Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	metal ion transmembrane transporter activity	SLC11A2 ASIC1 TRPC6 SLC1A3 TFRC SLC9A2 KCNT2 KCNB1 SCN5A PKD1 ATP2B2 ATP2B4 KCNT1 KCNH5	6.76e-05	465	176	14	GO:0046873
GeneOntologyMolecularFunction	oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor	GLUD1 GLUD2	7.73e-05	2	176	2	GO:0016639
GeneOntologyMolecularFunction	glutamate dehydrogenase [NAD(P)+] activity	GLUD1 GLUD2	7.73e-05	2	176	2	GO:0004353
GeneOntologyMolecularFunction	glutamate dehydrogenase (NAD+) activity	GLUD1 GLUD2	7.73e-05	2	176	2	GO:0004352
GeneOntologyMolecularFunction	glutamate dehydrogenase (NADP+) activity	GLUD1 GLUD2	7.73e-05	2	176	2	GO:0004354
GeneOntologyMolecularFunction	intracellular sodium-activated potassium channel activity	KCNT2 KCNT1	7.73e-05	2	176	2	GO:0005228
GeneOntologyMolecularFunction	calmodulin binding	MYO1A PHKG1 NDUFAF4 PPP3CC SCN5A ASPM ATP2B2 ATP2B4 KCNH5	2.10e-04	230	176	9	GO:0005516
GeneOntologyMolecularFunction	inorganic cation transmembrane transporter activity	SLC11A2 ASIC1 TRPC6 SLC1A3 TFRC SLC9A2 KCNT2 KCNB1 SLC45A3 SCN5A PKD1 ATP2B2 ATP2B4 KCNT1 KCNH5	4.55e-04	627	176	15	GO:0022890
GeneOntologyMolecularFunction	mediator complex binding	SMC1A SMC3	4.58e-04	4	176	2	GO:0036033
GeneOntologyMolecularFunction	NAD+ binding	PARP14 GLUD1 GLUD2	6.87e-04	20	176	3	GO:0070403
GeneOntologyMolecularFunction	cytoskeleton-nuclear membrane anchor activity	SYNE1 SYNE2	7.59e-04	5	176	2	GO:0140444
GeneOntologyMolecularFunction	monoatomic cation transmembrane transporter activity	SLC11A2 ASIC1 TRPC6 SLC1A3 TFRC SLC9A2 KCNT2 KCNB1 SLC45A3 SCN5A PKD1 ATP2B2 ATP2B4 KCNT1 KCNH5	8.19e-04	664	176	15	GO:0008324
GeneOntologyBiologicalProcess	microtubule-based movement	CFAP47 KIF27 KIF1A SPEF2 TTLL5 GAS8 APOB CFAP43 AP3B1 FSIP2 AGBL4 NETO1 SYNE2 VAMP7 DNAH6 ATP2B4 HYDIN HTT	2.25e-07	493	175	18	GO:0007018
GeneOntologyBiologicalProcess	microtubule-based process	CFAP47 TPR KIF27 KIF1A SMC1A SPEF2 TTLL5 GAS8 BRSK2 APOB CFAP43 AP3B1 LYST FSIP2 AGBL4 BNIP2 CCDC42 SMC3 NETO1 SYNE2 VAMP7 PKD1 ASPM DNAH6 ATP2B4 HYDIN HTT	2.94e-07	1058	175	27	GO:0007017
GeneOntologyBiologicalProcess	intracellular transport	THOC1 TPR EXOC6 IPO7 KIF1A ZFYVE16 ABCA12 SYNE1 BRSK2 LAMP2 AKIRIN2 AP3B1 LYST AKAP8L SCYL2 PIKFYVE AGBL4 AP4E1 ARL4C ARL1 NETO1 SYNE2 NUP210 VAMP7 PKD1 TRAPPC10 AP1M1 AKAP13 SCFD1 LRBA HTT DOP1A	1.06e-06	1496	175	32	GO:0046907
GeneOntologyBiologicalProcess	dicarboxylic acid biosynthetic process	KMO GLUD1 GLUD2 HTT	8.42e-06	16	175	4	GO:0043650
GeneOntologyBiologicalProcess	non-proteinogenic amino acid metabolic process	ALDH8A1 SLC1A3 KMO AGXT2 ATP2B4 HTT CRTAP	9.27e-06	87	175	7	GO:0170041
GeneOntologyBiologicalProcess	sperm axoneme assembly	CFAP47 SPEF2 TTLL5 CFAP43 FSIP2	9.46e-06	34	175	5	GO:0007288
GeneOntologyBiologicalProcess	microtubule-based transport	KIF27 KIF1A SPEF2 GAS8 CFAP43 AP3B1 AGBL4 NETO1 SYNE2 VAMP7 HTT	1.11e-05	253	175	11	GO:0099111
GeneOntologyBiologicalProcess	organelle assembly	CFAP47 TPR MOSPD2 KIF27 SYNE1 SMC1A SPEF2 TTLL5 GAS8 RNF213 CFAP43 AP3B1 PIKFYVE FSIP2 CCDC42 SMC3 TBC1D1 SYNE2 ASPM AP1M1 AKAP13 SCFD1 LRBA HYDIN HTT	1.19e-05	1138	175	25	GO:0070925
GeneOntologyBiologicalProcess	cilium movement	CFAP47 KIF27 SPEF2 TTLL5 GAS8 APOB CFAP43 FSIP2 DNAH6 ATP2B4 HYDIN	1.49e-05	261	175	11	GO:0003341
GeneOntologyBiologicalProcess	axoneme assembly	CFAP47 SPEF2 TTLL5 GAS8 CFAP43 FSIP2 HYDIN	4.04e-05	109	175	7	GO:0035082
GeneOntologyBiologicalProcess	plasma membrane bounded cell projection assembly	CFAP47 RAP1A RAP1B AKIRIN1 KIF27 MYO1A SYNE1 SPEF2 TTLL5 GAS8 CFAP43 FSIP2 CCDC42 TBC1D1 SYNE2 HYDIN HTT	5.90e-05	670	175	17	GO:0120031
GeneOntologyBiologicalProcess	intracellular protein transport	TPR EXOC6 IPO7 KIF1A ZFYVE16 ABCA12 BRSK2 LAMP2 AKIRIN2 AP3B1 AP4E1 ARL4C ARL1 NETO1 VAMP7 PKD1 AP1M1 SCFD1	6.11e-05	740	175	18	GO:0006886
GeneOntologyBiologicalProcess	cell projection assembly	CFAP47 RAP1A RAP1B AKIRIN1 KIF27 MYO1A SYNE1 SPEF2 TTLL5 GAS8 CFAP43 FSIP2 CCDC42 TBC1D1 SYNE2 HYDIN HTT	7.73e-05	685	175	17	GO:0030031
GeneOntologyBiologicalProcess	cilium movement involved in cell motility	CFAP47 SPEF2 TTLL5 GAS8 APOB CFAP43 FSIP2 DNAH6 ATP2B4	7.94e-05	210	175	9	GO:0060294
GeneOntologyBiologicalProcess	cilium-dependent cell motility	CFAP47 SPEF2 TTLL5 GAS8 APOB CFAP43 FSIP2 DNAH6 ATP2B4	9.50e-05	215	175	9	GO:0060285
GeneOntologyBiologicalProcess	cilium or flagellum-dependent cell motility	CFAP47 SPEF2 TTLL5 GAS8 APOB CFAP43 FSIP2 DNAH6 ATP2B4	9.50e-05	215	175	9	GO:0001539
GeneOntologyBiologicalProcess	motile cilium assembly	CFAP47 SPEF2 TTLL5 CFAP43 FSIP2 HTT	1.04e-04	88	175	6	GO:0044458
GeneOntologyBiologicalProcess	sperm flagellum assembly	CFAP47 SPEF2 TTLL5 CFAP43 FSIP2	1.12e-04	56	175	5	GO:0120316
GeneOntologyBiologicalProcess	cilium assembly	CFAP47 KIF27 SYNE1 SPEF2 TTLL5 GAS8 CFAP43 FSIP2 CCDC42 TBC1D1 SYNE2 HYDIN HTT	1.12e-04	444	175	13	GO:0060271
GeneOntologyBiologicalProcess	metal ion transport	SLC11A2 ASIC1 TRPC6 LCN2 SLC1A3 TFRC PTPN6 SLC9A2 PPP3CC KCNT2 KCNB1 NETO1 SCN5A PKD1 METTL21C IKBKB ATP2B2 ATP2B4 KCNT1 HTT KCNH5	1.19e-04	1000	175	21	GO:0030001
GeneOntologyBiologicalProcess	antigen processing and presentation of exogenous antigen	PSME2 AP3B1 PIKFYVE LNPEP IKBKB	1.32e-04	58	175	5	GO:0019884
GeneOntologyBiologicalProcess	microtubule cytoskeleton organization	CFAP47 TPR SMC1A SPEF2 TTLL5 GAS8 BRSK2 CFAP43 FSIP2 BNIP2 CCDC42 SMC3 SYNE2 PKD1 ASPM HYDIN HTT	1.41e-04	720	175	17	GO:0000226
GeneOntologyBiologicalProcess	monoatomic cation transmembrane transport	SLC11A2 ASIC1 TRPC6 LCN2 SLC1A3 PTPN6 SLC9A2 PPP3CC KCNT2 KCNB1 NETO1 SCN5A PKD1 METTL21C IKBKB ATP2B2 ATP2B4 KCNT1 HTT KCNH5	1.51e-04	942	175	20	GO:0098655
GeneOntologyBiologicalProcess	organelle transport along microtubule	KIF1A AP3B1 AGBL4 SYNE2 VAMP7 HTT	1.79e-04	97	175	6	GO:0072384
GeneOntologyBiologicalProcess	flagellated sperm motility	CFAP47 SPEF2 TTLL5 GAS8 APOB CFAP43 FSIP2 ATP2B4	1.94e-04	186	175	8	GO:0030317
GeneOntologyBiologicalProcess	cilium organization	CFAP47 KIF27 SYNE1 SPEF2 TTLL5 GAS8 CFAP43 FSIP2 CCDC42 TBC1D1 SYNE2 HYDIN HTT	2.21e-04	476	175	13	GO:0044782
GeneOntologyBiologicalProcess	microtubule bundle formation	CFAP47 SPEF2 TTLL5 GAS8 CFAP43 FSIP2 HYDIN	2.43e-04	145	175	7	GO:0001578
GeneOntologyBiologicalProcess	sperm motility	CFAP47 SPEF2 TTLL5 GAS8 APOB CFAP43 FSIP2 ATP2B4	2.49e-04	193	175	8	GO:0097722
GeneOntologyBiologicalProcess	alpha-amino acid catabolic process	ALDH8A1 KMO AGXT2 GLUD1 GLUD2 ATP2B4	2.61e-04	104	175	6	GO:1901606
GeneOntologyBiologicalProcess	alpha-amino acid metabolic process	ALDH8A1 KMO AGXT2 ADSS2 GLUD1 GLUD2 ATP2B4 HTT CRTAP	3.03e-04	251	175	9	GO:1901605
GeneOntologyBiologicalProcess	inorganic cation transmembrane transport	SLC11A2 ASIC1 TRPC6 LCN2 SLC1A3 PTPN6 SLC9A2 PPP3CC KCNT2 KCNB1 NETO1 SCN5A PKD1 METTL21C ATP2B2 ATP2B4 KCNT1 HTT KCNH5	3.24e-04	922	175	19	GO:0098662
GeneOntologyBiologicalProcess	melanosome organization	AP3B1 LYST PIKFYVE AP1M1	3.27e-04	39	175	4	GO:0032438
GeneOntologyBiologicalProcess	organelle localization	EXOC6 MYO1A KIF1A SYNE1 BRSK2 AP3B1 MFN1 AGBL4 KCNB1 SYNE2 MAD1L1 VAMP7 PKD1 ASPM TRAPPC10 HTT	3.35e-04	703	175	16	GO:0051640
GeneOntologyBiologicalProcess	pigment granule organization	AP3B1 LYST PIKFYVE AP1M1	3.61e-04	40	175	4	GO:0048753
GeneOntologyBiologicalProcess	L-amino acid metabolic process	ALDH8A1 KMO AGXT2 ADSS2 GLUD1 GLUD2 ATP2B4 CRTAP	4.12e-04	208	175	8	GO:0170033
GeneOntologyBiologicalProcess	intracellular chemical homeostasis	SLC11A2 ABCA12 TRPC6 BRSK2 LAMP2 LCN2 AP3B1 SLC1A3 TFRC PTPN6 SLC9A2 KCNB1 TBC1D1 METTL21C NKX6-1 ATP2B2 ATP2B4 HTT	4.23e-04	866	175	18	GO:0055082
GeneOntologyBiologicalProcess	nuclear matrix organization	TPR SYNE1	4.25e-04	4	175	2	GO:0043578
GeneOntologyBiologicalProcess	establishment of meiotic sister chromatid cohesion	SMC1A SMC3	4.25e-04	4	175	2	GO:0034089
GeneOntologyBiologicalProcess	amino acid catabolic process	ALDH8A1 KMO AGXT2 GLUD1 GLUD2 ATP2B4	4.92e-04	117	175	6	GO:0009063
GeneOntologyBiologicalProcess	amino acid metabolic process	ALDH8A1 SLC1A3 KMO AGXT2 ADSS2 GLUD1 GLUD2 ATP2B4 HTT CRTAP	5.61e-04	332	175	10	GO:0006520
GeneOntologyBiologicalProcess	L-amino acid catabolic process	ALDH8A1 AGXT2 GLUD1 GLUD2 ATP2B4	5.97e-04	80	175	5	GO:0170035
GeneOntologyCellularComponent	motile cilium	CFAP47 RAP1A SPEF2 PRAMEF20 GAS8 PRAMEF12 CFAP43 USP26 FSIP2 PPP3CC CCDC42 PKD1 DNAH6 ATP2B4	1.99e-06	355	176	14	GO:0031514
GeneOntologyCellularComponent	cilium	CFAP47 RAP1A PDE6A KIF27 SPEF2 TTLL5 PRAMEF20 GAS8 PCDHB8 PRAMEF12 CFAP43 USP26 FSIP2 AGBL4 PPP3CC CCDC42 PKD1 DNAH6 ATP2B2 ATP2B4 HYDIN	2.31e-05	898	176	21	GO:0005929
GeneOntologyCellularComponent	9+2 motile cilium	RAP1A SPEF2 GAS8 CFAP43 USP26 FSIP2 PPP3CC CCDC42 DNAH6 ATP2B4	3.53e-05	238	176	10	GO:0097729
GeneOntologyCellularComponent	perinuclear region of cytoplasm	EXOC6 RAP1A SLC11A2 KIF1A SYNE1 USP29 BRSK2 LAMP2 SLC1A3 TFRC PIKFYVE BNIP2 KCNB1 CCDC42 LNPEP SCN5A VAMP7 AKAP13 COPS6 HTT	1.22e-04	934	176	20	GO:0048471
