Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	calcium ion binding	CAPN12 P4HTM PLA2G4C PCDHGB7 PCDHGB6 PCDHGB2 ACAN PCDHGB4 FLG2 PKDREJ LRP1B PLS1	7.58e-05	749	85	12	GO:0005509
Domain	Cadherin_tail	PCDHGB7 PCDHGB6 PCDHGB2 PCDHGB4	2.14e-05	37	83	4	PF15974
Domain	Cadherin_CBD	PCDHGB7 PCDHGB6 PCDHGB2 PCDHGB4	2.14e-05	37	83	4	IPR031904
Domain	Cadherin_C	PCDHGB7 PCDHGB6 PCDHGB2 PCDHGB4	3.57e-05	42	83	4	IPR032455
Domain	Cadherin_C_2	PCDHGB7 PCDHGB6 PCDHGB2 PCDHGB4	3.57e-05	42	83	4	PF16492
Domain	DUF1981	ARFGEF2 ARFGEF1	1.16e-04	4	83	2	PF09324
Domain	Sec7_N	ARFGEF2 ARFGEF1	1.16e-04	4	83	2	IPR032691
Domain	Sec7_N	ARFGEF2 ARFGEF1	1.16e-04	4	83	2	PF12783
Domain	DCB_dom	ARFGEF2 ARFGEF1	1.16e-04	4	83	2	IPR032629
Domain	DCB	ARFGEF2 ARFGEF1	1.16e-04	4	83	2	PF16213
Domain	Sec7_C	ARFGEF2 ARFGEF1	1.16e-04	4	83	2	IPR015403
Domain	Cadherin_2	PCDHGB7 PCDHGB6 PCDHGB2 PCDHGB4	2.00e-04	65	83	4	PF08266
Domain	Cadherin_N	PCDHGB7 PCDHGB6 PCDHGB2 PCDHGB4	2.00e-04	65	83	4	IPR013164
Domain	MHC_I_3	CD1C PROCR	2.89e-04	6	83	2	PF16497
Domain	Glyco_hydro/deAcase_b/a-brl	ST6GAL2 MAN2A1	4.04e-04	7	83	2	IPR011330
Domain	G-protein_beta_WD-40_rep	TBL1Y RRP9 MLST8 TBL1XR1	5.58e-04	85	83	4	IPR020472
Domain	LisH	TBL1Y TBL1XR1	6.88e-04	9	83	2	PF08513
Domain	WD40_repeat_CS	TBL1Y RRP9 HERC1 MLST8 TBL1XR1	8.21e-04	164	83	5	IPR019775
Domain	WD40	TBL1Y RRP9 HERC1 MLST8 TBL1XR1 SHKBP1	1.04e-03	259	83	6	PF00400
Domain	PTBI	DOK6 DOK5	1.05e-03	11	83	2	SM00310
Domain	WD40	TBL1Y RRP9 HERC1 MLST8 TBL1XR1 SHKBP1	1.24e-03	268	83	6	SM00320
Domain	IRS_PTB	DOK6 DOK5	1.25e-03	12	83	2	PS51064
Domain	WD40_repeat	TBL1Y RRP9 HERC1 MLST8 TBL1XR1 SHKBP1	1.33e-03	272	83	6	IPR001680
Domain	Cadherin_CS	PCDHGB7 PCDHGB6 PCDHGB2 PCDHGB4	1.42e-03	109	83	4	IPR020894
Domain	WD_REPEATS_1	TBL1Y RRP9 HERC1 MLST8 TBL1XR1 SHKBP1	1.49e-03	278	83	6	PS00678
Domain	WD_REPEATS_2	TBL1Y RRP9 HERC1 MLST8 TBL1XR1 SHKBP1	1.52e-03	279	83	6	PS50082
Domain	WD_REPEATS_REGION	TBL1Y RRP9 HERC1 MLST8 TBL1XR1 SHKBP1	1.52e-03	279	83	6	PS50294
Domain	CADHERIN_1	PCDHGB7 PCDHGB6 PCDHGB2 PCDHGB4	1.62e-03	113	83	4	PS00232
Domain	Cadherin	PCDHGB7 PCDHGB6 PCDHGB2 PCDHGB4	1.62e-03	113	83	4	PF00028
Domain	CADHERIN_2	PCDHGB7 PCDHGB6 PCDHGB2 PCDHGB4	1.67e-03	114	83	4	PS50268
Domain	-	PCDHGB7 PCDHGB6 PCDHGB2 PCDHGB4	1.67e-03	114	83	4	2.60.40.60
Domain	IRS_PTB	DOK6 DOK5	1.72e-03	14	83	2	IPR002404
Domain	IRS	DOK6 DOK5	1.72e-03	14	83	2	PF02174
Domain	CA	PCDHGB7 PCDHGB6 PCDHGB2 PCDHGB4	1.72e-03	115	83	4	SM00112
Domain	Cadherin-like	PCDHGB7 PCDHGB6 PCDHGB2 PCDHGB4	1.78e-03	116	83	4	IPR015919
Domain	Cadherin	PCDHGB7 PCDHGB6 PCDHGB2 PCDHGB4	1.89e-03	118	83	4	IPR002126
Domain	-	ARFGEF2 ARFGEF1	1.97e-03	15	83	2	1.10.1000.11
Domain	Sec7	ARFGEF2 ARFGEF1	1.97e-03	15	83	2	PF01369
Domain	Sec7_alpha_orthog	ARFGEF2 ARFGEF1	1.97e-03	15	83	2	IPR023394
Domain	WD40_repeat_dom	TBL1Y RRP9 HERC1 MLST8 TBL1XR1 SHKBP1	2.08e-03	297	83	6	IPR017986
Domain	Sec7	ARFGEF2 ARFGEF1	2.25e-03	16	83	2	SM00222
Domain	SEC7	ARFGEF2 ARFGEF1	2.25e-03	16	83	2	PS50190
Domain	Sec7_dom	ARFGEF2 ARFGEF1	2.25e-03	16	83	2	IPR000904
Domain	EGF_extracell	RELN TENM4 LRP1B	2.41e-03	60	83	3	IPR013111
Domain	EGF_2	RELN TENM4 LRP1B	2.41e-03	60	83	3	PF07974
Domain	Gal_mutarotase_SF_dom	MGAM MAN2A1	2.54e-03	17	83	2	IPR011013
Domain	-	TBL1Y RRP9 HERC1 MLST8 TBL1XR1 SHKBP1	3.67e-03	333	83	6	2.130.10.10
Domain	WD40/YVTN_repeat-like_dom	TBL1Y RRP9 HERC1 MLST8 TBL1XR1 SHKBP1	3.78e-03	335	83	6	IPR015943
Domain	IQ	LRRIQ1 MYO1E MYO18A	3.89e-03	71	83	3	PF00612
