Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	AAA	VPS4B WRNIP1 BCS1L CHTF18	2.07e-04	52	105	4	PF00004
Domain	ATPase_AAA_core	VPS4B WRNIP1 BCS1L CHTF18	2.40e-04	54	105	4	IPR003959
Domain	ATPase_AAA_CS	VPS4B WRNIP1 BCS1L	5.67e-04	29	105	3	IPR003960
Domain	AAA	VPS4B WRNIP1 BCS1L	9.10e-04	34	105	3	PS00674
Domain	Isoprenoid_synthase_dom	PDSS1 WRNIP1	1.10e-03	9	105	2	IPR008949
Domain	AAA+_ATPase	VPS4B WRNIP1 BCS1L CHTF18 HELZ2	1.32e-03	144	105	5	IPR003593
Domain	AAA	VPS4B WRNIP1 BCS1L CHTF18 HELZ2	1.32e-03	144	105	5	SM00382
Domain	WD40_repeat_CS	WDFY4 SCAP TLE3 CORO6 TAF5	2.34e-03	164	105	5	IPR019775
Domain	SSD	SCAP DISP3	2.35e-03	13	105	2	IPR000731
Domain	SSD	SCAP DISP3	2.35e-03	13	105	2	PS50156
Domain	-	ESPN CDKN2A ANKZF1 ASB18 NFKBIB MYO16	2.78e-03	248	105	6	1.25.40.20
Domain	ANK	ESPN CDKN2A ANKZF1 ASB18 NFKBIB MYO16	2.95e-03	251	105	6	SM00248
Domain	ANK_REPEAT	ESPN CDKN2A ANKZF1 ASB18 NFKBIB MYO16	3.07e-03	253	105	6	PS50088
Domain	Ankyrin_rpt-contain_dom	ESPN CDKN2A ANKZF1 ASB18 NFKBIB MYO16	3.13e-03	254	105	6	IPR020683
Domain	ANK_REP_REGION	ESPN CDKN2A ANKZF1 ASB18 NFKBIB MYO16	3.13e-03	254	105	6	PS50297
Domain	WD40	WDFY4 SCAP WDR6 TLE3 CORO6 TAF5	3.44e-03	259	105	6	PF00400
Domain	Ankyrin_rpt	ESPN CDKN2A ANKZF1 ASB18 NFKBIB MYO16	3.64e-03	262	105	6	IPR002110
Domain	WD40	WDFY4 SCAP WDR6 TLE3 CORO6 TAF5	4.07e-03	268	105	6	SM00320
Domain	Tumour_necrosis_fac-like_dom	EMILIN1 HEY1 TNFSF15	4.26e-03	58	105	3	IPR008983
Domain	WD40_repeat	WDFY4 SCAP WDR6 TLE3 CORO6 TAF5	4.37e-03	272	105	6	IPR001680
Domain	EGF_extracell	RELN JAG2 HHIP	4.68e-03	60	105	3	IPR013111
Domain	EGF_2	RELN JAG2 HHIP	4.68e-03	60	105	3	PF07974
Domain	WD_REPEATS_1	WDFY4 SCAP WDR6 TLE3 CORO6 TAF5	4.85e-03	278	105	6	PS00678
Domain	WD_REPEATS_2	WDFY4 SCAP WDR6 TLE3 CORO6 TAF5	4.94e-03	279	105	6	PS50082
Domain	WD_REPEATS_REGION	WDFY4 SCAP WDR6 TLE3 CORO6 TAF5	4.94e-03	279	105	6	PS50294
Pathway	REACTOME_SIGNALING_BY_NOTCH1	MAML1 JAG2 HEY1 TLE3 HDAC10	3.70e-05	74	72	5	M616
Pathway	REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION	MAML1 HEY1 TLE3 HDAC10	1.03e-04	48	72	4	M611
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	TBC1D9B POLG MAML1 SFI1 WASHC2A JAG2 AATK SCAP RPAP1 SEC16A HELZ2 KAZALD1 TTC5 CHPF TRAPPC9 CEP170B ELL	9.54e-08	1105	112	17	35748872
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	ERCC5 WRNIP1 PI4K2A ADARB1 TERF2IP PHC3 RBM25 RPAP1 CHTF18 TLE3 SEC16A HELZ2	7.85e-06	774	112	12	15302935
Pubmed	The G protein α subunit variant XLαs promotes inositol 1,4,5-trisphosphate signaling and mediates the renal actions of parathyroid hormone in vivo.	PTH GNAS	1.03e-05	2	112	2	26307011
Pubmed	Enpp1 inhibits ectopic joint calcification and maintains articular chondrocytes by repressing hedgehog signaling.	ENPP1 HHIP GNAS	1.77e-05	16	112	3	30111653
Pubmed	RECQL4 and p53 potentiate the activity of polymerase γ and maintain the integrity of the human mitochondrial genome.	POLG RECQL4	3.08e-05	3	112	2	24067899
Pubmed	The LMTK1-TBC1D9B-Rab11A Cascade Regulates Dendritic Spine Formation via Endosome Trafficking.	TBC1D9B AATK	3.08e-05	3	112	2	31628178
Pubmed	Heterotrimeric G proteins in the control of parathyroid hormone actions.	PTH GNAS	3.08e-05	3	112	2	28363951
Pubmed	Identification and functional characterization of transcriptional activators in human cells.	RC3H2 ADNP2 MAML1 PHC3 GLA TLE3 SEC16A MYO15A	4.63e-05	398	112	8	35016035
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	TRAF3IP2 RC3H2 TCF12 ENPP1 ANKZF1 RPAP1 WDR6 CHTF18 RECQL4 TASOR	4.97e-05	650	112	10	38777146