GeneOntologyCellularComponent	trans-Golgi network	SLC11A2 NBEA LAMP2 AP3B1 AP4E1 ARL1 VAMP7 AP1M1 LRBA DOP1A	2.79e-04	306	176	10	GO:0005802
GeneOntologyCellularComponent	sperm head-tail coupling apparatus	CFAP47 FSIP2 CCDC42	4.36e-04	18	176	3	GO:0120212
GeneOntologyCellularComponent	mitotic spindle pole	SMC1A SMC3 MAD1L1 ASPM	4.64e-04	43	176	4	GO:0097431
GeneOntologyCellularComponent	sperm flagellum	RAP1A SPEF2 GAS8 USP26 FSIP2 PPP3CC CCDC42 ATP2B4	4.73e-04	214	176	8	GO:0036126
Domain	ARM-type_fold	IPO7 VEPH1 SCYL3 USP24 NBEA APOB AP3B1 LYST SCYL2 FOCAD AP4E1 ASPM LRBA HTT	3.22e-06	339	172	14	IPR016024
Domain	PH_BEACH	NBEA LYST LRBA	1.50e-05	6	172	3	PF14844
Domain	PH-BEACH_dom	NBEA LYST LRBA	4.15e-05	8	172	3	IPR023362
Domain	-	NBEA LYST LRBA	4.15e-05	8	172	3	2.30.29.40
Domain	PH_BEACH	NBEA LYST LRBA	4.15e-05	8	172	3	PS51783
Domain	CH	CFAP47 SYNE1 SPEF2 SYNE2 ASPM PLS3	5.71e-05	73	172	6	PS50021
Domain	BEACH	NBEA LYST LRBA	6.19e-05	9	172	3	PS50197
Domain	Beach	NBEA LYST LRBA	6.19e-05	9	172	3	PF02138
Domain	-	NBEA LYST LRBA	6.19e-05	9	172	3	1.10.1540.10
Domain	Beach	NBEA LYST LRBA	6.19e-05	9	172	3	SM01026
Domain	BEACH_dom	NBEA LYST LRBA	6.19e-05	9	172	3	IPR000409
Domain	CH-domain	CFAP47 SYNE1 SPEF2 SYNE2 ASPM PLS3	6.65e-05	75	172	6	IPR001715
Domain	ELFV_dehydrog_N	GLUD1 GLUD2	8.43e-05	2	172	2	PF02812
Domain	Vitellinogen_b-sht_N	APOB MTTP	8.43e-05	2	172	2	IPR015816
Domain	Lipid_transp_b-sht_shell	APOB MTTP	8.43e-05	2	172	2	IPR015819
Domain	Glu/Leu/Phe/Val_DH_C	GLUD1 GLUD2	8.43e-05	2	172	2	IPR006096
Domain	Glu/Leu/Phe/Val_DH_dimer_dom	GLUD1 GLUD2	8.43e-05	2	172	2	IPR006097
Domain	Glu/Leu/Phe/Val_DH	GLUD1 GLUD2	8.43e-05	2	172	2	IPR006095
Domain	ELFV_dehydrog	GLUD1 GLUD2	8.43e-05	2	172	2	PF00208
Domain	-	APOB MTTP	8.43e-05	2	172	2	2.30.230.10
Domain	DUF1088	NBEA LRBA	8.43e-05	2	172	2	IPR010508
Domain	VITELLOGENIN	APOB MTTP	8.43e-05	2	172	2	PS51211
Domain	ASH	ASPM HYDIN	8.43e-05	2	172	2	IPR031549
Domain	NAD_bind_Glu_DH	GLUD1 GLUD2	8.43e-05	2	172	2	IPR033922
Domain	Akirin	AKIRIN1 AKIRIN2	8.43e-05	2	172	2	IPR024132
Domain	GLFV_DEHYDROGENASE	GLUD1 GLUD2	8.43e-05	2	172	2	PS00074
Domain	LPD_N	APOB MTTP	8.43e-05	2	172	2	SM00638
Domain	Lipid_transpt_N	APOB MTTP	8.43e-05	2	172	2	IPR001747
Domain	ELFV_dehydrog	GLUD1 GLUD2	8.43e-05	2	172	2	SM00839
Domain	Glu/Leu/Phe/Val_DH_AS	GLUD1 GLUD2	8.43e-05	2	172	2	IPR033524
Domain	-	APOB MTTP	8.43e-05	2	172	2	1.25.10.20
Domain	ASH	ASPM HYDIN	8.43e-05	2	172	2	PF15780
Domain	Vitellogenin_N	APOB MTTP	8.43e-05	2	172	2	PF01347
Domain	DUF1088	NBEA LRBA	8.43e-05	2	172	2	PF06469
Domain	P-loop_NTPase	RAP1A RAP1B KIF27 MYO1A KIF1A ABCA12 SMC1A SPEF2 RNF213 LRRK1 MFN1 ARL4C ARL1 ADSS2 RRAGD SMC3 ASPM DDX60L DNAH6 HYDIN	1.09e-04	848	172	20	IPR027417
Domain	Vitellinogen_superhlx	APOB MTTP	2.51e-04	3	172	2	IPR011030
Domain	USP37-like_PH	USP29 USP26	2.51e-04	3	172	2	IPR032069
Domain	UCH_N	USP29 USP26	2.51e-04	3	172	2	PF16674
Domain	CH	CFAP47 SYNE1 SYNE2 ASPM PLS3	4.66e-04	70	172	5	PF00307
Domain	-	CFAP47 SYNE1 SYNE2 ASPM PLS3	4.98e-04	71	172	5	1.10.418.10
Domain	ATP_Ca_trans_C	ATP2B2 ATP2B4	5.00e-04	4	172	2	IPR022141
Domain	KASH	SYNE1 SYNE2	5.00e-04	4	172	2	IPR012315
Domain	Rpn11/EIF3F_C	PSMD7 COPS6	5.00e-04	4	172	2	IPR024969
Domain	ATP_Ca_trans_C	ATP2B2 ATP2B4	5.00e-04	4	172	2	PF12424
Domain	KASH	SYNE1 SYNE2	5.00e-04	4	172	2	PS51049
Domain	MitMem_reg	PSMD7 COPS6	5.00e-04	4	172	2	PF13012
Domain	KASH	SYNE1 SYNE2	5.00e-04	4	172	2	SM01249
Domain	BK_channel_a	KCNT2 KCNT1	5.00e-04	4	172	2	PF03493
Domain	KASH	SYNE1 SYNE2	5.00e-04	4	172	2	PF10541
Domain	K_chnl_Ca-activ_BK_asu	KCNT2 KCNT1	5.00e-04	4	172	2	IPR003929
Domain	Prot_disulphide_isomerase	PDIA3 PDIA2	5.00e-04	4	172	2	IPR005792
Domain	P-type_ATPase_IIB	ATP2B2 ATP2B4	5.00e-04	4	172	2	IPR006408
Domain	PH_dom-like	MTMR12 KIF1A VEPH1 MTMR1 NBEA LYST TBC1D1 AKAP13 LRBA FRMD5 GAB1 FRMD3	6.03e-04	426	172	12	IPR011993
Domain	SMC	SMC1A SMC3	8.28e-04	5	172	2	IPR024704
Domain	DUF4704	NBEA LRBA	8.28e-04	5	172	2	IPR031570
Domain	DUF4704	NBEA LRBA	8.28e-04	5	172	2	PF15787
Domain	ARM-like	IPO7 SCYL3 NBEA AP3B1 SCYL2 AP4E1 ASPM LRBA HTT	9.14e-04	270	172	9	IPR011989
Domain	-	IPO7 SCYL3 AP3B1 SCYL2 AP4E1 ASPM LRBA HTT	1.07e-03	222	172	8	1.25.10.10
Domain	ACTININ_2	SYNE1 SYNE2 PLS3	1.19e-03	23	172	3	PS00020
Domain	ACTININ_1	SYNE1 SYNE2 PLS3	1.19e-03	23	172	3	PS00019
Domain	Actinin_actin-bd_CS	SYNE1 SYNE2 PLS3	1.19e-03	23	172	3	IPR001589
Domain	SMC_hinge	SMC1A SMC3	1.23e-03	6	172	2	SM00968
Domain	SMC_hinge	SMC1A SMC3	1.23e-03	6	172	2	PF06470
Domain	SMC_hinge	SMC1A SMC3	1.23e-03	6	172	2	IPR010935
Domain	GAF	PDE6A PDE6C	1.72e-03	7	172	2	PF01590
Domain	VWA	COL12A1 MATN1 COL6A5 PARP4	1.76e-03	56	172	4	PF00092
Domain	-	COL12A1 FAT3 NBEA FAT2 LRBA	1.86e-03	95	172	5	2.60.120.200
Domain	GAF	PDE6A PDE6C	2.28e-03	8	172	2	IPR003018
Domain	-	MOSPD2 HYDIN	2.28e-03	8	172	2	2.60.40.360
Domain	RecF/RecN/SMC_N	SMC1A SMC3	2.28e-03	8	172	2	IPR003395
Domain	SMC_N	SMC1A SMC3	2.28e-03	8	172	2	PF02463
Domain	GAF	PDE6A PDE6C	2.28e-03	8	172	2	SM00065
Domain	Disulphide_isomerase	PDIA3 PDIA2	2.28e-03	8	172	2	IPR005788
Domain	-	PDE6A PDE6C	2.91e-03	9	172	2	3.30.450.40
Domain	PapD-like	MOSPD2 HYDIN	2.91e-03	9	172	2	IPR008962
Domain	GAF_dom-like	PDE6A PDE6C	2.91e-03	9	172	2	IPR029016
Domain	CH	SYNE1 SYNE2 ASPM PLS3	3.04e-03	65	172	4	SM00033
Pubmed	BioID reveals an ATG9A interaction with ATG13-ATG101 in the degradation of p62/SQSTM1-ubiquitin clusters.	ZFYVE16 SCYL3 NBEA AP3B1 SLC1A3 TFRC SCYL2 PIKFYVE AP4E1 ARL1 BNIP2 LNPEP TRAPPC10 AP1M1 PEAK1 LRBA HTT	1.23e-13	285	176	17	34369648
Pubmed	Hepatitis B Virus HBx Protein Mediates the Degradation of Host Restriction Factors through the Cullin 4 DDB1 E3 Ubiquitin Ligase Complex.	CUL1 TPR RAP1A RAP1B PDE6A KIF27 RBL1 SMC1A RNF213 AP3B1 SMC3 SCFD1 LRBA IKBKB	5.86e-10	304	176	14	32235678
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	THOC1 CUL1 TPR RAP1B KIF27 IPO7 MLEC KIF1A SYNE1 SMC1A THUMPD3 PSMD7 APOB AP3B1 PDIA3 TFRC ADSS2 SMC3 NUP210 GLUD1 AP1M1 SCFD1 PEAK1 TDRD6 FLOT1 PLS3 DNMT1	3.62e-09	1425	176	27	30948266
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	MTMR12 MOSPD2 IPO7 ZFYVE16 SCYL3 MTMR1 RNF213 NBEA PSMD7 AP3B1 PDIA3 AKAP8L RCAN3 FBXO38 PTPN6 PPP3CC LNPEP SYNE2 NUP210 PEAK1 ATP2B4 GAB1 DNMT1	4.02e-09	1049	176	23	27880917
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	CASP8AP2 MOSPD2 IPO7 MLEC SYNE1 TTLL5 MTMR1 PSMD7 AP3B1 PIGU PDIA3 TFRC ARL1 NDUFAF4 LNPEP SYNE2 NUP210 GLUD1 ASPM AKAP13 SCFD1 PEAK1 FLOT1 ATP2B4 PLS3 GAB1 DNMT1	8.87e-09	1487	176	27	33957083
Pubmed	Proximity labelling identifies pro-migratory endocytic recycling cargo and machinery of the Rab4 and Rab11 families.	RAP1B ZFYVE16 SYNE1 SCYL3 TFRC SCYL2 BNIP2 LNPEP GLUD1 PEAK1 LRBA FLOT1 PLS3	2.17e-08	339	176	13	37232246
Pubmed	ER-export and ARFRP1/AP-1-dependent delivery of SARS-CoV-2 Envelope to lysosomes controls late stages of viral replication.	RAP1B MOSPD2 ASIC1 SCYL3 SLC1A3 PDIA3 TFRC SCYL2 PIKFYVE AP4E1 SMC3 LNPEP GLUD1 GLUD2 VAMP7 AP1M1 SCFD1 LRBA ATP2B4 SLC16A10	8.94e-08	952	176	20	38569033
Pubmed	BioID-based intact cell interactome of the Kv1.3 potassium channel identifies a Kv1.3-STAT3-p53 cellular signaling pathway.	TPR IPO7 MLEC ZFYVE16 SMC1A USP24 MTMR1 LAMP2 AP3B1 TFRC SCYL2 ADSS2 SMC3 PEAK1 LRBA PLS3 GAB1	1.37e-07	708	176	17	39231216
Pubmed	Systematically defining selective autophagy receptor-specific cargo using autophagosome content profiling.	RAP1A COL12A1 IPO7 MLEC ZFYVE16 THUMPD3 USP24 LAMP2 APOB PSME2 PDIA3 TFRC NDUFAF4 SMC3 LNPEP SYNE2 NUP210 AKAP13 IKBKB FLOT1 PLS3 DNMT1 CRTAP	1.90e-07	1297	176	23	33545068
Pubmed	A high-throughput approach for measuring temporal changes in the interactome.	CUL1 IPO7 FNTB SMC1A THUMPD3 USP24 LAMP2 PSMD7 PSME2 AP3B1 PDIA3 GTF3C4 BNIP2 ADSS2 LNPEP MAD1L1 PYGB AP1M1 LRBA IKBKB COPS6 PLS3 HTT CRTAP	3.73e-07	1455	176	24	22863883
Pubmed	Novel missense MTTP gene mutations causing abetalipoproteinemia.	APOB MTTP PDIA2	5.08e-07	4	176	3	25108285
Pubmed	The Functional Proximal Proteome of Oncogenic Ras Includes mTORC2.	SLC11A2 SCYL3 MTMR1 APOB PARP14 SLC1A3 TFRC LNPEP VAMP7 PEAK1 LRBA FLOT1 ATP2B4 GAB1	1.38e-06	569	176	14	30639242
Pubmed	Identification of Zika Virus and Dengue Virus Dependency Factors using Functional Genomics.	TPR RAP1A RAP1B MLEC TFRC SCYL2 SMC3 NUP210 PYGB SCFD1 FLOT1 ATP2B4	1.83e-06	422	176	12	27342126
Pubmed	C5orf51 is a component of the MON1-CCZ1 complex and controls RAB7A localization and stability during mitophagy.	MOSPD2 KIF1A ZFYVE16 SCYL3 NBEA PIGU LYST PIKFYVE LNPEP SYNE2 VAMP7 SCFD1 LRBA	1.98e-06	504	176	13	34432599
Pubmed	A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.	MTMR12 IPO7 MLEC KIF1A ZFYVE16 FNTB SMC1A MTMR1 PSMD7 AP3B1 PDIA3 TFRC PTPN6 SMC3 LNPEP NUP210 GLUD1 PLS3	2.53e-06	974	176	18	28675297
Pubmed	A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.	THOC1 CUL1 IPO7 MLEC RNF213 PSMD7 PSME2 PDIA3 AKAP8L TFRC NDUFAF4 ADSS2 SYNE2 NUP210 VAMP7 TRAPPC10 PNRC1 DDX60L SCFD1 IKBKB FLOT1 PLS3	4.12e-06	1440	176	22	30833792
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	PLXNA3 RAP1A RAP1B PDE6A MYO1A SYNE1 SPEF2 PSMD7 APOB LYST PDIA3 AKAP8L TFRC SYNE2 GLUD1 GLUD2 ASPM MTTP PDIA2 DNAH6 ATP2B2 DOP1A	4.21e-06	1442	176	22	35575683
