Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionolfactory receptor activity

OR5P2 OR2M7 OR2T33 OR4F4 OR4D1 OR8H1 OR2T34 OR2T4 OR2T3 OR2T8 OR52B4 OR4F5 OR51Q1 OR51B6 OR1Q1 OR6C75 OR4F17 OR52Z1P OR52B6 OR2A2

4.64e-1343111420GO:0004984
GeneOntologyMolecularFunctionG protein-coupled receptor activity

OR5P2 OR2M7 OR2T33 OR4F4 OR4D1 OR8H1 ADGRV1 OR2T34 OR2T4 OR2T3 OR2T8 OR52B4 OR4F5 OR51Q1 OR51B6 OR1Q1 OR6C75 OR4F17 ADGRE1 OR52Z1P OR52B6 OR2A2

4.81e-0988411422GO:0004930
GeneOntologyMolecularFunctiontransmembrane signaling receptor activity

OR5P2 OR2M7 OR2T33 NTRK3 OR4F4 OR4D1 OR8H1 GRIN1 ADGRV1 OR2T34 OR2T4 OR2T3 OR2T8 OR52B4 OR4F5 OR51Q1 OR51B6 OR1Q1 OR6C75 OR4F17 ADGRE1 OR52Z1P OR52B6 GABRA3 OR2A2

1.35e-07135311425GO:0004888
GeneOntologyMolecularFunctionminus-end-directed microtubule motor activity

DNAH7 DNAH1 DNAH8 DNAH11

2.90e-06181144GO:0008569
GeneOntologyMolecularFunctiondynein light intermediate chain binding

DNAH7 DNAH1 DNAH8 DNAH11

1.86e-05281144GO:0051959
GeneOntologyMolecularFunctiondynein intermediate chain binding

DNAH7 DNAH1 DNAH8 DNAH11

5.75e-05371144GO:0045505
GeneOntologyMolecularFunctionarylamine N-acetyltransferase activity

NAT1 NAT2

9.66e-0531142GO:0004060
GeneOntologyMolecularFunctionamino acid transmembrane transporter activity

NAT1 NAT2 GRIN1 SLC1A3 SLC16A2

3.40e-041051145GO:0015171
GeneOntologyMolecularFunctionmicrotubule motor activity

DNAH7 DNAH1 DNAH8 DNAH11

6.91e-04701144GO:0003777
GeneOntologyMolecularFunctionATP-dependent activity

TDRD9 RNF213 CHD4 DNAH7 DHX8 DNAH1 ACSF3 DNAH8 ABCC10 ATP6V0A2 DNAH11

7.80e-0461411411GO:0140657
GeneOntologyMolecularFunctionmannosyl-oligosaccharide 1,2-alpha-mannosidase activity

MAN1A2 EDEM1

8.85e-0481142GO:0004571
GeneOntologyMolecularFunctionmannosyl-oligosaccharide mannosidase activity

MAN1A2 EDEM1

1.41e-03101142GO:0015924
GeneOntologyBiologicalProcessdetection of chemical stimulus involved in sensory perception of smell

OR5P2 OR2M7 OR2T33 OR4F4 OR4D1 OR8H1 OR2T34 OR2T4 OR2T3 OR2T8 OR52B4 OR4F5 OR51Q1 OR51B6 OR1Q1 OR6C75 OR4F17 OR52Z1P OR52B6 OR2A2

3.19e-1343211520GO:0050911
GeneOntologyBiologicalProcesssensory perception of smell

OR5P2 OR2M7 OR2T33 OR4F4 OR4D1 OR8H1 OR2T34 OR2T4 OR2T3 OR2T8 OR52B4 OR4F5 OR51Q1 OR51B6 OR1Q1 OR6C75 OR4F17 OR52Z1P OR52B6 OR2A2

1.24e-1246511520GO:0007608
GeneOntologyBiologicalProcessdetection of chemical stimulus involved in sensory perception

OR5P2 OR2M7 OR2T33 OR4F4 OR4D1 OR8H1 OR2T34 OR2T4 OR2T3 OR2T8 OR52B4 OR4F5 OR51Q1 OR51B6 OR1Q1 OR6C75 OR4F17 OR52Z1P OR52B6 OR2A2

2.68e-1248511520GO:0050907
GeneOntologyBiologicalProcessdetection of stimulus involved in sensory perception

OR5P2 OR2M7 OR2T33 OR4F4 OR4D1 OR8H1 ADGRV1 OR2T34 OR2T4 OR2T3 OR2T8 OR52B4 OR4F5 OR51Q1 OR51B6 OR1Q1 OR6C75 OR4F17 OR52Z1P OR52B6 OR2A2

8.99e-1258211521GO:0050906
GeneOntologyBiologicalProcessdetection of chemical stimulus

OR5P2 OR2M7 OR2T33 OR4F4 OR4D1 OR8H1 OR2T34 OR2T4 OR2T3 OR2T8 OR52B4 OR4F5 OR51Q1 OR51B6 OR1Q1 OR6C75 OR4F17 OR52Z1P OR52B6 OR2A2

1.09e-1152411520GO:0009593
GeneOntologyBiologicalProcesssensory perception of chemical stimulus

OR5P2 OR2M7 OR2T33 OR4F4 OR4D1 OR8H1 OR2T34 OR2T4 OR2T3 OR2T8 OR52B4 OR4F5 OR51Q1 OR51B6 OR1Q1 OR6C75 OR4F17 OR52Z1P OR52B6 OR2A2

2.36e-1154711520GO:0007606
GeneOntologyBiologicalProcessdetection of stimulus

OR5P2 OR2M7 OR2T33 OR4F4 OR4D1 OR8H1 ADGRV1 OR2T34 OR2T4 OR2T3 OR2T8 OR52B4 OR4F5 OR51Q1 OR51B6 OR1Q1 OR6C75 OR4F17 OR52Z1P OR52B6 OR2A2

4.78e-1072211521GO:0051606
GeneOntologyBiologicalProcesssensory perception

OR5P2 OR2M7 OR2T33 OR4F4 OR4D1 OR8H1 GRIN1 ADGRV1 OR2T34 OR2T4 SLC1A3 OR2T3 OR2T8 OR52B4 OR4F5 OR51Q1 OR51B6 OR1Q1 OR6C75 LRP2 OR4F17 ULK4 OR52Z1P OR52B6 OR2A2

