Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionprotein sequestering activity

LRRC15 SMAD6

7.59e-0434242GO:0140311
GeneOntologyMolecularFunctiontranslation initiation factor activity

EIF3B EIF4E2

1.70e-0351242GO:0003743
GeneOntologyMolecularFunctionnuclear retinoic acid receptor binding

PRAMEF6 PRAMEF5

1.98e-0355242GO:0042974
GeneOntologyMolecularFunctionmolecular sequestering activity

LRRC15 SMAD6

2.27e-0359242GO:0140313
GeneOntologyMolecularFunctionubiquitin-like ligase-substrate adaptor activity

PRAMEF6 PRAMEF5

4.34e-0382242GO:1990756
GeneOntologyMolecularFunctiontranslation factor activity, RNA binding

EIF3B EIF4E2

4.65e-0385242GO:0008135
GeneOntologyMolecularFunctionenzyme-substrate adaptor activity

PRAMEF6 PRAMEF5

5.77e-0395242GO:0140767
DomainDUF3669_Znf

ZNF777 ZNF212 ZNF746

3.72e-086243IPR022137
DomainDUF3669

ZNF777 ZNF212 ZNF746

3.72e-086243PF12417
DomainPRAME_family

PRAMEF6 PRAMEF5

2.67e-0419242IPR026271
Domain-

PRAMEF6 LRRC15 PRAMEF5

7.79e-033212433.80.10.10
DomainL_dom-like

PRAMEF6 LRRC15 PRAMEF5

8.26e-03328243IPR032675
DomainKRAB

ZNF777 ZNF212 ZNF746

1.05e-02358243PS50805
DomainKRAB

ZNF777 ZNF212 ZNF746

1.05e-02358243PF01352
DomainKRAB

ZNF777 ZNF212 ZNF746

1.14e-02369243SM00349
DomainKRAB

ZNF777 ZNF212 ZNF746

1.15e-02370243IPR001909
Domain-

KCNT1 HSD11B2

1.97e-021692423.40.50.720
DomainNAD(P)-bd_dom

KCNT1 HSD11B2

2.06e-02173242IPR016040
Pubmed

DUF3669, a "domain of unknown function" within ZNF746 and ZNF777, oligomerizes and contributes to transcriptional repression.

ZNF777 ZNF746

2.74e-06424231856708
Pubmed

Differential expression of PRAMEL1, a cancer/testis antigen, during spermatogenesis in the mouse.

PRAMEF6 PRAMEF5

6.17e-051724223565261
Pubmed

Mouse Pramel1 regulates spermatogonial development by inhibiting retinoic acid signaling during spermatogenesis.

PRAMEF6 PRAMEF5

6.17e-051724237781892
Pubmed

Oocyte-specific gene Oog1 suppresses the expression of spermatogenesis-specific genes in oocytes.

PRAMEF6 PRAMEF5

6.94e-051824229731491
Pubmed

The promoter of the oocyte-specific gene, Oog1, functions in both male and female meiotic germ cells in transgenic mice.

PRAMEF6 PRAMEF5

6.94e-051824223894331
Pubmed

Identification of a new expanding family of genes characterized by atypical LRR domains. Localization of a cluster preferentially expressed in oocyte.

PRAMEF6 PRAMEF5

6.94e-051824214675769
Pubmed

Oogenesin is a novel mouse protein expressed in oocytes and early cleavage-stage embryos.

PRAMEF6 PRAMEF5

6.94e-051824212890732
Pubmed

Pramel15 facilitates zygotic nuclear DNMT1 degradation and DNA demethylation.

PRAMEF6 PRAMEF5

6.94e-051824239181896
Pubmed

Pramel7 mediates ground-state pluripotency through proteasomal-epigenetic combined pathways.

PRAMEF6 PRAMEF5

7.75e-051924228604677
Pubmed

Oog1, an oocyte-specific protein, interacts with Ras and Ras-signaling proteins during early embryogenesis.

PRAMEF6 PRAMEF5

8.61e-052024216580637
Pubmed

Pramel7 mediates LIF/STAT3-dependent self-renewal in embryonic stem cells.

PRAMEF6 PRAMEF5

8.61e-052024221425410
Pubmed

Preferentially Expressed Antigen in Melanoma (PRAME) and the PRAME Family of Leucine-Rich Repeat Proteins.

PRAMEF6 PRAMEF5

8.61e-052024226694250
Pubmed

Sertoli cell-only phenotype and scRNA-seq define PRAMEF12 as a factor essential for spermatogenesis in mice.

PRAMEF6 PRAMEF5

1.05e-042224231729367
Pubmed

Oogenesis specific genes (Nobox, Oct4, Bmp15, Gdf9, Oogenesin1 and Oogenesin2) are differentially expressed during natural and gonadotropin-induced mouse follicular development.

PRAMEF6 PRAMEF5

1.14e-042324219480014
Pubmed

MAGE-B4, a binding partner of PRAMEF12, is dispensable for spermatogenesis and male fertility in mice.

PRAMEF6 PRAMEF5

1.36e-042524237451217
Pubmed

Incomplete reactivation of Oct4-related genes in mouse embryos cloned from somatic nuclei.