Pubmed	Analysis of the multi-copy gene family FAM90A as a copy number variant in different ethnic backgrounds.	FAM90A17 FAM90A8 FAM90A16	5.49e-05	23	112	3	18602769
Pubmed	Whirlin complexes with p55 at the stereocilia tip during hair cell development.	GNAS MYO15A	6.14e-05	4	112	2	16829577
Pubmed	Gsα deficiency in the dorsomedial hypothalamus underlies obesity associated with Gsα mutations.	CHAT GNAS	6.14e-05	4	112	2	27991864
Pubmed	[Abnormal expression of c-myc, p53, p16 protein and GNAS1 gene mutation in fibrous dysplasia].	CDKN2A GNAS	6.14e-05	4	112	2	19575869
Pubmed	Evidence for a cell-specific action of Reelin in the spinal cord.	RELN CHAT	6.14e-05	4	112	2	11900467
Pubmed	Transcriptional maps of 10 human chromosomes at 5-nucleotide resolution.	RELN CLIP2 DGLUCY SIGLEC1	6.30e-05	66	112	4	15790807
Pubmed	NOTCH1 nuclear interactome reveals key regulators of its transcriptional activity and oncogenic function.	TCF12 MAML1 PRPF6 WDR6 TRAPPC9	6.34e-05	129	112	5	23022380
Pubmed	Characterization and evolution of the novel gene family FAM90A in primates originated by multiple duplication and rearrangement events.	FAM90A17 FAM90A8 FAM90A16	7.10e-05	25	112	3	17684299
Pubmed	Targeting of the hair cell proteins cadherin 23, harmonin, myosin XVa, espin, and prestin in an epithelial cell model.	ESPN MYO15A	1.02e-04	5	112	2	20505086
Pubmed	Human Immunodeficiency Virus Type 1 Vpr Mediates Degradation of APC1, a Scaffolding Component of the Anaphase-Promoting Complex/Cyclosome.	VPS4B WRNIP1 WASHC2A GNAS TASOR MRPL9	1.38e-04	242	112	6	34011540
Pubmed	The COMPASS Family Protein ASH2L Mediates Corticogenesis via Transcriptional Regulation of Wnt Signaling.	RELN ADNP2 AATK	1.51e-04	32	112	3	31315048
Pubmed	Chat, a Cas/HEF1-associated adaptor protein that integrates multiple signaling pathways.	CHAT NEDD9	1.53e-04	6	112	2	10692442
Pubmed	The Jagged2 gene maps to chromosome 12 and is a candidate for the lgl and sm mutations.	JAG2 PTPRN2	1.53e-04	6	112	2	9341252
Pubmed	Genetic polymorphisms in 85 DNA repair genes and bladder cancer risk.	CDKN2A ERCC5 POLG RECQL4	1.61e-04	84	112	4	19237606
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	TBC1D9B CLIP2 WDFY4 SCAP HELZ2 DISP3 TASOR TRAPPC9	2.02e-04	493	112	8	15368895
Pubmed	Cochlear developmental defect and background-dependent hearing thresholds in the Jackson circler (jc) mutant mouse.	ESPN MYO15A	2.14e-04	7	112	2	16962269
Pubmed	SEL-10 is an inhibitor of notch signaling that targets notch for ubiquitin-mediated protein degradation.	MAML1 HEY1	2.14e-04	7	112	2	11585921
Pubmed	Pallial origin of basal forebrain cholinergic neurons in the nucleus basalis of Meynert and horizontal limb of the diagonal band nucleus.	RELN CHAT	2.14e-04	7	112	2	21865321
Pubmed	Analysis of hedgehog interacting protein in the brain and its expression in nitric oxide synthase-positive cells.	CHAT HHIP	2.14e-04	7	112	2	16272887
Pubmed	[Studies on the genetics and pathology of the development of 8 labyrinth mutants (deaf-waltzer-shaker mutants) in the mouse (Mus musculus)].	ESPN MYO15A	2.14e-04	7	112	2	13853422
Pubmed	Stabilization of the methyl-CpG binding protein ZBTB38 by the deubiquitinase USP9X limits the occurrence and toxicity of oxidative stress in human cells.	CDKN2A WRNIP1 CHTF18 SEC16A	2.59e-04	95	112	4	29490077
Pubmed	Regulation of epidermal differentiation through KDF1-mediated deubiquitination of IKKα.	WRNIP1 PRPF6 RBM25 WDR6 SEC16A	3.17e-04	182	112	5	32239614