8.45e-10107211525GO:0007600
GeneOntologyBiologicalProcessG protein-coupled receptor signaling pathway

OR5P2 OR2M7 OR2T33 OR4F4 OR4D1 OR8H1 ADGRV1 OR2T34 OR2T4 OR2T3 OR2T8 OR52B4 OR4F5 PIK3R6 OR51Q1 OR51B6 OR1Q1 OR6C75 OR4F17 ADGRE1 OR52Z1P OR52B6 OR2A2

2.27e-06139511523GO:0007186
DomainOlfact_rcpt

OR5P2 OR2M7 OR2T33 OR4F4 OR4D1 OR8H1 OR2T34 OR2T4 OR2T3 OR2T8 OR52B4 OR4F5 OR51Q1 OR51B6 OR1Q1 OR6C75 OR4F17 OR52B6 OR2A2

2.91e-1239311419IPR000725
DomainGPCR_Rhodpsn_7TM

OR5P2 OR2M7 OR2T33 OR4F4 OR4D1 OR8H1 OR2T34 OR2T4 OR2T3 OR2T8 OR52B4 OR4F5 OR51Q1 OR51B6 OR1Q1 OR6C75 OR4F17 OR52B6 OR2A2

2.24e-0867011419IPR017452
Domain7tm_1

OR5P2 OR2M7 OR2T33 OR4F4 OR4D1 OR8H1 OR2T34 OR2T4 OR2T3 OR2T8 OR52B4 OR4F5 OR51Q1 OR51B6 OR1Q1 OR6C75 OR4F17 OR52B6 OR2A2

2.65e-0867711419PF00001
DomainG_PROTEIN_RECEP_F1_1

OR5P2 OR2M7 OR2T33 OR4F4 OR4D1 OR8H1 OR2T34 OR2T4 OR2T3 OR2T8 OR52B4 OR4F5 OR51Q1 OR51B6 OR1Q1 OR6C75 OR4F17 OR52B6 OR2A2

3.19e-0868511419PS00237
DomainG_PROTEIN_RECEP_F1_2

OR5P2 OR2M7 OR2T33 OR4F4 OR4D1 OR8H1 OR2T34 OR2T4 OR2T3 OR2T8 OR52B4 OR4F5 OR51Q1 OR51B6 OR1Q1 OR6C75 OR4F17 OR52B6 OR2A2

3.66e-0869111419PS50262
DomainGPCR_Rhodpsn

OR5P2 OR2M7 OR2T33 OR4F4 OR4D1 OR8H1 OR2T34 OR2T4 OR2T3 OR2T8 OR52B4 OR4F5 OR51Q1 OR51B6 OR1Q1 OR6C75 OR4F17 OR52B6 OR2A2

