Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	acyltransferase activity	RAG1 TRIM25 SH3RF1 GCAT SH3RF2 SPHK1 RNF38 PLA2G4A UBE3C HERC2 RSPRY1	6.55e-05	775	69	11	GO:0016746
GeneOntologyMolecularFunction	ubiquitin-protein transferase activity	RAG1 TRIM25 SH3RF1 SH3RF2 RNF38 UBE3C HERC2 RSPRY1	2.20e-04	473	69	8	GO:0004842
GeneOntologyMolecularFunction	ubiquitin protein ligase activity	RAG1 TRIM25 SH3RF1 SH3RF2 RNF38 UBE3C HERC2	2.94e-04	372	69	7	GO:0061630
GeneOntologyMolecularFunction	ubiquitin-like protein transferase activity	RAG1 TRIM25 SH3RF1 SH3RF2 RNF38 UBE3C HERC2 RSPRY1	3.75e-04	512	69	8	GO:0019787
GeneOntologyMolecularFunction	ubiquitin-like protein ligase activity	RAG1 TRIM25 SH3RF1 SH3RF2 RNF38 UBE3C HERC2	4.42e-04	398	69	7	GO:0061659
GeneOntologyMolecularFunction	aminoacyltransferase activity	RAG1 TRIM25 SH3RF1 SH3RF2 RNF38 UBE3C HERC2 RSPRY1	4.83e-04	532	69	8	GO:0016755
GeneOntologyMolecularFunction	phosphatidylinositol-3-phosphate binding	ATG2B PLA2G4A ATG2A	6.11e-04	48	69	3	GO:0032266
GeneOntologyMolecularFunction	extracellular matrix constituent conferring elasticity	FBN1 FBN2	7.60e-04	12	69	2	GO:0030023
GeneOntologyMolecularFunction	structural molecule activity conferring elasticity	FBN1 FBN2	1.04e-03	14	69	2	GO:0097493
GeneOntologyMolecularFunction	microtubule minus-end binding	HAUS7 TUBGCP2	1.20e-03	15	69	2	GO:0051011
GeneOntologyMolecularFunction	hormone activity	FBN1 FBN2 AVP PDYN	1.23e-03	135	69	4	GO:0005179
GeneOntologyMolecularFunction	catalytic activity, acting on DNA	ALKBH4 RAD51B RAG1 EP400 METTL4	2.12e-03	262	69	5	GO:0140097
GeneOntologyCellularComponent	phagophore	ATG2B ATG2A	3.31e-05	3	70	2	GO:0061908
GeneOntologyCellularComponent	RNA N6-methyladenosine methyltransferase complex	METTL4 VIRMA	3.92e-04	9	70	2	GO:0036396
Domain	ATG2	ATG2B ATG2A	1.38e-05	2	70	2	IPR026849
Domain	ATG2_CAD	ATG2B ATG2A	1.38e-05	2	70	2	PF13329
Domain	ATG2_CAD_motif	ATG2B ATG2A	1.38e-05	2	70	2	IPR026885
Domain	Cul7	CUL7 HERC2	4.14e-05	3	70	2	PF11515
Domain	CPH_domain	CUL7 HERC2	4.14e-05	3	70	2	IPR021097
Domain	FBN	FBN1 FBN2	4.14e-05	3	70	2	IPR011398
Domain	ATG_C	ATG2B ATG2A	1.37e-04	5	70	2	PF09333
Domain	Autophagy-rel_C	ATG2B ATG2A	1.37e-04	5	70	2	IPR015412
Domain	ARM-type_fold	CAB39 INSC CIP2A ZER1 CUL7 VIRMA RSPRY1	2.74e-04	339	70	7	IPR016024
Domain	APC_su10/DOC_dom	CUL7 HERC2	2.87e-04	7	70	2	IPR004939
Domain	TB	FBN1 FBN2	2.87e-04	7	70	2	PF00683
Domain	DOC	CUL7 HERC2	2.87e-04	7	70	2	PS51284
Domain	APC10	CUL7 HERC2	2.87e-04	7	70	2	SM01337
Domain	ANAPC10	CUL7 HERC2	2.87e-04	7	70	2	PF03256
Domain	VPS13_N	ATG2B ATG2A	3.82e-04	8	70	2	IPR026854
Domain	Chorein_N	ATG2B ATG2A	3.82e-04	8	70	2	PF12624
Domain	-	FBN1 FBN2	3.82e-04	8	70	2	3.90.290.10
Domain	Znf_C3HC4_RING-type	RAG1 TRIM25 SH3RF1 SH3RF2 RNF38	4.66e-04	172	70	5	IPR018957
Domain	TB	FBN1 FBN2	4.90e-04	9	70	2	PS51364
Domain	TB_dom	FBN1 FBN2	4.90e-04	9	70	2	IPR017878
Domain	ARM-like	CAB39 INSC CIP2A ZER1 CUL7 RSPRY1	5.22e-04	270	70	6	IPR011989
Domain	ZF_RING_1	RAG1 TRIM25 SH3RF1 SH3RF2 RNF38 RSPRY1	7.72e-04	291	70	6	PS00518
Domain	ZF_RING_2	RAG1 TRIM25 SH3RF1 SH3RF2 RNF38 RSPRY1	8.74e-04	298	70	6	PS50089
Domain	RING	RAG1 TRIM25 SH3RF1 SH3RF2 RNF38 RSPRY1	9.85e-04	305	70	6	SM00184
Domain	Znf_RING	RAG1 TRIM25 SH3RF1 SH3RF2 RNF38 RSPRY1	1.39e-03	326	70	6	IPR001841
Domain	-	CAB39 INSC CIP2A ZER1 CUL7	1.47e-03	222	70	5	1.25.10.10
Domain	zf-C3HC4	RAG1 TRIM25 SH3RF1 SH3RF2 RNF38	1.50e-03	223	70	5	PF00097
