Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionG protein-coupled receptor activity

OR2L8 OR5M9 GPR20 OR2L3 OR5AK2 OR11H7 OR1S2 P2RY8 VN1R17P OR5M3 OR5M8 GABBR2 GRM4 OR1D2 OR6C75 OR52E1 OR1E3 GPR156 CMKLR1 OR8D4 PTGDR2

1.78e-098849921GO:0004930
GeneOntologyMolecularFunctiontransmembrane signaling receptor activity

OR2L8 OR5M9 GPR20 OR2L3 OR5AK2 OR11H7 OR1S2 P2RY8 VN1R17P OR5M3 OR5M8 GABBR2 CR1 GRM4 OR1D2 LYVE1 OR6C75 CLEC2D OR52E1 OR1E3 GPR156 CMKLR1 OR8D4 PTGDR2

3.13e-0813539924GO:0004888
GeneOntologyMolecularFunctionolfactory receptor activity

OR2L8 OR5M9 OR2L3 OR5AK2 OR11H7 OR1S2 OR5M3 OR5M8 OR1D2 OR6C75 OR52E1 OR1E3 OR8D4

2.12e-074319913GO:0004984
GeneOntologyMolecularFunctionactive transmembrane transporter activity

SLC46A2 SLC22A11 SLC28A3 ABCA9 SLC6A7 SLC9B1 ATP2C1 CLCN6 SLC16A5 COX5A ATP2B3 SLC16A8

4.23e-064779912GO:0022804
GeneOntologyMolecularFunctiontransporter activity

SLC46A2 TRPM4 SLC22A11 SLC28A3 ATP10B APOB OTOP3 ABCA9 ATP10D SLC2A5 SLC6A7 SLC9B1 ATP2C1 CLCN6 SLC16A5 COX5A KCNMB1 ATP2B3 SLC16A8

1.62e-0512899919GO:0005215
GeneOntologyMolecularFunctionglycosylceramide flippase activity

ATP10B ATP10D

7.28e-053992GO:0140351
GeneOntologyMolecularFunctionG protein-coupled GABA receptor activity

GABBR2 GPR156

7.28e-053992GO:0004965
GeneOntologyMolecularFunctionsecondary active transmembrane transporter activity

SLC46A2 SLC22A11 SLC28A3 SLC6A7 SLC9B1 CLCN6 SLC16A5 SLC16A8

1.13e-04296998GO:0015291
GeneOntologyMolecularFunctioncalmodulin binding

MYH1 TRPM4 MYH3 MYH8 PDE1B GRM4 ATP2B3

1.49e-04230997GO:0005516
GeneOntologyMolecularFunctiontransmembrane transporter activity

SLC46A2 TRPM4 SLC22A11 SLC28A3 OTOP3 ABCA9 SLC2A5 SLC6A7 SLC9B1 ATP2C1 CLCN6 SLC16A5 COX5A KCNMB1 ATP2B3 SLC16A8

2.17e-0411809916GO:0022857
GeneOntologyMolecularFunctionATP hydrolysis activity

MYH3 MYH8 PSMC2 ATP10B ABCA9 ATP10D ATP2C1 ATP2B3 KIF25

3.45e-04441999GO:0016887
GeneOntologyMolecularFunctionodorant binding

OR5M9 OR5AK2 OR5M3 OR5M8 OR8D4

4.27e-04127995GO:0005549
GeneOntologyMolecularFunctionmyosin phosphatase activity

MYH3 MYH8 DUSP29 PPTC7

8.46e-0485994GO:0017018
GeneOntologyMolecularFunctionmicrofilament motor activity

MYH1 MYH3 MYH8

8.79e-0438993GO:0000146
GeneOntologyMolecularFunctionsymporter activity

SLC46A2 SLC28A3 SLC6A7 SLC16A5 SLC16A8

9.08e-04150995GO:0015293
GeneOntologyMolecularFunctionATP-dependent activity

MYH1 MYH3 MYH8 PSMC2 ATP10B ABCA9 ATP10D ATP2C1 ATP2B3 KIF25

9.38e-046149910GO:0140657
GeneOntologyMolecularFunctionP-type calcium transporter activity

ATP2C1 ATP2B3

1.30e-0311992GO:0005388
GeneOntologyMolecularFunctioninorganic molecular entity transmembrane transporter activity

TRPM4 SLC22A11 SLC28A3 OTOP3 SLC6A7 SLC9B1 ATP2C1 CLCN6 COX5A KCNMB1 ATP2B3

1.33e-037589911GO:0015318
GeneOntologyMolecularFunctionprotein serine/threonine phosphatase activity

MYH3 MYH8 DUSP29 PPTC7

2.12e-03109994GO:0004722
GeneOntologyMolecularFunctioncomplement receptor activity

CR1 CMKLR1

2.13e-0314992GO:0004875
GeneOntologyBiologicalProcessG protein-coupled receptor signaling pathway

OR2L8 OR5M9 GPR20 OR2L3 OR5AK2 OR11H7 OR1S2 P2RY8 VN1R17P DGKH OR5M3 OR5M8 GABBR2 GRM4 OR1D2 THPO OR6C75 OR52E1 OR1E3 GPR156 CMKLR1 BCAR3 OR8D4 PTGDR2

3.03e-0813959924GO:0007186
GeneOntologyBiologicalProcessdetection of chemical stimulus involved in sensory perception of smell

OR2L8 OR5M9 OR2L3 OR5AK2 OR11H7 OR1S2 OR5M3 OR5M8 OR1D2 OR6C75 OR52E1 OR1E3 OR8D4

1.51e-074329913GO:0050911
GeneOntologyBiologicalProcessdetection of chemical stimulus

OR2L8 OR5M9 OR2L3 OR5AK2 OR11H7 OR1S2 OR5M3 OR5M8 OR1D2 OR6C75 OR52E1 KCNMB1 OR1E3 OR8D4

2.06e-075249914GO:0009593
GeneOntologyBiologicalProcesssensory perception of chemical stimulus

OR2L8 OR5M9 OR2L3 OR5AK2 OR11H7 OR1S2 VN1R17P OR5M3 OR5M8 OR1D2 OR6C75 OR52E1 OR1E3 OR8D4

3.47e-075479914GO:0007606
GeneOntologyBiologicalProcesssensory perception of smell

