Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionmonoatomic ion transmembrane transporter activity

SLC6A3 SLC26A8 CACNG8 NALF1 BEST2 SCN5A TRPV2 ATP13A3 ATP1A1 ATP1A3 CHRFAM7A CHRNA7 RYR2

3.34e-077935813GO:0015075
GeneOntologyMolecularFunctionmonoatomic cation transmembrane transporter activity

SLC6A3 CACNG8 NALF1 BEST2 SCN5A TRPV2 ATP13A3 ATP1A1 ATP1A3 CHRFAM7A CHRNA7 RYR2

3.64e-076645812GO:0008324
GeneOntologyMolecularFunctiontransmembrane transporter activity

SLC6A3 SLC26A8 CACNG8 NALF1 SLC6A16 BEST2 SCN5A TRPV2 ATP13A3 ATP1A1 ATP1A3 CHRFAM7A CHRNA7 RYR2 SLC3A1

9.19e-0711805815GO:0022857
GeneOntologyMolecularFunctiontransporter activity

SLC6A3 SLC26A8 CACNG8 NALF1 SLC6A16 BEST2 SCN5A TRPV2 ATP13A3 ATP1A1 ATP1A3 CHRFAM7A CHRNA7 RYR2 SLC3A1

2.77e-0612895815GO:0005215
GeneOntologyMolecularFunctionmonoatomic cation channel activity

CACNG8 NALF1 BEST2 SCN5A TRPV2 CHRFAM7A CHRNA7 RYR2

6.34e-06343588GO:0005261
GeneOntologyMolecularFunctionmonoatomic ion channel activity

SLC26A8 CACNG8 NALF1 BEST2 SCN5A TRPV2 CHRFAM7A CHRNA7 RYR2

6.50e-06459589GO:0005216
GeneOntologyMolecularFunctionmetal ion transmembrane transporter activity

SLC6A3 CACNG8 NALF1 SCN5A TRPV2 ATP1A1 ATP1A3 CHRNA7 RYR2

7.21e-06465589GO:0046873
GeneOntologyMolecularFunctionscaffold protein binding

SCN5A TREM2 CHRFAM7A CHRNA7 RYR2

7.41e-0693585GO:0097110
GeneOntologyMolecularFunctioninorganic molecular entity transmembrane transporter activity

SLC6A3 SLC26A8 CACNG8 NALF1 BEST2 SCN5A TRPV2 ATP1A1 ATP1A3 CHRNA7 RYR2

9.79e-067585811GO:0015318
GeneOntologyMolecularFunctionamyloid-beta binding

TREM2 ATP1A3 CHRFAM7A CHRNA7 LRP8

1.16e-05102585GO:0001540
GeneOntologyMolecularFunctionchannel activity

SLC26A8 CACNG8 NALF1 BEST2 SCN5A TRPV2 CHRFAM7A CHRNA7 RYR2

1.90e-05525589GO:0015267
GeneOntologyMolecularFunctionpassive transmembrane transporter activity

SLC26A8 CACNG8 NALF1 BEST2 SCN5A TRPV2 CHRFAM7A CHRNA7 RYR2

1.93e-05526589GO:0022803
GeneOntologyMolecularFunctioncalcium channel activity

CACNG8 NALF1 TRPV2 CHRNA7 RYR2

3.63e-05129585GO:0005262
GeneOntologyMolecularFunctionpeptide binding

NPFFR2 TREM2 ATP1A3 CHRFAM7A NPFFR1 CHRNA7 LRP8

3.65e-05318587GO:0042277
GeneOntologyMolecularFunctionprotein tyrosine kinase activity

ABL1 ABL2 DSTYK ZAP70 NRP2

6.33e-05145585GO:0004713
GeneOntologyMolecularFunctioninorganic cation transmembrane transporter activity

SLC6A3 CACNG8 NALF1 SCN5A TRPV2 ATP1A1 ATP1A3 CHRNA7 RYR2

7.55e-05627589GO:0022890
GeneOntologyMolecularFunctioncalcium ion transmembrane transporter activity

CACNG8 NALF1 TRPV2 CHRNA7 RYR2

7.68e-05151585GO:0015085
GeneOntologyMolecularFunctionP-type transmembrane transporter activity

ATP13A3 ATP1A1 ATP1A3

1.55e-0436583GO:0140358
GeneOntologyMolecularFunctionP-type ion transporter activity

ATP13A3 ATP1A1 ATP1A3

1.55e-0436583GO:0015662
GeneOntologyMolecularFunctionsteroid hormone binding

ATP1A1 ATP1A3

1.73e-047582GO:1990239
GeneOntologyMolecularFunctionamide binding

TREM2 ATP1A3 CHRFAM7A CHRNA7 RYR2 LRP8

2.26e-04299586GO:0033218
GeneOntologyMolecularFunctionnon-membrane spanning protein tyrosine kinase activity

ABL1 ABL2 ZAP70

3.23e-0446583GO:0004715
GeneOntologyMolecularFunctionprotein kinase activity

VRK2 ABL1 ABL2 MAP4K1 DSTYK GRK6 ZAP70 NRP2

3.23e-04600588GO:0004672
GeneOntologyMolecularFunctionP-type sodium transporter activity

ATP1A1 ATP1A3

3.68e-0410582GO:0008554
GeneOntologyMolecularFunctionP-type sodium:potassium-exchanging transporter activity

ATP1A1 ATP1A3

3.68e-0410582GO:0005391
GeneOntologyMolecularFunctiongated channel activity

CACNG8 NALF1 BEST2 CHRFAM7A CHRNA7 RYR2

4.08e-04334586GO:0022836
GeneOntologyMolecularFunctionphosphotyrosine residue binding

ABL1 ABL2 ZAP70

4.39e-0451583GO:0001784
GeneOntologyMolecularFunctionP-type potassium transmembrane transporter activity

ATP1A1 ATP1A3

4.48e-0411582GO:0008556
GeneOntologyMolecularFunctionacetylcholine binding

CHRFAM7A CHRNA7

6.34e-0413582GO:0042166
GeneOntologyMolecularFunctionligand-gated monoatomic cation channel activity

BEST2 CHRFAM7A CHRNA7 RYR2

7.32e-04140584GO:0099094
GeneOntologyMolecularFunctionannealing activity

FMR1 SMARCAL1

7.38e-0414582GO:0140666
GeneOntologyMolecularFunctionATPase-coupled monoatomic cation transmembrane transporter activity

ATP13A3 ATP1A1 ATP1A3

7.79e-0462583GO:0019829
GeneOntologyMolecularFunctionhigh-density lipoprotein particle binding

TREM2 LRP8

8.50e-0415582GO:0008035
GeneOntologyMolecularFunctionchloride channel regulator activity

CHRFAM7A CHRNA7

8.50e-0415582GO:0017081
GeneOntologyMolecularFunctionprotein kinase binding

VRK2 ABL1 FMR1 SCN5A TREM2 ATP1A1 CHRFAM7A CHRNA7 RYR2

8.69e-04873589GO:0019901
GeneOntologyMolecularFunctionadenylate cyclase binding

CHRFAM7A CHRNA7

9.69e-0416582GO:0008179
GeneOntologyMolecularFunctionphosphotransferase activity, alcohol group as acceptor

VRK2 ABL1 ABL2 MAP4K1 DSTYK GRK6 ZAP70 NRP2

9.69e-04709588GO:0016773
GeneOntologyMolecularFunctionprotein phosphorylated amino acid binding

ABL1 ABL2 ZAP70

1.06e-0369583GO:0045309
GeneOntologyMolecularFunctionacetylcholine-gated monoatomic cation-selective channel activity

CHRFAM7A CHRNA7

1.10e-0317582GO:0022848
GeneOntologyMolecularFunctiontoxic substance binding

CHRFAM7A CHRNA7

1.23e-0318582GO:0015643
GeneOntologyMolecularFunctiontransferase activity, transferring phosphorus-containing groups

VRK2 ABL1 ABL2 MAP4K1 DSTYK PRIM1 GRK6 ZAP70 NRP2

1.44e-03938589GO:0016772
GeneOntologyMolecularFunctionapolipoprotein binding

TREM2 LRP8

1.52e-0320582GO:0034185
GeneOntologyMolecularFunctionsodium ion transmembrane transporter activity

SLC6A3 SCN5A ATP1A1 ATP1A3

1.54e-03171584GO:0015081
GeneOntologyMolecularFunctionkinase activity

VRK2 ABL1 ABL2 MAP4K1 DSTYK GRK6 ZAP70 NRP2

1.56e-03764588GO:0016301
GeneOntologyMolecularFunctionneurotransmitter transmembrane transporter activity

SLC6A3 SLC6A16

1.68e-0321582GO:0005326
GeneOntologyMolecularFunctionactive monoatomic ion transmembrane transporter activity

SLC6A3 SLC26A8 ATP13A3 ATP1A1 ATP1A3

1.80e-03301585GO:0022853
GeneOntologyMolecularFunctionkinase binding

VRK2 ABL1 FMR1 SCN5A TREM2 ATP1A1 CHRFAM7A CHRNA7 RYR2

1.80e-03969589GO:0019900
GeneOntologyMolecularFunctionankyrin binding

SCN5A ATP1A1

2.02e-0323582GO:0030506
GeneOntologyMolecularFunctionacetylcholine receptor activity

CHRFAM7A CHRNA7

2.02e-0323582GO:0015464
GeneOntologyMolecularFunctionligand-gated monoatomic ion channel activity

BEST2 CHRFAM7A CHRNA7 RYR2

2.39e-03193584GO:0015276
GeneOntologyMolecularFunctionactive transmembrane transporter activity

SLC6A3 SLC26A8 SLC6A16 ATP13A3 ATP1A1 ATP1A3

2.55e-03477586GO:0022804
GeneOntologyMolecularFunctionligand-gated channel activity

BEST2 CHRFAM7A CHRNA7 RYR2

2.57e-03197584GO:0022834
GeneOntologyMolecularFunctionactin monomer binding

ABL1 ABL2

3.20e-0329582GO:0003785
GeneOntologyMolecularFunctionbicarbonate transmembrane transporter activity

SLC26A8 BEST2

3.89e-0332582GO:0015106
GeneOntologyMolecularFunctionATPase-coupled transmembrane transporter activity

ATP13A3 ATP1A1 ATP1A3

3.93e-03109583GO:0042626
GeneOntologyMolecularFunctionintracellularly ligand-gated monoatomic ion channel activity

BEST2 RYR2

4.13e-0333582GO:0005217
GeneOntologyMolecularFunctionlipoprotein particle binding

TREM2 LRP8

4.64e-0335582GO:0071813
GeneOntologyMolecularFunctionprotein-lipid complex binding

TREM2 LRP8

4.64e-0335582GO:0071814
GeneOntologyMolecularFunctionphosphoprotein binding

ABL1 ABL2 ZAP70

4.79e-03117583GO:0051219
GeneOntologyMolecularFunctiontransmembrane signaling receptor activity

NPFFR2 HCAR2 TREM2 ADGRF4 IL17RC CHRFAM7A NPFFR1 CHRNA7 LRP8 NRP2

5.20e-0313535810GO:0004888
GeneOntologyMolecularFunctionchloride transmembrane transporter activity

SLC6A3 SLC26A8 BEST2

5.75e-03125583GO:0015108
GeneOntologyMolecularFunctionexcitatory extracellular ligand-gated monoatomic ion channel activity

CHRFAM7A CHRNA7

6.94e-0343582GO:0005231
GeneOntologyMolecularFunctionmonoatomic anion transmembrane transporter activity

SLC6A3 SLC26A8 BEST2

9.65e-03151583GO:0008509
GeneOntologyMolecularFunctionneuropeptide receptor activity

NPFFR2 NPFFR1

1.04e-0253582GO:0008188
GeneOntologyBiologicalProcessmonoatomic ion transmembrane transport

SLC6A3 SLC26A8 CACNG8 ABL1 NALF1 FMR1 SLC6A16 BEST2 SCN5A TREM2 TRPV2 ATP13A3 ATP1A1 ATP1A3 CHRFAM7A CHRNA7 RYR2

3.37e-0911155617GO:0034220
GeneOntologyBiologicalProcessmonoatomic cation transmembrane transport

SLC6A3 CACNG8 ABL1 NALF1 FMR1 SLC6A16 BEST2 SCN5A TREM2 TRPV2 ATP13A3 ATP1A1 ATP1A3 CHRNA7 RYR2

1.97e-089425615GO:0098655
GeneOntologyBiologicalProcessmonoatomic cation transport

SLC6A3 CACNG8 ABL1 NALF1 FMR1 SLC6A16 BEST2 SCN5A TREM2 TRPV2 ATP13A3 ATP1A1 ATP1A3 CHRFAM7A CHRNA7 RYR2

4.30e-0811575616GO:0006812
GeneOntologyBiologicalProcessinorganic ion transmembrane transport

SLC6A3 SLC26A8 CACNG8 ABL1 NALF1 FMR1 SLC6A16 BEST2 SCN5A TREM2 TRPV2 ATP1A1 ATP1A3 CHRNA7 RYR2

5.42e-0810175615GO:0098660
GeneOntologyBiologicalProcessmonoatomic ion transport

SLC6A3 SLC26A8 CACNG8 ABL1 NALF1 FMR1 SLC6A16 BEST2 SCN5A TREM2 TRPV2 ATP13A3 ATP1A1 ATP1A3 CHRFAM7A CHRNA7 RYR2

7.38e-0813745617GO:0006811
GeneOntologyBiologicalProcesspositive regulation of heart contraction

SCN5A ATP1A1 CHRFAM7A CHRNA7 RYR2

2.14e-0749565GO:0045823
GeneOntologyBiologicalProcessmetal ion transport

SLC6A3 CACNG8 ABL1 NALF1 FMR1 SLC6A16 SCN5A TREM2 TRPV2 ATP1A1 ATP1A3 CHRFAM7A CHRNA7 RYR2

3.12e-0710005614GO:0030001
GeneOntologyBiologicalProcesspositive regulation of blood circulation

SCN5A ATP1A1 CHRFAM7A CHRNA7 RYR2

3.19e-0753565GO:1903524
GeneOntologyBiologicalProcesstransmission of nerve impulse

CACNG8 FMR1 SCN5A ATP1A3 CHRFAM7A CHRNA7

5.83e-07112566GO:0019226
GeneOntologyBiologicalProcessimport into cell

SLC6A3 CACNG8 ABL1 ABL2 NALF1 FMR1 SCN5A TREM2 TRPV2 ATP1A1 ATP1A3 CHRFAM7A CHRNA7 LRP8

7.37e-0710745614GO:0098657
GeneOntologyBiologicalProcessinorganic cation transmembrane transport

SLC6A3 CACNG8 ABL1 NALF1 FMR1 SLC6A16 SCN5A TREM2 TRPV2 ATP1A1 ATP1A3 CHRNA7 RYR2

8.27e-079225613GO:0098662
GeneOntologyBiologicalProcessneuron projection organization

ABL2 TREM2 ATP1A3 CHRFAM7A CHRNA7 LRP8

1.22e-06127566GO:0106027
GeneOntologyBiologicalProcessregulation of membrane potential

ABL1 FMR1 BEST2 SCN5A TREM2 ATP1A1 ATP1A3 CHRFAM7A CHRNA7 RYR2

2.29e-065595610GO:0042391
GeneOntologyBiologicalProcesspositive regulation of heart rate

SCN5A CHRFAM7A CHRNA7 RYR2

2.40e-0635564GO:0010460
GeneOntologyBiologicalProcesshead development

SLC6A3 ABL1 ABL2 SCN5A FLRT3 ZSWIM6 DIAPH3 ATP1A3 DNAH5 SOCS7 LRP8 NRP2

5.19e-069195612GO:0060322
GeneOntologyBiologicalProcesspositive regulation of heart rate involved in baroreceptor response to decreased systemic arterial blood pressure