Domain	Rib_L2_dom2	CUL7 HERC2	2.04e-03	18	70	2	IPR014722
Domain	LH2	PKD1L1 ALOX12B	2.04e-03	18	70	2	SM00308
Domain	-	CUL7 HERC2	2.04e-03	18	70	2	2.30.30.30
Domain	-	CUL7 HERC2 SSPOP	2.60e-03	73	70	3	2.60.120.260
Domain	PLAT	PKD1L1 ALOX12B	2.78e-03	21	70	2	PS50095
Domain	-	PKD1L1 ALOX12B	2.78e-03	21	70	2	2.60.60.20
Domain	PLAT	PKD1L1 ALOX12B	2.78e-03	21	70	2	PF01477
Domain	PLAT/LH2_dom	PKD1L1 ALOX12B	2.78e-03	21	70	2	IPR001024
Domain	Znf_RING_CS	RAG1 TRIM25 SH3RF1 SH3RF2	3.28e-03	163	70	4	IPR017907
Domain	SH3_2	SH3TC2 SH3RF2 CASKIN1	4.13e-03	86	70	3	IPR011511
Domain	SH3_2	SH3TC2 SH3RF2 CASKIN1	4.13e-03	86	70	3	PF07653
Domain	cEGF	FBN1 FBN2	4.25e-03	26	70	2	IPR026823
Domain	cEGF	FBN1 FBN2	4.25e-03	26	70	2	PF12662
Domain	HECT	UBE3C HERC2	4.57e-03	27	70	2	PF00632
Domain	HECTc	UBE3C HERC2	4.57e-03	27	70	2	SM00119
Domain	HECT_dom	UBE3C HERC2	4.57e-03	27	70	2	IPR000569
Domain	HECT	UBE3C HERC2	4.57e-03	27	70	2	PS50237
Domain	Galactose-bd-like	CUL7 HERC2 SSPOP	5.30e-03	94	70	3	IPR008979
Domain	-	RAG1 TRIM25 SH3RF1 SH3RF2 RNF38 RSPRY1	6.69e-03	449	70	6	3.30.40.10
Domain	-	NLRC5 ZER1 XRRA1 LRRC14 LRRC30	7.07e-03	321	70	5	3.80.10.10
Domain	Znf-RING_LisH	TRIM25 SH3RF2	7.19e-03	34	70	2	IPR027370
Domain	zf-RING_UBOX	TRIM25 SH3RF2	7.19e-03	34	70	2	PF13445
Domain	Znf_RING/FYVE/PHD	RAG1 TRIM25 SH3RF1 SH3RF2 RNF38 RSPRY1	7.43e-03	459	70	6	IPR013083
Pathway	REACTOME_VASOPRESSIN_LIKE_RECEPTORS	OXTR AVP	1.76e-04	6	49	2	M27289
Pathway	REACTOME_VASOPRESSIN_LIKE_RECEPTORS	OXTR AVP	1.76e-04	6	49	2	MM14989
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	SH3TC2 SETD2 SH3RF1 UACA CIP2A LRRC14 ZFC3H1 CUL7 ZCCHC2 RSPRY1	6.38e-08	493	71	10	15368895
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	ALKBH4 SH3RF1 EP400 SPHK1 PIEZO1 CASKIN1 NLRC5 ZER1 LRRC14 ATG2A UBE3C PLEC HERC2	3.30e-07	1105	71	13	35748872
Pubmed	The human cytoplasmic dynein interactome reveals novel activators of motility.	HAUS7 FBN2 TRIM25 GCAT CIP2A PKD1L1 ATG2A UBE3C PLEC HERC2 TUBGCP2	1.21e-06	853	71	11	28718761
Pubmed	Homo- and heterotypic fibrillin-1 and -2 interactions constitute the basis for the assembly of microfibrils.	FBN1 FBN2	4.11e-06	2	71	2	12399449
Pubmed	Fibrillin-1 and fibrillin-2 are essential for formation of thick oxytalan fibers in human nonpigmented ciliary epithelial cells in vitro.	FBN1 FBN2	4.11e-06	2	71	2	21851253
Pubmed	Fibrillins can co-assemble in fibrils, but fibrillin fibril composition displays cell-specific differences.	FBN1 FBN2	4.11e-06	2	71	2	12429739
Pubmed	Atg2A/B deficiency switches cytoprotective autophagy to non-canonical caspase-8 activation and apoptosis.	ATG2B ATG2A	4.11e-06	2	71	2	28800131
Pubmed	New Evidence Supporting the Role of FBN1 in the Development of Adolescent Idiopathic Scoliosis.	FBN1 FBN2	4.11e-06	2	71	2	30044367
Pubmed	Material and mechanical properties of bones deficient for fibrillin-1 or fibrillin-2 microfibrils.	FBN1 FBN2	4.11e-06	2	71	2	21440062
Pubmed	MAGP-2 has multiple binding regions on fibrillins and has covalent periodic association with fibrillin-containing microfibrils.	FBN1 FBN2	4.11e-06	2	71	2	15131124
Pubmed	Fibrillin-1 and fibrillin-2 in human embryonic and early fetal development.	FBN1 FBN2	4.11e-06	2	71	2	12524050
Pubmed	Mammalian Atg2 proteins are essential for autophagosome formation and important for regulation of size and distribution of lipid droplets.	ATG2B ATG2A	4.11e-06	2	71	2	22219374
