Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	BRCT	NBN TP53BP1	3.39e-04	19	27	2	PF00533
Domain	BRCT	NBN TP53BP1	4.57e-04	22	27	2	SM00292
Domain	-	NBN TP53BP1	5.00e-04	23	27	2	3.40.50.10190
Domain	WD40	NOL10 DCAF8 FBXW9 BRWD1	5.61e-04	268	27	4	SM00320
Domain	WD40_repeat	NOL10 DCAF8 FBXW9 BRWD1	5.93e-04	272	27	4	IPR001680
Domain	BRCT	NBN TP53BP1	6.40e-04	26	27	2	PS50172
Domain	WD_REPEATS_1	NOL10 DCAF8 FBXW9 BRWD1	6.44e-04	278	27	4	PS00678
Domain	WD_REPEATS_2	NOL10 DCAF8 FBXW9 BRWD1	6.52e-04	279	27	4	PS50082
Domain	WD_REPEATS_REGION	NOL10 DCAF8 FBXW9 BRWD1	6.52e-04	279	27	4	PS50294
Domain	BRCT_dom	NBN TP53BP1	7.43e-04	28	27	2	IPR001357
Domain	FHA	NBN KIF1C	7.43e-04	28	27	2	SM00240
Domain	WD40_repeat_dom	NOL10 DCAF8 FBXW9 BRWD1	8.24e-04	297	27	4	IPR017986
Domain	FHA_DOMAIN	NBN KIF1C	9.12e-04	31	27	2	PS50006
Domain	FHA	NBN KIF1C	9.12e-04	31	27	2	PF00498
Domain	FHA_dom	NBN KIF1C	1.23e-03	36	27	2	IPR000253
Domain	-	NBN KIF1C	1.23e-03	36	27	2	2.60.200.20
Domain	-	NOL10 DCAF8 FBXW9 BRWD1	1.26e-03	333	27	4	2.130.10.10
Domain	WD40/YVTN_repeat-like_dom	NOL10 DCAF8 FBXW9 BRWD1	1.29e-03	335	27	4	IPR015943
Domain	SMAD_FHA_domain	NBN KIF1C	2.55e-03	52	27	2	IPR008984
Domain	WD40	DCAF8 FBXW9 BRWD1	6.03e-03	259	27	3	PF00400
Domain	ARM-like	SCYL1 ARMCX3 ARMH4	6.76e-03	270	27	3	IPR011989
Pubmed	Ubiquitin-specific protease 7 sustains DNA damage response and promotes cervical carcinogenesis.	USP7 NBN TP53BP1	5.50e-07	21	27	3	30179224
Pubmed	Distinct kinetics of DNA repair protein accumulation at DNA lesions and cell cycle-dependent formation of γH2AX- and NBS1-positive repair foci.	NBN TP53BP1	1.74e-06	3	27	2	26482424
Pubmed	Fxr1 knockout mice show a striated muscle phenotype: implications for Fxr1p function in vivo.	FXR1 VCL	1.74e-06	3	27	2	15128702
Pubmed	Folliculin variants linked to Birt-Hogg-Dubé syndrome are targeted for proteasomal degradation.	USP7 FLCN	3.48e-06	4	27	2	33137092
Pubmed	Replication independent ATR signalling leads to G2/M arrest requiring Nbs1, 53BP1 and MDC1.	NBN TP53BP1	3.48e-06	4	27	2	18664457
Pubmed	MDC1 regulates intra-S-phase checkpoint by targeting NBS1 to DNA double-strand breaks.	NBN TP53BP1	5.80e-06	5	27	2	18678890
Pubmed	Histone H2AX phosphorylation is dispensable for the initial recognition of DNA breaks.	NBN TP53BP1	5.80e-06	5	27	2	12792649
Pubmed	53BP1 facilitates long-range DNA end-joining during V(D)J recombination.	NBN TP53BP1	5.80e-06	5	27	2	18931658
Pubmed	RNF169 limits 53BP1 deposition at DSBs to stimulate single-strand annealing repair.	NBN TP53BP1	8.69e-06	6	27	2	30104380
Pubmed	Genomic instability in mice lacking histone H2AX.	NBN TP53BP1	8.69e-06	6	27	2	11934988
Pubmed	RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins.	NBN TP53BP1	8.69e-06	6	27	2	18001824