OR2L8 OR5M9 OR2L3 OR5AK2 OR11H7 OR1S2 OR5M3 OR5M8 OR1D2 OR6C75 OR52E1 OR1E3 OR8D4

3.49e-074659913GO:0007608
GeneOntologyBiologicalProcessdetection of chemical stimulus involved in sensory perception

OR2L8 OR5M9 OR2L3 OR5AK2 OR11H7 OR1S2 OR5M3 OR5M8 OR1D2 OR6C75 OR52E1 OR1E3 OR8D4

5.62e-074859913GO:0050907
GeneOntologyBiologicalProcessdetection of stimulus involved in sensory perception

OR2L8 OR5M9 OR2L3 OR5AK2 OR11H7 OR1S2 OR5M3 OR5M8 OR1D2 OR6C75 OR52E1 OR1E3 OR8D4

4.22e-065829913GO:0050906
GeneOntologyBiologicalProcessdetection of stimulus

OR2L8 OR5M9 OR2L3 OR5AK2 OR11H7 OR1S2 OR5M3 OR5M8 OR1D2 OR6C75 OR52E1 KCNMB1 OR1E3 OR8D4

8.86e-067229914GO:0051606
GeneOntologyBiologicalProcesssensory perception

OR2L8 OR5M9 OR2L3 OR5AK2 OR11H7 OR1S2 VN1R17P OR5M3 OR5M8 OR1D2 LRIG2 OR6C75 OR52E1 OR1E3 OR8D4

1.76e-0410729915GO:0007600
GeneOntologyCellularComponentmuscle myosin complex

MYH1 MYH3 MYH8

5.52e-0516993GO:0005859
GeneOntologyCellularComponentG protein-coupled receptor heterodimeric complex

GABBR2 GPR156

6.64e-053992GO:0038039
GeneOntologyCellularComponentmyosin filament

MYH1 MYH3 MYH8

2.20e-0425993GO:0032982
GeneOntologyCellularComponentmyosin II complex

MYH1 MYH3 MYH8

3.10e-0428993GO:0016460
GeneOntologyCellularComponentG protein-coupled receptor dimeric complex

GABBR2 GPR156

4.59e-047992GO:0038037
GeneOntologyCellularComponentG protein-coupled receptor complex