CHRFAM7A CHRNA7

7.24e-062562GO:0001988
GeneOntologyBiologicalProcessregulation of synapse organization

ABL1 FMR1 TREM2 FLRT3 CHRFAM7A CHRNA7 LRP8 NRP2

9.24e-06387568GO:0050807
GeneOntologyBiologicalProcessregulation of synapse structure or activity

ABL1 FMR1 TREM2 FLRT3 CHRFAM7A CHRNA7 LRP8 NRP2

1.07e-05395568GO:0050803
GeneOntologyBiologicalProcesssynapse organization

ABL1 ABL2 FMR1 TREM2 FLRT3 LNX1 CHRFAM7A CHRNA7 LRP8 NRP2

1.37e-056855610GO:0050808
GeneOntologyBiologicalProcessdendritic spine organization

ABL2 TREM2 CHRFAM7A CHRNA7 LRP8

1.50e-05115565GO:0097061
GeneOntologyBiologicalProcessaction potential

FMR1 SCN5A ATP1A1 CHRFAM7A CHRNA7 RYR2

1.72e-05201566GO:0001508
GeneOntologyBiologicalProcessregulation of amyloid fibril formation

TREM2 CHRFAM7A CHRNA7

1.78e-0519563GO:1905906
GeneOntologyBiologicalProcesscell communication involved in cardiac conduction

SCN5A ATP1A1 ATP1A3 RYR2

1.98e-0559564GO:0086065
GeneOntologyBiologicalProcessbaroreceptor response to decreased systemic arterial blood pressure

CHRFAM7A CHRNA7

2.17e-053562GO:0001982
GeneOntologyBiologicalProcessresponse to amyloid-beta

TREM2 ATP1A3 CHRFAM7A CHRNA7

2.27e-0561564GO:1904645
GeneOntologyBiologicalProcessregulation of system process

ABL1 FMR1 SCN5A ATP1A1 FTO ATP1A3 CHRFAM7A CHRNA7 RYR2 LRP8

2.48e-057345610GO:0044057
GeneOntologyBiologicalProcessneuronal action potential

FMR1 SCN5A CHRFAM7A CHRNA7

2.58e-0563564GO:0019228
GeneOntologyBiologicalProcessassociative learning

ABL1 ABL2 ATP1A3 CHRFAM7A CHRNA7

2.72e-05130565GO:0008306
GeneOntologyBiologicalProcessregulation of blood circulation

ABL1 SCN5A ATP1A1 ATP1A3 CHRFAM7A CHRNA7 RYR2

2.76e-05326567GO:1903522
GeneOntologyBiologicalProcessregulation of long-term synaptic potentiation

ABL1 FMR1 CHRFAM7A CHRNA7

3.29e-0567564GO:1900271
GeneOntologyBiologicalProcessMAPK cascade

NPFFR2 VRK2 ABL1 ABL2 MAP4K1 DSTYK TREM2 ATP1A3 CHRFAM7A CHRNA7 MADD

3.41e-059305611GO:0000165
GeneOntologyBiologicalProcessinorganic ion import across plasma membrane

NALF1 SCN5A TRPV2 ATP1A1 ATP1A3

4.15e-05142565GO:0099587
GeneOntologyBiologicalProcessinorganic cation import across plasma membrane

NALF1 SCN5A TRPV2 ATP1A1 ATP1A3

4.15e-05142565GO:0098659
GeneOntologyBiologicalProcessgeneration of ovulation cycle rhythm

CHRFAM7A CHRNA7

4.33e-054562GO:0060112
GeneOntologyBiologicalProcessDN4 thymocyte differentiation

ABL1 ABL2

4.33e-054562GO:1904157
GeneOntologyBiologicalProcesspositive regulation of establishment of T cell polarity

ABL1 ABL2

4.33e-054562GO:1903905
GeneOntologyBiologicalProcesspositive regulation of ERK1 and ERK2 cascade

ABL1 ABL2 DSTYK TREM2 CHRFAM7A CHRNA7

4.65e-05240566GO:0070374
GeneOntologyBiologicalProcesscell communication by electrical coupling involved in cardiac conduction

ATP1A1 ATP1A3 RYR2

4.72e-0526563GO:0086064
GeneOntologyBiologicalProcessforebrain development

SLC6A3 SCN5A ZSWIM6 ATP1A3 DNAH5 SOCS7 LRP8 NRP2

4.93e-05489568GO:0030900
GeneOntologyBiologicalProcessregulation of heart contraction

SCN5A ATP1A1 ATP1A3 CHRFAM7A CHRNA7 RYR2

5.71e-05249566GO:0008016
GeneOntologyBiologicalProcessregulation of MAPK cascade

NPFFR2 VRK2 ABL1 ABL2 MAP4K1 DSTYK TREM2 CHRFAM7A CHRNA7 MADD

6.01e-058155610GO:0043408
GeneOntologyBiologicalProcesscalcium ion transport

CACNG8 ABL1 NALF1 FMR1 TRPV2 CHRFAM7A CHRNA7 RYR2

6.53e-05509568GO:0006816
GeneOntologyBiologicalProcesscentral nervous system development

SLC6A3 ABL1 ABL2 FMR1 SCN5A TREM2 ZSWIM6 ATP1A3 DNAH5 SOCS7 LRP8 NRP2

7.15e-0511975612GO:0007417
GeneOntologyBiologicalProcessresponse to glycoside

ATP1A1 ATP1A3

7.20e-055562GO:1903416
GeneOntologyBiologicalProcesssensory processing

CHRFAM7A CHRNA7

7.20e-055562GO:0050893
GeneOntologyBiologicalProcesscalcium ion transmembrane transport

CACNG8 ABL1 NALF1 FMR1 TRPV2 CHRNA7 RYR2

8.83e-05392567GO:0070588
GeneOntologyBiologicalProcessbrain development

SLC6A3 ABL1 ABL2 SCN5A ZSWIM6 ATP1A3 DNAH5 SOCS7 LRP8 NRP2

9.30e-058595610GO:0007420
GeneOntologyBiologicalProcesspositive regulation of long-term synaptic potentiation

FMR1 CHRFAM7A CHRNA7

1.07e-0434563GO:1900273
GeneOntologyBiologicalProcessPurkinje myocyte to ventricular cardiac muscle cell communication

SCN5A RYR2

1.08e-046562GO:0086068
GeneOntologyBiologicalProcessPurkinje myocyte to ventricular cardiac muscle cell signaling

SCN5A RYR2

1.08e-046562GO:0086029
GeneOntologyBiologicalProcessregulation of systemic arterial blood pressure by carotid sinus baroreceptor feedback

CHRFAM7A CHRNA7

1.08e-046562GO:0001978
GeneOntologyBiologicalProcessregulation of establishment of T cell polarity

ABL1 ABL2

1.08e-046562GO:1903903
GeneOntologyBiologicalProcesscell communication by electrical coupling

ATP1A1 ATP1A3 RYR2

1.17e-0435563GO:0010644
GeneOntologyBiologicalProcesssynaptic transmission, dopaminergic

SLC6A3 CHRFAM7A CHRNA7

1.17e-0435563GO:0001963
GeneOntologyBiologicalProcessERK1 and ERK2 cascade

ABL1 ABL2 DSTYK TREM2 ATP1A3 CHRFAM7A CHRNA7

1.32e-04418567GO:0070371
GeneOntologyBiologicalProcesscognition

SLC6A3 ABL1 ABL2 TREM2 ATP1A3 CHRFAM7A CHRNA7

1.42e-04423567GO:0050890
GeneOntologyBiologicalProcesspositive regulation of MAPK cascade

ABL1 ABL2 MAP4K1 DSTYK TREM2 CHRFAM7A CHRNA7 MADD

1.45e-04571568GO:0043410
GeneOntologyBiologicalProcessnorepinephrine transport

SLC6A3 CHRFAM7A CHRNA7

1.49e-0438563GO:0015874
GeneOntologyBiologicalProcessheart contraction

SCN5A ATP1A1 ATP1A3 CHRFAM7A CHRNA7 RYR2

1.53e-04298566GO:0060047
GeneOntologyBiologicalProcesscardiac conduction

SCN5A ATP1A1 ATP1A3 RYR2

1.57e-04100564GO:0061337
GeneOntologyBiologicalProcesscell surface receptor protein tyrosine kinase signaling pathway

MYOF ABL1 ABL2 DSTYK FLRT3 ATP1A3 ZAP70 SOCS7 NRP2

1.68e-04747569GO:0007169
GeneOntologyBiologicalProcessheart process

SCN5A ATP1A1 ATP1A3 CHRFAM7A CHRNA7 RYR2

1.86e-04309566GO:0003015
GeneOntologyBiologicalProcesspostsynapse organization

ABL2 TREM2 CHRFAM7A CHRNA7 LRP8 NRP2

2.00e-04313566GO:0099173
GeneOntologyBiologicalProcessregulation of systemic arterial blood pressure by baroreceptor feedback

CHRFAM7A CHRNA7

2.01e-048562GO:0003025
GeneOntologyBiologicalProcessregulation of cardiac muscle cell contraction

SCN5A ATP1A1 RYR2

2.17e-0443563GO:0086004
GeneOntologyBiologicalProcessamyloid fibril formation

TREM2 CHRFAM7A CHRNA7

2.48e-0445563GO:1990000
GeneOntologyBiologicalProcessresponse to temperature stimulus

MYOF TRPV2 ATP1A3 CHRFAM7A CHRNA7

2.50e-04208565GO:0009266
GeneOntologyBiologicalProcesssodium ion transmembrane transport

SLC6A3 SLC6A16 SCN5A ATP1A1 ATP1A3

2.50e-04208565GO:0035725
GeneOntologyBiologicalProcesspositive regulation of CoA-transferase activity

CHRFAM7A CHRNA7

2.57e-049562GO:1905920
GeneOntologyBiologicalProcesscell junction organization

ABL1 ABL2 FMR1 TREM2 FLRT3 LNX1 CHRFAM7A CHRNA7 LRP8 NRP2

2.59e-049745610GO:0034330
GeneOntologyBiologicalProcesslearning

ABL1 ABL2 ATP1A3 CHRFAM7A CHRNA7

2.73e-04212565GO:0007612
GeneOntologyBiologicalProcesstelencephalon development

SCN5A ZSWIM6 ATP1A3 DNAH5 SOCS7 LRP8

2.74e-04332566GO:0021537
GeneOntologyBiologicalProcessneuron projection morphogenesis

ABL1 ABL2 TRPV2 FLRT3 ZSWIM6 CHRFAM7A CHRNA7 LRP8 NRP2

2.85e-04802569GO:0048812
GeneOntologyBiologicalProcessdendrite development

ABL1 ABL2 FMR1 CHRFAM7A CHRNA7 LRP8

2.88e-04335566GO:0016358
GeneOntologyBiologicalProcesspositive regulation of Wnt signaling pathway, planar cell polarity pathway

ABL1 ABL2

3.21e-0410562GO:2000096
GeneOntologyBiologicalProcessSA node cell to atrial cardiac muscle cell signaling

SCN5A RYR2

3.21e-0410562GO:0086018
GeneOntologyBiologicalProcessSA node cell action potential

SCN5A RYR2

3.21e-0410562GO:0086015
GeneOntologyBiologicalProcessmembrane depolarization

ABL1 BEST2 SCN5A ATP1A3

3.27e-04121564GO:0051899
GeneOntologyBiologicalProcessplasma membrane bounded cell projection morphogenesis

ABL1 ABL2 TRPV2 FLRT3 ZSWIM6 CHRFAM7A CHRNA7 LRP8 NRP2

3.33e-04819569GO:0120039
GeneOntologyBiologicalProcessnegative regulation of interleukin-1 beta production

TREM2 CHRFAM7A CHRNA7

3.39e-0450563GO:0032691
GeneOntologyBiologicalProcessblood circulation

MYOF ABL1 SCN5A ATP1A1 ATP1A3 CHRFAM7A CHRNA7 RYR2

3.41e-04648568GO:0008015
GeneOntologyBiologicalProcesscell projection morphogenesis

ABL1 ABL2 TRPV2 FLRT3 ZSWIM6 CHRFAM7A CHRNA7 LRP8 NRP2

3.54e-04826569GO:0048858
GeneOntologyBiologicalProcessregulation of metal ion transport

ABL1 FMR1 SCN5A TREM2 TRPV2 ATP1A1 RYR2

3.60e-04493567GO:0010959
GeneOntologyBiologicalProcessestablishment or maintenance of transmembrane electrochemical gradient

ATP1A1 ATP1A3

3.92e-0411562GO:0010248
GeneOntologyBiologicalProcessregulation of CoA-transferase activity

CHRFAM7A CHRNA7

3.92e-0411562GO:1905918
GeneOntologyBiologicalProcessSA node cell to atrial cardiac muscle cell communication

SCN5A RYR2

3.92e-0411562GO:0086070
GeneOntologyBiologicalProcessregulation of resting membrane potential

TREM2 ATP1A3

3.92e-0411562GO:0060075
GeneOntologyBiologicalProcessbehavioral response to nicotine

CHRFAM7A CHRNA7

3.92e-0411562GO:0035095
GeneOntologyBiologicalProcessimport across plasma membrane

NALF1 SCN5A TRPV2 ATP1A1 ATP1A3

3.97e-04230565GO:0098739
GeneOntologyBiologicalProcessmodulation of chemical synaptic transmission

MYOF CACNG8 ABL1 FMR1 ATP1A3 CHRFAM7A CHRNA7 LRP8

3.97e-04663568GO:0050804
GeneOntologyBiologicalProcessregulation of trans-synaptic signaling

MYOF CACNG8 ABL1 FMR1 ATP1A3 CHRFAM7A CHRNA7 LRP8

4.01e-04664568GO:0099177
GeneOntologyBiologicalProcessregulation of actin filament-based movement

SCN5A ATP1A1 RYR2

4.03e-0453563GO:1903115
GeneOntologyBiologicalProcessregulation of heart rate

SCN5A CHRFAM7A CHRNA7 RYR2

4.17e-04129564GO:0002027
GeneOntologyBiologicalProcesspositive regulation of synaptic transmission

CACNG8 ABL1 FMR1 CHRFAM7A CHRNA7

4.21e-04233565GO:0050806
GeneOntologyBiologicalProcessAV node cell to bundle of His cell signaling

SCN5A RYR2

4.70e-0412562GO:0086027
GeneOntologyBiologicalProcessAV node cell action potential

SCN5A RYR2

4.70e-0412562GO:0086016
GeneOntologyBiologicalProcessregulation of synapse structural plasticity

CHRFAM7A CHRNA7

4.70e-0412562GO:0051823
GeneOntologyBiologicalProcessBergmann glial cell differentiation

ABL1 ABL2

4.70e-0412562GO:0060020
GeneOntologyBiologicalProcesslearning or memory

ABL1 ABL2 TREM2 ATP1A3 CHRFAM7A CHRNA7

5.09e-04373566GO:0007611
GeneOntologyBiologicalProcessresponse to xenobiotic stimulus

