Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	sodium-independent organic anion transmembrane transporter activity	SLCO1B7 SLC22A9 SLCO1A2	1.65e-05	18	56	3	GO:0015347
GeneOntologyMolecularFunction	secondary active transmembrane transporter activity	SLCO1B7 SLC22A9 SLC12A9 SLC18A2 SLCO1A2 SLC2A4 SLC17A6	1.82e-05	296	56	7	GO:0015291
GeneOntologyMolecularFunction	uniporter activity	SLC2A4 SLC17A6	3.43e-04	10	56	2	GO:0015292
GeneOntologyMolecularFunction	solute:monoatomic cation symporter activity	SLC12A9 SLC18A2 SLC2A4 SLC17A6	3.47e-04	119	56	4	GO:0015294
GeneOntologyMolecularFunction	active transmembrane transporter activity	SLCO1B7 SLC22A9 SLC12A9 SLC18A2 SLCO1A2 SLC2A4 SLC17A6	3.58e-04	477	56	7	GO:0022804
GeneOntologyMolecularFunction	transporter activity	SLCO1B7 SLC22A9 SLC12A9 SLC18A2 SLCO1A2 NPC1L1 CACHD1 SLC35F1 SVOPL SLC2A4 SLC17A6	7.84e-04	1289	56	11	GO:0005215
GeneOntologyMolecularFunction	symporter activity	SLC12A9 SLC18A2 SLC2A4 SLC17A6	8.30e-04	150	56	4	GO:0015293
GeneOntologyMolecularFunction	organic hydroxy compound transmembrane transporter activity	SLCO1B7 SLC18A2 SLCO1A2	1.00e-03	70	56	3	GO:1901618
GeneOntologyMolecularFunction	lipid transmembrane transporter activity	SLCO1B7 SLC22A9 SLCO1A2	1.13e-03	73	56	3	GO:0170055
GeneOntologyMolecularFunction	transmembrane transporter activity	SLCO1B7 SLC22A9 SLC12A9 SLC18A2 SLCO1A2 CACHD1 SLC35F1 SVOPL SLC2A4 SLC17A6	1.48e-03	1180	56	10	GO:0022857
GeneOntologyMolecularFunction	C-acyltransferase activity	ACAT2 SLC27A3	1.57e-03	21	56	2	GO:0016408
GeneOntologyMolecularFunction	chloride:monoatomic cation symporter activity	SLC12A9 SLC18A2	1.88e-03	23	56	2	GO:0015377
GeneOntologyMolecularFunction	monocarboxylic acid transmembrane transporter activity	SLCO1B7 SLC22A9 SLCO1A2	2.07e-03	90	56	3	GO:0008028
GeneOntologyMolecularFunction	lipid transporter activity	SLCO1B7 SLC22A9 SLCO1A2 NPC1L1	2.22e-03	196	56	4	GO:0005319
GeneOntologyMolecularFunction	monoatomic anion:monoatomic cation symporter activity	SLC12A9 SLC18A2	2.40e-03	26	56	2	GO:0015296
GeneOntologyMolecularFunction	carboxylic acid transmembrane transporter activity	SLCO1B7 SLC22A9 SLCO1A2 SLC17A6	2.70e-03	207	56	4	GO:0046943
GeneOntologyMolecularFunction	organic acid transmembrane transporter activity	SLCO1B7 SLC22A9 SLCO1A2 SLC17A6	2.75e-03	208	56	4	GO:0005342
GeneOntologyMolecularFunction	bile acid transmembrane transporter activity	SLCO1B7 SLCO1A2	4.09e-03	34	56	2	GO:0015125
GeneOntologyMolecularFunction	chloride transmembrane transporter activity	SLC12A9 SLC18A2 SLC17A6	5.21e-03	125	56	3	GO:0015108
GeneOntologyBiologicalProcess	sodium-independent organic anion transport	SLCO1B7 SLC22A9 SLCO1A2	7.98e-06	15	55	3	GO:0043252
Domain	MFS	SLCO1B7 SLC22A9 SLC18A2 SLCO1A2 SVOPL SLC2A4 SLC17A6	4.19e-08	108	58	7	PS50850
Domain	MFS_dom	SLCO1B7 SLC22A9 SLC18A2 SLCO1A2 SVOPL SLC2A4 SLC17A6	1.85e-07	134	58	7	IPR020846
Domain	Tetraspanin_CS	CD82 CD9 CD81 TSPAN14	4.82e-07	21	58	4	IPR018503
Domain	TM4_1	CD82 CD9 CD81 TSPAN14	1.19e-06	26	58	4	PS00421
Domain	Tetraspanin	CD82 CD9 CD81 TSPAN14	2.82e-06	32	58	4	IPR000301
Domain	Tetraspanin_EC2	CD82 CD9 CD81 TSPAN14	2.82e-06	32	58	4	IPR008952
Domain	Tetraspannin	CD82 CD9 CD81 TSPAN14	3.20e-06	33	58	4	PF00335
Domain	Tetraspanin/Peripherin	CD82 CD9 CD81 TSPAN14	3.20e-06	33	58	4	IPR018499
Domain	COX1	NDUFA4L2 MS4A12	5.66e-05	4	58	2	IPR000883
Domain	-	CD9 CD81	9.42e-05	5	58	2	1.10.1450.10
Domain	CD81_LEL	CD9 CD81	9.42e-05	5	58	2	IPR028977
Domain	MFS	SLC22A9 SLC18A2 SVOPL SLC17A6	9.57e-05	77	58	4	IPR011701
Domain	MFS_1	SLC22A9 SLC18A2 SVOPL SLC17A6	9.57e-05	77	58	4	PF07690
Domain	TLV_coat	ERVV-2 ERVV-1	1.97e-04	7	58	2	PF00429
Domain	TLV/ENV_coat_polyprotein	ERVV-2 ERVV-1	2.62e-04	8	58	2	IPR018154
Domain	OA_transporter	SLCO1B7 SLCO1A2	6.13e-04	12	58	2	IPR004156
Domain	OATP	SLCO1B7 SLCO1A2	6.13e-04	12	58	2	PF03137
Domain	-	RIMKLB PC	7.23e-04	13	58	2	3.40.50.20
Domain	ATP-grasp	RIMKLB PC	8.42e-04	14	58	2	IPR011761
Domain	PreATP-grasp_dom	RIMKLB PC	8.42e-04	14	58	2	IPR016185
Domain	ATP_GRASP	RIMKLB PC	8.42e-04	14	58	2	PS50975
Domain	-	RIMKLB PC	9.70e-04	15	58	2	3.30.1490.20
Domain	-	RIMKLB PC	1.40e-03	18	58	2	3.30.470.20
Domain	ATP_grasp_subdomain_1	RIMKLB PC	1.40e-03	18	58	2	IPR013815
Domain	ATP_grasp_subdomain_2	RIMKLB PC	4.16e-03	31	58	2	IPR013816
Domain	Sugar_tr	SVOPL SLC2A4	5.58e-03	36	58	2	PF00083
Domain	MFS_sugar_transport-like	SVOPL SLC2A4	5.58e-03	36	58	2	IPR005828
Domain	Kazal_2	SLCO1B7 SLCO1A2	5.58e-03	36	58	2	PF07648
Domain	PMP22_Claudin	CLDN18 CLDND2	6.85e-03	40	58	2	PF00822
Domain	-	IMPDH2 PC	7.54e-03	42	58	2	3.20.20.70
Domain	Aldolase_TIM	IMPDH2 PC	8.25e-03	44	58	2	IPR013785
Domain	PMP22/EMP/MP20/Claudin	CLDN18 CLDND2	8.61e-03	45	58	2	IPR004031
Domain	ER_TARGET	FKBP10 B3GLCT	9.37e-03	47	58	2	PS00014
Domain	KAZAL_2	SLCO1B7 SLCO1A2	1.06e-02	50	58	2	PS51465
Domain	Kazal_dom	SLCO1B7 SLCO1A2	1.10e-02	51	58	2	IPR002350
Pubmed	Tetraspanins regulate ADAM10-mediated cleavage of TNF-alpha and epidermal growth factor.	CD82 CD9 CD81	1.85e-08	4	59	3	18981120
Pubmed	Mapping of tetraspanin-enriched microdomains that can function as gateways for HIV-1.	CD82 CD9 CD81	1.85e-08	4	59	3	16735575
Pubmed	HIV-1 replication in dendritic cells occurs through a tetraspanin-containing compartment enriched in AP-3.	CD82 CD9 CD81	1.85e-08	4	59	3	18034776
Pubmed	Control of cell motility by interaction of gangliosides, tetraspanins, and epidermal growth factor receptor in A431 versus KB epidermoid tumor cells.	CD82 CD9 CD81	1.85e-08	4	59	3	19559406