GABBR2 GPR156

1.19e-0311992GO:0097648
DomainGPCR_Rhodpsn_7TM

OR2L8 OR5M9 GPR20 OR2L3 OR5AK2 OR1S2 P2RY8 OR5M3 OR5M8 OR1D2 OR6C75 CMKLR1 OR8D4 PTGDR2

5.52e-066709314IPR017452
Domain7tm_1

OR2L8 OR5M9 GPR20 OR2L3 OR5AK2 OR1S2 P2RY8 OR5M3 OR5M8 OR1D2 OR6C75 CMKLR1 OR8D4 PTGDR2

6.21e-066779314PF00001
DomainG_PROTEIN_RECEP_F1_1

OR2L8 OR5M9 GPR20 OR2L3 OR5AK2 OR1S2 P2RY8 OR5M3 OR5M8 OR1D2 OR6C75 CMKLR1 OR8D4 PTGDR2

7.10e-066859314PS00237
DomainG_PROTEIN_RECEP_F1_2

OR2L8 OR5M9 GPR20 OR2L3 OR5AK2 OR1S2 P2RY8 OR5M3 OR5M8 OR1D2 OR6C75 CMKLR1 OR8D4 PTGDR2

7.84e-066919314PS50262
DomainGPCR_Rhodpsn

OR2L8 OR5M9 GPR20 OR2L3 OR5AK2 OR1S2 P2RY8 OR5M3 OR5M8 OR1D2 OR6C75 CMKLR1 OR8D4 PTGDR2

7.97e-066929314IPR000276
DomainHydrolase_3

ATP10B ATP10D ATP2B3

1.40e-0510933PF08282
DomainOlfact_rcpt

OR2L8 OR5M9 OR2L3 OR5AK2 OR1S2 OR5M3 OR5M8 OR1D2 OR6C75 OR8D4

2.59e-053939310IPR000725
DomainP_typ_ATPase

ATP10B ATP10D ATP2C1 ATP2B3

3.00e-0536934IPR001757
DomainATPase_P-typ_P_site

ATP10B ATP10D ATP2C1 ATP2B3

3.00e-0536934IPR018303
DomainATPASE_E1_E2

ATP10B ATP10D ATP2C1 ATP2B3

3.00e-0536934PS00154
DomainATPase_P-typ_transduc_dom_A

ATP10B ATP10D ATP2C1 ATP2B3

3.35e-0537934IPR008250
DomainE1-E2_ATPase

ATP10B ATP10D ATP2C1 ATP2B3

3.35e-0537934PF00122
DomainMyosin_N

MYH1 MYH3 MYH8

5.21e-0515933PF02736
DomainMyosin_N

MYH1 MYH3 MYH8

5.21e-0515933IPR004009
DomainGPCR3_GABA-B

GABBR2 GPR156

7.33e-053932IPR002455
DomainMyosin_tail_1

MYH1 MYH3 MYH8

9.24e-0518933PF01576
DomainMyosin_tail

MYH1 MYH3 MYH8

9.24e-0518933IPR002928
DomainMyosin-like_IQ_dom

MYH1 MYH3 MYH8

1.09e-0419933IPR027401
Domain-

MYH1 MYH3 MYH8

1.09e-04199334.10.270.10
DomainGPCR_3

GABBR2 GRM4 GPR156

1.49e-0421933IPR000337
Domain7tm_3

GABBR2 GRM4 GPR156

1.72e-0422933PF00003
DomainG_PROTEIN_RECEP_F3_2

GABBR2 GRM4 GPR156

1.72e-0422933PS00980
DomainG_PROTEIN_RECEP_F3_3

GABBR2 GRM4 GPR156

1.72e-0422933PS00981
DomainG_PROTEIN_RECEP_F3_1

GABBR2 GRM4 GPR156

1.72e-0422933PS00979
DomainG_PROTEIN_RECEP_F3_4

GABBR2 GRM4 GPR156

1.72e-0422933PS50259
DomainGPCR_3_C

GABBR2 GRM4 GPR156

1.72e-0422933IPR017978
DomainMFS

SLC46A2 SLC22A11 SLC2A5 SLC16A5 SLC16A8

2.04e-04108935PS50850
DomainMCT

SLC16A5 SLC16A8

2.43e-045932IPR004743
DomainMFS_dom

SLC46A2 SLC22A11 SLC2A5 SLC16A5 SLC16A8

5.53e-04134935IPR020846
DomainMFS_1

SLC46A2 SLC22A11 SLC16A5 SLC16A8

5.91e-0477934PF07690
DomainMFS

SLC46A2 SLC22A11 SLC16A5 SLC16A8

5.91e-0477934IPR011701
DomainHAD-like_dom

ATP10B ATP10D ATP2C1 ATP2B3

6.51e-0479934IPR023214
DomainATPase_P-typ_cyto_domN

ATP10B ATP10D ATP2B3

6.97e-0435933IPR023299
DomainMyosin_head_motor_dom

MYH1 MYH3 MYH8

8.89e-0438933IPR001609
DomainMYOSIN_MOTOR

MYH1 MYH3 MYH8

8.89e-0438933PS51456
DomainMyosin_head

MYH1 MYH3 MYH8

8.89e-0438933PF00063
DomainMYSc

MYH1 MYH3 MYH8

8.89e-0438933SM00242
DomainP_typ_ATPase_c

ATP10B ATP10D

2.15e-0314932IPR032630
DomainP-type_ATPase_N

ATP10B ATP10D

2.15e-0314932IPR032631
DomainP-type_ATPase_IV

ATP10B ATP10D

2.15e-0314932IPR006539
DomainGPCR_3_CS

GABBR2 GRM4

2.15e-0314932IPR017979
DomainPhoLip_ATPase_C

ATP10B ATP10D

2.15e-0314932PF16212
DomainPhoLip_ATPase_N

ATP10B ATP10D

2.15e-0314932PF16209
Domain-

ATP2C1 ATP2B3

2.81e-03169321.20.1110.10
DomainATPase_P-typ_TM_dom

ATP2C1 ATP2B3

2.81e-0316932IPR023298
DomainATPase_P-typ_cation-transptr_C

ATP2C1 ATP2B3

3.18e-0317932IPR006068
DomainCation_ATPase_C

ATP2C1 ATP2B3

3.18e-0317932PF00689
DomainCation_ATPase_N

ATP2C1 ATP2B3

3.56e-0318932PF00690
DomainCation_ATPase_N

ATP2C1 ATP2B3

3.56e-0318932SM00831
DomainATPase_P-typ_cation-transptr_N

ATP2C1 ATP2B3

3.97e-0319932IPR004014
PathwayREACTOME_SENSORY_PERCEPTION

TRPM4 OR2L8 OR5M9 OR2L3 OR5AK2 OR11H7 OR1S2 APOB OR5M3 OR5M8 GRM4 OR1D2 OR6C75 OR52E1 KCNMB1 OR1E3 OR8D4

6.28e-086367917M41834
PathwayREACTOME_OLFACTORY_SIGNALING_PATHWAY

OR2L8 OR5M9 OR2L3 OR5AK2 OR11H7 OR1S2 OR5M3 OR5M8 OR1D2 OR6C75 OR52E1 OR1E3 OR8D4

4.94e-074177913M4072
PathwayREACTOME_TRANSPORT_OF_SMALL_MOLECULES

TRPM4 SLC22A11 PSMC2 SLC28A3 ATP10B APOB ABCA9 ATP10D SLC6A7 SLC9B1 ATP2C1 CLCN6 ATP2B3 SLC16A8

5.21e-057367914M27287
PathwayREACTOME_ION_CHANNEL_TRANSPORT

TRPM4 ATP10B ATP10D SLC9B1 ATP2C1 CLCN6 ATP2B3

5.71e-05176797MM15718
PathwayKEGG_OLFACTORY_TRANSDUCTION

OR2L8 OR5M9 OR2L3 OR5AK2 OR1S2 OR5M3 OR5M8 OR1D2 OR6C75 OR8D4

6.02e-053897910M14091
PathwayREACTOME_ION_CHANNEL_TRANSPORT

TRPM4 ATP10B ATP10D SLC9B1 ATP2C1 CLCN6 ATP2B3

7.30e-05183797M997
PathwayREACTOME_TRANSPORT_OF_SMALL_MOLECULES

TRPM4 PSMC2 SLC28A3 ATP10B APOB ABCA9 ATP10D SLC6A7 SLC9B1 ATP2C1 CLCN6 ATP2B3 SLC16A8

9.63e-056817913MM14985
PathwayWP_GPCRS_ODORANT

GPR20 VN1R17P OR1E3 GPR156 CMKLR1 PTGDR2

2.47e-04157796MM15872
PathwayREACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES

ATP10B ATP10D ATP2C1 ATP2B3

2.51e-0455794M971
PathwayREACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES

ATP10B ATP10D ATP2C1 ATP2B3

2.88e-0457794MM15643
Pubmed

Different evolutionary processes shaped the mouse and human olfactory receptor gene families.

OR2L8 OR5M9 OR2L3 OR5AK2 OR11H7 OR1S2 OR5M3 OR5M8 OR1D2 OR6C75 OR1E3 OR8D4

3.05e-103401001211875048
Pubmed

The olfactory receptor gene superfamily of the mouse.

OR2L8 OR5M9 OR2L3 OR5AK2 OR11H7 OR1S2 OR5M3 OR5M8 OR1D2 OR6C75 OR1E3 OR8D4

3.05e-103401001211802173
Pubmed

A unified nomenclature for vertebrate olfactory receptors.

OR2L8 OR5M9 OR2L3 OR5AK2 OR11H7 OR1S2 OR5M3 OR5M8 OR1D2 OR6C75 OR1E3 OR8D4

3.38e-103431001232295537
Pubmed

Odorant receptor expressed sequence tags demonstrate olfactory expression of over 400 genes, extensive alternate splicing and unequal expression levels.