Pubmed	Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1.	MAML1 GINS1 SCAP	3.17e-04	41	112	3	8724849
Pubmed	Genome-wide association study identifies five loci associated with lung function.	THSD4 HHIP	3.65e-04	9	112	2	20010834
Pubmed	Dermal TRPV1 innervations engage a macrophage- and fibroblast-containing pathway to activate hair growth in mice.	SCN10A GNAS	3.65e-04	9	112	2	38851191
Pubmed	Concordance of two multiple analytical approaches demonstrate that interaction between BMI and ADIPOQ haplotypes is a determinant of LDL cholesterol in a general French population.	ENPP1 SCAP	4.55e-04	10	112	2	20186155
Pubmed	Bmi-1 over-expression in neural stem/progenitor cells increases proliferation and neurogenesis in culture but has little effect on these functions in vivo.	CDKN2A RELN	4.55e-04	10	112	2	19389366
Pubmed	Hundreds of variants clustered in genomic loci and biological pathways affect human height.	JMJD4 HHIP SCMH1 TLE3 TASOR	4.66e-04	198	112	5	20881960
Pubmed	High-throughput analyses of hnRNP H1 dissects its multi-functional aspect.	CDKN2A WRNIP1 ADARB1 ASB18 RBM25 WDR6 SH3PXD2A SAMD11 CHTF18 KAZALD1 ELL	4.67e-04	1021	112	11	26760575
Pubmed	Erk and MAPK signaling is essential for intestinal development through Wnt pathway modulation.	CHAT JAG2 HHIP	4.75e-04	47	112	3	32747435
Pubmed	Mapping the mammalian ribosome quality control complex interactome using proximity labeling approaches.	CDKN2A VPS4B WASHC2A RBM25 TLE3	5.10e-04	202	112	5	29540532
Pubmed	The G protein α subunit Gαs is a tumor suppressor in Sonic hedgehog-driven medulloblastoma.	HHIP GNAS	5.55e-04	11	112	2	25150496
Pubmed	Celsr3 and Fzd3 Organize a Pioneer Neuron Scaffold to Steer Growing Thalamocortical Axons.	RELN CHAT	5.55e-04	11	112	2	27170656
Pubmed	Interactomes of Glycogen Synthase Kinase-3 Isoforms.	RC3H2 WASHC2A MAST4 SEC16A CEP170B	5.95e-04	209	112	5	36779422
Pubmed	Protein interactome mining defines melatonin MT1 receptors as integral component of presynaptic protein complexes of neurons.	CLIP2 BTBD1 SCN10A DISP3 GNAS HDAC10	6.32e-04	322	112	6	26514267
Pubmed	Genome-wide association study of lung function phenotypes in a founder population.	THSD4 TLE3	6.64e-04	12	112	2	23932459
Pubmed	Gαs regulates asymmetric cell division of cortical progenitors by controlling Numb mediated Notch signaling suppression.	HEY1 GNAS	6.64e-04	12	112	2	25916881
Pubmed	Human transcription factor protein interaction networks.	CDKN2A TCF12 MAML1 WASHC2A PHC3 RBM25 NKX2-4 SAMD11 TLE3 NFKBIB SEC16A TAF5 TRAPPC9	7.02e-04	1429	112	13	35140242
Pubmed	The TRIM9/TRIM67 neuronal interactome reveals novel activators of morphogenesis.	CLIP2 HOOK3 TTC5 CEP170B MYO16	7.20e-04	218	112	5	33378226
Pubmed	Comprehensive Interactome Mapping of the DNA Repair Scaffold SLX4 Using Proximity Labeling and Affinity Purification.	AFF3 MAML1 PRPF6 TERF2IP ELL	7.81e-04	222	112	5	37071664
Pubmed	Cyclin-dependent kinase 5/p35 contributes synergistically with Reelin/Dab1 to the positioning of facial branchiomotor and inferior olive neurons in the developing mouse hindbrain.	RELN CHAT	7.83e-04	13	112	2	12019323
Pubmed	Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.	CLIP2 AATK SCAP SEC16A HELZ2	8.29e-04	225	112	5	12168954
Pubmed	Comprehensive analysis of DNA repair gene variants and risk of meningioma.	ERCC5 POLG RECQL4	8.38e-04	57	112	3	18270339
Pubmed	MLL-AF9 and MLL-ENL alter the dynamic association of transcriptional regulators with genes critical for leukemia.	AFF3 ELL	9.12e-04	14	112	2	20854876