Pubmed	Modulation of human immunodeficiency virus type 1 infectivity through incorporation of tetraspanin proteins.	CD82 CD9 CD81	4.63e-08	5	59	3	17989173
Pubmed	Role of Gag and lipids during HIV-1 assembly in CD4(+) T cells and macrophages.	CD82 CD9 CD81	4.63e-08	5	59	3	25009540
Pubmed	The major CD9 and CD81 molecular partner. Identification and characterization of the complexes.	CD82 CD9 CD81	9.24e-08	6	59	3	11278880
Pubmed	CD19 is linked to the integrin-associated tetraspans CD9, CD81, and CD82.	CD82 CD9 CD81	9.24e-08	6	59	3	9804823
Pubmed	TspanC8 tetraspanins differentially regulate the cleavage of ADAM10 substrates, Notch activation and ADAM10 membrane compartmentalization.	CD9 CD81 TSPAN14	2.58e-07	8	59	3	26686862
Pubmed	CD46 (membrane cofactor protein) associates with multiple beta1 integrins and tetraspans.	CD82 CD9 CD81	2.58e-07	8	59	3	10741407
Pubmed	TspanC8 tetraspanins regulate ADAM10/Kuzbanian trafficking and promote Notch activation in flies and mammals.	CD9 CD81 TSPAN14	5.52e-07	10	59	3	23091066
Pubmed	ADAM-mediated ectodomain shedding of HB-EGF in receptor cross-talk.	CD82 CD9 CD81	7.58e-07	11	59	3	16054021
Pubmed	Selective tetraspan-integrin complexes (CD81/alpha4beta1, CD151/alpha3beta1, CD151/alpha6beta1) under conditions disrupting tetraspan interactions.	CD82 CD9 CD81	1.01e-06	12	59	3	10229664
Pubmed	Mapping of the genes for four members of the transmembrane 4 superfamily: mouse Cd9, Cd63, Cd81, and Cd82.	CD82 CD9 CD81	1.67e-06	14	59	3	7590978
Pubmed	Tetraspanin-induced death of myeloma cell lines is autophagic and involves increased UPR signalling.	CD82 CD81	2.83e-06	2	59	2	19755988
Pubmed	Double deletion of tetraspanins CD9 and CD81 in mice leads to a syndrome resembling accelerated aging.	CD9 CD81	2.83e-06	2	59	2	29572511
Pubmed	Hepatocyte CD81 is required for Plasmodium falciparum and Plasmodium yoelii sporozoite infectivity.	CD9 CD81	2.83e-06	2	59	2	12483205
Pubmed	Infertility of CD9-deficient mouse eggs is reversed by mouse CD9, human CD9, or mouse CD81; polyadenylated mRNA injection developed for molecular analysis of sperm-egg fusion.	CD9 CD81	2.83e-06	2	59	2	12086470
Pubmed	CD81 and CD82 expressing tumor-infiltrating lymphocytes in the NSCLC tumor microenvironment play a crucial role in T-cell activation and cytokine production.	CD82 CD81	2.83e-06	2	59	2	38515751
Pubmed	Increased NPC1L1 and ACAT2 expression in the jejunal mucosa from Chinese gallstone patients.	ACAT2 NPC1L1	2.83e-06	2	59	2	19071091
Pubmed	CD81 interacts with the T cell receptor to suppress signaling.	CD9 CD81	2.83e-06	2	59	2	23226274
Pubmed	Tetraspanins regulate the protrusive activities of cell membrane.	CD82 CD81	2.83e-06	2	59	2	22079629
Pubmed	Deletion of tetraspanin CD9 diminishes lymphangiogenesis in vivo and in vitro.	CD9 CD81	2.83e-06	2	59	2	23223239
Pubmed	CD9 and CD81 Interactions and Their Structural Modelling in Sperm Prior to Fertilization.	CD9 CD81	2.83e-06	2	59	2	29671763
Pubmed	Tetraspanin blockage reduces exosome-mediated HIV-1 entry.	CD9 CD81	2.83e-06	2	59	2	29429034
Pubmed	CD82 and Gangliosides Tune CD81 Membrane Behavior.	CD82 CD81	2.83e-06	2	59	2	34445169
Pubmed	Small extracellular vesicles have distinct CD81 and CD9 tetraspanin expression profiles in plasma from rheumatoid arthritis patients.	CD9 CD81	2.83e-06	2	59	2	36826611
Pubmed	Expression of KAI1/CD82 and MRP-1/CD9 in transitional cell carcinoma of bladder.	CD82 CD9	2.83e-06	2	59	2	17393117
Pubmed	Double deficiency of tetraspanins CD9 and CD81 alters cell motility and protease production of macrophages and causes chronic obstructive pulmonary disease-like phenotype in mice.	CD9 CD81	2.83e-06	2	59	2	18662991
Pubmed	Hypoxic tumor cell modulates its microenvironment to enhance angiogenic and metastatic potential by secretion of proteins and exosomes.	CD9 CD81	2.83e-06	2	59	2	20124223
Pubmed	Reduced fertility of female mice lacking CD81.	CD9 CD81	2.83e-06	2	59	2	16380109
Pubmed	Vpu is the main determinant for tetraspanin downregulation in HIV-1-infected cells.	CD82 CD81	2.83e-06	2	59	2	25568205
Pubmed	The inner loop of tetraspanins CD82 and CD81 mediates interactions with human T cell lymphotrophic virus type 1 Gag protein.	CD82 CD81	2.83e-06	2	59	2	17166843
Pubmed	Differential evolutionary fate of an ancestral primate endogenous retrovirus envelope gene, the EnvV syncytin, captured for a function in placentation.	ERVV-2 ERVV-1	2.83e-06	2	59	2	23555306
Pubmed	Gene conversion and purifying selection of a placenta-specific ERV-V envelope gene during simian evolution.	ERVV-2 ERVV-1	2.83e-06	2	59	2	18826608
Pubmed	CD81 and CD9 work independently as extracellular components upon fusion of sperm and oocyte.	CD9 CD81	2.83e-06	2	59	2	23213457
Pubmed	Expression of CD9 and CD82 in clear cell renal cell carcinoma and its clinical significance.	CD82 CD9	2.83e-06	2	59	2	24553302
Pubmed	Lateral organization of membrane proteins: tetraspanins spin their web.	CD9 CD81	8.48e-06	3	59	2	19426143
Pubmed	Tetraspanins CD9 and CD81 modulate HIV-1-induced membrane fusion.	CD9 CD81	8.48e-06	3	59	2	17015697
Pubmed	A role for CD81 on the late steps of HIV-1 replication in a chronically infected T cell line.	CD82 CD81	8.48e-06	3	59	2	19284574
Pubmed	Mouse homologue of C33 antigen (CD82), a member of the transmembrane 4 superfamily: complementary DNA, genomic structure, and expression.	CD82 CD81	8.48e-06	3	59	2	8039242
Pubmed	Human immunodeficiency virus type 1 assembly, budding, and cell-cell spread in T cells take place in tetraspanin-enriched plasma membrane domains.	CD9 CD81	8.48e-06	3	59	2	17522207