OR2L8 OR5M9 OR2L3 OR5AK2 OR11H7 OR1S2 OR5M3 OR5M8 OR1D2 OR6C75 OR1E3 OR8D4

3.73e-103461001214611657
Pubmed

Evaluation of embryonic and perinatal myosin gene mutations and the etiology of congenital idiopathic clubfoot.

MYH1 MYH3 MYH8

9.21e-084100320357587
Pubmed

Three linked myosin heavy chain genes clustered within 370 kb of each other show independent transcriptional and post-transcriptional regulation during differentiation of a mouse muscle cell line.

MYH1 MYH3 MYH8

9.21e-08410031985022
Pubmed

Sequential accumulation of mRNAs encoding different myosin heavy chain isoforms during skeletal muscle development in vivo detected with a recombinant plasmid identified as coding for an adult fast myosin heavy chain from mouse skeletal muscle.

MYH1 MYH3 MYH8

2.30e-07510036196357
Pubmed

Developmental pattern of mouse skeletal myosin heavy chain gene transcripts in vivo and in vitro.

MYH1 MYH3 MYH8

2.30e-07510033829126
Pubmed

Distinct myogenic programs of embryonic and fetal mouse muscle cells: expression of the perinatal myosin heavy chain isoform in vitro.

MYH1 MYH3 MYH8

4.58e-07610031728586
Pubmed

Organization of human and mouse skeletal myosin heavy chain gene clusters is highly conserved.

MYH1 MYH3 MYH8

4.58e-076100310077619
Pubmed

Spatial and temporal changes in myosin heavy chain gene expression in skeletal muscle development.

MYH1 MYH3 MYH8

4.58e-076100310588881
Pubmed

A fast Myosin super enhancer dictates muscle fiber phenotype through competitive interactions with Myosin genes.

MYH1 MYH3 MYH8

8.01e-077100335210422
Pubmed

Diversity in transcriptional start site selection and alternative splicing affects the 5'-UTR of mouse striated muscle myosin transcripts.

MYH1 MYH3 MYH8

8.01e-077100316819597
Pubmed

Genes for skeletal muscle myosin heavy chains are clustered and are not located on the same mouse chromosome as a cardiac myosin heavy chain gene.

MYH1 MYH3 MYH8

1.28e-06810033864153
Pubmed

Acceleration of somitic myogenesis in embryos of myogenin promoter-MRF4 transgenic mice.

MYH1 MYH3 MYH8

2.73e-061010038950513
Pubmed

The human olfactory receptor gene family.

OR2L8 OR5M9 OR5AK2 OR11H7 OR1S2 OR5M3 OR5M8 OR1D2 OR1E3 OR8D4

3.78e-065411001014983052
Pubmed

Contractile protein gene expression in primary myotubes of embryonic mouse hindlimb muscles.

MYH1 MYH3 MYH8

6.46e-061310038404542
Pubmed

The inhibition of differentiation caused by TGFbeta in fetal myoblasts is dependent upon selective expression of PKCtheta: a possible molecular basis for myoblast diversification during limb histogenesis.

MYH1 MYH3 MYH8

6.46e-061310038948582
Pubmed

Prognostic role of XTP1/DEPDC1B and SDP35/DEPDC1A in high grade soft-tissue sarcomas.

DEPDC1 DEPDC1B

8.18e-062100229297565
Pubmed

Validation of variants in SLC28A3 and UGT1A6 as genetic markers predictive of anthracycline-induced cardiotoxicity in children.

UGT1A6 SLC28A3

8.18e-062100223441093
Pubmed

Defective excitation-contraction coupling is partially responsible for impaired contractility in hindlimb muscles of Stac3 knockout mice.

MYH1 MYH3 MYH8

8.20e-0614100327184118
Pubmed

Novel pancreatic beta cell-specific proteins: antibody-based proteomics for identification of new biomarker candidates.

DGCR2 PTGDR2

2.45e-053100222465717
Pubmed

The Role of RARG rs2229774, SLC28A3 rs7853758, and UGT1A6*4 rs17863783 Single-nucleotide Polymorphisms in the Doxorubicin-induced Cardiotoxicity in Solid Childhood Tumors.

UGT1A6 SLC28A3

2.45e-053100237828659
Pubmed

Identification of three developmentally controlled isoforms of human myosin heavy chains.

MYH3 MYH8

2.45e-05310021691980
Pubmed

A new role for the calcineurin/NFAT pathway in neonatal myosin heavy chain expression via the NFATc2/MyoD complex during mouse myogenesis.

MYH1 MYH3 MYH8

3.41e-0522100324301466
Pubmed

DEFOG: a practical scheme for deciphering families of genes.

OR5M9 OR11H7 OR1S2 OR5M3 OR5M8 OR1D2

4.24e-05219100612213199
Pubmed

Biology, structure and mechanism of P-type ATPases.

ATP10D ATP2C1 ATP2B3

7.98e-0529100315071553
Pubmed

Multigene family for sarcomeric myosin heavy chain in mouse and human DNA: localization on a single chromosome.

MYH1 MYH3

8.14e-05510026879174
Pubmed

Calpain-6 deficiency promotes skeletal muscle development and regeneration.

MYH3 MYH8

8.14e-055100223935533
Pubmed

Myosin heavy chain isoforms of the murine masseter muscle during pre- and post-natal development.

MYH1 MYH8

8.14e-055100212919077
Pubmed

The G protein-coupled receptor repertoires of human and mouse.

GPR20 GABBR2 GRM4 GPR156

8.19e-0579100412679517
Pubmed

Myosin heavy chain-embryonic regulates skeletal muscle differentiation during mammalian development.

MYH1 MYH3 MYH8

1.18e-0433100332094117
Pubmed

Phospholipid Flippase ATP10A Translocates Phosphatidylcholine and Is Involved in Plasma Membrane Dynamics.

ATP10B ATP10D

1.22e-046100225947375
Pubmed

Chemokine-like receptor 1 regulates skeletal muscle cell myogenesis.

MYH1 CMKLR1

1.22e-046100222460713
Pubmed

Myogenin is required for late but not early aspects of myogenesis during mouse development.

