Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionolfactory receptor activity

OR8K1 OR5T1 OR7E24 OR2AT4 OR7C1 OR5B12 OR5B2 OR5D18 OR6C4 OR10Q1 OR5B17 OR2G2 OR1D5 OR14J1 OR5T2 OR6C65 OR6T1 OR1D4 OR1D2

1.73e-144318519GO:0004984
GeneOntologyMolecularFunctionG protein-coupled receptor activity

OR8K1 HCAR3 VN1R5 OR5T1 HCAR2 GPR15 OR7E24 OR2AT4 FZD3 SIGMAR1 OR7C1 OR5B12 OR5B2 OR5D18 OR6C4 OR10Q1 OR5B17 OR2G2 OR1D5 OR14J1 OR5T2 OR6C65 OR6T1 OR1D4 OR1D2

1.77e-148848525GO:0004930
GeneOntologyMolecularFunctiontransmembrane signaling receptor activity

OR8K1 HCAR3 VN1R5 OR5T1 HCAR2 GPR15 OR7E24 OR2AT4 FZD3 SIGMAR1 OR7C1 OR5B12 OR5B2 OR5D18 OR6C4 OR10Q1 OR5B17 OR2G2 OR1D5 OR14J1 OR5T2 OR6C65 OR6T1 OR1D4 OR1D2

2.00e-1013538525GO:0004888
GeneOntologyMolecularFunctiontransporter activity

RHCG GPR89B CACNA1S CLPTM1L SLC8A1 HCN4 ABCA13 SLC38A9 SLC22A14 HCN3 KCNJ14 ABCB8 ATG2B SIDT1 TMC8 GPR89A SLC15A5 SLC6A15 ATG2A ASIC4 SLC4A3 SLC9A6 SLC44A3 SLC4A2

4.38e-1012898524GO:0005215
GeneOntologyMolecularFunctionodorant binding

OR8K1 OR5T1 OR5B12 OR5B2 OR5D18 OR10Q1 OR5B17 OR14J1 OR5T2

3.50e-09127859GO:0005549
GeneOntologyMolecularFunctiontransmembrane transporter activity

RHCG GPR89B CACNA1S SLC8A1 HCN4 ABCA13 SLC38A9 SLC22A14 HCN3 KCNJ14 ABCB8 SIDT1 TMC8 GPR89A SLC15A5 SLC6A15 ASIC4 SLC4A3 SLC9A6 SLC44A3 SLC4A2

1.53e-0811808521GO:0022857
GeneOntologyMolecularFunctionnicotinic acid receptor activity

HCAR3 HCAR2

1.79e-052852GO:0070553
GeneOntologyMolecularFunctionmonoatomic ion transmembrane transporter activity

GPR89B CACNA1S SLC8A1 HCN4 HCN3 KCNJ14 TMC8 GPR89A SLC6A15 ASIC4 SLC4A3 SLC9A6 SLC4A2

2.91e-057938513GO:0015075
GeneOntologyMolecularFunctiongated channel activity

GPR89B CACNA1S HCN4 HCN3 KCNJ14 TMC8 GPR89A ASIC4

8.86e-05334858GO:0022836
GeneOntologyMolecularFunctionsodium ion transmembrane transporter activity

SLC8A1 HCN4 HCN3 SLC6A15 ASIC4 SLC9A6

9.03e-05171856GO:0015081
GeneOntologyMolecularFunctionvoltage-gated monoatomic ion channel activity

GPR89B CACNA1S HCN4 HCN3 KCNJ14 GPR89A

1.27e-04182856GO:0005244
GeneOntologyMolecularFunctionvoltage-gated channel activity

GPR89B CACNA1S HCN4 HCN3 KCNJ14 GPR89A

1.35e-04184856GO:0022832
GeneOntologyMolecularFunctioninorganic molecular entity transmembrane transporter activity

RHCG CACNA1S SLC8A1 HCN4 HCN3 KCNJ14 SLC6A15 ASIC4 SLC4A3 SLC9A6 SLC4A2

3.62e-047588511GO:0015318
GeneOntologyMolecularFunctionchannel activity

RHCG GPR89B CACNA1S HCN4 HCN3 KCNJ14 TMC8 GPR89A ASIC4

3.92e-04525859GO:0015267
GeneOntologyMolecularFunctionpassive transmembrane transporter activity

RHCG GPR89B CACNA1S HCN4 HCN3 KCNJ14 TMC8 GPR89A ASIC4

3.97e-04526859GO:0022803
GeneOntologyMolecularFunctionmonoatomic ion channel activity

GPR89B CACNA1S HCN4 HCN3 KCNJ14 TMC8 GPR89A ASIC4

7.51e-04459858GO:0005216
GeneOntologyMolecularFunctionbranched-chain amino acid transmembrane transporter activity

SLC38A9 SLC6A15

7.88e-0410852GO:0015658
GeneOntologyMolecularFunctionintracellularly cAMP-activated cation channel activity

HCN4 HCN3

7.88e-0410852GO:0005222
GeneOntologyMolecularFunctionmetal ion transmembrane transporter activity

CACNA1S SLC8A1 HCN4 HCN3 KCNJ14 SLC6A15 ASIC4 SLC9A6

8.17e-04465858GO:0046873
GeneOntologyMolecularFunctionactive transmembrane transporter activity

SLC8A1 ABCA13 ABCB8 SLC15A5 SLC6A15 SLC4A3 SLC9A6 SLC4A2

9.63e-04477858GO:0022804
GeneOntologyMolecularFunctionchloride:bicarbonate antiporter activity

SLC4A3 SLC4A2

1.35e-0313852GO:0140900
GeneOntologyMolecularFunctionbicarbonate:monoatomic anion antiporter activity

SLC4A3 SLC4A2

1.35e-0313852GO:0140829
GeneOntologyMolecularFunctionintracellularly cyclic nucleotide-activated monoatomic cation channel activity

HCN4 HCN3

1.35e-0313852GO:0005221
GeneOntologyMolecularFunctioncyclic nucleotide-activated monoatomic ion channel activity

HCN4 HCN3

1.35e-0313852GO:0043855
GeneOntologyMolecularFunctioninorganic cation transmembrane transporter activity

RHCG CACNA1S SLC8A1 HCN4 HCN3 KCNJ14 SLC6A15 ASIC4 SLC9A6

1.38e-03627859GO:0022890
GeneOntologyMolecularFunctionsodium channel activity

HCN4 HCN3 ASIC4

1.42e-0352853GO:0005272
GeneOntologyMolecularFunctionsecondary active transmembrane transporter activity

SLC8A1 SLC15A5 SLC6A15 SLC4A3 SLC9A6 SLC4A2

1.66e-03296856GO:0015291
GeneOntologyMolecularFunctionvoltage-gated monoatomic anion channel activity

GPR89B GPR89A

2.34e-0317852GO:0008308
GeneOntologyMolecularFunctionantiporter activity

SLC8A1 SLC4A3 SLC9A6 SLC4A2

2.87e-03138854GO:0015297
GeneOntologyMolecularFunctionligand-gated monoatomic cation channel activity

HCN4 HCN3 KCNJ14 ASIC4

3.02e-03140854GO:0099094
GeneOntologyMolecularFunctionnucleotide receptor activity

HCAR3 HCAR2

3.91e-0322852GO:0016502
GeneOntologyMolecularFunctionpurinergic nucleotide receptor activity

HCAR3 HCAR2

3.91e-0322852GO:0001614
GeneOntologyMolecularFunctionmonoatomic anion transmembrane transporter activity

GPR89B GPR89A SLC4A3 SLC4A2

3.96e-03151854GO:0008509
GeneOntologyMolecularFunctionvoltage-gated monoatomic cation channel activity

CACNA1S HCN4 HCN3 KCNJ14

4.05e-03152854GO:0022843
GeneOntologyMolecularFunctionankyrin binding

RHCG SLC8A1

4.28e-0323852GO:0030506
GeneOntologyMolecularFunctionarachidonate epoxygenase activity

CYP2J2 CYP2S1

4.65e-0324852GO:0008392
GeneOntologyMolecularFunctioncAMP binding

HCN4 HCN3

5.04e-0325852GO:0030552
GeneOntologyMolecularFunctionvoltage-gated sodium channel activity

HCN4 HCN3

5.45e-0326852GO:0005248
GeneOntologyMolecularFunctionpotassium ion transmembrane transporter activity

HCN4 HCN3 KCNJ14 SLC9A6

5.65e-03167854GO:0015079
GeneOntologyMolecularFunctionarachidonate monooxygenase activity