Pubmed	Microfibril structure masks fibrillin-2 in postnatal tissues.	FBN1 FBN2	4.11e-06	2	71	2	20404337
Pubmed	Fibrillln mutations in Marfan syndrome and related phenotypes.	FBN1 FBN2	4.11e-06	2	71	2	8791520
Pubmed	Structure and expression of fibrillin-2, a novel microfibrillar component preferentially located in elastic matrices.	FBN1 FBN2	4.11e-06	2	71	2	8120105
Pubmed	The fibrillinopathies: New insights with focus on the paradigm of opposing phenotypes for both FBN1 and FBN2.	FBN1 FBN2	4.11e-06	2	71	2	35419902
Pubmed	Fibrillin genes map to regions of conserved mouse/human synteny on mouse chromosomes 2 and 18.	FBN1 FBN2	4.11e-06	2	71	2	8307578
Pubmed	Fibrillin assembly: dimer formation mediated by amino-terminal sequences.	FBN1 FBN2	4.11e-06	2	71	2	10504303
Pubmed	Developmental expression of fibrillin genes suggests heterogeneity of extracellular microfibrils.	FBN1 FBN2	4.11e-06	2	71	2	7744963
Pubmed	Fibrillin microfibrils in bone physiology.	FBN1 FBN2	4.11e-06	2	71	2	26408953
Pubmed	Arg-Gly-Asp-containing domains of fibrillins-1 and -2 distinctly regulate lung fibroblast migration.	FBN1 FBN2	4.11e-06	2	71	2	18006876
Pubmed	Rare variants in FBN1 and FBN2 are associated with severe adolescent idiopathic scoliosis.	FBN1 FBN2	4.11e-06	2	71	2	24833718
Pubmed	Nonselective assembly of fibrillin 1 and fibrillin 2 in the rodent ocular zonule and in cultured cells: implications for Marfan syndrome.	FBN1 FBN2	4.11e-06	2	71	2	24265020
Pubmed	In vivo studies of mutant fibrillin-1 microfibrils.	FBN1 FBN2	4.11e-06	2	71	2	20529844
Pubmed	Assessing the role of SH3RF1 and SH3RF2 polymorphisms in susceptibility to tuberculosis: A case-control study in the Han Chinese population.	SH3RF1 SH3RF2	4.11e-06	2	71	2	33129950
Pubmed	Immunohistochemical expression of fibrillin-1 and fibrillin-2 during tooth development.	FBN1 FBN2	4.11e-06	2	71	2	25524144
Pubmed	Fibrillin-1 mutations causing Weill-Marchesani syndrome and acromicric and geleophysic dysplasias disrupt heparan sulfate interactions.	FBN1 FBN2	4.11e-06	2	71	2	23133647
Pubmed	Fibrillins 1 and 2 perform partially overlapping functions during aortic development.	FBN1 FBN2	4.11e-06	2	71	2	16407178
Pubmed	Linkage of Marfan syndrome and a phenotypically related disorder to two different fibrillin genes.	FBN1 FBN2	4.11e-06	2	71	2	1852206
Pubmed	Histamine- and stress-induced prolactin secretion: importance of vasopressin V1- and V2-receptors.	OXTR AVP	4.11e-06	2	71	2	7921229
Pubmed	N-terminal domains of fibrillin 1 and fibrillin 2 direct the formation of homodimers: a possible first step in microfibril assembly.	FBN1 FBN2	4.11e-06	2	71	2	10359653
Pubmed	Linkage relationships of human arginine vasopressin-neurophysin-II and oxytocin-neurophysin-I to prodynorphin and other loci on chromosome 20.	AVP PDYN	4.11e-06	2	71	2	1978246
Pubmed	Self-pMHCII complexes are variably expressed in the thymus and periphery independent of mRNA expression but dependent on the activation state of the APCs.	RAG1 SORL1	4.11e-06	2	71	2	25451972
Pubmed	Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.	SH3RF1 EP400 UACA CUL7 SSPOP	7.22e-06	130	71	5	12421765
Pubmed	RNF38 suppress growth and metastasis via ubiquitination of ACTN4 in nasopharyngeal carcinoma.	UACA RNF38 PLEC ALOX12B	8.13e-06	62	71	4	35568845
Pubmed	A conserved ATG2-GABARAP family interaction is critical for phagophore formation.	ATG2B ATG2A	1.23e-05	3	71	2	32009292