PRAMEF6 PRAMEF5

1.36e-042524212620990
Pubmed

Expression profiling in transgenic FVB/N embryonic stem cells overexpressing STAT3.

PRAMEF6 PRAMEF5

1.47e-042624218500982
Pubmed

Differences in gene expression between mouse and human for dynamically regulated genes in early embryo.

PRAMEF6 PRAMEF5

1.71e-042824225089626
Pubmed

Thirteen Ovary-Enriched Genes Are Individually Not Essential for Female Fertility in Mice.

PRAMEF6 PRAMEF5

1.96e-043024238786026
Pubmed

LSM14B is essential for oocyte meiotic maturation by regulating maternal mRNA storage and clearance.

PRAMEF6 PRAMEF5

2.24e-043224237889087
Pubmed

Retinoic acid receptors are required for skeletal growth, matrix homeostasis and growth plate function in postnatal mouse.

PRAMEF6 PRAMEF5

2.68e-043524219389355
Pubmed

Mbd3, a component of the NuRD co-repressor complex, is required for development of pluripotent cells.

PRAMEF6 PRAMEF5

4.64e-044624217287250
Pubmed

DUX is a non-essential synchronizer of zygotic genome activation.

PRAMEF6 PRAMEF5

5.48e-045024231806660
InteractionZNF767P interactions

ZNF777 ZNF212 ZNF746

7.20e-0716233int:ZNF767P
InteractionZNF398 interactions

ZNF777 ZNF212 ZNF746

1.56e-0543233int:ZNF398
InteractionZNF212 interactions

ZNF777 ZNF212 ZNF746

2.31e-0549233int:ZNF212
InteractionZNF783 interactions

ZNF212 ZNF746

6.81e-0511232int:ZNF783
Cytoband7q36.1

ZNF777 ZNF212 ZNF746

7.94e-06742437q36.1
CytobandEnsembl 112 genes in cytogenetic band chr7q36

ZNF777 ZNF212 ZNF746

7.82e-05159243chr7q36
Cytoband1p36.21

PRAMEF6 PRAMEF5

5.02e-04632421p36.21
GeneFamilyPRAME family

PRAMEF6 PRAMEF5

2.27e-0424172686
GeneFamilyZinc fingers C2H2-type|ZF class homeoboxes and pseudogenes

ZNF777 ZNF212 ZNF746

2.80e-0271817328
CoexpressionGSE26343_WT_VS_NFAT5_KO_MACROPHAGE_LPS_STIM_DN

ZC3H6 LYST SCPEP1 DNAJC30 ZNF746

7.40e-07200235M8651
CoexpressionGSE17721_CPG_VS_GARDIQUIMOD_1H_BMDC_DN

COX18 EIF3B ZNF746 ACSL5

2.60e-05200234M3880
CoexpressionHUANG_GATA2_TARGETS_DN

PRAMEF6 PRAMEF5 TMEM132A

8.50e-0598233MM942
Diseasedisease recurrence, colon carcinoma

ZNF777 ZNF746

6.02e-0451212EFO_0004952, EFO_1001950
Diseaseamyotrophic lateral sclerosis

ZNF746 ACSL5

4.74e-03145212MONDO_0004976

Protein segments in the cluster

PeptideGeneStartEntry
QLLWRPRPPTLLSQE

EIF3B

701

P55884
RPLPALQLWARDLPL

COX18

11

Q8N8Q8
LIQDFSLQPRPWRKP

C2orf78

846

A6NCI8
LAALDWLCQRLLPPP

HSD11B2

41

P80365
LPFIITIFWPPLRNL

KCNT1

201

Q5JUK3
AIFLWLITRPQPVLP

ACSL5

26

Q9ULC5
LPPWARNDPRLFILI

LYST

3326

Q99698
SRPGLLWQLPLAPVF

FPGS

331

Q05932
RLLPWRLLQARGFPQ

DNAJC30

11

Q96LL9
RLGPQRLLFQNLWKP

EIF4E2

226

O60573
PPQLLLGRLFRWPDL

SMAD6

221

O43541
FLLLQPWPRAQPLLR

TMEM132A

81

Q24JP5
LLAWRVDPPFRPCLQ

RPS6KB2

336

Q9UBS0
ILPLRNWLLLNQPRL

LRRC15

431

Q8TF66
RRSPVPRWLLLLPLL

SCPEP1

6

Q9HB40
LLRPRLSPWGLAPLF

PRR14

236

Q9BWN1
VQAWPFRRLPLRPLI

PRAMEF6

56

Q5VXH4
PLPPLIADQRLNRLW

ZC3H6

901

P61129
VQAWPFRRLPLRPLI

PRAMEF5

56

Q5TYX0
PKPFSRWRNLQPALR

SLC28A1

56

O00337
NLLRNRNFWILRLPP

ZNF212

116

Q9UDV6
NLLRNRNFWILRLPP

ZNF746

86

Q6NUN9
PQPRPALWVLLFFLL

WNT10A

16

Q9GZT5
LLKNRNFWILRLPPG

ZNF777

261

Q9ULD5