Pubmed	The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation.	CUL1 IPO7 SMC1A USP24 PSMD7 AP3B1 TFRC SCYL2 SMC3 NUP210 AP1M1 SCFD1 LRBA PLS3	5.14e-06	638	176	14	33239621
Pubmed	HAPSTR1 localizes HUWE1 to the nucleus to limit stress signaling pathways.	THOC1 CUL1 IPO7 SMC1A THUMPD3 MTMR1 PSMD7 PSME2 GTF3C4 TFRC ARL1 COPS6 PLS3	7.63e-06	571	176	13	37167062
Pubmed	Defining the membrane proteome of NK cells.	MOSPD2 SLC11A2 IPO7 MLEC RNF213 PSMD7 PSME2 PARP14 AP3B1 PIGU PARP4 LNPEP NUP210 PYGB AP1M1 AKAP13 LRBA FLOT1 ATP2B4	8.18e-06	1168	176	19	19946888
Pubmed	A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity.	IPO7 SMC1A LAMP2 GTF3C4 SMC3 MAD1L1 METTL21C	9.68e-06	145	176	7	23349634
Pubmed	Evolutionarily conserved regulators of tau identify targets for new therapies.	RAP1A RAP1B SLC11A2 PSMD7 PDIA3 TFRC ARL1 ADSS2 NUP210 VAMP7 SCFD1 LRBA	1.40e-05	516	176	12	36610398
Pubmed	Cytoplasmic Metadherin (MTDH) provides survival advantage under conditions of stress by acting as RNA-binding protein.	PLXNA3 ABCA12 SYNE1 SPEF2 RNF213 ERICH6B NUP210 IKBKB	1.45e-05	214	176	8	22199357
Pubmed	IKK-Mediated Regulation of the COP9 Signalosome via Phosphorylation of CSN5.	CUL1 MLEC USP24 PDIA3 TFRC LRBA IKBKB COPS6	1.82e-05	221	176	8	31950832
Pubmed	SENP3 regulates the global protein turnover and the Sp1 level via antagonizing SUMO2/3-targeted ubiquitination and degradation.	CUL1 GTF3C4 TFRC MAD1L1 PYGB	1.88e-05	64	176	5	26511642
Pubmed	Functional synergy of a human-specific and an ape-specific metabolic regulator in human neocortex development.	SLC1A3 GLUD1 GLUD2	2.04e-05	11	176	3	38658571
Pubmed	Systematic identification of cancer cell vulnerabilities to natural killer cell-mediated immune surveillance.	CENPN ZFYVE16 SMC1A KIAA1586 SCYL2 SMC3 COPS6 PLS3	2.14e-05	226	176	8	31452512
Pubmed	C9orf72 protein quality control by UBR5-mediated heterotypic ubiquitin chains.	CUL1 RAP1A RAP1B IPO7 MLEC SMC1A PSMD7 AKAP8L GTF3C4 TFRC ARL1 NDUFAF4 SMC3 NUP210 GLUD1 GLUD2 PYGB AP1M1 COPS6	2.26e-05	1257	176	19	37317656
Pubmed	Cell volume changes regulate slick (Slo2.1), but not slack (Slo2.2) K+ channels.	KCNT2 KCNT1	2.55e-05	2	176	2	25347289
Pubmed	Rap1A and rap1B ras-family proteins are prominently expressed in the nucleus of squamous carcinomas: nuclear translocation of GTP-bound active form.	RAP1A RAP1B	2.55e-05	2	176	2	13679863
Pubmed	Rap1 promotes endothelial mechanosensing complex formation, NO release and normal endothelial function.	RAP1A RAP1B	2.55e-05	2	176	2	25807985
Pubmed	Akirins are highly conserved nuclear proteins required for NF-kappaB-dependent gene expression in drosophila and mice.	AKIRIN1 AKIRIN2	2.55e-05	2	176	2	18066067
Pubmed	Glutamate Delta-1 Receptor Regulates Inhibitory Neurotransmission in the Nucleus Accumbens Core and Anxiety-Like Behaviors.	GLUD1 GLUD2	2.55e-05	2	176	2	34173171
Pubmed	Glutamate dehydrogenase is essential to sustain neuronal oxidative energy metabolism during stimulation.	GLUD1 GLUD2	2.55e-05	2	176	2	28621566
Pubmed	GluD1 knockout mice with a pure C57BL/6N background show impaired fear memory, social interaction, and enhanced depressive-like behavior.	GLUD1 GLUD2	2.55e-05	2	176	2	32078638
Pubmed	Human placenta secretes apolipoprotein B-100-containing lipoproteins.	APOB MTTP	2.55e-05	2	176	2	15504742
Pubmed	Development of mice with brain-specific deletion of floxed glud1 (glutamate dehydrogenase 1) using cre recombinase driven by the nestin promoter.	GLUD1 GLUD2	2.55e-05	2	176	2	23595828
Pubmed	Nesprins: a novel family of spectrin-repeat-containing proteins that localize to the nuclear membrane in multiple tissues.	SYNE1 SYNE2	2.55e-05	2	176	2	11792814
Pubmed	Rap1 Is Essential for B-Cell Locomotion, Germinal Center Formation and Normal B-1a Cell Population.	RAP1A RAP1B	2.55e-05	2	176	2	34140948
Pubmed	Nesprin-1 and nesprin-2 regulate endothelial cell shape and migration.	SYNE1 SYNE2	2.55e-05	2	176	2	24931616
Pubmed	Mutations in cohesin complex members SMC3 and SMC1A cause a mild variant of cornelia de Lange syndrome with predominant mental retardation.	SMC1A SMC3	2.55e-05	2	176	2	17273969
Pubmed	Interaction between glutamate dehydrogenase (GDH) and L-leucine catabolic enzymes: intersecting metabolic pathways.	GLUD1 GLUD2	2.55e-05	2	176	2	21621574
Pubmed	Identification of the molecular dysfunction caused by glutamate dehydrogenase S445L mutation responsible for hyperinsulinism/hyperammonemia.	GLUD1 GLUD2	2.55e-05	2	176	2	28911206
Pubmed	The contribution of CYP2C gene subfamily involved in epoxygenase pathway of arachidonic acids metabolism to hypertension susceptibility in Russian population.	CYP2C19 CYP2C8	2.55e-05	2	176	2	28513222
Pubmed	Rap1B promotes VEGF-induced endothelial permeability and is required for dynamic regulation of the endothelial barrier.	RAP1A RAP1B	2.55e-05	2	176	2	29222111
Pubmed	Delineation of glutamate pathways and secretory responses in pancreatic islets with β-cell-specific abrogation of the glutamate dehydrogenase.	GLUD1 GLUD2	2.55e-05	2	176	2	22875990
Pubmed	Enhanced cortico-amygdala efficacy and suppressed fear in absence of Rap1.	RAP1A RAP1B	2.55e-05	2	176	2	18305243
Pubmed	Molecular basis of human glutamate dehydrogenase regulation under changing energy demands.	GLUD1 GLUD2	2.55e-05	2	176	2	15578726
Pubmed	A positively charged channel within the Smc1/Smc3 hinge required for sister chromatid cohesion.	SMC1A SMC3	2.55e-05	2	176	2	21139566
Pubmed	Important role of Ser443 in different thermal stability of human glutamate dehydrogenase isozymes.	GLUD1 GLUD2	2.55e-05	2	176	2	15044002
Pubmed	Microsomal triglyceride transfer protein gene expression and ApoB secretion are inhibited by bitter melon in HepG2 cells.	APOB MTTP	2.55e-05	2	176	2	15795421
Pubmed	Cornelia de Lange syndrome mutations in SMC1A or SMC3 affect binding to DNA.	SMC1A SMC3	2.55e-05	2	176	2	18996922
Pubmed	Induction of excitatory and inhibitory presynaptic differentiation by GluD1.	GLUD1 GLUD2	2.55e-05	2	176	2	22138648
Pubmed	Linkage disequilibrium between the CYP2C1917 and CYP2C82 alleles in populations of African descent.	CYP2C19 CYP2C8	2.55e-05	2	176	2	20890775
Pubmed	Glutamate Dehydrogenase Is Important for Ammonia Fixation and Amino Acid Homeostasis in Brain During Hyperammonemia.	GLUD1 GLUD2	2.55e-05	2	176	2	34220417
Pubmed	Mutation in RAP1 is a rare event in myelodysplastic syndromes.	RAP1A RAP1B	2.55e-05	2	176	2	16118622
Pubmed	Slack and Slick K(Na) channels regulate the accuracy of timing of auditory neurons.	KCNT2 KCNT1	2.55e-05	2	176	2	17344399
Pubmed	Modulation of adoptively transferred viable motheaten pathology in sublethally irradiated normal recipient mice by normal hematopoietic cells.	LYST PTPN6	2.55e-05	2	176	2	8093859
Pubmed	Expression of human GLUD1 and GLUD2 glutamate dehydrogenases in steroid producing tissues.	GLUD1 GLUD2	2.55e-05	2	176	2	26241911
Pubmed	A-kinase-anchoring protein-Lbc anchors IκB kinase β to support interleukin-6-mediated cardiomyocyte hypertrophy.	AKAP13 IKBKB	2.55e-05	2	176	2	23090968
Pubmed	Mutation analysis of RAP1 gene in papillary thyroid carcinomas.	RAP1A RAP1B	2.55e-05	2	176	2	18948674
Pubmed	Differential levels of glutamate dehydrogenase 1 (GLUD1) in Balb/c and C57BL/6 mice and the effects of overexpression of the Glud1 gene on glutamate release in striatum.	GLUD1 GLUD2	2.55e-05	2	176	2	21446915
Pubmed	Microdiversity of human-plasma-membrane calcium-pump isoform 2 generated by alternative RNA splicing in the N-terminal coding region.	ATP2B2 ATP2B4	2.55e-05	2	176	2	1313367
Pubmed	Expression of Rap 1 suppresses genomic instability of H-ras transformed mouse fibroblasts.	RAP1A RAP1B	2.55e-05	2	176	2	9330640
Pubmed	A deficiency of microsomal triglyceride transfer protein reduces apolipoprotein B secretion.	APOB MTTP	2.55e-05	2	176	2	10713055
Pubmed	Rap1 GTPase activation and barrier enhancement in rpe inhibits choroidal neovascularization in vivo.	RAP1A RAP1B	2.55e-05	2	176	2	24039860
Pubmed	Overexpression of exogenous kidney-specific Ngal attenuates progressive cyst development and prolongs lifespan in a murine model of polycystic kidney disease.	LCN2 PKD1	2.55e-05	2	176	2	28341240
Pubmed	Gut-derived GIP activates central Rap1 to impair neural leptin sensitivity during overnutrition.	RAP1A RAP1B	2.55e-05	2	176	2	31403469
Pubmed	GluD1 binds GABA and controls inhibitory plasticity.	GLUD1 GLUD2	2.55e-05	2	176	2	38060673
Pubmed	Gene expression patterns in the hippocampus during the development and aging of Glud1 (Glutamate Dehydrogenase 1) transgenic and wild type mice.	GLUD1 GLUD2	2.55e-05	2	176	2	24593767
Pubmed	Plasma membrane calcium pump (PMCA) isoform 4 is targeted to the apical membrane by the w-splice insert from PMCA2.	ATP2B2 ATP2B4	2.55e-05	2	176	2	22252018
Pubmed	Potentiation of neuronal activity by tonic GluD1 current in brain slices.	GLUD1 GLUD2	2.55e-05	2	176	2	37154294
Pubmed	Homozygous MTTP and APOB mutations may lead to hepatic steatosis and fibrosis despite metabolic differences in congenital hypocholesterolemia.	APOB MTTP	2.55e-05	2	176	2	24842304
