Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	transmembrane signaling receptor activity	TBXA2R CHRNA6 F2RL3 NTRK1 MRGPRE HTR3E GPR152 OR2AG2 HTR3C S1PR2 OR2J1 GRID2 OR2J2 VN1R1 OR6K6 OR4M2B TLR10 ADORA1 ADORA2A ADORA2B OR4M2 GPR149 TLR5 MRGPRG LPAR2 OR6T1 PLXNB1 NOTCH2 PLXNB3 HCRTR2 GP1BA GP1BB TMEM63A	5.09e-10	1353	145	33	GO:0004888
GeneOntologyMolecularFunction	G protein-coupled receptor activity	TBXA2R F2RL3 MRGPRE GPR152 OR2AG2 S1PR2 OR2J1 OR2J2 VN1R1 OR6K6 OR4M2B ADORA1 ADORA2A ADORA2B OR4M2 GPR149 MRGPRG LPAR2 OR6T1 HCRTR2 GP1BA	1.68e-06	884	145	21	GO:0004930
GeneOntologyMolecularFunction	ligand-gated monoatomic ion channel activity	ANO4 CHRNA6 HCN4 HCN1 HTR3E HTR3C GRID2 ANO3 TMEM63A	1.20e-05	193	145	9	GO:0015276
GeneOntologyMolecularFunction	G protein-coupled adenosine receptor activity	ADORA1 ADORA2A ADORA2B	1.29e-05	7	145	3	GO:0001609
GeneOntologyMolecularFunction	ligand-gated channel activity	ANO4 CHRNA6 HCN4 HCN1 HTR3E HTR3C GRID2 ANO3 TMEM63A	1.41e-05	197	145	9	GO:0022834
GeneOntologyMolecularFunction	acetylgalactosaminyltransferase activity	GALNT1 B3GALNT2 GALNT13 GALNT6	1.17e-04	35	145	4	GO:0008376
GeneOntologyMolecularFunction	polypeptide N-acetylgalactosaminyltransferase activity	GALNT1 GALNT13 GALNT6	3.91e-04	20	145	3	GO:0004653
GeneOntologyMolecularFunction	thrombin-activated receptor activity	F2RL3 GP1BA	5.16e-04	5	145	2	GO:0015057
GeneOntologyMolecularFunction	serotonin-gated monoatomic cation channel activity	HTR3E HTR3C	5.16e-04	5	145	2	GO:0022850
GeneOntologyMolecularFunction	proteinase-activated receptor activity	F2RL3 GP1BA	5.16e-04	5	145	2	GO:0001648
GeneOntologyMolecularFunction	ligand-gated monoatomic cation channel activity	CHRNA6 HCN4 HCN1 HTR3E HTR3C TMEM63A	5.58e-04	140	145	6	GO:0099094
GeneOntologyMolecularFunction	gated channel activity	ANO4 CHRNA6 HCN4 HCN1 HTR3E HTR3C GRID2 ANO3 TMEM63A	7.62e-04	334	145	9	GO:0022836
GeneOntologyMolecularFunction	serotonin receptor activity	HTR3E HTR3C	7.71e-04	6	145	2	GO:0099589
GeneOntologyMolecularFunction	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	CHRNA6 HTR3E HTR3C GRID2	7.82e-04	57	145	4	GO:1904315
GeneOntologyMolecularFunction	histone reader activity	STK38 BRD1 TP53BP1	8.63e-04	26	145	3	GO:0140566
GeneOntologyMolecularFunction	UDP-glycosyltransferase activity	GALNT1 B3GALNT2 GALNT13 PIGQ MFNG GALNT6	8.89e-04	153	145	6	GO:0008194
GeneOntologyMolecularFunction	neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential	CHRNA6 HTR3E HTR3C GRID2	9.49e-04	60	145	4	GO:0099529
GeneOntologyMolecularFunction	transmitter-gated channel activity	CHRNA6 HTR3E HTR3C GRID2	1.28e-03	65	145	4	GO:0022835
GeneOntologyMolecularFunction	transmitter-gated monoatomic ion channel activity	CHRNA6 HTR3E HTR3C GRID2	1.28e-03	65	145	4	GO:0022824
GeneOntologyBiologicalProcess	excitatory postsynaptic potential	CHRNA6 RELN HTR3E HTR3C S1PR2 GRID2 ADORA1 ADORA2A	3.88e-06	130	145	8	GO:0060079
GeneOntologyBiologicalProcess	regulation of postsynaptic membrane potential	CHRNA6 RELN HCN1 HTR3E HTR3C S1PR2 GRID2 ADORA1 ADORA2A	5.26e-06	180	145	9	GO:0060078
GeneOntologyBiologicalProcess	chemical synaptic transmission, postsynaptic	CHRNA6 RELN HTR3E HTR3C S1PR2 GRID2 ADORA1 ADORA2A	9.62e-06	147	145	8	GO:0099565
GeneOntologyBiologicalProcess	protein O-linked glycosylation via threonine	GALNT1 GALNT13 GALNT6	3.94e-05	10	145	3	GO:0018243