SLC6A3 ABL1 ATP1A1 ATP1A3 CHRFAM7A CHRNA7 LRP8

5.24e-04525567GO:0009410
GeneOntologyCellularComponentplasma membrane raft

SLC6A3 MYOF SCN5A TREM2 ATP1A1 CHRFAM7A CHRNA7 LRP8

7.03e-09147588GO:0044853
GeneOntologyCellularComponentmembrane raft

SLC6A3 MYOF SCN5A TREM2 ATP1A1 CHRFAM7A ZAP70 CHRNA7 LRP8

6.39e-07362589GO:0045121
GeneOntologyCellularComponentmembrane microdomain

SLC6A3 MYOF SCN5A TREM2 ATP1A1 CHRFAM7A ZAP70 CHRNA7 LRP8

6.69e-07364589GO:0098857
GeneOntologyCellularComponentaxon

SLC6A3 ABL1 FMR1 SCN5A TRPV2 FLRT3 ATP1A1 ATP1A3 CHRFAM7A CHRNA7 MADD LRP8 NRP2

7.47e-078915813GO:0030424
GeneOntologyCellularComponentspine apparatus

FMR1 CHRFAM7A CHRNA7

1.68e-069583GO:0097444
GeneOntologyCellularComponentpostsynapse

SLC6A3 CACNG8 ABL1 ABL2 FMR1 FLRT3 ATP1A1 ATP1A3 LNX1 CHRFAM7A CHRNA7 LRP8 NRP2

3.28e-0610185813GO:0098794
GeneOntologyCellularComponentneuron to neuron synapse

CACNG8 FMR1 FLRT3 ATP1A1 ATP1A3 LNX1 CHRFAM7A CHRNA7 LRP8

1.28e-05523589GO:0098984
GeneOntologyCellularComponentcaveola

SLC6A3 MYOF SCN5A ATP1A1 LRP8

1.41e-05111585GO:0005901
GeneOntologyCellularComponentpostsynaptic membrane

SLC6A3 CACNG8 FMR1 FLRT3 CHRFAM7A CHRNA7 LRP8 NRP2

1.52e-05405588GO:0045211
GeneOntologyCellularComponentspine apparatus membrane

CHRFAM7A CHRNA7

2.27e-053582GO:0098897
GeneOntologyCellularComponentdistal axon

SLC6A3 ABL1 FMR1 TRPV2 FLRT3 ATP1A3 CHRFAM7A CHRNA7

2.54e-05435588GO:0150034
GeneOntologyCellularComponentsynaptic membrane

SLC6A3 CACNG8 FMR1 FLRT3 ATP1A3 CHRFAM7A CHRNA7 LRP8 NRP2

3.02e-05583589GO:0097060
GeneOntologyCellularComponentphotoreceptor inner segment membrane

ATP1A1 ATP1A3

4.52e-054582GO:0060342
GeneOntologyCellularComponentgrowth cone

ABL1 FMR1 TRPV2 FLRT3 CHRFAM7A CHRNA7

5.93e-05245586GO:0030426
GeneOntologyCellularComponentsite of polarized growth

ABL1 FMR1 TRPV2 FLRT3 CHRFAM7A CHRNA7

7.08e-05253586GO:0030427
GeneOntologyCellularComponenttransmembrane transporter complex

CACNG8 BEST2 SCN5A ATP1A1 ATP1A3 CHRFAM7A CHRNA7 RYR2

9.29e-05523588GO:1902495
GeneOntologyCellularComponenttransporter complex

CACNG8 BEST2 SCN5A ATP1A1 ATP1A3 CHRFAM7A CHRNA7 RYR2

1.31e-04550588GO:1990351
GeneOntologyCellularComponentsarcolemma

CACNG8 SCN5A ATP1A1 ATP1A3 RYR2

1.82e-04190585GO:0042383
GeneOntologyCellularComponentmembrane protein complex

SLC6A3 CACNG8 BEST2 SCN5A DIAPH3 ATP1A1 ATP1A3 CHRFAM7A ZAP70 CHRNA7 SNTB2 SOCS7 RYR2

1.88e-0414985813GO:0098796
GeneOntologyCellularComponentdendritic spine neck

FMR1 ATP1A3

2.69e-049582GO:0044326
GeneOntologyCellularComponentgrowth cone membrane

TRPV2 FLRT3

2.69e-049582GO:0032584
GeneOntologyCellularComponentsperm annulus

ADGB SLC26A8

2.69e-049582GO:0097227
GeneOntologyCellularComponentplasma membrane protein complex

SLC6A3 CACNG8 SCN5A ATP1A1 ATP1A3 CHRFAM7A ZAP70 CHRNA7 SNTB2

2.90e-04785589GO:0098797
GeneOntologyCellularComponentasymmetric synapse

CACNG8 FMR1 FLRT3 ATP1A1 CHRFAM7A CHRNA7 LRP8

3.39e-04477587GO:0032279
GeneOntologyCellularComponentpostsynaptic specialization

CACNG8 FMR1 FLRT3 ATP1A1 CHRFAM7A CHRNA7 LRP8

4.66e-04503587GO:0099572
GeneOntologyCellularComponentsodium:potassium-exchanging ATPase complex

ATP1A1 ATP1A3

4.91e-0412582GO:0005890
GeneOntologyCellularComponentdendritic spine

ABL2 FMR1 ATP1A3 CHRFAM7A CHRNA7

5.55e-04242585GO:0043197
GeneOntologyCellularComponentneuron spine

ABL2 FMR1 ATP1A3 CHRFAM7A CHRNA7

6.08e-04247585GO:0044309
GeneOntologyCellularComponentmonoatomic ion channel complex

CACNG8 BEST2 SCN5A CHRFAM7A CHRNA7 RYR2

6.15e-04378586GO:0034702
GeneOntologyCellularComponentdendritic spine head

FMR1 ATP1A3

8.86e-0416582GO:0044327
GeneOntologyCellularComponentpresynaptic membrane

SLC6A3 FMR1 ATP1A3 CHRFAM7A CHRNA7

1.02e-03277585GO:0042734
GeneOntologyCellularComponentacetylcholine-gated channel complex

CHRFAM7A CHRNA7

1.12e-0318582GO:0005892
GeneOntologyCellularComponentchromocenter

FMR1 PIWIL2

1.12e-0318582GO:0010369
GeneOntologyCellularComponentreplication fork

RADX SMARCAL1 PRIM1

1.28e-0377583GO:0005657
GeneOntologyCellularComponentT-tubule

CACNG8 SCN5A ATP1A1

1.38e-0379583GO:0030315
GeneOntologyCellularComponentglycinergic synapse

CHRFAM7A CHRNA7

1.39e-0320582GO:0098690
GeneOntologyCellularComponentaxolemma

CHRFAM7A CHRNA7

1.54e-0321582GO:0030673
GeneOntologyCellularComponentneuron projection membrane

CACNG8 CHRFAM7A CHRNA7

1.54e-0382583GO:0032589
GeneOntologyCellularComponentcholinergic synapse

CHRFAM7A CHRNA7

1.69e-0322582GO:0098981
GeneOntologyCellularComponentnuclear replisome

SMARCAL1 PRIM1

1.84e-0323582GO:0043601
GeneOntologyCellularComponentreplisome

SMARCAL1 PRIM1

2.18e-0325582GO:0030894
GeneOntologyCellularComponentpostsynaptic specialization membrane

CACNG8 CHRFAM7A CHRNA7 LRP8

2.35e-03201584GO:0099634
GeneOntologyCellularComponentdendrite

CACNG8 ABL1 ABL2 FMR1 ATP1A3 CHRFAM7A CHRNA7 LRP8

2.43e-03858588GO:0030425
GeneOntologyCellularComponentdendritic tree

CACNG8 ABL1 ABL2 FMR1 ATP1A3 CHRFAM7A CHRNA7 LRP8

2.46e-03860588GO:0097447
GeneOntologyCellularComponentcell leading edge

CACNG8 ABL1 ABL2 TRPV2 CHRFAM7A CHRNA7

2.57e-03500586GO:0031252
GeneOntologyCellularComponentaxon terminus

SLC6A3 FMR1 FLRT3 ATP1A3

2.75e-03210584GO:0043679
GeneOntologyCellularComponentpresynapse

SLC6A3 MYOF FMR1 FLRT3 ATP1A3 CHRFAM7A CHRNA7 MADD

2.96e-03886588GO:0098793
GeneOntologyCellularComponentcell surface

SLC6A3 SCN5A TREM2 TRPV2 IL17RC ATP1A3 CHRFAM7A CHRNA7 LRP8

3.33e-031111589GO:0009986
GeneOntologyCellularComponentcell body

SLC6A3 ABL1 FMR1 TRPV2 ATP1A3 CHRFAM7A CHRNA7 LRP8

3.94e-03929588GO:0044297
GeneOntologyCellularComponentneuron projection terminus

SLC6A3 FMR1 FLRT3 ATP1A3

3.99e-03233584GO:0044306
GeneOntologyCellularComponent9+2 motile cilium

ADGB SLC26A8 ATP1A1 DNAH5

4.30e-03238584GO:0097729
GeneOntologyCellularComponentnuclear envelope

MYOF CMTM3 VRK2 ABL1 TMX4 RYR2

4.48e-03560586GO:0005635
GeneOntologyCellularComponentreceptor complex

CACNG8 CHRFAM7A ZAP70 CHRNA7 LRP8 NRP2

5.34e-03581586GO:0043235
GeneOntologyCellularComponentnuclear replication fork

SMARCAL1 PRIM1

6.07e-0342582GO:0043596
GeneOntologyCellularComponentneuronal cell body membrane

SLC6A3 ATP1A3

6.35e-0343582GO:0032809
GeneOntologyCellularComponentsomatodendritic compartment

SLC6A3 CACNG8 ABL1 ABL2 FMR1 ATP1A3 CHRFAM7A CHRNA7 LRP8

6.39e-031228589GO:0036477
GeneOntologyCellularComponentaxonal growth cone

TRPV2 FLRT3

6.94e-0345582GO:0044295
GeneOntologyCellularComponentcell body membrane

SLC6A3 ATP1A3

7.55e-0347582GO:0044298
GeneOntologyCellularComponentneuronal cell body

SLC6A3 ABL1 FMR1 ATP1A3 CHRFAM7A CHRNA7 LRP8

8.09e-03835587GO:0043025
GeneOntologyCellularComponentcation-transporting ATPase complex

ATP1A1 ATP1A3

8.18e-0349582GO:0090533
GeneOntologyCellularComponentpostsynaptic density

CACNG8 FMR1 FLRT3 ATP1A1 LRP8

8.20e-03451585GO:0014069
GeneOntologyCellularComponentSchaffer collateral - CA1 synapse

CACNG8 FMR1 LRP8

9.16e-03155583GO:0098685
GeneOntologyCellularComponentATPase dependent transmembrane transport complex

ATP1A1 ATP1A3

1.02e-0255582GO:0098533
GeneOntologyCellularComponentextrinsic component of cytoplasmic side of plasma membrane

ZAP70 RYR2

1.06e-0256582GO:0031234
GeneOntologyCellularComponentapical plasma membrane

DSTYK ATP1A1 CHRFAM7A CHRNA7 SLC3A1

1.12e-02487585GO:0016324
MousePhenoabnormal behavioral response to xenobiotic

SLC6A3 GRK6 ZSWIM6 ATP1A1 ATP1A3 CHRFAM7A CHRNA7 RYR2 NRP2

1.06e-06309499MP:0009745
MousePhenoabnormal cerebral hemisphere morphology

CACNG8 ABL2 FMR1 ZSWIM6 ATP1A3 DNAH5 CHRFAM7A CHRNA7 SOCS7 LRP8 NRP2

5.38e-065994911MP:0008540
MousePhenoabnormal erythroblast number

IRF2BP2 DIAPH3 CHRFAM7A CHRNA7

6.44e-0635494MP:0011177
MousePhenodecreased erythroblast number

DIAPH3 CHRFAM7A CHRNA7

8.71e-0612493MP:0011179
MousePhenoairway basal cell hyperplasia

CHRFAM7A CHRNA7

1.20e-052492MP:0011115
MousePhenoabnormal airway basal cell differentiation

CHRFAM7A CHRNA7

1.20e-052492MP:0011114
MousePhenoabnormal airway basal cell morphology

CHRFAM7A CHRNA7

1.20e-052492MP:0011113
MousePhenothick ventricular wall

CMTM3 ABL1 SCN5A ATP1A1 RYR2

1.59e-0591495MP:0002953
MousePhenoabnormal erythroblast morphology

IRF2BP2 DIAPH3 CHRFAM7A CHRNA7

1.79e-0545494MP:0011176
MousePhenoabnormal myocardial fiber sodium currents

SCN5A RYR2

3.60e-053492MP:0020347
MousePhenoabnormal macrophage proliferation

NPFFR2 TREM2

3.60e-053492MP:0011985
MousePhenodecreased macrophage proliferation

NPFFR2 TREM2

3.60e-053492MP:0011986
MousePhenoabnormal spatial learning

SLC6A3 FMR1 DSTYK ATP1A3 CHRFAM7A CHRNA7 LRP8

4.58e-05276497MP:0001463
MousePhenoabnormal seizure response to inducing agent

FMR1 ATP1A3 CHRFAM7A CHRNA7 RYR2 NRP2

6.85e-05201496MP:0009357
MousePhenoabnormal nicotine-mediated receptor currents

CHRFAM7A CHRNA7

7.19e-054492MP:0009475
MousePhenoabnormal telencephalon morphology

CACNG8 ABL2 FMR1 ZSWIM6 ATP1A3 DNAH5 CHRFAM7A CHRNA7 SOCS7 LRP8 NRP2

9.05e-058124911MP:0000787
MousePhenoabnormal action potential

SLC6A3 SCN5A ATP1A3 RYR2 MADD

9.85e-05133495MP:0005402
MousePhenoabnormal hippocampus pyramidal cell layer

CACNG8 FMR1 ATP1A3 LRP8

1.09e-0471494MP:0008284
MousePhenoabnormal proerythroblast morphology

IRF2BP2 DIAPH3 CHRFAM7A CHRNA7

1.28e-0474494MP:0002416
MousePhenoabnormal cerebral cortex morphology

ABL2 ZSWIM6 DNAH5 CHRFAM7A CHRNA7 SOCS7 LRP8

1.35e-04328497MP:0000788
MousePhenoabnormal seizure response to pharmacological agent

ATP1A3 CHRFAM7A CHRNA7 RYR2 NRP2

1.58e-04147495MP:0000950
MousePhenofailure of neuromuscular synapse presynaptic differentiation

CHRFAM7A CHRNA7

1.79e-046492MP:0001054
MousePhenoabnormal cerebral cortex pyramidal cell morphology

ABL2 CHRFAM7A CHRNA7

1.87e-0432493MP:0009969
MousePhenothick interventricular septum

CMTM3 ABL1 RYR2

2.05e-0433493MP:0010724
MousePhenoabnormal response to novel object

SLC6A3 CACNG8 FMR1 ATP1A3

2.39e-0487494MP:0003461
MousePhenoseizures

FMR1 SCN5A ATP1A3 CHRFAM7A CHRNA7 RYR2 NRP2

2.40e-04360497MP:0002064
MousePhenoabnormal conditioned place preference behavior

SLC6A3 FMR1 ATP1A3

2.45e-0435493MP:0009711
MousePhenoventricular fibrillation

SCN5A RYR2

2.50e-047492MP:0006110
MousePhenoabnormal forebrain morphology

SLC6A3 CACNG8 ABL2 FMR1 ZSWIM6 ATP1A3 DNAH5 CHRFAM7A CHRNA7 SOCS7 LRP8 NRP2

2.51e-0410724912MP:0000783
MousePhenoabnormal hippocampus layer morphology

CACNG8 FMR1 ATP1A3 LRP8

2.97e-0492494MP:0000813
MousePhenoabnormal GABAergic neuron physiology

CHRFAM7A CHRNA7

3.33e-048492MP:0011987
MousePhenodisorganized myocardium

CMTM3 ABL1 RYR2

3.65e-0440493MP:0002190
MousePhenoincreased locomotor activity

SLC6A3 FMR1 GRK6 ZSWIM6 ATP1A3

3.83e-04178495MP:0031391
MousePhenoimpaired avoidance learning behavior

CACNG8 FMR1 ATP1A3

4.22e-0442493MP:0012312
MousePhenoabnormal myocardial fiber currents

SCN5A RYR2

4.27e-049492MP:0020345
MousePhenoabnormal behavioral response to addictive substance