Pubmed	Interaction of tropoelastin with the amino-terminal domains of fibrillin-1 and fibrillin-2 suggests a role for the fibrillins in elastic fiber assembly.	FBN1 FBN2	1.23e-05	3	71	2	10825173
Pubmed	Sh3rf2/POSHER protein promotes cell survival by ring-mediated proteasomal degradation of the c-Jun N-terminal kinase scaffold POSH (Plenty of SH3s) protein.	SH3RF1 SH3RF2	1.23e-05	3	71	2	22128169
Pubmed	Adamts10 inactivation in mice leads to persistence of ocular microfibrils subsequent to reduced fibrillin-2 cleavage.	FBN1 FBN2	1.23e-05	3	71	2	30201140
Pubmed	An Adversarial DNA N6-Methyladenine-Sensor Network Preserves Polycomb Silencing.	ALKBH4 METTL4	1.23e-05	3	71	2	30982744
Pubmed	An attempt to identify single nucleotide polymorphisms contributing to possible relationships between personality traits and oxytocin-related genes.	OXTR AVP	1.23e-05	3	71	2	24458227
Pubmed	Pre-locus coeruleus neurons in rat and mouse.	PDYN HSD11B2	1.23e-05	3	71	2	33296280
Pubmed	Aldosterone-sensitive HSD2 neurons in mice.	PDYN HSD11B2	1.23e-05	3	71	2	30343334
Pubmed	Fibrillin-1 and -2 differentially modulate endogenous TGF-β and BMP bioavailability during bone formation.	FBN1 FBN2	1.23e-05	3	71	2	20855508
Pubmed	Latent transforming growth factor beta-binding protein 1 interacts with fibrillin and is a microfibril-associated protein.	FBN1 FBN2	2.46e-05	4	71	2	12429738
Pubmed	SETD2 Haploinsufficiency Enhances Germinal Center-Associated AICDA Somatic Hypermutation to Drive B-cell Lymphomagenesis.	RAG1 SETD2	2.46e-05	4	71	2	35443279
Pubmed	Human eye development is characterized by coordinated expression of fibrillin isoforms.	FBN1 FBN2	2.46e-05	4	71	2	25406291
Pubmed	Extracellular microfibrils control osteoblast-supported osteoclastogenesis by restricting TGF{beta} stimulation of RANKL production.	FBN1 FBN2	2.46e-05	4	71	2	20729550
Pubmed	Heparin/heparan sulfate controls fibrillin-1, -2 and -3 self-interactions in microfibril assembly.	FBN1 FBN2	2.46e-05	4	71	2	25034023
Pubmed	Comprehensive genetic analysis of relevant four genes in 49 patients with Marfan syndrome or Marfan-related phenotypes.	FBN1 FBN2	2.46e-05	4	71	2	16835936
Pubmed	Proteasome immunosubunits protect against the development of CD8 T cell-mediated autoimmune diseases.	RAG1 AVP	2.46e-05	4	71	2	21804012
Pubmed	The ubiquitin ligase TRIM25 inhibits hepatocellular carcinoma progression by targeting metastasis associated 1 protein.	TRIM25 UBE3C	2.46e-05	4	71	2	28861931
Pubmed	The indispensable role of CCR5 for in vivo suppressor function of tumor-derived CD103+ effector/memory regulatory T cells.	RAG1 ITGAE	2.46e-05	4	71	2	22664873
Pubmed	Setd2 determines distinct properties of intestinal ILC3 subsets to regulate intestinal immunity.	RAG1 SETD2	2.46e-05	4	71	2	35294891
Pubmed	Investigation of mechanism of desmopressin binding in vasopressin V2 receptor versus vasopressin V1a and oxytocin receptors: molecular dynamics simulation of the agonist-bound state in the membrane-aqueous system.	OXTR AVP	2.46e-05	4	71	2	16333859
Pubmed	Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.	SETD2 SH3RF1 EP400 CIP2A CUL7 TUBGCP2 ZCCHC2 SORL1	2.66e-05	588	71	8	38580884
Pubmed	VCP phosphorylation-dependent interaction partners prevent apoptosis in Helicobacter pylori-infected gastric epithelial cells.	CAB39 TRIM25 CIP2A PLEC CUL7 TUBGCP2	2.79e-05	288	71	6	23383273
Pubmed	Characterization of Microfibrillar-associated Protein 4 (MFAP4) as a Tropoelastin- and Fibrillin-binding Protein Involved in Elastic Fiber Formation.	FBN1 FBN2	4.09e-05	5	71	2	26601954