Pubmed	Activation of Hedgehog signaling by loss of GNAS causes heterotopic ossification.	HHIP GNAS	9.12e-04	14	112	2	24076664
Pubmed	Impaired embryonic haematopoiesis yet normal arterial development in the absence of the Notch ligand Jagged1.	JAG2 HEY1	9.12e-04	14	112	2	18528438
Pubmed	Construction and characterization of human brain cDNA libraries suitable for analysis of cDNA clones encoding relatively large proteins.	CLIP2 CEP170B	9.12e-04	14	112	2	9179496
Pubmed	Class III myosins shape the auditory hair bundles by limiting microvilli and stereocilia growth.	ESPN MYO15A	9.12e-04	14	112	2	26754646
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	ESPN POLG AFF3 ADARB1 TERF2IP ITPKB JAG2 PTPRN2 SH3PXD2A TLE3 GNAS TRAPPC9 CEP170B	1.02e-03	1489	112	13	28611215
Pubmed	Expression of Notch pathway genes in the embryonic mouse metanephros suggests a role in proximal tubule development.	JAG2 HEY1	1.05e-03	15	112	2	12971992
Pubmed	MCM10 mediates RECQ4 association with MCM2-7 helicase complex during DNA replication.	GINS1 RECQL4	1.05e-03	15	112	2	19696745
Pubmed	Premature myogenic differentiation and depletion of progenitor cells cause severe muscle hypotrophy in Delta1 mutants.	JAG2 HEY1	1.05e-03	15	112	2	17194759
Pubmed	Microbiota modulate sympathetic neurons via a gut-brain circuit.	CHAT SCN10A	1.05e-03	15	112	2	32641826
Pubmed	Developmental restriction of Mash-2 expression in trophoblast correlates with potential activation of the notch-2 pathway.	JAG2 TLE3	1.05e-03	15	112	2	9291577
Pubmed	Cas adaptor proteins organize the retinal ganglion cell layer downstream of integrin signaling.	CHAT NEDD9	1.05e-03	15	112	2	24559672
Pubmed	Embryonic and postnatal development of mouse olfactory tubercle.	RELN CHAT	1.20e-03	16	112	2	31200100
Pubmed	An essential role for Notch in neural crest during cardiovascular development and smooth muscle differentiation.	JAG2 HEY1	1.20e-03	16	112	2	17273555
Pubmed	Deficiency in the secreted protein Semaphorin3d causes abnormal parathyroid development in mice.	CDKN2A PTH	1.20e-03	16	112	2	30979723
Pubmed	Mind bomb1 is a ubiquitin ligase essential for mouse embryonic development and Notch signaling.	MAML1 HEY1	1.20e-03	16	112	2	16061358
Pubmed	The core of the polycomb repressive complex is compositionally and functionally conserved in flies and humans.	PHC3 SCMH1	1.20e-03	16	112	2	12167701
Pubmed	Mastermind-like 1 (MamL1) and mastermind-like 3 (MamL3) are essential for Notch signaling in vivo.	MAML1 HEY1	1.20e-03	16	112	2	22069191
Pubmed	Loss of BAF (mSWI/SNF) Complexes Causes Global Transcriptional and Chromatin State Changes in Forebrain Development.	CDKN2A RELN TFAP2E	1.23e-03	65	112	3	26655900
Pubmed	The role of Pax2 in mouse inner ear development.	JAG2 MYO15A	1.35e-03	17	112	2	15242798
Pubmed	Gamma-secretase activation of notch signaling regulates the balance of proximal and distal fates in progenitor cells of the developing lung.	JAG2 HEY1	1.35e-03	17	112	2	18694942
Pubmed	Gene expression during sex determination reveals a robust female genetic program at the onset of ovarian development.	TCF12 NEDD9	1.35e-03	17	112	2	16214126
Pubmed	A wide diversity of cortical GABAergic interneurons derives from the embryonic preoptic area.	RELN CHAT	1.35e-03	17	112	2	22090484
Pubmed	Different roles of Runx2 during early neural crest-derived bone and tooth development.	ENPP1 KAZALD1	1.35e-03	17	112	2	16813524
Pubmed	Segmental expression of Notch and Hairy genes in nephrogenesis.	JAG2 HEY1	1.35e-03	17	112	2	15821257