Domain	-	CD1C PROCR	5.05e-03	24	83	2	3.30.500.10
Domain	MHC_I-like_Ag-recog	CD1C PROCR	5.05e-03	24	83	2	IPR011161
Domain	HECT	HERC1 SMURF2	6.37e-03	27	83	2	PF00632
Pubmed	Arf guanine nucleotide-exchange factors BIG1 and BIG2 regulate nonmuscle myosin IIA activity by anchoring myosin phosphatase complex.	ARFGEF2 ARFGEF1	6.33e-06	2	88	2	23918382
Pubmed	Regulation of brefeldin A-inhibited guanine nucleotide-exchange protein 1 (BIG1) and BIG2 activity via PKA and protein phosphatase 1gamma.	ARFGEF2 ARFGEF1	6.33e-06	2	88	2	17360629
Pubmed	Identification and localization of two brefeldin A-inhibited guanine nucleotide-exchange proteins for ADP-ribosylation factors in a macromolecular complex.	ARFGEF2 ARFGEF1	6.33e-06	2	88	2	10716990
Pubmed	Membrane association of the Arabidopsis ARF exchange factor GNOM involves interaction of conserved domains.	ARFGEF2 ARFGEF1	6.33e-06	2	88	2	18203920
Pubmed	Purification and cloning of a brefeldin A-inhibited guanine nucleotide-exchange protein for ADP-ribosylation factors.	ARFGEF2 ARFGEF1	6.33e-06	2	88	2	10212200
Pubmed	Reelin Regulates Neuronal Excitability through Striatal-Enriched Protein Tyrosine Phosphatase (STEP61) and Calcium Permeable AMPARs in an NMDAR-Dependent Manner.	PTPN5 RELN	6.33e-06	2	88	2	34290083
Pubmed	Redundant roles of BIG2 and BIG1, guanine-nucleotide exchange factors for ADP-ribosylation factors in membrane traffic between the trans-Golgi network and endosomes.	ARFGEF2 ARFGEF1	6.33e-06	2	88	2	18417613
Pubmed	Genome-wide association identifies ATOH7 as a major gene determining human optic disc size.	UNC5C PBLD LRP1B	1.47e-05	19	88	3	20395239
Pubmed	Interaction of phosphodiesterase 3A with brefeldin A-inhibited guanine nucleotide-exchange proteins BIG1 and BIG2 and effect on ARF1 activity.	ARFGEF2 ARFGEF1	1.90e-05	3	88	2	19332778
Pubmed	Specific functions of BIG1 and BIG2 in endomembrane organization.	ARFGEF2 ARFGEF1	1.90e-05	3	88	2	20360857
Pubmed	AMY-1 (associate of Myc-1) localization to the trans-Golgi network through interacting with BIG2, a guanine-nucleotide exchange factor for ADP-ribosylation factors.	ARFGEF2 ARFGEF1	1.90e-05	3	88	2	16866877
Pubmed	Dok-6, a Novel p62 Dok family member, promotes Ret-mediated neurite outgrowth.	DOK6 DOK5	1.90e-05	3	88	2	15286081
Pubmed	Next generation sequencing-based mutation screening of 86 patients with idiopathic short stature.	ACAN FGFR3	1.90e-05	3	88	2	28768959
Pubmed	A C-terminal sequence in the guanine nucleotide exchange factor Sec7 mediates Golgi association and interaction with the Rsp5 ubiquitin ligase.	ARFGEF2 ARFGEF1	1.90e-05	3	88	2	18832381
Pubmed	Involvement of BIG1 and BIG2 in regulating VEGF expression and angiogenesis.	ARFGEF2 ARFGEF1	1.90e-05	3	88	2	31199673
Pubmed	Distinct functions for Arf guanine nucleotide exchange factors at the Golgi complex: GBF1 and BIGs are required for assembly and maintenance of the Golgi stack and trans-Golgi network, respectively.	ARFGEF2 ARFGEF1	1.90e-05	3	88	2	18003980
Pubmed	Enhancement of β-catenin activity by BIG1 plus BIG2 via Arf activation and cAMP signals.	ARFGEF2 ARFGEF1	1.90e-05	3	88	2	27162341
Pubmed	The Sec7 guanine nucleotide exchange factor GBF1 regulates membrane recruitment of BIG1 and BIG2 guanine nucleotide exchange factors to the trans-Golgi network (TGN).	ARFGEF2 ARFGEF1	1.90e-05	3	88	2	23386609
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	RELN P4HTM MYO1E RSPH1 CNTNAP1 ARFGEF2 HLCS ZNF83 MLST8 BECN1 LRP1B COPS5 SMURF2	2.06e-05	1285	88	13	35914814