GRK6 ZSWIM6 ATP1A1 ATP1A3

4.40e-04102494MP:0009748
MousePhenoenhanced behavioral response to addictive substance

GRK6 ATP1A1 ATP1A3

4.85e-0444493MP:0009749
MousePhenoenvironmentally induced seizures

FMR1 ATP1A3 NRP2

5.18e-0445493MP:0009358
MousePhenoatrial fibrillation

SCN5A RYR2

5.32e-0410492MP:0008543
MousePhenoabnormal heart ventricle wall morphology

CMTM3 ABL1 SCN5A ATP1A1 DNAH5 RYR2

5.57e-04296496MP:0031532
MousePhenoabnormal hippocampus neuron morphology

CACNG8 FMR1 ATP1A3 NRP2

6.92e-04115494MP:0009939
MousePhenoimpaired macrophage phagocytosis

GRK6 TREM2 TRPV2

7.07e-0450493MP:0001798
MousePhenoabnormal miniature excitatory postsynaptic currents

CACNG8 FMR1 RYR2 MADD

7.15e-04116494MP:0004753
MousePhenoimpaired spatial working memory

CHRFAM7A CHRNA7

7.77e-0412492MP:0014370
MousePhenoincreased stereotypic behavior

SLC6A3 FMR1 ZSWIM6

8.38e-0453493MP:0001409
MousePhenoabnormal anxiety-related response

SLC6A3 FMR1 SBSPON ATP13A3 ZSWIM6 ATP1A1 ATP1A3 CHRFAM7A CHRNA7

9.47e-04740499MP:0001362
MousePhenoabnormal nervous system electrophysiology

SLC6A3 FMR1 SCN5A ATP1A3 RYR2 MADD

9.68e-04329496MP:0002272
MousePhenoabnormal interventricular septum thickness

CMTM3 ABL1 RYR2

9.85e-0456493MP:0020136
MousePhenoabnormal hippocampus morphology

CACNG8 FMR1 ATP1A3 SOCS7 LRP8 NRP2

9.99e-04331496MP:0000807
MousePhenoabnormal aggression-related behavior

CACNG8 ABL2 FMR1 ZSWIM6

1.00e-03127494MP:0002061
MousePhenoabnormal synaptic physiology

SLC6A3 CACNG8 VRK2 FMR1 ATP1A3 CHRFAM7A CHRNA7 RYR2 MADD LRP8 NRP2

1.02e-0310764911MP:0021009
MousePhenoabnormal hippocampus pyramidal cell morphology

CACNG8 FMR1 ATP1A3

1.04e-0357493MP:0009940
MousePhenofibrillation

SCN5A RYR2

1.07e-0314492MP:0006109
MousePhenoabnormal pituitary secretion

SLC6A3 NPFFR1

1.07e-0314492MP:0001746
MousePhenoabnormal temporal lobe morphology

CACNG8 FMR1 ATP1A3 SOCS7 LRP8 NRP2

1.10e-03337496MP:0000801
MousePhenoabnormal fear/anxiety-related behavior

ADGB SLC6A3 FMR1 SBSPON ATP13A3 ZSWIM6 ATP1A1 ATP1A3 CHRFAM7A CHRNA7

1.12e-039194910MP:0002065
MousePhenoabnormal heart ventricle wall thickness

CMTM3 ABL1 SCN5A ATP1A1 RYR2

1.15e-03227495MP:0020135
MousePhenoabnormal miniature excitatory postsynaptic current amplitude

CACNG8 FMR1

1.23e-0315492MP:0014371
MousePhenomyocardial fiber disarray

CMTM3 ABL1

1.40e-0316492MP:0031131
MousePhenoimpaired learning

CACNG8 FMR1 DSTYK ATP1A3

1.68e-03146494MP:0012315
MousePhenoabnormal GABA-mediated receptor currents

CHRFAM7A CHRNA7

1.78e-0318492MP:0004008
MousePhenoenhanced behavioral response to xenobiotic

GRK6 ATP1A1 ATP1A3

1.80e-0369493MP:0009746
MousePhenoincreased exploration in new environment

SLC6A3 CACNG8 FMR1 ATP1A3

1.85e-03150494MP:0001415
DomainNPFF_rcpt

NPFFR2 NPFFR1

9.48e-062582IPR005395
DomainFABD

ABL1 ABL2

9.48e-062582SM00808
DomainF_actin_bind

ABL1 ABL2

9.48e-062582PF08919
DomainF-actin_binding

ABL1 ABL2

9.48e-062582IPR015015
DomainATPase_P-typ_cation-transptr_C

ATP13A3 ATP1A1 ATP1A3

1.87e-0517583IPR006068
DomainCation_ATPase_C

ATP13A3 ATP1A1 ATP1A3

1.87e-0517583PF00689
DomainCation_ATPase_N

ATP13A3 ATP1A1 ATP1A3

2.24e-0518583PF00690
DomainATPase_P-typ_cation-transptr_N

ATP13A3 ATP1A1 ATP1A3

2.66e-0519583IPR004014
DomainInterferon_reg_fac2-bd1_2_Znf

IRF2BP2 IRF2BP1

2.84e-053582IPR022750
DomainIRF-2BP1_2

IRF2BP2 IRF2BP1

2.84e-053582PF11261
Domain-

ATP13A3 ATP1A1 ATP1A3

1.32e-04325833.40.1110.10
Domain-

ATP13A3 ATP1A1 ATP1A3

1.32e-04325832.70.150.10
DomainP-type_ATPase_IIC

ATP1A1 ATP1A3

1.41e-046582IPR005775
DomainATPase_P-typ_cyto_domN

ATP13A3 ATP1A1 ATP1A3

1.73e-0435583IPR023299
DomainP_typ_ATPase

ATP13A3 ATP1A1 ATP1A3

1.89e-0436583IPR001757
DomainATPase_P-typ_P_site

ATP13A3 ATP1A1 ATP1A3

1.89e-0436583IPR018303
DomainATPASE_E1_E2

ATP13A3 ATP1A1 ATP1A3

1.89e-0436583PS00154
DomainATPase_P-typ_transduc_dom_A

ATP13A3 ATP1A1 ATP1A3

2.05e-0437583IPR008250
DomainE1-E2_ATPase

ATP13A3 ATP1A1 ATP1A3

2.05e-0437583PF00122
DomainSH2

ABL1 ABL2 ZAP70 SOCS7

2.73e-04101584PF00017
DomainSH2

ABL1 ABL2 ZAP70 SOCS7

3.78e-04110584SM00252
DomainSH2

ABL1 ABL2 ZAP70 SOCS7

3.92e-04111584PS50001
DomainSH2

ABL1 ABL2 ZAP70 SOCS7

4.05e-04112584IPR000980
Domain-

ABL1 ABL2 ZAP70 SOCS7

4.05e-041125843.30.505.10
DomainPROTEIN_KINASE_ATP

VRK2 ABL1 ABL2 MAP4K1 DSTYK GRK6 ZAP70

5.27e-04459587PS00107
DomainPkinase_Tyr

ABL1 ABL2 DSTYK ZAP70

6.91e-04129584PF07714
DomainProt_kinase_dom

VRK2 ABL1 ABL2 MAP4K1 DSTYK GRK6 ZAP70

7.66e-04489587IPR000719
DomainPROTEIN_KINASE_DOM

VRK2 ABL1 ABL2 MAP4K1 DSTYK GRK6 ZAP70

8.03e-04493587PS50011
DomainSer-Thr/Tyr_kinase_cat_dom

ABL1 ABL2 DSTYK ZAP70

8.89e-04138584IPR001245
Domain-

ATP1A1 ATP1A3

1.11e-03165821.20.1110.10
DomainATPase_P-typ_TM_dom

ATP1A1 ATP1A3

1.11e-0316582IPR023298
DomainProtein_kinase_ATP_BS

ABL1 ABL2 MAP4K1 DSTYK GRK6 ZAP70

1.12e-03379586IPR017441
DomainKinase-like_dom

VRK2 ABL1 ABL2 MAP4K1 DSTYK GRK6 ZAP70

1.39e-03542587IPR011009
DomainCation_ATPase_N

ATP1A1 ATP1A3

1.40e-0318582SM00831
DomainNA_NEUROTRAN_SYMP_2

SLC6A3 SLC6A16

1.40e-0318582PS00754
DomainSNF

SLC6A3 SLC6A16

1.57e-0319582PF00209
DomainNA_NEUROTRAN_SYMP_1

SLC6A3 SLC6A16

1.57e-0319582PS00610
DomainNA_NEUROTRAN_SYMP_3

SLC6A3 SLC6A16

1.57e-0319582PS50267
DomainNa/ntran_symport

SLC6A3 SLC6A16

1.57e-0319582IPR000175
DomainHAD-like_dom

ATP13A3 ATP1A1 ATP1A3

1.90e-0379583IPR023214
Domain-

CHRFAM7A CHRNA7

2.30e-03235821.20.120.370
DomainAcetylcholine_rcpt_TM

CHRFAM7A CHRNA7

2.30e-0323582IPR027361
DomainTyrKc

ABL1 ABL2 ZAP70

2.59e-0388583SM00219
DomainTyr_kinase_cat_dom

ABL1 ABL2 ZAP70

2.59e-0388583IPR020635
DomainPROTEIN_KINASE_TYR

ABL1 ABL2 ZAP70

3.41e-0397583PS00109
DomainTyr_kinase_AS

ABL1 ABL2 ZAP70

3.41e-0397583IPR008266
Domain-

FUCA2 SLC3A1

5.28e-03355823.20.20.80
DomainIon_trans_dom

SCN5A TRPV2 RYR2

5.35e-03114583IPR005821
DomainIon_trans

SCN5A TRPV2 RYR2

5.35e-03114583PF00520
DomainGlyco_hydro_catalytic_dom

FUCA2 SLC3A1

6.20e-0338582IPR013781
DomainNeurotransmitter_ion_chnl_CS

CHRFAM7A CHRNA7

8.61e-0345582IPR018000
DomainNeur_chan_memb

CHRFAM7A CHRNA7

8.99e-0346582PF02932
PathwayREACTOME_CARDIAC_CONDUCTION

CACNG8 SCN5A ATP1A1 ATP1A3 RYR2

4.49e-05130435M27454
PathwayKEGG_CARDIAC_MUSCLE_CONTRACTION

CACNG8 ATP1A1 ATP1A3 RYR2

9.55e-0579434M17673
PathwayREACTOME_ION_CHANNEL_TRANSPORT

BEST2 TRPV2 ATP1A1 ATP1A3 RYR2

1.88e-04176435MM15718
PathwayREACTOME_ION_CHANNEL_TRANSPORT

BEST2 TRPV2 ATP1A1 ATP1A3 RYR2

2.25e-04183435M997
PathwayREACTOME_ROLE_OF_ABL_IN_ROBO_SLIT_SIGNALING

ABL1 ABL2

2.52e-048432M27351
PathwayREACTOME_OREXIN_AND_NEUROPEPTIDES_FF_AND_QRFP_BIND_TO_THEIR_RESPECTIVE_RECEPTORS

NPFFR2 NPFFR1

2.52e-048432M27291
PathwayREACTOME_OREXIN_AND_NEUROPEPTIDES_FF_AND_QRFP_BIND_TO_THEIR_RESPECTIVE_RECEPTORS

NPFFR2 NPFFR1

2.52e-048432MM14995
PathwayREACTOME_CARDIAC_CONDUCTION

CACNG8 ATP1A1 ATP1A3 RYR2

2.66e-04103434MM15196
PathwayREACTOME_MUSCLE_CONTRACTION

CACNG8 SCN5A ATP1A1 ATP1A3 RYR2

3.64e-04203435M5485
PathwayREACTOME_HIGHLY_CALCIUM_PERMEABLE_POSTSYNAPTIC_NICOTINIC_ACETYLCHOLINE_RECEPTORS

CHRFAM7A CHRNA7

5.88e-0412432MM15312
PathwayREACTOME_ION_HOMEOSTASIS

ATP1A1 ATP1A3 RYR2

5.88e-0454433M27460
PathwayREACTOME_ION_HOMEOSTASIS

ATP1A1 ATP1A3 RYR2

5.88e-0454433MM15202
PathwayBIOCARTA_LIS1_PATHWAY

ABL1 LRP8

8.08e-0414432MM1531
PathwayREACTOME_ACETYLCHOLINE_BINDING_AND_DOWNSTREAM_EVENTS

CHRFAM7A CHRNA7

9.31e-0415432MM14704
PathwayKEGG_MEDICUS_ENV_FACTOR_METALS_TO_NFKB_SIGNALING_PATHWAY

ABL1 ABL2

9.31e-0415432M47816
PathwayWP_SUDDEN_INFANT_DEATH_SYNDROME_SIDS_SUSCEPTIBILITY_PATHWAYS

SCN5A ATP1A3 CHRNA7 RYR2

1.37e-03159434M39373
PathwayBIOCARTA_LIS1_PATHWAY

ABL1 LRP8

1.50e-0319432M22005
PathwayREACTOME_MUSCLE_CONTRACTION

CACNG8 ATP1A1 ATP1A3 RYR2

1.57e-03165434MM15026
PathwayREACTOME_SIGNALING_BY_ROBO_RECEPTORS

ABL1 ABL2

1.67e-0320432MM14974
Pubmed

Abi1/Hssh3bp1 pY213 links Abl kinase signaling to p85 regulatory subunit of PI-3 kinase in regulation of macropinocytosis in LNCaP cells.

ABL1 ABL2 SOCS7

7.19e-071158320598684
Pubmed

Enhancing cognitive function in chronic TBI: The Role of α7 nicotinic acetylcholine receptor modulation.

CHRFAM7A CHRNA7

2.73e-06258238070724
Pubmed

Inflammatory cytokines decrease the expression of nicotinic acetylcholine receptor during the cell maturation.

CHRFAM7A CHRNA7

2.73e-06258219626424
Pubmed

Episodic memory performance predicted by the 2bp deletion in exon 6 of the "alpha 7-like" nicotinic receptor subunit gene.

CHRFAM7A CHRNA7

2.73e-06258217012698
Pubmed

Cholinergic Pathway Suppresses Pulmonary Innate Immunity Facilitating Pneumonia After Stroke.

CHRFAM7A CHRNA7

2.73e-06258226451017
Pubmed

Genetic deletion of α7 nicotinic acetylcholine receptors induces an age-dependent Alzheimer's disease-like pathology.

CHRFAM7A CHRNA7

2.73e-06258234453977
Pubmed

Perinatal hypoxia-ischemia reduces α 7 nicotinic receptor expression and selective α 7 nicotinic receptor stimulation suppresses inflammation and promotes microglial Mox phenotype.

CHRFAM7A CHRNA7

2.73e-06258224757672
Pubmed

Inhibition of pancreatic acinar mitochondrial thiamin pyrophosphate uptake by the cigarette smoke component 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone.

CHRFAM7A CHRNA7

2.73e-06258226999808
Pubmed

Positive allosteric modulators of α7 nicotinic acetylcholine receptors affect neither the function of other ligand- and voltage-gated ion channels and acetylcholinesterase, nor β-amyloid content.

CHRFAM7A CHRNA7

2.73e-06258227129924
Pubmed

Neuroprotection afforded by nicotine against oxygen and glucose deprivation in hippocampal slices is lost in alpha7 nicotinic receptor knockout mice.

CHRFAM7A CHRNA7

2.73e-06258217291692
Pubmed

Sensorimotor gating and spatial learning in α7-nicotinic receptor knockout mice.

