e-0741303ctd:C010969
Drug3',3'',5',5''-tetrabromophenolphthalein

AKR1C1 AKR1C2 AKR1C3

7.25e-0741303ctd:C018156
DrugHydroxysteroids

AKR1C1 AKR1C2 AKR1C3

1.80e-0651303ctd:D006914
DrugNSC86000

AKR1C1 AKR1C2 AKR1C3

1.80e-0651303CID000257630
Drugcresolphthalein

AKR1C1 AKR1C2 AKR1C3

1.80e-0651303ctd:C010092
DrugEstazolam

AKR1C1 AKR1C2 AKR1C3

3.59e-0661303ctd:D004949
DrugGlipizide

AKR1C1 AKR1C2 AKR1C3

3.59e-0661303ctd:D005913
Drugacenaphthene-1-ol

AKR1C1 AKR1C2 AKR1C3

3.59e-0661303ctd:C023723
DrugMedazepam

AKR1C1 AKR1C2 AKR1C3

3.59e-0661303ctd:D008472
Drug4-hydroxyequilenin-o-quinone

AKR1C1 AKR1C2 AKR1C3

6.26e-0671303ctd:C117714
Drugbenzene dihydrodiol

AKR1C1 AKR1C2 AKR1C3 SYMPK

6.85e-06221304CID000000418
Drug2'-Monophosphoadenosine 5'-Diphosphoribose

AKR1C1 AKR1C2 MTHFD1 AKR1C3

8.26e-06231304DB03461
DrugGlycyrrhetinic Acid

AKR1C1 AKR1C2 AKR1C3 ALB

9.87e-06241304ctd:D006034
DrugNitrazepam

AKR1C1 AKR1C2 AKR1C3

9.98e-0681303ctd:D009567
Drug4-hydroxybenzoic acid

AKR1C1 AKR1C2 AKR1C3

1.49e-0591303ctd:C038193
Drug20-alpha-Dihydroprogesterone

AKR1C1 AKR1C2 AKR1C3

1.49e-0591303ctd:D004092
Drugoctyl gallate

AKR1C1 AKR1C2 AKR1C3

2.12e-05101303ctd:C016627
DrugDihydroxydihydrobenzopyrenes

AKR1C1 AKR1C2 AKR1C3

2.90e-05111303ctd:D004101
Drugchlordecone alcohol

AKR1C1 AKR1C2 AKR1C3

2.90e-05111303CID000013946
Drugalpha-methylcinnamic acid

AKR1C1 AKR1C3

3.24e-0521302ctd:C510582
Drug(10ALPHA,13ALPHA,14BETA,17ALPHA)-17-HYDROXYANDROST-4-EN-3-ONE

AKR1C1 AKR1C2

3.24e-0521302DB07768
Drugbaccharin

AKR1C2 AKR1C3

3.24e-0521302ctd:C012764
Drugfenamic acid

AKR1C1 AKR1C2 AKR1C3

3.85e-05121303ctd:C001209
Drugmethylparaoxon

AKR1C1 AKR1C2 ALB

3.85e-05121303ctd:C008480
DrugPhenolphthalein

AKR1C1 AKR1C2 AKR1C3

3.85e-05121303ctd:D020113
DrugDMBA-3,4-dihydrodiol

AKR1C1 AKR1C2 AKR1C3

4.99e-05131303CID000050096
Drugflunisolide

AKR1C1 AKR1C2 AKR1C3

4.99e-05131303ctd:C007734
DrugDydrogesterone

AKR1C1 AKR1C2 AKR1C3

6.32e-05141303ctd:D004394
Drug5-alpha-Dihydroprogesterone

AKR1C1 AKR1C2 AKR1C3

6.32e-05141303ctd:D043582
Drug1-acenaphthenol

