Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	glutaminase activity	CAD NADSYN1 GLS	6.48e-07	4	110	3	GO:0004359
GeneOntologyCellularComponent	cytoplasmic side of plasma membrane	RASGRP4 CARMIL2 DTNA PGM5 SHROOM4 SNX18 GNB2	5.94e-05	185	111	7	GO:0009898
GeneOntologyCellularComponent	spot adherens junction	PGM5 PKP3	8.35e-05	3	111	2	GO:0005914
GeneOntologyCellularComponent	integrator complex	SAGE2P INTS10 NIPBL	1.81e-04	21	111	3	GO:0032039
GeneOntologyCellularComponent	cytoplasmic side of membrane	RASGRP4 CARMIL2 DTNA PGM5 SHROOM4 SNX18 GNB2	2.29e-04	230	111	7	GO:0098562
GeneOntologyCellularComponent	organelle outer membrane	SYNE1 SPATA18 AMBRA1 RHOT2 TRIM14 PLEC TMEM109	7.29e-04	279	111	7	GO:0031968
GeneOntologyCellularComponent	outer membrane	SYNE1 SPATA18 AMBRA1 RHOT2 TRIM14 PLEC TMEM109	7.61e-04	281	111	7	GO:0019867
Domain	p53-like_TF_DNA-bd	STAT5A STAT5B TBX18 NFKB2	2.49e-04	53	108	4	IPR008967
Domain	Glyco_hydro_38_C	MAN2A2 MAN2B2	3.28e-04	5	108	2	IPR011682
Domain	Alpha-mann_mid	MAN2A2 MAN2B2	3.28e-04	5	108	2	PF09261
Domain	Glyco_hydro_57/38_cen	MAN2A2 MAN2B2	3.28e-04	5	108	2	IPR028995
Domain	Glyco_hydro_38	MAN2A2 MAN2B2	3.28e-04	5	108	2	PF01074
Domain	-	MAN2A2 MAN2B2	3.28e-04	5	108	2	1.20.1270.50
Domain	-	MAN2A2 MAN2B2	3.28e-04	5	108	2	3.20.110.10
Domain	Alpha-mann_mid	MAN2A2 MAN2B2	3.28e-04	5	108	2	SM00872
Domain	Glyco_hydro_38_N	MAN2A2 MAN2B2	3.28e-04	5	108	2	IPR000602
Domain	Glyco_hydro_38/57_N	MAN2A2 MAN2B2	3.28e-04	5	108	2	IPR027291
Domain	Glyco_hydro_38_cen	MAN2A2 MAN2B2	3.28e-04	5	108	2	IPR015341
Domain	Glyco_hydro_38C	MAN2A2 MAN2B2	3.28e-04	5	108	2	PF07748
Domain	WD40_repeat_CS	KATNB1 GEMIN5 AMBRA1 NWD2 HERC1 GNB2	3.82e-04	164	108	6	IPR019775
Domain	-	EPPK1 PLEC	4.89e-04	6	108	2	3.90.1290.10
Domain	STAT_TF_DNA-bd_sub	STAT5A STAT5B	6.83e-04	7	108	2	IPR012345
Domain	STAT	STAT5A STAT5B	6.83e-04	7	108	2	IPR001217
Domain	STAT_int	STAT5A STAT5B	6.83e-04	7	108	2	SM00964
Domain	STAT_TF_DNA-bd	STAT5A STAT5B	6.83e-04	7	108	2	IPR013801
Domain	STAT_bind	STAT5A STAT5B	6.83e-04	7	108	2	PF02864
Domain	STAT_int	STAT5A STAT5B	6.83e-04	7	108	2	PF02865
Domain	Plectin	EPPK1 PLEC	6.83e-04	7	108	2	PF00681
Domain	-	STAT5A STAT5B	6.83e-04	7	108	2	1.10.532.10
Domain	STAT_alpha	STAT5A STAT5B	6.83e-04	7	108	2	PF01017
Domain	-	STAT5A STAT5B	6.83e-04	7	108	2	1.20.1050.20
Domain	STAT_TF_prot_interaction	STAT5A STAT5B	6.83e-04	7	108	2	IPR013799
Domain	Plectin_repeat	EPPK1 PLEC	6.83e-04	7	108	2	IPR001101
Domain	STAT_TF_coiled-coil	STAT5A STAT5B	6.83e-04	7	108	2	IPR015988
Domain	-	STAT5A STAT5B	6.83e-04	7	108	2	2.60.40.630
Domain	Glyco_hydro/deAcase_b/a-brl	MAN2A2 MAN2B2	6.83e-04	7	108	2	IPR011330
Domain	PLEC	EPPK1 PLEC	6.83e-04	7	108	2	SM00250
Domain	STAT_TF_alpha	STAT5A STAT5B	9.07e-04	8	108	2	IPR013800
Domain	PDZ	FRMPD4 ARHGAP23 PDZD7 SHROOM4 FRMPD3	1.37e-03	141	108	5	PF00595
Domain	PDZ	FRMPD4 ARHGAP23 PDZD7 SHROOM4 FRMPD3	1.69e-03	148	108	5	SM00228
Domain	PTBI	IRS1 IRS2	1.76e-03	11	108	2	SM00310
Domain	-	FRMPD4 ARHGAP23 PDZD7 SHROOM4 FRMPD3	1.79e-03	150	108	5	2.30.42.10
Domain	PDZ	FRMPD4 ARHGAP23 PDZD7 SHROOM4 FRMPD3	1.85e-03	151	108	5	PS50106
Domain	PDZ	FRMPD4 ARHGAP23 PDZD7 SHROOM4 FRMPD3	1.90e-03	152	108	5	IPR001478
Domain	IRS_PTB	IRS1 IRS2	2.11e-03	12	108	2	PS51064
Domain	IRS	IRS1 IRS2	2.88e-03	14	108	2	PF02174
Domain	-	MAN2A2 MAN2B2	2.88e-03	14	108	2	2.60.40.1180
Domain	IRS_PTB	IRS1 IRS2	2.88e-03	14	108	2	IPR002404
Domain	-	KATNB1 BBS1 GEMIN5 AMBRA1 NWD2 HERC1 GNB2	3.22e-03	333	108	7	2.130.10.10
Domain	Glyco_hydro_b	MAN2A2 MAN2B2	3.31e-03	15	108	2	IPR013780
Domain	WD40/YVTN_repeat-like_dom	KATNB1 BBS1 GEMIN5 AMBRA1 NWD2 HERC1 GNB2	3.33e-03	335	108	7	IPR015943
Domain	Gal_mutarotase_SF_dom	MAN2A2 MAN2B2	4.26e-03	17	108	2	IPR011013
Domain	-	TG NID1	4.26e-03	17	108	2	4.10.800.10
Domain	Thyroglobulin_1	TG NID1	4.26e-03	17	108	2	IPR000716
Domain	THYROGLOBULIN_1_1	TG NID1	4.26e-03	17	108	2	PS00484
Domain	TY	TG NID1	4.26e-03	17	108	2	SM00211
Domain	THYROGLOBULIN_1_2	TG NID1	4.26e-03	17	108	2	PS51162
Domain	Thyroglobulin_1	TG NID1	4.26e-03	17	108	2	PF00086
Domain	WD40	KATNB1 GEMIN5 AMBRA1 NWD2 HERC1 GNB2	4.67e-03	268	108	6	SM00320
Domain	WD40_repeat	KATNB1 GEMIN5 AMBRA1 NWD2 HERC1 GNB2	5.01e-03	272	108	6	IPR001680
Domain	WD_REPEATS_1	KATNB1 GEMIN5 AMBRA1 NWD2 HERC1 GNB2	5.56e-03	278	108	6	PS00678
Domain	WD_REPEATS_2	KATNB1 GEMIN5 AMBRA1 NWD2 HERC1 GNB2	5.66e-03	279	108	6	PS50082
Domain	WD_REPEATS_REGION	KATNB1 GEMIN5 AMBRA1 NWD2 HERC1 GNB2	5.66e-03	279	108	6	PS50294
Pathway	REACTOME_SIGNALING_BY_LEPTIN	IRS1 STAT5A STAT5B IRS2	2.93e-07	11	79	4	M27195
Pathway	REACTOME_ERYTHROPOIETIN_ACTIVATES_STAT5	STAT5A STAT5B IRS2	5.83e-06	7	79	3	M27907
Pathway	REACTOME_GROWTH_HORMONE_RECEPTOR_SIGNALING	IRS1 STAT5A STAT5B IRS2	8.91e-06	24	79	4	M519
Pathway	WP_EPO_RECEPTOR_SIGNALING	IRS1 STAT5A STAT5B IRS2	1.24e-05	26	79	4	M39687
Pathway	WP_EPO_RECEPTOR_SIGNALING	IRS1 STAT5A STAT5B IRS2	1.24e-05	26	79	4	MM15896
Pathway	REACTOME_INTERLEUKIN_7_SIGNALING	IRS1 STAT5A STAT5B IRS2	4.70e-05	36	79	4	M542
Pathway	REACTOME_INTERLEUKIN_7_SIGNALING	STAT5A STAT5B IRS2	7.34e-05	15	79	3	MM14536
Pathway	WP_IL7_SIGNALING_PATHWAY	IRS1 STAT5A STAT5B IRS2	9.55e-05	43	79	4	MM15864
Pathway	WP_IL4_SIGNALING	IRS1 STAT5A STAT5B IRS2	2.34e-04	54	79	4	M39720
Pathway	PID_IL2_1PATHWAY	IRS1 STAT5A STAT5B IRS2	2.51e-04	55	79	4	M122
Pathway	KEGG_MEDICUS_VARIANT_EML4_ALK_FUSION_KINASE_TO_JAK_STAT_SIGNALING_PATHWAY	STAT5A STAT5B	3.07e-04	5	79	2	M48987
Pathway	KEGG_MEDICUS_VARIANT_DUPLICATION_OR_MUTATION_ACTIVATED_FLT3_TO_JAK_STAT_SIGNALING_PATHWAY	STAT5A STAT5B	3.07e-04	5	79	2	M48986
Pathway	KEGG_MEDICUS_REFERENCE_PRL_JAK_STAT_SIGNALING_PATHWAY	STAT5A STAT5B	3.07e-04	5	79	2	M49006
Pathway	REACTOME_IRS_ACTIVATION	IRS1 IRS2	3.07e-04	5	79	2	M27707
Pathway	REACTOME_SIGNALING_BY_ERYTHROPOIETIN	STAT5A STAT5B IRS2	3.56e-04	25	79	3	M27865
Pathway	BIOCARTA_GH_PATHWAY	IRS1 STAT5A STAT5B	4.50e-04	27	79	3	M9043
Pathway	PID_IL4_2PATHWAY	IRS1 STAT5A STAT5B IRS2	4.50e-04	64	79	4	M28
Pathway	REACTOME_INTERLEUKIN_9_SIGNALING	STAT5A STAT5B	4.58e-04	6	79	2	MM15581
Pathway	REACTOME_INTERLEUKIN_21_SIGNALING	STAT5A STAT5B	4.58e-04	6	79	2	MM15621
Pathway	WP_ALPHA_6_BETA_4_INTEGRIN_SIGNALING_PATHWAY	IRS1 IRS2 PLEC SMAD2	5.06e-04	66	79	4	MM15925