Pubmed	Deletion of glutamate dehydrogenase 1 (Glud1) in the central nervous system affects glutamate handling without altering synaptic transmission.	GLUD1 GLUD2	2.55e-05	2	176	2	22924626
Pubmed	Plasma membrane Ca²⁺-ATPases can shape the pattern of Ca²⁺ transients induced by store-operated Ca²⁺ entry.	ATP2B2 ATP2B4	2.55e-05	2	176	2	25690014
Pubmed	Role of the small GTPase Rap1 for integrin activity regulation in endothelial cells and angiogenesis.	RAP1A RAP1B	2.55e-05	2	176	2	18805968
Pubmed	Analysis of genetically driven alternative splicing identifies FBXO38 as a novel COPD susceptibility gene.	CUL1 FBXO38	2.55e-05	2	176	2	31269066
Pubmed	Microsomal triglyceride transfer protein binding and lipid transfer activities are independent of each other, but both are required for secretion of apolipoprotein B lipoproteins from liver cells.	APOB MTTP	2.55e-05	2	176	2	11358959
Pubmed	Nerve tissue-specific (GLUD2) and housekeeping (GLUD1) human glutamate dehydrogenases are regulated by distinct allosteric mechanisms: implications for biologic function.	GLUD1 GLUD2	2.55e-05	2	176	2	11032875
Pubmed	The rap GTPases regulate B cell morphology, immune-synapse formation, and signaling by particulate B cell receptor ligands.	RAP1A RAP1B	2.55e-05	2	176	2	18191594
Pubmed	Evolution of the multifaceted eukaryotic akirin gene family.	AKIRIN1 AKIRIN2	2.55e-05	2	176	2	19200367
Pubmed	Cardiac Slo2.1 Is Required for Volatile Anesthetic Stimulation of K+ Transport and Anesthetic Preconditioning.	KCNT2 KCNT1	2.55e-05	2	176	2	26845140
Pubmed	Localization of Human Glutamate Dehydrogenases Provides Insights into Their Metabolic Role and Their Involvement in Disease Processes.	GLUD1 GLUD2	2.55e-05	2	176	2	29943084
Pubmed	Chromosome mapping of the human RAS-related RAP1A, RAP1B, and RAP2 genes to chromosomes 1p12----p13, 12q14, and 13q34, respectively.	RAP1A RAP1B	2.55e-05	2	176	2	2108841
Pubmed	Neutrophil gelatinase-associated lipocalin suppresses cyst growth by Pkd1 null cells in vitro and in vivo.	LCN2 PKD1	2.55e-05	2	176	2	18974761
Pubmed	Rap1a null mice have altered myeloid cell functions suggesting distinct roles for the closely related Rap1a and 1b proteins.	RAP1A RAP1B	2.55e-05	2	176	2	18056377
Pubmed	Huntingtin recruits KIF1A to transport synaptic vesicle precursors along the mouse axon to support synaptic transmission and motor skill learning.	KIF1A HTT	2.55e-05	2	176	2	37431882
Pubmed	Glutamate dehydrogenase deficiency disrupts glutamate homeostasis in hippocampus and prefrontal cortex and impairs recognition memory.	GLUD1 GLUD2	2.55e-05	2	176	2	31898404
Pubmed	Birth and adaptive evolution of a hominoid gene that supports high neurotransmitter flux.	GLUD1 GLUD2	2.55e-05	2	176	2	15378063
Pubmed	Widening Spectrum of Cellular and Subcellular Expression of Human GLUD1 and GLUD2 Glutamate Dehydrogenases Suggests Novel Functions.	GLUD1 GLUD2	2.55e-05	2	176	2	27422263
Pubmed	Rap1a is a key regulator of fibroblast growth factor 2-induced angiogenesis and together with Rap1b controls human endothelial cell functions.	RAP1A RAP1B	2.55e-05	2	176	2	18625726
Pubmed	Transient IKK2 activation in astrocytes initiates selective non-cell-autonomous neurodegeneration.	LCN2 IKBKB	2.55e-05	2	176	2	28193238
Pubmed	Multiple novel nesprin-1 and nesprin-2 variants act as versatile tissue-specific intracellular scaffolds.	SYNE1 SYNE2	2.55e-05	2	176	2	22768332
Pubmed	Critical role of the cysteine 323 residue in the catalytic activity of human glutamate dehydrogenase isozymes.	GLUD1 GLUD2	2.55e-05	2	176	2	15750346
Pubmed	Molecular cloning, structure and expression analysis of a full-length mouse brain glutamate dehydrogenase cDNA.	GLUD1 GLUD2	2.55e-05	2	176	2	1711373
Pubmed	Molecular mechanisms of Slo2 K+ channel closure.	KCNT2 KCNT1	2.55e-05	2	176	2	27682982
Pubmed	Structure-function analyses of microsomal triglyceride transfer protein missense mutations in abetalipoproteinemia and hypobetalipoproteinemia subjects.	APOB MTTP	2.55e-05	2	176	2	27487388
Pubmed	Identification of patients with abetalipoproteinemia and homozygous familial hypobetalipoproteinemia in Tunisia.	APOB MTTP	2.55e-05	2	176	2	19056372
Pubmed	Multi-ethnic distribution of clinically relevant CYP2C genotypes and haplotypes.	CYP2C19 CYP2C8	2.55e-05	2	176	2	22491019
Pubmed	Transcriptomic responses in mouse brain exposed to chronic excess of the neurotransmitter glutamate.	GLUD1 GLUD2	2.55e-05	2	176	2	20529287
Interaction	RAB11A interactions	TPR EXOC6 RAP1B ZFYVE16 ASIC1 SCYL3 NBEA LAMP2 SLC1A3 TFRC SCYL2 AP4E1 BNIP2 ADSS2 SMC3 LNPEP TBC1D1 SYNE2 VAMP7 TRAPPC10 SCFD1 PEAK1 LRBA FLOT1 PLS3 GAB1 HTT DOP1A	4.67e-10	830	172	28	int:RAB11A
Interaction	LAMTOR1 interactions	KIF1A ZFYVE16 SCYL3 NBEA LAMP2 AP3B1 SLC1A3 TFRC SCYL2 PIKFYVE AP4E1 ARL1 NDUFAF4 BNIP2 RRAGD LNPEP VAMP7 PEAK1 LRBA IKBKB FLOT1 ATP2B4 GAB1 HTT	1.24e-08	722	172	24	int:LAMTOR1
Interaction	ATG9A interactions	ZFYVE16 SCYL3 NBEA AP3B1 SLC1A3 TFRC SCYL2 PIKFYVE AP4E1 ARL1 BNIP2 LNPEP TRAPPC10 AP1M1 PEAK1 LRBA ATP2B2 HTT	5.27e-08	445	172	18	int:ATG9A
Interaction	RAB9A interactions	SLC11A2 KIF1A ZFYVE16 SMC1A SCYL3 NBEA LAMP2 TFRC SCYL2 PIKFYVE RRAGD SMC3 LNPEP SYNE2 VAMP7 SCFD1 PEAK1 LRBA ATP2B4 HTT	1.89e-07	595	172	20	int:RAB9A
Interaction	RAB4A interactions	RAP1B ZFYVE16 SYNE1 SCYL3 NBEA TFRC SCYL2 PIKFYVE AP4E1 LNPEP SYNE2 GLUD1 VAMP7 PEAK1 LRBA HTT	2.02e-06	457	172	16	int:RAB4A
Interaction	STX7 interactions	EXOC6 RAP1A RAP1B ZFYVE16 SCYL3 NBEA LAMP2 TFRC SCYL2 AP4E1 BNIP2 LNPEP SYNE2 VAMP7 SCFD1 PEAK1 LRBA GAB1 HTT	3.78e-06	659	172	19	int:STX7
Interaction	LAMP2 interactions	RAP1A MOSPD2 SLC11A2 KIF1A ZFYVE16 NBEA LAMP2 TFRC SCYL2 PIKFYVE LNPEP SYNE2 VAMP7 AP1M1 SCFD1 PEAK1 LRBA HTT	4.92e-06	609	172	18	int:LAMP2
Interaction	CALM1 interactions	CUL1 CASP8AP2 AMPH KIF1A LYST PDIA3 PHKG1 PPP3CC KCNB1 TBC1D1 SYNE2 SCN5A VAMP7 ASPM PEAK1 ATP2B2 ATP2B4 HTT	7.17e-06	626	172	18	int:CALM1
Interaction	STX6 interactions	ZFYVE16 SCYL3 NBEA LAMP2 TFRC SCYL2 AP4E1 LNPEP VAMP7 TRAPPC10 SCFD1 PEAK1 LRBA GAB1 HTT	7.30e-06	448	172	15	int:STX6
Interaction	KCNA3 interactions	TPR IPO7 MLEC ZFYVE16 SMC1A SPEF2 USP24 MTMR1 RNF213 LAMP2 AP3B1 TFRC SCYL2 ADSS2 SMC3 C1QC PEAK1 LRBA PLS3 GAB1 DOP1A	1.77e-05	871	172	21	int:KCNA3
Interaction	RAB25 interactions	RAP1B ZFYVE16 SYNE1 SCYL3 TFRC SCYL2 BNIP2 LNPEP PEAK1 LRBA FLOT1	1.80e-05	265	172	11	int:RAB25
Interaction	LAMP3 interactions	MOSPD2 SLC11A2 KIF1A ZFYVE16 RNF213 NBEA SLC1A3 TFRC SCYL2 PIKFYVE LNPEP SYNE2 VAMP7 SCFD1 LRBA	1.91e-05	486	172	15	int:LAMP3
Interaction	RAC3 interactions	RAP1B MOSPD2 SLC11A2 ZFYVE16 SCYL3 BRSK2 MTMR1 TFRC LNPEP GLUD2 VAMP7 SCFD1 PEAK1 LRBA FLOT1 GAB1 DOP1A	2.35e-05	619	172	17	int:RAC3
Interaction	BET1 interactions	ZFYVE16 SMC1A SCYL3 NBEA AKAP8L TFRC SCYL2 SMC3 LNPEP GLUD1 VAMP7 SCFD1 LRBA	2.78e-05	385	172	13	int:BET1
Interaction	NPTN interactions	EXOC6 USP24 RNF213 LCN2 MFN1 FOCAD PIKFYVE ATP2B2 ATP2B4 HTT DOP1A	2.80e-05	278	172	11	int:NPTN
Interaction	RHOB interactions	RAP1A RAP1B SLC11A2 ZFYVE16 FNTB BRSK2 UTP23 MTMR1 NBEA SLC1A3 TFRC SCYL2 LNPEP VAMP7 AKAP13 SCFD1 PEAK1 FLOT1 ATP2B4 GAB1	3.39e-05	840	172	20	int:RHOB
Interaction	GJA1 interactions	ZFYVE16 SCYL3 NBEA LAMP2 APOB TFRC SCYL2 AP4E1 LNPEP SYNE2 SCFD1 PEAK1 LRBA ATP2B4 GAB1 HTT	4.15e-05	583	172	16	int:GJA1
Interaction	TMEM17 interactions	MOSPD2 SCYL3 NBEA PIGU SLC1A3 TFRC SCYL2 AP4E1 LNPEP VAMP7 SCFD1 LRBA ATP2B4	4.56e-05	404	172	13	int:TMEM17
Interaction	RAC2 interactions	CUL1 RAP1B MOSPD2 SLC11A2 ZFYVE16 MTMR1 PIGU SLC1A3 TFRC LNPEP SYNE2 GLUD2 VAMP7 SCFD1 PEAK1 FLOT1 HTT	6.77e-05	674	172	17	int:RAC2
Interaction	RAB7A interactions	RAP1A RAP1B MOSPD2 MLEC KIF1A ZFYVE16 SCYL3 BRSK2 NBEA LAMP2 PIGU LYST TFRC PIKFYVE LNPEP SYNE2 VAMP7 SCFD1 LRBA FLOT1	7.11e-05	886	172	20	int:RAB7A
Interaction	H2AP interactions	RAP1A USP24 PSME2 PPP3CC LRBA HTT	7.25e-05	82	172	6	int:H2AP
Interaction	RAB5A interactions	TPR RAP1A RAP1B ZFYVE16 SCYL3 SLC1A3 TFRC SCYL2 PIKFYVE BNIP2 LNPEP SYNE2 VAMP7 SCFD1 PEAK1 LRBA HTT	1.19e-04	706	172	17	int:RAB5A
Interaction	ZFPL1 interactions	SCYL3 NBEA LAMP2 LCN2 TFRC SCYL2 AP4E1 LNPEP SCFD1 PEAK1 LRBA GAB1 FRMD3	1.29e-04	448	172	13	int:ZFPL1
Interaction	TDRD6 interactions	AP1M1 TDRD6 HTT	1.64e-04	13	172	3	int:TDRD6
Interaction	DNAJC25 interactions	MOSPD2 MLEC SYNE1 PIGU TFRC LNPEP SYNE2 NUP210 SCFD1 DNMT1	1.70e-04	284	172	10	int:DNAJC25
Cytoband	6q15	CASP8AP2 AKIRIN2 PNRC1 DOP1A	6.19e-06	31	177	4	6q15
Cytoband	Ensembl 112 genes in cytogenetic band chr6q15	CASP8AP2 AKIRIN2 RRAGD PNRC1	4.63e-05	51	177	4	chr6q15
GeneFamily	WD repeat domain containing\|BEACH domain containing	NBEA LYST LRBA	2.21e-05	9	118	3	1230
GeneFamily	Potassium sodium-activated channel subfamily T	KCNT2 KCNT1	4.22e-05	2	118	2	856
GeneFamily	SCY1 like pseudokinases	SCYL3 SCYL2	1.26e-04	3	118	2	1033
GeneFamily	Spectrin repeat containing nuclear envelope family	SYNE1 SYNE2	2.51e-04	4	118	2	1252
GeneFamily	Structural maintenance of chromosomes proteins\|Cohesin complex	SMC1A SMC3	8.68e-04	7	118	2	761
GeneFamily	Cohesin complex	SMC1A SMC3	1.15e-03	8	118	2	1060