MYH3 MYH8

1.22e-04610027532173
Pubmed

Claudin-like protein 24 interacts with the VEGFR-2 and VEGFR-3 pathways and regulates lymphatic vessel development.

TMEM204 LYVE1

1.22e-046100220439428
Pubmed

ANKK1 is found in myogenic precursors and muscle fibers subtypes with glycolytic metabolism.

MYH1 MYH3

1.70e-047100229758057
Pubmed

Temporal regulation of the Mediator complex during muscle proliferation, differentiation, regeneration, aging, and disease.

MYH1 MYH3 MYH8

1.96e-0439100338690566
Pubmed

Long noncoding RNA lncMREF promotes myogenic differentiation and muscle regeneration by interacting with the Smarca5/p300 complex.

MYH1 MYH3

2.27e-048100236200826
Pubmed

Gene knockout studies of Ca2+-transporting ATPases.

ATP2C1 ATP2B3

2.27e-048100210951186
Pubmed

Polymorphisms in steroid hormone pathway genes and mammographic density.

CYP1B1 NCOA3

2.27e-048100212602902
Pubmed

Skeletal muscle phenotypes initiated by ectopic MyoD in transgenic mouse heart.

MYH3 MYH8

2.27e-04810021618148
Pubmed

Serine/Threonine Kinase 40 (Stk40) Functions as a Novel Regulator of Skeletal Muscle Differentiation.

MYH3 MYH8

2.27e-048100227899448
Pubmed

Mouse-human orthology relationships in an olfactory receptor gene cluster.

OR1D2 OR1E3

2.27e-048100211170746
Pubmed

E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.

MYH1 MYH3 SLC28A3 DGKH BIRC6 FBXL7 BTD CEP295 HADHA

2.78e-04736100929676528
Pubmed

Muscle-specific gene expression during myogenesis in the mouse.

MYH3 MYH8

2.91e-04910027787235
Pubmed

HOXA5 plays tissue-specific roles in the developing respiratory system.

MYH1 MYH3 MYH8

3.20e-0446100328827394
Pubmed

The expression of myosin genes in developing skeletal muscle in the mouse embryo.

MYH3 MYH8

3.63e-041010022211821
Pubmed

Polymorphisms in phase I and phase II metabolism genes and risk of chronic benzene poisoning in a Chinese occupational population.

CYP1B1 UGT1A6

3.63e-0410100218784359
Pubmed

During muscle atrophy, thick, but not thin, filament components are degraded by MuRF1-dependent ubiquitylation.

MYH1 MYH8

3.63e-0410100219506036
Pubmed

An intrinsic distinction in neuromuscular junction assembly and maintenance in different skeletal muscles.

MYH3 RAPSN

4.43e-0411100211988168
Pubmed

Olfactory receptor gene cluster on human chromosome 17: possible duplication of an ancestral receptor repertoire.

OR1D2 OR1E3

4.43e-041110028004088
Pubmed

Modulation of contractile protein gene expression in fetal murine crural muscles: emergence of muscle diversity.

MYH1 MYH8

4.43e-041110028136524
Pubmed

The FgfrL1 receptor is required for development of slow muscle fibers.

MYH3 MYH8

4.43e-0411100225172430
Pubmed

Calcineurin is necessary for the maintenance but not embryonic development of slow muscle fibers.

MYH1 MYH3

4.43e-0411100216024798
Pubmed

KLF4 regulates skeletal muscle development and regeneration by directly targeting P57 and Myomixer.

MYH1 MYH3

5.30e-0412100237723138
Pubmed

ATP9B, a P4-ATPase (a putative aminophospholipid translocase), localizes to the trans-Golgi network in a CDC50 protein-independent manner.

ATP10B ATP10D

5.30e-0412100221914794
Pubmed

Dysregulation of nuclear receptor COUP-TFII impairs skeletal muscle development.

MYH3 MYH8

5.30e-0412100228600496
Pubmed

Evidence for in vivo production of Humanin peptide, a neuroprotective factor against Alzheimer's disease-related insults.

MTRNR2L10 MTRNR2L11

6.25e-0413100212009529
Pubmed

Failure of Myf5 to support myogenic differentiation without myogenin, MyoD, and MRF4.

MYH1 MYH3

6.25e-0413100210694423
Pubmed

Evidence for potential functionality of nuclearly-encoded humanin isoforms.

MTRNR2L10 MTRNR2L11

6.25e-0413100219477263
Pubmed

Genesis of muscle fiber-type diversity during mouse embryogenesis relies on Six1 and Six4 gene expression.

MYH1 MYH3 MYH8

6.34e-0458100321884692
Pubmed

A rescue factor abolishing neuronal cell death by a wide spectrum of familial Alzheimer's disease genes and Abeta.

MTRNR2L10 MTRNR2L11

7.28e-0414100211371646
Pubmed

Hepatoblasts comprise a niche for fetal liver erythropoiesis through cytokine production.

LYVE1 THPO

7.28e-0414100221664343
Pubmed

The SLC16 gene family-from monocarboxylate transporters (MCTs) to aromatic amino acid transporters and beyond.

SLC16A5 SLC16A8

7.28e-0414100212739169
Pubmed

L-type voltage-dependent calcium channel alpha subunit 1C is a novel candidate gene associated with secondary hyperparathyroidism: an application of haplotype-based analysis for multiple linked single nucleotide polymorphisms.

GABBR2 SLC6A7 KCNMB1 SLC16A8

7.91e-04143100420424473
Pubmed

Genetic variation of genes for xenobiotic-metabolizing enzymes and risk of bronchial asthma: the importance of gene-gene and gene-environment interactions for disease susceptibility.

CYP1B1 UGT1A6

8.39e-0415100219575027
Pubmed

Six homeoproteins and a Iinc-RNA at the fast MYH locus lock fast myofiber terminal phenotype.

MYH1 MYH3

8.39e-0415100224852826
Pubmed

Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy.

CYP1B1 UGT1A6 CLCN6

9.25e-0466100319898482
Pubmed

DelK32-lamin A/C has abnormal location and induces incomplete tissue maturation and severe metabolic defects leading to premature death.