CYP2J2 CYP2S1

5.87e-0327852GO:0008391
GeneOntologyMolecularFunctionmonoatomic cation transmembrane transporter activity

CACNA1S SLC8A1 HCN4 HCN3 KCNJ14 SLC6A15 ASIC4 SLC9A6

7.28e-03664858GO:0008324
GeneOntologyMolecularFunctionbicarbonate transmembrane transporter activity

SLC4A3 SLC4A2

8.18e-0332852GO:0015106
GeneOntologyMolecularFunctionsolute:inorganic anion antiporter activity

SLC4A3 SLC4A2

8.18e-0332852GO:0005452
GeneOntologyMolecularFunctionorganic anion transmembrane transporter activity

SLC38A9 SLC22A14 SLC6A15 SLC4A3 SLC4A2

8.30e-03293855GO:0008514
GeneOntologyMolecularFunctionintracellularly ligand-gated monoatomic ion channel activity

HCN4 HCN3

8.68e-0333852GO:0005217
GeneOntologyMolecularFunctionactive monoatomic ion transmembrane transporter activity

SLC8A1 SLC6A15 SLC4A3 SLC9A6 SLC4A2

9.26e-03301855GO:0022853
GeneOntologyMolecularFunctionligand-gated monoatomic ion channel activity

HCN4 HCN3 KCNJ14 ASIC4

9.32e-03193854GO:0015276
GeneOntologyMolecularFunctionvoltage-gated potassium channel activity

HCN4 HCN3 KCNJ14

9.44e-03102853GO:0005249
GeneOntologyMolecularFunctionaromatase activity

CYP2J2 CYP2S1

9.73e-0335852GO:0070330
GeneOntologyMolecularFunctionlipid transporter activity

CLPTM1L ABCA13 ATG2B ATG2A

9.83e-03196854GO:0005319
GeneOntologyMolecularFunctionligand-gated channel activity

HCN4 HCN3 KCNJ14 ASIC4

1.00e-02197854GO:0022834
GeneOntologyBiologicalProcessdetection of chemical stimulus involved in sensory perception of smell

OR8K1 OR5T1 OR7E24 OR2AT4 OR7C1 OR5B12 OR5B2 OR5D18 OR6C4 OR10Q1 OR5B17 OR2G2 OR1D5 OR14J1 OR5T2 OR6C65 OR6T1 OR1D4 OR1D2

8.05e-154328419GO:0050911
GeneOntologyBiologicalProcesssensory perception of smell

OR8K1 OR5T1 OR7E24 OR2AT4 OR7C1 OR5B12 OR5B2 OR5D18 OR6C4 OR10Q1 OR5B17 OR2G2 OR1D5 OR14J1 OR5T2 OR6C65 OR6T1 OR1D4 OR1D2

3.03e-144658419GO:0007608
GeneOntologyBiologicalProcesssensory perception of chemical stimulus

OR8K1 VN1R5 OR5T1 OR7E24 OR2AT4 OR7C1 OR5B12 OR5B2 OR5D18 OR6C4 OR10Q1 OR5B17 OR2G2 OR1D5 OR14J1 OR5T2 OR6C65 OR6T1 OR1D4 OR1D2

4.66e-145478420GO:0007606
GeneOntologyBiologicalProcessdetection of chemical stimulus involved in sensory perception

OR8K1 OR5T1 OR7E24 OR2AT4 OR7C1 OR5B12 OR5B2 OR5D18 OR6C4 OR10Q1 OR5B17 OR2G2 OR1D5 OR14J1 OR5T2 OR6C65 OR6T1 OR1D4 OR1D2

6.45e-144858419GO:0050907
GeneOntologyBiologicalProcessdetection of stimulus involved in sensory perception

OR8K1 OR5T1 OR7E24 OR2AT4 OR7C1 OR5B12 OR5B2 OR5D18 OR6C4 OR10Q1 OR5B17 OR2G2 OR1D5 OR14J1 OR5T2 TAC1 OR6C65 OR6T1 OR1D4 OR1D2

1.48e-135828420GO:0050906
GeneOntologyBiologicalProcessdetection of chemical stimulus

OR8K1 OR5T1 OR7E24 OR2AT4 OR7C1 OR5B12 OR5B2 OR5D18 OR6C4 OR10Q1 OR5B17 OR2G2 OR1D5 OR14J1 OR5T2 OR6C65 OR6T1 OR1D4 OR1D2

2.56e-135248419GO:0009593
GeneOntologyBiologicalProcessdetection of stimulus

OR8K1 OR5T1 OR7E24 OR2AT4 OR7C1 OR5B12 OR5B2 OR5D18 OR6C4 OR10Q1 OR5B17 OR2G2 OR1D5 OR14J1 OR5T2 TAC1 OR6C65 OR6T1 OR1D4 OR1D2

7.70e-127228420GO:0051606
GeneOntologyBiologicalProcessG protein-coupled receptor signaling pathway

OR8K1 HCAR3 VN1R5 OR5T1 HCAR2 GPR15 OR7E24 OR2AT4 FZD3 SIGMAR1 OR7C1 OR5B12 OR5B2 OR5D18 OR6C4 OR10Q1 OR5B17 OR2G2 OR1D5 OR14J1 OR5T2 TAC1 OR6C65 OR6T1 OR1D4 OR1D2

2.34e-1113958426GO:0007186
GeneOntologyBiologicalProcesssensory perception

OR8K1 VN1R5 OR5T1 OR7E24 OR2AT4 OR7C1 WFS1 OR5B12 OR5B2 OR5D18 OR6C4 OR10Q1 OR5B17 OR2G2 OR1D5 POMGNT1 OR14J1 OR5T2 TAC1 OR6C65 OR6T1 OR1D4 OR1D2

2.78e-1110728423GO:0007600
GeneOntologyBiologicalProcessregulation of pH

RHCG GPR89B GPR89A SLC4A3 SLC9A6 SLC4A2

9.60e-06120846GO:0006885
GeneOntologyBiologicalProcessregulation of intracellular pH

GPR89B GPR89A SLC4A3 SLC9A6 SLC4A2

4.10e-0594845GO:0051453
GeneOntologyBiologicalProcessregulation of cellular pH

GPR89B GPR89A SLC4A3 SLC9A6 SLC4A2

5.79e-05101845GO:0030641
GeneOntologyBiologicalProcesspositive regulation of adiponectin secretion

HCAR3 HCAR2

9.78e-054842GO:0070165
GeneOntologyBiologicalProcessmonoatomic ion transmembrane transport

GPR89B CACNA1S SLC8A1 HCN4 HCN3 KCNJ14 ABCB8 TMC8 GPR89A SLC6A15 ASIC4 SLC4A3 SLC9A6 SLC4A2

1.53e-0411158414GO:0034220
GeneOntologyBiologicalProcesssodium ion import across plasma membrane

SLC8A1 HCN4 SLC9A6

1.78e-0427843GO:0098719
GeneOntologyBiologicalProcesssodium ion transmembrane transport

SLC8A1 HCN4 HCN3 SLC6A15 ASIC4 SLC9A6

2.07e-04208846GO:0035725
GeneOntologyBiologicalProcessintracellular monoatomic ion homeostasis

RHCG GPR89B CACNA1S SLC8A1 WFS1 TMC8 GPR89A SLC4A3 SLC9A6 SLC4A2

2.15e-046228410GO:0006873
GeneOntologyBiologicalProcessendocrine hormone secretion

HCAR3 HCAR2 CYP2J2 TAC1

2.76e-0477844GO:0060986
GeneOntologyBiologicalProcessinorganic ion import across plasma membrane

CACNA1S SLC8A1 HCN4 KCNJ14 SLC9A6

2.88e-04142845GO:0099587
GeneOntologyBiologicalProcessinorganic cation import across plasma membrane

CACNA1S SLC8A1 HCN4 KCNJ14 SLC9A6

2.88e-04142845GO:0098659
GeneOntologyBiologicalProcessnegative regulation of lipid catabolic process

HCAR3 HCAR2 BSCL2

3.56e-0434843GO:0050995
GeneOntologyBiologicalProcessmonoatomic ion transport

GPR89B CACNA1S SLC8A1 HCN4 WFS1 HCN3 KCNJ14 ABCB8 TMC8 GPR89A SLC6A15 ASIC4 SLC4A3 SLC9A6 SLC4A2

3.97e-0413748415GO:0006811
GeneOntologyBiologicalProcessadiponectin secretion

HCAR3 HCAR2

4.52e-048842GO:0070162
GeneOntologyBiologicalProcessregulation of adiponectin secretion