Pubmed	Proteome-wide Identification of HtrA2/Omi Substrates.	HTRA2 VPS4B	1.35e-03	17	112	2	17266347
Pubmed	Reelin regulates cadherin function via Dab1/Rap1 to control neuronal migration and lamination in the neocortex.	RELN TERF2IP	1.35e-03	17	112	2	21315259
Pubmed	The DNA sequence and comparative analysis of human chromosome 20.	AP5S1 PRPF6 GINS1 NKX2-4 HELZ2 SIGLEC1 GNAS	1.46e-03	517	112	7	11780052
Pubmed	Lunatic fringe null female mice are infertile due to defects in meiotic maturation.	JAG2 HEY1	1.52e-03	18	112	2	15659488
Pubmed	Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells.	CDKN2A RELN	1.52e-03	18	112	2	12714971
Pubmed	Developmental coronary maturation is disturbed by aberrant cardiac vascular endothelial growth factor expression and Notch signalling.	JAG2 HEY1	1.52e-03	18	112	2	18093989
Pubmed	RBPjkappa-dependent Notch function regulates Gata2 and is essential for the formation of intra-embryonic hematopoietic cells.	JAG2 HEY1	1.52e-03	18	112	2	15689374
Pubmed	Altered feto-placental vascularization, feto-placental malperfusion and fetal growth restriction in mice with Egfl7 loss of function.	EMILIN1 HEY1	1.70e-03	19	112	2	28526753
Pubmed	Primary cilia maintain corneal epithelial homeostasis by regulation of the Notch signaling pathway.	MAML1 HEY1	1.70e-03	19	112	2	27122169
Pubmed	The polycomb proteins EZH1 and EZH2 co-regulate chromatin accessibility and nephron progenitor cell lifespan in mice.	CDKN2A HEY1	1.70e-03	19	112	2	32554463
Pubmed	Transcriptional regulation of cortical neuron migration by POU domain factors.	RELN TLE3	1.88e-03	20	112	2	11859196
Pubmed	Jagged1 is a competitive inhibitor of Notch signaling in the embryonic pancreas.	JAG2 HEY1	1.88e-03	20	112	2	19501159
Pubmed	Evolution of Cortical Neurogenesis in Amniotes Controlled by Robo Signaling Levels.	RELN JAG2	1.88e-03	20	112	2	29961574
Pubmed	The protein interaction landscape of the human CMGC kinase group.	CDKN2A ERCC5 AFF3 PRPF6 RBM25 WDR6 TLE3 FAM222B	1.88e-03	695	112	8	23602568
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	CDKN2A ITPKB MAST4 SH3PXD2A SAMD11 SEC16A GNAS TRAPPC9 CEP170B	1.90e-03	861	112	9	36931259
Pubmed	A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning.	TCF12 WRNIP1 MAML1 PHETA2 ANKZF1 WASHC2A RPAP1 NFKBIB SEC16A GNAS	1.95e-03	1038	112	10	26673895
Pubmed	Placental PPARγ regulates spatiotemporally diverse genes and a unique metabolic network.	SGPP2 CHST13 FAM90A17 FAM90A8	1.99e-03	164	112	4	22967998
Pubmed	An obligatory role of mind bomb-1 in notch signaling of mammalian development.	JAG2 HEY1	2.07e-03	21	112	2	18043734
Pubmed	Neurovascular EGFL7 regulates adult neurogenesis in the subventricular zone and thereby affects olfactory perception.	CHAT JAG2	2.07e-03	21	112	2	28656980
Pubmed	The N-Myc-DLL3 cascade is suppressed by the ubiquitin ligase Huwe1 to inhibit proliferation and promote neurogenesis in the developing brain.	RELN JAG2	2.07e-03	21	112	2	19686682
Pubmed	Transcriptome-based systematic identification of extracellular matrix proteins.	THSD4 EMILIN1 KAZALD1	2.15e-03	79	112	3	18757743
Pubmed	An atlas of combinatorial transcriptional regulation in mouse and man.	TCF12 TFAP2E MAML1 ANKZF1 ZSCAN1 SCMH1 HDAC10 TAF5 ELL	2.16e-03	877	112	9	20211142
Pubmed	The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells.	TCF12 WASHC2A PHC3 SEC16A MRPL9	2.24e-03	282	112	5	23667531
GeneFamily	AAA ATPases	VPS4B WRNIP1 BCS1L CHTF18	5.23e-05	53	70	4	413