MYH3 MYH8

9.57e-0416100222090424
Pubmed

Sequence, structure, and evolution of a complete human olfactory receptor gene cluster.

OR1D2 OR1E3

9.57e-0416100210673334
Pubmed

Slow and fast fiber isoform gene expression is systematically altered in skeletal muscle of the Sox6 mutant, p100H.

MYH3 MYH8

1.08e-0317100216124007
Pubmed

IKKα and alternative NF-κB regulate PGC-1β to promote oxidative muscle metabolism.

MYH1 COX5A

1.08e-0317100222351927
Pubmed

Genetic polymorphisms in phase I and phase II enzymes and breast cancer risk associated with menopausal hormone therapy in postmenopausal women.

CYP1B1 UGT1A6

1.08e-0317100219424794
Pubmed

Defective myogenesis in the absence of the muscle-specific lysine methyltransferase SMYD1.

MYH3 MYH8

1.22e-0318100226688546
Pubmed

M-phase kinases induce phospho-dependent ubiquitination of somatic Wee1 by SCFbeta-TrCP.

FBXL7 FBXW5

1.22e-0318100215070733
Pubmed

Findings from bipolar disorder genome-wide association studies replicate in a Finnish bipolar family-cohort.

DGKH GABBR2

1.22e-0318100219308021
Pubmed

140 mouse brain proteins identified by Ca2+-calmodulin affinity chromatography and tandem mass spectrometry.

RELCH PDE1B BIRC6 ATP2B3

1.29e-03163100416512683
Pubmed

Disruption of the mouse MRF4 gene identifies multiple waves of myogenesis in the myotome.

MYH3 MYH8

1.50e-032010027588068
Pubmed

CFTR interactome mapping using the mammalian membrane two-hybrid high-throughput screening system.

OTUD6A SAMD4B OR5M8 SLC9B1 SEC22C PGAP2

1.74e-03440100635156780
Pubmed

Opposing gene regulatory programs governing myofiber development and maturation revealed at single nucleus resolution.

MYH3 MYH8

1.82e-0322100237468485
Pubmed

Genome-wide association study to identify single nucleotide polymorphisms (SNPs) associated with the development of erectile dysfunction in African-American men after radiotherapy for prostate cancer.

APOB CMKLR1

1.99e-0323100220932654
Pubmed

Overlapping functions of SIX homeoproteins during embryonic myogenesis.

MYH3 MYH8

2.17e-0324100237267426
Pubmed

ZFP36L2 is a cell cycle-regulated CCCH protein necessary for DNA lesion-induced S-phase arrest.

DGCR2 ATP2C1 HADHA CARS2

2.21e-03189100429449217
Pubmed

Candidate gene analysis in primary lymphedema.

LYVE1 CMKLR1

2.35e-0325100218564921
Pubmed

Association of candidate gene polymorphisms with chronic kidney disease in Japanese individuals with hypertension.

APOB KCNMB1

2.54e-0326100219282863
Pubmed

Characterization of carbonic anhydrase IX interactome reveals proteins assisting its nuclear localization in hypoxic cells.

HADHA XPOT

2.54e-0326100223181366
Pubmed

Tagging genes with cassette-exchange sites.

NCOA3 RELCH BIRC6 PPTC7 XPOT

2.87e-03335100515741177
Cytoband11q12.1

OR5M9 OR5AK2 OR1S2 OR5M3 OR5M8

2.87e-05161100511q12.1
CytobandEnsembl 112 genes in cytogenetic band chr11q12

OR5M9 OR5AK2 OR1S2 OR5M3 OR5M8 PTGDR2

1.14e-043451006chr11q12
Cytoband17q25.1

ARMC7 OTOP3 SLC16A5

7.56e-0481100317q25.1
CytobandEnsembl 112 genes in cytogenetic band chr17p13

MYH1 MYH3 MYH8 OR1D2 OR1E3

9.91e-043461005chr17p13
Cytoband1q44

OR2L8 OR2L3 VN1R17P

1.83e-0311010031q44
Cytoband17p13.1

MYH1 MYH3 MYH8

2.23e-03118100317p13.1
Cytoband5q34

ATP10B KCNMB1

2.23e-033210025q34
CytobandEnsembl 112 genes in cytogenetic band chr1q44

OR2L8 OR2L3 VN1R17P

2.81e-031281003chr1q44
Cytoband10q22.2

SAMD8 DUSP29

3.64e-0341100210q22.2
CytobandEnsembl 112 genes in cytogenetic band chr12q23

AMDHD1 CHST11 CMKLR1

4.39e-031501003chr12q23
Cytoband9q32

SLC46A2 TMEM268

4.76e-034710029q32
CytobandEnsembl 112 genes in cytogenetic band chr9q32

SLC46A2 TMEM268

5.38e-03501002chr9q32
GeneFamilyMyosin heavy chains

MYH1 MYH3 MYH8

3.39e-05157831098
GeneFamilySolute carriers

SLC46A2 SLC22A11 SLC28A3 SLC2A5 SLC6A7 SLC9B1 SLC16A5 SLC16A8

2.99e-04395788752
GeneFamilyATPases Ca2+ transporting

ATP2C1 ATP2B3

6.49e-0497821209
GeneFamilyOlfactory receptors, family 1

OR1S2 OR1D2 OR1E3

6.80e-0440783147
GeneFamilyOlfactory receptors, family 5

OR5M9 OR5AK2 OR5M3 OR5M8

1.40e-03112784152
GeneFamilyATPase phospholipid transporting

ATP10B ATP10D

1.86e-03157821210
Diseaseautosomal dominant hyaline body myopathy (implicated_via_orthology)

MYH1 MYH3 MYH8

3.70e-0610943DOID:0111269 (implicated_via_orthology)
Diseasedistal arthrogryposis type 2B3 (implicated_via_orthology)

MYH1 MYH3 MYH8

3.70e-0610943DOID:0111602 (implicated_via_orthology)
Diseasedistal arthrogryposis type 1 (implicated_via_orthology)

MYH1 MYH3 MYH8

3.70e-0610943DOID:0111596 (implicated_via_orthology)
Diseasedilated cardiomyopathy 1S (implicated_via_orthology)