HCAR3 HCAR2

4.52e-048842GO:0070163
GeneOntologyBiologicalProcessmonoatomic cation homeostasis

RHCG GPR89B CACNA1S SLC8A1 WFS1 TMC8 GPR89A SLC4A3 SLC9A6 SLC4A2

5.77e-047058410GO:0055080
GeneOntologyBiologicalProcessmonoatomic ion homeostasis

RHCG GPR89B CACNA1S SLC8A1 WFS1 TMC8 GPR89A SLC4A3 SLC9A6 SLC4A2

6.57e-047178410GO:0050801
GeneOntologyBiologicalProcessinorganic ion transmembrane transport

RHCG CACNA1S SLC8A1 HCN4 HCN3 KCNJ14 ABCB8 SLC6A15 ASIC4 SLC4A3 SLC9A6 SLC4A2

8.24e-0410178412GO:0098660
GeneOntologyBiologicalProcessintracellular monoatomic cation homeostasis

GPR89B CACNA1S SLC8A1 WFS1 TMC8 GPR89A SLC4A3 SLC9A6 SLC4A2

8.45e-04611849GO:0030003
GeneOntologyBiologicalProcesscellular response to caffeine

CACNA1S SLC8A1

8.80e-0411842GO:0071313
GeneOntologyBiologicalProcesssodium ion transport

SLC8A1 HCN4 HCN3 SLC6A15 ASIC4 SLC9A6

9.06e-04275846GO:0006814
GeneOntologyBiologicalProcesslong-term memory

PTCHD1 RASGRF1 TAC1

9.87e-0448843GO:0007616
GeneOntologyBiologicalProcessglycophagy

ATG2B ATG2A

1.05e-0312842GO:0061723
GeneOntologyCellularComponentendoplasmic reticulum membrane

OR8K1 CLPTM1L RASGRF2 CYP2J2 SIGMAR1 OR7C1 WFS1 OR5D18 PGAP2 CERS3 ATG2B TMC8 ZDHHC14 BSCL2 CYP2S1 ATG2A SLC9A6

1.74e-0512938617GO:0005789
GeneOntologyCellularComponentendoplasmic reticulum subcompartment

OR8K1 CLPTM1L RASGRF2 CYP2J2 SIGMAR1 OR7C1 WFS1 OR5D18 PGAP2 CERS3 ATG2B TMC8 ZDHHC14 BSCL2 CYP2S1 ATG2A SLC9A6

1.85e-0512998617GO:0098827
GeneOntologyCellularComponentnuclear outer membrane-endoplasmic reticulum membrane network

OR8K1 CLPTM1L RASGRF2 CYP2J2 SIGMAR1 OR7C1 WFS1 OR5D18 PGAP2 CERS3 ATG2B TMC8 ZDHHC14 BSCL2 CYP2S1 ATG2A SLC9A6

2.43e-0513278617GO:0042175
GeneOntologyCellularComponentphagophore

ATG2B ATG2A

5.01e-053862GO:0061908
GeneOntologyCellularComponentHCN channel complex

HCN4 HCN3

9.98e-054862GO:0098855
GeneOntologyCellularComponentGolgi cisterna

GPR89B LLGL1 ZDHHC14 GPR89A CHSY1

2.39e-04135865GO:0031985
GeneOntologyCellularComponentGolgi cisterna membrane

GPR89B ZDHHC14 GPR89A CHSY1

6.14e-0494864GO:0032580
GeneOntologyCellularComponentGolgi stack

GPR89B LLGL1 ZDHHC14 GPR89A CHSY1

7.05e-04171865GO:0005795
GeneOntologyCellularComponentpotassium channel complex

HCN4 HCN3 KCNJ14 ABCB8

8.98e-04104864GO:0034705
GeneOntologyCellularComponentmonoatomic ion channel complex

GPR89B CACNA1S HCN4 HCN3 KCNJ14 ABCB8 GPR89A

9.44e-04378867GO:0034702
GeneOntologyCellularComponentlipid droplet

SIGMAR1 ATG2B BSCL2 ATG2A

1.35e-03116864GO:0005811
GeneOntologyCellularComponentbasolateral plasma membrane

RHCG SLC8A1 LLGL1 RASGRF1 HCN4 SLC4A2

2.07e-03320866GO:0016323
GeneOntologyCellularComponentdendrite

CACNA1S SLC8A1 IFT52 RASGRF1 HCN4 FZD3 WFS1 HCN3 KCNJ14 SLC9A6

2.72e-038588610GO:0030425
GeneOntologyCellularComponentdendritic tree

CACNA1S SLC8A1 IFT52 RASGRF1 HCN4 FZD3 WFS1 HCN3 KCNJ14 SLC9A6

2.76e-038608610GO:0097447
GeneOntologyCellularComponentcation channel complex

CACNA1S HCN4 HCN3 KCNJ14 ABCB8

2.86e-03235865GO:0034703
DomainOlfact_rcpt

OR8K1 OR5T1 OR7E24 OR2AT4 OR7C1 OR5B12 OR5B2 OR5D18 OR6C4 OR10Q1 OR5B17 OR2G2 OR1D5 OR14J1 OR5T2 OR6C65 OR6T1 OR1D4 OR1D2

8.45e-153938419IPR000725
DomainG_PROTEIN_RECEP_F1_1

OR8K1 HCAR3 VN1R5 OR5T1 HCAR2 GPR15 OR7E24 OR2AT4 OR7C1 OR5B12 OR5B2 OR5D18 OR6C4 OR10Q1 OR5B17 OR2G2 OR1D5 OR14J1 OR5T2 OR6C65 OR6T1 OR1D4 OR1D2

2.04e-146858423PS00237
DomainG_PROTEIN_RECEP_F1_2

OR8K1 HCAR3 VN1R5 OR5T1 HCAR2 GPR15 OR7E24 OR2AT4 OR7C1 OR5B12 OR5B2 OR5D18 OR6C4 OR10Q1 OR5B17 OR2G2 OR1D5 OR14J1 OR5T2 OR6C65 OR6T1 OR1D4 OR1D2

2.46e-146918423PS50262
DomainGPCR_Rhodpsn

OR8K1 HCAR3 VN1R5 OR5T1 HCAR2 GPR15 OR7E24 OR2AT4 OR7C1 OR5B12 OR5B2 OR5D18 OR6C4 OR10Q1 OR5B17 OR2G2 OR1D5 OR14J1 OR5T2 OR6C65 OR6T1 OR1D4 OR1D2

2.54e-146928423IPR000276
Domain7tm_1

OR8K1 HCAR3 OR5T1 HCAR2 GPR15 OR7E24 OR2AT4 OR7C1 OR5B12 OR5B2 OR5D18 OR6C4 OR10Q1 OR5B17 OR2G2 OR1D5 OR14J1 OR5T2 OR6C65 OR6T1 OR1D4 OR1D2

1.63e-136778422PF00001
DomainGPCR_Rhodpsn_7TM

OR8K1 HCAR3 OR5T1 HCAR2 GPR15 OR7E24 OR2AT4 OR7C1 OR5B12 OR5B2 OR5D18 OR6C4 OR10Q1 OR5B17 OR2G2 OR1D5 OR14J1 OR5T2 OR6C65 OR6T1 OR1D2