Pathway	WP_AGERAGE_PATHWAY	IRS1 STAT5A STAT5B SMAD2	5.06e-04	66	79	4	M39420
Pathway	REACTOME_NEURONAL_SYSTEM	CHRNA9 HCN3 SLITRK3 PPFIA3 KCNQ4 GLS GNB2 CACNA2D3	5.63e-04	335	79	8	MM14503
Pathway	REACTOME_STAT5_ACTIVATION	STAT5A STAT5B	6.39e-04	7	79	2	M27953
Pathway	KEGG_MEDICUS_PATHOGEN_HTLV_1_P12_TO_JAK_STAT_SIGNALING_PATHWAY	STAT5A STAT5B	6.39e-04	7	79	2	M47581
Pathway	KEGG_MEDICUS_REFERENCE_GH_JAK_STAT_SIGNALING_PATHWAY	STAT5A STAT5B	6.39e-04	7	79	2	M47646
Pathway	KEGG_MEDICUS_REFERENCE_EGF_JAK_STAT_SIGNALING_PATHWAY	STAT5A STAT5B	6.39e-04	7	79	2	M47430
Pathway	REACTOME_SOS_MEDIATED_SIGNALLING	IRS1 IRS2	6.39e-04	7	79	2	M19489
Pathway	WP_DRAVET_SYNDROME_SCN1AA1783V_POINT_MUTATION_MODEL	RICTOR SLC12A5 GLS CACNA2D3	7.42e-04	73	79	4	MM16641
Pathway	PID_EPO_PATHWAY	STAT5A STAT5B IRS2	8.19e-04	33	79	3	M233
Pathway	BIOCARTA_GH_PATHWAY	IRS1 STAT5A STAT5B	8.19e-04	33	79	3	MM1404
Pathway	WP_PROLACTIN_SIGNALING	IRS1 STAT5A STAT5B IRS2	8.63e-04	76	79	4	M39601
Pathway	WP_FACTORS_AND_PATHWAYS_AFFECTING_INSULINLIKE_GROWTH_FACTOR_IGF1AKT_SIGNALING	RICTOR IRS1 SMAD2	1.06e-03	36	79	3	M39569
Pathway	BIOCARTA_IL2RB_PATHWAY	IRS1 STAT5A STAT5B	1.06e-03	36	79	3	MM1418
Pathway	REACTOME_INTERLEUKIN_9_SIGNALING	STAT5A STAT5B	1.09e-03	9	79	2	M27861
Pathway	BIOCARTA_IL22BP_PATHWAY	STAT5A STAT5B	1.09e-03	9	79	2	MM1419
Pathway	REACTOME_PI3K_AKT_ACTIVATION	IRS1 IRS2	1.09e-03	9	79	2	M714
Pathway	BIOCARTA_IL22BP_PATHWAY	STAT5A STAT5B	1.09e-03	9	79	2	M8066
Pathway	BIOCARTA_IL2RB_PATHWAY	IRS1 STAT5A STAT5B	1.15e-03	37	79	3	M8615
Pathway	REACTOME_SIGNAL_ATTENUATION	IRS1 IRS2	1.36e-03	10	79	2	M14236
Pathway	REACTOME_INTERLEUKIN_21_SIGNALING	STAT5A STAT5B	1.36e-03	10	79	2	M27898
Pathway	REACTOME_STAT5_ACTIVATION_DOWNSTREAM_OF_FLT3_ITD_MUTANTS	STAT5A STAT5B	1.36e-03	10	79	2	M41731
Pathway	REACTOME_INTERLEUKIN_2_SIGNALING	STAT5A STAT5B	1.36e-03	10	79	2	MM15618
Pathway	WP_IL2_SIGNALING_PATHWAY	IRS1 STAT5A STAT5B IRS2	1.43e-03	87	79	4	MM15915
Pathway	REACTOME_INTERLEUKIN_15_SIGNALING	STAT5A STAT5B	1.65e-03	11	79	2	MM15578
Pathway	REACTOME_INTERLEUKIN_2_SIGNALING	STAT5A STAT5B	1.97e-03	12	79	2	M27893
Pathway	REACTOME_NEURONAL_SYSTEM	CHRNA9 HCN3 SLITRK3 PPFIA3 KCNQ4 GLS GNB2 CACNA2D3	2.09e-03	411	79	8	M735
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	EPPK1 MAN2A2 INPP5E GEMIN5 AMBRA1 IRS1 RHOT2 TPCN1 CCDC88C C2CD3 NADSYN1 MDN1 NFKB2 KBTBD11 IRS2 LRRC14 PLEC HERC1 SPEN MED12	3.80e-10	1105	112	20	35748872
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	MAN2B2 ARHGAP23 RTEL1 RICTOR TRIM14 PTGFRN ELFN2 SHROOM4 CCDC88C GLS LRRC14 MED12 UNC80	7.57e-09	493	112	13	15368895
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	OGT CENPF GEMIN5 RBBP8NL NOL4L GLS IRS2 PLEC CNOT1 MED12	1.07e-06	418	112	10	34709266
Pubmed	Fetal and neonatal hematopoietic progenitors are functionally and transcriptionally resistant to Flt3-ITD mutations.	RICTOR STAT5A STAT5B	1.80e-06	8	112	3	27879203
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	KCTD9 CAD OGT CENPF SYNE1 HCN3 PPFIA3 SLC12A5 CCDC88C MDN1 FRMPD3 GNB2 CNOT1 NIPBL	2.75e-06	963	112	14	28671696
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	CAD OGT CARMIL2 ARHGAP23 SYNE1 GEMIN5 PPFIA3 ELFN2 SLC12A5 NWD2 CRACDL KBTBD11 PLEC ALDH1B1 GNB2 CNOT1 CACNA2D3	3.36e-06	1431	112	17	37142655
Pubmed	FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.	CENPF STAT5A CRNKL1 MDN1 NID1 IRS2 HERC1 TMEM109 CNOT1 MED12	5.00e-06	497	112	10	36774506
Pubmed	Ski regulates Hippo and TAZ signaling to suppress breast cancer progression.	CAD EPPK1 SAV1 PLEC SMAD2	7.98e-06	84	112	5	25670202
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	CAD EPPK1 CENPF GEMIN5 CRNKL1 MDN1 PLEC SPEN CNOT1 NIPBL MED12	8.88e-06	653	112	11	22586326
Pubmed	Definitive evidence using enucleated cytoplasts for a nongenomic basis for the cystic change in endoplasmic reticulum structure caused by STAT5a/b siRNAs.	STAT5A STAT5B	1.03e-05	2	112	2	23151802
Pubmed	Signal transducer and activator of transcription 5 (STAT5) paralog dose governs T cell effector and regulatory functions.	STAT5A STAT5B	1.03e-05	2	112	2	26999798
Pubmed	Clearance of HCV improves insulin resistance, beta-cell function, and hepatic expression of insulin receptor substrate 1 and 2.	IRS1 IRS2	1.03e-05	2	112	2	17222321
Pubmed	Stat5 promotes metastatic behavior of human prostate cancer cells in vitro and in vivo.	STAT5A STAT5B	1.03e-05	2	112	2	20233708
Pubmed	Insulin receptor substrate-1/2 mediates IL-4-induced migration of human airway epithelial cells.	IRS1 IRS2	1.03e-05	2	112	2	19447894
Pubmed	Involvement of the STAT5 signaling pathway in the regulation of mouse preimplantation development.	STAT5A STAT5B	1.03e-05	2	112	2	16775227
Pubmed	A Mouse Model to Assess STAT3 and STAT5A/B Combined Inhibition in Health and Disease Conditions.	STAT5A STAT5B	1.03e-05	2	112	2	31443474
Pubmed	STAT5 isoforms: controversies and clarifications.	STAT5A STAT5B	1.03e-05	2	112	2	17447893
Pubmed	Interleukin-2 family cytokines stimulate phosphorylation of the Pro-Ser-Pro motif of Stat5 transcription factors in human T cells: resistance to suppression of multiple serine kinase pathways.	STAT5A STAT5B	1.03e-05	2	112	2	12377952
Pubmed	Divergent roles for IRS-1 and IRS-2 in breast cancer metastasis.	IRS1 IRS2	1.03e-05	2	112	2	17361103
Pubmed	Disruption of IRS-2 causes type 2 diabetes in mice.	IRS1 IRS2	1.03e-05	2	112	2	9495343
Pubmed	Phosphorylation of insulin receptor substrates (IRS-1 and IRS-2) is attenuated following cecal ligation and puncture in mice.	IRS1 IRS2	1.03e-05	2	112	2	37550630
Pubmed	Insulin receptor substrate 1, but not IRS2, plays a dominant role in regulating pancreatic alpha cell function in mice.	IRS1 IRS2	1.03e-05	2	112	2	33839150
Pubmed	Roles of Insulin Receptor Substrates (IRS) in renal function and renal hemodynamics.	IRS1 IRS2	1.03e-05	2	112	2	33270683
Pubmed	A novel Ncr1-Cre mouse reveals the essential role of STAT5 for NK-cell survival and development.	STAT5A STAT5B	1.03e-05	2	112	2	21127177
Pubmed	The gammac-cytokine regulated transcription factor, STAT5, increases HIV-1 production in primary CD4 T cells.	STAT5A STAT5B	1.03e-05	2	112	2	16289657
