Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	pyruvate dehydrogenase (acetyl-transferring) kinase activity	PDK1 PDK2	5.40e-05	5	47	2	GO:0004740
GeneOntologyMolecularFunction	pore-forming activity	MMD MMD2	2.41e-04	10	47	2	GO:0140911
GeneOntologyBiologicalProcess	regulation of acetyl-CoA biosynthetic process from pyruvate	PDK1 PDK2	3.04e-05	4	47	2	GO:0010510
GeneOntologyBiologicalProcess	regulation of acyl-CoA biosynthetic process	PDK1 PDK2	5.06e-05	5	47	2	GO:0050812
GeneOntologyCellularComponent	pyruvate dehydrogenase complex	PDK1 PDK2	1.37e-04	8	47	2	GO:0045254
GeneOntologyCellularComponent	Golgi membrane	ZDHHC2 MYMK MGAT5 MMD2 CHST4 SURF4 NLRP3 SLC35A5	1.84e-04	721	47	8	GO:0000139
GeneOntologyCellularComponent	alpha-ketoacid dehydrogenase complex	PDK1 PDK2	7.40e-04	18	47	2	GO:0045240
GeneOntologyCellularComponent	secretory granule membrane	HVCN1 SURF4 GP2 ITPR3 NCKAP1L	8.36e-04	329	47	5	GO:0030667
GeneOntologyCellularComponent	nuclear membrane	UGT2B15 INTS2 SURF4 NEMP2 ITPR3	1.09e-03	349	47	5	GO:0031965
Domain	Hy-lIII	MMD MMD2	6.20e-06	2	47	2	IPR005744
Domain	BCDHK_Adom3	PDK1 PDK2	6.17e-05	5	47	2	PF10436
Domain	His_kinase_dom	PDK1 PDK2	6.17e-05	5	47	2	IPR005467
Domain	HIS_KIN	PDK1 PDK2	6.17e-05	5	47	2	PS50109
Domain	-	PDK1 PDK2	6.17e-05	5	47	2	1.20.140.20
Domain	BCDHK/PDK_N	PDK1 PDK2	6.17e-05	5	47	2	IPR018955
Domain	RIH_assoc	RYR1 ITPR3	9.24e-05	6	47	2	PF08454
Domain	RIH_assoc-dom	RYR1 ITPR3	9.24e-05	6	47	2	IPR013662
Domain	RYDR_ITPR	RYR1 ITPR3	9.24e-05	6	47	2	PF01365
Domain	RIH_dom	RYR1 ITPR3	9.24e-05	6	47	2	IPR000699
Domain	Ins145_P3_rcpt	RYR1 ITPR3	9.24e-05	6	47	2	IPR014821
Domain	Ryanodine_recept-rel	RYR1 ITPR3	9.24e-05	6	47	2	IPR015925
Domain	Ins145_P3_rec	RYR1 ITPR3	9.24e-05	6	47	2	PF08709
Domain	-	RYR1 ITPR3	9.24e-05	6	47	2	1.25.10.30
Domain	MIR	RYR1 ITPR3	2.75e-04	10	47	2	PS50919
Domain	MIR	RYR1 ITPR3	2.75e-04	10	47	2	PF02815
Domain	MIR	RYR1 ITPR3	2.75e-04	10	47	2	SM00472
Domain	MIR_motif	RYR1 ITPR3	2.75e-04	10	47	2	IPR016093
Domain	AdipoR/HlyIII-related	MMD MMD2	3.36e-04	11	47	2	IPR004254
Domain	HlyIII	MMD MMD2	3.36e-04	11	47	2	PF03006
Domain	HATPase_c	PDK1 PDK2	9.24e-04	18	47	2	SM00387
Domain	HATPase_c	PDK1 PDK2	1.03e-03	19	47	2	PF02518
Domain	-	PDK1 PDK2	1.14e-03	20	47	2	3.30.565.10
Domain	HATPase_C	PDK1 PDK2	1.26e-03	21	47	2	IPR003594
Domain	DAPIN	NLRP14 NLRP3	1.39e-03	22	47	2	PS50824
Domain	DAPIN	NLRP14 NLRP3	1.39e-03	22	47	2	IPR004020
Domain	PYRIN	NLRP14 NLRP3	1.39e-03	22	47	2	SM01289
Domain	PYRIN	NLRP14 NLRP3	1.39e-03	22	47	2	PF02758
Domain	NACHT	NLRP14 NLRP3	1.52e-03	23	47	2	PS50837
Domain	NACHT_NTPase	NLRP14 NLRP3	1.52e-03	23	47	2	IPR007111
Domain	Ion_trans_dom	HVCN1 RYR1 ITPR3	2.95e-03	114	47	3	IPR005821
Domain	Ion_trans	HVCN1 RYR1 ITPR3	2.95e-03	114	47	3	PF00520
Domain	TBC	TBC1D12 TBC1D4	6.76e-03	49	47	2	SM00164