Pubmed	Oxytocin-Gly-Lys-Arg: a novel cardiomyogenic peptide.	OXTR AVP	4.09e-05	5	71	2	21048978
Pubmed	Pro-Survival Lipid Sphingosine-1-Phosphate Metabolically Programs T Cells to Limit Anti-tumor Activity.	RAG1 SPHK1	4.09e-05	5	71	2	31412253
Pubmed	Relaxin regulates fibrillin 2, but not fibrillin 1, mRNA and protein expression by human dermal fibroblasts and murine fetal skin.	FBN1 FBN2	4.09e-05	5	71	2	12590922
Pubmed	Macrophage autophagy in immunity to Cryptococcus neoformans and Candida albicans.	ATG2B ATG2A	4.09e-05	5	71	2	22710871
Pubmed	Podoplanin maintains high endothelial venule integrity by interacting with platelet CLEC-2.	RAG1 SPHK1	4.09e-05	5	71	2	23995678
Pubmed	The dichotomous pattern of IL-12r and IL-23R expression elucidates the role of IL-12 and IL-23 in inflammation.	RAG1 IL12RB1	4.09e-05	5	71	2	24586521
Pubmed	Fibrillin-1 interactions with fibulins depend on the first hybrid domain and provide an adaptor function to tropoelastin.	FBN1 FBN2	4.09e-05	5	71	2	17255108
Pubmed	POGLUT2 and POGLUT3 O-glucosylate multiple EGF repeats in fibrillin-1, -2, and LTBP1 and promote secretion of fibrillin-1.	FBN1 FBN2	4.09e-05	5	71	2	34411563
Pubmed	The function of Wtap in N6-adenosine methylation of mRNAs controls T cell receptor signaling and survival of T cells.	RAG1 VIRMA	4.09e-05	5	71	2	35879451
Pubmed	Toxoplasma gondii profilin promotes recruitment of Ly6Chi CCR2+ inflammatory monocytes that can confer resistance to bacterial infection.	RAG1 IL12RB1	4.09e-05	5	71	2	24945711
Pubmed	Development, composition, and structural arrangements of the ciliary zonule of the mouse.	FBN1 FBN2	4.09e-05	5	71	2	23493297
Pubmed	Foxp3-expressing CD103+ regulatory T cells accumulate in dendritic cell aggregates of the colonic mucosa in murine transfer colitis.	RAG1 ITGAE	4.09e-05	5	71	2	16723705
Pubmed	Activity-based E3 ligase profiling uncovers an E3 ligase with esterification activity.	TRIM25 UBE3C HERC2 RSPRY1	4.41e-05	95	71	4	29643511
Pubmed	Comparative interactome analysis of α-arrestin families in human and Drosophila.	TRIM25 UBE3C CUL7 HERC2 TUBGCP2 ZCCHC2	4.44e-05	313	71	6	38270169
Pubmed	Biased Oxytocinergic Modulation of Midbrain Dopamine Systems.	OXTR AVP	6.13e-05	6	71	2	28669546
Pubmed	Deletion of Vβ3+CD4+ T cells by endogenous mouse mammary tumor virus 3 prevents type 1 diabetes induction by autoreactive CD8+ T cells.	RAG1 SPHK1	6.13e-05	6	71	2	38015847
Pubmed	Of mice and Marfan: genetic linkage analyses of the fibrillin genes, Fbn1 and Fbn2, in the mouse genome.	FBN1 FBN2	6.13e-05	6	71	2	7873879
Pubmed	Gating of social reward by oxytocin in the ventral tegmental area.	OXTR AVP	6.13e-05	6	71	2	28963257
Pubmed	Goblet cells deliver luminal antigen to CD103+ dendritic cells in the small intestine.	RAG1 ITGAE	6.13e-05	6	71	2	22422267
Pubmed	The deubiquitinase TRABID stabilizes the K29/K48-specific E3 ubiquitin ligase HECTD1.	TRIM25 UBE3C ZFC3H1 CUL7 HERC2	7.54e-05	212	71	5	33853758
Pubmed	Regulation of limb patterning by extracellular microfibrils.	FBN1 FBN2	8.57e-05	7	71	2	11470817
Pubmed	Putative functions of extracellular matrix glycoproteins in secondary palate morphogenesis.	FBN1 FBN2	1.14e-04	8	71	2	23055981
Pubmed	Adamts17 is involved in skeletogenesis through modulation of BMP-Smad1/5/8 pathway.	FBN1 FBN2	1.14e-04	8	71	2	31201465