Pubmed	Comparative DNA sequence analysis of mouse and human protocadherin gene clusters.	PCDHGB7 PCDHGB6 PCDHGB2 PCDHGB4	2.75e-05	68	88	4	11230163
Pubmed	A striking organization of a large family of human neural cadherin-like cell adhesion genes.	PCDHGB7 PCDHGB6 PCDHGB2 PCDHGB4	3.45e-05	72	88	4	10380929
Pubmed	Human NB-2 of the contactin subgroup molecules: chromosomal localization of the gene (CNTN5) and distinct expression pattern from other subgroup members.	ARFGEF2 ARFGEF1	3.79e-05	4	88	2	11013081
Pubmed	Interaction of FK506-binding protein 13 with brefeldin A-inhibited guanine nucleotide-exchange protein 1 (BIG1): effects of FK506.	ARFGEF2 ARFGEF1	3.79e-05	4	88	2	12606707
Pubmed	Strain distribution pattern in AXB and BXA recombinant inbred strains for loci on murine chromosomes 10, 13, 17, and 18.	PDE6A CSF1R	3.79e-05	4	88	2	8094988
Pubmed	Protein kinase A-anchoring (AKAP) domains in brefeldin A-inhibited guanine nucleotide-exchange protein 2 (BIG2).	ARFGEF2 ARFGEF1	3.79e-05	4	88	2	12571360
Pubmed	Effects of brefeldin A-inhibited guanine nucleotide-exchange (BIG) 1 and KANK1 proteins on cell polarity and directed migration during wound healing.	ARFGEF2 ARFGEF1	3.79e-05	4	88	2	22084092
Pubmed	Holocarboxylase synthetase acts as a biotin-independent transcriptional repressor interacting with HDAC1, HDAC2 and HDAC7.	HLCS HDAC7	3.79e-05	4	88	2	24239178
Pubmed	Cadherin superfamily genes: functions, genomic organization, and neurologic diversity.	PCDHGB7 PCDHGB6 PCDHGB2 PCDHGB4	3.85e-05	74	88	4	10817752
Pubmed	Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members.	PCDHGB7 PCDHGB6 PCDHGB2 PCDHGB4	4.50e-05	77	88	4	10835267
Pubmed	Large exons encoding multiple ectodomains are a characteristic feature of protocadherin genes.	PCDHGB7 PCDHGB6 PCDHGB2 PCDHGB4	5.23e-05	80	88	4	10716726
Pubmed	Hepatic deficiency in transcriptional cofactor TBL1 promotes liver steatosis and hypertriglyceridemia.	TBL1Y TBL1XR1	6.30e-05	5	88	2	21459324
Pubmed	Expression pattern and neurotrophic role of the c-fms proto-oncogene M-CSF receptor in rodent Purkinje cells.	RELN CSF1R	6.30e-05	5	88	2	9852586
Pubmed	Structure of the MeCP2-TBLR1 complex reveals a molecular basis for Rett syndrome and related disorders.	TBL1Y TBL1XR1	9.43e-05	6	88	2	28348241
Pubmed	Dissection of the cellular and molecular events that position cerebellar Purkinje cells: a study of the math1 null-mutant mouse.	RELN UNC5C	9.43e-05	6	88	2	12223565
Pubmed	Aggrecan is required for growth plate cytoarchitecture and differentiation.	ACAN FGFR3	1.32e-04	7	88	2	25446537
Pubmed	TFEB-dependent induction of thermogenesis by the hepatocyte SLC2A inhibitor trehalose.	BECN1 EPG5	1.32e-04	7	88	2	29996716
Pubmed	Zbtb7c is a molecular 'off' and 'on' switch of Mmp gene transcription.	TBL1Y TBL1XR1	1.32e-04	7	88	2	27646874
Pubmed	The nuclear receptor corepressor deacetylase activating domain is essential for repression by thyroid hormone receptor.	TBL1Y TBL1XR1	1.32e-04	7	88	2	15695367
Pubmed	Rescue of ataxia and preplate splitting by ectopic expression of Reelin in reeler mice.	RELN ACAN	1.75e-04	8	88	2	11856531
Pubmed	Rett syndrome mutations abolish the interaction of MeCP2 with the NCoR/SMRT co-repressor.	TBL1Y TBL1XR1	1.75e-04	8	88	2	23770565
Pubmed	A SUMOylation-dependent pathway mediates transrepression of inflammatory response genes by PPAR-gamma.	TBL1Y TBL1XR1	1.75e-04	8	88	2	16127449