CHRFAM7A CHRNA7

2.73e-06258223521765
Pubmed

Effect of α7 nicotinic acetylcholine receptor activation on cardiac fibroblasts: a mechanism underlying RV fibrosis associated with cigarette smoke exposure.

CHRFAM7A CHRNA7

2.73e-06258228258105
Pubmed

Opposite control of body temperature by NPFF1 and NPFF2 receptors in mice.

NPFFR2 NPFFR1

2.73e-06258220554321
Pubmed

The cholinergic anti-inflammatory system limits T cell infiltration into the neurodegenerative CNS, but cannot counteract complex CNS inflammation.

CHRFAM7A CHRNA7

2.73e-06258219344760
Pubmed

Integrin-mediated dendrite branch maintenance requires Abelson (Abl) family kinases.

ABL1 ABL2

2.73e-06258215987940
Pubmed

Loss of α7nAChR enhances endothelial-to-mesenchymal transition after myocardial infarction via NF-κB activation.

CHRFAM7A CHRNA7

2.73e-06258235926661
Pubmed

The alpha7 nicotinic receptor agonist 4OH-GTS-21 protects axotomized septohippocampal cholinergic neurons in wild type but not amyloid-overexpressing transgenic mice.

CHRFAM7A CHRNA7

2.73e-06258217640819
Pubmed

Contribution of α7 nicotinic receptor to airway epithelium dysfunction under nicotine exposure.

CHRFAM7A CHRNA7

2.73e-06258223431157
Pubmed

c-Abl and Arg tyrosine kinases regulate lysosomal degradation of the oncoprotein Galectin-3.

ABL1 ABL2

2.73e-06258220150913
Pubmed

Bidirectional Regulation of Aggression in Mice by Hippocampal Alpha-7 Nicotinic Acetylcholine Receptors.

CHRFAM7A CHRNA7

2.73e-06258229114104
Pubmed

Autophagy is Involved in Neuroprotective Effect of Alpha7 Nicotinic Acetylcholine Receptor on Ischemic Stroke.

CHRFAM7A CHRNA7

2.73e-06258233995108
Pubmed

E-cigarette-induced pulmonary inflammation and dysregulated repair are mediated by nAChR α7 receptor: role of nAChR α7 in SARS-CoV-2 Covid-19 ACE2 receptor regulation.

CHRFAM7A CHRNA7

2.73e-06258232552811
Pubmed

Loss of Nav1.5 expression and function in murine atria containing the RyR2-P2328S gain-of-function mutation.

SCN5A RYR2

2.73e-06258223723061
Pubmed

Reduced CHRNA7 expression in C3H mice is associated with increases in hippocampal parvalbumin and glutamate decarboxylase-67 (GAD67) as well as altered levels of GABA(A) receptor subunits.

CHRFAM7A CHRNA7

2.73e-06258224836856
Pubmed

Modulation of the MAPKs pathways affects Aβ-induced cognitive deficits in Alzheimer's disease via activation of α7nAChR.

CHRFAM7A CHRNA7

2.73e-06258231904546
Pubmed

Studies of sperm from mutant mice suggesting that two neurotransmitter receptors are important to the zona pellucida-initiated acrosome reaction.

CHRFAM7A CHRNA7

2.73e-06258215948184
Pubmed

Alpha7 nicotinic acetylcholine receptor mediates chronic nicotine inhalation-induced cardiopulmonary dysfunction.

CHRFAM7A CHRNA7

2.73e-06258235678315
Pubmed

Age-Associated Tooth Loss and Oral Microbial Dysbiosis in a Mouse Genetic Model of Chronic Nicotine Exposure.

CHRFAM7A CHRNA7

2.73e-06258233117372
Pubmed

RFamide-related peptide-3 receptor gene expression in GnRH and kisspeptin neurons and GnRH-dependent mechanism of action.

NPFFR2 NPFFR1

2.73e-06258222691552
Pubmed

Functional role of alpha7 nicotinic receptor in physiological control of cutaneous homeostasis.

CHRFAM7A CHRNA7

2.73e-06258212628457
Pubmed

Immunohistochemical analyses of alpha1 and alpha3 Na+/K+-ATPase subunit expression in medulloblastomas.

ATP1A1 ATP1A3

2.73e-06258221498719
Pubmed

Activation of α-7 nicotinic acetylcholine receptor reduces ischemic stroke injury through reduction of pro-inflammatory macrophages and oxidative stress.

CHRFAM7A CHRNA7

2.73e-06258225157794
Pubmed

Selective alpha7 nicotinic receptor activation by AZD0328 enhances cortical dopamine release and improves learning and attentional processes.

CHRFAM7A CHRNA7

2.73e-06258219615981
Pubmed

Splenic nerve denervation attenuates depression-like behaviors in Chrna7 knock-out mice via the spleen-gut-brain axis.

CHRFAM7A CHRNA7

2.73e-06258238944290
Pubmed

Nicotine withdrawal-induced inattention is absent in alpha7 nAChR knockout mice.

CHRFAM7A CHRNA7

2.73e-06258228243714
Pubmed

Mesenchymal Stem Cells or Interleukin-6 Improve Episodic Memory of Mice Lacking α7 Nicotinic Acetylcholine Receptors.

CHRFAM7A CHRNA7

2.73e-06258231202708
Pubmed

Prenatal nicotine exposure alters lung function and airway geometry through α7 nicotinic receptors.

CHRFAM7A CHRNA7

2.73e-06258222246862
Pubmed

Stimulation of the α7 nicotinic acetylcholine receptor protects against sepsis by inhibiting Toll-like receptor via phosphoinositide 3-kinase activation.

CHRFAM7A CHRNA7

2.73e-06258224298024
Pubmed

Lung eosinophilia induced by house dust mites or ovalbumin is modulated by nicotinic receptor α7 and inhibited by cigarette smoke.

CHRFAM7A CHRNA7

2.73e-06258229975102
Pubmed

α7-nAChR Knockout Mice Decreases Biliary Hyperplasia and Liver Fibrosis in Cholestatic Bile Duct-Ligated Mice.

CHRFAM7A CHRNA7

2.73e-06258229580318
Pubmed

Alpha-7 Nicotinic Receptor Dampens Murine Osteoblastic Response to Inflammation and Age-Related Osteoarthritis.

CHRFAM7A CHRNA7

2.73e-06258235479080
Pubmed

[Activation of α7 nAChR improves white fat homeostasis and promotes beige adipogenesis and thermogenesis in obese mice].

CHRFAM7A CHRNA7

2.73e-06258238597441
Pubmed

Activation of Nicotinic Acetylcholine Receptors Decreases Apoptosis in Human and Female Murine Pancreatic Islets.

CHRFAM7A CHRNA7

2.73e-06258227471776
Pubmed

Targeting α-7 nicotinic acetylcholine receptor in the enteric nervous system: a cholinergic agonist prevents gut barrier failure after severe burn injury.

CHRFAM7A CHRNA7

2.73e-06258222688057
Pubmed

α7 Nicotinic acetylcholine receptor agonist attenuates neuropathological changes associated with intracerebral hemorrhage in mice.

CHRFAM7A CHRNA7

2.73e-06258222820264
Pubmed

Stimulation of α7-nAChRs coordinates autophagy and apoptosis signaling in experimental knee osteoarthritis.

CHRFAM7A CHRNA7

2.73e-06258233953172
Pubmed

Different Effects of Nicotine and N-Stearoyl-ethanolamine on Episodic Memory and Brain Mitochondria of α7 Nicotinic Acetylcholine Receptor Knockout Mice.

CHRFAM7A CHRNA7

2.73e-06258232028688
Pubmed

Genetic variation in CHRNA7 and CHRFAM7A is associated with nicotine dependence and response to varenicline treatment.

CHRFAM7A CHRNA7

2.73e-06258230089821
Pubmed

Nicotinic acetylcholine receptor activation reduces skeletal muscle inflammation of mdx mice.

CHRFAM7A CHRNA7

2.73e-06258220615555
Pubmed

Nicotine physical dependence in the mouse: involvement of the alpha7 nicotinic receptor subtype.

CHRFAM7A CHRNA7

2.73e-06258215896732
Pubmed

Activation of α7 Nicotinic Acetylcholine Receptor Ameliorates Zymosan-Induced Acute Kidney Injury in BALB/c Mice.

CHRFAM7A CHRNA7

2.73e-06258230429582
Pubmed

A transgenic mouse model reveals fast nicotinic transmission in hippocampal pyramidal neurons.

CHRFAM7A CHRNA7

2.73e-06258221501254
Pubmed

α7-cholinergic receptor mediates vagal induction of splenic norepinephrine.

CHRFAM7A CHRNA7

2.73e-06258221339364
Pubmed

Cardiopulmonary arrest and resuscitation disrupts cholinergic anti-inflammatory processes: a role for cholinergic α7 nicotinic receptors.

CHRFAM7A CHRNA7

2.73e-06258221368056
Pubmed

Genetic variation within the Chrna7 gene modulates nicotine reward-like phenotypes in mice.

CHRFAM7A CHRNA7

2.73e-06258224289814
Pubmed

The Abl and Arg kinases mediate distinct modes of phagocytosis and are required for maximal Leishmania infection.

ABL1 ABL2

2.73e-06258222665498
Pubmed

Requisite role of the cholinergic alpha7 nicotinic acetylcholine receptor pathway in suppressing Gram-negative sepsis-induced acute lung inflammatory injury.

CHRFAM7A CHRNA7

2.73e-06258219949071
Pubmed

Expression of human apolipoprotein A-II and its effect on high density lipoproteins in transgenic mice.

CHRFAM7A CHRNA7

2.73e-0625821400473
Pubmed

Global Regulation of Differential Gene Expression by c-Abl/Arg Oncogenic Kinases.

ABL1 ABL2

2.73e-06258228555614
Pubmed

Reversible inhibition of GABAA receptors by alpha7-containing nicotinic receptors on the vertebrate postsynaptic neurons.

CHRFAM7A CHRNA7

2.73e-06258217204496
Pubmed

The Fat Mass and Obesity-Associated Protein (FTO) Regulates Locomotor Responses to Novelty via D2R Medium Spiny Neurons.

SLC6A3 FTO

2.73e-06258231189104
Pubmed

Activation of Alpha 7 Cholinergic Nicotinic Receptors Reduce Blood-Brain Barrier Permeability following Experimental Traumatic Brain Injury.

CHRFAM7A CHRNA7

2.73e-06258226937017
Pubmed

α7 nicotinic receptors play a role in regulation of cardiac hemodynamics.

CHRFAM7A CHRNA7

2.73e-06258237017608
Pubmed

Impaired hippocampal theta oscillations in the mice null alpha7 nicotinic acetylcholine receptors.

CHRFAM7A CHRNA7

2.73e-06258223795917
Pubmed

Diminished α7 nicotinic acetylcholine receptor (α7nAChR) rescues amyloid-β induced atrial remodeling by oxi-CaMKII/MAPK/AP-1 axis-mediated mitochondrial oxidative stress.

CHRFAM7A CHRNA7

2.73e-06258236603528
Pubmed

Endogenous signaling through alpha7-containing nicotinic receptors promotes maturation and integration of adult-born neurons in the hippocampus.

CHRFAM7A CHRNA7

2.73e-06258220592195
Pubmed

Activation of α7nAChR Promotes Diabetic Wound Healing by Suppressing AGE-Induced TNF-α Production.

CHRFAM7A CHRNA7

2.73e-06258226650489
Pubmed

Increased sensitivity to nicotine-induced seizures in mice expressing the L250T alpha 7 nicotinic acetylcholine receptor mutation.

CHRFAM7A CHRNA7

2.73e-06258211854451
Pubmed

Lack of modulation of nicotinic acetylcholine alpha-7 receptor currents by kynurenic acid in adult hippocampal interneurons.

CHRFAM7A CHRNA7

2.73e-06258222848433
Pubmed

Nicotine prevents synaptic impairment induced by amyloid-β oligomers through α7-nicotinic acetylcholine receptor activation.

CHRFAM7A CHRNA7

2.73e-06258223842742
Pubmed

Abeta(1-42) modulation of Akt phosphorylation via alpha7 nAChR and NMDA receptors.

CHRFAM7A CHRNA7

2.73e-06258217292512
Pubmed

Impaired attention is central to the cognitive deficits observed in alpha 7 deficient mice.

CHRFAM7A CHRNA7

2.73e-06258216650968
Pubmed

Microglial cell response in α7 nicotinic acetylcholine receptor-deficient mice after systemic infection with Escherichia coli.

CHRFAM7A CHRNA7

2.73e-06258235413868
Pubmed

Circulating brain microvascular endothelial cells (cBMECs) as potential biomarkers of the blood-brain barrier disorders caused by microbial and non-microbial factors.

CHRFAM7A CHRNA7

2.73e-06258223637989
Pubmed

The expression of the non-receptor tyrosine kinases Arg and c-abl is differently modulated in B lymphoid cells at different stages of differentiation.

ABL1 ABL2

2.73e-06258212220663
Pubmed

Genomic organization and partial duplication of the human alpha7 neuronal nicotinic acetylcholine receptor gene (CHRNA7).

CHRFAM7A CHRNA7

2.73e-0625829782083
Pubmed

Long-term improvements in sensory inhibition with gestational choline supplementation linked to α7 nicotinic receptors through studies in Chrna7 null mutation mice.

CHRFAM7A CHRNA7

2.73e-06258224462939
Pubmed

Probing the putative α7 nAChR/NMDAR complex in human and murine cortex and hippocampus: Different degrees of complex formation in healthy and Alzheimer brain tissue.

CHRFAM7A CHRNA7

2.73e-06258229261717
Pubmed

Altered hippocampal circuit function in C3H alpha7 null mutant heterozygous mice.

CHRFAM7A CHRNA7

2.73e-06258218199426
Pubmed

Stroke-induced activation of the α7 nicotinic receptor increases Pseudomonas aeruginosa lung injury.

CHRFAM7A CHRNA7

2.73e-06258222490926
Pubmed

Kynurenic acid blunts A1 astrocyte activation against neurodegeneration in HIV-associated neurocognitive disorders.

CHRFAM7A CHRNA7

2.73e-06258236997969
Pubmed

Loss of dendrite stabilization by the Abl-related gene (Arg) kinase regulates behavioral flexibility and sensitivity to cocaine.

ABL1 ABL2

2.73e-06258219805386
Pubmed

A phenotype for the alpha 7 nicotinic acetylcholine receptor null mutant.

CHRFAM7A CHRNA7

2.73e-06258215364017
Pubmed

Choline, an alpha7 nicotinic acetylcholine receptor agonist, alleviates hyperalgesia in a rat osteoarthritis model.

CHRFAM7A CHRNA7

2.73e-06258223769729
Pubmed

Mice deficient in CHRNA7, a subunit of the nicotinic acetylcholine receptor, produce sperm with impaired motility.

CHRFAM7A CHRNA7

2.73e-06258215944242
Pubmed

Dendritic spine alterations in the hippocampus and parietal cortex of alpha7 nicotinic acetylcholine receptor knockout mice.

CHRFAM7A CHRNA7

2.73e-06258223270857
Pubmed

Neuronal nicotinic alpha7 receptors modulate inflammatory cytokine production in the skin following ultraviolet radiation.

CHRFAM7A CHRNA7

2.73e-06258218077004
Pubmed

Smoking in adult attention-deficit/hyperactivity disorder: interaction between 15q13 nicotinic genes and Temperament Character Inventory scores.

CHRFAM7A CHRNA7

2.73e-06258219462340
Pubmed

Performance deficit of alpha7 nicotinic receptor knockout mice in a delayed matching-to-place task suggests a mild impairment of working/episodic-like memory.