1.29e-126708421IPR017452
DomainHCAR2/3_rcpt

HCAR3 HCAR2

2.00e-052842IPR028017
DomainATG2

ATG2B ATG2A

2.00e-052842IPR026849
DomainATG2_CAD

ATG2B ATG2A

2.00e-052842PF13329
DomainATG2_CAD_motif

ATG2B ATG2A

2.00e-052842IPR026885
DomainSerum_albumin/AFP/Afamin

AFM AFP

5.98e-053842IPR021177
DomainAnion_exchange_CS

SLC4A3 SLC4A2

5.98e-053842IPR018241
DomainALBUMIN

AFM AFP

1.19e-044842SM00103
DomainSerum_albumin_N

AFM AFP

1.19e-044842IPR014760
DomainSerum_albumin_CS

AFM AFP

1.19e-044842IPR020857
DomainSerum_albumin

AFM AFP

1.19e-044842PF00273
DomainALBUMIN_2

AFM AFP

1.19e-044842PS51438
DomainIon_trans_N

HCN4 HCN3

1.19e-044842PF08412
DomainALBUMIN_1

AFM AFP

1.19e-044842PS00212
DomainIon_trans_N

HCN4 HCN3

1.19e-044842IPR013621
DomainATG_C

ATG2B ATG2A

1.98e-045842PF09333
DomainSerum_albumin-like

AFM AFP

1.98e-045842IPR020858
DomainAnion_exchange

SLC4A3 SLC4A2

1.98e-045842IPR001717
DomainAutophagy-rel_C

ATG2B ATG2A

1.98e-045842IPR015412
DomainALB/AFP/VDB

AFM AFP

2.96e-046842IPR000264
DomainANION_EXCHANGER_2

SLC4A3 SLC4A2

4.14e-047842PS00220
DomainANION_EXCHANGER_1

SLC4A3 SLC4A2

4.14e-047842PS00219
DomainVPS13_N

ATG2B ATG2A

5.50e-048842IPR026854
DomainChorein_N

ATG2B ATG2A

5.50e-048842PF12624
DomainBand3_cytoplasmic_dom

SLC4A3 SLC4A2

7.05e-049842IPR013769
DomainBand_3_cyto

SLC4A3 SLC4A2

7.05e-049842PF07565
Domain-

SLC4A3 SLC4A2

7.05e-0498423.40.1100.10
DomainPTrfase/Anion_transptr

SLC4A3 SLC4A2

8.79e-0410842IPR016152
DomainHCO3_cotransp

SLC4A3 SLC4A2

8.79e-0410842PF00955
DomainHCO3_transpt_euk

SLC4A3 SLC4A2

8.79e-0410842IPR003020
DomainHCO3_transpt_C

SLC4A3 SLC4A2

8.79e-0410842IPR011531
DomainK_chnl_volt-dep_EAG/ELK/ERG

HCN4 HCN3

1.76e-0314842IPR003938
DomainRas_G-nucl-exch_fac_CS

RASGRF1 RASGRF2

1.76e-0314842IPR019804
DomainRasGEFN

RASGRF1 RASGRF2

3.60e-0320842SM00229
DomainRasGEF_N

RASGRF1 RASGRF2

3.97e-0321842PF00618
DomainRASGEF_NTER

RASGRF1 RASGRF2

4.36e-0322842PS50212
DomainRas-like_Gua-exchang_fac_N

RASGRF1 RASGRF2

4.36e-0322842IPR000651
DomainRASGEF

RASGRF1 RASGRF2

6.06e-0326842PS00720
DomainRASGEF_CAT

RASGRF1 RASGRF2

7.50e-0329842PS50009
DomainRasGEF

RASGRF1 RASGRF2

8.01e-0330842PF00617
Domain-

RASGRF1 RASGRF2

8.01e-03308421.10.840.10
DomainRas_GEF_dom

RASGRF1 RASGRF2

8.01e-0330842IPR023578
DomainRASGEF_cat_dom

RASGRF1 RASGRF2

8.01e-0330842IPR001895
DomainRasGEF

RASGRF1 RASGRF2

8.01e-0330842SM00147
DomainCNMP_BINDING_1

HCN4 HCN3

9.08e-0332842PS00888
DomainCNMP_BINDING_2

HCN4 HCN3

9.08e-0332842PS00889
PathwayREACTOME_OLFACTORY_SIGNALING_PATHWAY

OR8K1 OR5T1 OR7E24 OR2AT4 OR7C1 OR5B12 OR5B2 OR5D18 OR6C4 OR10Q1 OR5B17 OR2G2 OR1D5 OR14J1 OR5T2 OR6C65 OR6T1 OR1D4 OR1D2

1.25e-134177119M4072
PathwayKEGG_OLFACTORY_TRANSDUCTION

OR8K1 OR5T1 OR7E24 OR2AT4 OR7C1 OR5B12 OR5D18 OR6C4 OR10Q1 OR5B17 OR2G2 OR1D5 OR14J1 OR5T2 OR6C65 OR6T1 OR1D4 OR1D2

4.75e-133897118M14091
PathwayREACTOME_SENSORY_PERCEPTION

OR8K1 OR5T1 OR7E24 OR2AT4 OR7C1 OR5B12 OR5B2 OR5D18 OR6C4 OR10Q1 OR5B17 OR2G2 OR1D5 OR14J1 OR5T2 OR6C65 OR6T1 OR1D4 OR1D2

1.99e-106367119M41834
PathwayWP_GPCRS_ODORANT

GPR89B VN1R5 OR5T1 OR7E24 GPR89A OR5T2

1.37e-04157716MM15872
PathwayREACTOME_SLC_MEDIATED_TRANSMEMBRANE_TRANSPORT

RHCG SLC8A1 SLC6A15 SLC4A3 SLC9A6 SLC44A3 SLC4A2

1.90e-04238717MM15076
PathwayREACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES

SLC8A1 SLC6A15 SLC4A3 SLC9A6 SLC4A2

2.09e-04108715M823
PathwayREACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES

SLC8A1 SLC6A15 SLC4A3 SLC9A6 SLC4A2

2.19e-04109715MM15074
PathwayREACTOME_SLC_MEDIATED_TRANSMEMBRANE_TRANSPORT

RHCG SLC8A1 SLC6A15 SLC4A3 SLC9A6 SLC44A3 SLC4A2

2.50e-04249717M5988
PathwayWP_GPCRS_CLASS_A_RHODOPSINLIKE

HCAR3 GPR15 OR7C1 OR1D5 OR14J1 OR1D4 OR1D2

3.26e-04260717M39397
PathwayREACTOME_OLFACTORY_SIGNALING_PATHWAY

OR2AT4 OR1D5 OR14J1 OR1D2

4.22e-0470714MM14984
PathwayREACTOME_BICARBONATE_TRANSPORTERS

SLC4A3 SLC4A2

1.10e-0310712M27335
PathwayREACTOME_BICARBONATE_TRANSPORTERS

SLC4A3 SLC4A2

1.10e-0310712MM15073
PathwayWP_GPCRS_OTHER

VN1R5 OR7E24 OR1D5 OR1D2

1.38e-0396714MM15939
Pubmed

The human olfactory receptor gene family.

OR8K1 OR5T1 OR7E24 OR2AT4 OR7C1 OR5B12 OR5B2 OR5D18 OR6C4 OR10Q1 OR5B17 OR2G2 OR1D5 OR14J1 OR5T2 OR6T1 OR1D4 OR1D2

1.23e-15541861814983052
Pubmed

Different evolutionary processes shaped the mouse and human olfactory receptor gene families.

OR8K1 OR5T1 OR7E24 OR2AT4 OR7C1 OR5B12 OR5B2 OR5D18 OR10Q1 OR1D5 OR14J1 OR5T2 OR6C65 OR1D2

1.34e-13340861411875048
Pubmed

The olfactory receptor gene superfamily of the mouse.

OR8K1 OR5T1 OR7E24 OR2AT4 OR7C1 OR5B12 OR5B2 OR5D18 OR10Q1 OR1D5 OR14J1 OR5T2 OR6C65 OR1D2

1.34e-13340861411802173
Pubmed

A unified nomenclature for vertebrate olfactory receptors.

OR8K1 OR5T1 OR7E24 OR2AT4 OR7C1 OR5B12 OR5B2 OR5D18 OR10Q1 OR1D5 OR14J1 OR5T2 OR6C65 OR1D2

1.51e-13343861432295537
Pubmed

Odorant receptor expressed sequence tags demonstrate olfactory expression of over 400 genes, extensive alternate splicing and unequal expression levels.

OR8K1 OR5T1 OR7E24 OR2AT4 OR7C1 OR5B12 OR5B2 OR5D18 OR10Q1 OR1D5 OR14J1 OR5T2 OR6C65 OR1D2

1.70e-13346861414611657
Pubmed

DEFOG: a practical scheme for deciphering families of genes.

OR8K1 OR7E24 OR7C1 OR5B12 OR5B2 OR5D18 OR1D5 OR1D4 OR1D2

3.99e-0921986912213199
Pubmed

RASGRF2 controls nuclear migration in postnatal retinal cone photoreceptors.

RASGRF1 RASGRF2

6.04e-06286226743081
Pubmed

Niacin Ameliorates Hepatic Steatosis by Inhibiting De Novo Lipogenesis Via a GPR109A-Mediated PKC-ERK1/2-AMPK Signaling Pathway in C57BL/6 Mice Fed a High-Fat Diet.

HCAR3 HCAR2

6.04e-06286231858105
Pubmed

Deficiency of metabolite sensing receptor HCA2 impairs the salutary effect of niacin in hemorrhagic shock.

HCAR3 HCAR2

6.04e-06286230625381
Pubmed

Exploring the role of the metabolite-sensing receptor GPR109a in diabetic nephropathy.

HCAR3 HCAR2

6.04e-06286232068460
Pubmed

The activation of retinal HCA2 receptors by systemic beta-hydroxybutyrate inhibits diabetic retinal damage through reduction of endoplasmic reticulum stress and the NLRP3 inflammasome.