AKR1C1 AKR1C2 AKR1C3

6.32e-05141303CID000022750
DrugMeclofenamic Acid

AKR1C1 AKR1C2 AKR1C3

6.32e-05141303ctd:D008469
DrugMefenamic Acid

AKR1C1 AKR1C2 AKR1C3 ALB

7.15e-05391304ctd:D008528
Drugo-quinone

DCT AKR1C1 AKR1C2 AKR1C3

8.72e-05411304CID000011421
Drug17-AAG; Down 200; 1uM; MCF7; HT_HG-U133A

PLXND1 PASK TCHH EHD1 SPDEF CAVIN1 SYMPK

9.51e-0518513075585_DN
Drughexyl 2,5-dichlorophenylphosphoroamidate

PNPLA6 ALB

9.67e-0531302ctd:C066606
Drug5-dihydrodeoxycorticosterone

AKR1C1 AKR1C2

9.67e-0531302ctd:C454687
DrugDisulfiram [97-77-8]; Up 200; 13.4uM; PC3; HT_HG-U133A

PCSK1 SYNE1 SRCAP DCT PTPRR PACC1 C8B

1.16e-0419113075729_UP
Drugbenzo(a)pyrene-1,6-quinone

AKR1C1 AKR1C2 AKR1C3

1.17e-04171303ctd:C030233
DrugRemoxipride Hydrochloride [73220-03-8]; Up 200; 9.8uM; HL60; HT_HG-U133A

DENND5B SHB SRCAP PREX2 TCHH SPDEF USP6NL

1.32e-0419513073124_UP
DrugAsiaticoside [16830-15-2]; Down 200; 4.2uM; MCF7; HT_HG-U133A

SHB PLXND1 PASK GRTP1 AP1G2 PC SYMPK

1.32e-0419513073504_DN
DrugCisapride [81098-60-4]; Up 200; 8.6uM; MCF7; HT_HG-U133A

KIF21B VPS39 SMG5 IDH2 KCNN1 CAVIN1 SYMPK

1.32e-0419513075305_UP
DrugFluorometholone [426-13-1]; Up 200; 10.6uM; MCF7; HT_HG-U133A

DENND5B KIF21B SRCAP DCT PDLIM3 EHD1 C8B

1.32e-0419513076071_UP
Drugcloxazolam

AKR1C1 AKR1C2 AKR1C3

1.39e-04181303CID000002816
DrugRuthenium Compounds

AKR1C1 AKR1C2 AKR1C3

1.39e-04181303ctd:D017975
Drugbenzo(a)pyrene-3,6-quinone

AKR1C1 AKR1C2 AKR1C3

1.39e-04181303ctd:C018003
DrugAntipyrine, 4-hydroxy [1672-63-5]; Up 200; 19.6uM; HL60; HG-U133A

GPR183 EHD1 MTMR2 KCNN1 AP1G2 DNAJC1 KLK5

1.41e-0419713071997_UP
DrugEthionamide [536-33-4]; Up 200; 24uM; HL60; HT_HG-U133A

NDNF PLEKHF1 EHD3 TRPM3 AP1G2 ELAC1 PLCE1

1.45e-0419813072495_UP
DrugSulfamethoxypyridazine [80-35-3]; Down 200; 14.2uM; PC3; HT_HG-U133A

SYNE1 PASK GRTP1 BTD EHD1 BICC1 SYMPK

1.45e-0419813073711_DN
DrugBisoprolol fumarate; Up 200; 9uM; PC3; HT_HG-U133A

KIF21B NDNF LMTK2 SMG5 PASK PDLIM3 PRKCE

1.45e-0419813076748_UP
DrugPridinol methanesulfonate salt [6856-31-1]; Down 200; 10.2uM; HL60; HT_HG-U133A