CHRFAM7A CHRNA7

2.73e-06258216923147
Pubmed

NMR structural analysis of alpha-bungarotoxin and its complex with the principal alpha-neurotoxin-binding sequence on the alpha 7 subunit of a neuronal nicotinic acetylcholine receptor.

CHRFAM7A CHRNA7

2.73e-06258211790782
Pubmed

c-Abl and Arg are activated in human primary melanomas, promote melanoma cell invasion via distinct pathways, and drive metastatic progression.

ABL1 ABL2

2.73e-06258221892207
Pubmed

A role of the subdiaphragmatic vagus nerve in depression-like phenotypes in mice after fecal microbiota transplantation from Chrna7 knock-out mice with depression-like phenotypes.

CHRFAM7A CHRNA7

2.73e-06258233422641
Pubmed

Nicotinic ACh receptor α7 inhibits PDGF-induced migration of vascular smooth muscle cells by activating mitochondrial deacetylase sirtuin 3.

CHRFAM7A CHRNA7

2.73e-06258230270436
Pubmed

Activation of α-7 Nicotinic Acetylcholine Receptor Attenuates Cardiac Inflammation Through NLRP3/Caspase-1/IL-18 Pathway.

CHRFAM7A CHRNA7

2.73e-06258234988776
Pubmed

Genetic deletion of α7 nAChRs reduces hippocampal granule and pyramidal cell number in both sexes but impairs pattern separation in males only.

CHRFAM7A CHRNA7

2.73e-06258237746145
Pubmed

Genetic analysis in post-mortem samples with micro-ischemic alterations.

SCN5A RYR2

2.73e-06258228086167
Pubmed

A 2-base pair deletion polymorphism in the partial duplication of the alpha7 nicotinic acetylcholine gene (CHRFAM7A) on chromosome 15q14 is associated with schizophrenia.

CHRFAM7A CHRNA7

2.73e-06258219631623
Pubmed

The fat mass and obesity associated gene (Fto) regulates activity of the dopaminergic midbrain circuitry.

SLC6A3 FTO

2.73e-06258223817550
Pubmed

Inhibition of cell migration by Abl family tyrosine kinases through uncoupling of Crk-CAS complexes.

ABL1 ABL2

2.73e-06258211279004
Pubmed

Deletion of the alpha7 nicotinic receptor subunit gene results in increased sensitivity to several behavioral effects produced by alcohol.

CHRFAM7A CHRNA7

2.73e-06258215770102
InteractionTYROBP interactions

TMX4 TREM2 ATP13A3 ATP1A3 ZAP70

4.54e-0688565int:TYROBP
GeneFamilySH2 domain containing

ABL1 ABL2 ZAP70 SOCS7

7.18e-05101404741
GeneFamilyATPase Na+/K+ transporting subunits

ATP1A1 ATP1A3

9.95e-0574021208
GeneFamilyNeuropeptide receptors

NPFFR2 NPFFR1

2.12e-0410402854
GeneFamilySolute carriers

SLC6A3 SLC26A8 SLC6A16 SLC3A1

1.10e-02395404752
ToppCelldroplet-Lung-immune-endo-depleted-3m-Myeloid|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MYOF RADX TRPV2 ATP13A3 MADD LRP8

1.37e-071825863dec003bad0f3716cf8163861a9d4302a7d6df8c
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

MYOF NALF1 DIAPH3 ATP1A1 LNX1 DNAH5

1.61e-0718758687b3d0478693d4c54ff06b74e5903036b9c1ee6a
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

MYOF NALF1 DIAPH3 ATP1A1 LNX1 DNAH5

1.61e-0718758642a1267bfc27b4460b8409ada580a87c4385841c
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

MYOF NALF1 DIAPH3 ATP1A1 LNX1 DNAH5

1.61e-0718758664afdea159f5e67a1e5cea35ce898aae6e80aea5
ToppCellBrain_organoid-organoid_Kanton_Nature-Organoid-4M-Neuronal-ventral_progenitors_and_neurons_1|Organoid-4M / Sample Type, Dataset, Time_group, and Cell type.

NPFFR2 CACNG8 FLRT3 ATP1A1 ATP1A3 RYR2

1.77e-071905866e92c78799f34b31d098854503c796edb0dc7f80
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

MYOF NALF1 DIAPH3 ATP1A1 LNX1 DNAH5

1.82e-071915865a67ff17fb4b9eff641176dff07830c9cd73754e
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

MYOF NALF1 DIAPH3 ATP1A1 LNX1 DNAH5

1.82e-0719158655ab2854a02cdcfc395e49870ccb7290b5e5471d
ToppCellfacs-Liver-Liver_non-hepato/SCs-18m-Lymphocytic-T_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNG8 RADX MAP4K1 DIAPH3 ZAP70

3.74e-061805858cef63866c205df3825df84ce51fa61aa04ae491
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

MYOF NALF1 DIAPH3 ATP1A1 DNAH5

4.87e-061905853fc9e18c7441c0ae8cda65753cc42d0520f4e116
ToppCellCOVID-19-kidney-TAL|kidney / Disease (COVID-19 only), tissue and cell type

MYOF NALF1 ATP1A1 LNX1 DNAH5

5.66e-0619658504f5eb206ed3016a737609a3ebac0c1fcabb94ef
ToppCellNS-critical-LOC-Myeloid-Macrophage|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

MYOF TREM2 TMEM176A FUCA2 NRP2

5.81e-061975855fb0696376a5501b7c87e0f2f5e4fff3da2903f2
ToppCellCF-Myeloid-Monocyte_Macrophage|CF / Disease state, Lineage and Cell class

MYOF ABL2 TREM2 TMEM176A NRP2

6.10e-06199585bf95eacb31a4a847350f9d6e95ca76c6b730c400
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW19-Neuronal-Intermediate|GW19 / Sample Type, Dataset, Time_group, and Cell type.

RADX MAP4K1 TMEM176A DNAH5

1.83e-05120584eb5b88c47dd4a6f9b55ace24f19d4e81d4ed31e1
ToppCellPBMC-Severe-Myeloid-Classical_Monocyte-Classical_Monocyte-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

MYOF SLC26A8 CACNG8 TMEM176A

3.07e-0513758412caa8ed7cc9e7a0f78c14ad5efe2fc28c3ce9be
ToppCell343B-Myeloid-Macrophage-SPP1+_Macrophage_3|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

ADGB ABL2 DSTYK TREM2

3.73e-051445845e948d4cb913ccd8f82262a1b4d20967aadab3ab
ToppCellEntopeduncular-Macroglia-POLYDENDROCYTE|Entopeduncular / BrainAtlas - Mouse McCarroll V32

ADGB MAP4K1 DIAPH3 DNAH5

3.94e-05146584a317f14a1aab11ffcce65baeb1c475c04324315f
ToppCellfacs-Heart-LV-18m-Mesenchymal-atrial_cardiomyocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HCAR2 DIAPH3 ATP1A3 LRP8

4.49e-051515845893a51585a65f1902cf85124a5ed9f02b4eb82a
ToppCellfacs-Heart-LV-18m-Mesenchymal-atrial_myocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HCAR2 DIAPH3 ATP1A3 LRP8

4.49e-05151584771224e0d6fccfa4225b3adccd7bc22a89a40793
ToppCellLPS-IL1RA+antiTNF-Epithelial_airway|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ADGB FBXO16 ADGRF4 DNAH5

6.19e-05164584e4d4c59aebe5cacd4ecdb907facd044dc82a831d
ToppCelldroplet-Liver-LIVER_HEPATOCYTES-30m-Myeloid-Kupffer_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SBSPON PIWIL2 LNX1 DNAH5

6.64e-05167584cf6206c506715cd846799c62cf7c06e3fa99f7af
ToppCellPND07-Immune-Immune_Myeloid-Monocytic-Macrophage-AM-AM_prolif|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

MYOF RADX ATP13A3 FUCA2

6.80e-05168584a1755afa2cc50960ba60e07d84d61be429cdea72
ToppCellfacs-Heart-LV-18m-Myeloid|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HCAR2 TREM2 ATP1A3 LRP8

7.12e-051705844eaa22040e475100061475123aefa32b56481464
ToppCellfacs-Heart-LV-18m-Myeloid-monocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HCAR2 TREM2 ATP1A3 LRP8

7.12e-0517058460041b2e57e958f300a5bc76851705c8baf297c2
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1-3_VIP_SSTR1|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SLC6A16 BEST2 CHRFAM7A CHRNA7

7.12e-05170584667443062882642211ad116043775ef8eda38859
ToppCellfacs-Heart-LV-18m-Myeloid-monocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HCAR2 TREM2 ATP1A3 LRP8

7.12e-05170584793dde64f5517538b66de5f461a445c4ad6dd7b3
ToppCelldroplet-Liver-LIVER_HEP-30m-Myeloid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADGB MYOF VRK2 SBSPON

7.45e-051725843f784aed340b50ddbec3f7dc0a5279180d38a2bb
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1-3_VIP_SSTR1|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SLC6A16 CHRFAM7A CHRNA7 NRP2

7.45e-05172584458fe1ae92620882dbc95c989a6da9b2ca216b5b
ToppCellE18.5-Immune-Immune_Myeloid-Monocytic-Macrophage-AM-AM_mature|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

HCAR2 MAP4K1 TREM2 TRPV2

7.62e-05173584279efbab7810fa60ab12ea5d09a84800df4adef0
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1_SST_CXCL14|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SCN5A TMEM176A CHRFAM7A CHRNA7

7.62e-051735840ba64e5385fe714f876002520f8b5202809bf11e
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ADGB HCAR2 CACNG8 DIAPH3

7.79e-0517458484da9faff088d05233183b425385beb054c92d1b
ToppCellfacs-Lung-ENDOMUCIN-18m-Endothelial-Lymphatic_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SBSPON FLRT3 SOCS7 NRP2

7.96e-051755849d082ba0e350162aa6e71b668be074b12a27c7ab
ToppCellfacs-Lung-ENDOMUCIN-18m-Endothelial-endothelial_cell_of_lymphatic_vessel|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SBSPON FLRT3 SOCS7 NRP2

7.96e-05175584f641f34b52aec5d047430a6f9d026e915da6c11d
ToppCelldroplet-Pancreas-Endocrine-21m-Epithelial-pancreatic_ductal_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MYOF CMTM3 SBSPON SCN5A

7.96e-05175584c1a8a55af825d5913095f919fa860828df9c273e
ToppCelldroplet-Pancreas-Endocrine-21m-Epithelial-pancreatic_ductal_cel|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MYOF CMTM3 SBSPON SCN5A

7.96e-0517558478b453e220218c84557f244ef7a760e4a1952761
ToppCellE18.5-Immune-Immune_Myeloid-Monocytic-Macrophage-AM|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

HCAR2 MAP4K1 TREM2 TRPV2

8.14e-051765846548797336c9f4ca0f38e74a2c629e2a4defa252
ToppCell3'-Broncho-tracheal-Immune_Myeloid-Dendritic-dendritic_cell|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

TMEM176A CHRFAM7A NPFFR1 CHRNA7

8.32e-05177584aa56129d2d5a73a10e33b7162233a4d9337ee535
ToppCell3'-Broncho-tracheal-Immune_Myeloid-Dendritic-dendritic_cell-Migratory_DCs-Migratory_DCs_L.1.2.1.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

TMEM176A CHRFAM7A NPFFR1 CHRNA7

8.32e-05177584d78a6003ce2d15d7771ae385de252eec7e3c3eea
ToppCell3'-Adult-LargeIntestine-Endothelial-lymphatic_endothelial-LEC1_(ACKR4+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CMTM3 SBSPON CHRFAM7A NRP2

8.32e-05177584dfaed388926ce050730492a532824af68bf4feff
ToppCell3'-Broncho-tracheal-Immune_Myeloid-Dendritic-dendritic_cell-Migratory_DCs|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

TMEM176A CHRFAM7A NPFFR1 CHRNA7

8.32e-0517758470ca5b6fde2e38af1eb88a7d6e8746edba298191
ToppCelldroplet-Liver-LIVER_HEP-30m-Myeloid-Kupffer_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADGB MYOF VRK2 SBSPON

8.32e-0517758414fb8d182775dfd0e49aa7e4e12543a85b3b8bd6
ToppCellCOPD-Endothelial-VE_Venous|Endothelial / Disease state, Lineage and Cell class

MYOF NALF1 TMEM176A ATP1A1

8.69e-05179584e816dd846a6918ec143b57a380c3a47ed073b66e
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

GCNA MYOF NALF1 ATP1A1

9.27e-05182584a8cc56f32efe180e8fb5d69dbe606a794b3db700
ToppCell5'-GW_trimst-2-LargeIntestine-Neuronal-neurons_B-Branch_B3_(IPAN)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CACNG8 SCN5A ATP1A3 CHRFAM7A

9.47e-0518358491764095f7ea4bc806ef6c7b841fc5e5e90faf5f
ToppCell3'_v3-lymph-node_spleen-Myeloid_Mac-Macrophage|lymph-node_spleen / Manually curated celltypes from each tissue

MYOF HCAR2 TREM2 NRP2

9.47e-051835840bcbd60e10b9d6898915dab1987fd46dc7238b19
ToppCell3'-Pediatric_IBD-SmallIntestine-Hematopoietic-Myeloid-Lymphoid_DC|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TREM2 TMEM176A NPFFR1 NRP2

9.47e-051835849ca4954faaba50466c35121d6765895e955178aa
ToppCelldroplet-Spleen-nan-24m-Lymphocytic-immature_NKT_cell|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PRIM1 PIWIL2 DIAPH3 ZAP70

9.67e-05184584b998803180322a5ea2b567928dea531c26816c3c
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SCN5A ATP1A3 CHRFAM7A CHRNA7

9.87e-0518558416e9ccea0e3b95d90dc48ef74206c805681dac0b
ToppCellsaliva-Severe-critical_progression_d12-22_no-steroids-Myeloid-Macrophage-macrophage,_alveolar-Macro_c1-C1QC|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

TREM2 TRPV2 TMEM176A NRP2

9.87e-051855840e8064bb317f26959d3c59b4f73d0c455161ccd7
ToppCelldroplet-Lung-nan-21m-Lymphocytic-T_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

BEST2 PRIM1 TMEM176A ZAP70

1.01e-041865848fc0487fc1b2fd403bd7c257fcabbff652f971c9
ToppCelldroplet-Marrow-BM-1m-Myeloid-promonocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CMTM3 VRK2 TREM2 TRPV2

1.03e-04187584028e7d6e1211e123879d2f353dc32fae1185dd8e
ToppCellCOVID-19-kidney-Mito-rich_Distal|kidney / Disease (COVID-19 only), tissue and cell type

NALF1 ATP1A1 LNX1 DNAH5

1.03e-041875842ce8038d9d1302e850c1bb536e755598f77ba4b9
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SLC6A3 MYOF NALF1 NRP2

1.05e-04188584b21e93a70583c30d05c0833cd3d4d4bca44a039e
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-3m-Macroglial-oligodendrocyte_precursor_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNG8 NALF1 LNX1 DNAH5

1.05e-04188584a244fcd092d5bd544e503366b1439b0fbc1ee00e
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell-Parietal_Epithelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SLC6A3 MYOF NALF1 NRP2

1.05e-04188584874404a4fd9aa42873f6c53dc42da22d3b0fdb9e
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-3m-Macroglial-Oligodendrocyte_progenitor_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNG8 NALF1 LNX1 DNAH5

1.05e-04188584c8530c9ff98666c64a94683261af4288cb790a7e
ToppCelldroplet-Lung-30m-Hematologic-myeloid-alveolar_macrophage-alveolar_macrophage|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

IRF2BP2 MYOF RADX ATP13A3

1.07e-0418958498f517af255ef234eefc3ed7e6c1d63331ab8af0
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Macula_Densa_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