Pubmed	CD63 is not required for production of infectious human immunodeficiency virus type 1 in human macrophages.	CD9 CD81	8.48e-06	3	59	2	18321974
Pubmed	The tetraspanin CD81 regulates the expression of CD19 during B cell development in a postendoplasmic reticulum compartment.	CD9 CD81	8.48e-06	3	59	2	14530327
Pubmed	Tetraspanins CD9 and CD81 are molecular partners of trimeric FcɛRI on human antigen-presenting cells.	CD9 CD81	8.48e-06	3	59	2	21241315
Pubmed	Resolution of de novo HIV production and trafficking in immature dendritic cells.	CD82 CD81	8.48e-06	3	59	2	18059278
Pubmed	Tetraspanin CD81 is required for the alpha v beta5-integrin-dependent particle-binding step of RPE phagocytosis.	CD9 CD81	8.48e-06	3	59	2	17684062
Pubmed	Down-regulation of TM4SF is associated with the metastatic potential of gastric carcinoma TM4SF members in gastric carcinoma.	CD82 CD9	8.48e-06	3	59	2	21521534
Pubmed	Tetraspanins regulate cell-to-cell transmission of HIV-1.	CD9 CD81	8.48e-06	3	59	2	19602278
Pubmed	Differential proteomics argues against a general role for CD9, CD81 or CD63 in the sorting of proteins into extracellular vesicles.	CD9 CD81	8.48e-06	3	59	2	37525398
Pubmed	FPRP, a major, highly stoichiometric, highly specific CD81- and CD9-associated protein.	CD9 CD81	8.48e-06	3	59	2	11087758
Pubmed	Formation of syncytia is repressed by tetraspanins in human immunodeficiency virus type 1-producing cells.	CD9 CD81	8.48e-06	3	59	2	19458002
Pubmed	Gag induces the coalescence of clustered lipid rafts and tetraspanin-enriched microdomains at HIV-1 assembly sites on the plasma membrane.	CD9 CD81	8.48e-06	3	59	2	21813604
Pubmed	Tetherin/BST-2 is essential for the formation of the intracellular virus-containing compartment in HIV-infected macrophages.	CD9 CD81	1.69e-05	4	59	2	22980332
Pubmed	The endocytic pathway: a mosaic of domains.	CD82 CD81	1.69e-05	4	59	2	11584299
Pubmed	Expression of tetraspanin adaptor proteins below defined threshold values is associated with in vitro invasiveness of mammary carcinoma cells.	CD82 CD9	1.69e-05	4	59	2	12579280
Pubmed	The CD9, CD81, and CD151 EC2 domains bind to the classical RGD-binding site of integrin αvβ3.	CD9 CD81	1.69e-05	4	59	2	27993971
Pubmed	HIV-1 assembly differentially alters dynamics and partitioning of tetraspanins and raft components.	CD9 CD81	1.69e-05	4	59	2	20727121
Pubmed	Organic anion transporting polypeptide 1a/1b-knockout mice provide insights into hepatic handling of bilirubin, bile acids, and drugs.	SLCO1B7 SLCO1A2	1.69e-05	4	59	2	20644253
Pubmed	Infectious HIV-1 assembles in late endosomes in primary macrophages.	CD82 CD81	1.69e-05	4	59	2	12885763
Pubmed	Selective enrichment of tetraspan proteins on the internal vesicles of multivesicular endosomes and on exosomes secreted by human B-lymphocytes.	CD82 CD81	1.69e-05	4	59	2	9685355
Pubmed	The transferrin receptor and the tetraspanin web molecules CD9, CD81, and CD9P-1 are differentially sorted into exosomes after TPA treatment of K562 cells.	CD9 CD81	1.69e-05	4	59	2	17407154
Pubmed	Gamma-glutamyl transpeptidase, an ecto-enzyme regulator of intracellular redox potential, is a component of TM4 signal transduction complexes.	CD82 CD81	1.69e-05	4	59	2	9862348
Pubmed	Local Mitochondrial ATP Production Regulates Endothelial Fatty Acid Uptake and Transport.	FIS1 SLC27A3	1.69e-05	4	59	2	32521232
Pubmed	Pharmacogenetics of OATP (SLC21/SLCO), OAT and OCT (SLC22) and PEPT (SLC15) transporters in the intestine, liver and kidney.	SLC22A9 SLCO1A2	1.69e-05	4	59	2	18466105
Pubmed	Role of transmembrane 4 superfamily (TM4SF) proteins CD9 and CD81 in muscle cell fusion and myotube maintenance.	CD9 CD81	1.69e-05	4	59	2	10459022
Pubmed	Tetraspanins CD9 and CD81 function to prevent the fusion of mononuclear phagocytes.	CD9 CD81	1.69e-05	4	59	2	12796480
Pubmed	Molecular analyses of the association of CD4 with two members of the transmembrane 4 superfamily, CD81 and CD82.	CD82 CD81	1.69e-05	4	59	2	7636191
Pubmed	CD81 controls sustained T cell activation signaling and defines the maturation stages of cognate immunological synapses.	CD9 CD81	1.69e-05	4	59	2	23858057
Pubmed	CD63 associates with transmembrane 4 superfamily members, CD9 and CD81, and with beta 1 integrins in human melanoma.	CD9 CD81	1.69e-05	4	59	2	8630057
Pubmed	Strategies for targeting tetraspanin proteins: potential therapeutic applications in microbial infections.	CD9 CD81	1.69e-05	4	59	2	19894777
Pubmed	Contribution of Organic Anion-Transporting Polypeptides 1A/1B to Doxorubicin Uptake and Clearance.	SLCO1B7 SLCO1A2	1.69e-05	4	59	2	27777271
Pubmed	C-kit associated with the transmembrane 4 superfamily proteins constitutes a functionally distinct subunit in human hematopoietic progenitors.	CD9 CD81	1.69e-05	4	59	2	12036870
Pubmed	The zebrafish fth1, slc3a2, men1, pc, fgf3 and cycd1 genes define two regions of conserved synteny between linkage group 7 and human chromosome 11q13.	CD81 PC	2.82e-05	5	59	2	11167010
Pubmed	CD9 controls the formation of clusters that contain tetraspanins and the integrin alpha 6 beta 1, which are involved in human and mouse gamete fusion.	CD9 CD81	2.82e-05	5	59	2	16418227
Pubmed	VGluT2 Expression in Dopamine Neurons Contributes to Postlesional Striatal Reinnervation.	SLC18A2 SLC17A6	2.82e-05	5	59	2	32928885
Pubmed	VMAT2-Mediated Neurotransmission from Midbrain Leptin Receptor Neurons in Feeding Regulation.	SLC18A2 SLC17A6	2.82e-05	5	59	2	28560316
Pubmed	The palmitoylation of metastasis suppressor KAI1/CD82 is important for its motility- and invasiveness-inhibitory activity.	CD82 CD9	2.82e-05	5	59	2	15492270