MYH1 MYH3 MYH8

3.70e-0610943DOID:0110454 (implicated_via_orthology)
Diseasecongenital myopathy 6 (implicated_via_orthology)

MYH1 MYH3 MYH8

3.70e-0610943DOID:0080719 (implicated_via_orthology)
Diseaseinclusion body myositis (implicated_via_orthology)

MYH1 MYH3 MYH8

3.70e-0610943DOID:3429 (implicated_via_orthology)
Diseasedistal arthrogryposis type 2A (implicated_via_orthology)

MYH1 MYH3 MYH8

3.70e-0610943DOID:0111605 (implicated_via_orthology)
Diseasefamilial hypertrophic cardiomyopathy (implicated_via_orthology)

MYH1 MYH3 MYH8

3.70e-0610943DOID:0080326 (implicated_via_orthology)
Diseasedistal myopathy (implicated_via_orthology)

MYH1 MYH3 MYH8

6.75e-0612943DOID:11720 (implicated_via_orthology)
Diseasemyotonia congenita (implicated_via_orthology)

MYH1 MYH3 MYH8

6.75e-0612943DOID:2106 (implicated_via_orthology)
Diseaserestrictive cardiomyopathy (implicated_via_orthology)

MYH1 MYH3 MYH8

8.75e-0613943DOID:397 (implicated_via_orthology)
Diseasedistal arthrogryposis (implicated_via_orthology)

MYH1 MYH3 MYH8

1.39e-0515943DOID:0050646 (implicated_via_orthology)
Diseaseprogressive familial intrahepatic cholestasis (implicated_via_orthology)

ATP10B ATP10D

3.01e-053942DOID:0070221 (implicated_via_orthology)
DiseaseHailey-Hailey disease (implicated_via_orthology)

ATP2C1 ATP2B3

1.49e-046942DOID:0050429 (implicated_via_orthology)
Diseaseglycosyl-N-behenoyl-sphingadienine (d18:2/22:0) measurement

ATP10D TMEM268

2.09e-047942EFO_0800520
Diseasedual specificity protein phosphatase 13 isoform A measurement

SAMD8 DUSP29

2.78e-048942EFO_0801549
DiseaseDistal arthrogryposis

MYH3 MYH8

3.56e-049942cv:C0265213
Diseaseglycosyl-N-palmitoyl-sphingosine (d18:1/16:0) measurement

ATP10D TMEM268

3.56e-049942EFO_0800476
Diseaseconcentration of large LDL particles measurement

RAPSN APOB IGSF23

3.77e-0444943EFO_0022160
Diseasetriacylglycerol 54:4 measurement

RAPSN APOB GABBR2

4.30e-0446943EFO_0010422
Diseasemyopathy (implicated_via_orthology)

MYH1 MYH3 MYH8

4.88e-0448943DOID:423 (implicated_via_orthology)
Diseasetotal lipids in medium LDL

RAPSN APOB IGSF23

6.18e-0452943EFO_0022180
Diseasebiliverdin measurement

UGT1A6 GRM4

6.49e-0412942EFO_0021033
Diseaseresponse to statin

RAPSN SLC28A3 APOB

7.68e-0456943GO_0036273
Diseasecardiomyopathy (implicated_via_orthology)

MYH1 MYH3 MYH8

1.53e-0371943DOID:0050700 (implicated_via_orthology)
Diseaseresponse to mitochondrial complex I inhibitor

CHST11 GABBR2

1.66e-0319942EFO_0600033
Diseasesodium-coupled monocarboxylate transporter 1 measurement

RAPSN APOB

1.66e-0319942EFO_0802076
Diseasedilated cardiomyopathy (implicated_via_orthology)

MYH1 MYH3 MYH8

2.15e-0380943DOID:12930 (implicated_via_orthology)
Diseaseproprotein convertase subtilisin/kexin type 9 measurement