3.75e-0869211419IPR000276
DomainDynein_heavy_chain_D4_dom

DNAH7 DNAH1 DNAH8 DNAH11

1.26e-06141144IPR024317
DomainDynein_HC_stalk

DNAH7 DNAH1 DNAH8 DNAH11

1.26e-06141144IPR024743
DomainDynein_heavy_dom-2

DNAH7 DNAH1 DNAH8 DNAH11

1.26e-06141144IPR013602
DomainDHC_N2

DNAH7 DNAH1 DNAH8 DNAH11

1.26e-06141144PF08393
DomainMT

DNAH7 DNAH1 DNAH8 DNAH11

1.26e-06141144PF12777
DomainAAA_8

DNAH7 DNAH1 DNAH8 DNAH11

1.26e-06141144PF12780
DomainDHC_fam

DNAH7 DNAH1 DNAH8 DNAH11

1.71e-06151144IPR026983
DomainDynein_heavy_dom

DNAH7 DNAH1 DNAH8 DNAH11

1.71e-06151144IPR004273
DomainDynein_heavy

DNAH7 DNAH1 DNAH8 DNAH11

1.71e-06151144PF03028
DomainArylamine_N-AcTrfase

NAT1 NAT2

3.69e-0521142IPR001447
DomainSIM_C

SIM1 SIM2

3.69e-0521142IPR010578
DomainAcetyltransf_2

NAT1 NAT2

3.69e-0521142PF00797
DomainSIM_C

SIM1 SIM2

3.69e-0521142PF06621
DomainSIM_C

SIM1 SIM2

3.69e-0521142PS51302
DomainATPase_dyneun-rel_AAA

DNAH1 DNAH8 DNAH11

7.68e-05141143IPR011704
DomainAAA_5

DNAH1 DNAH8 DNAH11

7.68e-05141143PF07728
DomainDUF1981

ARFGEF2 ARFGEF1

2.20e-0441142PF09324
DomainSec7_N

ARFGEF2 ARFGEF1

2.20e-0441142IPR032691
DomainSec7_N

ARFGEF2 ARFGEF1

2.20e-0441142PF12783
DomainDCB_dom

ARFGEF2 ARFGEF1

2.20e-0441142IPR032629
DomainDCB

ARFGEF2 ARFGEF1

2.20e-0441142PF16213
DomainSec7_C

ARFGEF2 ARFGEF1

2.20e-0441142IPR015403
DomainARM-type_fold

SAAL1 NBEAL1 APC ARFGEF2 ARFGEF1 ANKAR ULK4 TTI1 XPO7

2.34e-043391149IPR016024
DomainARM-like

SAAL1 APC ARFGEF2 ARFGEF1 ANKAR ULK4 TTI1 XPO7

2.52e-042701148IPR011989
Domain-

SAAL1 APC ARFGEF2 ARFGEF1 ANKAR ULK4 TTI1

4.28e-0422211471.25.10.10
DomainGlyco_hydro_47

MAN1A2 EDEM1

7.60e-0471142PF01532
Domain-

MAN1A2 EDEM1

7.60e-04711421.50.10.50
DomainDHC_N1

DNAH8 DNAH11

1.01e-0381142PF08385
DomainDynein_heavy_dom-1

DNAH8 DNAH11

1.01e-0381142IPR013594
DomainGlyco_hydro_47

MAN1A2 EDEM1

1.01e-0381142IPR001382
DomainAAA+_ATPase

RNF213 DNAH7 DNAH8 ABCC10 DNAH11

1.90e-031441145IPR003593
DomainAAA

RNF213 DNAH7 DNAH8 ABCC10 DNAH11

1.90e-031441145SM00382
Domain-

ARFGEF2 ARFGEF1

3.68e-031511421.10.1000.11
DomainSec7

ARFGEF2 ARFGEF1

3.68e-03151142PF01369
DomainSec7_alpha_orthog

ARFGEF2 ARFGEF1

3.68e-03151142IPR023394
DomainSec7

ARFGEF2 ARFGEF1

4.19e-03161142SM00222
DomainSEC7

ARFGEF2 ARFGEF1

4.19e-03161142PS50190
DomainSec7_dom

ARFGEF2 ARFGEF1

4.19e-03161142IPR000904
DomainHA2

TDRD9 DHX8

5.30e-03181142SM00847
DomainHA2

TDRD9 DHX8

5.30e-03181142PF04408
DomainHelicase-assoc_dom

TDRD9 DHX8

5.30e-03181142IPR007502
PathwayKEGG_OLFACTORY_TRANSDUCTION

OR5P2 OR2M7 OR2T33 OR4F4 OR4D1 OR8H1 OR2T34 OR2T4 OR2T3 OR2T8 OR52B4 OR4F5 OR51Q1 OR51B6 OR1Q1 OR6C75 OR4F17 OR52B6 OR2A2

5.55e-123899219M14091
PathwayREACTOME_OLFACTORY_SIGNALING_PATHWAY

OR5P2 OR2M7 OR2T33 OR4F4 OR4D1 OR8H1 OR2T34 OR2T4 OR2T3 OR2T8 OR4F5 OR51Q1 OR51B6 OR1Q1 OR6C75 OR4F17 OR52Z1P OR52B6 OR2A2

1.86e-114179219M4072
PathwayREACTOME_SENSORY_PERCEPTION

OR5P2 OR2M7 OR2T33 OR4F4 OR4D1 OR8H1 OR2T34 OR2T4 OR2T3 OR2T8 OR4F5 OR51Q1 OR51B6 OR1Q1 OR6C75 LRP2 OR4F17 OR52Z1P OR52B6 OR2A2

3.58e-096369220M41834
PathwayKEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_SOD1_TO_RETROGRADE_AXONAL_TRANSPORT

DNAH7 DNAH1 DNAH8 DNAH11

2.66e-0527924M47755
PathwayKEGG_MEDICUS_REFERENCE_RETROGRADE_AXONAL_TRANSPORT

DNAH7 DNAH1 DNAH8 DNAH11

1.73e-0443924M47669
PathwayKEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_HTT_TO_RETROGRADE_AXONAL_TRANSPORT

DNAH7 DNAH1 DNAH8 DNAH11

2.06e-0445924M47670
Pubmed

Different evolutionary processes shaped the mouse and human olfactory receptor gene families.

OR5P2 OR2M7 OR2T33 OR4F4 OR4D1 OR8H1 OR2T4 OR2T8 OR52B4 OR51Q1 OR51B6 OR1Q1 OR6C75 OR52Z1P OR2A2

6.72e-133401171511875048
Pubmed

The olfactory receptor gene superfamily of the mouse.

OR5P2 OR2M7 OR2T33 OR4F4 OR4D1 OR8H1 OR2T4 OR2T8 OR52B4 OR51Q1 OR51B6 OR1Q1 OR6C75 OR52Z1P OR2A2

6.72e-133401171511802173
Pubmed

A unified nomenclature for vertebrate olfactory receptors.

OR5P2 OR2M7 OR2T33 OR4F4 OR4D1 OR8H1 OR2T4 OR2T8 OR52B4 OR51Q1 OR51B6 OR1Q1 OR6C75 OR52Z1P OR2A2

7.62e-133431171532295537
Pubmed

Odorant receptor expressed sequence tags demonstrate olfactory expression of over 400 genes, extensive alternate splicing and unequal expression levels.

OR5P2 OR2M7 OR2T33 OR4F4 OR4D1 OR8H1 OR2T4 OR2T8 OR52B4 OR51Q1 OR51B6 OR1Q1 OR6C75 OR52Z1P OR2A2

8.64e-133461171514611657
Pubmed

The human olfactory receptor gene family.

OR5P2 OR2M7 OR2T33 OR4F4 OR4D1 OR8H1 OR2T34 OR2T4 OR52B4 OR1Q1 OR52Z1P OR52B6 OR2A2

3.84e-085411171314983052
Pubmed

Identification of dynein heavy chain genes expressed in human and mouse testis: chromosomal localization of an axonemal dynein gene.

DNAH7 DNAH1 DNAH8 DNAH11

1.19e-071411749373155
Pubmed

CDK8 and CDK19 act redundantly to control the CFTR pathway in the intestinal epithelium.

POLR2A CDK19 APC

3.69e-075117336545778
Pubmed

Polymorphisms and colorectal tumor risk.

NAT1 NAT2 APC

1.29e-067117311487538
Pubmed

Isolation of several human axonemal dynein heavy chain genes: genomic structure of the catalytic site, phylogenetic analysis and chromosomal assignment.

DNAH1 DNAH8 DNAH11

1.29e-06711739256245
Pubmed

SARS-CoV-2 Nsp6 damages Drosophila heart and mouse cardiomyocytes through MGA/MAX complex-mediated increased glycolysis.

SAAL1 COPB2 ARFGEF1 CHD4 SLC1A3 PCGF6 CEPT1 SF3B3 NUP210 TTI1 ATP6V0A2 XPO7

2.36e-066571171236180527
Pubmed

Adenomatous polyposis coli control of C-terminal binding protein-1 stability regulates expression of intestinal retinol dehydrogenases.

APC CTBP1

1.12e-052117217028196
Pubmed

Are polymorphisms of N-acetyltransferase genes susceptible to primary liver cancer in Luoyang, China?

NAT1 NAT2

1.12e-052117215770721
Pubmed

Meat and heterocyclic amine intake, smoking, NAT1 and NAT2 polymorphisms, and colorectal cancer risk in the multiethnic cohort study.

