Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	regulation of Wnt signaling pathway involved in heart development	LRP6 ALPK2	2.96e-06	2	36	2	GO:0003307
GeneOntologyBiologicalProcess	negative regulation of Wnt signaling pathway involved in heart development	LRP6 ALPK2	2.96e-06	2	36	2	GO:0003308
GeneOntologyBiologicalProcess	Wnt signaling pathway involved in heart development	LRP6 ALPK2	1.77e-05	4	36	2	GO:0003306
GeneOntologyBiologicalProcess	cell surface receptor signaling pathway involved in heart development	LRP6 ALPK2	1.06e-04	9	36	2	GO:0061311
HumanPheno	Cerebellar medulloblastoma	APC KEAP1	2.77e-05	3	16	2	HP:0007129
Domain	UBA-like	NXF2 USP5	7.13e-03	64	37	2	IPR009060
Domain	USP_CS	USP5 USP32	7.56e-03	66	37	2	IPR018200
Pubmed	Unveiling the Roles of Low-Density Lipoprotein Receptor-Related Protein 6 in Intestinal Homeostasis, Regeneration and Oncogenesis.	APC LRP6	1.16e-06	2	38	2	34359960
Pubmed	PGC-1β promotes enterocyte lifespan and tumorigenesis in the intestine.	APC PPARGC1B	1.16e-06	2	38	2	25288742
Pubmed	siRNA screening identifies differences in the Fanconi anemia pathway in BALB/c-Trp53+/- with susceptibility versus C57BL/6-Trp53+/- mice with resistance to mammary tumors.	FANCB ERCC5 REV3L	3.07e-06	26	38	3	23435420
Pubmed	[Association of CDH1, FANCB and APC Gene Polymorphisms  with Lung Cancer Susceptibility in Chinese Population].	APC FANCB	3.48e-06	3	38	2	36172730
Pubmed	Nrf2 activation does not affect adenoma development in a mouse model of colorectal cancer.	APC KEAP1	3.48e-06	3	38	2	34526660
Pubmed	Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	PLEKHH1 OGDHL PARP14 XPO5	4.96e-06	103	38	4	10574462
Pubmed	Spatiotemporal regulation of liver development by the Wnt/β-catenin pathway.	APC CPS1	6.96e-06	4	38	2	29426940
Pubmed	Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.	APC LRP6 OGDHL FANCB LAPTM4A REV3L CPS1 ANO3 HEPH	8.12e-06	1293	38	9	15342556
Pubmed	Impaired plasma membrane localization of ubiquitin ligase complex underlies 3-M syndrome development.	PWP1 USP5 CHD1 KEAP1 WDR4 ATP6V0A2	1.53e-05	496	38	6	31343991
Pubmed	Mapping Wnt/beta-catenin signaling during mouse development and in colorectal tumors.	APC LRP6	1.74e-05	6	38	2	12626757
Pubmed	NF-E2-related factor 1 (Nrf1) serves as a novel regulator of hepatic lipid metabolism through regulation of the Lipin1 and PGC-1β genes.	PPARGC1B KEAP1	1.74e-05	6	38	2	22586274
Pubmed	Protein encoded by the Axin(Fu) allele effectively down-regulates Wnt signaling but exerts a dominant negative effect on c-Jun N-terminal kinase signaling.	APC MAP3K4	2.43e-05	7	38	2	18316368
Pubmed	DKK2 imparts tumor immunity evasion through β-catenin-independent suppression of cytotoxic immune-cell activation.	APC LRP6	2.43e-05	7	38	2	29431745