Pubmed	IFN-λ Enhances Constitutive Expression of MHC Class I Molecules on Thymic Epithelial Cells.	RAG1 NLRC5	1.14e-04	8	71	2	32690660
Pubmed	Common quantitative trait loci for alcohol-related behaviors and central nervous system neurotensin measures: hypnotic and hypothermic effects.	AVP PDYN	1.14e-04	8	71	2	9023306
Pubmed	An airway-to-brain sensory pathway mediates influenza-induced sickness.	OXTR PDYN	1.14e-04	8	71	2	36890237
Pubmed	Targeting of bone morphogenetic protein growth factor complexes to fibrillin.	FBN1 FBN2	1.14e-04	8	71	2	18339631
Pubmed	Microfibril-associated glycoprotein-2 interacts with fibrillin-1 and fibrillin-2 suggesting a role for MAGP-2 in elastic fiber assembly.	FBN1 FBN2	1.47e-04	9	71	2	12122015
Pubmed	An excitatory paraventricular nucleus to AgRP neuron circuit that drives hunger.	AVP PDYN	1.47e-04	9	71	2	24487620
Pubmed	The composition and signaling of the IL-35 receptor are unconventional.	RAG1 IL12RB1	1.47e-04	9	71	2	22306691
Pubmed	Poglut2/3 double knockout in mice results in neonatal lethality with reduced levels of fibrillin in lung tissues.	FBN1 FBN2	1.47e-04	9	71	2	38844137
Pubmed	Regional and cell-type-specific afferent and efferent projections of the mouse claustrum.	OXTR AVP PDYN	1.49e-04	50	71	3	36774552
Pubmed	Limb- and tendon-specific Adamtsl2 deletion identifies a role for ADAMTSL2 in tendon growth in a mouse model for geleophysic dysplasia.	FBN1 FBN2	1.83e-04	10	71	2	30738849
Pubmed	Long noncoding RNA DLGAP1-AS2 promotes tumorigenesis and metastasis by regulating the Trim21/ELOA/LHPP axis in colorectal cancer.	TRIM25 UBE3C	1.83e-04	10	71	2	36376892
Pubmed	The Paraventricular Hypothalamus Regulates Satiety and Prevents Obesity via Two Genetically Distinct Circuits.	AVP PDYN	1.83e-04	10	71	2	30879785
Pubmed	Poly r(C) binding protein (PCBP) 1 expression is regulated by the E3 ligase UBE4A in thyroid carcinoma.	TRIM25 UBE3C	2.23e-04	11	71	2	28963376
Pubmed	Bone morphogenetic protein (BMP) 7 expression is regulated by the E3 ligase UBE4A in diabetic nephropathy.	TRIM25 UBE3C	2.23e-04	11	71	2	30663414
Pubmed	A distinct transcriptome characterizes neural crest-derived cells at the migratory wavefront during enteric nervous system development.	FBN1 FBN2	2.68e-04	12	71	2	36779913
Pubmed	Disruption of murine Adamtsl4 results in zonular fiber detachment from the lens and in retinal pigment epithelium dedifferentiation.	FBN1 FBN2	2.68e-04	12	71	2	26405179
Pubmed	Genome-wide siRNA screen reveals amino acid starvation-induced autophagy requires SCOC and WAC.	RASIP1 NRBP2	3.68e-04	14	71	2	22354037
Pubmed	The ubiquitin ligase TRIM25 targets ERG for degradation in prostate cancer.	TRIM25 HERC2	3.68e-04	14	71	2	27626314
Pubmed	Local anesthetics impair the growth and self-renewal of glioblastoma stem cells by inhibiting ZDHHC15-mediated GP130 palmitoylation.	FBN1 FBN2 SSPOP	4.22e-04	71	71	3	33541421
Interaction	ZFP41 interactions	FBN1 FBN2 TRIM25 VIRMA SORL1	1.10e-06	57	65	5	int:ZFP41
Interaction	ATG2A interactions	TRIM25 ATG2B ATG2A VIRMA	1.33e-05	45	65	4	int:ATG2A
Interaction	RNF38 interactions	TRIM25 UACA RNF38 PLEC ALOX12B	1.95e-05	102	65	5	int:RNF38
Interaction	MTRNR2L8 interactions	TRIM25 VIRMA	3.07e-05	3	65	2	int:MTRNR2L8
Interaction	RN7SL3 interactions	TRIM25 VIRMA	3.07e-05	3	65	2	int:RN7SL3
Interaction	SMG1P2 interactions	TRIM25 VIRMA	3.07e-05	3	65	2	int:SMG1P2
Interaction	SMG1P3 interactions	TRIM25 VIRMA	3.07e-05	3	65	2	int:SMG1P3
Interaction	THRIL interactions	TRIM25 VIRMA	3.07e-05	3	65	2	int:THRIL