NAT1 NAT2

1.12e-052117219549810
Pubmed

SIM2 maintains innate host defense of the small intestine.

APC SIM2

1.12e-052117225277798
Pubmed

Structural basis of substrate-binding specificity of human arylamine N-acetyltransferases.

NAT1 NAT2

1.12e-052117217656365
Pubmed

N-acetyltransferase 1 and 2 genotypes do not predict response or toxicity to treatment with mesalamine and sulfasalazine in patients with ulcerative colitis.

NAT1 NAT2

1.12e-052117212135032
Pubmed

Deficiency of N-acetyltransferase increases the interactions of isoniazid with endobiotics in mouse liver.

NAT1 NAT2

1.12e-052117228888949
Pubmed

Hair dye use, genetic variation in N-acetyltransferase 1 (NAT1) and 2 (NAT2), and risk of non-Hodgkin lymphoma.

NAT1 NAT2

1.12e-052117217522066
Pubmed

Site-directed mutagenesis of recombinant human arylamine N-acetyltransferase expressed in Escherichia coli. Evidence for direct involvement of Cys68 in the catalytic mechanism of polymorphic human NAT2.

NAT1 NAT2

1.12e-05211721559981
Pubmed

Genetic polymorphisms of arylamine N-acetyltransferases 1 and 2 and the likelihood of developing pediatric acute lymphoblastic leukemia.

NAT1 NAT2

1.12e-052117229214875
Pubmed

N-acetyltransferase 1 and 2 polymorphisms and risk of diabetes mellitus type 2 in a Saudi population.

NAT1 NAT2

1.12e-052117226409796
Pubmed

Effects of microRNA-217 on proliferation, apoptosis, and autophagy of hepatocytes in rat models of CCL4-induced liver injury by targeting NAT2.

NAT1 NAT2

1.12e-052117230417525
Pubmed

Relevance of N-acetyltransferase 1 and 2 (NAT1, NAT2) genetic polymorphisms in non-small cell lung cancer susceptibility.

NAT1 NAT2

1.12e-052117211266080
Pubmed

N-acetyltransferase SNPs: emerging concepts serve as a paradigm for understanding complexities of personalized medicine.

NAT1 NAT2

1.12e-052117219379125
Pubmed

Mechanism by which arylamine N-acetyltransferase 1 ablation causes insulin resistance in mice.

NAT1 NAT2

1.12e-052117229237750
Pubmed

Genetic regulation of aromatic amine N-acetylation in inbred mice.

NAT1 NAT2

1.12e-05211726976963
Pubmed

Update on consensus arylamine N-acetyltransferase gene nomenclature.

NAT1 NAT2

1.12e-052117210862519
Pubmed

Glucocorticoid receptor-mediated transcriptional regulation of N-acetyltransferase 1 gene through distal promoter.

NAT1 NAT2

1.12e-052117222644701
Pubmed

Molecular genetic basis of rapid and slow acetylation in mice.

NAT1 NAT2

1.12e-05211721875909
Pubmed

NAT gene polymorphisms and susceptibility to Alzheimer's disease: identification of a novel NAT1 allelic variant.

NAT1 NAT2

1.12e-052117215142281
Pubmed

5-methyl-tetrahydrofolate and the S-adenosylmethionine cycle in C57BL/6J mouse tissues: gender differences and effects of arylamine N-acetyltransferase-1 deletion.

NAT1 NAT2

1.12e-052117224205029
Pubmed

Deletion of a xenobiotic metabolizing gene in mice affects folate metabolism.

NAT1 NAT2

1.12e-052117217961509
Pubmed

Sequence variants of NAT1 and NAT2 and other xenometabolic genes and risk of lung and aerodigestive tract cancers in Central Europe.

NAT1 NAT2

1.12e-052117218199719
Pubmed

Polymorphisms of arylamine N-acetyltransferase (NAT1 and NAT2) and larynx cancer susceptibility.

NAT1 NAT2

1.12e-052117212037388
Pubmed

Cloning of two human homologs of the Drosophila single-minded gene SIM1 on chromosome 6q and SIM2 on 21q within the Down syndrome chromosomal region.

SIM1 SIM2

1.12e-05211729199934
Pubmed

Single-minded--two genes, three chromosomes.

SIM1 SIM2

1.12e-05211729199929
Pubmed

N-acetyltransferase 1 and 2 gene sequence variants and risk of head and neck cancer.

NAT1 NAT2

1.12e-052117219898993
Pubmed

Effects of genetic polymorphisms of N-Acetyltransferase on trichloroethylene-induced hypersensitivity dermatitis among exposed workers.

NAT1 NAT2

1.12e-052117219834256
Pubmed

Carcinogen metabolism, cigarette smoking, and breast cancer risk: a Bayes model averaging approach.

NAT1 NAT2

1.12e-052117221080951
Pubmed

Association of arylamine N-acetyltransferase (NAT1 and NAT2) genotypes with urinary bladder cancer risk.

NAT1 NAT2

1.12e-052117214564055
Pubmed

Haplotype of N-acetyltransferase 1 and 2 and risk of pancreatic cancer.

NAT1 NAT2

1.12e-052117218006927
Pubmed

Arf guanine nucleotide-exchange factors BIG1 and BIG2 regulate nonmuscle myosin IIA activity by anchoring myosin phosphatase complex.

ARFGEF2 ARFGEF1

1.12e-052117223918382
Pubmed

Overexpression of mSim2 gene in the zona limitans of the diencephalon of segmental trisomy 16 Ts1Cje fetuses, a mouse model for trisomy 21: a novel whole-mount based RNA hybridization study.

SIM1 SIM2

1.12e-052117210837894
Pubmed

Identification and validation of N-acetyltransferase 2 as an insulin sensitivity gene.

NAT1 NAT2

1.12e-052117225798622
Pubmed

RNAi-mediated knock-down of arylamine N-acetyltransferase-1 expression induces E-cadherin up-regulation and cell-cell contact growth inhibition.

NAT1 NAT2

1.12e-052117221347396
Pubmed

Regulation of brefeldin A-inhibited guanine nucleotide-exchange protein 1 (BIG1) and BIG2 activity via PKA and protein phosphatase 1gamma.