Pubmed	MAP3K1 functionally interacts with Axin1 in the canonical Wnt signalling pathway.	APC LRP6	4.16e-05	9	38	2	20128690
Pubmed	The regulation and deregulation of Wnt signaling by PARK genes in health and disease.	APC LRP6	5.20e-05	10	38	2	24115276
Pubmed	Genetic dissection of differential signaling threshold requirements for the Wnt/beta-catenin pathway in vivo.	APC CPS1	6.35e-05	11	38	2	20084116
Pubmed	Wnt signaling through inhibition of β-catenin degradation in an intact Axin1 complex.	APC LRP6	7.62e-05	12	38	2	22682247
Pubmed	CHD5 is required for neurogenesis and has a dual role in facilitating gene expression and polycomb gene repression.	APC CHD1	9.00e-05	13	38	2	23948251
Pubmed	USP32-regulated LAMTOR1 ubiquitination impacts mTORC1 activation and autophagy induction.	ATP6V0A2 USP32	1.21e-04	15	38	2	36476874
Pubmed	The COP9 signalosome mediates beta-catenin degradation by deneddylation and blocks adenomatous polyposis coli destruction via USP15.	APC LRP6	1.38e-04	16	38	2	19576224
Pubmed	Wilms tumor suppressor WTX negatively regulates WNT/beta-catenin signaling.	APC KEAP1	1.56e-04	17	38	2	17510365
Pubmed	SLFN11 promotes CDT1 degradation by CUL4 in response to replicative DNA damage, while its absence leads to synthetic lethality with ATR/CHK1 inhibitors.	APC CHD1 PARP14 XPO5	1.59e-04	250	38	4	33536335
Pubmed	Analysis of interaction partners for eukaryotic translation elongation factor 1A M-domain by functional proteomics.	APC GPSM1	2.18e-04	20	38	2	21689717
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	LAPTM4A KEAP1 ANKS3 HEPH DDHD1	2.65e-04	529	38	5	14621295
Pubmed	An atlas of combinatorial transcriptional regulation in mouse and man.	PWP1 NAP1L2 APC PPARGC1B TRIM22 ANKS3	3.50e-04	877	38	6	20211142
Pubmed	Protein interactome mining defines melatonin MT1 receptors as integral component of presynaptic protein complexes of neurons.	LAPTM4A USP5 SLC4A4 USP32	4.15e-04	322	38	4	26514267
Pubmed	Genetic variation in immune regulation and DNA repair pathways and stomach cancer in China.	ERCC5 REV3L	4.32e-04	28	38	2	19661089
Pubmed	Stabilization of beta-catenin affects mouse embryonic liver growth and hepatoblast fate.	APC CPS1	4.63e-04	29	38	2	18038450
Pubmed	The G4 resolvase Dhx36 modulates cardiomyocyte differentiation and ventricular conduction system development.	PLEKHH1 PPARGC1B	4.96e-04	30	38	2	39366945
Pubmed	A Large-scale genetic association study of esophageal adenocarcinoma risk.	APC PPARGC1B ERCC5 REV3L	5.74e-04	351	38	4	20453000
Pubmed	Lrp4 and Wise interplay controls the formation and patterning of mammary and other skin appendage placodes by modulating Wnt signaling.	APC LRP6	6.38e-04	34	38	2	23293290
Pubmed	SLX4IP acts with SLX4 and XPF-ERCC1 to promote interstrand crosslink repair.	KEAP1 HEPH	6.38e-04	34	38	2	31495888