Pubmed	A new role for the architecture of microvillar actin bundles in apical retention of membrane proteins.	MYO1E MYO18A PLS1	2.06e-04	45	88	3	22114352
Pubmed	The integral function of the endocytic recycling compartment is regulated by RFFL-mediated ubiquitylation of Rab11 effectors.	MYO1E ARFGEF2 RAB11FIP5	2.20e-04	46	88	3	30659120
Pubmed	Perlecan is essential for cartilage and cephalic development.	ACAN FGFR3	2.25e-04	9	88	2	10545953
Pubmed	Radial glia regulate Cajal-Retzius cell positioning in the early embryonic cerebral cortex.	RELN ACAN	2.25e-04	9	88	2	21185282
Pubmed	Molecular mechanisms governing Pcdh-gamma gene expression: evidence for a multiple promoter and cis-alternative splicing model.	PCDHGB2 PCDHGB4	2.25e-04	9	88	2	12154121
Pubmed	A conserved acetylation switch enables pharmacological control of tubby-like protein stability.	FN3KRP TONSL RAB11FIP5 TBL1XR1 COPS5	2.63e-04	223	88	5	33187986
Pubmed	Maintenance of chondroitin sulfation balance by chondroitin-4-sulfotransferase 1 is required for chondrocyte development and growth factor signaling during cartilage morphogenesis.	ACAN FGFR3	2.81e-04	10	88	2	16079159
Pubmed	A corepressor/coactivator exchange complex required for transcriptional activation by nuclear receptors and other regulated transcription factors.	TBL1Y TBL1XR1	2.81e-04	10	88	2	14980219
Pubmed	Cell array-based intracellular localization screening reveals novel functional features of human chromosome 21 proteins.	RSPH1 HLCS PDXK	3.16e-04	52	88	3	16780588
Pubmed	ApoER2 Controls Not Only Neuronal Migration in the Intermediate Zone But Also Termination of Migration in the Developing Cerebral Cortex.	RELN ACAN	3.43e-04	11	88	2	27909010
Pubmed	Clustered gamma-protocadherins regulate cortical interneuron programmed cell death.	RELN PCDHGB2 PCDHGB4	4.15e-04	57	88	3	32633719
Pubmed	CTCF Governs the Identity and Migration of MGE-Derived Cortical Interneurons.	RELN PCDHGB2 PCDHGB4	4.37e-04	58	88	3	30377227
Pubmed	A point mutation in Fgf9 impedes joint interzone formation leading to multiple synostoses syndrome.	ACAN FGFR3	4.85e-04	13	88	2	28169396
Pubmed	Control of astrocyte progenitor specification, migration and maturation by Nkx6.1 homeodomain transcription factor.	RELN FGFR3	4.85e-04	13	88	2	25285789
Pubmed	Xylosyltransferase I mediates the synthesis of proteoglycans with long glycosaminoglycan chains and controls chondrocyte hypertrophy and collagen fibers organization of in the growth plate.	ACAN FGFR3	4.85e-04	13	88	2	37296099
Pubmed	A multipoint genetic linkage map of mouse chromosome 18.	PDE6A CSF1R	5.65e-04	14	88	2	1354640
Pubmed	Identification of novel candidate genes for treatment response to risperidone and susceptibility for schizophrenia: integrated analysis among pharmacogenomics, mouse expression, and genetic case-control association approaches.	ST6GAL2 UNC5C	5.65e-04	14	88	2	19850283
Pubmed	Genetic dissection of plexin signaling in vivo.	RELN ACAN	6.51e-04	15	88	2	24469813
Pubmed	Maturation of postnatally generated olfactory bulb granule cells depends on functional γ-protocadherin expression.	PCDHGB2 PCDHGB4	6.51e-04	15	88	2	23515096
Pubmed	Sox5 and Sox6 are needed to develop and maintain source, columnar, and hypertrophic chondrocytes in the cartilage growth plate.	ACAN FGFR3	6.51e-04	15	88	2	14993235
Pubmed	Hem-1 complexes are essential for Rac activation, actin polymerization, and myosin regulation during neutrophil chemotaxis.	ARFGEF1 BECN1	6.51e-04	15	88	2	16417406