Pubmed	Inhibition of Stat5a/b Enhances Proteasomal Degradation of Androgen Receptor Liganded by Antiandrogens in Prostate Cancer.	STAT5A STAT5B	1.03e-05	2	112	2	25552366
Pubmed	Deletion of STAT5a/b in vascular smooth muscle abrogates the male bias in hypoxic pulmonary hypertension in mice: implications in the human disease.	STAT5A STAT5B	1.03e-05	2	112	2	25470773
Pubmed	Plakins in development and disease.	EPPK1 PLEC	1.03e-05	2	112	2	17499243
Pubmed	Roles of insulin receptor substrates in insulin-induced stimulation of renal proximal bicarbonate absorption.	IRS1 IRS2	1.03e-05	2	112	2	15975995
Pubmed	Systematic modeling for the insulin signaling network mediated by IRS(1) and IRS(2).	IRS1 IRS2	1.03e-05	2	112	2	24703981
Pubmed	Differential hepatic distribution of insulin receptor substrates causes selective insulin resistance in diabetes and obesity.	IRS1 IRS2	1.03e-05	2	112	2	27708333
Pubmed	Constitutively active Stat5A and Stat5B promote adipogenesis.	STAT5A STAT5B	1.03e-05	2	112	2	21431790
Pubmed	Activation of signal transducer and activator of transcription-5 in prostate cancer predicts early recurrence.	STAT5A STAT5B	1.03e-05	2	112	2	16115927
Pubmed	Sequential activation of genetic programs in mouse mammary epithelium during pregnancy depends on STAT5A/B concentration.	STAT5A STAT5B	1.03e-05	2	112	2	23275557
Pubmed	Stat5 Is Required for CD103+ Dendritic Cell and Alveolar Macrophage Development and Protection from Lung Injury.	STAT5A STAT5B	1.03e-05	2	112	2	28500076
Pubmed	STAT5 isoforms regulate colorectal cancer cell apoptosis via reduction of mitochondrial membrane potential and generation of reactive oxygen species.	STAT5A STAT5B	1.03e-05	2	112	2	21826656
Pubmed	Impairment of bone healing by insulin receptor substrate-1 deficiency.	IRS1 IRS2	1.03e-05	2	112	2	14736890
Pubmed	Granulocyte-macrophage colony-stimulating factor (GM-CSF)-induced STAT5 activation and target-gene expression during human monocyte/macrophage differentiation.	STAT5A STAT5B	1.03e-05	2	112	2	11867689
Pubmed	Interleukin-3, granulocyte-macrophage colony stimulating factor and interleukin-5 transduce signals through two STAT5 homologs.	STAT5A STAT5B	1.03e-05	2	112	2	7720707
Pubmed	Evidence for lifespan extension and delayed age-related biomarkers in insulin receptor substrate 1 null mice.	IRS1 IRS2	1.03e-05	2	112	2	17928362
Pubmed	Global analysis of IL-2 target genes: identification of chromosomal clusters of expressed genes.	STAT5A STAT5B	1.03e-05	2	112	2	15980098
Pubmed	Impaired insulin signaling in endothelial cells reduces insulin-induced glucose uptake by skeletal muscle.	IRS1 IRS2	1.03e-05	2	112	2	21356519
Pubmed	STAT5A and STAT5B have opposite correlations with drug response gene expression.	STAT5A STAT5B	1.03e-05	2	112	2	27264955
Pubmed	The study on the relationship between IRS-1 Gly972Arg and IRS-2 Gly1057Asp polymorphisms and type 2 diabetes in the Kurdish ethnic group in West Iran.	IRS1 IRS2	1.03e-05	2	112	2	22994406
Pubmed	Inactivation of Stat5 in mouse mammary epithelium during pregnancy reveals distinct functions in cell proliferation, survival, and differentiation.	STAT5A STAT5B	1.03e-05	2	112	2	15340066
Pubmed	Nongenomic STAT5-dependent effects on Golgi apparatus and endoplasmic reticulum structure and function.	STAT5A STAT5B	1.03e-05	2	112	2	22159083
Pubmed	Caspase-mediated Cleavage of Insulin Receptor Substrate.	IRS1 IRS2	1.03e-05	2	112	2	15069074
Pubmed	STAT5 requires the N-domain for suppression of miR15/16, induction of bcl-2, and survival signaling in myeloproliferative disease.	STAT5A STAT5B	1.03e-05	2	112	2	20008792
Pubmed	The Irs1 branch of the insulin signaling cascade plays a dominant role in hepatic nutrient homeostasis.	IRS1 IRS2	1.03e-05	2	112	2	19596788
Pubmed	STAT5 Regulation of Sex-Dependent Hepatic CpG Methylation at Distal Regulatory Elements Mapping to Sex-Biased Genes.	STAT5A STAT5B	1.03e-05	2	112	2	33199496
Pubmed	A nuclear complex of rictor and insulin receptor substrate-2 is associated with albuminuria in diabetic mice.	RICTOR IRS2	1.03e-05	2	112	2	20545557
Pubmed	STAT5A/B gene locus undergoes amplification during human prostate cancer progression.	STAT5A STAT5B	1.03e-05	2	112	2	23660011
Pubmed	Role of Stat5 in type I interferon-signaling and transcriptional regulation.	STAT5A STAT5B	1.03e-05	2	112	2	12901872
Pubmed	Insulin receptor substrate (IRS)-2, not IRS-1, protects human neuroblastoma cells against apoptosis.	IRS1 IRS2	1.03e-05	2	112	2	19259821
Pubmed	Lack of insulin receptor substrate-2 causes progressive neointima formation in response to vessel injury.	IRS1 IRS2	1.03e-05	2	112	2	12810606
Pubmed	Overexpression of insulin receptor substrate-1, but not insulin receptor substrate-2, protects a T cell hybridoma from activation-induced cell death.	IRS1 IRS2	1.03e-05	2	112	2	12055235
Pubmed	Role of allelic variants Gly972Arg of IRS-1 and Gly1057Asp of IRS-2 in moderate-to-severe insulin resistance of women with polycystic ovary syndrome.	IRS1 IRS2	1.03e-05	2	112	2	11522686
Pubmed	Association of IRS1 (Gly972Arg) and IRS2 (Gly1057Asp) genes polymorphisms with OSA and NAFLD in Asian Indians.	IRS1 IRS2	1.03e-05	2	112	2	34449768
Pubmed	O-GlcNAcylation of STAT5 controls tyrosine phosphorylation and oncogenic transcription in STAT5-dependent malignancies.	STAT5A STAT5B	1.03e-05	2	112	2	28074064
Pubmed	STAT5b: A master regulator of key biological pathways.	STAT5A STAT5B	1.03e-05	2	112	2	36755813
Pubmed	Irs1 serine 307 promotes insulin sensitivity in mice.	IRS1 IRS2	1.03e-05	2	112	2	20074531
Pubmed	Role of IRS-2 in insulin and cytokine signalling.	IRS1 IRS2	1.03e-05	2	112	2	7675087
Pubmed	The influence of STAT5 antisense oligodeoxynucleotides on the proliferation and apoptosis of selected human cutaneous T-cell lymphoma cell lines.	STAT5A STAT5B	1.03e-05	2	112	2	16502315
Pubmed	Selective insulin resistance with differential expressions of IRS-1 and IRS-2 in human NAFLD livers.	IRS1 IRS2	1.03e-05	2	112	2	29717275
Pubmed	Increased expression of the sterol regulatory element-binding protein-1 gene in insulin receptor substrate-2(-/-) mouse liver.	IRS1 IRS2	1.03e-05	2	112	2	11546755
Pubmed	Stat5: an essential regulator of mast cell biology.	STAT5A STAT5B	1.03e-05	2	112	2	12217382