Domain	RabGAP-TBC	TBC1D12 TBC1D4	7.87e-03	53	47	2	PF00566
Domain	TBC_RABGAP	TBC1D12 TBC1D4	8.46e-03	55	47	2	PS50086
Domain	LRR_6	NLRP14 NLRP3	8.46e-03	55	47	2	PF13516
Domain	Rab-GTPase-TBC_dom	TBC1D12 TBC1D4	8.46e-03	55	47	2	IPR000195
Domain	BACK	KLHL10 BTBD7	1.00e-02	60	47	2	SM00875
Domain	BACK	KLHL10 BTBD7	1.03e-02	61	47	2	PF07707
Domain	BACK	KLHL10 BTBD7	1.03e-02	61	47	2	IPR011705
Domain	USP_CS	USP26 USP30	1.20e-02	66	47	2	IPR018200
Pubmed	Pyruvate dehydrogenase kinase 1 and 2 deficiency reduces high-fat diet-induced hypertrophic obesity and inhibits the differentiation of preadipocytes into mature adipocytes.	PDK1 PDK2	1.87e-06	2	48	2	34552205
Pubmed	MF-094, a potent and selective USP30 inhibitor, accelerates diabetic wound healing by inhibiting the NLRP3 inflammasome.	USP30 NLRP3	1.87e-06	2	48	2	34883112
Pubmed	Overexpression of pyruvate dehydrogenase kinase supports dichloroacetate as a candidate for cutaneous melanoma therapy.	PDK1 PDK2	1.87e-06	2	48	2	25976231
Pubmed	PDH activation during in vitro muscle contractions in PDH kinase 2 knockout mice: effect of PDH kinase 1 compensation.	PDK1 PDK2	1.87e-06	2	48	2	21411764
Pubmed	[Expression Level of Protein Kinase D in Oral Squamous Cell Carcinoma with Diverse Differentiation].	PDK1 PDK2	1.87e-06	2	48	2	33236596
Pubmed	Common allosteric mechanisms between ryanodine and inositol-1,4,5-trisphosphate receptors.	RYR1 ITPR3	1.87e-06	2	48	2	21150295
Pubmed	Characterization of the binding sites for the interactions between FKBP12 and intracellular calcium release channels.	RYR1 ITPR3	1.12e-05	4	48	2	22100703
Pubmed	Tissue-specific kinase expression and activity regulate flux through the pyruvate dehydrogenase complex.	PDK1 PDK2	1.12e-05	4	48	2	30482839
Pubmed	Differing roles of pyruvate dehydrogenase kinases during mouse oocyte maturation.	PDK1 PDK2	1.12e-05	4	48	2	25991547
Pubmed	Formation of functional heterodimers by isozymes 1 and 2 of pyruvate dehydrogenase kinase.	PDK1 PDK2	1.12e-05	4	48	2	12573248
Pubmed	Diversity of the pyruvate dehydrogenase kinase gene family in humans.	PDK1 PDK2	1.12e-05	4	48	2	7499431
Pubmed	Regulation of pyruvate dehydrogenase activity through phosphorylation at multiple sites.	PDK1 PDK2	1.86e-05	5	48	2	11485553
Pubmed	Interaction between the individual isoenzymes of pyruvate dehydrogenase kinase and the inner lipoyl-bearing domain of transacetylase component of pyruvate dehydrogenase complex.	PDK1 PDK2	1.86e-05	5	48	2	11978179
Pubmed	Site specificity of four pyruvate dehydrogenase kinase isoenzymes toward the three phosphorylation sites of human pyruvate dehydrogenase.	PDK1 PDK2	1.86e-05	5	48	2	11486000
Pubmed	Roles of I(f) and intracellular Ca2+ release in spontaneous activity of ventricular cardiomyocytes during murine embryonic development.	RYR1 ITPR3	2.79e-05	6	48	2	23463619