SYNE1 SHB PREX2 EHD3 SIPA1L1 PACC1 DNAJC1

1.50e-0419913072715_DN
Drugoxcarbazepine

AKR1C1 AKR1C2 AKR1C3

1.65e-04191303ctd:C036006
DrugCAS 68-19-9

IGF2R MTHFD1 BTD PRKCE ALB ELAC1

1.88e-041451306CID000002891
Drugcopper carbonate

SACS PC

1.93e-0441302CID000014452
Drugtorquatone

PRSS2 ALB

1.93e-0441302CID000256516
Drugbisnorbiotin

BTD PC

1.93e-0441302CID000086492
Drug6,8-dimethylergoline

AKR1C2 TMEM132D

1.93e-0441302CID000100077
Drugpalmityl phosphonoformate

TMEM132D ALB

1.93e-0441302CID000452312
Drugtetrahydrodeoxycorticosterone

AKR1C1 AKR1C2

1.93e-0441302ctd:C009413
Drug1,7-octadiene

VWF SYNE1

1.93e-0441302CID000019460
DrugDBD-H

AKR1C1 AKR1C3

1.93e-0441302CID000131382
Drugbenzo(a)pyrene-7,8-dione

AKR1C1 AKR1C2 AKR1C3

1.93e-04201303ctd:C076588
DrugChrysenes

AKR1C1 AKR1C2 AKR1C3

1.93e-04201303ctd:D002911
Drug6-nitrotryptophan

PRSS2 ALB PC

1.93e-04201303CID000600156
DrugFlunitrazepam

AKR1C1 AKR1C2 AKR1C3

2.24e-04211303ctd:D005445
Drugconiferaldehyde

AKR1C1 AKR1C2 AKR1C3

2.24e-04211303ctd:C075384
DrugDutasteride

AKR1C1 AKR1C2 AKR1C3

2.24e-04211303ctd:D000068538
DiseaseNeoplasms, Hormone-Dependent

AKR1C1 AKR1C2 AKR1C3

8.16e-0831293C0027661
DiseaseHermaphroditism

AKR1C1 AKR1C2 AKR1C3

8.11e-0751293C0019269
DiseaseAmbiguous Genitalia

AKR1C1 AKR1C2 AKR1C3

8.11e-0751293C0266362
DiseasePseudohermaphroditism

AKR1C1 AKR1C2 AKR1C3

8.11e-0751293C0033804
DiseaseIntersex Conditions

AKR1C1 AKR1C2 AKR1C3

8.11e-0751293C2930618
DiseaseSex Differentiation Disorders

AKR1C1 AKR1C2 AKR1C3

8.11e-0751293C2930619
DiseaseDisorders of Sex Development

AKR1C1 AKR1C2 AKR1C3

2.82e-0671293C0036875
Diseaseaortic measurement

PCSK1 DCDC1 PTPRR SRL PRKCE USP15 PLCE1

1.23e-042511297EFO_0020865
Diseaseplatelet component distribution width

CAPN14 VWF NUP210L SYNE1 EHD3 GRTP1 TRPM3 NYNRIN ANKRD28 CAVIN1 USP15 MYBPC1

1.23e-0475512912EFO_0007984
Diseaseimmature platelet fraction

VWF EHD3 RASSF5 GRTP1 TRPM3

1.48e-041141295EFO_0009187
Diseaseimmature platelet measurement

VWF EHD3 RASSF5 GRTP1 TRPM3

1.81e-041191295EFO_0803541
Diseasenephrotic syndrome (is_implicated_in)

ALB PLCE1

1.88e-0451292DOID:1184 (is_implicated_in)
Diseasecortolone glucuronide (1) measurement

AKR1C2 AKR1C3

2.81e-0461292EFO_0800552
Diseaseascending aortic diameter

PCSK1 DCDC1 PTPRR USP15 PLCE1

3.84e-041401295EFO_0021787
Diseasetestosterone measurement

DAGLB PCSK1 POLR1A KIF27 DCDC1 SRCAP DCT BIRC6 AKR1C2 TEX264 MTHFD1 NYNRIN AKR1C3 NLGN2 MAP2K7

4.67e-04127512915EFO_0004908
Diseaseshoulder impingement syndrome

PDLIM3 SIPA1L2 USP6NL

5.24e-04361293EFO_1001178
Diseasemean platelet volume

DAGLB VWF NUP210L PLXND1 SRCAP EHD3 RASSF5 GRTP1 TRPM3 BTD ANKRD28 CAVIN1 PLCE1

5.43e-04102012913EFO_0004584
Diseasecentronuclear myopathy X-linked (implicated_via_orthology)