GeneFamily	ATPases Ca2+ transporting	ATP2B2 ATP2B4	1.48e-03	9	118	2	1209
GeneFamily	Myotubularins\|Phosphoinositide phosphatases	MTMR12 MTMR1	4.20e-03	15	118	2	903
GeneFamily	Cadherin related	FAT3 FAT2	5.39e-03	17	118	2	24
GeneFamily	Zinc fingers\|Zinc fingers PARP-type\|Poly(ADP-ribose) polymerases	PARP14 PARP4	5.39e-03	17	118	2	684
GeneFamily	Ubiquitin specific peptidases	USP24 USP29 USP26	5.84e-03	56	118	3	366
Coexpression	MANNO_MIDBRAIN_NEUROTYPES_HRGL2A	CFAP47 SLC11A2 KIF1A FAT3 VEPH1 CCDC175 NBEA SLC1A3 FAT2 RRAGD GLUD1 MTTP DNAH6 ATP2B2 ATP2B4 HYDIN	3.19e-06	600	176	16	M39055
Coexpression	BUSSLINGER_GASTRIC_IMMUNE_CELLS	TPR RAP1A RAP1B AKIRIN1 SYNE1 SPEF2 USP24 RNF213 PSME2 PARP14 LYST PIKFYVE ARL4C PTPN6 PPP3CC SMC3 LNPEP TBC1D1 NUP210 TRAPPC10 AP1M1 PNRC1 AKAP13 LRBA ATP2B4 DNMT1	7.73e-06	1492	176	26	M40023
Coexpression	MANNO_MIDBRAIN_NEUROTYPES_HRGL2B	CENPN KIF1A FAT3 VEPH1 SLC1A3 FAT2 MTTP PEAK1 DNAH6 ATP2B2 ATP2B4 HYDIN GAB1	9.18e-06	439	176	13	M39054
Coexpression	NAKAYA_PLASMACYTOID_DENDRITIC_CELL_FLUMIST_AGE_18_50YO_7DY_UP	SLC11A2 IPO7 MLEC KIF1A SCYL3 MTMR1 LAMP2 KMO MFN1 SCYL2 ARL1 ZNF117 PPP3CC TBC1D1 SYNE2 NUP210 TRAPPC10 PYGB LRBA IKBKB FLOT1 COPS6	2.33e-05	1215	176	22	M41122
Coexpression	GSE39556_UNTREATED_VS_3H_POLYIC_INJ_MOUSE_NK_CELL_UP	SYNE1 MTMR1 AP3B1 KMO PTPN6 TBC1D1 SYNE2 NUP210	6.28e-05	199	176	8	M9410
Coexpression	GSE369_PRE_VS_POST_IL6_INJECTION_IFNG_WT_LIVER_DN	TPR RAP1A RAP1B KIF27 COL6A5 PIKFYVE ARL4C AP1M1	6.50e-05	200	176	8	M5980
Coexpression	GSE14769_UNSTIM_VS_360MIN_LPS_BMDM_DN	CUL1 TPR RBL1 KMO PIKFYVE SCN5A AKAP13 SLC16A10	6.50e-05	200	176	8	M3510
Coexpression	GSE15330_LYMPHOID_MULTIPOTENT_VS_PRO_BCELL_DN	FNTB RBL1 LYST ARL4C PARP4 ARL1 ADSS2 TBC1D1	6.50e-05	200	176	8	M7016
Coexpression	GSE32423_IL7_VS_IL7_IL4_NAIVE_CD8_TCELL_DN	RBL1 LYST PDIA3 PPP3CC ADSS2 RRAGD VAMP7 SCFD1	6.50e-05	200	176	8	M5096
Coexpression	GSE9006_HEALTHY_VS_TYPE_1_DIABETES_PBMC_4MONTH_POST_DX_UP	MTMR12 UAP1 AKIRIN1 PDIA3 BNIP2 RRAGD GLUD1 GLUD2	6.50e-05	200	176	8	M5779
Coexpression	GAO_ESOPHAGUS_25W_C1_CILIATED_EPITHELIAL_CELLS	CFAP47 KIF27 ASIC1 SYNE1 SPEF2 GAS8 USP24 NBEA CFAP43 KCNB1 DNAH6 HYDIN	6.81e-05	459	176	12	M39136
Coexpression	NUYTTEN_EZH2_TARGETS_UP	UAP1 ASIC1 SYNE1 SPEF2 LAMP2 AKIRIN2 PSME2 PARP14 LYST SLC1A3 KMO ARL4C PPP3CC ADSS2 KCNB1 LNPEP PNRC1 DDX60L FRMD5	7.09e-05	1033	176	19	M4196
Coexpression	OSMAN_BLADDER_CANCER_UP	ZFYVE16 THUMPD3 LYST PDIA3 PARP4 ADSS2 SMC3 LNPEP GLUD1 AKAP13 CRTAP	9.21e-05	402	176	11	M5275
ToppCell	3'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CFAP47 KIF27 SYNE1 SPEF2 CCDC175 CFAP43 AGBL4 KCNB1 SYNE2 DNAH6 HYDIN	4.44e-10	197	177	11	74a2c6cb8fcfe53dd9a2b36492a16c58f38e51c9
ToppCell	CV-Severe-7\|CV / Virus stimulation, Condition and Cluster	CYB5RL SLC11A2 TTLL5 MSANTD2 RNF213 PARP14 LYST MFN1 TFRC HTT	2.37e-09	176	177	10	3de0c7d77210049e5616db21eed1490a17a5ec2d
ToppCell	IPF-Multiplet-Multiplet\|IPF / Disease state, Lineage and Cell class	CFAP47 SYNE1 SPEF2 NBEA CFAP43 LCN2 AGBL4 SYNE2 DNAH6 HYDIN	6.36e-09	195	177	10	fce0c29574bb7aab181b9c00feb42681e285d1f2
ToppCell	IPF-Multiplet\|IPF / Disease state, Lineage and Cell class	CFAP47 SYNE1 SPEF2 NBEA CFAP43 LCN2 AGBL4 SYNE2 DNAH6 HYDIN	6.36e-09	195	177	10	eacc0449ae6f3ad8002268cd061467684c6fb9a7
ToppCell	CV-Severe-7\|Severe / Virus stimulation, Condition and Cluster	CYB5RL SLC11A2 TTLL5 MSANTD2 RNF213 LYST MFN1 TFRC HTT	3.99e-08	177	177	9	82fdd6185b368f54f03de389427cbe3071d21a99
ToppCell	droplet-Limb_Muscle-MUSCLE-30m\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TPR CASP8AP2 MOSPD2 SYNE1 SMC1A PARP14 LYST SMC3 SYNE2	4.19e-08	178	177	9	01dafd19de04eff459253eaa9a35debf8f3deedf
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.3.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CFAP47 KIF27 SYNE1 SPEF2 NBEA CFAP43 AGBL4 DNAH6 HYDIN	8.76e-08	194	177	9	4a2c127c90d1fefe604fcb9e796577d21b489dd6
ToppCell	severe\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	RAP1B PSMD7 PDIA3 ARL4C BNIP2 SYNE2 TRAPPC10 PNRC1 FLOT1	1.14e-07	200	177	9	accc618d6b960bff30cb531c1226295bfc8650f6
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic-precursor_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL12A1 ABCA12 FAT3 COL6A5 ALX4 KCNT2 TDRD6 HYDIN	2.63e-07	160	177	8	c381ec6be8cf887861cc18f831a20db42f953fe1
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic-pre_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL12A1 ABCA12 FAT3 COL6A5 ALX4 KCNT2 TDRD6 HYDIN	2.63e-07	160	177	8	25c8f3d2a6d14ff0ca0b965fce89d3ff22f40585
ToppCell	CD8+_Memory_T_cell-CV-7\|CD8+_Memory_T_cell / cell class, Virus stimulation and cluster	RNF213 LAMP2 PARP14 LYST PDIA3 TFRC LNPEP LRBA	1.01e-06	191	177	8	9454f642c3621370fa23640b631301346b300950
ToppCell	facs-Skin-Telogen-3m-Epithelial\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	UAP1 RAP1B LAMP2 PDIA3 LNPEP SYNE2 GLUD1 PLS3	1.13e-06	194	177	8	4d7fc4d0a55abb3b645116d13a983bbedc55f70c
ToppCell	facs-Skin-Telogen-3m\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	UAP1 RAP1B LAMP2 PDIA3 LNPEP SYNE2 GLUD1 PLS3	1.13e-06	194	177	8	ba10fc5929649bb994c3f1d2ce6ca3167fa9b11b
ToppCell	facs-Skin-Telogen\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	UAP1 RAP1B LAMP2 PDIA3 LNPEP SYNE2 GLUD1 PLS3	1.13e-06	194	177	8	bafecab8d48fc94ffd93f0d054b5f32c04b6b3f6
ToppCell	IPF-Multiplet-Multiplet\|World / Disease state, Lineage and Cell class	CFAP47 SPEF2 CFAP43 LCN2 AGBL4 SYNE2 DNAH6 HYDIN	1.17e-06	195	177	8	21dbdc803c6947024dc2416e9e21c2ef0af9bc31
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	AMPH SYNE1 NBEA FOCAD AGBL4 KCNB1 PKD1 ATP2B2	1.22e-06	196	177	8	676c56b44ac29f7baecb62f49bb8597cc74c0a88
ToppCell	COPD-Multiplet-Multiplet\|COPD / Disease state, Lineage and Cell class	CFAP47 SYNE1 CFAP43 AGBL4 SYNE2 ASPM DNAH6 HYDIN	1.22e-06	196	177	8	af4cdc61830685a888a1209826c23bcf54a43084
ToppCell	COPD-Multiplet\|COPD / Disease state, Lineage and Cell class	CFAP47 SYNE1 CFAP43 AGBL4 SYNE2 ASPM DNAH6 HYDIN	1.22e-06	196	177	8	6d02d494196e3f857d53eea46d9419690d43beca
ToppCell	Somatosensory_Cortex_(S1)-Neuronal\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	AMPH SYNE1 NBEA FOCAD AGBL4 KCNB1 PKD1 ATP2B2	1.32e-06	198	177	8	c01091ef18e096d792ea2a7a715764a5b215355f
ToppCell	COVID-19-COVID-19_Mild-Lymphocyte-T/NK-dn_T\|COVID-19_Mild / Disease, condition lineage and cell class	UAP1 USP24 LYST ARL4C PARP4 SYNE2 LRBA ATP2B4	1.37e-06	199	177	8	f307d4887b28cf60a591439e278fd668409cb104
ToppCell	Neuronal\|World / cells hierarchy compared to all cells using T-Statistic	AMPH SYNE1 NBEA FOCAD AGBL4 KCNB1 PKD1 ATP2B2	1.42e-06	200	177	8	48d801219bc771d6c7e151dc88ca4c179988de85
ToppCell	VE\|World / Condition, Cell_class and T cell subcluster	RNF213 PSME2 PARP14 ARL4C LNPEP SYNE2 PNRC1 AKAP13	1.42e-06	200	177	8	8ae7cb81de3ffac5acdf3466d4b516d80cac95d3
ToppCell	mild-NK\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	RAP1B SYNE1 RNF213 ARL4C LNPEP SYNE2 TRAPPC10 ATP2B4	1.42e-06	200	177	8	a11fb1d7e124c352eb73fea0e0ec0fed577c97f7
ToppCell	COVID-19-COVID-19_Mild-Lymphocyte-T/NK-NK_activated\|COVID-19_Mild / Disease, condition lineage and cell class	SYNE1 USP24 RNF213 ARL4C LNPEP SYNE2 PEAK1 ATP2B4	1.42e-06	200	177	8	2281debd86e5d92e8fe0397aec9ef670800f7471
ToppCell	5'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.2\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CFAP47 SPEF2 CCDC175 CFAP43 AGBL4 DNAH6 HYDIN	5.22e-06	169	177	7	fba841664939c771881ba97f14ef1df6635c04ff
ToppCell	facs-Diaphragm-Limb_Muscle-24m\|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ABCA12 FAT3 VEPH1 LCN2 DNAH6 ATP2B2 HYDIN	5.22e-06	169	177	7	12bdc709bc000d7f9061ecd9fbd57233eaacb7e2
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_5-Exc_L4-5_RORB_HNRNPA1P46\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	LRRK1 PARP4 KCNT2 FMN1 AFP SCN5A DNAH6	7.89e-06	180	177	7	8923a42a6db9c6e9f3ce2ca9530e620dfea700ba
ToppCell	Adult-Epithelial-ciliated_cell-D175\|Adult / Lineage, Cell type, age group and donor	CFAP47 SPEF2 CCDC175 CFAP43 AGBL4 DNAH6 HYDIN	9.43e-06	185	177	7	30f4980dee6cd5959655f8d74049f3bfb5312611
ToppCell	COVID-19-lung-Ciliated\|lung / Disease (COVID-19 only), tissue and cell type	CFAP47 SPEF2 CCDC175 CFAP43 AGBL4 DNAH6 HYDIN	1.08e-05	189	177	7	27329c4661aebabd19fac7fe5dca263fe99d76f3
ToppCell	10x3'2.3-week_17-19-Lymphocytic_B-B_lineage-naive_B_cell\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	PARP14 KMO TLR10 ARL4C PTPN6 TRAPPC10 AKAP13	1.16e-05	191	177	7	a073d58154c801ec499fd969f42b7f1ee7f15d79
ToppCell	IPF-Epithelial-Ciliated\|Epithelial / Disease state, Lineage and Cell class	CFAP47 SYNE1 SPEF2 CFAP43 AGBL4 DNAH6 HYDIN	1.24e-05	193	177	7	ad58f5080e0ba65c845056ea6b79037b636e9c64
ToppCell	3'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.3\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CFAP47 SYNE1 SPEF2 CFAP43 KCNB1 DNAH6 HYDIN	1.24e-05	193	177	7	bdb7401dd9059032f930f2b575f2ef8e504b6594