Interaction	PRR14L interactions	TRIM25 ALDH16A1 HERC2 VIRMA	3.93e-05	59	65	4	int:PRR14L
Interaction	SLC7A5P2 interactions	TRIM25 VIRMA	6.12e-05	4	65	2	int:SLC7A5P2
Interaction	MIRLET7BHG interactions	TRIM25 VIRMA	6.12e-05	4	65	2	int:MIRLET7BHG
Interaction	NTN5 interactions	FBN1 FBN2 SORL1	6.18e-05	24	65	3	int:NTN5
Interaction	UBE2D2 interactions	RAG1 TRIM25 RNF38 UBE3C PLEC HERC2 RSPRY1	7.25e-05	318	65	7	int:UBE2D2
Interaction	PTPRM interactions	TRIM25 CIP2A UBE3C VIRMA	8.60e-05	72	65	4	int:PTPRM
Interaction	FEZF1 interactions	CUL7 HERC2 SORL1	9.90e-05	28	65	3	int:FEZF1
Interaction	SRD5A1 interactions	TRIM25 CUL7	1.02e-04	5	65	2	int:SRD5A1
Interaction	HOOK1 interactions	FBN2 ATG2A UBE3C PLEC HERC2 VIRMA	1.23e-04	240	65	6	int:HOOK1
Cytoband	5q23-q31	FBN2 NEUROG1	2.36e-06	2	71	2	5q23-q31
Cytoband	8q24	PLEC HHLA1	8.68e-04	28	71	2	8q24
Cytoband	16q13	NLRC5 RSPRY1	1.44e-03	36	71	2	16q13
Cytoband	Ensembl 112 genes in cytogenetic band chr16q13	NLRC5 RSPRY1	1.77e-03	40	71	2	chr16q13
Cytoband	Ensembl 112 genes in cytogenetic band chr8q24	NRBP2 LRRC14 PLEC HHLA1	2.27e-03	355	71	4	chr8q24
Cytoband	11q13.2	KMT5B NUDT8	2.44e-03	47	71	2	11q13.2
Cytoband	16q24.3	CTU2 PIEZO1	2.97e-03	52	71	2	16q24.3
Cytoband	5q32	SH3TC2 SH3RF2	3.20e-03	54	71	2	5q32
Cytoband	2q37.1	CAB39 DIS3L2	4.89e-03	67	71	2	2q37.1
Cytoband	Ensembl 112 genes in cytogenetic band chr11q13	KMT5B XRRA1 ATG2A NUDT8	5.44e-03	454	71	4	chr11q13
GeneFamily	Ring finger proteins	RAG1 TRIM25 SH3RF1 SH3RF2 RNF38 RSPRY1	6.59e-05	275	46	6	58
GeneFamily	Autophagy related	ATG2B ATG2A	3.18e-03	33	46	2	1022
GeneFamily	Zinc fingers C2H2-type\|Lysine methyltransferases\|PR/SET domain family	SETD2 KMT5B	3.37e-03	34	46	2	487
Coexpression	WILCOX_RESPONSE_TO_PROGESTERONE_DN	OXTR PCDHGA1 PIEZO1 PLEC HSD11B2	6.28e-07	62	69	5	M16774
ToppCell	primary_visual_cortex-Non-neuronal-oligodendrocyte-Oligo-Oligo_Synpr\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	IL12RB1 SH3TC2 INSC PLA2G4A SSPOP	2.25e-06	134	70	5	3dd4b5eddc94c1d49ab23b287ee234db3a55331b
ToppCell	Calu_3-infected\|Calu_3 / Cell line, Condition and Strain	SETD2 TRANK1 TRIM25 NLRC5 ZCCHC2	1.03e-05	183	70	5	8f7f5000645f24f20a8d7700c4df1f8953a1780b
ToppCell	droplet-Heart-HEART_(ALL_MINUS_AORTA)-30m\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FBN1 SPHK1 PLA2G4A PLEC HAS1	1.20e-05	189	70	5	562f8bf5a7d38afb4a8f2415d617d5f79cfb7e3f
ToppCell	droplet-Heart-HEART_(ALL_MINUS_AORTA)\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FBN1 SPHK1 PLA2G4A PLEC HAS1	1.20e-05	189	70	5	270dd4a0fc5260288fe6829837942c78b40ecec4
ToppCell	Control-Control-Lymphocyte-T/NK-CD4+_T_activated\|Control / Disease, condition lineage and cell class	TRANK1 NLRC5 CACNA1I ZCCHC2 SORL1	1.51e-05	198	70	5	ee71543559836fd59adc0da877b2ca538cba60cb
Drug	Mcppa-avp	OXTR AVP PDYN HSD11B2	2.24e-06	30	71	4	CID000105077
Disease	connective tissue disease (implicated_via_orthology)	FBN1 FBN2	1.66e-05	3	70	2	DOID:65 (implicated_via_orthology)
Disease	scoliosis (is_implicated_in)	FBN1 FBN2	3.32e-05	4	70	2	DOID:0060249 (is_implicated_in)
Disease	Schizoaffective Disorder	NEUROG1 AVP PLA2G4A	4.47e-05	29	70	3	C0036337
Disease	Asthma, Occupational	PLA2G4A HERC2	2.47e-04	10	70	2	C0264423
Disease	breastfeeding duration	FBN2 ZCCHC2	4.96e-04	14	70	2	EFO_0006864
Disease	lymphocyte count	IPPK RAD51B SH3TC2 SETD2 FBN1 PCDHGB1 SPHK1 PCDHGA1 PIEZO1 NLRC5 PLEC	6.30e-04	1464	70	11	EFO_0004587