ARFGEF2 ARFGEF1

1.12e-052117217360629
Pubmed

Nat1 promotes translation of specific proteins that induce differentiation of mouse embryonic stem cells.

NAT1 NAT2

1.12e-052117228003464
Pubmed

Identification and localization of two brefeldin A-inhibited guanine nucleotide-exchange proteins for ADP-ribosylation factors in a macromolecular complex.

ARFGEF2 ARFGEF1

1.12e-052117210716990
Pubmed

Combined effects of well-done red meat, smoking, and rapid N-acetyltransferase 2 and CYP1A2 phenotypes in increasing colorectal cancer risk.

NAT1 NAT2

1.12e-052117211751443
Pubmed

Arylamine N-acetyltransferase 2 expression in the developing heart.

NAT1 NAT2

1.12e-052117215872051
Pubmed

N-acetyltransferase polymorphisms are associated with risk of lymphoma subtypes.

NAT1 NAT2

1.12e-052117225689677
Pubmed

Association of prostate cancer with rapid N-acetyltransferase 1 (NAT1*10) in combination with slow N-acetyltransferase 2 acetylator genotypes in a pilot case-control study.

NAT1 NAT2

1.12e-052117212355549
Pubmed

Membrane association of the Arabidopsis ARF exchange factor GNOM involves interaction of conserved domains.

ARFGEF2 ARFGEF1

1.12e-052117218203920
Pubmed

An N-ethyl-N-nitrosourea-induced mutation in N-acetyltransferase 1 in mice.

NAT1 NAT2

1.12e-052117218373979
Pubmed

Characterization of N-acetyltransferase 1 and 2 polymorphisms and haplotype analysis for inflammatory bowel disease and sporadic colorectal carcinoma.

NAT1 NAT2

1.12e-052117217537267
Pubmed

Smoking, variation in N-acetyltransferase 1 (NAT1) and 2 (NAT2), and risk of non-Hodgkin lymphoma: a pooled analysis within the InterLymph consortium.

NAT1 NAT2

1.12e-052117223160945
Pubmed

Structural analysis of the genes for human arylamine N-acetyltransferases and characterisation of alternative transcripts.

NAT1 NAT2

1.12e-052117215853926
Pubmed

In silico sequence analysis of arylamine N-acetyltransferases: evidence for an absence of lateral gene transfer from bacteria to vertebrates and first description of paralogs in bacteria.

NAT1 NAT2

1.12e-052117212054539
Pubmed

Acetylation genotype and the genetic susceptibility to prostate cancer in a southern European population.

NAT1 NAT2

1.12e-052117215717312
Pubmed

Structure and restriction fragment length polymorphism of genes for human liver arylamine N-acetyltransferases.

NAT1 NAT2

1.12e-05211721676262
Pubmed

Arylamine N-acetyltransferases: a structural perspective.

NAT1 NAT2

1.12e-052117223517104
Pubmed

No apparent association between NAT1 and NAT2 genotypes and risk of stomach cancer.

NAT1 NAT2

1.12e-052117212692115
Pubmed

Transcriptional activity of multiple copies of a subtelomerically located olfactory receptor gene that is polymorphic in number and location.

OR4F4 OR4F17

1.12e-052117211689484
Pubmed

Comparative sequencing of a multicopy subtelomeric region containing olfactory receptor genes reveals multiple interactions between non-homologous chromosomes.

OR4F4 OR4F17

1.12e-052117211689483
Pubmed

Chromosomal localization of human genes for arylamine N-acetyltransferase.

NAT1 NAT2

1.12e-05211728110178
Pubmed

Major effects on teratogen-induced facial clefting in mice determined by a single genetic region.

NAT1 NAT2

1.12e-05211722227380
Pubmed

Differences in N-acetylation genotypes between Caucasians and Black South Africans: implications for cancer prevention.

NAT1 NAT2

1.12e-052117212088198
Pubmed

Redundant roles of BIG2 and BIG1, guanine-nucleotide exchange factors for ADP-ribosylation factors in membrane traffic between the trans-Golgi network and endosomes.

ARFGEF2 ARFGEF1

1.12e-052117218417613
Pubmed

Developmental expression of N-acetyltransferases in C57BI/6 mice.

NAT1 NAT2

1.12e-05211729929513
Pubmed

Impairment of the activity of the xenobiotic-metabolizing enzymes arylamine N-acetyltransferases 1 and 2 (NAT1/NAT2) by peroxynitrite in mouse skeletal muscle cells.

NAT1 NAT2

1.12e-052117216098511
Pubmed

Cloning, sequencing, and recombinant expression of NAT1, NAT2, and NAT3 derived from the C3H/HeJ (rapid) and A/HeJ (slow) acetylator inbred mouse: functional characterization of the activation and deactivation of aromatic amine carcinogens.

NAT1 NAT2

1.12e-05211729070359
Pubmed

Association between polymorphisms at N-acetyltransferase 1 (NAT1) & risk of oral leukoplakia & cancer.

NAT1 NAT2

1.12e-052117223168701
Pubmed

Association of NAT1 and NAT2 genes with nonsyndromic cleft lip and palate.

NAT1 NAT2

1.12e-052117223660777
Pubmed

Characterisation of CpG methylation in the upstream control region of mouse Nat2: evidence for a gene-environment interaction in a polymorphic gene implicated in folate metabolism.

NAT1 NAT2

1.12e-052117220026257
Pubmed

N-acetyl transferase genotypes in relation to risk of developing systemic lupus erythematosus.

NAT1 NAT2

1.12e-052117214705222
Pubmed

[The biological role of prokaryotic and eukaryotic N-acetyltransferase].

NAT1 NAT2

1.12e-052117223420430
Pubmed

A readout of metabolic efficiency in arylamine N-acetyltransferase-deficient mice reveals minor energy metabolism changes.

NAT1 NAT2

1.12e-052117230883722
Pubmed

Genetic polymorphisms of the N-acetyltransferase genes and risk of Parkinson's disease.

NAT1 NAT2

1.12e-052117212682333
Pubmed

Maternal smoking and the risk of orofacial clefts: Susceptibility with NAT1 and NAT2 polymorphisms.