Pubmed	The CD9/CD81 tetraspanin complex and tetraspanin CD151 regulate α3β1 integrin-dependent tumor cell behaviors by overlapping but distinct mechanisms.	CD9 CD81	2.82e-05	5	59	2	23613949
Pubmed	Loci from a genome-wide analysis of bilirubin levels are associated with gallstone risk and composition.	SLCO1B7 SLCO1A2	2.82e-05	5	59	2	20837016
Pubmed	HIV-1 buds predominantly at the plasma membrane of primary human macrophages.	CD82 CD81	2.82e-05	5	59	2	17381240
Pubmed	Expression of transmembrane 4 superfamily (TM4SF) proteins and their role in hepatic stellate cell motility and wound healing migration.	CD9 CD81	2.82e-05	5	59	2	12175627
Pubmed	Supramolecular complexes of MHC class I, MHC class II, CD20, and tetraspan molecules (CD53, CD81, and CD82) at the surface of a B cell line JY.	CD82 CD81	2.82e-05	5	59	2	8816400
Pubmed	Tetraspanins CD81 and CD82 facilitate α4β1-mediated adhesion of human erythroblasts to vascular cell adhesion molecule-1.	CD82 CD81	2.82e-05	5	59	2	23704882
Pubmed	OATP1A/1B transporters affect irinotecan and SN-38 pharmacokinetics and carboxylesterase expression in knockout and humanized transgenic mice.	SLCO1B7 SLCO1A2	2.82e-05	5	59	2	24194565
Pubmed	Normal muscle regeneration requires tight control of muscle cell fusion by tetraspanins CD9 and CD81.	CD9 CD81	2.82e-05	5	59	2	23575678
Pubmed	Complete OATP1B1 and OATP1B3 deficiency causes human Rotor syndrome by interrupting conjugated bilirubin reuptake into the liver.	SLCO1B7 SLCO1A2	4.23e-05	6	59	2	22232210
Pubmed	Exosomal-like vesicles are present in human blood plasma.	CD9 CD81	4.23e-05	6	59	2	15908444
Pubmed	Dopaminergic neurons inhibit striatal output through non-canonical release of GABA.	SLC18A2 SLC17A6	4.23e-05	6	59	2	23034651
Pubmed	EWI-2 is a major CD9 and CD81 partner and member of a novel Ig protein subfamily.	CD9 CD81	4.23e-05	6	59	2	11504738
Pubmed	Proteomic and biochemical analysis of purified human immunodeficiency virus type 1 produced from infected monocyte-derived macrophages.	CD9 CD81	4.23e-05	6	59	2	16940516
Pubmed	Glycoprotein 90K, downregulated in advanced colorectal cancer tissues, interacts with CD9/CD82 and suppresses the Wnt/beta-catenin signal via ISGylation of beta-catenin.	CD82 CD9	4.23e-05	6	59	2	20581239
Pubmed	Lateral septum as a melanocortin downstream site in obesity development.	SLC18A2 SLC17A6	4.23e-05	6	59	2	37171957
Pubmed	Reactivation of codogenic endogenous retroviral (ERV) envelope genes in human endometrial carcinoma and prestages: Emergence of new molecular targets.	ERVV-2 ERVV-1	4.23e-05	6	59	2	23085571
Pubmed	Endocytosis, intracellular sorting, and processing of exosomes by dendritic cells.	CD9 CD81	5.91e-05	7	59	2	15284116
Pubmed	NAG-2, a novel transmembrane-4 superfamily (TM4SF) protein that complexes with integrins and other TM4SF proteins.	CD9 CD81	5.91e-05	7	59	2	9360996
Pubmed	Multimolecular signaling complexes enable Syk-mediated signaling of CD36 internalization.	CD9 CD81	5.91e-05	7	59	2	23395392
Pubmed	Identification of six putative human transporters with structural similarity to the drug transporter SLC22 family.	SLC22A9 SVOPL	7.87e-05	8	59	2	17714910
Pubmed	Syncytins expressed in human placental trophoblast.	ERVV-2 ERVV-1	7.87e-05	8	59	2	33504453
Pubmed	Critical role of PPAR-alpha in perfluorooctanoic acid- and perfluorodecanoic acid-induced downregulation of Oatp uptake transporters in mouse livers.	SLCO1B7 SLCO1A2	1.26e-04	10	59	2	18703564
Cytoband	3p21.2	LINC00696 IMPDH2	2.74e-04	19	59	2	3p21.2
Cytoband	17p13	NEURL4 SLC2A4	8.87e-04	34	59	2	17p13
Cytoband	9q31.1	OR13C9 OR13C2	1.29e-03	41	59	2	9q31.1
GeneFamily	Solute carriers	SLCO1B7 SLC22A9 SLC12A9 SLC18A2 SLCO1A2 SLC35F1 SLC2A4 SLC27A3 SLC17A6	7.50e-08	395	37	9	752
GeneFamily	CD molecules\|Tetraspanins	CD82 CD9 CD81 TSPAN14	5.82e-07	33	37	4	768
GeneFamily	Olfactory receptors, family 13	OR13C9 OR13C2	1.00e-03	23	37	2	162
GeneFamily	ADAM metallopeptidase domain containing\|CD molecules	CD82 CD9 LAMP3 CD81	8.32e-03	394	37	4	471
ToppCell	Bronchial-10x5prime-Stromal-Myofibroblastic-Muscle_smooth_systemic_arterial\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	SYNPO2 TMEM132E FRZB NDUFA4L2 LHFPL1 SLC2A4	2.43e-07	197	59	6	d1cb30ec4f3024541e9876c70bf63fe4d5c55bf1
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	SYNPO2 FRZB NDUFA4L2 LHFPL1 SLC2A4	1.78e-06	152	59	5	0cb5f4dfae04e3f4eba502bbf229007d5fa3884d
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell-\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	SYNPO2 FRZB NDUFA4L2 LHFPL1 SLC2A4	1.78e-06	152	59	5	ba89ffb5a8bb33c188f854f54b39123b6d73496a
ToppCell	primary_visual_cortex-Non-neuronal-smooth_muscle_cell-SMC\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	SYNPO2 CD82 CD9 NDUFA4L2 SLC2A4	2.58e-06	164	59	5	9eed945e9b0c1ee5fc62724ac2bbbed4267b0678
ToppCell	primary_visual_cortex-Non-neuronal-smooth_muscle_cell-SMC-SMC_Acta2\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	SYNPO2 CD82 CD9 NDUFA4L2 SLC2A4	2.58e-06	164	59	5	f510f20e37e31b486cdd0e3f597ce4ff00877c5d
ToppCell	primary_visual_cortex-Non-neuronal-smooth_muscle_cell\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	SYNPO2 CD82 CD9 NDUFA4L2 SLC2A4	2.58e-06	164	59	5	5c932a462cbf81d029c8d11ec3aea3191529527b
ToppCell	droplet-Lung-nan-21m-Lymphocytic-Natural_Killer_T_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CD82 CLDND2 TBX21 APLP1 LHFPL1	2.99e-06	169	59	5	18ba8fc2ba8838484d3b223428cd41568e2ccb10
ToppCell	droplet-Lung-nan-21m-Lymphocytic-mature_NK_T_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CD82 CLDND2 TBX21 APLP1 LHFPL1	2.99e-06	169	59	5	47a63afd80cb7ba2258ba57d3084d8b2a7bc4e8d