MTMR7 MTMR2

6.69e-0491292DOID:0111225 (implicated_via_orthology)
DiseaseX-18913 measurement

BTD ANKRD28

1.02e-03111292EFO_0800795
Diseaseimmature platelet count

VWF EHD3 GRTP1 TRPM3

1.23e-031061294EFO_0803544
Diseasedevelopmental disorder of mental health (implicated_via_orthology)

SIN3B PLXND1 SRCAP

1.30e-03491293DOID:0060037 (implicated_via_orthology)
DiseasePR interval

METTL4 MYO3A TRPM3 SIPA1L1 SRL GJB7 NUDCD1 SIPA1L2

1.54e-034951298EFO_0004462
Diseasemonocyte count

DAGLB PLK2 CYP8B1 PREX2 EHD4 EHD3 RASSF5 TPX2 SPDEF PRKCE PACC1 DTHD1 MYBPC1 PLCE1

1.94e-03132012914EFO_0005091
Diseasepre-eclampsia (is_marker_for)

ISCU AKR1C3 ALB

2.11e-03581293DOID:10591 (is_marker_for)
Diseaseresponse to methotrexate

AKR1C1 AKR1C2

2.19e-03161292GO_0031427
Diseasecup-to-disc ratio measurement

ADAMTS19 ADAMTSL1 DCDC1 CPLX4 BICC1 PLCE1 SYMPK

2.90e-034301297EFO_0006939
Diseaseresponse to methotrexate, neurotoxicity

DCT PNPLA6

3.09e-03191292EFO_0011057, GO_0031427
Diseaseresponse to COVID-19 vaccine, SARS-CoV-2 neutralizing antibody measurement

LMTK2 CPLX4

3.42e-03201292EFO_0803359, EFO_0803362
Diseasenucleotide measurement

GTDC1 PRKCE SIPA1L2

4.06e-03731293EFO_0010513
Diseasecholangiocarcinoma (is_implicated_in)

PREX2 ALB

4.14e-03221292DOID:4947 (is_implicated_in)