GeneFamily	AF4/FMR2 family\|Super elongation complex	AFF3 ELL	5.23e-04	9	70	2	1280
GeneFamily	WD repeat domain containing	WDFY4 SCAP WDR6 TLE3 CORO6 TAF5	5.28e-04	262	70	6	362
GeneFamily	Ankyrin repeat domain containing	ESPN ANKZF1 ASB18 NFKBIB MYO16	2.46e-03	242	70	5	403
Coexpression	GSE17721_CTRL_VS_GARDIQUIMOD_4H_BMDC_UP	BTBD1 PHETA2 WASHC2A EMILIN1 GINS1 DGLUCY SEC16A	1.97e-05	200	108	7	M3780
Coexpression	GSE2197_CPG_DNA_VS_UNTREATED_IN_DC_DN	ERCC5 BTBD1 AATK RPAP1 SCMH1 MYO15A TTC5	1.97e-05	200	108	7	M4398
Coexpression	HOELZEL_NF1_TARGETS_UP	THSD4 TRAF3IP2 RELN HHIP HEY1 GNAS	2.66e-05	141	108	6	M2142
ToppCell	droplet-Pancreas-Endocrine-21m\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EMILIN1 PTPRN2 WDR6 SH3PXD2A SEC16A CHPF CEP170B	5.11e-07	194	109	7	3a3ecedcdc7691cf21775818b598208fcb980c29
ToppCell	droplet-Pancreas-Endocrine-21m-Epithelial\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EMILIN1 PTPRN2 WDR6 SH3PXD2A SEC16A CHPF CEP170B	5.11e-07	194	109	7	0b023de48ed8a550d169bbe954881eb04bf4f981
ToppCell	normal_Lung-T/NK_cells-Exhausted_Tfh\|T/NK_cells / Location, Cell class and cell subclass	SGPP2 JMJD4 PHETA2 MAST4 KCNC3 CHPF	4.47e-06	174	109	6	e324320b52c904496e26fcecfa179b3431729ec0
ToppCell	facs-Pancreas-Exocrine-3m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CHAT ITPKB JAG2 MAST4 PTPRN2 SH3PXD2A	5.09e-06	178	109	6	fcbbcc44271515de1969b4732b6441c012693d5f
ToppCell	Basal\|World / shred by cell class for mouse tongue	AFF3 ADARB1 JAG2 NEDD9 SCMH1 WDR6	5.97e-06	183	109	6	c6729a207526ff4aa48176207b9353176f631fea
ToppCell	facs-Pancreas-Endocrine-24m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RELN EMILIN1 PTPRN2 SH3PXD2A SEC16A CHPF	6.96e-06	188	109	6	a91443aa8fa8fa87f7501c59219daa0305bd0bbf
ToppCell	droplet-Pancreas-Endocrine-21m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EMILIN1 PTPRN2 SH3PXD2A SEC16A CHPF CEP170B	8.09e-06	193	109	6	471e65f02937bc18d7c5facdacdf1df58cf0f839
ToppCell	droplet-Pancreas-Endocrine-21m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EMILIN1 PTPRN2 SH3PXD2A SEC16A CHPF CEP170B	8.09e-06	193	109	6	fe451b3295d77b2bd1ac25cf29310c85835a45fe
ToppCell	proximal-Hematologic-Interstitial_Macrophage\|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	RC3H2 PI4K2A CHST13 TLE3 RECQL4 SIGLEC1	8.83e-06	196	109	6	b6a858c43fef42cd724d56c8283e954bcb546106
ToppCell	proximal-3-Hematologic-Interstitial_Macrophage\|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	RC3H2 PI4K2A CHST13 TLE3 RECQL4 SIGLEC1	8.83e-06	196	109	6	d8c9cb86233470c3044865ad05ea202e294d80bf
ToppCell	proximal-Hematologic-Interstitial_Macrophage-3\|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	RC3H2 PI4K2A CHST13 TLE3 RECQL4 SIGLEC1	8.83e-06	196	109	6	9d4d8ffe9d30de7d1dc33d261bc2aaf4189ad86c
Drug	Sulpiride [15676-16-1]; Down 200; 11.8uM; HL60; HG-U133A	HTRA2 ADNP2 PRPF6 SFI1 DGLUCY RBM25 FAM222B SCN10A TASOR	3.74e-07	196	107	9	1967_DN
Drug	Proparacaine hydrochloride [5875-06-9]; Down 200; 12uM; PC3; HT_HG-U133A	TBC1D9B PI4K2A JMJD4 PRPF6 ANKZF1 ITPKB JAG2 NEDD9 TLE3	4.08e-07	198	107	9	6332_DN
Drug	Chlorpheniramine maleate [113-92-8]; Down 200; 10.2uM; HL60; HG-U133A	TRAF3IP2 SFI1 ADARB1 AATK RPAP1 TLE3 SCN10A TRAPPC9	3.96e-06	195	107	8	1371_DN
Drug	Coralyne chloride hydrate [38989-38-7]; Up 200; 9.6uM; HL60; HT_HG-U133A	CDKN2A AP5S1 CLIP2 SFI1 TLE3 CHPF TRAPPC9 ELL	3.96e-06	195	107	8	1298_UP
Drug	CP-690334-01 [459212-38-5]; Down 200; 1uM; MCF7; HT_HG-U133A	PI4K2A ADARB1 ITPKB NEDD9 HEY1 NFKBIB ELL	3.84e-05	195	107	7	3909_DN