MYOF NALF1 ATP1A1 LNX1

1.07e-04189584e059be2965cca70ff5576df055d0af1775b76e00
ToppCelldroplet-Lung-30m-Hematologic-myeloid-alveolar_macrophage|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

IRF2BP2 MYOF RADX ATP13A3

1.07e-04189584f7e9b6e6a4de297b660a5b6c9a62f860c147185e
ToppCell3'_v3-lymph-node_spleen-Myeloid_Mac|lymph-node_spleen / Manually curated celltypes from each tissue

MYOF HCAR2 TREM2 NRP2

1.07e-04189584aac79c41ce7acba722c45c016b2c6997fb772a96
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

NALF1 DIAPH3 DNAH5 NRP2

1.07e-041895848c8ca3b30d9be6c854615459a7bfba82b427c8bc
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

NALF1 DIAPH3 DNAH5 NRP2

1.07e-041895845d902a4660a27548764bf04c6de152b565da835c
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

MYOF DIAPH3 ATP1A1 LNX1

1.09e-04190584bf4511395fa97efd1c1cd17cc9bebb0271ee7f0e
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

MYOF DIAPH3 ATP1A1 LNX1

1.09e-04190584b6b8964b4910083499681b5fdf554e127b6a4c4e
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_2|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SCN5A ATP1A3 CHRFAM7A CHRNA7

1.12e-04191584764c3a8829ae1253a0790744138266e81fc075ec
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

MYOF DIAPH3 ATP1A1 LNX1

1.12e-041915842fa1b9e76a0ed2d2f0de74349e266cf4a5f51aad
ToppCellCOPD-Endothelial-VE_Arterial|Endothelial / Disease state, Lineage and Cell class

MYOF NOMO2 ATP13A3 ATP1A1

1.12e-04191584ef16ad1c1cd2c0c0377957398c98775b62a81754
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

MYOF DIAPH3 LNX1 DNAH5

1.12e-041915849032aa974aa1b7b1095b8d1b58dcb087358a5001
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

MYOF DIAPH3 LNX1 DNAH5

1.12e-041915845717809a1476c20f65bce722c5a57cff92ee0d7a
ToppCell11.5-Airway-Epithelial-Epithelial|Airway / Age, Tissue, Lineage and Cell class

SCN5A TMEM176A ATP1A3 CHRNA7

1.14e-04192584a77d3692ff02ef7e066a9bd9e22725055a25c4d4
ToppCellControl-Endothelial-VE_Arterial|Endothelial / Disease state, Lineage and Cell class

MYOF NOMO2 ATP13A3 ATP1A1

1.14e-041925847e89b9125e8b85f6be85eeccef5c8644647ab0e1
ToppCellsaliva-Mild-Moderate_progression_d12-25-Myeloid-Monocytic-Nonclassical_Monocyte-Mono_c4-CD14-CD16|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

MYOF CMTM3 TREM2 TRPV2

1.16e-04193584f492ed02a46f3a45dc6005f9f18ab12a84bfa2a3
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

MYOF DIAPH3 ATP1A1 DNAH5

1.16e-04193584f42a0f02ed00fe1bb833ff0a0640d9131bca89bd
ToppCellEC-Sinusoidal_ECs|EC / Lineage and Cell class

CMTM3 TMEM176A ZSWIM6 NRP2

1.16e-041935841291b1d3494dcb4b9309f8bff63fb662e7eca0c8
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

MYOF DIAPH3 ATP1A1 DNAH5

1.16e-0419358442df7ed37d11fb542b4d1d714b6f87ae8e1396a6
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

MYOF DIAPH3 ATP1A1 DNAH5

1.19e-04194584e577d9e88390b36b5a09b97fe1026089892275a3
ToppCell10x_5'_v1-Non-neoplastic-Myeloid-TAM-MG-TAM-MG_pro-infl_II|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

ABL2 TREM2 TMEM176A NRP2

1.19e-04194584d4ca32232ff543ce2101c29af215de1ac0dfd511
ToppCell3'-Parenchyma_lung-Immune_Lymphocytic-Lymphocytic_T/NK-CD8-positive,_alpha-beta_T_cell-CD8_T_cells-CD8_T_cells_L.1.1.2.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CMTM3 MAP4K1 GRK6 ZAP70

1.19e-041945849116451614431e3cf9bd7d4d626bf4bd23420e36
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_2|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

SLC6A3 TMX4 FLRT3 SLC3A1

1.19e-041945848ddcaaf24cee6e30d5be52c0cbf778cfba309c53
ToppCell10x_5'_v1-Non-neoplastic-Myeloid-TAM-MG-TAM-MG_pro-infl_II-Z|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

ABL2 TREM2 TMEM176A NRP2

1.19e-041945844cdd59b1dbeeae1c5cec11397b0eeea917c798fe
ToppCellILEUM-inflamed-(3)_Inf._Macrophages|inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

ABL2 TREM2 TMEM176A ATP13A3

1.23e-041965846ba84bc229e80b4e71c59301154d165066dd618c
ToppCellPosterior_cortex-Neuronal-Inhibitory-iN2(Gad1Gad2)-Synpr-Inhibitory_Neuron.Gad1Gad2.Synpr-Sncg_(Neuron.Gad1Gad2.Synpr-Sncg)-|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

RADX NPFFR1 CHRNA7

1.23e-0474583216721986c3055f2d9b4702be9693b3a0892283c
ToppCellPosterior_cortex-Neuronal-Inhibitory-iN2(Gad1Gad2)-Synpr-Inhibitory_Neuron.Gad1Gad2.Synpr-Sncg_(Neuron.Gad1Gad2.Synpr-Sncg)|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

RADX NPFFR1 CHRNA7

1.23e-0474583a7f7ed7316c226e18ee62d0149be7404326817c6
ToppCellCF-Myeloid-Monocyte_Macrophage|Myeloid / Disease state, Lineage and Cell class

MYOF ABL2 TMEM176A NRP2

1.26e-0419758477b150a987c0a8abe73920d93d69a590ebbbdfea
ToppCellMacrophages-HP_01|World / lung cells shred on cell class, cell subclass, sample id

CMTM3 TREM2 TRPV2 TMEM176A

1.26e-04197584598fb7a9a8400af49d90807b3155d3cc1c34f505
ToppCellsaliva-Severe-critical_progression_d12-22_no-steroids|saliva / Compartment, severity and other cell annotations on 10x 3' data (130k)

CMTM3 TREM2 TRPV2 TMEM176A

1.26e-04197584c747d05bb032abf8dad46ff6f4d1951bbe64b3b4
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Myeloid-Macrophage-macrophage,_alveolar-Macro_c1-C1QC|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

MYOF TREM2 TMEM176A NRP2

1.28e-04198584579a22199643440b98e381147779ced630d4ed66
ToppCell5'-GW_trimst-1.5-SmallIntestine-Neuronal-neurons_A-Branch_A1_(iMN)|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

NALF1 SCN5A ATP1A3 CHRFAM7A

1.28e-04198584b58138581f1a9073267d64c1211c5b9b4de71d3e
ToppCell10x_3'_v3-lymph_node_(10x_3'_v3)-myeloid-myeloid_macrophage|lymph_node_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

MYOF TREM2 TMEM176A NRP2

1.28e-04198584c08018f099a381a66993cb60288954a6e47f105f
ToppCellkidney_cells-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SBSPON TMEM176A FLRT3 SLC3A1

1.28e-04198584be305d89d48c67ce922fa71aaf15e24d00c89ff6
ToppCell10x_3'_v3-lymph_node_(10x_3'_v3)-myeloid-myeloid_macrophage-macrophage|lymph_node_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

MYOF TREM2 TMEM176A NRP2

1.28e-0419858427cc7f786fb8cb230589d762a4e51b46265c1f19
ToppCellBronchial-NucSeq-Epithelial-Epi_submucosal-gland-SMG_Duct|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

HCAR2 SLC26A8 LNX1 SLC3A1

1.28e-041985841fe60443c11d34b6d2671af8f06e0dedc8d1558b
ToppCellBronchus_Control_(B.)-Stromal-TX-Smooth_muscle-1|Bronchus_Control_(B.) / Sample group, Lineage and Cell type

SBSPON SCN5A NPFFR1 RYR2

1.28e-041985840f1feed8a37293ae02465909f99548ab58dc7ce5
ToppCellmoderate-Myeloid-Non-resident_Macrophage|Myeloid / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

ABL2 ATP13A3 ATP1A1 NRP2

1.31e-041995843895e367a33ac0316f96a64c07574de99684f4b7
ToppCellSmart-seq2-tissue-resident_(Smart-seq2)|Smart-seq2 / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

ABL2 TMEM176A ATP13A3 NRP2

1.31e-041995848be7cb9d8b4f9707efb69c681c40e683fcd810e5
ToppCellcontrol-unassigned|control / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

HCAR2 IL17RC ZAP70 LRP8

1.31e-041995845db7c8089172ac8e796613b3cef618d87007a0ab
ToppCellTracheal-10x5prime-Stromal-Schwann-Schwann_Myelinating|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

RADX SBSPON FLRT3 NPFFR1

1.31e-041995842b567b6fd8addf059bbf2b72c55a7647aefdc595
ToppCellsaliva-Severe-critical_progression_d12-22_no-steroids-Myeloid-Dendritic-conventional_dendritic_cell-DC_c2-CD1C|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

TREM2 TRPV2 TMEM176A NRP2

1.33e-042005845a3b04aaad9562636aa34750d6025e0fe0f9b2ba
ToppCellMild-Myeloid-Macrophages-FCN1-SPP1+|Mild / Condition, Lineage, Cell class and cell subclass

TREM2 TMEM176A FUCA2 NRP2

1.33e-04200584e5afd8e2cb2c63899d49fe17011f474d20bb06ea
ToppCellSigmoid-Macrophage|Sigmoid / Region, Cell class and subclass

MYOF TREM2 TMEM176A NRP2

1.33e-04200584b07ac0ff3b8530e99094678fed80f35949cafac8
ToppCellTracheal-10x3prime_v2-Epithelial|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