HCAR3 HCAR2

6.04e-06286230657794
Pubmed

Activated niacin receptor HCA2 inhibits chemoattractant-mediated macrophage migration via Gβγ/PKC/ERK1/2 pathway and heterologous receptor desensitization.

HCAR3 HCAR2

6.04e-06286228186140
Pubmed

Ketones and pain: unexplored role of hydroxyl carboxylic acid receptor type 2 in the pathophysiology of neuropathic pain.

HCAR3 HCAR2

6.04e-06286230085883
Pubmed

Nicotinic acid receptor abnormalities in human skin cancer: implications for a role in epidermal differentiation.

HCAR3 HCAR2

6.04e-06286221655214
Pubmed

Atg2A/B deficiency switches cytoprotective autophagy to non-canonical caspase-8 activation and apoptosis.

ATG2B ATG2A

6.04e-06286228800131
Pubmed

Melatonin alleviates titanium nanoparticles induced osteolysis via activation of butyrate/GPR109A signaling pathway.

HCAR3 HCAR2

6.04e-06286234092246
Pubmed

The Immunometabolomic Interface Receptor Hydroxycarboxylic Acid Receptor 2 Mediates the Therapeutic Effects of Dimethyl Fumarate in Autoantibody-Induced Skin Inflammation.

HCAR3 HCAR2

6.04e-06286230154797
Pubmed

(D)-beta-Hydroxybutyrate inhibits adipocyte lipolysis via the nicotinic acid receptor PUMA-G.

HCAR3 HCAR2

6.04e-06286215929991
Pubmed

The niacin/butyrate receptor GPR109A suppresses mammary tumorigenesis by inhibiting cell survival.

HCAR3 HCAR2

6.04e-06286224371223
Pubmed

Novel G protein-coupled receptors: a gene family of putative human olfactory receptor sequences.

OR1D5 OR1D2

6.04e-0628621315913
Pubmed

High dietary niacin may increase prostaglandin formation but does not increase tumor formation in ApcMin/+ mice.

HCAR3 HCAR2

6.04e-06286221774590
Pubmed

Activation of HCA2 regulates microglial responses to alleviate neurodegeneration in LPS-induced in vivo and in vitro models.

HCAR3 HCAR2

6.04e-06286236991440
Pubmed

The cardiac sodium-calcium exchanger NCX1 is a key player in the initiation and maintenance of a stable heart rhythm.

SLC8A1 HCN4

6.04e-06286223761399
Pubmed

Inflammation stimulates niacin receptor (GPR109A/HCA2) expression in adipose tissue and macrophages.

HCAR3 HCAR2

6.04e-06286225320346
Pubmed

The Inhibition of RasGRF2, But Not RasGRF1, Alters Cocaine Reward in Mice.

RASGRF1 RASGRF2

6.04e-06286231182637
Pubmed

Molecular identification of high and low affinity receptors for nicotinic acid.

HCAR3 HCAR2

6.04e-06286212522134
Pubmed

The role of HCA2 (GPR109A) in regulating macrophage function.

HCAR3 HCAR2

6.04e-06286223882124
Pubmed

Crosstalk between microbiome, regulatory T cells and HCA2 orchestrates the inflammatory response in a murine psoriasis model.

HCAR3 HCAR2

6.04e-06286236891315
Pubmed

Nicotinic acid inhibits glucose-stimulated insulin secretion via the G protein-coupled receptor PUMA-G in murine islet β cells.

HCAR3 HCAR2

6.04e-06286221441844
Pubmed

GPR109a Regulates Phenotypic and Functional Alterations in Macrophages and the Progression of Type 1 Diabetes.

HCAR3 HCAR2

6.04e-06286236208084
Pubmed

Transgenerational rescue of a genetic defect in long-term potentiation and memory formation by juvenile enrichment.

RASGRF1 RASGRF2

6.04e-06286219193896
Pubmed

G Protein-Coupled Receptor 109A and Host Microbiota Modulate Intestinal Epithelial Integrity During Sepsis.

HCAR3 HCAR2

6.04e-06286230271409
Pubmed

Parabacteroides distasonis ameliorates insulin resistance via activation of intestinal GPR109a.

HCAR3 HCAR2

6.04e-06286238007572
Pubmed

The role of the C-terminus of the human hydroxycarboxylic acid receptors 2 and 3 in G protein activation using Gα-engineered yeast cells.

HCAR3 HCAR2

6.04e-06286226656756
Pubmed

Human intestinal anion exchanger isoforms: expression, distribution, and membrane localization.

SLC4A3 SLC4A2

6.04e-06286211248201
Pubmed

Mammalian Atg2 proteins are essential for autophagosome formation and important for regulation of size and distribution of lipid droplets.

ATG2B ATG2A

6.04e-06286222219374
Pubmed

Niacin fine-tunes energy homeostasis through canonical GPR109A signaling.

HCAR3 HCAR2

6.04e-06286230596513
Pubmed

The niacin receptor HCAR2 modulates microglial response and limits disease progression in a mouse model of Alzheimer's disease.

HCAR3 HCAR2

6.04e-06286235320002
Pubmed

Biased allosteric activation of ketone body receptor HCAR2 suppresses inflammation.

HCAR3 HCAR2

6.04e-06286237597514
Pubmed

GPR109A (PUMA-G/HM74A) mediates nicotinic acid-induced flushing.

HCAR3 HCAR2

6.04e-06286216322797
Pubmed

The Role of GPR109a Signaling in Niacin Induced Effects on Fed and Fasted Hepatic Metabolism.

HCAR3 HCAR2

6.04e-06286233924461
Pubmed

Hydroxycarboxylic acid receptor 2 mediates dimethyl fumarate's protective effect in EAE.

HCAR3 HCAR2

6.04e-06286224691444
Pubmed

BHBA treatment improves cognitive function by targeting pleiotropic mechanisms in transgenic mouse model of Alzheimer's disease.

HCAR3 HCAR2

6.04e-06286231914599
Pubmed

Ketone Body 3-Hydroxybutyrate Ameliorates Atherosclerosis via Receptor Gpr109a-Mediated Calcium Influx.

HCAR3 HCAR2

6.04e-06286233977048
Pubmed

Butyrate ameliorates caerulein-induced acute pancreatitis and associated intestinal injury by tissue-specific mechanisms.

HCAR3 HCAR2

6.04e-06286231347703
Pubmed

Nicotinic acid receptor agonists.

HCAR3 HCAR2

6.04e-06286218983141
Pubmed

Gut microbial metabolite butyrate protects against proteinuric kidney disease through epigenetic- and GPR109a-mediated mechanisms.

HCAR3 HCAR2

6.04e-06286231366236
Pubmed

PUMA-G, an IFN-gamma-inducible gene in macrophages is a novel member of the seven transmembrane spanning receptor superfamily.

HCAR3 HCAR2

6.04e-06286211745392
Pubmed

Activation of H-Ras in the endoplasmic reticulum by the RasGRF family guanine nucleotide exchange factors.

RASGRF1 RASGRF2

6.04e-06286214749369
Pubmed

Distinct roles for Ras-guanine nucleotide-releasing factor 1 (Ras-GRF1) and Ras-GRF2 in the induction of long-term potentiation and long-term depression.

RASGRF1 RASGRF2

6.04e-06286216467520
Pubmed

Loss of GPR109A/HCAR2 induces aging-associated hepatic steatosis.

HCAR3 HCAR2

6.04e-06286230659164
Pubmed

Niacin-induced hyperglycemia is partially mediated via niacin receptor GPR109a in pancreatic islets.

HCAR3 HCAR2

6.04e-06286225622782
Pubmed

Modulation of HDL metabolism by the niacin receptor GPR109A in mouse hepatocytes.

HCAR3 HCAR2

6.04e-06286220655299
Pubmed

Evidence for constitutive dimerization of niacin receptor subtypes.

HCAR3 HCAR2

6.04e-06286220380810
Pubmed

GPR109A mediates the effects of hippuric acid on regulating osteoclastogenesis and bone resorption in mice.

HCAR3 HCAR2

6.04e-06286233420329
Pubmed

Expression and localization of GPR109A (PUMA-G/HM74A) mRNA and protein in mammalian retinal pigment epithelium.

HCAR3 HCAR2

6.04e-06286219223991
Pubmed

GPR109A Expression in the Murine Min6 Pancreatic Beta Cell Line, and Its Relation with Glucose Metabolism and Inflammation.