Drug	Thioperamide maleate [106243-16-7]; Down 200; 9.8uM; MCF7; HT_HG-U133A	THSD4 PI4K2A SFI1 MAST4 NFKBIB SCN10A ELL	3.84e-05	195	107	7	3392_DN
Drug	Isoconazole [27523-40-6]; Down 200; 9.6uM; PC3; HT_HG-U133A	TBC1D9B JMJD4 ANKZF1 NTAN1 MAST4 GNAS CHPF	3.97e-05	196	107	7	2056_DN
Drug	Pantothenic acid calcium salt monohydrate [63409-48-3]; Down 200; 8uM; MCF7; HT_HG-U133A	POLG ANKZF1 ADARB1 ITPKB NEDD9 RPAP1 NFKBIB	3.97e-05	196	107	7	3248_DN
Drug	Ceforanide [60925-61-3]; Up 200; 7.6uM; HL60; HT_HG-U133A	ENPP1 AFF3 PHC3 PTPRN2 NFKBIB MYO15A CEP170B	3.97e-05	196	107	7	2447_UP
Drug	Mifepristone [84371-65-3]; Down 200; 9.4uM; MCF7; HT_HG-U133A	JMJD4 SFI1 JAG2 PHC3 WDR6 NFKBIB TASOR	3.97e-05	196	107	7	7183_DN
Drug	Berberine chloride [633-65-8]; Down 200; 10.8uM; MCF7; HT_HG-U133A	JMJD4 SFI1 BTN2A1 MAST4 TLE3 SEC16A CHPF	4.10e-05	197	107	7	6791_DN
Drug	Arcaine sulfate [14923-17-2]; Down 200; 14.8uM; MCF7; HT_HG-U133A	POLG SFI1 BTN2A1 NEDD9 RPAP1 NFKBIB CHPF	4.10e-05	197	107	7	4974_DN
Drug	2-Chloropyrazine [14508-49-7]; Up 200; 35uM; PC3; HT_HG-U133A	THSD4 MAML1 AATK SH3PXD2A NFKBIB KAZALD1 ELL	4.10e-05	197	107	7	5750_UP
Drug	Acenocoumarol [152-72-7]; Down 200; 11.4uM; PC3; HT_HG-U133A	TRAF3IP2 TBC1D9B POLG ANKZF1 NEDD9 TLE3 FAM222B	4.23e-05	198	107	7	5878_DN
Drug	Disopyramide [3737-09-5]; Up 200; 11.8uM; MCF7; HT_HG-U133A	TRAF3IP2 SFI1 ANKZF1 ITPKB MAST4 NFKBIB TASOR	4.37e-05	199	107	7	7439_UP
Drug	Anabasine [494-52-0]; Down 200; 24.6uM; MCF7; HT_HG-U133A	PI4K2A ADARB1 ITPKB MAST4 NFKBIB KAZALD1 GNAS	4.37e-05	199	107	7	6074_DN
Drug	Tobramycin [32986-56-4]; Up 200; 8.6uM; HL60; HT_HG-U133A	RC3H2 ENPP1 ADARB1 SH3PXD2A NFKBIB SCN10A CHPF	4.51e-05	200	107	7	2481_UP
Drug	PHA-00851261E [724719-49-7]; Up 200; 1uM; MCF7; HT_HG-U133A	CLIP2 JMJD4 CHAT SFI1 AATK SH3PXD2A NFKBIB	4.51e-05	200	107	7	3968_UP
Drug	3,3'-diaminobenzidine	ENPP1 CHAT PTH CHPF	5.42e-05	44	107	4	CID000007071
Disease	Carcinoma, Pancreatic Ductal	CDKN2A JAG2 HEY1	7.70e-05	24	102	3	C0887833
Disease	Familial Atypical Mole Melanoma Syndrome	CDKN2A TERF2IP	6.38e-04	11	102	2	C2314896
Disease	Adrenal Gland Neoplasms	CDKN2A GNAS	6.38e-04	11	102	2	C0001624
Disease	Adrenal Cancer	CDKN2A GNAS	6.38e-04	11	102	2	C0750887
Disease	putamen volume change measurement	DCHS1 MYO16	9.00e-04	13	102	2	EFO_0021495
Disease	brain volume measurement	RELN TBC1D9B GINS1 HHIP MAST4 SH3PXD2A CORO6 HDAC10	1.09e-03	595	102	8	EFO_0006930
Disease	urate measurement, bone density	THSD4 ITPKB NEDD9 MAST4 PTPRN2 SEC16A HELZ2 MYO16	1.40e-03	619	102	8	EFO_0003923, EFO_0004531
Disease	brain measurement, neuroimaging measurement	THSD4 JAG2 HHIP NTAN1 MAST4 SH3PXD2A CORO6	3.03e-03	550	102	7	EFO_0004346, EFO_0004464
Disease	blood phosphate measurement	ENPP1 SGPP2 PTH ELL	3.17e-03	174	102	4	EFO_0010972
Disease	comparative body size at age 10, self-reported	RELN HHIP AATK MAST4 C12orf42 GNAS	3.43e-03	420	102	6	EFO_0009819

Protein segments in the cluster

Peptide	Gene	Start	Entry
APLRADGDKPRAHLT	TNFSF15	86	O95150
NCHRPEEPAAADALG	AFF3	601	P51826
RQVDADLQPAGSLPH	CHTF18	81	Q8WVB6
APARSCREAEGLAHP	AMER2	276	Q8N7J2
LAGENLPPHQAEDAR	DISP3	1261	Q9P2K9
PRAHDPLADVSNDLG	ELL	391	P55199
CDIPGAAEPVARRHQ	NEDD9	281	Q14511
TNHVDRLDPALIRPG	BCS1L	331	Q9Y276
TEAGRAQDPGEPREH	CD5	216	P06127
DSEGRLQADPQRFPH	GLA	101	P06280
LLEANRHSPGPERDL	CLIP2	916	Q9UDT6
HEAPRGAFRLAAENP	AP5S1	91	Q9NUS5
NDPSLLHRVGPGDDR	CEP170B	321	Q9Y4F5
LAERAHLQPREEPGA	DENND1C	756	Q8IV53
RHGEEQPPILNADAA	ADNP2	991	Q6IQ32
AAPRAAARAHEEPPG	TFAP2E	101	Q6VUC0