NAT1 NAT2

1.12e-052117215127906
Pubmed

Joint effects of the N-acetyltransferase 1 and 2 (NAT1 and NAT2) genes and smoking on bladder carcinogenesis: a literature-based systematic HuGE review and evidence synthesis.

NAT1 NAT2

1.12e-052117217675654
Pubmed

Arylamine N-acetyltransferase polymorphisms in Han Chinese patients with ankylosing spondylitis and their correlation to the adverse drug reactions to sulfasalazine.

NAT1 NAT2

1.12e-052117225413361
Pubmed

Genetic variation in N-acetyltransferase 1 (NAT1) and 2 (NAT2) and risk of non-Hodgkin lymphoma.

NAT1 NAT2

1.12e-052117216847422
Pubmed

Tissue- and gender-specific expression of N-acetyltransferase 2 (Nat2*) during development of the outbred mouse strain CD-1.

NAT1 NAT2

1.12e-052117210640510
Pubmed

NMDA Receptor Expression by Retinal Ganglion Cells Is Not Required for Retinofugal Map Formation nor Eye-Specific Segregation in the Mouse.

POLR2A GRIN1

1.12e-052117234193509
Pubmed

Well-done meat consumption, NAT1 and NAT2 acetylator genotypes and prostate cancer risk: the multiethnic cohort study.

NAT1 NAT2

1.12e-052117220570911
Pubmed

Para-phenylenediamine and allergic sensitization: risk modification by N-acetyltransferase 1 and 2 genotypes.

NAT1 NAT2

1.12e-052117219663877
Pubmed

Nomenclature for N-acetyltransferases.

NAT1 NAT2

1.12e-05211727773298
Pubmed

NAT1 and NAT2 genetic polymorphisms and environmental exposure as risk factors for oesophageal squamous cell carcinoma: a case-control study.

NAT1 NAT2

1.12e-052117225886288
Pubmed

Role of N-acetyltransferase polymorphisms in hepatitis B related hepatocellular carcinoma: impact of smoking on risk.

NAT1 NAT2

1.12e-052117211034589
Pubmed

Cigarette smoking, N-acetyltransferase genes and the risk of advanced colorectal adenoma.

NAT1 NAT2

1.12e-052117216981843
Pubmed

Generation and functional characterization of arylamine N-acetyltransferase Nat1/Nat2 double-knockout mice.

NAT1 NAT2

1.12e-052117212815173
Pubmed

Identification and functional characterization of novel polymorphisms associated with the genes for arylamine N-acetyltransferases in mice.

NAT1 NAT2

1.12e-052117212142728
Pubmed

Reduced 4-aminobiphenyl-induced liver tumorigenicity but not DNA damage in arylamine N-acetyltransferase null mice.

NAT1 NAT2

1.12e-052117222193722
Pubmed

Prospective study of NAT1 and NAT2 polymorphisms, tobacco smoking and meat consumption and risk of colorectal cancer.

NAT1 NAT2

1.12e-052117218372103
Pubmed

Modification by N-acetyltransferase 1 genotype on the association between dietary heterocyclic amines and colon cancer in a multiethnic study.

NAT1 NAT2

1.12e-052117218022202
Pubmed

Association of NAT1 and NAT2 polymorphisms to urinary bladder cancer: significantly reduced risk in subjects with NAT1*10.

NAT1 NAT2

1.12e-052117211431340
Pubmed

Functional expression of human arylamine N-acetyltransferase NAT1*10 and NAT1*11 alleles: a mini review.

NAT1 NAT2

1.12e-052117230222709
Pubmed

Arylamine N-acetyl transferase in mice.

NAT1 NAT2

1.12e-05211721397516
Pubmed

Generation and analysis of mice with a targeted disruption of the arylamine N-acetyltransferase type 2 gene.

NAT1 NAT2

1.12e-052117212815365
Pubmed

NAT2 variation and idiopathic talipes equinovarus (clubfoot).

NAT1 NAT2

1.12e-052117217726690
CytobandEnsembl 112 genes in cytogenetic band chr11p15

OR5P2 UBQLNL ANO9 AMPD3 SAAL1 IFITM1 OR52B4 OR51Q1 OR51B6 OR52Z1P OR52B6

2.34e-0756411711chr11p15
Cytoband1q44

OR2M7 OR2T33 OR2T34 OR2T4 OR2T3 OR2T8

4.15e-0711011761q44
Cytoband11p15.4

OR5P2 UBQLNL OR52B4 OR51Q1 OR51B6 OR52Z1P OR52B6

8.87e-07200117711p15.4
CytobandEnsembl 112 genes in cytogenetic band chr1q44

OR2M7 OR2T33 OR2T34 OR2T4 OR2T3 OR2T8

1.01e-061281176chr1q44
GeneFamilyDyneins, axonemal

DNAH7 DNAH1 DNAH8 DNAH11

1.48e-0617934536
GeneFamilyOlfactory receptors, family 2

OR2M7 OR2T33 OR2T34 OR2T4 OR2T3 OR2T8 OR2A2

1.88e-06113937149
GeneFamilyArylamine N-acetyltransferases

NAT1 NAT2

7.83e-0539321133
GeneFamilyOlfactory receptors, family 52

OR52B4 OR52Z1P OR52B6

2.05e-0349933165
Diseaseoccupational dermatitis (is_implicated_in)

NAT1 NAT2

1.23e-0521042DOID:4404 (is_implicated_in)
Diseaseadenocarcinoma (is_implicated_in)

NAT1 APC

7.35e-0541042DOID:299 (is_implicated_in)
Diseasediastolic blood pressure, unipolar depression

NAT1 NAA25 ULK4

1.61e-04301043EFO_0003761, EFO_0006336
DiseaseEye Diseases, Hereditary

INPP5E LRP2

1.83e-0461042C0015398
Diseaseallergic contact dermatitis (is_implicated_in)

NAT1 NAT2

1.83e-0461042DOID:3042 (is_implicated_in)
DiseaseIntellectual Disability

TANC2 INPP5E APC GRIN1 MED13L KLHL15 LRP2 CACNA1G

1.89e-044471048C3714756
DiseaseIndustrial Dermatosis

NAT1 NAT2

3.40e-0481042C0086457
DiseaseDermatitis, Occupational

NAT1 NAT2

3.40e-0481042C0028796
Disease5-acetylamino-6-formylamino-3-methyluracil measurement