HCAR2 FLRT3 ATP1A1 DNAH5

1.33e-04200584e1da1b15d2ca06796ee1ab7cef586ae0b4dc0a0a
DrugNSC7524

SLC6A3 HCAR2 SCN5A ATP1A1 ATP1A3 CHRFAM7A CHRNA7 RYR2

1.95e-08182588CID000005657
Drugeuropium

SLC6A3 NPFFR2 LNX1 DNAH5 NPFFR1 RYR2

9.02e-0887586CID000023981
Drughemicholinium-3

SLC6A3 HCAR2 SLC6A16 CHRFAM7A CHRNA7

1.65e-0678585CID000003585
Drugl-Lobeline

SLC6A3 HCAR2 CHRFAM7A CHRNA7

1.66e-0634584CID000003945
Drug(+/-)-Epibatidine

SLC6A3 HCAR2 CHRFAM7A CHRNA7

1.87e-0635584CID000001204
Drugtrimethaphan

HCAR2 ATP1A1 ATP1A3 CHRFAM7A CHRNA7

1.99e-0681585CID000023576
Drugprocaine

SLC6A3 HCAR2 CACNG8 CHRFAM7A CHRNA7 RYR2

2.53e-06153586CID000004914
Drugneostigmine

HCAR2 ATP1A1 ATP1A3 CHRFAM7A CHRNA7

2.83e-0687585CID000004456
Drugpilsicainide

HCAR2 SCN5A CHRFAM7A CHRNA7

5.71e-0646584CID000004820
Drug(-)-pictamine

HCAR2 CHRFAM7A CHRNA7

6.98e-0615583CID006918623
Drug(-)-lepadin B

HCAR2 CHRFAM7A CHRNA7

6.98e-0615583CID006918624
DrugUB-165

HCAR2 CHRFAM7A CHRNA7

6.98e-0615583CID004694339
DrugAC1L2SVN

HCAR2 CHRFAM7A CHRNA7

8.58e-0616583CID000127922
Drug4-dideoxy-1,4-imino-D-xylitol

HCAR2 PRIM1 CHRFAM7A CHRNA7 LRP8 NRP2

1.05e-05196586CID000001335
Drugcyclizine

FBXO16 FMR1 TRPV2 FTO LRP8

1.16e-05116585CID000006726
DrugABT-594

HCAR2 CHRFAM7A CHRNA7

1.25e-0518583CID003075702
DrugAC1LCVGE

HCAR2 CHRFAM7A CHRNA7

1.25e-0518583CID000656712
DrugMDMA

SLC6A3 HCAR2 CHRFAM7A CHRNA7 MADD

1.43e-05121585CID000001615
DrugAC1L9P88

HCAR2 CHRFAM7A CHRNA7

1.48e-0519583CID000450860
Drugisoarecolone

HCAR2 CHRFAM7A CHRNA7

1.48e-0519583CID000146970
Drugbeta-erythroidine

HCAR2 CHRFAM7A CHRNA7

1.48e-0519583CID000010074
Drugperhydrohistrionicotoxin

HCAR2 CHRFAM7A CHRNA7

1.48e-0519583CID000107881
Drug4-(N-maleimido)benzyltrimethylammonium

HCAR2 CHRFAM7A CHRNA7

1.48e-0519583CID000162425
Drug3-(2-azetidinylmethoxy)pyridine

HCAR2 CHRFAM7A CHRNA7

1.73e-0520583CID000001962
Drugdinotefuran

HCAR2 CHRFAM7A CHRNA7

2.02e-0521583CID000197701
Drugmeproadifen

HCAR2 CHRFAM7A CHRNA7

2.02e-0521583CID000189752
Drugsuccinylcholine

HCAR2 CHRFAM7A CHRNA7 RYR2

2.15e-0564584CID000005314
DrugAR-R17779

HCAR2 CHRFAM7A CHRNA7

2.33e-0522583CID005310971
Drughistrionicotoxin

HCAR2 CHRFAM7A CHRNA7

2.33e-0522583CID005282247
Drugclothianidin

HCAR2 CHRFAM7A CHRNA7

2.33e-0522583CID000213027
Drugdisopyramide

HCAR2 SCN5A CHRFAM7A CHRNA7

2.43e-0566584CID000003114
DrugAC1L3BL8

HCAR2 CHRFAM7A CHRNA7

2.68e-0523583CID000086457
Drugalpha-conotoxin ImI

HCAR2 CHRFAM7A CHRNA7

2.68e-0523583CID000133011
DrugCID6325740

HCAR2 CHRFAM7A CHRNA7

2.68e-0523583CID006325740
DrugABT-418

HCAR2 CHRFAM7A CHRNA7

2.68e-0523583CID000119380
Drugalpha-conotoxin SI

HCAR2 CHRFAM7A CHRNA7

2.68e-0523583CID000163979
DrugSkpymrfamide

HCAR2 CHRFAM7A CHRNA7

2.68e-0523583CID000132661
DrugAC1NSKJI

HCAR2 SCN5A CHRFAM7A CHRNA7

2.73e-0568584CID005311391
Drugprocyclidine

HCAR2 CHRFAM7A CHRNA7

3.06e-0524583CID000004919
Drugintruder

HCAR2 CHRFAM7A CHRNA7

3.06e-0524583CID000213021
Druganabaseine

HCAR2 CHRFAM7A CHRNA7

3.06e-0524583CID000018985
Drugverapamil

HCAR2 CACNG8 SCN5A ATP1A1 ATP1A3 CHRFAM7A CHRNA7 RYR2

3.24e-05490588CID000002520
Drugnicardipine

HCAR2 CACNG8 CHRFAM7A CHRNA7 RYR2

3.41e-05145585CID000004473
Druganabasine

HCAR2 CHRFAM7A CHRNA7

3.47e-0525583CID000002181
Drugvarenicline

HCAR2 CHRFAM7A CHRNA7

3.47e-0525583CID000170361
Drugpempidine

HCAR2 CHRFAM7A CHRNA7

3.47e-0525583CID000006603
Drugbenzquinamide

HCAR2 CHRFAM7A CHRNA7

3.91e-0526583CID000002342
Drugbeta-eudesmol

HCAR2 CHRFAM7A CHRNA7

3.91e-0526583CID000091457
Drugcurarine

HCAR2 CHRFAM7A CHRNA7

3.91e-0526583CID000198004
Drugmethylcarbamylcholine

HCAR2 CHRFAM7A CHRNA7

4.39e-0527583CID000004136
Drugnornicotine

HCAR2 CHRFAM7A CHRNA7

4.39e-0527583CID000000412
Drugbupropion

SLC6A3 HCAR2 CHRFAM7A CHRNA7

5.45e-0581584CID000000444
Drugbifemelane

HCAR2 CHRFAM7A CHRNA7

5.47e-0529583CID000002377
Drugbromoacetylcholine bromide

HCAR2 CHRFAM7A CHRNA7

5.47e-0529583CID000204966
Drug22,23-dihydrobufalin

ATP1A1 ATP1A3

6.35e-055582CID000195392
Drug3-acetylstrophanthin

ATP1A1 ATP1A3

6.35e-055582CID003082282
Drugthevetin A

ATP1A1 ATP1A3

6.35e-055582CID000441873
Drugtetrahydrodeoxycortisol

HCAR2 CHRFAM7A CHRNA7

6.70e-0531583CID000010593
DrugAC1L1JK6

HCAR2 CHRFAM7A CHRNA7

6.70e-0531583CID000005077
DrugM3/M4

CHRFAM7A CHRNA7 RYR2

7.38e-0532583CID000486507
Drugtropicamide

HCAR2 CHRFAM7A CHRNA7

7.38e-0532583CID000005593
Drugtetracaine

HCAR2 CHRFAM7A CHRNA7 RYR2

7.54e-0588584CID000005411
Drugmecamylamine

SLC6A3 HCAR2 CHRFAM7A CHRNA7

7.88e-0589584CID000004032
Drugdecamethonium

HCAR2 CHRFAM7A CHRNA7

8.11e-0533583CID000002968
Drugmethamidophos

HCAR2 CHRFAM7A CHRNA7

8.11e-0533583CID000004096
Drugcytisine

HCAR2 CHRFAM7A CHRNA7

8.11e-0533583CID000010235
DrugGTS-21

HCAR2 CHRFAM7A CHRNA7

8.88e-0534583CID005310985
Drugthiacloprid

HCAR2 CHRFAM7A CHRNA7

8.88e-0534583CID000115224
DrugETH157

ATP1A1 ATP1A3

9.50e-056582CID000563154
Drugatracurium

HCAR2 CHRFAM7A CHRNA7

9.69e-0535583CID000047319
DrugEPTC

HCAR2 CHRFAM7A CHRNA7

9.69e-0535583CID000012968
Drugphencyclidine

SLC6A3 HCAR2 FMR1 CHRFAM7A CHRNA7

9.79e-05181585CID000006468
Drugtetradotoxin

HCAR2 SCN5A TRPV2 ATP1A1 ATP1A3 CHRFAM7A CHRNA7

1.04e-04428587CID000020382
DrugPhTX-343

HCAR2 CHRFAM7A CHRNA7

1.06e-0436583CID000159548
Drug1,2-dichlorohexafluorocyclobutane

CHRFAM7A CHRNA7 RYR2

1.15e-0437583CID000009643
DrugO585

HCAR2 CHRFAM7A CHRNA7

1.15e-0437583CID000107646
DrugNSC-293162

HCAR2 CHRFAM7A CHRNA7

1.24e-0438583CID000004675
Drugpropofol

HCAR2 TRPV2 CHRFAM7A CHRNA7 RYR2

1.26e-04191585CID000004943
Drugdihydrodigitoxigenin

ATP1A1 ATP1A3

1.33e-047582CID000107549
Drug6-Furfurylaminopurine [525-79-1]; Up 200; 18.6uM; HL60; HT_HG-U133A

SLC6A16 BEST2 MAP4K1 FLRT3 ATP1A3

1.42e-041965852511_UP
DrugDebrisoquin sulfate [581-88-4]; Up 200; 9uM; HL60; HG-U133A

ABL2 IRF2BP1 GRK6 SCN5A SNTB2

1.46e-041975851591_UP
DrugAmpicillin trihydrate [7177-48-2]; Down 200; 10uM; MCF7; HT_HG-U133A

IRF2BP1 DSTYK RYR2 SLC3A1 MADD

1.46e-041975855408_DN
DrugNitrarine dihydrochloride [20069-05-0]; Up 200; 10.6uM; PC3; HT_HG-U133A

IL17RC DIAPH3 ATP1A3 SOCS7 RYR2

1.46e-041975853683_UP
DrugChlortetracycline hydrochloride [64-72-2]; Down 200; 7.8uM; MCF7; HT_HG-U133A

MYOF IRF2BP1 NPFFR1 RYR2 SLC3A1

1.46e-041975851541_DN
Drugamiloride

CACNG8 TRPV2 ATP1A1 ATP1A3 CHRFAM7A CHRNA7

1.48e-04315586CID000016230
DrugBuflomedil hydrochloride [35543-24-9]; Up 200; 11.6uM; MCF7; HT_HG-U133A

IRF2BP1 DSTYK IL17RC NPFFR1 RYR2

1.53e-041995853274_UP
DrugChloropyramine hydrochloride [6170-42-9]; Down 200; 12.2uM; HL60; HT_HG-U133A

ADGB ABL2 MAP4K1 NPFFR1 NRP2

1.53e-041995853011_DN
Drughaloperidol; Up 200; 10uM; HL60; HT_HG-U133A

ADGB IRF2BP1 SLC6A16 MAP4K1 DSTYK

1.56e-042005852704_UP
Drugphentolamine

SLC6A3 HCAR2 ATP1A3 CHRFAM7A CHRNA7

1.56e-04200585CID000005775
Drugaspartyl-phenylalanine

NPFFR2 BEST2 GRK6 NPFFR1

1.67e-04108584CID000541493
Drugoxotremorine

HCAR2 GRK6 CHRFAM7A CHRNA7

1.67e-04108584CID000004630
DrugQX-222

HCAR2 CHRFAM7A CHRNA7

1.68e-0442583CID000005014
DrugN-methylscopolamine

HCAR2 CHRFAM7A CHRNA7

1.68e-0442583CID000004120
DrugCocaine

SLC6A3 SCN5A

1.77e-048582DB00907
Druggallamin

HCAR2 CHRFAM7A CHRNA7

1.80e-0443583CID000067425
Drugdihydro-beta-erythroidine

HCAR2 CHRFAM7A CHRNA7

1.93e-0444583CID000031762
Drugguanethidine

HCAR2 SCN5A CHRFAM7A CHRNA7

1.99e-04113584CID000003518
Drugphilanthotoxin

HCAR2 CHRFAM7A CHRNA7

2.06e-0445583CID000115201
Drug3H-diazirine

HCAR2 CHRFAM7A CHRNA7

2.06e-0445583CID000078958
Drugipratropium bromide

HCAR2 CHRFAM7A CHRNA7

2.20e-0446583CID000003746
DiseaseSchizophrenia

SLC6A3 HCAR2 SLC26A8 CACNG8 VRK2 FMR1 GRK6 ADGRF4 CHRFAM7A CHRNA7 LRP8

8.50e-078835711C0036341
Diseasealcohol use disorder (implicated_via_orthology)

MAP4K1 GRK6 ATP1A1 ATP1A3 RYR2 MADD

2.11e-06195576DOID:1574 (implicated_via_orthology)
DiseaseArrhythmogenic Right Ventricular Dysplasia

SCN5A RYR2

1.10e-053572C0349788
Diseaseneurodevelopmental disorder with regression, abnormal movements, loss of speech, and seizures (implicated_via_orthology)

IRF2BP2 IRF2BP1

1.10e-053572DOID:0081327 (implicated_via_orthology)
Diseasecognitive disorder (implicated_via_orthology)

CHRFAM7A CHRNA7

5.47e-056572DOID:1561 (implicated_via_orthology)
Diseaserheumatoid arthritis (biomarker_via_orthology)

CHRFAM7A CHRNA7

5.47e-056572DOID:7148 (biomarker_via_orthology)
Diseasefamilial hemiplegic migraine (implicated_via_orthology)

ATP1A1 ATP1A3

7.65e-057572DOID:0060178 (implicated_via_orthology)
DiseaseSenile Paranoid Dementia

SLC6A3 TREM2

1.02e-048572C0338630
DiseaseFamilial Dementia

SLC6A3 TREM2

1.02e-048572C0751071
Diseasesupraventricular ectopy

SCN5A TREM2

1.31e-049572EFO_0009277
Diseasedietary approaches to stop hypertension diet

ZSWIM6 FTO

1.31e-049572EFO_0803365
Diseaseabdominal adipose tissue measurement

ATP1A1 FTO ATP1A3

1.49e-0453573EFO_0803316
DiseaseTachycardia, Ventricular

SCN5A RYR2

1.99e-0411572C0042514
DiseaseLong QT Syndrome

SCN5A RYR2

1.99e-0411572C0023976
DiseaseSudden infant death syndrome

SCN5A CHRNA7

2.39e-0412572C0038644
Diseasenervous system disease (implicated_via_orthology)

ATP1A1 ATP1A3

2.39e-0412572DOID:863 (implicated_via_orthology)
Diseasenicotine dependence (implicated_via_orthology)

CHRFAM7A CHRNA7

2.39e-0412572DOID:0050742 (implicated_via_orthology)
Diseaseschizophrenia (implicated_via_orthology)

SLC6A3 CHRFAM7A CHRNA7

3.13e-0468573DOID:5419 (implicated_via_orthology)
Diseasecentral nervous system disease (implicated_via_orthology)

IRF2BP2 IRF2BP1

4.32e-0416572DOID:331 (implicated_via_orthology)
DiseaseDementia

SLC6A3 TREM2

4.89e-0417572C0497327
DiseaseNerve Degeneration

SLC6A3 CHRNA7 LRP8

5.63e-0483573C0027746
Diseasecolorectal cancer, hormone replacement therapy

ABL1 NALF1 LRP8

6.68e-0488573EFO_0003961, MONDO_0005575
DiseaseAnhedonia

SLC6A3 ATP1A3

9.85e-0424572C0178417
Diseaseergothioneine measurement

LNX1 DNAH5

1.16e-0326572EFO_0021163
Diseasecortical thickness

IRF2BP2 VRK2 NALF1 SMARCAL1 DIAPH3 LNX1 LRP8 NRP2

1.28e-031113578EFO_0004840
DiseaseParkinson's disease (biomarker_via_orthology)

ABL1 GRK6

1.54e-0330572DOID:14330 (biomarker_via_orthology)
Diseasefacial hair thickness measurement

FTO LNX1

1.75e-0332572EFO_0007823
Diseaseseasonal allergic rhinitis

ABL2 DNAH5

1.75e-0332572EFO_0003956
Diseasefemale fertility, fertility measurement

CMTM3 ZSWIM6

1.86e-0333572EFO_0006918, EFO_0006923

Protein segments in the cluster

PeptideGeneStartEntry
NRWWSQYLCMPLPDA

BEST2

91

Q8NFU1
PPKVYELMRACWKWS

ABL2

511

P42684
LYWMGCWRKITIDDF

ADGB

201

Q8N7X0
LLYWMPEWRVKATCV

ATP13A3

46

Q9H7F0
ILRNNPWYCGCKMKW

FLRT3

301

Q9NZU0
PWYCGCKMKWVRDWL

FLRT3

306

Q9NZU0
KGYMRPEACWLNWDN

ADGRF4

541

Q8IZF3
WLKIRPHEMTENCFW

DIAPH3

651

Q9NSV4
LNWCAWFLRMKRPGE

CHRNA7

336

P36544
YWCREDWPNQEMRKI

NPFFR2

306

Q9Y5X5
VIMWNALCPEWYKSL

RADX

276

Q6NSI4
YSCWEAWPEKGMRRV

NPFFR1

201

Q9GZQ6
QEEFQLMWCLVPWRG

NOMO2

1226

Q5JPE7
ERWWYEKLINMTYCP

MADD

1476

Q8WXG6
WDWKFGDIPCRLMLF

HCAR2

91

Q8TDS4
GNRYRKCTDWWCQPM

FTO

386

Q9C0B1
VALRMYPLKPTWWFC

ATP1A1

976

P05023
LEEPCGWMYDHAKWL

NRP2

651

O60462
PSWVMWLELPRCLYN

LNX1

621

Q8TBB1
LNWCAWFLRMKRPGE

CHRFAM7A

246

Q494W8
CWQLMEACWDGDPLK

DSTYK

881

Q6XUX3
WLEWEIMLQYCFPRL

PRIM1

291

P49642
WENCMTIDKLSWGYR

FUCA2

291

Q9BTY2
MESLKRWNEERGLWC

CACNG8

1

Q8WXS5
PCCWWLAKVRMIKGE

FMR1

76

Q06787
EKVYELMRACWQWNP

ABL1

466

P00519
KGYLRPEICWLNWDM

ADGRF2

586

Q8IZF7
VALRMYPLKPSWWFC

ATP1A3

966

P13637
LCSTGEMWYPKWRRF

GCNA

556

Q96QF7
DQLWMLKCLRFNWYI

FBXO16

126

Q8IX29
PDWWALGCLLYEMIA

GRK6

366

P43250
WKMYQERCWEFFPAG

RYR2

4941

Q92736
CYLCDLPRMPWAMIW

IRF2BP2

16

Q7Z5L9
ALDCMFDARIPAWWK

DNAH5

4431

Q8TE73
WCYLCDLPKMPWAMV

IRF2BP1

11

Q8IU81
LWACPMDKYIHKRWA

IL17RC

526

Q8NAC3
CMSGYLIWRNWKRKN

LRP8

841

Q14114
YLWLQKLWICMEFCG

MAP4K1

81

Q92918
MKPSCLWRFAYLWLN

SLC6A16

121

Q9GZN6
WLYCWRMFPTKGKRD

TMEM176A

211

Q96HP8
KLCHMYWNWPGTIRV

PIWIL2

926

Q8TC59
EWMCMYRLKDWLLGD

SLC26A8

81

Q96RN1
RYCDAKRMPWGWDYS

SMARCAL1

611

Q9NZC9
AQRYLIWECCPLWMS

SCN5A

691

Q14524
SPKCLDWWQEGPMYQ

SLC3A1

111

Q07837
DKWQGLCWPMMDFLR

CMTM3

91

Q96MX0
MEGEWMLKFYAPWCP

TMX4

51

Q9H1E5
LMSDCWIYKWEDRPD

ZAP70

571

P43403
CALENWPLTRWMQYL

SBSPON

181

Q8IVN8
MTGQRPSLYWRLCWK

SLC6A3

511

Q01959
ISVLEMENGYWWCRK

TRPV2

666

Q9Y5S1
CPYDSMKHWGRRKAW

TREM2

36

Q9NZC2
SLRELEKCGWYWGPM

SOCS7

391

O14512
KYRQLWDELGALWMC

ZSWIM6

436

Q9HCJ5
DLLLYDCMPWTRDAW

SNTB2

356

Q13425
WHLRKMDWCYEAGEP

USP40

886

Q9NVE5
LGYCMLRWLCGKLPW

VRK2

236

Q86Y07
PMRYDQWWECKFIAE

HECTD3

521

Q5T447
WMCRQYDDGLKIWLA

NALF1

6

B1AL88
MKGWWPCYAEKDGAR

MYOF

1946

Q9NZM1