Pubmed	Identification of isoform-specific dynamics in phosphorylation-dependent STAT5 dimerization by quantitative mass spectrometry and mathematical modeling.	STAT5A STAT5B	1.03e-05	2	112	2	25333863
Pubmed	Increased insulin resistance in obese children who have both 972 IRS-1 and 1057 IRS-2 polymorphisms.	IRS1 IRS2	1.03e-05	2	112	2	12475767
Pubmed	A role for STAT5 in the pathogenesis of IL-2-induced glucocorticoid resistance.	STAT5A STAT5B	1.03e-05	2	112	2	12421978
Pubmed	A single amino acid in the DNA binding regions of STAT5A and STAT5B confers distinct DNA binding specificities.	STAT5A STAT5B	1.03e-05	2	112	2	9852045
Pubmed	Variations in insulin secretion in carriers of gene variants in IRS-1 and -2.	IRS1 IRS2	1.03e-05	2	112	2	11872698
Pubmed	Brain STAT5 Modulates Long-Term Metabolic and Epigenetic Changes Induced by Pregnancy and Lactation in Female Mice.	STAT5A STAT5B	1.03e-05	2	112	2	31599926
Pubmed	Essential role of insulin receptor substrate 1 (IRS-1) and IRS-2 in adipocyte differentiation.	IRS1 IRS2	1.03e-05	2	112	2	11259600
Pubmed	Signal transducer and activator of transcription (STAT)-5A and STAT5B differentially regulate human mammary carcinoma cell behavior.	STAT5A STAT5B	1.03e-05	2	112	2	19966185
Pubmed	Signal transducer and activator of transcription 5a/b: biomarker and therapeutic target in prostate and breast cancer.	STAT5A STAT5B	1.03e-05	2	112	2	21704724
Pubmed	DNA binding site selection of dimeric and tetrameric Stat5 proteins reveals a large repertoire of divergent tetrameric Stat5a binding sites.	STAT5A STAT5B	1.03e-05	2	112	2	10594041
Pubmed	Relationship of insulin receptor substrate-1 and -2 genotypes to phenotypic features of polycystic ovary syndrome.	IRS1 IRS2	1.03e-05	2	112	2	12213887
Pubmed	Association of IRS-1 and IRS-2 genes polymorphisms with polycystic ovary syndrome: a meta-analysis.	IRS1 IRS2	1.03e-05	2	112	2	22523112
Pubmed	Mitochondrial translocation of signal transducer and activator of transcription 5 (STAT5) in leukemic T cells and cytokine-stimulated cells.	STAT5A STAT5B	1.03e-05	2	112	2	21036145
Pubmed	Selective Insulin Resistance in the Kidney.	IRS1 IRS2	1.03e-05	2	112	2	27247938
Pubmed	Stimulation of lipolysis but not of leptin release by growth hormone is abolished in adipose tissue from Stat5a and b knockout mice.	STAT5A STAT5B	1.03e-05	2	112	2	10486277
Pubmed	Decreased lactation capacity and altered milk composition in insulin receptor substrate null mice is associated with decreased maternal body mass and reduced insulin-dependent phosphorylation of mammary Akt.	IRS1 IRS2	1.03e-05	2	112	2	17641282
Pubmed	Night-Shift Work Duration and Risk of Colorectal Cancer According to IRS1 and IRS2 Expression.	IRS1 IRS2	1.03e-05	2	112	2	31666286
Pubmed	Differential involvement of insulin receptor substrate (IRS)-1 and IRS-2 in brain insulin signaling is associated with the effects on amyloid pathology in a mouse model of Alzheimer's disease.	IRS1 IRS2	1.03e-05	2	112	2	34537327
Pubmed	Association of Gly972Arg variant of insulin receptor subtrate-1 and Gly1057Asp variant of insulin receptor subtrate-2 with polycystic ovary syndrome in the Chinese population.	IRS1 IRS2	1.03e-05	2	112	2	25310961
Pubmed	Hyperactive STAT5 hijacks T cell receptor signaling and drives immature T cell acute lymphoblastic leukemia.	STAT5A STAT5B	1.03e-05	2	112	2	38618957
Pubmed	Identification of human STAT5-dependent gene regulatory elements based on interspecies homology.	STAT5A STAT5B	1.03e-05	2	112	2	16840779
Pubmed	The role of the STAT5 proteins in the proliferation and apoptosis of the CML and AML cells.	STAT5A STAT5B	1.03e-05	2	112	2	15128421
Pubmed	STAT5 deficiency in hepatocytes reduces diethylnitrosamine-induced liver tumorigenesis in mice.	STAT5A STAT5B	1.03e-05	2	112	2	30377054
Pubmed	Gain-of-function of Stat5 leads to excessive granulopoiesis and lethal extravasation of granulocytes to the lung.	STAT5A STAT5B	1.03e-05	2	112	2	23565285
Pubmed	Assessment of STAT5 as a potential therapy target in enzalutamide-resistant prostate cancer.	STAT5A STAT5B	1.03e-05	2	112	2	32790723
Pubmed	Characterization and cloning of STAT5 from IM-9 cells and its activation by growth hormone.	STAT5A STAT5B	1.03e-05	2	112	2	8732682
Pubmed	In vivo identification of novel STAT5 target genes.	STAT5A STAT5B	1.03e-05	2	112	2	18492722
Pubmed	How Intrinsic Molecular Dynamics Control Intramolecular Communication in Signal Transducers and Activators of Transcription Factor STAT5.	STAT5A STAT5B	1.03e-05	2	112	2	26717567
Pubmed	Distinctive roles of STAT5a and STAT5b in sexual dimorphism of hepatic P450 gene expression. Impact of STAT5a gene disruption.	STAT5A STAT5B	1.03e-05	2	112	2	10066807
Pubmed	sh- Ambra1 inhibits IRS-1/PI3K/Akt signalling pathway to reduce autophagy in gestational diabetes.	AMBRA1 IRS1	1.03e-05	2	112	2	38497391
Pubmed	Molecular characterization of STAT5A- and STAT5B-encoding genes reveals extended intragenic sequence homogeneity in cattle and mouse and different degrees of divergent evolution of various domains.	STAT5A STAT5B	1.03e-05	2	112	2	10835485
Pubmed	Loss of Adipocyte STAT5 Confers Increased Depot-Specific Adiposity in Male and Female Mice That Is Not Associated With Altered Adipose Tissue Lipolysis.	STAT5A STAT5B	1.03e-05	2	112	2	35464049
Pubmed	Insulin Receptor Substrate Adaptor Proteins Mediate Prognostic Gene Expression Profiles in Breast Cancer.	IRS1 IRS2	1.03e-05	2	112	2	26991655
Pubmed	Overexpression of IRS2 in isolated pancreatic islets causes proliferation and protects human beta-cells from hyperglycemia-induced apoptosis.	IRS1 IRS2	1.03e-05	2	112	2	15572028
Interaction	TOP3B interactions	CAD EPPK1 MAN2A2 RTEL1 CENPF INPP5E GEMIN5 AMBRA1 IRS1 RHOT2 TPCN1 CCDC88C C2CD3 NADSYN1 MDN1 NFKB2 KBTBD11 IRS2 LRRC14 PLEC HERC1 SPEN CNOT1 MED12	1.00e-06	1470	110	24	int:TOP3B
Cytoband	2p22-p21	CAD THUMPD2	1.64e-04	8	112	2	2p22-p21
Cytoband	20p11.2	APMAP CRNKL1	3.20e-04	11	112	2	20p11.2
Cytoband	18q12	DTNA FHOD3	4.52e-04	13	112	2	18q12
Cytoband	Xq13	OGT MED12	4.52e-04	13	112	2	Xq13
Cytoband	Xq26.3	SMIM10L2A SAGE2P SMIM10L2B	6.04e-04	67	112	3	Xq26.3
Cytoband	4p16.1	MAN2B2 GPR78 HMX1	9.77e-04	79	112	3	4p16.1