Pubmed	A calcium-induced calcium release mechanism supports luteinizing hormone-induced testosterone secretion in mouse Leydig cells.	RYR1 ITPR3	2.79e-05	6	48	2	20519450
Pubmed	Essential Roles of Intracellular Calcium Release Channels in Muscle, Brain, Metabolism, and Aging.	RYR1 ITPR3	2.79e-05	6	48	2	25966694
Pubmed	BCKDK regulates the TCA cycle through PDC in the absence of PDK family during embryonic development.	PDK1 PDK2	2.79e-05	6	48	2	33773101
Pubmed	PAQR10 and PAQR11 mediate Ras signaling in the Golgi apparatus.	MMD MMD2	2.79e-05	6	48	2	21968647
Pubmed	IP3Rs are sufficient for dendritic cell Ca2+ signaling in the absence of RyR1.	RYR1 ITPR3	2.79e-05	6	48	2	16844763
Pubmed	Pancreatic expression and mitochondrial localization of the progestin-adipoQ receptor PAQR10.	MMD MMD2	2.79e-05	6	48	2	18769639
Pubmed	Developmental expression of the calcium release channels during early neurogenesis of the mouse cerebral cortex.	RYR1 ITPR3	3.90e-05	7	48	2	11860456
Pubmed	Roles of IP3R and RyR Ca2+ channels in endoplasmic reticulum stress and beta-cell death.	RYR1 ITPR3	5.19e-05	8	48	2	19033399
Pubmed	Intracellular immune sensing promotes inflammation via gasdermin D-driven release of a lectin alarmin.	MGAT5 NLRP3	5.19e-05	8	48	2	33398185
Pubmed	PAQR proteins: a novel membrane receptor family defined by an ancient 7-transmembrane pass motif.	MMD MMD2	1.02e-04	11	48	2	16044242
Pubmed	NODs: intracellular proteins involved in inflammation and apoptosis.	NLRP14 NLRP3	1.22e-04	12	48	2	12766759
Pubmed	Recent advances in mechanisms regulating glucose oxidation at the level of the pyruvate dehydrogenase complex by PDKs.	PDK1 PDK2	1.22e-04	12	48	2	12676647
Pubmed	Hypoxia-induced proteasomal degradation of DBC1 by SIAH2 in breast cancer progression.	USP26 USP30	1.44e-04	13	48	2	35913115
Pubmed	The genetics of NOD-like receptors in Crohn's disease.	NLRP14 NLRP3	1.68e-04	14	48	2	20403135
Pubmed	NALPs: a novel protein family involved in inflammation.	NLRP14 NLRP3	1.68e-04	14	48	2	12563287
Pubmed	Functional Analysis of Mmd2 and Related PAQR Genes During Sex Determination in Mice.	MMD MMD2	1.94e-04	15	48	2	35306493
Pubmed	Voltage-dependent conformational changes of Kv1.3 channels activate cell proliferation.	DOCK7 TBC1D4 SURF4 RYR1	1.97e-04	208	48	4	33230847
Pubmed	Analysis of interaction partners for eukaryotic translation elongation factor 1A M-domain by functional proteomics.	KLHL10 EIF4G2	3.49e-04	20	48	2	21689717
Pubmed	Identification of Modifier Genes in a Mouse Model of Gaucher Disease.	MGAT5 ITPR3	4.23e-04	22	48	2	27568557
Pubmed	Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling.	PCDH15 DOCK7 TSPAN18 MMD2	4.93e-04	265	48	4	19240061