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Immune-Myeloid-Macrophage_Dendritic-M2_Macrophage\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	SLC11A2 SLC1A3 PIK3R6 FMN1 C1QC PEAK1 SLC16A10	1.28e-05	194	177	7	45708cb2cafde10bf4e4798b81d47c3b1f6aaa14
ToppCell	COVID-19_Mild-PLT_5\|COVID-19_Mild / Disease Group and Platelet Clusters	MTMR1 RNF213 ARL4C FMN1 SYNE2 DDX60L ATP2B4	1.33e-05	195	177	7	bdf9a6ea1bd83c72a834c45f86ce3f4643a9bef3
ToppCell	10x5'-Liver-Lymphocytic_NK-NK_CD16\|Liver / Manually curated celltypes from each tissue	UAP1 RAP1B SYNE1 GPR141 ARL4C PPP3CC SYNE2	1.37e-05	196	177	7	e6d4853ccefbcd45a019cee595811f0474dcc036
ToppCell	mild-low-quality_cells\|mild / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	PLXNA3 SYNE1 SPEF2 ALDH8A1 RNF213 SYNE2 LRBA	1.42e-05	197	177	7	e4331969bd911d1ebb5453f40a7057297b5389b4
ToppCell	ASK440-Epithelial-Type_1\|Epithelial / Donor, Lineage and Cell class of Lung cells from Dropseq	COL12A1 PARP14 ARL4C KCNT2 PEAK1 ATP2B4 PLS3	1.42e-05	197	177	7	782449c522c9e16e72bf999a73090688a3aefe06
ToppCell	Control-Control-Lymphocyte-T/NK-NK_activated\|Control / Disease, condition lineage and cell class	SYNE1 RNF213 ARL4C LNPEP SYNE2 ATP2B4 FRMD5	1.46e-05	198	177	7	76d5fe4e5bbe6c73a6ca409b80b5c3924e07cab7
ToppCell	NS-critical-LOC\|critical / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	ZFYVE16 RNF213 AKIRIN2 PARP14 PNRC1 DDX60L FLOT1	1.46e-05	198	177	7	ff9b9065f5d91a7aff99121bddc3e86f6b1c8a8d
ToppCell	primary_auditory_cortex_(A1C)-Neuronal\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	AMPH SYNE1 NBEA FOCAD AGBL4 KCNB1 ATP2B2	1.46e-05	198	177	7	6d18b45eda4014759e6dd282d78ffd28df8a6044
ToppCell	CV\|World / Virus stimulation, Condition and Cluster	RAP1B SYNE1 RNF213 PSME2 ARL4C SYNE2 ATP2B4	1.46e-05	198	177	7	6a28193af35abec5c029129930c2ca6febaafde2
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	AMPH SYNE1 NBEA FOCAD AGBL4 NETO1 ATP2B2	1.46e-05	198	177	7	4ca5ff320905ab4ff60ed90a5522227c782142a6
ToppCell	CD8+_Memory_T_cell-CV\|CD8+_Memory_T_cell / cell class, Virus stimulation and cluster	RAP1B SYNE1 RNF213 PSME2 ARL4C SYNE2 ATP2B4	1.46e-05	198	177	7	3d1749f5106f0912f4a74615863853949f52c73d
ToppCell	Bronchial-NucSeq-Immune_Myeloid-Macrophage_alveolar-Macro_alv_MT\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	SLC1A3 KMO TFRC USP26 FMN1 C1QC SLC16A10	1.51e-05	199	177	7	951c2ea5af4756832c2adcec3ee70a7e36331a4e
ToppCell	343B-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_4\|CD8+_Cytotoxic_T-cell / Donor, Lineage, Cell class and subclass (all cells)	PSME2 PNRC1	1.54e-05	2	177	2	f979692da408f4de39d8037f449b983dfd99fc6d
ToppCell	Neuronal-Excitatory-eG(DAPK2)-\|Neuronal / cells hierarchy compared to all cells using T-Statistic	LRRK1 PARP4 KCNT2 FMN1 AFP SCN5A DNAH6	1.56e-05	200	177	7	7cea58e2691564e653cc972bf5aaff2df1f2666e
ToppCell	Neuronal-Excitatory-eG(DAPK2)--\|Neuronal / cells hierarchy compared to all cells using T-Statistic	LRRK1 PARP4 KCNT2 FMN1 AFP SCN5A DNAH6	1.56e-05	200	177	7	193c42c31a366a60d80c4c1fc6a1592a5b01a3ad
ToppCell	Neuronal-Excitatory-eG(DAPK2)---\|Neuronal / cells hierarchy compared to all cells using T-Statistic	LRRK1 PARP4 KCNT2 FMN1 AFP SCN5A DNAH6	1.56e-05	200	177	7	7c780e995a5fc3793080da61b6bf7a12880e9df8
ToppCell	Neuronal-Excitatory-eG(DAPK2)----L4-5\|Neuronal / cells hierarchy compared to all cells using T-Statistic	LRRK1 PARP4 KCNT2 FMN1 AFP SCN5A DNAH6	1.56e-05	200	177	7	d0b31dc5eedc0635c0d7ceabaa6202386cf2a4a4
ToppCell	severe-gd_T\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	RAP1B SYNE1 RNF213 PDIA3 ARL4C SYNE2 TRAPPC10	1.56e-05	200	177	7	2253d74049cc49c92e897ff4aa298d913daeb739
ToppCell	Neuronal-Excitatory-eG(DAPK2)\|Neuronal / cells hierarchy compared to all cells using T-Statistic	LRRK1 PARP4 KCNT2 FMN1 AFP SCN5A DNAH6	1.56e-05	200	177	7	8444ae3c10b1152dec67ca812e6c417cc3b9cf89
ToppCell	Non-neuronal-Dividing-IPC-IPC-div2\|World / Primary Cells by Cluster	CENPN SMC1A SLC1A3 SMC3 SYNE2 ASPM DNMT1	1.56e-05	200	177	7	4923d7a4f00853c4d76fc1cc0fa82d522a2302e7
ToppCell	Non-neuronal-Dividing-IPC-IPC-div2-5\|World / Primary Cells by Cluster	CENPN SMC1A SLC1A3 SMC3 SYNE2 ASPM DNMT1	1.56e-05	200	177	7	dc1c1506823eaa105f1532c6b5d4efa14e788314
ToppCell	severe-CD8+_Tem\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	RAP1B SYNE1 RNF213 PDIA3 ARL4C SYNE2 PNRC1	1.56e-05	200	177	7	6aa77955017d073a96324e4db6b9950a2ec46cf8
ToppCell	severe-NK\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	RAP1B SYNE1 RNF213 PDIA3 ARL4C SYNE2 TRAPPC10	1.56e-05	200	177	7	d6767f06fe13be8110a86c2a6029be2dd9ce666c
ToppCell	COVID-19-Epithelial_cells-Airway_mucous\|COVID-19 / group, cell type (main and fine annotations)	CFAP47 SPEF2 CFAP43 AGBL4 DNAH6 HYDIN	3.16e-05	151	177	6	8216462e723fec2797387929dde095370947e10a
ToppCell	Leuk-UTI-Lymphocyte-T_NK-CD4_CTL\|Leuk-UTI / Disease, Lineage and Cell Type	AMPH RAP1B BRSK2 ARL4C SYNE2 HYDIN	3.53e-05	154	177	6	170a421fd69dba2929568c72e983ae9cfaf2aabc
ToppCell	NS-moderate-d_07-13-Epithelial-FOXN4+\|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	CFAP47 KIF27 SPEF2 CCDC171 DNAH6 HYDIN	3.93e-05	157	177	6	410c9d74a2085179cfb39853cb6d330fa98c9c1b
ToppCell	facs-Pancreas-Exocrine-18m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZFYVE16 USP24 KCTD4 AP4E1 GCNT7 FMN1	4.85e-05	163	177	6	132aece9c79499b4bb3c2bde68d3d7202e1d8772
ToppCell	Ciliated_cells-B-Donor_03\|World / lung cells shred on cell class, cell subclass, sample id	CFAP47 KIF1A SPEF2 CCDC175 CFAP43 HYDIN	5.02e-05	164	177	6	fd30c55d0d75ef8b9396435d836187168095152b
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c03-GZMK\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	SYNE1 ARL4C ERICH6B SYNE2 ASPM ATP2B4	5.55e-05	167	177	6	abc4ba308ca3be41b0da604f5d82579fd58dff7b
ToppCell	3'_v3-lymph-node_spleen-Lymphocytic_T_CD4-T_CD4/CD8\|lymph-node_spleen / Manually curated celltypes from each tissue	SYNE1 RNF213 APOB TFRC ARL4C SYNE2	6.33e-05	171	177	6	2e9a20f8980b78325c52065a9c14ab3656267c05
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_2-Exc_L3-4_RORB_PRSS12\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	COL12A1 LRRK1 FMN1 METTL21C GAB1 KCNH5	6.97e-05	174	177	6	ae363ce736fc8af439f3ad594d7bc2e344db80d4
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_5-Exc_L4-5_RORB_HNRNPA1P46\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	LRRK1 KCNT2 FMN1 SCN5A ASPM DNAH6	8.15e-05	179	177	6	c815eb9f760fe4ca7a5e49beb224659f0b864f22
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_5-Exc_L4-5_RORB_HNRNPA1P46\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	LRRK1 KCNT2 FMN1 AFP SCN5A DNAH6	8.15e-05	179	177	6	53e700494d251ec5649b2dea5fc7d5aeeeed572b
ToppCell	Control-Myeloid-DC1\|Control / Condition, Lineage and Cell class	GPR141 LRRK1 TLR10 FSIP2 ARL4C PIK3R6	8.66e-05	181	177	6	5a2a1f017ad23baed9972c68b4a46f4c618ef21a
ToppCell	TCGA-Skin-Metastatic-Melanoma-Skin_Cutaneous_Melanoma-2\|TCGA-Skin / Sample_Type by Project: Shred V9	CYB5RL LAMP2 LYST RRAGD FMN1 LRBA	8.66e-05	181	177	6	9d5b331cabc5524f0a9fd8b571e87be4c447c7d4
ToppCell	Hippocampus-Neuronal-Excitatory-eN1(Slc17a7)-eN1_1-Fibcd1-Excitatory_Neuron.Slc17a7.Fibcd1-Nrip3_(CA1_Principal_cells)\|Hippocampus / BrainAtlas - Mouse McCarroll V32	ALDH8A1 AGXT2 PDIA2 KRT36	8.90e-05	59	177	4	172f1c6fdc8005a6f21d68a4dc0f8631c265d9e5
ToppCell	Adult-Epithelial-ciliated_cell-D122\|Adult / Lineage, Cell type, age group and donor	CFAP47 SPEF2 CFAP43 AGBL4 DNAH6 HYDIN	8.93e-05	182	177	6	7ded554a4b441e6496db673ba206c0d76ccad7d9
ToppCell	Control-Epithelial_cells-Airway_ciliated\|Control / group, cell type (main and fine annotations)	CFAP47 SPEF2 CFAP43 AGBL4 DNAH6 HYDIN	8.93e-05	182	177	6	fb725d10d9ed25dfc6d5bb69cfef78513f7d3e8f
ToppCell	droplet-Marrow-nan-3m-Hematologic-nan\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TPR CASP8AP2 LYST ARL4C PNRC1 PEAK1	8.93e-05	182	177	6	e78ba2c5cae480c16a596ce7c3bf2d480becacf4
ToppCell	wk_15-18-Epithelial-Proximal_epithelial-Deuterosomal\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	CFAP47 GAS8 CFAP43 AGBL4 DNAH6 HYDIN	8.93e-05	182	177	6	000eca5baa6eb2335a1e6d76a13fff5382b0e150
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Principal_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	VEPH1 AGBL4 SLC9A2 CCDC42 PLS3 SLC16A10	8.93e-05	182	177	6	f96095b81188b52db8fcfca4837129cfcd9bd7b7
ToppCell	IPF-Myeloid-DC_Langerhans\|World / Disease state, Lineage and Cell class	MTMR12 TRPC6 GPR141 LRRK1 TLR10 PIK3R6	8.93e-05	182	177	6	0e8cfbd8ea196f27a227dbb4d2eb93bc48d27922
ToppCell	droplet-Marrow-nan-3m-Hematologic\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TPR CASP8AP2 LYST ARL4C PNRC1 PEAK1	8.93e-05	182	177	6	1710eab3037a87609d21838be2d2d29c3bc36651
ToppCell	3'_v3-lymph-node_spleen-Hematopoietic_progenitors-Progenitor_pre-Lymphocytic-T\|lymph-node_spleen / Manually curated celltypes from each tissue	MOSPD2 TTLL5 CCDC175 PIGU RRAGD FRMD3	9.20e-05	183	177	6	6c55fd737ed31f5b1aa41dc4dba7240521c19022
ToppCell	droplet-Lung-immune-endo-depleted-3m-Myeloid-Proliferating_Alveolar_Macrophage\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CENPN RBL1 NETO1 AFP ASPM SLC16A10	9.20e-05	183	177	6	42dc31d587fbb9724b2f0be5ee8ed77233f67b86