TGDPANLNRLRPHLE	RC3H2	341	Q9HBD1
IRQRLLAEGHPDPDA	RBM25	546	P49756
HAIPGARFALPNARD	PCDHGA11	146	Q9Y5H2
ARTHTAQDRPPAEGD	PTPRN2	171	Q92932
RLDAADGPEHGRPAT	MAML1	91	Q92585
GPAALHVVARDPDLG	DCHS1	1561	Q96JQ0
LGPLHAAAAAAAPRR	NKX2-4	176	Q9H2Z4
AARARPDANLTVAHP	KAZALD1	151	Q96I82
RQVAGPGAAAAHLPR	KAAG1	26	Q9UBP8
PPVRARSADHGEDAL	MYO15A	2991	Q9UKN7
AAREAANEALARPRP	MYO16	1321	Q9Y6X6
ADEALPGPAGHAAVR	JAG2	1161	Q9Y219
VRHLLGRGADPDASP	ASB18	136	Q6ZVZ8
LPAAARARNGATPAH	ESPN	61	B1AK53
IHDELSRAARAPDGP	FAM89B	51	Q8N5H3
NPILARLLRAHGAPE	NFKBIB	286	Q15653
KAHRAPGNRAPDPTE	FAM222B	536	Q8WU58
RRPLHDSAALDPLQA	TCF12	166	Q99081
ALLGPGADHPQDLRD	LRRC14B	66	A6NHZ5
RGRSHAAEAPGDPQA	ENPP1	31	P22413
GKLFHAREGPARPEN	LMNTD2	536	Q8IXW0
AAADIPQPAVRHQGR	FAM90A17	206	P0DV74
DSIEDPNSPAGRRHL	HOOK3	231	Q86VS8
EPADRHPNRKARGQL	ADARB1	506	P78563
AAADIPQPAVRHQGR	FAM90A16	206	P0DV73
PSGPDGAAREHILRQ	PHC3	841	Q8NDX5
QHERSPADAGPVGRI	RELN	2681	P78509
SPGHDRERQPLLDRA	PI4K2A	51	Q9BTU6
AAADIPQPAVRHQGR	FAM90A8	206	A6NJQ4
RAGEELARPLGHSPA	EEF1DP3	96	Q658K8
NHARIDAAEGPSDIP	CDKN2A	141	P42771
PAHRAGLRPGDVILA	HTRA2	401	O43464
LGQLDRPPDLAHDGR	HDAC10	511	Q969S8
GVLGDRANPDLRAHP	CCDC107	21	Q8WV48
RANPDLRAHPGNAAH	CCDC107	26	Q8WV48
LVSHAPGEALARAPR	ANKZF1	31	Q9H8Y5
PLGPSAAAEVRAQVH	PDSS1	31	Q5T2R2
AAAAGGPQRIPAHRF	BTBD1	81	Q9H0C5
LFPPGQEEALRDRHG	JMJD4	256	Q9H9V9
VPVARLHGALPDARG	IFNL2	26	Q8IZJ0
GQPEARALHPAAVSA	CEP170P1	246	Q96L14
AEQARPHEGARPLRA	CORO6	211	Q6QEF8
RHLGESVPDNPERFD	BTN2A1	356	Q7KYR7
APSNRDHRKAQPAGE	MAST4	2496	O15021
ANDNAPEHALRPGFL	LAMTOR3	36	Q9UHA4
QGRLGSAHPEAPALR	HEY1	216	Q9Y5J3
RQQPADAAARPGVHE	EMILIN1	221	Q9Y6C2
ALEKAGLPRRDPAGH	DGLUCY	131	Q7Z3D6
RQHPGAGRELPARLD	HELZ2	1466	Q9BYK8
GLVAQHPPARRSGAE	C7orf50	86	Q9BRJ6
LNPREALEGRHPQDG	SCAP	661	Q12770
QELRAASEHRGPPQD	PTX4	211	Q96A99
LAEEASFRRPHPDGD	HSFX1	71	Q9UBD0
AAAAQPIGHPDALER	POLG	86	A0A3B3IS91
PIGHPDALERAARAN	POLG	91	A0A3B3IS91
VPAAAPDAGAPHDRQ	TAF5	81	Q15542
PDAGAPHDRQTLLAV	TAF5	86	Q15542
RPLGALGRLAAEEPH	SFI1	981	A8K8P3
FIRLEEAAPAAGHDP	AATK	531	Q6ZMQ8
PARDANDPVDDRHAP	PRPF6	36	O94906
NDPVDDRHAPPGKRT	PRPF6	41	O94906
EAEQLSHQAAPGPRR	RECQL4	881	O94761
HRPQDLALTEPSGRA	ITPKB	316	P27987
ETRAAHVAPAAPDAG	GNAS	481	Q5JWF2
AVVRHSDAPGLPNGR	ERCC5	506	P28715
GLAQHREGAAPAAAP	SAMD11	271	Q96NU1
AGDLVRAHPPLEERA	NTAN1	16	Q96AB6
LHQRLGDVEGAAPAP	REELD1	186	A0A1B0GV85
DPGRCAVDRHPTDIN	HHIP	431	Q96QV1
FVREADPQLGPHADL	SCMH1	601	Q96GD3
RAARVPGVEHLPAAN	SGPP2	41	Q8IWX5
PQPIGSLGHDADLRR	TASOR	741	Q9UK61
LHQDAARELQPPAAG	TBC1D9B	1091	Q66K14
QPHRNRAGLDLPTID	TRAF3IP2	191	O43734
PHLEGCRNDIVSARP	CHPF	261	Q8IZ52
RAISAQEAHAPGRLP	CHST13	136	Q8NET6
SAEAAEPRRAGPHLC	CHAT	86	P28329
PAGAQAHPDDIQSRL	C12orf42	251	Q96LP6
RPRHEGNAPDLACNF	MRPL9	31	Q9BYD2
RGPSRADPNHLVDDL	VPS4B	366	O75351
VRPHLLAAEGPAAQE	PHETA2	96	Q6ICB4
REAHRQAALARPAVP	MISP3	71	Q96FF7
GLDRPLSRQNPHDGV	SEC16A	181	O15027
EHRPASALVNPLARG	SEC16A	326	O15027
APRGPRDEHSDFIAN	SCN10A	976	Q9Y5Y9
VEDRASGERRPAQPH	SH3PXD2A	576	Q5TCZ1
LHTRAEAEAPRAPGL	ZSCAN1	186	Q8NBB4
GDSVAIPEPNLRLHR	TTC5	381	Q8N0Z6
LQSPREGPRNAEAAH	WDFY4	1491	Q6ZS81
RVDSDPPAQLRLLHG	SIGLEC1	1006	Q9BZZ2
GDANSDRPPLQDHRD	RPAP1	41	Q9BWH6
HGFRVRPEPNGDLDL	WDR6	66	Q9NNW5
DALAGPGIPRHARQI	TLE3	466	Q04726
RNGFRDDADLPPHPR	ZNF229	271	Q9UJW7
GRPHPRALAAEEIRQ	WRNIP1	206	Q96S55
PNGHRPQLRAASGED	WASHC2A	1076	Q641Q2
LPAEAANRHRPGAQE	TRAPPC9	276	Q96Q05
ANRHRPGAQEVLIDP	TRAPPC9	281	Q96Q05
QRPGAPARAFADHVV	THSD4	91	Q6ZMP0
DVHNFVALGAPLAPR	PTH	61	P01270
RELHRAPEGQLPAFN	GINS1	11	Q14691
GALAEGAAEPEPQRH	TERF2IP	116	Q9NYB0
GAAEPEPQRHAGRIA	TERF2IP	121	Q9NYB0
PRPNGDPAAAALAHE	KCNC3	661	Q14003