Protein segments in the cluster

PeptideGeneStartEntry
IPRARGHVKEIYKLV

ADAD2

246

Q8NCV1
RHPDYSVVLLLRLAK

ALB

361

P02768
RLPGYAEVLLKERKH

BIRC6

4166

Q9NR09
KLRKSFTPDHVVYAR

CAVIN1

296

Q6NZI2
KKHKRTPALIALRYQ

AKR1C3

246

P42330
FAVKHARYTLKPLLR

ADAMTS5

156

Q9UNA0
LSIFIQLKRHPERKY

ADGRA3

936

Q8IWK6
NKAPLRLKLRLTYDH

AP1G2

751

O75843
VKDYILKRTPIHAAA

ANKRD28

611

O15084
KRIRLGRKYVISHKE

ACOT12

321

Q8WYK0
TIKELRRANHVSYKP

BICC1

771

Q9H694
CKPLILRSKRYVHLG

BBS10

371

Q8TAM1
IRKAYRKLSLTLHPD

DNAJC1

81

Q96KC8
IRKVTCKHRPEYLVK

CAPN14

261

A8MX76
YTGFIKVHLKLRRPV

RASSF5

236

Q8WWW0
RIKVVEEKPAHSYLA

ADAMTS19

816

Q8TE59
KRTEVGLRIHIEKYL

IQCH

51

Q86VS3
RELSAPARLYHKKVV

ISCU

26

Q9H1K1
IKRDILRGKSVPHYA

NUDCD1

221

Q96RS6
ERKAYLEPEHTKARI

MOB2

21

Q70IA6
PAKLHELYEKVFSRR

PNPLA6

946

Q8IY17
RHKLQPRVIKVTAYK

DCDC1

166

M0R2J8
VGYLRLKDIIHRDIK

PASK

1116

Q96RG2
KRYSPLRIFHNLKDV

MCTP1

611

Q6DN14
HNAPRKVTAVIYARK

LRIF1

486

Q5T3J3
HDVYISLIRLARPVK

MTMR7

91

Q9Y216
EKRILALARKHPYLT

PRKCE

456

Q02156
YKHTRLVKKPDQARV

KCNN1

406

Q92952
SRLLVVDPKKRYTAH

DCLK3

591

Q9C098
VAIPYGSRHIRLVLK

ADAMTSL1

206

Q8N6G6
RKSSHIPYRDAKITR

KIF27

286

Q86VH2
RQSHRKKVLPEIYLT

PLXND1

1691

Q9Y4D7
RKRPKYNKLLEHSFI

MAP2K7

366

O14733
KVVHVPYRDSKLTRL

KIF21B

316

O75037
LGRHVYSRPKVDIQK

NDNF

276

Q8TB73
EPIHNRYKELLAKRA

MTMR2

591

Q13614
KRPAAEDVHRLLTYL

LMTK2

396

Q8IWU2
IKRARLAKVHAYIIS

EHD4

301

Q9H223
KKVFRVRLGHYSLSP

KLK5

111

Q9Y337
VDLATVPRRHRYKKK

NSUN4

16

Q96CB9
DIPRHGTKNRYKTIL

PTPRR

411

Q15256
YRTITDFREKLKHPV

PACC1

86

Q9H813
IGLKPRVRDHYRATK

NLGN3

606

Q9NZ94
ACLRVHLREKYRLPK

CPLX4

71

Q7Z7G2
RRHYADKRIKVAKPV

IDH2

36

P48735
RILRVVAHCNKPKYK

DAGLB

511

Q8NCG7
TVHSVIKRTPRKYLA

GALNT7

226

Q86SF2
PLHLNKRYGAVIKRL

GALNT8

46

Q9NY28
RRNKFKYLIDHPVSL

AXDND1

106

Q5T1B0
IKFVKPFVHLIRRAI

COL6A5

2481

A8TX70
VKRYVRKGVPLEHRA

GRTP1

61

Q5TC63
LRRTFKSKVLAHYPQ

DENND5B

51

Q6ZUT9
FDPAIRVLRDYKVKH

BTD

251

P43251
RVLRDYKVKHVVYPT

BTD

256

P43251
KDYTLIFHLQRKPRL

DTHD1

581

Q6ZMT9
KLYRLIERKSDLHPT

TMEM30A

271

Q9NV96
DDTTHFKLPKYRRLL

DNAH14

406

Q0VDD8
RLNRHKELAPLKYLA

DRC7

841

Q8IY82
LRKLSKPVYLRSHDE

LYRM1

106

O43325
RKHLVAERALLPTDY

ACOD1

291

A6NK06
REKRHRKKLYVSPGT

GJB7

101

Q6PEY0
ILDQYGKILPRVHRK

AHCTF1

996

Q8WYP5
SHYIKDKTRQTIPRI

FAM111B

331

Q6SJ93
RPDIIRKHLYKGEIA

GTDC1

421

Q4AE62
DLIKRARLAKVHAYI

EHD1

296

Q9H4M9
LGAVPKRHKALERYA

SACS

2496