ToppCell	3'_v3-bone_marrow-Mast\|bone_marrow / Manually curated celltypes from each tissue	CD82 CD9 SLC18A2 SVOPL VAT1	4.07e-06	180	59	5	b37ee81b792213d6595b4ec65d04bc35d83321c7
ToppCell	facs-Brain_Non-Myeloid-Cortex-24m-Macroglial\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CD82 CD9 APLP1 CD81 FIS1	4.07e-06	180	59	5	350ba05cec45a788ab33530cc1346daddb00f884
ToppCell	3'_v3-bone_marrow-Mast-Mast_cells\|bone_marrow / Manually curated celltypes from each tissue	CD82 CD9 SLC18A2 SVOPL VAT1	4.19e-06	181	59	5	30ec4635474ee0f0ea1415ec0ba7f008d97e8c1a
ToppCell	facs-Brain_Non-Myeloid-Cortex-24m-Macroglial-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CD82 CD9 APLP1 CD81 FIS1	4.30e-06	182	59	5	0beffe6b9b36cfd196ec98a18f6ded080c162f90
ToppCell	facs-Brain_Non-Myeloid-Cortex-24m-Macroglial-oligodendrocyte\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CD82 CD9 APLP1 CD81 FIS1	4.42e-06	183	59	5	038edbc879db7bca795fb2f08e47c42476946161
ToppCell	IPF-Stromal-Pericyte\|World / Disease state, Lineage and Cell class	FKBP10 SYNPO2 FRZB NDUFA4L2 SLC2A4	5.87e-06	194	59	5	1a41da29d5adaf766a84eff0003b959e4523f7f1
ToppCell	3'-Broncho-tracheal-Mesenchymal-Mesenchymal_Myocytic-tracheobronchial_smooth_muscle_cell-Smooth_muscle-Smooth_muscle_L.2.3.0.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SYNPO2 FRZB NDUFA4L2 SLC35F1 SLC2A4	6.01e-06	195	59	5	bbafea2262074beede78e286276a1927ecb80582
ToppCell	3'-Broncho-tracheal-Mesenchymal-Mesenchymal_Myocytic-tracheobronchial_smooth_muscle_cell-Smooth_muscle\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SYNPO2 FRZB NDUFA4L2 SLC35F1 SLC2A4	6.01e-06	195	59	5	145c50fa60d9df162152be0a6c070213ebdb8119
ToppCell	Transplant_Alveoli_and_parenchyma-Mesenchymal-Smooth_muscle\|Mesenchymal / Tissue, Lineage and Cell class of Lung Cells from 10X	SYNPO2 CD9 FRZB NDUFA4L2 SLC2A4	6.48e-06	198	59	5	89986c7756541df364df516329d10775ba0e78a4
ToppCell	(2)_NK/T-(20)_NK_cell\|(2)_NK/T / immune cells in Peripheral Blood (logTPM normalization)	GZMA TBX21 CD81 TTC38 SLC27A3	6.48e-06	198	59	5	2e4851e49457940e841660c5d781499ffb4a2bf1
ToppCell	(2)_NK/T-(200)_CD56+_NK_cell\|(2)_NK/T / immune cells in Peripheral Blood (logTPM normalization)	GZMA TBX21 CD81 TTC38 SLC27A3	6.48e-06	198	59	5	03477a6356a3c08c6e723165c0aac3464ef01667
ToppCell	Tracheal-10x5prime-Stromal-Pericyte\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	SYNPO2 FRZB NDUFA4L2 SLC35F1 SLC2A4	6.64e-06	199	59	5	cefc3b50f65e95da850e4720c7b44bf584073491
ToppCell	3'-Child04-06-SmallIntestine-Mesenchymal-Pericytes-Pericyte\|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SYNPO2 FRZB NDUFA4L2 SLC35F1 SLC2A4	6.64e-06	199	59	5	bd9b36dcf61eaa628ce1b70d21c5783b64c29e8f
ToppCell	3'-Child04-06-SmallIntestine-Mesenchymal-Pericytes\|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SYNPO2 FRZB NDUFA4L2 SLC35F1 SLC2A4	6.64e-06	199	59	5	e751eb67510f8a5842dcfed44134160919cdb713
ToppCell	Tracheal-10x5prime-Stromal-Pericyte-Muscle_pericyte_systemic\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	SYNPO2 FRZB NDUFA4L2 SLC35F1 SLC2A4	6.64e-06	199	59	5	aaa460c389cd6d38a13ba1a446f91a94f9573ad8
ToppCell	Fetal_brain-fetalBrain_Zhong_nature-GW23-OPC_related\|GW23 / Sample Type, Dataset, Time_group, and Cell type.	FKBP10 CD82 B3GLCT CD9 SLC35F1	6.80e-06	200	59	5	439265194cb08d1373296bf8684cc31294cecb20
ToppCell	LPS_IL1RA-Mesenchymal_myocytic-Pericyte-Pericyte_3\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	SYNPO2 FRZB NDUFA4L2 SLC35F1 SLC2A4	6.80e-06	200	59	5	a3a1e35934d676c39f917652e50c502cb2f613c1
ToppCell	LPS_only-Mesenchymal_myocytic\|LPS_only / Treatment groups by lineage, cell group, cell type	SYNPO2 FRZB NDUFA4L2 SLC35F1 SLC2A4	6.80e-06	200	59	5	8bc9923f82bfb836e2f524204c92050edeae8ca5
ToppCell	Fetal_brain-fetalBrain_Zhong_nature-GW23-OPC_related-OPC\|GW23 / Sample Type, Dataset, Time_group, and Cell type.	FKBP10 CD82 B3GLCT CD9 SLC35F1	6.80e-06	200	59	5	0450a79c5fae5ccacdb990ae674e4734ef0c3691
ToppCell	PND14-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_ILC-NK-NK\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CD82 CLDND2 GZMA TBX21	3.89e-05	143	59	4	138033ff447a61a1bc289b21db82151dcc6a4c7e
ToppCell	Pericytes-IPF_04\|World / lung cells shred on cell class, cell subclass, sample id	SYNPO2 FRZB NDUFA4L2 CAMKMT	4.68e-05	150	59	4	dbc202bd6db4fb5c8b2abd1200e074a2a9e63a59
ToppCell	356C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_0.5\|356C / Donor, Lineage, Cell class and subclass (all cells)	GZMA PRPF38B TTC38 SVOPL	5.46e-05	156	59	4	7ccd20e3bbce6a070df45034b0bdc255f267efb1
ToppCell	facs-Lung-EPCAM-24m-Lymphocytic-Natural_Killer\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CD82 BEND6 GZMA TBX21	5.59e-05	157	59	4	071f10d749b590b75a07ab3c7b00956dc7cda4da
ToppCell	facs-Lung-EPCAM-24m-Lymphocytic-NK_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CD82 BEND6 GZMA TBX21	5.59e-05	157	59	4	af110085dad5d26b0b7068a78f104ba784fa8564
ToppCell	facs-SCAT-Fat-24m-Lymphocytic-CD4-positive,_alpha-beta_T_cell\|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CD82 CLDND2 GZMA TBX21	5.59e-05	157	59	4	ad8c6eb34f5288288c4066119c17325afefbaafc
ToppCell	frontal_cortex-Non-neuronal-smooth_muscle_cell\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	CD82 CD9 NDUFA4L2 SLC2A4	5.73e-05	158	59	4	08806240228c5b780f5aef92ce2c278ae4d797cc
ToppCell	frontal_cortex-Non-neuronal-smooth_muscle_cell-SMC-SMC_Acta2\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	CD82 CD9 NDUFA4L2 SLC2A4	5.73e-05	158	59	4	496b6988f7b3439968351840ae22f56ffa1643f1