ToppCell	TCGA-Thryoid-Primary_Tumor-Thyroid_Papillary_Carcinoma-Classical-4\|TCGA-Thryoid / Sample_Type by Project: Shred V9	IPO7 LCN2 LYST ADSS2 PYGB FRMD5	9.48e-05	184	177	6	d9659d1e4465fec68f48a22edef443f354f6c7cf
ToppCell	LPS_only-Unknown-Endothelial\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PDE6A MATN1 TRPC6 KCNT2 KCNH5	9.63e-05	115	177	5	ad5298c2ad8bf94fa13c2e50b0799e929473ef59
ToppCell	LPS_only-Unknown\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PDE6A MATN1 TRPC6 KCNT2 KCNH5	9.63e-05	115	177	5	7a733f6987b40ec497a03734b79ed5355ad3a2fc
ToppCell	LPS_only-Unknown-Endothelial-Pericyte_2\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PDE6A MATN1 TRPC6 KCNT2 KCNH5	9.63e-05	115	177	5	c67145d3cd9243994a141749b426ff2a6dcc8d93
ToppCell	IPF-Myeloid-DC_Langerhans\|IPF / Disease state, Lineage and Cell class	MTMR12 TRPC6 GPR141 LRRK1 TLR10 PIK3R6	9.76e-05	185	177	6	f8ee3cb2aa9ec70f9ce8797be2b155da27ef6464
ToppCell	normal-na-Lymphocytic_NK-NK_dim-male\|normal / PBMC cell types (v2) per disease, treatment status, and sex	RAP1B SYNE1 RNF213 PDIA3 ARL4C SYNE2	9.76e-05	185	177	6	b1a8a8c4d0fc7605eabc17dcb6bd9e8ab4fd578c
ToppCell	COVID-19-Epithelial_cells-Airway_ciliated\|COVID-19 / group, cell type (main and fine annotations)	CFAP47 SPEF2 CFAP43 AGBL4 DNAH6 HYDIN	9.76e-05	185	177	6	18a40f0a338aa398d81384b5159fb80ce8a2020c
ToppCell	Smart-seq2-spleen_(Smart-seq2)-lymphocytic-innate_lymphocytic\|spleen_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	RAP1B SYNE1 GPR141 ARL4C LNPEP ATP2B4	1.01e-04	186	177	6	fc0b488c201a32d829047b58460297df2818b45d
ToppCell	PND03\|World / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	RAP1B SPEF2 CFAP43 LCN2 LYST AKAP13	1.04e-04	187	177	6	b3fcb36d853adfdea7172c5591de06f027e50af3
ToppCell	systemic_lupus_erythematosus-flare-Lymphocytic_NK-NK_dim-male\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	RAP1B SYNE1 RNF213 PDIA3 ARL4C SYNE2	1.04e-04	187	177	6	0bca79cea4886b66350c56c61859bd71e1e7a85c
ToppCell	Smart-seq2-spleen_(Smart-seq2)-lymphocytic-innate_lymphocytic-mature_NK_T_cell\|spleen_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	SYNE1 GPR141 ARL4C LNPEP SYNE2 ATP2B4	1.04e-04	187	177	6	6981b856187a2e689260ecb7d0a1193a374ee9b9
ToppCell	10x5'-GI_small-bowel-Lymphocytic_T_CD4-T_CD4/CD8\|GI_small-bowel / Manually curated celltypes from each tissue	USP24 RNF213 PARP14 LNPEP SYNE2 LRBA	1.07e-04	188	177	6	ab9b725d6e0cdab8e9ddda6dee09e14730e9a578
ToppCell	Epithelial-ciliated_cell\|World / Lineage, Cell type, age group and donor	CFAP47 SPEF2 CFAP43 AGBL4 DNAH6 HYDIN	1.07e-04	188	177	6	61a459f3fe57e5728efc72637ff2edc2d343492b
ToppCell	Epithelial-Epithelial-D_(Ciliated)\|Epithelial / shred on cell class and cell subclass (v4)	KIF27 SYNE1 SPEF2 CFAP43 DNAH6 HYDIN	1.07e-04	188	177	6	8f30535a32968a81a304315a49c0d90a77d36948
ToppCell	Adult-Epithelial-ciliated_cell-D231\|Adult / Lineage, Cell type, age group and donor	CFAP47 SPEF2 CFAP43 AGBL4 DNAH6 HYDIN	1.07e-04	188	177	6	34b11f72ca73153d02edcd09b38983ad1a504659
ToppCell	Children_(3_yrs)-Epithelial-ciliated_cell\|Children_(3_yrs) / Lineage, Cell type, age group and donor	CFAP47 SPEF2 CFAP43 AGBL4 DNAH6 HYDIN	1.07e-04	188	177	6	2b6dfc88be9ded7b88da9fe78a9cd9f9b3af8af3
ToppCell	COVID-19-lung-Ciliated\|COVID-19 / Disease (COVID-19 only), tissue and cell type	CFAP47 SPEF2 CCDC175 CFAP43 DNAH6 HYDIN	1.10e-04	189	177	6	a2da5debd10f27b1280b40141ef0bfef007cc72c
ToppCell	Children_(3_yrs)-Epithelial-ciliated_cell-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	CFAP47 SPEF2 CFAP43 AGBL4 DNAH6 HYDIN	1.10e-04	189	177	6	68a3cf7763d6f9b95d6d6524eff7a16042703f1d
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	FAT3 CFAP43 PARP4 SYNE2 DNAH6 HYDIN	1.10e-04	189	177	6	904b8337e2cabac2f0bf5dad5598fc429581ed81
ToppCell	Adult-Epithelial-ciliated_cell\|Adult / Lineage, Cell type, age group and donor	CFAP47 SPEF2 CFAP43 AGBL4 DNAH6 HYDIN	1.10e-04	189	177	6	b679920f0993e917dd86da082113bfbd85ea1ca5
ToppCell	COPD-Epithelial-Ciliated\|Epithelial / Disease state, Lineage and Cell class	CFAP47 SPEF2 CFAP43 AGBL4 DNAH6 HYDIN	1.10e-04	189	177	6	3e77883db34722b9ce0a03ea74caefc92dc7feff
ToppCell	droplet-Large_Intestine-COLON_PROXIMAL-30m-Epithelial-Lgr5-_amplifying_undifferentiated_cell\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TPR MLEC TFRC NDUFAF4 SMC3 GLUD1	1.13e-04	190	177	6	36e83995021ba16690f84e2077a9e8baec547d05
ToppCell	5'-Parenchyma_lung-Immune_Lymphocytic-Lymphocytic_T/NK-CD8-positive,_alpha-beta_T_cell-CD8_T_cells-CD8_T_cells_L.1.1.4.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SYNE1 GPR141 RNF213 PPP3CC LNPEP SYNE2	1.13e-04	190	177	6	d153a0bdedcd6865e6ee19575234a78b5d859ff1
Drug	AC1NST48	KIF1A RBL1 GAS8 NBEA LAMP2 APOB PSME2 AP3B1 LYST TFRC SCYL2 AP4E1 ARL1 LNPEP MTTP LRBA FLOT1 PLS3	8.14e-07	594	175	18	CID005315496
Drug	bathophenanthroline disulfonic acid	SLC11A2 LCN2 TFRC	4.41e-06	5	175	3	ctd:C017049
Drug	Advicor	APOB NETO1 SYNE2	4.41e-06	5	175	3	CID000151176
Drug	isodiazinon	KMO GLUD1 GLUD2	8.78e-06	6	175	3	CID000133913
Drug	1,4-bis-(phenoxyacetyl)piperazine	CUL1 ZFYVE16 NBEA LAMP2 AP3B1 LYST TFRC SCYL2 VAMP7 AP1M1	1.00e-05	225	175	10	CID001008511
Drug	etofylline	TTLL5 APOB TBC1D1	1.53e-05	7	175	3	CID000001892
Disease	neurodevelopmental disorder with eye movement abnormalities and ataxia (implicated_via_orthology)	FRMD5 FRMD3	3.38e-05	2	172	2	DOID:0081275 (implicated_via_orthology)
Disease	urate measurement, bone density	CASP8AP2 CYP2C8 SYNE1 TRPC6 COL6A5 SCYL2 FSIP2 SCFD1 PEAK1 ATP2B2 ATP2B4 CRTAP KCNH5	7.47e-05	619	172	13	EFO_0003923, EFO_0004531
Disease	fascioliasis (biomarker_via_orthology)	GLUD1 GLUD2	1.01e-04	3	172	2	DOID:885 (biomarker_via_orthology)
Disease	duodenal ulcer (biomarker_via_orthology)	SLC11A2 TFRC	1.01e-04	3	172	2	DOID:1724 (biomarker_via_orthology)
Disease	Kabuki make-up syndrome	RAP1A RAP1B	2.01e-04	4	172	2	C0796004
Disease	Autosomal dominant Emery-Dreifuss muscular dystrophy	SYNE1 SYNE2	2.01e-04	4	172	2	cv:CN293514
Disease	Iron deficiency anemia	SLC11A2 TFRC	2.01e-04	4	172	2	C0162316
Disease	hereditary sensory neuropathy (is_implicated_in)	KIF1A DNMT1	2.01e-04	4	172	2	DOID:0050548 (is_implicated_in)
Disease	Autosomal Recessive Emery-Dreifuss Muscular Dystrophy	SYNE1 SYNE2	3.34e-04	5	172	2	C1450051
Disease	Autosomal Dominant Emery-Dreifuss Muscular Dystrophy (disorder)	SYNE1 SYNE2	3.34e-04	5	172	2	C0410190
Disease	Congenital muscular hypertrophy-cerebral syndrome	SMC1A SMC3	3.34e-04	5	172	2	C1802395
Disease	Cornelia de Lange Syndrome 3	SMC1A SMC3	3.34e-04	5	172	2	C1853099
Disease	Cornelia de Lange Syndrome 1	SMC1A SMC3	3.34e-04	5	172	2	C4551851
Disease	Epilepsy	SMC1A SLC1A3 KCNT2 GLUD1 KCNH5	4.55e-04	109	172	5	C0014544
Disease	Emery-Dreifuss muscular dystrophy	SYNE1 SYNE2	4.99e-04	6	172	2	cv:C0410189
Disease	De Lange syndrome	SMC1A SMC3	4.99e-04	6	172	2	cv:C0270972
Disease	Muscular Dystrophy, Emery-Dreifuss	SYNE1 SYNE2	4.99e-04	6	172	2	C0410189
Disease	Hailey-Hailey disease (implicated_via_orthology)	ATP2B2 ATP2B4	4.99e-04	6	172	2	DOID:0050429 (implicated_via_orthology)
Disease	childhood absence epilepsy (biomarker_via_orthology)	GLUD1 GLUD2	4.99e-04	6	172	2	DOID:1825 (biomarker_via_orthology)
Disease	Cornelia de Lange syndrome (implicated_via_orthology)	SMC1A SMC3	4.99e-04	6	172	2	DOID:11725 (implicated_via_orthology)
Disease	heroin dependence	BRSK2 CCDC42	6.96e-04	7	172	2	EFO_0004240
Disease	X-Linked Emery-Dreifuss Muscular Dystrophy	SYNE1 SYNE2	6.96e-04	7	172	2	C0751337
Disease	cysteine-rich with EGF-like domain protein 1 measurement	NUP210 ATP2B2 ATP2B4	8.53e-04	32	172	3	EFO_0021870
Disease	Cornelia De Lange Syndrome	SMC1A SMC3	9.24e-04	8	172	2	C0270972
Disease	clopidogrel metabolite measurement	CYP2C19 ATP2B2 ATP2B4	9.34e-04	33	172	3	EFO_0007966
Disease	Kartagener Syndrome	SPEF2 GAS8 HYDIN	1.11e-03	35	172	3	C0022521
Disease	Ciliary Dyskinesia, Primary, 1, With Or Without Situs Inversus	SPEF2 GAS8 HYDIN	1.11e-03	35	172	3	C4551906
Disease	Polynesian Bronchiectasis	SPEF2 GAS8 HYDIN	1.11e-03	35	172	3	C4317124
Disease	opportunistic bacterial infectious disease (implicated_via_orthology)	AKIRIN1 AKIRIN2	1.18e-03	9	172	2	DOID:0050340 (implicated_via_orthology)
Disease	bipolar I disorder	SYNE1 KCNB1 MAD1L1 ATP2B2 ATP2B4	1.45e-03	141	172	5	EFO_0009963
Disease	familial hypercholesterolemia (is_implicated_in)	APOB MTTP	1.47e-03	10	172	2	DOID:13810 (is_implicated_in)
Disease	pneumonia (implicated_via_orthology)	SLC11A2 IKBKB	1.47e-03	10	172	2	DOID:552 (implicated_via_orthology)
Disease	lipoprotein-associated phospholipase A(2) measurement	RNF213 APOB FRMD5	1.64e-03	40	172	3	EFO_0004746
Disease	type 2 diabetes mellitus (biomarker_via_orthology)	CYP2C19 CYP2C8 SMC1A TRPC6 DNMT1	1.74e-03	147	172	5	DOID:9352 (biomarker_via_orthology)
Disease	complement factor H measurement	TFRC FBXO38 KCNT2	1.76e-03	41	172	3	EFO_0008097
Disease	cytochrome p450 3a4 measurement	APOB PIKFYVE	1.79e-03	11	172	2	EFO_0020303