Q9NZJ4
KEKQYLHIGLKPRVR

NLGN2

576

Q8NFZ4
ERLKHRPDGKYVVVT

MTHFD1

361

P11586
RSDLEVAHYKLKPRS

C8B

296

P07358
RQKHLRFIKEELYPS

METTL4

331

Q8N3J2
LYLLKHPEAIRAVRE

CYP8B1

296

Q9UNU6
VRIHEPFYKKVAAAL

NUP210L

231

Q5VU65
HQRPEETYKKLRLLG

NYNRIN

1556

Q9P2P1
KPATKYVFHIRVRTA

EPHA6

506

Q9UF33
RHKAYERKLGKVAPT

CWH43

411

Q9H720
KKRYDLSALVRHAEP

IGF2R

481

P11717
KRKYRSQHIIPLEEV

PLEKHF1

71

Q96S99
RKLDRLAYIAHPKLG

RPL29

91

P47914
LAYIAHPKLGKRARA

RPL29

96

P47914
ARILPEEKVLRLHYA

POLR1A

566

O95602
VRYISPKHRLIKVES

SHB

176

Q15464
SEPEAKVLHTKRLYR

SMG5

11

Q9UPR3
KVLHTKRLYRAVVEA

SMG5

16

Q9UPR3
GRVERYHKKLIRLPL

SYNE1

8201

Q8NF91
LKAHILRDKVYLSRP

TMEM132C

131

Q8N3T6
AHILRDKVYLSRPKV

TMEM132D

131

Q14C87
KRFKTLRHPNILAYI

SCYL1

66

Q96KG9
QRIIPLKALKRGYRH

PLCE1

1951

Q9P212
SRILTPKEYLQRQKH

RESF1

1441

Q9HCM1
PLRYNKIKRIEHAKG

GPR183

136

P32249
PKENLVLHLDRVKRY

SIPA1L1

466

O43166
PIHREKVKRYIIEHI

SIPA1L2

466

Q9P2F8
KIKTRFLDHPEIYRS

SIN3B

171

O75182
RRKIEQAIYKLPCVH

SLFN11

271

Q7Z7L1
IVGAVVKARDKYRHP

PDLIM3

301

Q53GG5
YNEGLVKRLHKVLRP

SRCAP

821

Q6ZRS2
DLIKRARLAKVHAYI

EHD3

296

Q9NZN3
KKHKRTPALIALRYQ

AKR1C1

246

Q04828
KKHKRTPALIALRYQ

AKR1C2

246

P52895
YHSRIPKKQRKRTIV

DNTTIP2

701

Q5QJE6
EKFHRRIYKGIPLQL

USP6NL

91

Q92738
AHVVALSLYRIRKPD

ZSWIM5

246

Q9P217
HAYIGLKDRKRPSEL

VWF

1326

P04275
HELRKRYNVTAIPKL

NXNL2

101

Q5VZ03
LSRVLYRPQLEKSKH

RHBG

196

Q9H310
RLKPRQHYLDSIKEL

SERPINA11

146

Q86U17
KRATHVPYRDSKLTR

KIF21A

316

Q7Z4S6
KELLLKPHSYGRFIR

SPDEF

256

O95238
SKHRLIPLGRKIYEF

TRPM3

876

Q9HCF6
VLQRLRKIYHSSIKP

SRL

56

Q86TD4
VSRHIIRKPRIYECK

ZBTB44

476

Q8NCP5
LATRRVHPALDTYIK

TEX264

146

Q9Y6I9
GLHEDLNRIRKKPYI

USP15

391

Q9Y4E8
KRKLRTDIHYPLTNL

USP50

281

Q70EL3
KELLKRTPRKHSDYA

PREX2

181

Q70Z35
AKRLVLTHFSQRYKP

ELAC1

306

Q9H777
AKIIRHPKYNSRTLD

PRSS2

91

P07478
DLAKKRVHPDYVITT

DCT

146

P40126
KRKYLHRPSRTAELK

ZCCHC10

61

Q8TBK6
PELVKRVRDLYHKRL

SYMPK

871

Q92797
VLVYTPSRKVHGKRL

ZC3H12D

161

A2A288
KVYAAKIIPHSRVAK

PLK2

106

Q9NYY3
RRAKHYKSPSELLEI

SMYD2

306

Q9NRG4
ERKRRRHTLYAKPAL

TCHH

881

Q07283
RVRTHDLKKIAPYVA

PC

581

P11498
HLLLYRIRKDVVPAD

VPS39

36

Q96JC1
VQPVKRELLRHRDYK

ZMAT2

41

Q96NC0
LHKRRKALTEPEARY

PLK1

141

P53350
RYHLRSKKDDINLLP

TPX2

341

Q9ULW0
LESTRRLHDEYKPLK

ZC4H2

91

Q9NQZ6
YYLLHKSIQEEKRRP

MYO3A

1511

Q8NEV4
KSRYRIRVEGKKHIL

MYBPC1

386

Q00872
TKPYKHRDDRLLQAL

PCSK1

731

P29120