RAPSN APOB

2.23e-0322942EFO_0009312
Diseaseliver fibrosis measurement

RAPSN APOB BCAR3

2.65e-0386943EFO_0010576
Diseasearachidonic acid measurement

RAPSN CHST11

2.87e-0325942EFO_0006808
DiseaseCFTR mutation carrier status

SLC28A3 THSD7B

2.87e-0325942EFO_0021794
Diseaselevel of Sterol ester (27:1/18:2) in blood serum

RAPSN APOB

3.10e-0326942OBA_2045194
Diseaselevel of Sterol ester (27:1/16:0) in blood serum

RAPSN APOB

3.10e-0326942OBA_2045191

Protein segments in the cluster

PeptideGeneStartEntry
FCGVLSLRTSEGLMR

C1orf140

106

Q5VVS0
RVFMLLSCIGQRSLS

BIRC6

2116

Q9NR09
VLSMDCRVARILGVS

BCAR3

556

O75815
VAIMVSGRLRCIGSI

ABCA9

1491

Q8IUA7
TCSLRRIFLGLGMSI

GRM4

651

Q14833
VISVFTGRIMCALSR

GPR20

211

Q99678
GTRTLMVQTFSRCIL

DEPDC1B

351

Q8WUY9
MRSTILLFCLLGSTR

AMTN

1

Q6UX39
IRKCQRAGITVRMVT

ATP2B3

691

Q16720
ASRSNIAFMGTLVRC

ATP2C1

211

P98194
LRGCTIRNTEMAVGI

ATP10B

271

O94823
GTLTENKMVFRRCSV

ATP10D

441

Q9P241
RATMVLACVLSALGI

CLDN20

81

P56880
VMGALTRVSQRICSG

OR2L3

296

Q8NG85
SSDLMGRFRVLGCLV

RAPSN

36

Q13702
MATRGFSCLLLVISE

MTRNR2L11

1

S4R3Y5
ILTMTCISVERFLGV

P2RY8

111

Q86VZ1
RGETRALCLGVTMVV

KCNMB1

11

Q16558
SILVTRFGCRPVMLA

SLC16A8

76

O95907
LVFSVSVEMLRCRTA

OTUD6A

161

Q7L8S5
TSALVRCTAARMFEL

RELCH

976

Q9P260
MGIARLSCASIRVNI

OR52E1

181

Q8NGJ3
VRVQTNFTRCGLMLT

OTOP3

221

Q7RTS5
MSPRVCSLLVAAVFS

OR8D4

136

Q8NGM9
RLRFTMVALVTVCCP

PGAP2

16

Q9UHJ9
SIQVSCRIMGITLVS

LYVE1

31

Q9Y5Y7
MESRVLLRTFCLIFG

NELL2

1

Q99435
ASTVRTVMVADCSRF

FBXW5

246

Q969U6
QIITRTQAVCRGFLM

MYH8

786

P13535
SASRVFCGRILSMVN

KXD1

6

Q9BQD3
VMGALTRVSQRICSV

OR2L8

296

Q8NGY9
VTQTVHCFLLRTGMV

PDE1B

231

Q01064
GTRSLMIHTFSRCVL

DEPDC1

641

Q5TB30
LMGRTITAVLTTFCF

LPCAT3

106

Q6P1A2
AQLITRTQAMCRGFL

MYH1

786

P12882
VVQCMLRFSLSASAR

ARMC7

141

Q9H6L4
GSKMSRVVCIRLITF

OR5M3

131

Q8NGP4
SFTIITPFRRLMLCA

DGKH

126

Q86XP1
GVILFVVGCRMRQTV

PTGDR2

51

Q9Y5Y4
MTTRGFSCLLLLIRE

MTRNR2L10

1

P0CJ77
TTFMRARFGTLLTVI

OR1S2

146

Q8NGQ3
SQFSGTLMRTCERLV

PPTC7

91

Q8NI37
MSRTVCIRLVAGSYI

OR5AK2

136

Q8NH90
LCTMFIREVGTVLSQ

APOB

4216

P04114
TVVVFVASMVLGECR

CLCN6

386

P51797
AGMCFIIIQSLRTDR

IGSF23

171

A1L1A6
RGMTFNLIGESTIRC

CR1

1356

P17927
HCVMGRSRSATLVLA

DUSP29

146

Q68J44
LMLETVTVSGCRRLT

FBXL7

186

Q9UJT9
RAKSRFVVCIMSGAR

BTD

11

P43251
SGMRLVVSCISSFLI

DGCR2

346

P98153
GIVAMATARCSAILL

AMDHD1

291

Q96NU7
MVACRAIGILSRFSA

HADHA

1

P40939
IMCIIGAAVSFLTRD

GABBR2

701

O75899
QTRLSMLCIGTSLVF

GPR156

121

Q8NFN8
LTSRVMIFSVGKRRC

CYP1B1

456

Q16678
SRLCVRTVEMGTSIQ

CEP295

2321

Q9C0D2
MLGAALRRCAVAATT

COX5A

1

P20674
RRAVTMTVVGCAFSA

SLC22A11

226

Q9NSA0
MSVIFFACVVRVRDG

SEC22C

1

Q9BRL7
TIIMSTRVCTLLVFS

OR6C75

131

A6NL08
MSCARIVSTILRVPS

OR1E3

216

Q8WZA6
IFTLTGNMAIICAVR

OR11H7

36

Q8NGC8
LLMTRVTFCGSRKIH

OR1D2

161

P34982
RVRMVTVGIVCTSPI

GARIN3

66

Q8TC56
RSVCTEAGMFAIRAR

PSMC2

386

P35998
RRILTKVFGCSIVMV

CARS2

101

Q9HA77
SILLRRLCSLMGTVF

SAMD8

226

Q96LT4
MGCSRVATSFELIII

SLC2A5

116

P22732
MICVARRITTGERTF

NCOA3

246

Q9Y6Q9
LITVGLRATRPAFMC

PRDM7

61

Q9NQW5
GCIEVLRSMRSLDFS

SHC3

161

Q92529
ITRTQAVCRGFLMRV

MYH3

786

P11055
MRRNCTLVTEFILLG

OR5M8

1

Q8NGP6
AVRALIAGTVACFMT

SLC28A3

591

Q9HAS3
VTGLALREMACISRS

KIF25

281

Q9UIL4
MAIFASVCLASRLPR

PIGC

181

Q92535
GSKMSRTVCVRLISV

OR5M9

131

Q8NGP3
GLMVVVITTCLAVTR

SLC6A7

461

Q99884
RTTTFMLVGICLSIQ

TDGF1

171

P13385
RHMVVTVTRFLCGFL

CMKLR1

216

Q99788
RMVLATCLGSFILVI

CHST11

16

Q9NPF2
TIIVCGMVAALSAIR

CLEC2D

46

Q9UHP7
LRYCMTVSGTVVLVA

TMEM61

16

Q8N0U2
RSRLSQLCVVMETGV

TMEM268

226

Q5VZI3
SILVGRFGCRVTVML

SLC16A5

71

O15375
TRVMGKVCTQLLVSR

SAMD4B

476

Q5PRF9
TLKRGFLVLTMCVSA

SLC9B1

316

Q4ZJI4
SIDIVCLAGFMRILS

GART

886

P22102
MRLVARVTVFLTFGT

TRAV26-1

1

A0A087WT03
RSGVRTFLHRMIICL

XPOT

701

O43592
LGVLVFSRCFRDTTM

SLC46A2

336

Q9BY10
DCMAPRVIVISRSLT

TMEM204

196

Q9BSN7
CKIITFLNRVMRGVS

VN1R17P

86

Q8TDU5
FLNRVMRGVSICTTC

VN1R17P

91

Q8TDU5
RRVFCVKSHVGQVMT

THSD7B

701

Q9C0I4
MACLLRSFQRISAGV

UGT1A6

1

P19224
RTTTFMLAGICLSIQ

TDGF1P3

171

P51864
IARGLMVTCGTDRIV

WDFY1

376

Q8IWB7
GRTVLCIDFMVFTVR

TRPM4

891

Q8TD43
CFSAVVLLSMLREGT

UCMA

11

Q8WVF2
RFLMLVGGSTLCVRR

THPO

161

P40225
LTIRTGAMARLECAA

LRIG2

611

O94898
LMIRRCIETGTRQFG

LONRF3

581

Q496Y0