Pubmed	MOR is not enough: identification of novel mu-opioid receptor interacting proteins using traditional and modified membrane yeast two-hybrid screens.	DOK5 COPS5	6.51e-04	15	88	2	23840749
Pubmed	Synergistic drug combinations for cancer identified in a CRISPR screen for pairwise genetic interactions.	CSF1R MAN2A1 PLA2G4C FGFR3 TBL1XR1	6.95e-04	276	88	5	28319085
Pubmed	Multiple nonglycemic genomic loci are newly associated with blood level of glycated hemoglobin in East Asians.	FN3KRP FADS2	8.40e-04	17	88	2	24647736
Pubmed	Identification of novel SHOX target genes in the developing limb using a transgenic mouse model.	ACAN FGFR3	8.40e-04	17	88	2	24887312
Pubmed	ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.	P4HTM MAN2A1 LRP10 PROCR CNTNAP1 ARFGEF2 ARFGEF1 FADS2 CTSA LRP1B	9.14e-04	1201	88	10	35696571
Pubmed	A crucial role for Arf6 in the response of commissural axons to Slit.	ARFGEF2 ARFGEF1	1.05e-03	19	88	2	30674481
Pubmed	Hepatitis B Virus HBx Protein Mediates the Degradation of Host Restriction Factors through the Cullin 4 DDB1 E3 Ubiquitin Ligase Complex.	PDE6A PBLD FLG2 CNOT1 PLS1	1.07e-03	304	88	5	32235678
Pubmed	Global landscape of HIV-human protein complexes.	CNTNAP1 ARFGEF2 ARFGEF1 TBL1XR1 COPS5 PLS1	1.09e-03	457	88	6	22190034
Pubmed	A protein interaction landscape of breast cancer.	RRP9 MYO18A CTSA TBL1XR1 COPS5 FAM83B FTSJ3	1.15e-03	634	88	7	34591612
Pubmed	The transcription factors L-Sox5 and Sox6 are essential for cartilage formation.	ACAN FGFR3	1.17e-03	20	88	2	11702786
Pubmed	The transcription factor Foxg1 regulates the competence of telencephalic cells to adopt subpallial fates in mice.	RELN FGFR3	1.29e-03	21	88	2	20081193
Pubmed	Isolation of cDNA clones for 42 different Krüppel-related zinc finger proteins expressed in the human monoblast cell line U-937.	ZNF283 ZNF83	1.29e-03	21	88	2	7865130
Pubmed	Variation in genes of the epidermal differentiation complex in German atopic dermatitis patients.	PGLYRP3 FLG2	1.29e-03	21	88	2	19601998
Pubmed	Dynamic FoxG1 expression coordinates the integration of multipolar pyramidal neuron precursors into the cortical plate.	RELN UNC5C	1.41e-03	22	88	2	22726835
Pubmed	Cartilage-specific ablation of site-1 protease in mice results in the endoplasmic reticulum entrapment of type IIb procollagen and down-regulation of cholesterol and lipid homeostasis.	ACAN FADS2	1.41e-03	22	88	2	25147951
Pubmed	CUEDC2, a novel interacting partner of the SOCS1 protein, plays important roles in the leukaemogenesis of acute myeloid leukaemia.	CSF1R FGFR3 LRRC41	1.42e-03	87	88	3	29991678
Pubmed	Cartilage-specific overexpression of ERRγ results in Chondrodysplasia and reduced chondrocyte proliferation.	ACAN FGFR3	1.55e-03	23	88	2	24349082
Pubmed	LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy.	CNTNAP1 MYO18A ARFGEF2 CNOT1	1.76e-03	202	88	4	33005030
Pubmed	C5orf51 is a component of the MON1-CCZ1 complex and controls RAB7A localization and stability during mitophagy.	ARFGEF2 ARFGEF1 FADS2 RAB11FIP5 SLC12A7 FAM83B	1.79e-03	504	88	6	34432599
Pubmed	FGF15 promotes neurogenesis and opposes FGF8 function during neocortical development.	RELN FGFR3	1.83e-03	25	88	2	18625063
Pubmed	Age- and stage-specific regulation patterns in the hematopoietic stem cell hierarchy.	CSF1R FGFR3	1.83e-03	25	88	2	11698278
Pubmed	Klf4 glutamylation is required for cell reprogramming and early embryonic development in mice.	TTLL1 AGBL1	1.83e-03	25	88	2	29593216