NAT1 NAT2

4.36e-0491042EFO_0800950
DiseasePrimary Ciliary Dyskinesia

INPP5E DNAH1 DNAH11

6.16e-04471043C4551720
Diseaseend stage renal disease (biomarker_via_orthology)

NAT1 NAT2 LRP2

6.16e-04471043DOID:783 (biomarker_via_orthology)
Disease1-methylxanthine measurement

NAT2 AMPD3

6.63e-04111042EFO_0021174
Disease5-acetylamino-6-amino-3-methyluracil measurement

NAT1 NAT2

6.63e-04111042EFO_0800951
DiseaseAL amyloidosis

ULK4 DNAH11

7.94e-04121042MONDO_0019438
DiseaseN-acetylputrescine measurement

NAT1 NAT2

7.94e-04121042EFO_0800127
Diseaseprostate cancer (is_implicated_in)

NAT1 NAT2 APC IKBKB

7.95e-041171044DOID:10283 (is_implicated_in)
Diseasemultiple myeloma, monoclonal gammopathy

ULK4 DNAH11

1.09e-03141042EFO_0000203, EFO_0001378
Diseaseblood urea nitrogen measurement

PDE1A ADGRV1 SIM1 DHX8 NAA25 LRP2 ABCC10

1.12e-034521047EFO_0004741
Diseasecutaneous melanoma, hair color

AMPD3 ADGRV1 MED13L

1.38e-03621043EFO_0000389, EFO_0003924
DiseaseMental Retardation, Psychosocial

INPP5E APC MED13L CACNA1G

1.51e-031391044C0025363
DiseaseProfound Mental Retardation

INPP5E APC MED13L CACNA1G

1.51e-031391044C0020796
DiseaseMental deficiency

INPP5E APC MED13L CACNA1G

1.51e-031391044C0917816
Diseasestroke

NBEAL1 NAA25 ULK4 UVRAG

1.71e-031441044EFO_0000712
Diseasechildhood trauma measurement, alcohol consumption measurement

TANC2 INTU SIM2

2.04e-03711043EFO_0007878, EFO_0007979
Diseasetransitional cell carcinoma (is_implicated_in)

NAT2 APC

2.71e-03221042DOID:2671 (is_implicated_in)
Diseasecholangiocarcinoma (is_implicated_in)

NAT2 APC

2.71e-03221042DOID:4947 (is_implicated_in)
Diseasecortical surface area measurement