HCAR3 HCAR2

6.04e-06286226116596
Pubmed

GPHR is a novel anion channel critical for acidification and functions of the Golgi apparatus.

GPR89B GPR89A

6.04e-06286218794847
Pubmed

Expression and activation of the ketone body receptor HCAR2/GPR109A promotes preservation of retinal endothelial cell barrier function.

HCAR3 HCAR2

6.04e-06286235649469
Pubmed

Molecular identification of nicotinic acid receptor.

HCAR3 HCAR2

6.04e-06286212646212
Pubmed

GPR109A expressed on medullary thymic epithelial cells affects thymic Treg development.

HCAR3 HCAR2

6.04e-06286237595951
Pubmed

PUMA-G and HM74 are receptors for nicotinic acid and mediate its anti-lipolytic effect.

HCAR3 HCAR2

6.04e-06286212563315
Pubmed

The hypophagic response to heat stress is not mediated by GPR109A or peripheral β-OH butyrate.

HCAR3 HCAR2

6.04e-06286226936786
Pubmed

Hydroxycarboxylic Acid Receptor 2, a Pleiotropically Linked Receptor for the Multiple Sclerosis Drug, Monomethyl Fumarate. Possible Implications for the Inflammatory Response.

HCAR3 HCAR2

6.04e-06286234084164
Pubmed

Niacin increases adiponectin and decreases adipose tissue inflammation in high fat diet-fed mice.

HCAR3 HCAR2

6.04e-06286223967184
Pubmed

GPR109A gene deletion ameliorates gonadectomy-induced bone loss in mice.

HCAR3 HCAR2

6.04e-06286235489706
Pubmed

A murine CDC25/ras-GRF-related protein implicated in Ras regulation.

RASGRF1 RASGRF2

6.04e-0628628293576
Pubmed

Involvement of the Niacin Receptor GPR109a in the LocalControl of Glucose Uptake in Small Intestine of Type 2Diabetic Mice.

HCAR3 HCAR2

6.04e-06286226371038
Pubmed

Ras-GRF2 regulates nestin-positive stem cell density and onset of differentiation during adult neurogenesis in the mouse dentate gyrus.

RASGRF1 RASGRF2

6.04e-06286228966131
Pubmed

Alloreactive T cells deficient of the short-chain fatty acid receptor GPR109A induce less graft-versus-host disease.

HCAR3 HCAR2

6.04e-06286234653248
Pubmed

Phenolic acids suppress adipocyte lipolysis via activation of the nicotinic acid receptor GPR109A (HM74a/PUMA-G).

HCAR3 HCAR2

6.04e-06286219136666
Pubmed

GPHR-dependent functions of the Golgi apparatus are essential for the formation of lamellar granules and the skin barrier.

GPR89B GPR89A

6.04e-06286222572823
Pubmed

G Protein-Coupled Receptor 109A Maintains the Intestinal Integrity and Protects Against ETEC Mucosal Infection by Promoting IgA Secretion.

HCAR3 HCAR2

6.04e-06286233488584
Pubmed

The environment versus genetics in controlling the contribution of MAP kinases to synaptic plasticity.

RASGRF1 RASGRF2

6.04e-06286217141611
Pubmed

Lactate-induced activation of HCA2 improves survival in mice with sepsis.

HCAR3 HCAR2

6.04e-06286230951370
Pubmed

cDNA cloning and tissue distribution of mRNAs for two proteins that are related to the band 3 Cl-/HCO3- exchanger.

SLC4A3 SLC4A2

6.04e-0628622294114
Pubmed

Deorphanization of GPR109B as a receptor for the beta-oxidation intermediate 3-OH-octanoic acid and its role in the regulation of lipolysis.

HCAR3 HCAR2

6.04e-06286219561068
Pubmed

Sequence, structure, and evolution of a complete human olfactory receptor gene cluster.

OR1D5 OR1D4 OR1D2

7.99e-061686310673334
Pubmed

Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV.

SIGMAR1 WFS1 PGAP2 ABCB8 DPY19L4 ARFGEF1 GPR89A POMGNT1 SLC6A15 BSCL2 CYP2S1 SLC4A2

1.17e-051061861233845483
Pubmed

The β-hydroxybutyrate receptor HCA2 activates a neuroprotective subset of macrophages.

HCAR3 HCAR2

1.81e-05386224845831
Pubmed

A conserved ATG2-GABARAP family interaction is critical for phagophore formation.

ATG2B ATG2A

1.81e-05386232009292
Pubmed

Alpha-fetoprotein, the major fetal serum protein, is not essential for embryonic development but is required for female fertility.

AFM AFP

1.81e-05386212297623
Pubmed

Hyperhomocysteinemia is detrimental to pregnancy in mice and is associated with preterm birth.

HCAR3 HCAR2

1.81e-05386223579073
Pubmed

Short-chain fatty acids directly exert anti-inflammatory responses in podocytes and tubular epithelial cells exposed to high glucose.

HCAR3 HCAR2

1.81e-05386237215085
Pubmed

Oral Dimethyl Fumarate Targets HCA2-Expressing Skin Cells in the Imiquimod Mouse Model.

HCAR3 HCAR2

1.81e-05386235189149
Pubmed

RasGRF suppresses Cdc42-mediated tumour cell movement, cytoskeletal dynamics and transformation.

RASGRF1 RASGRF2

1.81e-05386221685891
Pubmed

Colonic gene expression in conventional and germ-free mice with a focus on the butyrate receptor GPR109A and the butyrate transporter SLC5A8.

HCAR3 HCAR2

1.81e-05386220033346
Pubmed

The Butyrate-Producing Bacterium Clostridium butyricum Suppresses Clostridioides difficile Infection via Neutrophil- and Antimicrobial Cytokine-Dependent but GPR43/109a-Independent Mechanisms.

HCAR3 HCAR2

1.81e-05386233597149
Pubmed

Genetic and structural studies of RABL3 reveal an essential role in lymphoid development and function.

GPR89B GPR89A

1.81e-05386232220963
Pubmed

Nicotinic acid-induced flushing is mediated by activation of epidermal langerhans cells.

HCAR3 HCAR2

1.81e-05386217008386
Pubmed

Effects of high fat diet on GPR109A and GPR81 gene expression.

HCAR3 HCAR2

1.81e-05386222842580
Pubmed

Niacin lipid efficacy is independent of both the niacin receptor GPR109A and free fatty acid suppression.

HCAR3 HCAR2

1.81e-05386222914621
Pubmed

Niacin protects against abdominal aortic aneurysm formation via GPR109A independent mechanisms: role of NAD+/nicotinamide.

HCAR3 HCAR2

1.81e-05386231710686
Pubmed

Niacin stimulates adiponectin secretion through the GPR109A receptor.

HCAR3 HCAR2

1.81e-05386219141678
Pubmed

Deficiency of Prebiotic Fiber and Insufficient Signaling Through Gut Metabolite-Sensing Receptors Leads to Cardiovascular Disease.

HCAR3 HCAR2

1.81e-05386232093510
Pubmed

Expression and function of bicarbonate/chloride exchangers in the preimplantation mouse embryo.

SLC4A3 SLC4A2

1.81e-0538627592657
Pubmed

International Union of Basic and Clinical Pharmacology. LXXXII: Nomenclature and Classification of Hydroxy-carboxylic Acid Receptors (GPR81, GPR109A, and GPR109B).

HCAR3 HCAR2

1.81e-05386221454438
Pubmed

Genetic polymorphisms of CYP2S1, CYP2J2 and CYP2R1 genes in three Chinese populations: Han, Tibetan and Uighur.

CYP2J2 CYP2S1

1.81e-05386230019995
Pubmed

Rare and potentially pathogenic variants in hydroxycarboxylic acid receptor genes identified in breast cancer cases.

HCAR3 HCAR2

1.81e-05386234852802
Pubmed

Nicotinic acid- and monomethyl fumarate-induced flushing involves GPR109A expressed by keratinocytes and COX-2-dependent prostanoid formation in mice.