Cytoband	5q35	GRM6 SLIT3	1.44e-03	23	112	2	5q35
Cytoband	8q24	TG PLEC	2.14e-03	28	112	2	8q24
Cytoband	7q22	ZAN GNB2	3.92e-03	38	112	2	7q22
Cytoband	4p14	CHRNA9 NWD2	4.77e-03	42	112	2	4p14
GeneFamily	Mannosidases alpha class 2	MAN2A2 MAN2B2	1.73e-04	5	76	2	1194
GeneFamily	PDZ domain containing	FRMPD4 ARHGAP23 PDZD7 SHROOM4 FRMPD3	4.49e-04	152	76	5	1220
GeneFamily	EF-hand domain containing\|Plakins	EPPK1 PLEC	4.80e-04	8	76	2	939
GeneFamily	Fucosyltransferases\|Blood group antigens	FUT11 POFUT2	1.32e-03	13	76	2	434
ToppCell	PND03-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial-Mesothelial_G2M\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MXD3 ZAN CENPF GRM6 TBX18 FRMPD3 TNXB	3.24e-07	178	111	7	c77a1d1a9aef0ab51b4408b9e84f201219788ca2
ToppCell	Tracheal-NucSeq-Stromal-Myofibroblastic\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	DTNA SYNE1 FHOD3 SLITRK3 PGM5 NID1 CACNA2D3	6.63e-07	198	111	7	c12e7511628db819a52959bb68580e27c00c2e41
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_4-Exc_L4-5_RORB_LCN15\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CENPF SPATA18 OCA2 PTGFRN NWD2 SLIT3	4.49e-06	171	111	6	6a489a75eeab2a2d48d604682e93599c20a945fe
ToppCell	TCGA-Brain-Primary_Tumor-Low_Grade_Glioma\|TCGA-Brain / Sample_Type by Project: Shred V9	ACADSB SYNE1 RICTOR ELFN2 MDN1 HERC1	5.48e-06	177	111	6	e8ab340b20cd41554c3841fe980e078e878af35f
ToppCell	droplet-Spleen-nan-21m-Lymphocytic-immature_NKT_cell\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MXD3 CENPF RHOT2 TTC34 SLC12A5 SMIM10L2B	5.84e-06	179	111	6	dabecd283c1f0f71a66b804c99be8bd48ea36e35
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	COL15A1 TBX18 RIMS4 SLIT3 NID1 TNXB	6.84e-06	184	111	6	e061e85c4bb19f49f6451ddd7a9077d7378ee365
ToppCell	Cerebellum-Neuronal\|Cerebellum / BrainAtlas - Mouse McCarroll V32	SMIM10L2A HCN3 FHOD3 SLC12A5 RIMS4 UNC80	7.50e-06	187	111	6	61b9d6eb131a674598aa8409d7fa909c8765442d
ToppCell	LPS-IL1RA-Stromal_mesenchymal-Lung_smooth_muscle-Myofibroblast\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DTNA SYNE1 FHOD3 IRS1 PGM5 NID1	7.73e-06	188	111	6	3177b2c1723268d330d3e9f24f9e24492ace6286
ToppCell	Globus_pallidus-Neuronal\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	CARMIL2 FRMPD4 TMEM91 SLC12A5 RIMS4 UNC80	8.21e-06	190	111	6	416de85d8841dac883faa6f5339b2fb461a09e82
ToppCell	368C-Lymphocytic-NK_cells-NK_cell_D3\|NK_cells / Donor, Lineage, Cell class and subclass (all cells)	THUMPD2 MVB12A GLS IRS2 CNOT1 SLC16A8	8.46e-06	191	111	6	d7920f4a602b50d0ef064eb47001e71939695ed2
ToppCell	Control-Stromal_mesenchymal\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DTNA FHOD3 PGM5 NWD2 SLIT3 TNXB	8.46e-06	191	111	6	14057205ddb9b4bbc582d1358d13cf36d979a61b
ToppCell	droplet-Pancreas-Exocrine-18m-Endothelial-nan\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL15A1 CENPF PTGFRN PGM5 NID1 TNXB	8.72e-06	192	111	6	a42aed9e563f5f4af029b8804c104f11ad227a8f
ToppCell	Posterior_cortex-Neuronal\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	CARMIL2 SMIM10L2A SLITRK3 SLC12A5 HERC1 UNC80	8.98e-06	193	111	6	b4989e3436e84dbec3789b46057e0f7a0ebf09d4
ToppCell	Tracheal-NucSeq-Stromal-Myofibroblastic-Muscle_smooth_pulmonary\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	DTNA SYNE1 SLITRK3 PGM5 NID1 CACNA2D3	1.01e-05	197	111	6	ac4f53acb2f8a428b0f2fab3c30a34e095a1bed7
ToppCell	droplet-Limb_Muscle-MUSCLE-1m-Mesenchymal-nan\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL15A1 VGLL2 PTGFRN NID1 POFUT2 TNXB	1.04e-05	198	111	6	5e70246a9ce199cb2fb5379912b8ab59456219e4
ToppCell	Somatosensory_Cortex_(S1)-Neuronal\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	FRMPD4 SYNE1 SLC12A5 GLS UNC80 CACNA2D3	1.04e-05	198	111	6	c01091ef18e096d792ea2a7a715764a5b215355f
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	FRMPD4 SYNE1 SLC12A5 GLS UNC80 CACNA2D3	1.04e-05	198	111	6	8ab40fae14fe02e39bc8c8da187a5cd60c787643
ToppCell	Tracheal-NucSeq-Stromal-Myofibroblastic-Muscle_smooth_airway_ASM\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	DTNA SYNE1 FHOD3 SLITRK3 PGM5 CACNA2D3	1.04e-05	198	111	6	22e766df1276c5b14aa0d83f434f47140ebb98ea
ToppCell	Neuronal\|World / cells hierarchy compared to all cells using T-Statistic	FRMPD4 SYNE1 SLC12A5 GLS HERC1 UNC80	1.10e-05	200	111	6	48d801219bc771d6c7e151dc88ca4c179988de85
ToppCell	Tracheal-NucSeq-Stromal-Fibroblastic-Fibro_peribronchial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	COL15A1 SYNE1 IRS1 NID1 TNXB CACNA2D3	1.10e-05	200	111	6	58b38f9a484ee94191091a0659ed62ebed2d4a14
ToppCell	PBMC-Severe-Myeloid-cDC-cDC-cDC_1\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	VGLL2 DTNA PTGFRN RIMS4 CACNA2D3	4.62e-05	157	111	5	e9d0300361b06aec3c216f8af15f09e14b12a4da
ToppCell	PBMC-Severe-Myeloid-cDC-cDC-cDC_1\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	VGLL2 DTNA PTGFRN RIMS4 CACNA2D3	4.76e-05	158	111	5	e9657d8960d499832f9f9b45b5a6f4388551b7e1
ToppCell	facs-Pancreas-Exocrine-18m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GEMIN5 SLITRK3 STAT5A UBP1 SLC16A8	5.52e-05	163	111	5	132aece9c79499b4bb3c2bde68d3d7202e1d8772
ToppCell	facs-Limb_Muscle-forelimb_and_hindlimb-18m-Lymphocytic-T_cell\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CARMIL2 RTEL1 RHOT2 GRM6 KBTBD11	6.37e-05	168	111	5	182f08106ac65ea501e2fb9139d3b44b7c4662c9
ToppCell	TCGA-Thryoid-Primary_Tumor-Thyroid_Papillary_Carcinoma-Classical-8\|TCGA-Thryoid / Sample_Type by Project: Shred V9	ARHGAP23 SMIM10L2A SHROOM4 FUT11 SLIT3	6.37e-05	168	111	5	00646601548b0fee42ae16bfa5e93603bc7c5129
ToppCell	severe_influenza-gd_T\|World / disease group, cell group and cell class (v2)	APMAP SYNE1 ELFN2 SLC12A5 PKP3	6.55e-05	169	111	5	6d514dd2d1e5253bce49279f43aa2fa2b7c2653e
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_4\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CENPF SPATA18 OCA2 PTGFRN NWD2	6.92e-05	171	111	5	f648789e6aefe508bb748401bf9b3cd830fb0ddf
ToppCell	390C-Lymphocytic-CD4_T-cell-CD4+_Effector_T_cell-2\|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)	PKP3 CRACDL RIN2 SLIT3 ALDH1B1	7.31e-05	173	111	5	b9dee61973559e8c2fef3f2dafd43475b386befb