Pubmed	Identification of multipotent progenitors in the embryonic mouse kidney by a novel colony-forming assay.	PDK1 PDK2	1.20e-03	37	48	2	16319116
Pubmed	Maternal Transient Receptor Potential Vanilloid 6 (Trpv6) Is Involved In Offspring Bone Development.	RYR1 ITPR3	1.27e-03	38	48	2	30786075
Cytoband	9q34.2	MYMK SURF4	1.22e-04	16	47	2	9q34.2
Cytoband	Ensembl 112 genes in cytogenetic band chr11p15	OR52B4 NLRP14 CYP2R1 OR51M1 EIF4G2	2.76e-04	564	47	5	chr11p15
Cytoband	12q24.11	USP30 HVCN1	5.31e-04	33	47	2	12q24.11
Cytoband	11p15.4	OR52B4 NLRP14 OR51M1	1.15e-03	200	47	3	11p15.4
GeneFamily	Progestin and adipoQ receptor family	MMD MMD2	1.65e-04	11	32	2	930
GeneFamily	Pyrin domain containing\|Pyrin and HIN domain family	NLRP14 NLRP3	8.88e-04	25	32	2	994
GeneFamily	NLR family	NLRP14 NLRP3	8.88e-04	25	32	2	666
GeneFamily	Ubiquitin specific peptidases	USP26 USP30	4.40e-03	56	32	2	366
Disease	blood nickel measurement	ZDHHC2 ABCC1 TSPAN18 NLRP3	3.41e-05	120	45	4	EFO_0007583
Disease	word reading	PCDH15 DOCK7 NLRP3	1.36e-04	65	45	3	EFO_0005300
Disease	glucose tolerance test	HKDC1 TBC1D4	7.79e-04	27	45	2	EFO_0004307
Disease	non-alcoholic fatty liver disease (implicated_via_orthology)	UBR1 NLRP3	1.39e-03	36	45	2	DOID:0080208 (implicated_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
LAFFRVDHSMMLKYF	TBC1D12	621	O60347
FFYMHNEIFEEMLKR	USP26	881	Q9BXU7
MLDILEMFLNFHYLT	EP400	1926	Q96L91
QFSHAMDAMLFRLYL	HTR3E	426	A5X5Y0
MLMKFLTFCLEYEQH	CHML	296	P26374
MMEILRYTHQFLQKF	ITPR3	1221	Q14573
SHLYHMVFELFKNAM	PDK1	271	Q15118
HCLHMFDRMVIYFFI	MMD2	101	Q8IY49
DFNILYSMMKKHEEF	MGAT5	221	Q09328
AMVFHYMSITILVFF	HVCN1	136	Q96D96
FEKFYMLVCMLLAHQ	EFCAB9	81	A8MZ26
KHWIFIPFFFMYMVA	OR51M1	36	Q9H341
IFISYMLILHAVFHM	OR52B4	216	Q8NGK2
YMIHVNRNIMDFKLF	NEMP2	141	A6NFY4
QMFMFAGHYDLVFLH	GP2	446	P55259
FVFFYCDMLKIASMH	GPR119	181	Q8TDV5
FGEMLLLVAMYFHSN	INTS2	476	Q9H0H0
FCFHLRIFEKMFAMT	NCKAP1L	541	P55160
GMLLRFFVHFYDMEI	EIF4G2	846	P78344
EMNHYALFKCYMFLK	C17orf75	341	Q9HAS0
FHMCDRMVIYFFIAA	MMD	96	Q15546
YHMLFELFKNAMRAT	PDK2	246	Q15119
TAMLFHNMRRSYFKF	PCDH15	1206	Q96QU1
YMFILHNFEEMVKVS	KLHL10	161	Q6JEL2
FFELMVKSMVHHLYF	DOCK7	1011	Q96N67
MEMFLFFTALLQRFH	CYP2R1	456	Q6VVX0
MELYHIALFLEFNML	BTBD7	371	Q9P203
LEEHNLANYMFFLMY	RYR1	4981	P21817
LFYMDHKSAKMLLAF	FPGT	286	O14772
LMSFFFKAIHDLMMF	ABCC1	326	P33527
IHMTFQEFFAAMYYL	NLRP3	521	Q96P20
MFAVHLMAFYFSKLK	HKDC1	1	Q2TB90
HKNFEDFYSFMIMKT	SAMD9	876	Q5K651
MHDFLKYDFFQTMSV	SURF4	231	O15260
MNCNFMHIFKFVLDF	OR5T2	26	Q8NGG2
QMAILALFFHMYSHN	CHST4	16	Q8NCG5
AFILKFLDNMFHVLM	SLC35A5	321	Q9BS91
HELIFSSFFMEMEYK	UBR1	371	Q8IWV7
QAFEMLKFLMYDLGF	TBC1D4	1026	O60343
LSCMKYLMFVFNFFI	TSPAN18	6	Q96SJ8
EHVQFNEFLMMDIYK	USP30	341	Q70CQ3
QAKFHIMFLFFAAAM	ZDHHC2	206	Q9UIJ5
RIKNMIHMLYFDFWF	UGT2B15	211	P54855
RAFFYQSFLMRHMKI	ZNF114	311	Q8NC26
VKNDFAFMLHMIDQY	LRRC8C	366	Q8TDW0
HMEAMVYLFTLFFVA	MYMK	31	A6NI61
LHVQEFFAAMFYMLK	NLRP14	481	Q86W24