Pubmed	Developmental abnormalities in cortical GABAergic system in mice lacking mGlu3 metabotropic glutamate receptors.	RELN ACAN	1.83e-03	25	88	2	31665922
Pubmed	System-Wide Modulation of HECT E3 Ligases with Selective Ubiquitin Variant Probes.	HERC1 SMURF2	1.98e-03	26	88	2	26949039
Pubmed	BMP canonical Smad signaling through Smad1 and Smad5 is required for endochondral bone formation.	ACAN FGFR3	2.29e-03	28	88	2	19224984
Pubmed	Interaction with protocadherin-gamma regulates the cell surface expression of protocadherin-alpha.	PCDHGB2 PCDHGB4	2.29e-03	28	88	2	15347688
Pubmed	NPAS1 represses the generation of specific subtypes of cortical interneurons.	RELN FGFR3	2.46e-03	29	88	2	25467980
Cytoband	5q31	PCDHGB7 PCDHGB6 PCDHGB2 PCDHGB4	7.41e-05	115	88	4	5q31
GeneFamily	Clustered protocadherins	PCDHGB7 PCDHGB6 PCDHGB2 PCDHGB4	6.00e-05	64	60	4	20
GeneFamily	WD repeat domain containing	TBL1Y RRP9 HERC1 MLST8 TBL1XR1 SHKBP1	2.27e-04	262	60	6	362
GeneFamily	Low density lipoprotein receptors	LRP10 LRP1B	8.25e-04	13	60	2	634
GeneFamily	Blood group antigens\|CD molecules\|I-set domain containing\|Immunoglobulin like domain containing	CD101 UNC5C IGSF9B FGFR3	2.00e-03	161	60	4	593
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Macula_Densa_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	DOK5 ST6GAL2 FLG2 LRP1B FAM83B	1.66e-05	162	87	5	373513f9d0e5007b2e10a8b78d4909dcce9e3b62
ToppCell	facs-Pancreas-Exocrine-18m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PCDHGB4 HLCS MLST8 FBXO27 PKDREJ	1.71e-05	163	87	5	953a7db7e90a913e81002d2141fbbd5f1fdf2197
ToppCell	droplet-Thymus-nan-24m-Lymphocytic-DN_to_DP_transition,_dividing_(more_DN)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CAPN12 P4HTM TONSL ARFGEF2 FADS2	1.97e-05	168	87	5	b9db0b1e4fe54a1fe79530d15d206155a1bfac39
ToppCell	PBMC-Severe-Myeloid-cDC-cDC-cDC_12\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	CD1C CSF1R MYO1E FADS2 LRP1B	2.27e-05	173	87	5	a55f310c533432e9e26e400026a5b47245152976
ToppCell	PBMC-Severe-Myeloid-cDC-cDC-cDC_12\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	CD1C CSF1R MYO1E FADS2 LRP1B	2.27e-05	173	87	5	9c7386bf0a899882c733f0b4921a96afde032a7d
ToppCell	LA-11._Adipocyte\|World / Chamber and Cluster_Paper	LVRN TENM4 TBL1Y LRP1B PDXK	2.97e-05	183	87	5	b177be283e1553fb1f69a346f1ba79ad00297fa2
ToppCell	LA-11._Adipocyte\|LA / Chamber and Cluster_Paper	LVRN TENM4 TBL1Y LRP1B PDXK	2.97e-05	183	87	5	3f9011976782fa8aa95cdd6f00f07a91094d411b
ToppCell	droplet-Heart-HEART-1m-Neuronal-nan\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DOK5 RELN PCDHGB6 FADS2 PLS1	3.21e-05	186	87	5	fddc6b93f98b10aaf8d4ebc142b46d8213f3129d
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-OPC-OPC-D\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	ST6GAL2 PCDHGB7 PCDHGB2 RHBG PCDHGB4	3.30e-05	187	87	5	6c43669e19b5b54d72d1f5d876184fee53c05f0b
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	LRRIQ1 MYO1E ZNF83 LRP1B FAM83B	3.30e-05	187	87	5	87b3d0478693d4c54ff06b74e5903036b9c1ee6a
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	LRRIQ1 MYO1E ZNF83 LRP1B FAM83B	3.30e-05	187	87	5	42a1267bfc27b4460b8409ada580a87c4385841c
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	LRRIQ1 MYO1E ZNF83 LRP1B FAM83B	3.30e-05	187	87	5	64afdea159f5e67a1e5cea35ce898aae6e80aea5
ToppCell	Tracheal-NucSeq-Stromal-Chondrocytic\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	RELN ACAN UNC5C FGFR3 LRP1B	4.54e-05	200	87	5	b5a54b9baf79aea01f76a161f0a39bbe87eb4945