ToppCell	droplet-Thymus-nan-21m-Lymphocytic-Double_negative_thymocyte,_DN3_(Cd8-,_Cd4-),_some_express_pre_TCR_alpha\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IRS1 ACOT6 ELFN2 ALDH1B1 UNC80	7.52e-05	174	111	5	a9f34d1237f335d27c5560ff514368f4709f9144
ToppCell	droplet-Thymus-nan-21m-Lymphocytic-DN3_thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IRS1 ACOT6 ELFN2 ALDH1B1 UNC80	7.93e-05	176	111	5	d43d9e86c4d4fa1e88fbf2b899ac7143717aac90
ToppCell	kidney_cells-Adult_normal_reference-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ARHGAP23 PGM5 KBTBD11 NID1 TNXB	8.15e-05	177	111	5	227d4f423b00be2e0c5797e2c5275d342e69a0f4
ToppCell	kidney_cells-Adult_normal_reference-Endothelial-lymphatic_endothelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ARHGAP23 PGM5 KBTBD11 NID1 TNXB	8.15e-05	177	111	5	66ffa279147961080c104242a08b176e301d80e3
ToppCell	facs-Brain_Myeloid-Striatum-24m-Myeloid-macrophage\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ARHGAP23 RHOT2 NADSYN1 PLEC ALDH1B1	8.15e-05	177	111	5	f6b9d91d46830d0d207b0abd4ee5a4942fd99774
ToppCell	kidney_cells-Adult_normal_reference-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex-lymphatic_endothelial_cell_of_renal_cortex\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ARHGAP23 PGM5 KBTBD11 NID1 TNXB	8.15e-05	177	111	5	0cbf54608d2ba0a0500af142f2029fe5e118c3c2
ToppCell	E16.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1-AF1_G2M\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CENPF RICTOR PGM5 ALDH1B1 CNOT1	8.37e-05	178	111	5	c87945146b2734141f07b39d268e0d8086ee0364
ToppCell	Control-Stromal_mesenchymal-Matrix_Fibroblast-MatrixFB\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	FHOD3 PGM5 NWD2 SLIT3 TNXB	8.82e-05	180	111	5	08ae0f5d95c45feba68ad99788f7af7ff4c979af
ToppCell	Control-Stromal_mesenchymal-Matrix_Fibroblast\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	FHOD3 PGM5 NWD2 SLIT3 TNXB	8.82e-05	180	111	5	9b1de1b4711adbf9a423f4d2d08f3f4c78f1f8f4
ToppCell	MS-Treg-naive_CD4\|MS / Condition, Cell_class and T cell subcluster	CENPF INPP5E AMBRA1 THUMPD2 POFUT2	8.82e-05	180	111	5	7ca083616926d98420fa11a6e5ebc981623f79ac
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_D_(IT_RORB_THEMIS_LINC00507)_6-Exc_L6_THEMIS_LINC00343\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	TG NWD2 CRACDL SLIT3 MACIR	9.29e-05	182	111	5	cc6f9d606a4f8717dc44928ceec2a257636043fd
ToppCell	LPS_only-Stromal_mesenchymal-Lung_smooth_muscle-Myofibroblast\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DTNA SYNE1 IRS1 PGM5 NID1	1.00e-04	185	111	5	e64e8c98dd88d91f6501d3fb10b60fd2f3c90af3
ToppCell	metastatic_Lymph_Node-Endothelial_cells-Tumor_ECs\|metastatic_Lymph_Node / Location, Cell class and cell subclass	COL15A1 PPFIA3 PGM5 SHROOM4 NID1	1.05e-04	187	111	5	2713f526f86911fbbf6c7a3e69230f2e6bde31c3
ToppCell	10x5'-GI_small-bowel-Lymphocytic_T_CD4-T_CD4/CD8\|GI_small-bowel / Manually curated celltypes from each tissue	RICTOR GLS HERC1 SPEN NIPBL	1.08e-04	188	111	5	ab9b725d6e0cdab8e9ddda6dee09e14730e9a578
ToppCell	droplet-Lung-LUNG-1m-Mesenchymal-adventitial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL15A1 PDZD7 SLIT3 NID1 TNXB	1.11e-04	189	111	5	f0a2d4ef9896d764971ebbc6952510c128bb76e8
ToppCell	droplet-Lung-LUNG-1m-Mesenchymal-Adventitial_Fibroblast\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL15A1 PDZD7 SLIT3 NID1 TNXB	1.11e-04	189	111	5	378f26f751ab4b470948c35dd8347de72dd12ff7
ToppCell	3'-Adult-LargeIntestine-Mesenchymal-myocytic-myofibroblast_(RSPO2+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	COL15A1 FRMPD4 DTNA PGM5 TBX18	1.11e-04	189	111	5	63449d9f1e78ff2bc8786eb88a0d177fe30c7f4d
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	NWD2 CRACDL GLS SLIT3 CACNA2D3	1.14e-04	190	111	5	49e09cdb843b3d889a06a811aa5affae68b25a75
ToppCell	facs-Trachea-3m-Mesenchymal-fibroblast\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	COL15A1 PTGFRN SLIT3 NID1 TNXB	1.19e-04	192	111	5	321850b0f881420c2d57d3e825e365c82fa511ab
ToppCell	facs-Pancreas-Exocrine-3m-Mesenchymal-pancreatic_stellate_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL15A1 PTGFRN SLIT3 NID1 TNXB	1.19e-04	192	111	5	8937a59f6bbe07f671bdabbd3707dc9c17a14cd9
ToppCell	facs-Pancreas-Exocrine-3m-Mesenchymal\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL15A1 PTGFRN SLIT3 NID1 TNXB	1.19e-04	192	111	5	e4a7f2673f801b008ca67291db2fb2b9fd2955b8
ToppCell	Entopeduncular-Neuronal\|Entopeduncular / BrainAtlas - Mouse McCarroll V32	FHOD3 TMEM91 SLC12A5 RIMS4 UNC80	1.19e-04	192	111	5	4c35e5c28a40b439044797ba1f06cb7c36b2a8de
ToppCell	facs-Pancreas-Exocrine-3m-Mesenchymal-pancreatic_stellate_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL15A1 PTGFRN SLIT3 NID1 TNXB	1.19e-04	192	111	5	ac1477433704573f95111eee6263b93668d2845e
ToppCell	facs-Trachea-3m-Mesenchymal-fibroblast-fibroblast_of_trachea\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	COL15A1 PTGFRN SLIT3 NID1 TNXB	1.19e-04	192	111	5	cf2765d8bc074f7f9ee864eae632a3b705175842
ToppCell	facs-Brain_Non-Myeloid-Cortex-24m-Neuronal\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLITRK3 PPFIA3 SLC12A5 CRACDL UNC80	1.22e-04	193	111	5	be28070c049e7cb68bcd54f582226eb2f5e4bc1c
ToppCell	droplet-Fat-Scat-18m-Mesenchymal-Cd34+\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL15A1 PTGFRN SLIT3 NID1 TNXB	1.22e-04	193	111	5	316ebdf15f75d88c348f909b643fcd315364ca84
ToppCell	droplet-Fat-Scat-18m-Mesenchymal-mesenchymal_stem_cell_of_adipose\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL15A1 PTGFRN SLIT3 NID1 TNXB	1.22e-04	193	111	5	1afdd3f7d703f4204a2cbfe40e135ac7b09213f7
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	TBX18 RIMS4 SLIT3 NID1 TNXB	1.22e-04	193	111	5	09a9ab029f01234459a88e3e994fe90ef4cbb8c6
ToppCell	facs-Brain_Non-Myeloid-Cortex-24m-Neuronal-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLITRK3 PPFIA3 SLC12A5 CRACDL UNC80	1.22e-04	193	111	5	0c652ebe22ce5d2927599dd97ef1920547858395
ToppCell	facs-Brain_Non-Myeloid-Cortex-24m-Neuronal-neuron\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLITRK3 PPFIA3 SLC12A5 CRACDL UNC80	1.22e-04	193	111	5	8689a70a33a7c3823dc647d41ac0160e7c3ae396