Disease	autosomal dominant nonsyndromic deafness (is_implicated_in)	THOC1 ATP2B2	1.79e-03	11	172	2	DOID:0050564 (is_implicated_in)
Disease	Cooley's anemia	LCN2 TFRC	2.15e-03	12	172	2	C0002875
Disease	Thalassemia Intermedia	LCN2 TFRC	2.15e-03	12	172	2	C0271979
Disease	Emery-Dreifuss muscular dystrophy (implicated_via_orthology)	SYNE1 SYNE2	2.15e-03	12	172	2	DOID:11726 (implicated_via_orthology)
Disease	hyperinsulinism (is_implicated_in)	GLUD1 MTTP	2.15e-03	12	172	2	DOID:2018 (is_implicated_in)
Disease	Thalassemia Minor	LCN2 TFRC	2.15e-03	12	172	2	C0085578
Disease	beta Thalassemia	LCN2 TFRC	2.15e-03	12	172	2	C0005283
Disease	schizophrenia (is_marker_for)	KMO PPP3CC DNMT1	2.16e-03	44	172	3	DOID:5419 (is_marker_for)
Disease	amino acid measurement	ZFYVE16 ABCA12 SYNE1 LRRK1 ALX4 CCDC42 FMN1 GLUD1 OR2D2 LRBA HTT	2.19e-03	678	172	11	EFO_0005134
Disease	S-warfarin measurement	EXOC6 CYP2C19 FMN1 TBC1D1	2.53e-03	97	172	4	EFO_0803323
Disease	Primary Ciliary Dyskinesia	SPEF2 GAS8 HYDIN	2.61e-03	47	172	3	C4551720
Disease	epilepsy (implicated_via_orthology)	SLC1A3 KCNT2 SCN5A KCNT1 KCNH5	2.73e-03	163	172	5	DOID:1826 (implicated_via_orthology)
Disease	complement factor H-related protein 4 measurement	KIF1A KCNT2 ASPM	2.95e-03	49	172	3	EFO_0600091
Disease	brain ischemia (biomarker_via_orthology)	SLC11A2 GLUD1 GLUD2 SCN5A	3.04e-03	102	172	4	DOID:2316 (biomarker_via_orthology)
Disease	Down syndrome (implicated_via_orthology)	RCAN3 DOP1A	3.37e-03	15	172	2	DOID:14250 (implicated_via_orthology)
Disease	platelet storage pool deficiency (implicated_via_orthology)	AP3B1 LYST	3.37e-03	15	172	2	DOID:2223 (implicated_via_orthology)
Disease	hepatic encephalopathy (biomarker_via_orthology)	GLUD1 GLUD2	3.37e-03	15	172	2	DOID:13413 (biomarker_via_orthology)
Disease	Hemoglobin F Disease	LCN2 TFRC	3.37e-03	15	172	2	C0019025
Disease	hepatocellular carcinoma (biomarker_via_orthology)	ALX4 TFRC AFP DNMT1	3.73e-03	108	172	4	DOID:684 (biomarker_via_orthology)
Disease	sickle cell anemia (is_implicated_in)	CYP2C19 APOB	3.84e-03	16	172	2	DOID:10923 (is_implicated_in)
Disease	level of Sphingomyelin (d32:1) in blood serum	SYNE2 KCNH5	4.34e-03	17	172	2	OBA_2045173
Disease	Myeloid Leukemia	SMC1A SMC3	4.86e-03	18	172	2	C0023470
Disease	Leukemia, Monocytic, Chronic	SMC1A SMC3	4.86e-03	18	172	2	C0023466
Disease	lymphocyte count	EXOC6 RAP1A CYP2C19 AKIRIN1 KIF27 LCORL RBL1 SPEF2 LYST FOCAD SLC45A3 TBC1D1 AP1M1 DDX60L ATP2B4 HTT DNMT1	5.40e-03	1464	172	17	EFO_0004587
Disease	cerebral microbleeds	AMPH LCORL	5.41e-03	19	172	2	EFO_0010059
Disease	hydrocephalus (implicated_via_orthology)	KIF27 HYDIN	5.41e-03	19	172	2	DOID:10908 (implicated_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
YVKTSKFVAFDRIIN	USP26	701	Q9BXU7
NTKLAEQYESFVKFT	AKIRIN1	161	Q9H9L7
FTSYQLEELEKVFQK	ALX4	221	Q9H161
AKDQYIEQFKDTLST	AGXT2	261	Q9BYV1
FLNSSYQTVFKTIIK	ERICH6B	351	Q5W0A0
QDKIIFCFTYEQKQI	ERICH6B	601	Q5W0A0
QKSIYSEFLKRFVEA	ALDH8A1	296	Q9H2A2
IYKVKTVFNNEFDAA	CFAP43	1016	Q8NDM7
KTTVLYRLKFNEFVN	ARL4C	26	P56559
YTKEEQFKQVFKELE	COPS6	106	Q7L5N1
TKLVYQIFDTFFAEQ	DNMT1	621	P26358
VANEYKSVTEFKADF	BRD9	191	Q9H8M2
VFINFAKDQKSYETA	ABCA12	2561	Q86UK0
LNTKLAEQYDAFVKF	AKIRIN2	171	Q53H80
YSELFLEVQKRAQKF	CCDC171	671	Q6TFL3
DQKYIFASLDQKSTV	AKAP13	2266	Q12802
KVVQVFSEYFKELEE	AP1M1	86	Q9BXS5
NVICSVVFQKRFDYK	CYP2C8	176	P10632
VVFQKRFDYKDQNFL	CYP2C8	181	P10632
LAFAIFSSEIDQYQK	DOP1A	2181	Q5JWR5
FNVETVTYKNLKFQV	ARL1	51	P40616
IFNKYLEKVVENSEF	CCDC42	151	Q96M95
EKEYISCQNTVFKSV	CASP8AP2	1581	Q9UKL3
FYNKKVENFTVSFSD	ASPM	1126	Q8IZT6
VYDSISKFLQFQLTV	ATP2B2	871	Q01814
VYDSISKFLQFQLTV	ATP2B4	836	P23634
KQTADFLQEYVTNKT	AKAP8L	426	Q9ULX6
FYVNTFKNVSSLEAK	AMPH	201	P49418
LREFQTYVKSQDKQF	AP3B1	406	O00203
TYVKSQDKQFAAATI	AP3B1	411	O00203
KSFQYSVQIEKPFTE	AP4E1	986	Q9UPM8
KRKSSYTFEQLEQVF	MSANTD2	186	Q6P1R3
TLTVTDFKLYFKNVE	MTMR1	126	Q13613
LFTIYDDQVTFQLFK	RCAN3	71	Q9UKA8
SSAKSKINVNEIFYD	RAP1A	146	P62834
SSAKSKINVNEIFYD	RAP1B	146	P61224
KYVQRKSDFDQTVFQ	NETO1	371	Q8TDF5
SEFEYLFSKDTTQQK	FMN1	1016	Q68DA7
KVAFYNEIFLSVTAI	GPR141	261	Q7Z602
AFKQQFVNYATEKLR	MFN1	641	Q8IWA4
YEITIEVFDKFSNKV	NUP210	366	Q8TEM1
VNSFLDYKNEEVKFI	HDX	601	Q7Z353
KFQNYSSASEVKVDL	LINS1	396	Q8NG48
YSVIEKLSRKFQEAF	MATN1	206	P21941
VFQTKIQEFRKACYT	MAD1L1	621	Q9Y6D9
LVFLFDNSKITYETQ	IKBKB	386	O14920
FLSLQEIQTAYSKFK	MTMR12	321	Q9C0I1
YSKFKQLFLIDNSTE	MTMR12	331	Q9C0I1
QTEEQYFQFLAKFEI	LRRK1	966	Q38SD2
KVTYNVTSFIDKNND	MYO1A	511	Q9UBC5
KFAEVYFAQSQQKVF	MLEC	126	Q14165
KKEFENSYIFDINTI	GAB1	76	Q13480
VTQFKEKNESLQYET	LCORL	391	Q8N3X6
FYVNENTFKERLKLF	KCNT1	71	Q5JUK3
KTIEKVRQTFDNYES	KCNH5	76	Q8NCM2
AVFQKPVKFQVDITY	BRSK2	581	Q8IWQ3
AFKQLSQTFYEKLQE	DDX60L	1681	Q5H9U9
FTKKNSASVVYQADV	FSIP2	376	Q5CZC0
NFIYKVTKNIAFETE	FBXW12	86	Q6X9E4
YKDRQKFSEQVFKVA	FLOT1	121	O75955
SIDFNVKVSYIEVYK	KIF27	126	Q86VH2
KISFDEFVYIFQEVK	PLS3	71	P13797
KSAFLTEVSQKENYA	PNRC1	266	Q12796
FSLVYQDEFVSSQIK	PLXNA3	196	P51805
KFEKAVYRVQLSEFS	FAT2	361	Q9NYQ8
VSKEYNEFAEVFLKA	IPO7	281	O95373
KNIDATVKVFNTVYS	KIAA1586	241	Q9HCI6
KVKEFYSYQNEAVAI	MTTP	131	P55157
IITATQYKKCDEFQT	PEAK1	1581	Q9H792
FQKIVDQSKTYESEQ	PDE6A	681	P16499
SKQDEEVFSKYLNFV	PDE6C	206	P51160
RAFEIFTDNKTYVFK	VEPH1	786	Q14D04
TFESIYLKTFLQEQA	CYB5RL	221	Q6IPT4
EFSISSNIIQFKYFI	KCTD4	186	Q8WVF5
SKQAQFLALAVVYFI	LRBA	1526	P50851
FKATFIIKIIRDEQY	LNPEP	311	Q9UIQ6
TTVKLLEFFQNYFEI	LNPEP	396	Q9UIQ6
SSTIKYLDFVFAVKN	LAMP2	276	P13473
KQEVREANKYFFIES	SLC11A2	286	P49281
FYINITKEENSAFKN	KCNT2	551	Q6UVM3
VAFDETKNVFVKFYA	PDIA2	401	Q13087
QFAIKKTSEDASEYF	PARP4	201	Q9UKK3
TAIALYFAIQDFNKV	PIGU	91	Q9H490
YFAIQDFNKVVFKKQ	PIGU	96	Q9H490
QVKEFIYASLKFSES	EXOC6	491	Q8TAG9
KQQEKSVSVFYAIVT	OR2D2	266	Q9H210
KFLYEVFAQLKDETT	PPP4R3C	311	Q6ZMV5
FASVFVYKRENEDKV	SCYL3	36	Q8IZE3
YEFLDKFKQVFDTTL	METTL21C	231	Q5VZV1
VFFKKVSQNREYFKI	LCN2	141	P80188
VKEVNETYKLLFNFV	PARP14	651	Q460N5
KQFFQDKARFYQSEI	PARP14	751	Q460N5
TIANINQELIKYEFF	FBXO38	1051	Q6PIJ6
IQFTSQFLKLDYFQK	PRAMEF12	256	O95522
EGRYKQKFQSVFTVT	C1QC	111	P02747
QDLKDFFQKVSQVYV	PIKFYVE	1411	Q9Y2I7
NYISEFEIFPKQSQK	FRMD3	171	A2A2Y4
QAFYKLEKSSQVRTV	FRMD5	291	Q7Z6J6
EFTIVAFVKYDKNQD	APOB	2051	P04114
YFKQLFNTTIETSVK	DNAH6	3321	Q9C0G6
QEKEVFKEFIYRINT	HTT	2441	P42858
KEEKFYSQTLVFQIA	HYDIN	1791	Q4G0P3
IIVNNFSEFYKEQKR	KCNB1	411	Q14721
KLLTSNDVVDFFQKY	KMO	246	O15229
IIFQKRFDYKDQQFL	CYP2C19	181	P33261
ENQKQLTFISQKEYF	CCDC175	391	P0C221
VQYSDEVKSEFKLNT	COL12A1	2366	Q99715
FENVFISSKTEKVAY	GCNT7	161	Q6ZNI0
TAAYVNAIEKVFKVY	GLUD1	536	P00367
FFNVTTLQKELYDFA	CRTAP	361	O75718
VVFKYIEDKDVFQKF	CUL1	451	Q13616
ITKEDVKSYLFRNAF	SLC1A3	36	P43003
TIYVDNFDKLKDVFT	COL6A5	971	A8TX70
LVYQIVESTAKKFFT	FAT3	1811	Q8TDW7
VIFNIVNFSKTKSLY	AGBL4	96	Q5VU57
LKAIVFKQYNQTFET	CENPN	201	Q96H22
TFQEETKAQFYASEK	C17orf80	131	Q9BSJ5
SKFSQKIRYVFNLAE	BNIP2	266	Q12982
FQKEIFTYLVEGFKV	LYST	2701	Q99698
VEEKIQEVFSSYKFN	FNTB	51	P49356
NKYSVIDDLIFFASK	KRTAP21-3	41	Q3LHN1
KSIIEIVSYFQRKFQ	EFCAB3	156	Q8N7B9
YKVNTDINFEVFIHK	RRAGD	166	Q9NQL2
IIQVQINFFESSKLY	CFAP47	1146	Q6ZTR5
TAAYVNAIEKVFKVY	GLUD2	536	P49448
TTEYENFKVQVLSFL	FOCAD	681	Q5VW36
FAQFVQEATYKEVSK	AFP	51	P02771
AVEVTKSFIEYIKSQ	KIF1A	1056	Q12756
QSYFKTIEDFQQKIL	KRT36	141	O76013
VFNVIYQSAAVFKLS	PKD1	981	P98161
KQLDFEKFQSYEVNI	PCDHB8	306	Q9UN66
NIIQLKDTYETNTFF	PHKG1	86	Q16816
KFTSKNEVQDYVSVE	MOSPD2	211	Q8NHP6
YFVATQDQNLSVKVK	UTP23	116	Q9BRU9
FFNAKPIYEQASVKT	SPEF2	466	Q9C093
YEAIQLTFKQVSKNF	SMC3	1026	Q9UQE7
YSISEEFLKVKAQAF	TDRD6	866	O60522
NIVSFIEKSYKSIFV	TLR10	681	Q9BXR5
KFFEQYEVTYQILKQ	SYNE1	551	Q8NF91
KKYSQQVVEYDEFTT	SYNE2	2616	Q8WXH0
KAFDTYKALVVSVNV	SYNE2	6601	Q8WXH0
YKALVVSVNVSSKEF	SYNE2	6606	Q8WXH0
TAFTYEQLVALENKF	NKX1-1	301	Q15270
QQIFALEKTFEQTKY	NKX6-1	246	P78426
ERNFEVSTVIFKKYE	RBL1	126	P28749
SLQEFVKAFYLKTND	PSMD7	241	P51665
LTNKFEDKTVAYTEQ	PDIA3	211	P30101
DSKQAQFLALAVVYF	NBEA	1556	Q8NFP9
FQIYTVKIFFSDLSQ	PIK3R6	536	Q5UE93
YISPEQKKEFVTQFT	PRAMEF20	246	Q5VT98
KYQGFIFDIVTKQAF	SCN5A	1516	Q14524
IFEVNKQDIYKSFSR	SCYL2	266	Q6P3W7
QKDVNSLLKYFVTFE	NDUFAF4	146	Q9P032
KVEAFQTTISKYFSE	PSME2	156	Q9UL46
FSERFKVLANQYKSI	ADSS2	191	P30520
ALYVENQFREFKLSK	TFRC	166	P02786
YFATQVVFDKSDLAK	SLC45A3	536	Q96JT2
FFEVLNYETIEQKKA	ASIC1	411	P78348
FTFKQECRIKYSEQV	PPP3CC	156	P48454
SSAKSKINVNEIFYD	nan	146	A6NIZ1
AEIDVIFKDFVNKYT	RNF213	1301	Q63HN8
TQSKIFQCDKYVKVF	ZNF738	171	Q8NE65
NDAVTVVLYNLFKSF	SLC9A2	246	Q9UBY0
FQKFLTEISKLTNDY	SERPINB13	86	Q9UIV8
FKVESEQQYFEIEKR	TPR	46	P12270
QSICYVFKADDQTKV	TBC1D1	126	Q86TI0
SEIVKQSVFKDFYEL	PYGB	461	P11216
LQKYEKTNTFVEFNF	USP29	691	Q9HBJ7
NFQAIVISLKEEFYT	SMC1A	1181	Q14683
TQVAKVFDQYLNFIT	SCFD1	141	Q8WVM8
KNYQVQFVTLKTFEE	GTF3C4	506	Q9UKN8
FNFLNEIKKRFQTTY	VAMP7	76	P51809
FQFAKKFVVYEVLRE	UAP1	386	Q16222
KFIYVAIAQFIETTK	PTPN6	506	P29350
VVVQEFQDYQFKQTK	THUMPD3	96	Q9BV44
FQDYQFKQTKEEVLK	THUMPD3	101	Q9BV44
EITRSFIKQTYQKQD	USP24	641	Q9UPU5
TQSKIFQCDKYVKVF	ZNF493	21	Q6ZR52
FINKKTLANDSIFEY	ZNF484	141	Q5JVG2
TLSKIFQCNKYVEVF	ZNF117	76	Q03924
AVSASIKDEKFFENY	TTC37	1306	Q6PGP7
SEVKSVVINYNHKFI	TRPC6	686	Q9Y210
KVENFFTLYNVKAEI	TRAPPC10	1051	P48553
VEFGQNFYLKSVFIK	ZNF354B	161	Q96LW1
EEVLTFYTQKNKSAS	TTLL5	801	Q6EMB2
VKFKSSNYVLTDEQS	THOC1	336	Q96FV9
NLLVNVKFIFYSSDK	ZFYVE16	1066	Q7Z3T8
NTVQFLEEYCKFKNT	TRIM16L	61	Q309B1
YRKFTAAIQEVQQKT	GAS8	346	O95995
KIFNFAIFKVTAYAV	SLC16A10	281	Q8TF71