ToppCell	frontal_cortex-Non-neuronal-smooth_muscle_cell-SMC\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	CD82 CD9 NDUFA4L2 SLC2A4	5.73e-05	158	59	4	5b3d30f92b619f14a7b48502170000fa5783358a
ToppCell	facs-Marrow-Granulocytes-3m-Lymphocytic-NK_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BEND6 CLDND2 GZMA TBX21	5.88e-05	159	59	4	d2de9391b00b6c47f5fe28a1bad6da2097107ee0
ToppCell	facs-Marrow-Granulocytes-3m-Lymphocytic-NK_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BEND6 CLDND2 GZMA TBX21	5.88e-05	159	59	4	da6b7f8039adc19839d6c090a0b3d68fb6445a79
ToppCell	droplet-Lung-18m-Hematologic-lymphocytic-mature_NK_T_cell-mature_NK_T_cell_l44\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CD82 BEND6 GZMA TBX21	6.02e-05	160	59	4	6b0faaa371650563f585722f5b2fb319e124ec38
ToppCell	systemic_lupus_erythematosus-flare-Lymphocytic_T-CytoT_GZMK+-male\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	GZMA TBX21 LAMP3 NDUFA4L2	6.32e-05	162	59	4	19395bdb282b4a2d88cd33191af12c24a88c3d16
ToppCell	droplet-Spleen-nan-3m-Lymphocytic-NK_cell\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FKBP10 CD9 GZMA TBX21	6.47e-05	163	59	4	2e1c1193c04620cc187b1567dfba025beef1e4e1
ToppCell	facs-Spleen-nan-3m-Lymphocytic-NK_cell\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CD9 CLDND2 GZMA TBX21	6.63e-05	164	59	4	a187bd5beca017ef657ef07c006e7f94ea3b911b
ToppCell	droplet-Spleen-nan-24m-Lymphocytic-NK_cell\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CD9 CLDND2 GZMA TBX21	6.63e-05	164	59	4	7a51365bad2910c130bd952805f7a1bef51be481
ToppCell	367C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_0.5\|367C / Donor, Lineage, Cell class and subclass (all cells)	GZMA TBX21 PRPF38B TTC38	6.63e-05	164	59	4	4a834a7908d8aa643a2096c52430dad795898474
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Mesenchymal--glomerular_mesenchymal_cell-Renin-positive_Juxtaglomerular_Granular_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	FRZB NDUFA4L2 SLC35F1 SLC2A4	6.78e-05	165	59	4	9de841c1c95967c562720feba930246debc626fd
ToppCell	5'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_II_pneumocyte-AT2-AT2_L.0.1.2.4\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	GZMA TBX21 APLP1 TTC38	6.78e-05	165	59	4	4d364e1aae41aea483d1311e5e8ef4fc33e30d5e
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Mesenchymal-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	FRZB NDUFA4L2 SLC35F1 SLC2A4	6.78e-05	165	59	4	a612a7d3a5415ecacc3df8fbff0ce498f982aad0
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Mesenchymal--glomerular_mesenchymal_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	FRZB NDUFA4L2 SLC35F1 SLC2A4	6.78e-05	165	59	4	cdc94a640ec01c6892521bcd6f0ee0a66ff23866
ToppCell	wk_20-22-Hematologic-Myeloid-Mast\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	ADPRH CD82 SLC18A2 SVOPL	6.94e-05	166	59	4	004ab6a1425d812c7ce572205875fd702d4a9659
ToppCell	severe_influenza-gd_T\|World / disease group, cell group and cell class (v2)	GZMA TBX21 CD81 TTC38	7.44e-05	169	59	4	6d514dd2d1e5253bce49279f43aa2fa2b7c2653e
ToppCell	10x5'v1-week_12-13-Myeloid_neutrophil-granulo-eo/baso/mast-eosinophil\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	CD82 SLC18A2 SVOPL VAT1	7.44e-05	169	59	4	f68195510b91e287fe1507455ca067ece77a3897
ToppCell	severe-HSPC\|World / disease stage, cell group and cell class	SLC18A2 CACHD1 PCSK4 SVOPL	7.44e-05	169	59	4	b0421b73bfdc92f7a2762b4b670b9eae124aa702
ToppCell	390C-Lymphocytic-NK_cells-NK_cell_C\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	GZMA TBX21 TTC38 SLC27A3	7.61e-05	170	59	4	81341bf4fe090af70b2091b6b2579ed08d76e22d
ToppCell	wk_20-22-Hematologic-Myeloid-Eosinophil\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	CD82 BEND6 SLC18A2 SVOPL	7.79e-05	171	59	4	fa6e856e62b82ec4972e0098e73f237cc611891f
ToppCell	droplet-Lung-LUNG-1m-Lymphocytic-mature_NK_T_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CD82 GZMA TBX21 TTC38	7.79e-05	171	59	4	f12c2e48637b96557afbc2006a3a23ba21b7951e
ToppCell	droplet-Lung-LUNG-1m-Lymphocytic-Natural_Killer_T_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CD82 GZMA TBX21 TTC38	7.79e-05	171	59	4	12c98dea7370377695c5d22309f78ba03e282a0e
ToppCell	Bronchial_Biopsy-Immune-Mast_cells\|Bronchial_Biopsy / Tissue, Lineage and Cell class of Lung Cells from 10X	ADPRH SLC18A2 SVOPL VAT1	7.97e-05	172	59	4	c477008444d2d71071177807870d7455e90c2fad
ToppCell	droplet-Lung-21m-Hematologic-lymphocytic-mature_NK_T_cell-mature_NK_T_cell_l4\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CD82 CLDND2 APLP1 LHFPL1	8.15e-05	173	59	4	42272af45547422ef85e35f4a4c7d269e9ed7a8a
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Degenerative_Vascular_Smooth_Muscle_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SYNPO2 FRZB NDUFA4L2 CD81	8.15e-05	173	59	4	ecbf7167d4bec685e3460d826318544946f5f5c2
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Degenerative_Vascular_Smooth_Muscle_Cell-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SYNPO2 FRZB NDUFA4L2 CD81	8.15e-05	173	59	4	b8dc978c52de64afba21ff6cb32e79f07167448e
ToppCell	droplet-Lung-nan-18m-Lymphocytic-Natural_Killer_T_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CD82 GZMA TBX21 LHFPL1	8.33e-05	174	59	4	5b00a795a9dd1a77305fcac5017cb276afdc1a27
ToppCell	droplet-Lung-nan-18m-Lymphocytic-mature_NK_T_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CD82 GZMA TBX21 LHFPL1	8.33e-05	174	59	4	3340b44c77f55244e3c2e2ea479d42563f937040