ToppCell	droplet-Fat-Scat-18m-Mesenchymal\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL15A1 PTGFRN SLIT3 NID1 TNXB	1.22e-04	193	111	5	8dc6db335678f3a5cfd36026ad811fed8d9cb4bc
ToppCell	Hippocampus-Neuronal\|Hippocampus / BrainAtlas - Mouse McCarroll V32	PPFIA3 SLC12A5 GLS HERC1 UNC80	1.25e-04	194	111	5	8aeb347b3024354c9505f4f0fddf0b843489dc6b
ToppCell	LPS-antiTNF-Stromal_mesenchymal\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DTNA SYNE1 PGM5 SLIT3 NID1	1.25e-04	194	111	5	6e13549f697f7478b34fe71f7dd9d63c5d3db22e
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	COL15A1 TBX18 SLIT3 NID1 TNXB	1.28e-04	195	111	5	803f714d91f2d97ecbee8c15a5139fd9310f66c7
ToppCell	3'-Pediatric_IBD-SmallIntestine-Mesenchymal-myocytic-myofibroblast\|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract	DTNA IRS1 PGM5 NID1 ALDH1B1	1.28e-04	195	111	5	eb2003d4f15cad213d17eda8ab7479f5a0c62164
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	COL15A1 TBX18 SLIT3 NID1 TNXB	1.28e-04	195	111	5	4f70157d42a16ff0259bc24a62803c4df4285c44
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	FRMPD4 SYNE1 SLC12A5 GLS UNC80	1.31e-04	196	111	5	676c56b44ac29f7baecb62f49bb8597cc74c0a88
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	COL15A1 DTNA TBX18 SLIT3 NID1	1.31e-04	196	111	5	1522958a92e0126326a9f0d9fb1c5b5c50b001ea
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	COL15A1 DTNA TBX18 SLIT3 NID1	1.31e-04	196	111	5	1c8294014713684b50885e638668f2ce75f357f0
ToppCell	Parenchymal-NucSeq-Stromal-Myofibroblastic\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	COL15A1 DTNA TBX18 SLIT3 NID1	1.38e-04	198	111	5	bd42c03e384e64f61b02618cf1a5440033bb04b2
ToppCell	primary_auditory_cortex_(A1C)-Neuronal\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	FRMPD4 SYNE1 SLC12A5 GLS UNC80	1.38e-04	198	111	5	6d18b45eda4014759e6dd282d78ffd28df8a6044
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	COL15A1 SYNE1 MDN1 SLIT3 NID1	1.38e-04	198	111	5	a860246bcea847249a78fd2e86ed8e04371060db
ToppCell	facs-Trachea-nan-3m-Mesenchymal-fibroblast\|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL15A1 PTGFRN SLIT3 NID1 TNXB	1.38e-04	198	111	5	0dc7d59a07428a7b7e8bdc81f0e2417dd4ce3cf2
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	FRMPD4 SYNE1 SLC12A5 GLS UNC80	1.38e-04	198	111	5	4ca5ff320905ab4ff60ed90a5522227c782142a6
ToppCell	droplet-Limb_Muscle-MUSCLE-1m-Mesenchymal-mesenchymal_stem_cell\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL15A1 PTGFRN NID1 POFUT2 TNXB	1.38e-04	198	111	5	1b90d632e59c3c47b936e829cceeb0334f05f34f
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	FRMPD4 SLC12A5 GLS HERC1 UNC80	1.38e-04	198	111	5	0ff30edfd3c133a42e8cb96e1631a1143215f808
ToppCell	mild-low-quality_cells\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	OGT SYNE1 RICTOR GLS HERC1	1.41e-04	199	111	5	f0b0097df0026496470a80d8cc9375ffd8389b00
ToppCell	Tracheal-NucSeq-Stromal-Peri/Epineurial_\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	ELFN2 TBX18 NID1 TNXB CACNA2D3	1.41e-04	199	111	5	3835452e4848d7f7dd8651c17b746b271ef39688
ToppCell	Tracheal-NucSeq-Stromal-Peri/Epineurial_-NAF_epineurial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	ELFN2 TBX18 NID1 TNXB CACNA2D3	1.41e-04	199	111	5	9c2db0bb94cba71a3cc1827844da090e213e0258
ToppCell	LPS_IL1RA-Mesenchymal_myocytic-Myofibroblastic\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	SYNE1 IRS1 PGM5 NID1 TNXB	1.44e-04	200	111	5	87827041663013f5e7273168dc8709d69840e7ce
ToppCell	Tracheal-10x3prime_v2-Stromal-Peri/Epineurial_-NAF_epineurial\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	CAD ARHGAP23 TBX18 NID1 TNXB	1.44e-04	200	111	5	24e13b6d9d2d8b29df1f02544ea9c50084d9e75c
Drug	Pyrimethamine [58-14-0]; Down 200; 16uM; MCF7; HT_HG-U133A	MXD3 DTNA RHOT2 PPFIA3 STAT5B TPCN1 CCDC88C POFUT2	5.41e-06	196	111	8	4779_DN
Drug	Buspirone hydrochloride [33386-08-2]; Down 200; 9.4uM; MCF7; HT_HG-U133A	MXD3 INPP5E IL17RC C2CD3 ERI3 GLS ALDH1B1 MED12	5.62e-06	197	111	8	5343_DN
Drug	Quinacrine dihydrochloride dihydrate [6151-30-0]; Down 200; 7.8uM; HL60; HG-U133A	CAD OGT RHOT2 TMEM177 MTMR4 KBTBD11 CACNA2D3	3.60e-05	186	111	7	1563_DN
Drug	Glibenclamide [10238-21-8]; Down 200; 8uM; HL60; HG-U133A	RHOT2 NADSYN1 LRRC14 TMEM109 NIPBL MED12 CACNA2D3	4.55e-05	193	111	7	1546_DN
Drug	Gossypol [303-45-7]; Down 200; 7.8uM; HL60; HT_HG-U133A	MXD3 ACADSB CENPF RHOT2 TRIM14 GLS PLEC	4.55e-05	193	111	7	2202_DN
Drug	15d-PGJ2; Down 200; 10uM; MCF7; HT_HG-U133A	MXD3 MAN2A2 DTNA PPFIA3 RIN2 LRRC14 MED12	4.86e-05	195	111	7	5228_DN
Drug	Chlorprothixene hydrochloride [6469-93-8]; Down 200; 11.4uM; MCF7; HT_HG-U133A	RTEL1 DTNA TRIM14 RIN2 LRRC14 PLEC ALDH1B1	5.02e-05	196	111	7	2627_DN
Drug	2-propylpentanoic acid; Down 200; 1000uM; MCF7; HT_HG-U133A	MXD3 CAD OGT RTEL1 RHOT2 TMEM177 IRS2	5.19e-05	197	111	7	1634_DN
Drug	Oxethazaine [126-27-2]; Down 200; 8.6uM; MCF7; HT_HG-U133A	DTNA KATNB1 RHOT2 TRIM14 STAT5B PLEC MED12	5.19e-05	197	111	7	4829_DN
Drug	Bromocryptine mesylate [22260-51-1]; Down 200; 5.4uM; MCF7; HT_HG-U133A	INPP5E RHOT2 PPFIA3 PKP3 NFKB2 IRS2 PLEC	5.19e-05	197	111	7	1507_DN
Drug	Clorgyline hydrochloride [17780-75-5]; Down 200; 13uM; MCF7; HT_HG-U133A	ACADSB CENPF AMBRA1 IL17RC PLEC ALDH1B1 POFUT2	5.36e-05	198	111	7	3219_DN
Drug	Denatonium benzoate [3734-33-6]; Down 200; 9uM; MCF7; HT_HG-U133A	MXD3 AMBRA1 RHOT2 PPFIA3 TRIM14 RIN2 NFKB2	5.36e-05	198	111	7	6502_DN
Drug	minocycline; Down 200; 10.5uM; MCF7; HT_HG-U133A_EA	EPPK1 STAT5B TPCN1 GLS SPEN POFUT2 MED12	5.36e-05	198	111	7	1135_DN
Drug	DO 897/99; Down 200; 8.2uM; MCF7; HT_HG-U133A	RTEL1 SLC12A5 TPCN1 KBTBD11 LRRC14 POFUT2 NIPBL	5.36e-05	198	111	7	2877_DN
Drug	Carcinine [56897-53-1]; Down 200; 22uM; HL60; HT_HG-U133A	DTNA SYNE1 AMBRA1 PDZD7 STAT5B CRNKL1 NIPBL	5.53e-05	199	111	7	1305_DN
Drug	SC 19220; Down 200; 10uM; MCF7; HT_HG-U133A	RTEL1 CENPF DTNA KATNB1 TRIM14 IRS2 ALDH1B1	5.53e-05	199	111	7	7090_DN
Disease	blood vanadium measurement	GPR78 HMX1 TBX18	1.85e-04	30	109	3	EFO_0021533
Disease	Combined immunodeficiency	CARMIL2 STAT5A STAT5B	4.72e-04	41	109	3	C0494261
Disease	Prostatic Neoplasms	COL15A1 CENPF SPATA18 IRS1 IL17RC PKP3 SPEN MED12 MACIR	4.75e-04	616	109	9	C0033578