TANC2 PRTG INTU NBEAL1 INPP5E APC ADGRV1 MED13L MAST2 DNAH7 PCGF6 DNAH11

2.77e-03134510412EFO_0010736
Diseasehematocrit

NRIP1 AMPD3 NBEAL1 ADGRV1 SIM1 SIM2 MAST2 LRP2 ULK4 ANKRD52

3.05e-03101110410EFO_0004348
Diseasecystatin C measurement

PDE1A INTU ADGRV1 DNAH1 NAA25 LRP2

3.05e-034021046EFO_0004617
Diseasesnoring measurement

POLR2A ADGRV1 SIM1

3.30e-03841043EFO_0008341

Protein segments in the cluster

PeptideGeneStartEntry
LHYTTLRTLTGQDTM

KCTD13

51

Q8WZ19
LKNYLSEATIGLHTM

ALG11

381

Q2TAA5
YSTGMIHLLLQVTID

NAT1

101

P18440
TSLHSNAAITMIYLG

ERICH3

281

Q5RHP9
DATLSHGILIVMYSS

DCAF17

216

Q5H9S7
HGILIVMYSSGLVRL

DCAF17

221

Q5H9S7
SMVKSLLYQILDGIH

CDK19

126

Q9BWU1
VLNEAVGALMYHTIT

CTBP1

66

Q13363
IVTIAHLDRTMYLLG

COPB2

551

P35606
VLAYSIIMLTTDLHS

ARFGEF1

826

Q9Y6D6
IAHILLIGQDMSALY

ADGRV1

3516

Q8WXG9
VLAYSIIMLTTDLHS

ARFGEF2

771

Q9Y6D5
YITLTQSLHLTMSGA

DNAH11

1876

Q96DT5
ITGHTLLERYGMTEI

ACSF3

346

Q4G176
GYHLLQSDSMLLVLS

FBXL6

36

Q8N531
TGALVHYVTIIIMTK

ANO9

381

A1A5B4
AARYGHELLISTLMT

ANKRD52

346

Q8NB46
VYTGNMTLAAIAVHL

ADNP2

921

Q6IQ32
FHSIGVVIMTSSYLL

ARIH2OS

271

Q8N7S6
LETYTVDMSHILALI

AMPD3

251

Q01432
GIHNSVGILYSMLLE

SLC16A2

116

P36021
LLITISMNYVIGTHG

NBEAL1

2346

Q6ZS30
LMGYVVVGLSLVHTV

NOX5

316

Q96PH1
LIIISYTMILHSVFQ

OR52Z1P

196

P0C646
QQYLILESGIMTISI

ANKAR

1161

Q7Z5J8
ALLAGTAVMIIAYHT

NUP210

1816

Q8TEM1
IFITYVLMGHQLTAT

ABCC10

521

Q5T3U5
AHSLYVTLILSDSVM

MED13L

1106

Q71F56
IMKSIGEAIQYLHSI

MAPKAPK2

166

P49137
ILYMSAAVLQVHATI

MALL

101

Q13021
LVHILNMVTGTIHTY

IKBKB

311

O14920
VLLSSAAHGVLYMSL

INPP5E

361

Q9NRR6
LHTLNAVDMELYTGL

NTRK3

91

Q16288
TSYARVILAVIHMGS

OR2M7

216

Q8NG81
ISSSYLLILLTIHGM

OR2T4

246

Q8NH00
FIHTLSVMESGVLLA

OR51B6

101

Q9H340
YGLILAAVLHMRSTE

OR2T8

216

A6NH00
LYTISIMGNTTILTV

OR51Q1

36

Q8NH59
IHSTFISESGILLVM

OR52B4

106

Q8NGK2
TGLDIMLITVSYIHI

OR52B6

226

Q8NGF0
LLIISYTIILMTIQH

OR4F5

206

Q8NH21
DVTQTVHYIMLHTGI

PDE1A

226

P54750
LVQLYETSLVRHGLM

DNAH8

2111

Q96JB1
IVLTYLEGLLMHQAA

NRIP1

16

P48552
KYLDMGTTHITLTTL

LRRC37B

681

Q96QE4
NGTLLYTMRLTIHAE

GABRA3

176

P34903
EMTVIRSGIAYILHL

LRP2

946

P98164
YGLILAAVLHMRSTE

OR2T33

216

Q8NG76
IMVISSSYTLILHLI

OR2T34

216

Q8NGX1
LLIISYTIILMTIQH

OR4F17

206

Q8NGA8
IMVISSSYTLILHLI

OR2T3

216

Q8NH03
ISGMYLGEIVRHILL

HK3

751

P52790
SLILVSYMHILGAIL

OR2A2

211

Q6IF42
LYLQTSETHMLVQGL

PRTG

771

Q2VWP7
PHIIMYLTLQLDSET

INTU

306

Q9ULD6
YILITILKMRSTEGH

OR5P2

216

Q8WZ92
LVLHLSGMVLNAYVT

SMPD2

121

O60906
IQLYETTVVRHGLML

DNAH1

1846

Q9P2D7
VIHDAILLTGIMDTY

ADAM30

226

Q9UKF2
LHIGSVITLAAMIYK

CEPT1

291

Q9Y6K0
YGTIELSMNTVHEIL

KLHL15

91

Q96M94
LILQITTGLFLAMHY

MT-CYB

41

P00156
IAILVNTLSMGIEYH

CACNA1G

751

O43497
MYTVTVIVGLLIHAV

SLC1A3

316

P43003
YVTLQGISHVELNVM

BTBD8

246

Q5XKL5
LDLTTQIVNGTMTLY

DNAH7

2146

Q8WXX0
HTMGTYIVDLLTHLT

GFOD2

176

Q3B7J2
LHVGMDILQSLEKYT

EDEM1

511

Q92611
LMSLTTNLYEGHIEK

MAST2

661

Q6P0Q8
TIVDALDTLYIMGLH

MAN1A2

226

O60476
YSTGMVHLLLQVTID

NAT2

101

P11245
HVLLTSYELITIDMA

CHD4

846

Q14839
VYMHILQLLTTVDDG

SAAL1

266

Q96ER3
YLDASLITVMQIHLT

DHX8

756

Q14562
ISYTVILVMLRSHSG

OR4D1

216

Q15615
VTYMLSVTGNLIIIT

OR6C75

31

A6NL08
MQDGLLVLHYGLVVS

PCGF6

331

Q9BYE7
TYDIEIMIHILAGST

OR8H1

191

Q8NGG4
ILLLVFGSVTVYHIM

IFITM1

101

P13164
FGSVTVYHIMLQIIQ

IFITM1

106

P13164
STYLNTLMIHTEGAV

OR1Q1

191

Q15612
LLIISYTIILMTIQH

OR4F4

206

Q96R69
QELYLMSHSVSLKGI

FAM83G

301

A6ND36
VLGMSAVISSVAHYL

RNF139

291

Q8WU17
MHISVIISALIATLY

SLC5A7

161

Q9GZV3
AVALGYTAHLVSMIS

UVRAG

361

Q9P2Y5
GEINYMHELLTSLVH

TDRD9

396

Q8NDG6
TTALAIYHVIMSVLL

LAPTM5

21

Q13571
LTEAMYTNLHAVLLG

PTGIS

136

Q16647
LLHTVMYVLTKATGI

PIK3R6

76

Q5UE93
IMYISETASVHLGLS

SIM2

101

Q14190
IMYISETASVHLGLS

SIM1

101

P81133
VQSHLGYTEMVALLL

TANC2

891

Q9HCD6
VLMSLLHLGAVYSLV

SCD5

51

Q86SK9
MLILYNVTHILSSGK

SEC31B

96

Q9NQW1
LTMDFSLYIISHVGI

ADGRE1

596

Q14246
SHLGTKVEMVYSLLS

APC

306

P25054
LLEGHTLLALATTMY

SPG11

1076

Q96JI7
ILTIYPQVLHSLMEA

RNF213

3831

Q63HN8
MLENISHLVSLGYQI

ZNF705A

36

Q6ZN79
LVMKDILYLSEHQGT

ZNF549

111

Q6P9A3
MEILHSIQKGVYVTV

RNF148

161

Q8N7C7
VNELLVYGIHVTMLL

TMEM250

111

H0YL14
SLVHISYLEMGHDIT

POLR2A

651

P24928
GTALLHIYDKVMTVQ

VWA2

611

Q5GFL6
SQRGIMDGHTIYLVI

UBQLNL

86

Q8IYU4
MLENISHLVSLGYQI

ZNF705EP

36

A8MWA4
MLENISHLVSLGYQI

ZNF705G

36

A8MUZ8
VIMNYHVGETVLSLQ

SF3B3

1091

Q15393
MLENISHLVSLGYQI

ZNF705B

36

P0CI00
MLENISHLVSLGYQI

ZNF705D

36

P0CH99
HVIMYILSSISEGLT

XPO7

911

Q9UIA9
IHALLNLMSSSGVSY

YIPF7

186

Q8N8F6
EVMLENYSHLVSLGI

ZNF169

41

Q14929
HVIIITYASLVLVTM

TRPV5

426

Q9NQA5
LLDILHSMLTYTSGI

ULK4

1111

Q96C45
LAVIQGLSTLMHSAY

TTI1

121

O43156
ILMTQVIHSIEYCLG

ATP6V0A2

731

Q9Y487
MYVSISFLLGLSHLV

nan

1

Q8N9W7
MYVSISFLLGLSHLV

nan

1

A6NDX4
QSSYLHSLLEMGELL

NAA25

946

Q14CX7
VGLSVHVVAVMLYLL

GRIN1

566

Q05586