HCAR3 HCAR2

1.81e-05386220664170
InteractionGPR182 interactions

CLPTM1L GTF2H4 SIGMAR1 WFS1 ABCB8 ARFGEF1 GPR89A POMGNT1 CYP2S1 SLC4A2 FANCA

6.03e-074557211int:GPR182
InteractionSTARD3NL interactions

CDC123 WFS1 POMGNT1 CYP2S1 SLC4A2

1.15e-0652725int:STARD3NL
InteractionP2RY8 interactions

SIGMAR1 WFS1 ABCB8 ARFGEF1 CYP2S1 SLC4A2 FANCA

3.51e-06179727int:P2RY8
InteractionGPR17 interactions

SIGMAR1 WFS1 SLC38A9 ABCB8 ARFGEF1 GPR89A SLC4A2 FANCA

7.53e-06283728int:GPR17
InteractionADGRG5 interactions

FZD3 SIGMAR1 ABCB8 DPY19L4 SLC4A2

2.06e-0593725int:ADGRG5
InteractionGABRE interactions

GPR89B ABCB8 BSCL2 SLC4A2

3.05e-0550724int:GABRE
InteractionTLCD1 interactions

CDC123 SLC6A15 BSCL2

6.41e-0522723int:TLCD1
InteractionVIPR2 interactions

WFS1 ABCB8 GPR89A POMGNT1 CYP2S1 SLC4A2

6.79e-05194726int:VIPR2
InteractionVIPR1 interactions

CLPTM1L SIGMAR1 ABCB8 GPR89A CYP2S1 SLC4A2

9.20e-05205726int:VIPR1
CytobandEnsembl 112 genes in cytogenetic band chr11q12

OR8K1 OR5T1 OR5B12 OR5B2 OR5D18 OR10Q1 OR5B17 OR5T2 BSCL2

1.91e-08345869chr11q12
Cytoband11q12.1

OR8K1 OR5T1 OR5B12 OR5B2 OR10Q1 OR5B17 OR5T2

2.44e-0816186711q12.1
Cytoband17p13.3

OR1D5 OR1D4 OR1D2

6.21e-048886317p13.3
CytobandEnsembl 112 genes in cytogenetic band chr2q35

SMARCAL1 ASIC4 SLC4A3

1.87e-03129863chr2q35
Cytoband15q26.3

CERS3 CHSY1

2.71e-034186215q26.3
Cytoband4q13.3

AFM AFP

2.84e-03428624q13.3
CytobandEnsembl 112 genes in cytogenetic band chr7q36

ABCB8 DYNC2I1 SLC4A2

3.38e-03159863chr7q36
Cytoband12q13.2

OR6C4 OR6C65

4.83e-035586212q13.2
Cytoband1p34.1

POMGNT1 HPDL

5.18e-03578621p34.1
Cytoband1q22

GLMP HCN3

5.18e-03578621q22
Cytoband1q21.1

GPR89B GPR89A

6.10e-03628621q21.1
Cytoband11q13.1

SPDYC ATG2A

6.29e-036386211q13.1
GeneFamilySolute carriers

RHCG SLC8A1 SLC38A9 SLC22A14 SLC15A5 SLC6A15 SLC4A3 SLC9A6 SLC44A3 SLC4A2

1.36e-063956510752
GeneFamilyOlfactory receptors, family 5

OR5T1 OR5B12 OR5B2 OR5D18 OR5B17 OR5T2

3.03e-06112656152
GeneFamilyHydroxy-carboxylic acid receptors

HCAR3 HCAR2

3.81e-053652200
GeneFamilyOlfactory receptors, family 1

OR1D5 OR1D4 OR1D2

3.98e-0440653147
GeneFamilyCyclic nucleotide gated channels

HCN4 HCN3

5.62e-0410652250
GeneFamilyOlfactory receptors, family 6

OR6C4 OR6C65 OR6T1

8.17e-0451653153
GeneFamilyAutophagy related

ATG2B ATG2A

6.25e-03336521022
GeneFamilyCytochrome P450 family 2

CYP2J2 CYP2S1

7.02e-03356521001
ToppCell367C-Myeloid-Dendritic-pDC|Dendritic / Donor, Lineage, Cell class and subclass (all cells)

MAL CYP2J2 INPP4A SIDT1 ZDHHC14

1.87e-05170855fbb7019c6fba87326702b51f6819ea1af5f3a9b7
ToppCellCF-Lymphoid-pDC|CF / Disease state, Lineage and Cell class

FZD3 STAG3L1 INPP4A SIDT1 SLC4A3

2.20e-05176855dd1e529a9e413bcaab43584afbe059e1464ffb53
ToppCelldroplet-Kidney-nan-21m-Epithelial-Epcam____kidney_collecting_duct_principal_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RHCG SLC8A1 MAL CYP2S1 SLC44A3

2.59e-05182855fe4fb213dc0ca482b0f94097fe1b0a51fc2690e2
ToppCelldroplet-Kidney-KIDNEY-1m-Epithelial-Epcam_____kidney_distal_convoluted_tubule_epithelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RHCG SLC8A1 MAL ABCA13 AFM

2.66e-05183855f3728b1a51951c7349f77a3e4d2671ca3a8d2a44
ToppCelldroplet-Kidney-KIDNEY-1m-Epithelial-kidney_distal_convoluted_tubule_epithelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RHCG SLC8A1 MAL ABCA13 AFM

2.73e-051848558939b6d795992775df0ff58ed1ec9d421a00bcc4
ToppCellfacs-Kidney-nan-24m-Epithelial-kidney_collecting_duct_principal_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RHCG SLC8A1 MAL ABCA13 CERS3

2.87e-051868557380af16e537cc49a2bb24ac50663d13c38459a7
ToppCellfacs-Kidney-nan-24m-Epithelial-kidney_collecting_duct_principal_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RHCG SLC8A1 MAL ABCA13 CERS3

2.87e-05186855d56ccbe26bfddba0e2c54e7c7a5ca7f46fd3d891
ToppCellSmart-seq2-lymph_node_(Smart-seq2)-lymphocytic-T_lymphocytic-effector_CD4-positive,_alpha-beta_T_cell|lymph_node_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

MAL RASGRF2 INPP4A TMC8 TENT5C

2.95e-05187855e61c1755531469dd3850c9740474b5ad4e0499c1
ToppCelldroplet-Kidney-nan-3m-Epithelial-kidney_distal_convoluted_tubule_epithelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RHCG SLC8A1 MAL ABCA13 AFM

3.10e-05189855e127e3be626bc513e151d41812f0b7adb89d5da6
ToppCelldroplet-Kidney-nan-3m-Epithelial-Epcam_____kidney_distal_convoluted_tubule_epithelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RHCG SLC8A1 MAL ABCA13 AFM

3.10e-05189855ff637ae0afdb1fdc67451be7e1e4fe575fbcfff4
ToppCellsevere-Lymphocytic-Plasmablast|severe / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

CLPTM1L WFS1 TENT5C CD180 HPDL

3.26e-0519185573660d762c9d451980c21adc426db6670bcaf37f
ToppCelldroplet-Kidney-nan-18m-Epithelial-Epcam_____kidney_distal_convoluted_tubule_epithelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RHCG SLC8A1 MAL ABCA13 AFM

3.34e-051928556fb56d062c35617b18b927704bf5fba894faed81
ToppCelldroplet-Kidney-nan-3m-Epithelial-Epcam____kidney_collecting_duct_principal_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RHCG SLC8A1 MAL SLC4A3 SLC44A3

3.42e-05193855536b277d90070c4571c592a3c6323b4bf4819f67
ToppCelldroplet-Kidney-nan-3m-Epithelial-kidney_collecting_duct_principal_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RHCG SLC8A1 MAL SLC4A3 SLC44A3

3.42e-051938550499611c21d283321ef6dd24add154dea48da1b7
ToppCelldistal-Hematologic-B_cell-2|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

GPR15 SIDT1 TENT5C CD180 STAG3

3.42e-05193855202dc5ec2437602c15658074728c5f5aeeab0466
ToppCelldroplet-Kidney-nan-18m-Epithelial-kidney_distal_convoluted_tubule_epithelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RHCG SLC8A1 MAL ABCA13 AFM

3.42e-05193855fa8bcf2a5ab7b08fae98a1466a936995142b4309
ToppCellnormal_Lymph_Node-Myeloid_cells-CD1c+_DCs|normal_Lymph_Node / Location, Cell class and cell subclass

HCAR3 HCAR2 SLC8A1 CYP2S1 SLC4A3

3.60e-05195855cd4d61a463e0e87b711e08ceedee5bef5d735e64
ToppCelldistal-2-Hematologic-B_cell|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

GPR15 SIDT1 TENT5C CD180 STAG3

3.69e-051968552587b5d83fb4f1c4a69894aa0f5f7cb3898faa09
ToppCellTransverse-(5)_Dendritic_cell-(50)_cDC2|Transverse / shred on region, Cell_type, and subtype

HCAR3 HCAR2 SLC8A1 CYP2S1 SLC4A3

4.06e-05200855eea523f7512b54d7443651bce3ff6d043a9897aa
ToppCellTransverse-Dendritic_cell-cDC2|Transverse / Region, Cell class and subclass