Disease	Amnesia	AVP PDYN	7.37e-04	17	70	2	C0002622
Disease	Tactile Amnesia	AVP PDYN	7.37e-04	17	70	2	C0750906
Disease	Amnestic State	AVP PDYN	7.37e-04	17	70	2	C0750907
Disease	Dissociative Amnesia	AVP PDYN	7.37e-04	17	70	2	C0236795
Disease	hyperglycemia (implicated_via_orthology)	AVP PLA2G4A	7.37e-04	17	70	2	DOID:4195 (implicated_via_orthology)
Disease	Global Amnesia	AVP PDYN	7.37e-04	17	70	2	C0262497
Disease	Hysterical amnesia	AVP PDYN	7.37e-04	17	70	2	C0233750
Disease	Temporary Amnesia	AVP PDYN	7.37e-04	17	70	2	C0233796
Disease	Sarcosine measurement	PCDHGB1 PCDHGA1	1.36e-03	23	70	2	EFO_0021668
Disease	osteoarthritis, hip	PIEZO1 PLEC HERC2	1.38e-03	92	70	3	EFO_1000786
Disease	mental development measurement	PCDHGB1 PCDHGA1	1.61e-03	25	70	2	EFO_0008230
Disease	hypertension (biomarker_via_orthology)	FBN1 OXTR AVP HSD11B2	2.10e-03	227	70	4	DOID:10763 (biomarker_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
LSMCREAPGSLLLCS	ALKBH4	191	Q9NXW9
SSESPSELMLTLCRC	EP400	1806	Q96L91
SELMLTLCRCGESLQ	EP400	1811	Q96L91
SAACPLLALEVCQDM	ALDH16A1	696	Q8IZ83
CLKMNPDDRLTCSQL	CDKL4	266	Q5MAI5
SPEIALNCGIMLREC	CAB39	136	Q9Y376
LMSELTDDCACVPEL	CRYGA	101	P11844
TCCSPRLRLLQMDLT	HSD11B2	126	P80365
RLLCEELCSLNPMSD	DIS3L2	446	Q8IYB7
CCLRVSLMPLRLNVD	ATG2A	1576	Q2TAZ0
QECCLRVSLMPLRLN	ATG2B	1696	Q96BY7
SELCCKPLCLMLADE	RAG1	651	P15918
TCQDFLCLSPLELMK	RAD51B	26	O15315
PQLCNDLELCDEAMA	RASIP1	676	Q5U651
KDCSIMIALSPCLQD	IPPK	401	Q9H8X2
MLPDCLSAEGELRCR	NUDT8	1	Q8WV74
LLLSSNMCAALLEPR	CASKIN1	166	Q8WXD9
DPNMREFILCCLARD	NRBP2	276	Q9NSY0
MPARLETCISDLDCA	NEUROG1	1	Q92886
KELLSDRCVLSCPSM	HERC2	3716	O95714
SCPSMDLVTCLLDFR	HERC2	3726	O95714
CCSDPLSLLESRMEV	KMT5B	801	Q4FZB7
LCEDLLLMPTEGELC	ITGAE	761	P38570
MCDLNPLLNLACTDT	OR4C46	176	A6NHA9
LLCDDPSMVVCASNE	PCDHGB1	776	Q9Y5G3
CLLMFPSTTADCLSR	PDYN	11	P01213
CMACLRSPNTDREVL	CUL7	711	Q14999
DTCLKDCMLTNPELL	TUBGCP2	731	Q9BSJ2
SMDGDIAPLQEICCL	GCAT	206	O75600
LLMSLDRCLAICQPL	OXTR	131	P30559
CLARMEPLLSQALSC	IQSEC3	1106	Q9UPP2
CMELPLLRQIDLVSC	NLRC5	1736	Q86WI3
FMCDILPLLELSCNS	OR8B12	176	Q8NGG6
CMDIDECQRDPLLCR	FBN1	1111	P35555
PCDDMDCLSDRCKIL	CACNA1I	101	Q9P0X4
LMLCAPDDQELLKGC	HAUS7	106	Q99871
CDSDTRLDPMALLEL	HAS1	236	Q92839
AEAFCLALLRNLPMC	ALOX12B	406	O75342
DDTESCLCPLEMNVA	IL12RB1	191	P42701
SCMSRLIELCRSPSE	INSC	511	Q1MX18
CMDIDECERNPLLCR	FBN2	1156	P35556
ELSLQAMCEDCSEIP	PKD1L1	911	Q8TDX9
PRCLLCMCALDVDAA	CTU2	386	Q2VPK5
LPLDACSLSELCEMA	METTL4	191	Q8N3J2
MNCLTEVPAELSLCR	LRRC30	126	A6NM36
DREELCAQSMPCLVS	PCDHGA1	91	Q9Y5H4
LEVCSCPDLRFSMAL	PLA2G4A	136	P47712
TLAIQRLNPCLMELC	HHLA1	456	C9JL84
MSDERNCPTTICDLD	SORL1	1106	Q92673
CMCDFESRQLLRVLP	RNF38	466	Q9H0F5
DLCMDCALQLETCPL	RSPRY1	546	Q96DX4
RLCLANCTMGDPLQE	SSPOP	3911	A2VEC9
DEISILSPLSQCCMI	FAM20A	441	Q96MK3
ACPMLRQALAACEEL	SH3TC2	736	Q8TF17
DCIPLMSILCSDTNE	OR8K1	186	Q8NGG5
MDESALLDLLECPVC	SH3RF1	1	Q7Z6J0
DELKMPCLGLLANLC	CIP2A	156	Q8TCG1
RLEFMCGLLDLCNPL	ZCCHC2	111	Q9C0B9
PESLMALCTDFCLRN	ZER1	6	Q7Z7L7
MAELCPLAEELSCSI	TRIM25	1	Q14258
CDLASCQSTRPMLET	SOGA1	366	O94964
RAMSDLELRQCLPCG	AVP	31	P01185
LMERCITDPQTGLCL	PLEC	4241	Q15149
LNRLLMIECSSRCPN	SETD2	1521	Q9BYW2
AAMADCPSSIQLLCD	UACA	141	Q9BZF9
MDDLTLLDLLECPVC	SH3RF2	1	Q8TEC5
TNCTLLLCRRLLSPM	SPHK1	136	Q9NYA1
IELQECRTDCNLLPM	PIEZO1	2406	Q92508
PCSLRDCLMQDITVL	TRANK1	681	O15050
MLRRICVQLCDLASP	VIRMA	1176	Q69YN4
SLPNKELMTSICDCL	VIRMA	1316	Q69YN4
AMELCKSLLESCPIN	ZFC3H1	1621	O60293
ETLMLDDNRLSNPSC	XRRA1	231	Q6P2D8
DLERLPTASTCMNLL	UBE3C	1041	Q15386
CCRDLRAEDLPMRNT	LRRC14	196	Q15048