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	USP7 NOL10 FXR1 VCL TP53BP1 NUP88	9.06e-06	653	27	6	22586326
Pubmed	Differential effects on p53-mediated cell cycle arrest vs. apoptosis by p90.	USP7 TP53BP1	1.22e-05	7	27	2	22084066
Pubmed	RNF8 transduces the DNA-damage signal via histone ubiquitylation and checkpoint protein assembly.	NBN TP53BP1	1.22e-05	7	27	2	18001825
Pubmed	BRIT1 regulates early DNA damage response, chromosomal integrity, and cancer.	NBN TP53BP1	1.22e-05	7	27	2	16872911
Pubmed	53BP1 promotes ATM activity through direct interactions with the MRN complex.	NBN TP53BP1	1.62e-05	8	27	2	20010693
Pubmed	DYNLL1 binds to MRE11 to limit DNA end resection in BRCA1-deficient cells.	NBN TP53BP1	1.62e-05	8	27	2	30464262
Pubmed	Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.	USP7 CEP68 NOL10 FXR1 ARMCX3 NUP88	2.04e-05	754	27	6	33060197
Pubmed	A Damage-Independent Role for 53BP1 that Impacts Break Order and Igh Architecture during Class Switch Recombination.	NBN TP53BP1	2.60e-05	10	27	2	27320916
Pubmed	TGFβ pathway is required for viable gestation of Fanconi anemia embryos.	VCL TP53BP1	2.60e-05	10	27	2	36441774
Pubmed	53BP1-dependent robust localized KAP-1 phosphorylation is essential for heterochromatic DNA double-strand break repair.	NBN TP53BP1	3.18e-05	11	27	2	20081839
Pubmed	MDC1 is a mediator of the mammalian DNA damage checkpoint.	NBN TP53BP1	3.18e-05	11	27	2	12607005
Pubmed	Role of genomic instability and p53 in AID-induced c-myc-Igh translocations.	NBN TP53BP1	3.18e-05	11	27	2	16400328
Pubmed	The human cytoplasmic dynein interactome reveals novel activators of motility.	CILK1 NBN VCL KIF1C BRWD1 NUP88	4.07e-05	853	27	6	28718761
Pubmed	Genetic, physical, and transcript map of the Ltxs1 region of mouse chromosome 11.	KIF1C NUP88	4.50e-05	13	27	2	11318612
Pubmed	Mutant p53 interactome identifies nardilysin as a p53R273H-specific binding partner that promotes invasion.	USP7 TP53BP1	5.25e-05	14	27	2	22653443
Pubmed	Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.	USP7 NBN NRIP1 TP53BP1 C19orf47	8.06e-05	588	27	5	38580884
Pubmed	PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex.	NBN TP53BP1	8.81e-05	18	27	2	17500065
Pubmed	A high-throughput approach for measuring temporal changes in the interactome.	USP7 SCYL1 PRUNE2 DCAF8 ARMCX3 VCL NUP88	9.39e-05	1455	27	7	22863883
Pubmed	AMPK Interactome Reveals New Function in Non-homologous End Joining DNA Repair.	CEP68 NBN ARMCX3	1.13e-04	121	27	3	31900314
Pubmed	Interactions of the Antiviral Factor Interferon Gamma-Inducible Protein 16 (IFI16) Mediate Immune Signaling and Herpes Simplex Virus-1 Immunosuppression.	USP7 NOL10 FXR1 NUP88	1.20e-04	332	27	4	25693804