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	PWP1 BEND3 USP5 CHD1 XPO5	6.91e-04	653	38	5	22586326
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	PLEKHH1 BEND3 XPO5 MAP3K4	9.96e-04	407	38	4	12693553
GeneFamily	Ubiquitin specific peptidases	USP5 USP32	2.70e-03	56	25	2	366
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	PLEKHH1 FGD5 IPCEF1	2.79e-03	206	25	3	682
Disease	renal tubular acidosis (implicated_via_orthology)	SLC4A4 ATP6V0A2	4.26e-05	8	37	2	DOID:14219 (implicated_via_orthology)
Disease	gallbladder cancer (is_implicated_in)	APC KEAP1	1.18e-04	13	37	2	DOID:3121 (is_implicated_in)
Disease	anemia (implicated_via_orthology)	APC SLC4A4	1.59e-04	15	37	2	DOID:2355 (implicated_via_orthology)
Disease	Lipidemias	APC PPARGC1B	2.06e-04	17	37	2	C1706412
Disease	Hyperlipidemia	APC PPARGC1B	2.06e-04	17	37	2	C0020473
Disease	Bilateral Wilms Tumor	XPO5 MAP3K4	6.08e-04	29	37	2	C2930471
Disease	prostate cancer (implicated_via_orthology)	APC CHD1	7.88e-04	33	37	2	DOID:10283 (implicated_via_orthology)
Disease	Nephroblastoma	XPO5 MAP3K4	9.38e-04	36	37	2	C0027708
Disease	nitric oxide exhalation measurement	SLC4A4 ANO3	1.05e-03	38	37	2	EFO_0005536
Disease	cystatin C measurement	USP5 CPS1 XPO5 IPCEF1	1.57e-03	402	37	4	EFO_0004617
Disease	Adenocarcinoma of lung (disorder)	APC KEAP1 SLC4A4	2.19e-03	206	37	3	C0152013

Protein segments in the cluster

Peptide	Gene	Start	Entry
SEDSDSDYELCPEIT	ALPK2	301	Q86TB3
EKSSCDETESDYEPK	CHD1	171	O14646
DKSAFPDLEESDCYT	ANO3	266	Q9BYT9
PTEEECEYKSDSEDC	NAP1L2	161	Q9ULW6
DDCYDSSSLPDDISV	BEND3	496	Q5T5X7
SYTVCVSEPDKDDDF	HSFY1	61	Q96LI6
PSSDEECFFDLLTKF	GPSM1	491	Q86YR5
DFPYKDDLLALDSSC	LAPTM4A	146	Q15012
DDSDAYPAFTKDFEV	OGDHL	791	Q9ULD0
RSIPKCSESETDEDY	FGD5	51	Q6ZNL6
CSDKSDELDCYPTEE	LRP6	1351	O75581
DYSEDFLCDCSEKAI	LCA5L	66	O95447
EEEAECYFHSRPKSS	PNPO	151	Q9NVS9
LSEEECTQEPSKSDY	FANCB	191	Q8NB91
PYTSEDECIKDFDEK	PARP14	1456	Q460N5
STDFDECDKLYFEEL	CPS1	1021	P31327
TKDEECYSESEQEDP	IPCEF1	146	Q8WWN9
PEKYEDLSSSDESCP	ANKS3	236	Q6ZW76
TFLDSVECYDPDTDT	KEAP1	576	Q14145
DPCLSDENYDFSSAE	DDHD1	81	Q8NEL9
DSAPSSLCKYFEDSR	NXF2	431	Q9GZY0
CKSPESDLEDFSDET	MAP3K4	61	Q9Y6R4
ATYCSDPASVDKEDE	HEPH	246	Q9BQS7
PYESKFDSSLLSSDD	ERCC5	551	P28715
EEEDLASCKSPEYDT	PPARGC1B	776	Q86YN6
ASCKSPEYDTVFEDS	PPARGC1B	781	Q86YN6
PSIESYSEDDESKFC	APC	981	P25054
DKSVALYDCRSPDES	PWP1	321	Q13610
PVSSCESSIFDYEED	REV3L	651	O60673
SPSCEYSRFDFDSDE	XPO5	416	Q9HAV4
DACSLDSDYSEPEHK	PLEKHH1	546	Q9ULM0
SLDSDNDDSDCPYSE	SLC4A4	1026	Q9Y6R1
DDDSLFIYDCSAAEK	WDR4	31	P57081
EKAPETDDSFSDVDC	PMS2CL	151	Q68D20
CYRKAFELDDTDAES	TTC37	516	Q6PGP7
CEYNAFEDSSSSDPK	TRIM22	416	Q8IYM9
HKDECAFSFDTPESE	USP5	26	P45974
CKELHPDEIDTDSAY	USP32	1546	Q8NFA0
EFPSLESDSLLDYSC	ATP6V0A2	151	Q9Y487
DFSYCSEPSELDETV	KIAA1958	121	Q8N8K9