HCAR3 HCAR2 SLC8A1 CYP2S1 SLC4A3

4.06e-0520085580730a6372627543b84d8fb1b94c481db17c6500
Drugcurarine

HCAR3 HCAR2 TAC1 FANCA

2.54e-0626854CID000198004
DiseaseMood Disorders

HCN4 SIGMAR1 WFS1 TAC1 BSCL2

9.04e-05168795C0525045
Diseaseinsulin-like growth factor-binding protein 7 measurement

AFM AFP

1.05e-046792EFO_0008161
Diseaseafamin measurement

AFM AFP

2.52e-049792EFO_0008015
DiseaseShort Rib-Polydactyly Syndrome

IFT52 DYNC2I1

5.42e-0413792C0036996
DiseaseSaldino-Noonan Syndrome

IFT52 DYNC2I1

6.31e-0414792C0036069
DiseaseMajewski Syndrome

IFT52 DYNC2I1

6.31e-0414792C0024507
Diseaseanemia (implicated_via_orthology)

SLC4A3 SLC4A2

7.27e-0415792DOID:2355 (implicated_via_orthology)
DiseaseAmnesia

SIGMAR1 TAC1

9.38e-0417792C0002622
DiseaseTactile Amnesia

SIGMAR1 TAC1

9.38e-0417792C0750906
DiseaseAmnestic State

SIGMAR1 TAC1

9.38e-0417792C0750907
DiseaseDissociative Amnesia

SIGMAR1 TAC1

9.38e-0417792C0236795
DiseaseGlobal Amnesia

SIGMAR1 TAC1

9.38e-0417792C0262497
DiseaseHysterical amnesia

SIGMAR1 TAC1

9.38e-0417792C0233750
DiseaseTemporary Amnesia

SIGMAR1 TAC1

9.38e-0417792C0233796
Diseaseobsessive-compulsive disorder

HCAR3 HCAR2 SLC6A15

2.48e-03100793EFO_0004242

Protein segments in the cluster

PeptideGeneStartEntry
RFTQEIFAFLISLIF

SLC4A2

821

P04920
PFTQEIFAFLISLIF

SLC4A3

821

P48751
EQLARTELFIFFTSL

CYP2J2

451

P51589
FFLFFLTESLTLPTQ

AFM

11

P43652
FELSLSIFLTLLSNF

ARFGEF1

501

Q9Y6D6
FIINLAASDFIFLVT

GPR15

71

P49685
NFLLSFVEFFEKLLL

ABCA13

731

Q86UQ4
LPNTTEFLEFSFNFL

CD180

51

Q99467
QDALFFLKDFFTSLV

ATG2A

1591

Q2TAZ0
LFFLKDFFTSLSAEV

ATG2B

1716

Q96BY7
IFLSSIAFFQDSLIN

INPP4A

96

Q96PE3
FFLATFNEISTLLIV

OR5D18

201

Q8NGL1
LVTLDFTSRIIDFFT

LLGL1

331

Q15334
LRNFSFLEISFTTVF

OR6C65

61

A6NJZ3
LFIINFISFFSALAV

PGAP2

186

Q9UHJ9
TFNEAELFVASILFL

OR2G2

196

Q8NGZ5
SSRIFLFNLAVADFL

HCAR2

61

Q8TDS4
LIDLDFSFTFSLLDL

DYNC2I1

496

Q8WVS4
FLFFTTILQAFSLES

CYP2S1

451

Q96SQ9
ILQVFFFIALASSEV

OR14J1

96

Q9UGF5
SSFNIFFVLLVIFIS

OR5B2

201

Q96R09
ENFLVLDVFFEALTS

ASIC4

411

Q96FT7
FFVAFITAESFLLAS

OR5B12

101

Q96R08
SVSSLFLFSVFLFVA

PCDHB15

696

Q9Y5E8
VLSDTFFLLDLVLNF

HCN3

131

Q9P1Z3
LRNFSFLEISFTSIF

OR6C4

61

Q8NGE1
IVFNVVSDTFFLIDL

HCN4

296

Q9Y3Q4
FTKSLFTEDTFFLEL

HPDL

326

Q96IR7
FTLFLFSVLFAISEV

INSL5

6

Q9Y5Q6
VASFLAAFLFALETQ

KCNJ14

131

Q9UNX9
LISFTEEFDVQVFLF

OR5T1

26

Q8NG75
EFLLLGFSATSEIQF

OR7C1

11

O76099
NTLFFIFSTIFFISR

CERS3

261

Q8IU89
DFTTLFDLSIFQLDT

IFT52

286

Q9Y366
TLSDIFLLFKSSDFI

CDC123

126

O75794
FDVIFLVSALSSILF

GPR89A

426

B7ZAQ6
FDVIFLVSALSSILF

GPR89B

426

P0CG08
FTNFILLFILLSSAA

CACNA1S

801

Q13698
VFLFTFLSELVPFES

FANCA

471

O15360
FFFLSNDELLEILSE

DNAH7

1071

Q8WXX0
FLQAISLFLLDTFSV

DPY19L4

271

Q7Z388
FSVFTTLPDLLFIFE

MAL

16

P21145
IQFSSALVFTRLLEF

GLMP

116

Q8WWB7
ATLFTFLTFLIDVTR

FZD3

216

Q9NPG1
SFLSVFETVLDALFL

SLC44A3

581

Q8N4M1
TLVFSSLLLFGFAEQ

BSCL2

161

Q96G97
LREFSLAATVTVFFL

SLC22A14

486

Q9Y267
EDTTFFLTLLPLFIF

SLC15A5

301

A6NIM6
NLESFFFFLASLTLL

SLC15A5

506

A6NIM6
SDTLSFIARIFLLFQ

SLC38A9

436

Q8NBW4
SIFLIFLLNFTESRT

AFP

6

P02771
ISLADLATIFFAQFV

AFP

41

P02771
FFLINLSTLDILFTT

OR2AT4

66

A6NND4
SSFNVFFALLVTLIS

OR5B17

201

Q8NGF7
LFSSLLRQDITFFDA

ABCB8

231

Q9NUT2
FFLANLSFTDLFFVT

OR1D2

61

P34982
FFLANLSFTDLFFVT

OR1D4

61

P47884
FFLANLSFTDLFFVT

OR1D5

61

P58170
FTTATEFQVLLFLLF

OR10Q1

21

Q8NGQ4
LVSFINFFTSVLATL

SLC6A15

336

Q9H2J7
LFELLNFLAENFIFS

SLC9A6

381

Q92581
LFFSAFLVADSLINV

PTCHD1

711

Q96NR3
LTDLRFLSIDFLNTF

RASGRF2

651

O14827
FLILLSFFISLLDSQ

OR7E24

161

Q6IFN5
LDIAVDFFSFLSQSI

POMGNT1

396

Q8WZA1
SSRIFLFNLAVADFL

HCAR3

61

P49019
LTFSSADLVVFAELF

SMARCAL1

791

Q9NZC9
LADTVFSTQDFLTLF

SIGMAR1

186

Q99720
QLAFFEIFIISELFI

OR8K1

106

Q8NGG5
FFLRNFSFLELLLVT

OR6T1

61

Q8NGN1
TFFQLLLSFFVESKL

STAG3L1

141

P0CL83
FTDNLELQTIFFFLF

OR5T2

56

Q8NGG2
TDLRFLSIDFLNTFL

RASGRF1

661

Q13972
VDSFQIILDSLLFFY

TENT5C

181

Q5VWP2
FSTVVIFLFLLDEQT

CLPTM1L

331

Q96KA5
LLFFCDVDLVFTTEF

CHSY1

626

Q86X52
VEILSFLFQLSFSTL

GTF2H4

231

Q92759
SIFNFLLTVAFAFLV

TMC8

431

Q8IU68
TFFQLLLSFFVESEL

STAG3

476

Q9UJ98
AFLSLLEDSFVQEFL

SPDYC

61

Q5MJ68
ALFFSFLVLLTLDDD

SIDT1

801

Q9NXL6
LFNLALVDEFFTLTL

nan

96

Q7L0L9
LSSLAVSFFELLLFF

ZNF654

106

Q8IZM8
FFQVTLFAVNEFILL

RHCG

156

Q9UBD6
SLSFLTVFIFAFVIT

ZDHHC14

216

Q8IZN3
FSLDLLLFSTDILCF

VN1R5

16

Q7Z5H4
ALAVFFLVSTQLFAE

TAC1

6

P20366
ALIFFFIVSNLTIDF

WFS1

326

O76024
TLAFSVTLFTIFAFI

SLC8A1

906

P32418