Disease	Malignant neoplasm of prostate	COL15A1 CENPF SPATA18 IRS1 IL17RC PKP3 SPEN MED12 MACIR	4.75e-04	616	109	9	C0376358
Disease	amnestic disorder (implicated_via_orthology)	IRS1 IRS2	4.79e-04	9	109	2	DOID:10914 (implicated_via_orthology)
Disease	type 2 diabetes mellitus (implicated_via_orthology)	OGT IRS1 CCKAR IRS2	6.32e-04	105	109	4	DOID:9352 (implicated_via_orthology)
Disease	Basal cell carcinoma	XPA STAT5B	7.28e-04	11	109	2	C0007117
Disease	hepatocellular carcinoma (implicated_via_orthology)	CAD SAV1 SMAD2	7.98e-04	49	109	3	DOID:684 (implicated_via_orthology)
Disease	basal cell carcinoma (is_implicated_in)	OCA2 CRNKL1	8.71e-04	12	109	2	DOID:2513 (is_implicated_in)
Disease	lymphangioleiomyomatosis (is_marker_for)	RICTOR GLS	8.71e-04	12	109	2	DOID:3319 (is_marker_for)
Disease	uterine fibroid	RTEL1 SYNE1 SPATA18 ELFN2 MTMR4	8.79e-04	199	109	5	EFO_0000731
Disease	Polydactyly	CENPF INPP5E BBS1 C2CD3	9.48e-04	117	109	4	C0152427
Disease	central nervous system cancer, glioblastoma multiforme	RTEL1 SLC16A8	1.20e-03	14	109	2	EFO_0000326, EFO_0000519
Disease	obesity (implicated_via_orthology)	BBS1 IRS1 CCKAR ALDH1B1 MED12	1.24e-03	215	109	5	DOID:9970 (implicated_via_orthology)
Disease	CCL2 measurement	MXD3 KCNQ4 KBTBD11 CACNA2D3	1.25e-03	126	109	4	EFO_0004749
Disease	platelet component distribution width	SYNE1 SAV1 IRS1 NOL4L RIN2 IRS2 PLEC HERC1 TNXB	1.97e-03	755	109	9	EFO_0007984
Disease	Malignant neoplasm of breast	NPBWR1 CENPF SYNE1 SPATA18 OCA2 GRM6 STAT5A SPEN NIPBL MED12 MACIR	2.10e-03	1074	109	11	C0006142
Disease	anorectal malformation	RTEL1 PKP3	2.22e-03	19	109	2	MONDO_0019938
Disease	triacylglycerol 58:9 measurement	NFKB2 TNXB	2.98e-03	22	109	2	EFO_0010443
Disease	osteoporosis (biomarker_via_orthology)	IRS1 IRS2	2.98e-03	22	109	2	DOID:11476 (biomarker_via_orthology)
Disease	Granulomatous Slack Skin	STAT5B NFKB2	2.98e-03	22	109	2	C0376407
Disease	Lymphoma, T-Cell, Cutaneous	STAT5B NFKB2	3.25e-03	23	109	2	C0079773
Disease	electrocardiography	VGLL2 FHOD3 RHOT2 KCNQ4 KBTBD11 PLEC CNOT1	3.58e-03	530	109	7	EFO_0004327

Protein segments in the cluster

Peptide	Gene	Start	Entry
GAARFSSYLLSRARK	ERI3	86	O43414
LGSRDLALSVAALSY	CARMIL2	201	Q6F5E8
SLQGRTARYSSAAAL	ALDH1B1	11	P30837
SSRGLCEYRASLLAG	ACOT6	166	Q3I5F7
ARLLTYNAARLLEAG	ACADSB	346	P45954
AASRLRAAETADGKY	CHRNA9	16	Q9UGM1
YSLVLELSDSGAFRR	APMAP	361	Q9HDC9
RAYDTASAERRLSGT	CCKAR	336	P32238
SSLISLSRYDGAGSR	AMBRA1	696	Q9C0C7
LRLAYSAAAAHSRGL	DMRTA2	466	Q96SC8
SALRRAAFSGNLTAL	NWD2	16	Q9ULI1
RRYLLSREVSGLSAS	OCA2	136	Q04671
AYTGDVSALRRFALS	GLS	561	O94925
RNAERTATAGRLLYD	INTS10	51	Q9NVR2
GLTDLSSARARSYGA	SLC16A8	331	O95907
SSSGVRATLRLYAES	PGM5	511	Q15124
YSLVERRLGDRALSS	PCDHA11	491	Q9Y5I1
SGADLSRLDLRYINF	KCTD9	226	Q7L273
YLQRGLSLDRAFSEA	MDN1	2376	Q9NU22
LFLSGSKRYLSDLAR	LEXM	376	Q3ZCV2
ALAYRLTDLGSRLLS	MAP10	176	Q9P2G4
LGADCARYTTLSLLR	MXD3	86	Q9BW11
RSYLEGSLLASGALL	INPP5E	271	Q9NRR6
SGLDSLGRYRSSCSL	PPFIA3	641	O75145
ALLSRFSDSYSQARL	SPATA18	301	Q8TC71
YALSGRRNVDLDLAA	HERC1	1526	Q15751
ARTLLARAAGLYRSV	HERC1	2886	Q15751
LLGFYSRCLRSGTSA	KCNQ4	636	P56696
EYLLASGSSDRTIRF	KATNB1	201	Q9BVA0
LSRAFSLASADLLRA	CCDC88C	1801	Q9P219
YRLSEQDGSFSLARI	ITGAE	551	P38570
LDAGLARSSRLYKTR	MACIR	96	Q96GV9
LGSDSGSTATRYLLR	PDZD7	31	Q9H5P4
ALELSGALRFYDRSD	NID1	56	P14543
RYLSSAERAGLAASL	HMX1	226	Q9NP08
FSREELTGYLLRASA	RASGRP4	516	Q8TDF6
RVASLDYLGTVAARL	NIPBL	1606	Q6KC79
RSDGSSAERCILAYL	MED12	961	Q93074
VAFSRSGRLLLAGYD	GNB2	276	P62879
LARGARDTRLTDGSY	HCN3	476	Q9P1Z3
LSTSSGRLLYAATAD	IRS1	791	P35568
IAGYRESAAFLLRSA	NOL4L	411	Q96MY1
AYSAELRTRASGVLL	GPR78	31	Q96P69
AAGLRALRYLIQDSS	RICTOR	101	Q6R327
TVSSLDYSRDGLARV	RICTOR	701	Q6R327
LRSTSLSLKYRDGAS	CRACDL	686	Q6NV74
GSRASTLRRNDSIYE	MVB12A	191	Q96EY5
GRAADALIAISNYRL	MTMR4	46	Q9NYA4
YRALTDLVSEGRAAA	IRS2	136	Q9Y4H2
AYERGLSLDSFLRAS	RBBP8NL	256	Q8NC74
LELRSYSLAGRHGST	CRNKL1	26	Q9BZJ0
LGARLLDTCSRDTYA	GRM6	91	O15303
AYVDLARLGERSART	C2CD3	1516	Q4AC94
SLSSLGDSSFYRALL	CENPF	1486	P49454
SRGASALLAAALLYA	CACNA2D3	11	Q8IZS8
GDYASVRTALLAARA	FAM151A	546	Q8WW52
RARSYTLDNSLGAEA	FRMPD3	626	Q5JV73
DYRSLAQRSLLTLSG	FRMPD4	621	Q14CM0
ALRDSRTRALLFYGT	FUT11	111	Q495W5
YNSSGRDLRRALFSL	FHOD3	116	Q2V2M9
LYSLAAAHARRSGLA	MAN2A2	531	P49641
SSLKGLARRASALLY	MAN2B2	366	Q9Y2E5
LIARYAARLAAESSS	DTNA	436	Q9Y4J8
LRAARAYLQALESSL	BBS1	461	Q8NFJ9
ARAAGLLSTYRAFLS	COL15A1	1241	P39059
RSGAAARGRAALLLY	IL17RC	576	Q8NAC3
ARGRAALLLYSADDS	IL17RC	581	Q8NAC3
RVAGRTYSAARAVSL	NPBWR1	146	P48145
FDRAVAAYLRALSLS	OGT	241	O15294
DGIRGLSLSAARYAL	SLC12A5	666	Q9H2X9
RLDTVGSDAYRLSVS	PTGFRN	221	Q9P2B2
GSDAYRLSVSRALSA	PTGFRN	226	Q9P2B2
RLSVSRALSADQGSY	PTGFRN	231	Q9P2B2
SAYLADARRALGSAG	RTEL1	1061	Q9NZ71
SRLSLSASFEALAIY	RIMS4	6	Q9H426
YSLSRFRLLTGSLEA	SYNE1	7151	Q8NF91
LRRFGYSDALELTAD	RHOT2	271	Q8IXI1
SAADILSGAASRRRY	POFUT2	31	Q9Y2G5
TDAFAGTSLARLNLR	SLITRK3	521	O94933
ASGYVSRAAREELLA	EPPK1	2541	P58107
LASGYVSRAAREELL	EPPK1	3076	P58107
LASGYVSRAAREELL	EPPK1	4141	P58107
VRLSRSAAARGSYGA	SMIM10L2A	21	P0DMW4
VRLSRSAAARGSYGA	SMIM10L2B	21	P0DMW5
DLSSYRAISSLDLLG	SHROOM4	1011	Q9ULL8
FSIRSLADRLGDLNY	STAT5B	651	P51692
LTALRLLLADAYSGR	KBTBD11	181	O94819
FSIRSLADRLGDLSY	STAT5A	651	P42229
DATSGADADLLLRYR	CNOT1	1671	A5YKK6
GSRADYDTLSLRSLR	PKP3	171	Q9Y446
AGLSSVRLLSLYDNR	SLIT3	626	O75094
NRLSAPSYLARSLAD	SAV1	91	Q9H4B6
GYDSLSNRLSILDRL	RIN2	76	Q8WYP3
LRREGLAESTSQAAY	UNC80	2781	Q8N2C7
SVDSARRYSLCGASL	VGLL2	301	Q8N8G2
SALYESSRLSFLLRD	SPEN	1396	Q96T58
LAEAGILATSTRDLY	SAGE2P	371	A6NJ88
ARSGLTLNRYSTSLA	TBX18	421	O95935
LYSFSEQTRSLDGRL	SMAD2	101	Q15796
CSSIKAGRRSSYLLA	ARHGAP23	601	Q9P227
GRYRLSTRSDLSLGS	SNX18	191	Q96RF0
HSAVLRDLRSGTLYS	TNXB	3716	P22105
ALLRAVVRSYDSGSF	GEMIN5	1226	Q8TEQ6
LASRAYIKTAGLRST	THUMPD2	271	Q9BTF0
IDRSALDQYRAGTLS	PLEC	4351	Q15149
RLSRSSALASKATGY	CAD	686	P27708
YALLSRLTGSRASGA	TMEM109	196	Q9BVC6
YASLRRRGASAAARL	TRIM14	341	Q14142
LYREARGASSDVTRL	TPCN1	726	Q9ULQ1
AADGIRLYNSLKSRS	UBP1	411	Q9NZI7
ARLAARPYSATAAAA	XPA	41	P23025
LDRRTASLSAAYACG	TMEM177	231	Q53S58
FLRGSDYAIRLAAQS	TG	986	P01266
ASRLLAADALYRLGR	TTC34	51	A8MYJ7
AAALVTLAAYLASRD	TMEM91	156	Q6ZNR0
TRGSTAYLDIALDAL	ZAN	181	Q9Y493
NRLSRLDGATFASLA	ELFN2	161	Q5R3F8
ASYAFLREALRSSVG	LRRC14	176	Q15048
YRAEISSRNLAASRA	NADSYN1	281	Q6IA69
RSARALLDYGVTADA	NFKB2	456	Q00653