Pubmed	Menin and Menin-Associated Proteins Coregulate Cancer Energy Metabolism.	SCYL1 NBN TP53BP1 NUP88	1.33e-04	341	27	4	32971831
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	USP7 NBN CLSTN2 FXR1 DCAF8 BRWD1	1.79e-04	1116	27	6	31753913
Pubmed	Systematic screening reveals a role for BRCA1 in the response to transcription-associated DNA damage.	USP7 NBN NRIP1	2.09e-04	149	27	3	25184681
Pubmed	WDR76 Co-Localizes with Heterochromatin Related Proteins and Rapidly Responds to DNA Damage.	USP7 NBN NOL10 TP53BP1	2.32e-04	394	27	4	27248496
Pubmed	Cytoplasmic aggregation of DDX1 in developing embryos: Early embryonic lethality associated with Ddx1 knockout.	FXR1 BRWD1	2.33e-04	29	27	2	31330130
Pubmed	Polymorphic variants in hereditary pancreatic cancer genes are not associated with pancreatic cancer risk.	NBN TP53BP1	2.66e-04	31	27	2	19690177
Pubmed	Molecular architecture and assembly of the DDB1-CUL4A ubiquitin ligase machinery.	DCAF8 BRWD1	2.84e-04	32	27	2	16964240
Pubmed	A field synopsis on low-penetrance variants in DNA repair genes and cancer susceptibility.	NBN TP53BP1	3.80e-04	37	27	2	19116388
Pubmed	An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.	SCYL1 CILK1 VCL TP53BP1 KIF1C NUP88	4.42e-04	1321	27	6	27173435
Pubmed	Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells.	USP7 FXR1 ARMCX3 TP53BP1	4.48e-04	469	27	4	27634302
Pubmed	A novel role for the peptidyl-prolyl cis-trans isomerase Cyclophilin A in DNA-repair following replication fork stalling via the MRE11-RAD50-NBS1 complex.	USP7 NBN NOL10 TP53BP1	4.59e-04	472	27	4	38943005
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	PRUNE2 CEP68 CILK1 KIF1C	5.40e-04	493	27	4	15368895
Pubmed	Impaired plasma membrane localization of ubiquitin ligase complex underlies 3-M syndrome development.	PRUNE2 NOL10 KBTBD7 KIF1C	5.53e-04	496	27	4	31343991
Pubmed	Cancer-associated exportin-6 upregulation inhibits the transcriptionally repressive and anticancer effects of nuclear profilin-1.	NBN TP53BP1	5.63e-04	45	27	2	33596420
Pubmed	A probability-based approach for high-throughput protein phosphorylation analysis and site localization.	NBN TP53BP1 KIF1C NUP88	5.83e-04	503	27	4	16964243
Pubmed	Genetic variations strongly influence phenotypic outcome in the mouse retina.	NRIP1 TP53BP1	5.88e-04	46	27	2	21779340
Pubmed	PIKES Analysis Reveals Response to Degraders and Key Regulatory Mechanisms of the CRL4 Network.	DCAF8 BRWD1	6.67e-04	49	27	2	31973889
Pubmed	GREB1: An evolutionarily conserved protein with a glycosyltransferase domain links ERα glycosylation and stability to cancer.	NRIP1 FXR1 ARMCX3	6.79e-04	223	27	3	33731348
Pubmed	N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.	USP7 NBN VCL TP53BP1 NUP88	6.82e-04	934	27	5	33916271