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SYNPO2 FRZB NDUFA4L2 SLC35F1	8.90e-05	177	59	4	4943d040eee0f9dceaddc7498171281d170e271f
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SYNPO2 FRZB NDUFA4L2 SLC35F1	8.90e-05	177	59	4	3f2272b577c862dba8ccfb41184054bbd0ace6f5
ToppCell	3'-Airway_Nasal-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-Suprabasal_L.0.0.3.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SYNPO2 BEND6 CD9 LYPLAL1	8.90e-05	177	59	4	9e65b39fd797b6ce204b6480415810d1923acee5
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Degenerative_Vascular_Smooth_Muscle_Cell-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SYNPO2 FRZB CD81 SLC2A4	8.90e-05	177	59	4	88403b055eb9fdf96e4695fb6e0d78179e30a1e3
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Degenerative_Vascular_Smooth_Muscle_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SYNPO2 FRZB CD81 SLC2A4	8.90e-05	177	59	4	8903aeaab61abd81a148ea623038c5114b8a183b
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-Degenerative_Endothelial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SLC22A9 BTNL3 CD81 VAT1	9.10e-05	178	59	4	5636f2e89027955f406d420ff6df6a4b8c12cb20
ToppCell	10x5'-GI_large-bowel-Mast\|GI_large-bowel / Manually curated celltypes from each tissue	CD9 SLC18A2 CLDND2 VAT1	9.10e-05	178	59	4	d10ed2543c96e1a2373f847e0b82144771e26d07
ToppCell	10x5'-GI_large-bowel-Mast-Mast_cells\|GI_large-bowel / Manually curated celltypes from each tissue	CD9 SLC18A2 CLDND2 VAT1	9.10e-05	178	59	4	8fc5f735afa25ae43c2acb1c710ade6e9e093e3c
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Degenerative_Fibroblast-Degenerative_Fibroblast_119\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ADPRH SYNPO2 FRZB CD81	9.29e-05	179	59	4	68ccfe66474d049a926afc21bffa231446becc69
ToppCell	COPD-Stromal-SMC\|COPD / Disease state, Lineage and Cell class	SYNPO2 FRZB NDUFA4L2 SLC2A4	9.29e-05	179	59	4	5c705627bd13a5b2c7b0062fb3d94e4eb1589327
ToppCell	COPD-Stromal-SMC\|World / Disease state, Lineage and Cell class	SYNPO2 FRZB NDUFA4L2 SLC2A4	9.29e-05	179	59	4	b2709537ec1b46457ab85261f4cdd354e60a8b29
ToppCell	Control-Stromal-SMC\|Control / Disease state, Lineage and Cell class	SYNPO2 FRZB NDUFA4L2 SLC2A4	9.29e-05	179	59	4	1378051bc62009eec2dbecf3d5d89baedbeb84eb
ToppCell	droplet-Heart-nan-24m-Mesenchymal-smooth_muscle_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SYNPO2 NDUFA4L2 SVOPL SLC2A4	9.50e-05	180	59	4	78fdcfb3fdbf36469cae78407cda5bd0996930d8
ToppCell	367C-Myeloid-Mast_cell\|367C / Donor, Lineage, Cell class and subclass (all cells)	CD82 CD9 SLC18A2 SVOPL	9.70e-05	181	59	4	063fc83870f55f63c013f0276c1ec8f3abcbcf27
ToppCell	367C-Myeloid-Mast_cell-\|367C / Donor, Lineage, Cell class and subclass (all cells)	CD82 CD9 SLC18A2 SVOPL	9.70e-05	181	59	4	e1161c9828ee94518eb5bef0b6228d71299c2f59
ToppCell	3'-Broncho-tracheal-Mesenchymal-Mesenchymal_Myocytic-tracheobronchial_smooth_muscle_cell-SM_activated_stress_response-SM_activated_stress_response_L.2.3.0.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SYNPO2 FRZB NDUFA4L2 SLC2A4	9.91e-05	182	59	4	97bb07478f56a937b490fba121ee603db64134a1
ToppCell	3'-Broncho-tracheal-Mesenchymal-Mesenchymal_Myocytic-tracheobronchial_smooth_muscle_cell-SM_activated_stress_response\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SYNPO2 FRZB NDUFA4L2 SLC2A4	9.91e-05	182	59	4	1c1a687f728341c209b048b6715bcddd0ac20069
ToppCell	facs-Heart-LA-18m\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CD82 CD9 FRZB NDUFA4L2	9.91e-05	182	59	4	47b747722766dbcc6a73673e99ee5f938b82b890
ToppCell	severe_influenza-gd_T\|severe_influenza / disease group, cell group and cell class (v2)	GZMA TBX21 CD81 TTC38	9.91e-05	182	59	4	b6b44c90af3f0c0dddb2b171087865d8c15a3973
ToppCell	Pericytes-Myositis-ILD_01\|World / lung cells shred on cell class, cell subclass, sample id	SYNPO2 FRZB NDUFA4L2 SLC2A4	1.01e-04	183	59	4	4617b18da8d699a44e4c47980197b1e7eb951470
ToppCell	Somatosensory_Cortex_(S1)-Non-neuronal-Mesenchymal-Mes-Pericyte-Peri_L1-6_MUSTN1\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CD9 FRZB NDUFA4L2 SLC2A4	1.01e-04	183	59	4	944f7458b9127356815f75c88bbf7015ebdc8ec1
ToppCell	PND14-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP2-CAP2_prolif\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ATF7 LYPLAL1 CAMKMT TBC1D24	1.01e-04	183	59	4	3ef9ac1ae13b6172f9121ab1c129ecaa0fef460f
ToppCell	Somatosensory_Cortex_(S1)-Non-neuronal-Mesenchymal-Mes-Pericyte\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CD9 FRZB NDUFA4L2 SLC2A4	1.01e-04	183	59	4	cee6b821adff538078232689965d3e6c131e7d14
ToppCell	wk_15-18-Hematologic-Myeloid-MEP\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	PROKR1 CD82 SLC18A2 SVOPL	1.03e-04	184	59	4	19d61d0ab038b7e729e13a46f88b8cf31759485d
ToppCell	10x5'v1-week_14-16-Myeloid_neutrophil-granulo-eo/baso/mast-eosinophil\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	CD82 SLC18A2 SVOPL VAT1	1.03e-04	184	59	4	ce31684772e47a294155f368e50b49753f7c8e87
ToppCell	Control-Stromal-SMC\|World / Disease state, Lineage and Cell class	SYNPO2 FRZB NDUFA4L2 SLC2A4	1.03e-04	184	59	4	88b1a4c9a96a99fc3a39f7a2c3d0838739606f3e
ToppCell	droplet-Heart-nan-24m-Mesenchymal-smooth_muscle_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SYNPO2 NDUFA4L2 SVOPL SLC2A4	1.03e-04	184	59	4	f4344f3c407b2d4d703fe56e43d84dbfe60ba833
ToppCell	Smart-seq2-tissue-resident_(Smart-seq2)-myeloid-myeloid_granulocytic-mast_cell\|tissue-resident_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	CD82 CD9 SLC18A2 VAT1	1.06e-04	185	59	4	3fafb1d36c5f98a29d20a5ce5192c83d6f603514