ToppCell	Tracheal-NucSeq-Stromal-Chondrocytic-Chondrocyte\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	RELN ACAN UNC5C FGFR3 LRP1B	4.54e-05	200	87	5	f5bd0b30e478dac09f68c46b0781f5f2e7e3c693
ToppCell	Tracheal-10x3prime_v2-Endothelial-Endothelia_lymphatic\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	RELN PROCR RAB11FIP5 EXOC3L1 FITM1	4.54e-05	200	87	5	b515b2ab0c3f5928dd67f2f227fc932451c272bb
ToppCell	Tracheal-10x3prime_v2-Endothelial-Endothelia_lymphatic-Endothelia_Lymphatic\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	RELN PROCR RAB11FIP5 EXOC3L1 FITM1	4.54e-05	200	87	5	35f6c7f2469d12748c27f2a5d4a161ef839b4a07
Disease	mental development measurement	PCDHGB6 PCDHGB2 PCDHGB4 TBL1XR1	7.75e-07	25	85	4	EFO_0008230
Disease	sensory system disease (implicated_via_orthology)	TBL1Y TBL1XR1	2.46e-05	3	85	2	DOID:0050155 (implicated_via_orthology)
Disease	childhood trauma measurement, alcohol consumption measurement	PCDHGB7 PCDHGB6 PCDHGB2 PCDHGB4	5.38e-05	71	85	4	EFO_0007878, EFO_0007979
Disease	achondroplasia (implicated_via_orthology)	ACAN FGFR3	1.22e-04	6	85	2	DOID:4480 (implicated_via_orthology)
Disease	degenerative disc disease (biomarker_via_orthology)	ACAN BECN1	4.44e-04	11	85	2	DOID:90 (biomarker_via_orthology)
Disease	progression free survival, urinary bladder cancer	DOK6 TENM4	5.31e-04	12	85	2	EFO_0004920, MONDO_0001187
Disease	bitter alcoholic beverage consumption measurement	MGAM RELN IGSF9B AGBL1	6.02e-04	133	85	4	EFO_0010092
Disease	N-acetylglutamine measurement	RRP9 RAB11FIP5	6.27e-04	13	85	2	EFO_0800017
Disease	mean platelet volume	PCDHGB7 MYO1E PCDHGB6 PCDHGB2 ANKDD1A PCDHGB4 FADS2 SLC12A7 HDAC7 SHKBP1	6.98e-04	1020	85	10	EFO_0004584
Disease	level of Phosphatidylethanolamine (18:1_18:1) in blood serum	MYO1E FADS2	7.30e-04	14	85	2	OBA_2045142
Disease	Neoplasm of uncertain or unknown behavior of bladder	FGFR3 TBL1XR1	8.40e-04	15	85	2	C0496930
Disease	Benign neoplasm of bladder	FGFR3 TBL1XR1	8.40e-04	15	85	2	C0154017
Disease	Carcinoma in situ of bladder	FGFR3 TBL1XR1	8.40e-04	15	85	2	C0154091
Disease	lipid metabolism disorder (implicated_via_orthology)	FADS2 FITM1	8.40e-04	15	85	2	DOID:3146 (implicated_via_orthology)
Disease	Malignant neoplasm of breast	CSF1R PCDHGB6 RRP9 ARFGEF2 HLCS DIP2C EXOC3L1 PKDREJ HDAC7 EPG5	1.03e-03	1074	85	10	C0006142
Disease	Manic Disorder	RELN TENM4 FADS2	1.14e-03	71	85	3	C0024713
Disease	phosphatidylcholine 36:4 measurement	UGT2B4 FADS2	1.22e-03	18	85	2	EFO_0010382
Disease	Carcinoma of bladder	FGFR3 TBL1XR1	1.22e-03	18	85	2	C0699885
Disease	Phenyllactate (PLA) measurement	ST6GAL2 CNOT1	1.36e-03	19	85	2	EFO_0021662
Disease	level of Phosphatidylethanolamine (18:0_20:4) in blood serum	MYO1E FADS2	1.36e-03	19	85	2	OBA_2045140
Disease	Manic	RELN TENM4 FADS2	1.50e-03	78	85	3	C0338831
Disease	platelet component distribution width	CAPN12 DOK6 ANKDD1A FADS2 TTLL1 HERC1 SLC12A7 HDAC7	1.51e-03	755	85	8	EFO_0007984
Disease	sucrose liking measurement	RELN PCDHGB4	1.51e-03	20	85	2	EFO_0010157
Disease	Depression, Bipolar	RELN TENM4 FADS2	1.56e-03	79	85	3	C0005587
Disease	osteoarthritis (biomarker_via_orthology)	NAPEPLD ACAN	1.66e-03	21	85	2	DOID:8398 (biomarker_via_orthology)
Disease	liver cirrhosis (is_marker_for)	RELN CSF1R BECN1	1.73e-03	82	85	3	DOID:5082 (is_marker_for)
Disease	Sarcosine measurement	PCDHGB2 PCDHGB4	1.99e-03	23	85	2	EFO_0021668