Pubmed	BioID-based Identification of Skp Cullin F-box (SCF)β-TrCP1/2 E3 Ligase Substrates.	FLCN NOL10 PPP1R15B	7.06e-04	226	27	3	25900982
Pubmed	An empirical framework for binary interactome mapping.	NRIP1 DCAF8 ARMCX3	7.52e-04	231	27	3	19060904
Interaction	THOC2 interactions	USP7 FXR1 KBTBD7 VCL TP53BP1 KIF1C C19orf47	1.20e-08	219	27	7	int:THOC2
Interaction	HPSE2 interactions	USP7 KBTBD7 PPP1R15B	4.84e-06	25	27	3	int:HPSE2
Interaction	KIAA1549L interactions	USP7 FXR1	2.58e-05	6	27	2	int:KIAA1549L
Interaction	JAKMIP3 interactions	USP7 NRIP1	2.58e-05	6	27	2	int:JAKMIP3
Interaction	PPP5C interactions	FLCN NOL10 VCL TP53BP1 BRWD1	2.73e-05	272	27	5	int:PPP5C
Interaction	SFRP4 interactions	USP7 DCAF8 KBTBD7	3.79e-05	49	27	3	int:SFRP4
Interaction	SIRT7 interactions	USP7 NOL10 FXR1 KBTBD7 VCL TP53BP1 NUP88	4.23e-05	744	27	7	int:SIRT7
Interaction	ZMYM1 interactions	USP7 PRUNE2 CLSTN2	1.20e-04	72	27	3	int:ZMYM1
Interaction	TRPM1 interactions	USP7 FXR1	1.34e-04	13	27	2	int:TRPM1
Interaction	RNF169 interactions	USP7 NBN TP53BP1	1.41e-04	76	27	3	int:RNF169
Cytoband	17p13.2	KIF1C NUP88	4.85e-04	55	27	2	17p13.2
GeneFamily	WD repeat domain containing\|DDB1 and CUL4 associated factors	DCAF8 BRWD1	1.26e-04	18	17	2	498
GeneFamily	WD repeat domain containing	DCAF8 FBXW9 BRWD1	1.76e-03	262	17	3	362
ToppCell	PCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_immature4_(1)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	FXR1 PPP1R15B VCL NUP88	5.33e-06	193	27	4	dbf0fe496254320c894568c31e5f9ce63707d1b5
Disease	platelet component distribution width	USP7 PRUNE2 CEP68 NRIP1 BRWD1	5.47e-04	755	27	5	EFO_0007984

Protein segments in the cluster

Peptide	Gene	Start	Entry
TESRWKSEEEVESDD	CEP68	466	Q76N32
ETDEDLAWDSDNDSS	C19orf47	271	Q8N9M1
AASALSDEWDDTKLE	ARMH4	306	Q86TY3
TEAAKESEMDWDDSA	CLSTN2	866	Q9H4D0
SDDDDDSNESKSIVW	ARMCX3	61	Q9UH62
SRTWDDDSDPESETD	FBXW9	11	Q5XUX1
SESWDNSEAEEEEKA	FLCN	296	Q8NFG4
TESERKDELSDWSLA	FXR1	411	P51114
KDELSDWSLAGEDDR	FXR1	416	P51114
RNSDEEESASESELW	FRA10AC1	276	Q70Z53
VAEKRDAHWSEDSEA	NUDT9	331	Q9BW91
EDEDKSRERWDAGNS	MUC19	166	Q7Z5P9
DDERALEDWVSSETS	DCAF8	131	Q5TAQ9
SGDDSDKRSCEESWR	KIF1C	676	O43896
DKDIWREASSAESVS	NRIP1	1086	P48552
TEEDDARSESSTEWD	KBTBD7	631	Q8WVZ9
ESSESSDDEKAWVEE	NOL10	546	Q9BSC4
EEDEWRSDRKSESYS	BRWD1	841	Q9NSI6
GEEEDDHTSEKSWDS	NUP88	341	Q99567
TATISDMDNDLDWDD	PRUNE2	1126	Q8WUY3
DKDTAEDSSTADRWD	SCYL1	631	Q96KG9
DTESEQADTWDLSER	NBN	366	O60934
DEEDEDDEWSSRSQS	RAPGEF5	41	Q92565
SSGEEDDWESSADEA	PPP1R15B	536	Q5SWA1
DDWESSADEAESLKL	PPP1R15B	541	Q5SWA1
STKDSDDWADLDDLD	CILK1	411	Q9UPZ9
TSWDEDAWASKDTEA	VCL	251	P18206
KEQEAWEEATSEDSS	TP53BP1	741	Q12888
EEDMEDDTSWRSEAT	USP7	56	Q93009