ToppCell	Mid-temporal_gyrus_(MTG)-Non-neuronal-Mesenchymal-Mes-Pericyte\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CD9 FRZB NDUFA4L2 SLC2A4	1.06e-04	185	59	4	0e26a71fea526ebfe3b2d1c8d0d6d9b70282bbe9
ToppCell	5'-GW_trimst-1.5-LargeIntestine-Neuronal-neurons_B-Branch_B2_(eMN)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ZSCAN4 APLP1 NRSN1 VAT1	1.06e-04	185	59	4	3d6711030ca4328357b06d5497cf98cdefcd7f4f
ToppCell	Mid-temporal_gyrus_(MTG)-Non-neuronal-Mesenchymal-Mes-Pericyte-Peri_L1-6_MUSTN1\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CD9 FRZB NDUFA4L2 SLC2A4	1.06e-04	185	59	4	b3320b794b22e654a33f28b575c9f00023baf5f0
ToppCell	BAL-Control-Lymphocyte-T/NK-CD8+_T-CD8+_T_activated\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	SYNPO2 GZMA TBX21 LAMP3	1.06e-04	185	59	4	191d7e9b34bd1598cb4c18e0cb3d018bad83c757
ToppCell	(4)_Mast_cells\|World / Lung cell shreds - cell class (v4) and cell subclass (v4)	CD82 CD9 SLC18A2 SVOPL	1.06e-04	185	59	4	c91e1081e630a61c18f6af6d198bfcf296746852
ToppCell	BAL-Control-Lymphocyte-T/NK-CD8+_T-CD8+_T_activated-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	SYNPO2 GZMA TBX21 LAMP3	1.06e-04	185	59	4	99fe59c15c3c0f7afa7e182255e4bacfba346132
ToppCell	(4)_Mast_cells\|World / Lung cell shreds - cell class (v4) and cell subclass (v4)	CD82 CD9 SLC18A2 SVOPL	1.06e-04	185	59	4	3dd5d2237ab50b13a41c12f85e1b79cd72ea567b
ToppCell	Smart-seq2-tissue-resident_(Smart-seq2)-myeloid-myeloid_granulocytic\|tissue-resident_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	CD82 CD9 SLC18A2 VAT1	1.08e-04	186	59	4	de55471dd5c842026b409cfebf67fe32f079a011
ToppCell	nucseq-Mesenchymal-Myocytic-Myocytic_2-VSMC\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	SYNPO2 FRZB NDUFA4L2 SLC2A4	1.08e-04	186	59	4	c7885fd6dc7dc8fffc96f0112c51a365cf8a8f80
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_3\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SYNPO2 FRZB SLC35F1 SLC2A4	1.08e-04	186	59	4	4780af76237d7af2abbe2d8d5530cdf53e3ed0b7
Computational	Neighborhood of IL2RB	GZMA TBX21 TTC38	2.75e-04	46	30	3	GNF2_IL2RB
Computational	Neighborhood of PTPN4	GZMA TBX21 TTC38	3.52e-04	50	30	3	GNF2_PTPN4
Disease	X-23756 measurement	SLCO1B7 SLCO1A2	3.28e-05	5	54	2	EFO_0022126
Disease	hexadecenedioate (C16:1-DC) measurement	SLCO1B7 SLCO1A2	1.17e-04	9	54	2	EFO_0800562
Disease	glycochenodeoxycholate glucuronide (1) measurement	SLCO1B7 SLCO1A2	2.53e-04	13	54	2	EFO_0800474
Disease	Developmental Academic Disorder	CAMKMT SLC17A6	1.29e-03	29	54	2	C1330966
Disease	Learning Disorders	CAMKMT SLC17A6	1.29e-03	29	54	2	C0023186
Disease	Learning Disturbance	CAMKMT SLC17A6	1.29e-03	29	54	2	C0751263
Disease	Adult Learning Disorders	CAMKMT SLC17A6	1.29e-03	29	54	2	C0751262
Disease	Learning Disabilities	CAMKMT SLC17A6	1.29e-03	29	54	2	C0751265
Disease	fatty liver disease (biomarker_via_orthology)	SLCO1A2 FIS1	1.67e-03	33	54	2	DOID:9452 (biomarker_via_orthology)
Disease	lysophosphatidylethanolamine measurement	SLCO1B7 SLCO1A2	2.58e-03	41	54	2	EFO_0010225
Disease	low density lipoprotein cholesterol measurement, cholesteryl esters:total lipids ratio	ACAT2 SLCO1A2 NPC1L1	2.79e-03	153	54	3	EFO_0004611, EFO_0020944
Disease	cholestasis (biomarker_via_orthology)	SLCO1B7 SLCO1A2	3.66e-03	49	54	2	DOID:13580 (biomarker_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
GLLCGALCGVVMGMI	BTNL3	241	Q6UXE8
DMVLGMCFSGLGIPV	B3GLCT	421	Q6Y288
MQSVDSMLGTVGGCG	LINC00696	1	Q6ZRV3
IGMNMVCAGSLRGGR	GZMA	191	P12544
LIMGAGGGSLIVLSM	APLP1	586	P51693
VGPVAGGIMGCIMVL	CACHD1	1096	Q5VU97
GGIMGCIMVLVLAVY	CACHD1	1101	Q5VU97
ALGLILAGMGAAIGM	ERVV-2	321	B6SEH9
INGGCGMVVGTASTM	ATF7	271	P17544
IAVGAVMMFVGFLGC	CD81	66	P60033
LVGMAEALLKGGGTM	BEND6	111	Q5SZJ8
GVGAVTMLMGFLGCI	CD82	61	P27701
TMLMGFLGCIGAVNE	CD82	66	P27701
GLAGMCGCAILMTVA	SLC2A4	356	P14672
AGMAIAMALTGGIGF	IMPDH2	76	P12268
RVCDMGLLMGAAILG	KDM8	121	Q8N371
ALGLILAGMGAAIGM	ERVV-1	321	B6SEH8
MAIVGGMALGVAGLA	FIS1	126	Q9Y3D6
AVTLGGPVLCGMSMD	PCSK4	716	Q6UW60
GGTSMAGCLLMSVFV	NRSN1	126	Q8IZ57
VIGAIVVGLCLMGMG	LAMP3	386	Q9UQV4
MGRCMGAAQFVGGLL	LHFPL1	116	Q86WI0
GCAVQMFLGLAMGTT	OR13C2	96	Q8NGS9
IPMIGLICLGMGSAA	NDUFA4L2	21	Q9NRX3
GGVAVVLGAVMAAMG	NPC1L1	671	Q9UHC9
AGALMMLVGFLGCCG	CD9	66	P21926
GRLITGMDRGLMGMC	FKBP10	96	Q96AY3
NRILIGGFSMGGCMA	LYPLAL1	116	Q5VWZ2
AGGLTLIGGVMMCIA	CLDN18	181	P56856
LIGGVMMCIACRGLA	CLDN18	186	P56856
SGTIMMSGCGILTNG	NEURL4	401	Q96JN8
GCAVQMFLGLAMGTT	OR13C9	96	Q8NGT0
IMVGLMHIGFGIVLC	MS4A12	96	Q9NXJ0
MAPGMSGRGGAALLC	TMEM132E	1	Q6IEE7
AMGITLGMCPSGIAF	SLC22A9	231	Q8IVM8
LGMCPSGIAFMTLAG	SLC22A9	236	Q8IVM8
PIMIGIGCVVMGLGC	SLCO1A2	86	P46721
GIGCFLMGTGSILMA	SLCO1B7	51	G3V0H7
GMGTSGSLCRIGAMV	SVOPL	431	Q8N434
EGGCGAAMRAMCIGL	ADPRH	126	P54922
GVGVVGMVMGLRIRC	CLDND2	71	Q8NHS1
CELGGGMTCLAGLMV	CAMKMT	151	Q7Z624
GMALVGIMLVCGIGN	PROKR1	66	Q8TCW9
SMFMAGGSDCLIVGG	TBC1D24	496	Q9ULP9
VCILGMGCMVGADVL	SLC35F1	191	Q5T1Q4
MGISNGVGTLSGMVC	SLC17A6	446	Q9P2U8
MGTGDFICISMTGGA	SYNPO2	1	Q9UMS6
ALCIGGGMGIAMCVQ	ACAT2	381	Q9BWD1
HMSGSLLGIVGCMGI	SLC27A3	331	Q5K4L6
MVCGSPGGMLLLRAG	FRZB	1	Q92765
KAGGGCVMTIGEMLR	PRPF38B	191	Q5VTL8
LVLGAIAEGCMQGMV	TNPO2	416	O14787
FRGICMMIGVNPGGV	TNPO2	821	O14787
CLLMMFLISPGAAGG	SLC12A9	466	Q9BXP2
SLGGVGMMCSLSEQG	RIMKLB	231	Q9ULI2
ITFQGVPMVMGAGCI	ZSCAN4	261	Q8NAM6
GLAGECDAMVGMMGV	ZNF697	226	Q5TEC3
CDAMVGMMGVGVAGG	ZNF697	231	Q5TEC3
TALGIMCGAIGYMGT	TM9SF3	561	Q9HD45
MGHAMATGLVLIGTG	TTC38	66	Q5R3I4
MAAGGVGMAAVQLCR	VAT1	196	Q99536
LMVGVVMFTLGFAGC	TSPAN14	66	Q8NG11
MGIALGGLAMGVLVG	SLC18A2	221	Q05940
MLLGMEAAGSAGGVV	PC	686	P11498
MGIVEPGCGDMLTGT	TBX21	1	Q9UL17