Disease	nighttime rest measurement	MYO18A HLCS	2.17e-03	24	85	2	EFO_0007827
Disease	level of Phosphatidylethanolamine (16:0_18:2) in blood serum	MYO1E FADS2	2.17e-03	24	85	2	OBA_2045136
Disease	platelet measurement	DOK6 ANKDD1A FADS2 SLC12A7 HDAC7	2.19e-03	315	85	5	EFO_0005036
Disease	retinitis pigmentosa (implicated_via_orthology)	PDE6A EPG5	2.75e-03	27	85	2	DOID:10584 (implicated_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
QYNVVQLWAHTLHSG	EXOC3L1	301	Q86VI1
QVGRLENAIGWYHSH	COPS5	126	Q92905
HVWYQGNASLGGHLT	PROCR	41	Q9UNN8
DHWAQYVSHNQGSGL	EPG5	656	Q9HCE0
TVSAGGVLNDQHWHY	CNTNAP1	251	P78357
FSVLHTYQDHLWRSG	EIF2D	166	P41214
TVAHTDGNYLGNSWH	ARFGEF1	1031	Q9Y6D6
TVAHTDGNYLGNSWH	ARFGEF2	976	Q9Y6D5
YVVSHEIGHQWFGNL	LVRN	411	Q6Q4G3
HCTNGVWSRSHYQVG	CASP8AP2	221	Q9UKL3
GYVTSLLGLHQDWHS	AGBL1	186	Q96MI9
LVRNSHHTWLYQGEG	P4HTM	271	Q9NXG6
GSAHAVLSSYWSQHL	PBLD	231	P30039
GAGRAQHTQWYKLHS	RAB11FIP5	136	Q9BXF6
SGYGHIWSQNATNLV	PTPN5	106	P54829
ADSGHNAWLSYHVLQ	PCDHGB6	596	Q9Y5F9
SGHNAWLSYHVLQAS	PCDHGB4	596	Q9UN71
ADSGHNAWLSYHVVQ	PCDHGB7	596	Q9Y5F8
SQAQAGWLQHDYGHL	FADS2	171	O95864
QRHGSSQVWKHGSYG	FLG2	2336	Q5D862
AWVTVNFLTGQLHGH	ENTPD5	176	O75356
SYHTVAWSNGRGFNA	LRP10	286	Q7Z4F1
PFGLSHHGNYVFWTD	LRP1B	741	Q9NZR2
HHEVNVQFSWYGTTI	MAN2A1	786	Q16706
LNHWNHFGSGYRGSS	FN3KRP	286	Q9HA64
VQHYNVHNLYGWSQT	MGAM	1476	O43451
NSTSHYNAGTWGIVQ	HERC1	4426	Q15751
NATFHIWHSGQFGTI	BECN1	271	Q14457
YWVHSGQQVHLGSAE	HLCS	666	P50747
HGKALWENGTYQHSV	FAM83B	296	Q5T0W9
ATAGYDHTVRFWQAH	MLST8	16	Q9BVC4
VNYHLTNAGWHTISN	PLS1	276	Q14651
ADSGHNAWLSYHVLQ	PCDHGB2	596	Q9Y5G2
HFLLGHSHGTNWVEY	MYO18A	926	Q92614
VGWHIQGSHTYGFND	PGLYRP3	256	Q96LB9
ITYHNWRHGFNVGQT	PDE6A	556	P16499
FTNQIHKWSHTYFGL	PEDS1	181	A5PLL7
SAYWQHITRQHSTGQ	DOK5	266	Q9P104
HDDHFGTSYQQWLSS	HAUS5	216	O94927
TYQWLHTQVGVHETT	LRRIQ1	1631	Q96JM4
HNATLATTGQLYAAW	ACAN	601	P16112
EYSTNHGLTWHLVQE	RELN	951	P78509
GSGSKHLHYWFVESQ	CTSA	56	P10619
EWGTTHNFLYKHGGI	PLA2G4C	356	Q9UP65
FQHGYAGVFHFQLWQ	CAPN12	131	Q6ZSI9
HTNYSFSPWHGFTIH	CSF1R	151	P07333
QHTHLSVTWYLTQDG	CD101	176	Q93033
VGSWHNNGFYGHYRS	C3orf84	6	H3BNL1
SLGGQDIILYWGHHF	CD1C	286	P29017
SAYWHHITRQNSVGE	DOK6	266	Q6PKX4
HQWRGYTVSSHTFLL	FITM1	176	A5D6W6
IYHFQAQGGSFWSIT	FSCN3	426	Q9NQT6
LGEIWVHSAHNASGY	DIP2C	1371	Q9Y2E4
WDVHHGNGTQQTFYQ	HDAC7	706	Q8WUI4
AGNSIGFSHHSAWLV	FGFR3	341	P22607
QFWAGHYGARVTNSS	FBXO27	261	Q8NI29
AYGIHNNSATSALWG	SLC12A7	326	Q9Y666
LIHHGAVSQVSLYSW	LRRC41	221	Q15345
SSGHSSYIIAWHQQQ	IGLV4-60	46	A0A075B6I1
FGQHEWNYSNLIHST	PKDREJ	2111	Q9NTG1
NVGASWVHDAYSQAH	FTSJ3	121	Q8IY81
GHHNWIAVAYTQFLV	SHKBP1	201	Q8TBC3
YFFAAGQPGWHSHTQ	ST6GAL2	131	Q96JF0
VTINHLYQFAGGWTL	OR56A3	196	Q8NH54
DTYTGEWFAHQRHGQ	RSPH1	111	Q8WYR4
GTLAYVSQQAWIFHG	ABCC12	541	Q96J65
VQFSNHTGYAHWKGQ	PDXK	41	O00764
HTGYAHWKGQVLNSD	PDXK	46	O00764
VHIWNTQTGALVHSY	TBL1XR1	466	Q9BZK7
EQQWTGTRSYQEHGH	ANKDD1A	446	Q495B1
NSAIILHYAWHGQGQ	CNOT1	516	A5YKK6
QVYFLHTQTGVSTWH	SMURF2	266	Q9HAU4
VPTFYHAWVQNHGAG	TAS1R1	666	Q7RTX1
LQWSTLVQGFLHSFH	RHBG	101	Q9H310
HDLTWFQYHSLDVTG	UGT2B4	481	P06133
WEAQSCQHLYTFTGH	RRP9	226	O43818
QYDTFHNGSWVHLTI	IGSF9B	121	Q9UPX0
FLANFYINGGKHWTH	STPG3	11	Q8N7X2
YNLGTIHWRAGQHSQ	TONSL	206	Q96HA7
HETGFIQYLDSGIWH	TENM4	526	Q6N022
VHIWNTQSGSLVHSY	TBL1Y	476	Q9BQ87
QHVTYSHLGGWIFSN	TBX19	236	O60806
FYHVWSGSQRNLHCT	UNC5C	766	O95185
SGHVSLFWYQQALGQ	TRBV7-8	46	A0A1B0GX51
DYNHIHGGKWTVSNL	TTLL1	251	O95922
SQNSYLAYHWRIHTG	ZNF83	411	P51522
WGYQLTRHQIFHTGE	ZNF283	386	Q8N7M2
SYSVGISALHWLQQH	TRAV41	46	A0A0B4J266
NSWNQGFIIHHYAGK	MYO1E	496	Q12965
AIHWGTFALANEHYL	NAPEPLD	341	Q6IQ20