GeneOntologyBiologicalProcess	inhibition of non-skeletal tissue mineralization	ENPP1 ADORA1 ADORA2A	3.94e-05	10	145	3	GO:0140928
GeneOntologyBiologicalProcess	positive regulation of small GTPase mediated signal transduction	RELN F2RL3 NTRK1 LPAR2 PLXNB1 NOTCH2	4.72e-05	92	145	6	GO:0051057
GeneOntologyBiologicalProcess	postsynaptic density assembly	RELN LRFN1 GRID2 LRFN4	9.22e-05	34	145	4	GO:0097107
GeneOntologyBiologicalProcess	G protein-coupled purinergic receptor signaling pathway	ADORA1 ADORA2A ADORA2B	9.24e-05	13	145	3	GO:0035588
GeneOntologyBiologicalProcess	G protein-coupled adenosine receptor signaling pathway	ADORA1 ADORA2A ADORA2B	9.24e-05	13	145	3	GO:0001973
GeneOntologyCellularComponent	postsynaptic membrane	CHRNA6 LRFN1 HCN1 HTR3E HTR3C GRID2 ADORA1 ADORA2A LRFN4 LRFN2 FAIM2	1.33e-04	405	146	11	GO:0045211
GeneOntologyCellularComponent	HCN channel complex	HCN4 HCN1	2.88e-04	4	146	2	GO:0098855
GeneOntologyCellularComponent	glycoprotein Ib-IX-V complex	GP1BA GP1BB	4.78e-04	5	146	2	GO:1990779
GeneOntologyCellularComponent	serotonin-activated cation-selective channel complex	HTR3E HTR3C	4.78e-04	5	146	2	GO:1904602
GeneOntologyCellularComponent	serotonin receptor complex	HTR3E HTR3C	4.78e-04	5	146	2	GO:0098665
GeneOntologyCellularComponent	cell surface	IL17A LRFN1 ENPP1 HCN1 NTRK1 LYZL6 CHADL NOD2 ADORA2B LRFN4 LRFN2 MSLNL PLAUR LPAR2 LY6H NOTCH2 PLXNB3 GP1BA	7.55e-04	1111	146	18	GO:0009986
GeneOntologyCellularComponent	receptor complex	CHRNA6 NTRK1 HTR3E HTR3C GRID2 LRP1B TLR10 PLXNB1 NOTCH2 PLXNB3 GP1BA GP1BB	7.96e-04	581	146	12	GO:0043235
GeneOntologyCellularComponent	synaptic membrane	CHRNA6 LRFN1 HCN1 HTR3E HTR3C GRID2 ADORA1 ADORA2A LRFN4 LRFN2 LPAR2 FAIM2	8.20e-04	583	146	12	GO:0097060
MousePheno	abnormal blood coagulation	TBXA2R GALNT1 F2RL3 ADORA2A MFNG SVIL PRKCQ LY6H GP1BA GP1BB	1.64e-05	240	108	10	MP:0002551
MousePheno	abnormal hemostasis	TBXA2R GALNT1 F2RL3 ADORA2A MFNG SVIL PRKCQ LY6H GP1BA GP1BB	1.76e-05	242	108	10	MP:0009676
MousePheno	increased platelet aggregation	ADORA2A SVIL PRKCQ	7.07e-05	11	108	3	MP:0009586
MousePheno	increased bleeding time	TBXA2R GALNT1 F2RL3 LY6H GP1BA GP1BB	7.24e-05	91	108	6	MP:0005606
Domain	Cys-rich_flank_reg_C	LRIT2 LRFN1 NTRK1 CHADL TLR10 LRFN4 LRFN2 TLR5 LRRN2 GP1BA GP1BB	8.26e-11	90	142	11	IPR000483
Domain	LRRCT	LRIT2 LRFN1 NTRK1 CHADL TLR10 LRFN4 LRFN2 TLR5 LRRN2 GP1BA GP1BB	8.26e-11	90	142	11	SM00082
Domain	LRR_8	LRIT2 LRFN1 NTRK1 CHADL TLR10 LRFN4 LRFN2 LRRC53 TLR5 LRRN2 GP1BA	7.77e-08	171	142	11	PF13855
Domain	LRR_TYP	LRIT2 LRFN1 CHADL TLR10 LRFN4 LRFN2 LRRC53 TLR5 LRRN2 GP1BA	1.02e-06	177	142	10	SM00369
Domain	Leu-rich_rpt_typical-subtyp	LRIT2 LRFN1 CHADL TLR10 LRFN4 LRFN2 LRRC53 TLR5 LRRN2 GP1BA	1.02e-06	177	142	10	IPR003591
Domain	-	LRIT2 LRFN1 NTRK1 CHADL NOD2 TLR10 LRFN4 LRFN2 LRRC53 TLR5 LRRN2 GP1BA GP1BB	1.07e-06	321	142	13	3.80.10.10
Domain	G_PROTEIN_RECEP_F1_1	TBXA2R F2RL3 MRGPRE GPR152 OR2AG2 S1PR2 OR2J1 OR2J2 VN1R1 OR6K6 ADORA1 ADORA2A ADORA2B OR4M2 GPR149 MRGPRG LPAR2 OR6T1 HCRTR2	1.10e-06	685	142	19	PS00237
Domain	Leu-rich_rpt	LRIT2 LRFN1 NTRK1 CHADL NOD2 TLR10 LRFN4 LRFN2 LRRC53 TLR5 LRRN2 GP1BA	1.12e-06	271	142	12	IPR001611
Domain	G_PROTEIN_RECEP_F1_2	TBXA2R F2RL3 MRGPRE GPR152 OR2AG2 S1PR2 OR2J1 OR2J2 VN1R1 OR6K6 ADORA1 ADORA2A ADORA2B OR4M2 GPR149 MRGPRG LPAR2 OR6T1 HCRTR2	1.25e-06	691	142	19	PS50262
Domain	GPCR_Rhodpsn	TBXA2R F2RL3 MRGPRE GPR152 OR2AG2 S1PR2 OR2J1 OR2J2 VN1R1 OR6K6 ADORA1 ADORA2A ADORA2B OR4M2 GPR149 MRGPRG LPAR2 OR6T1 HCRTR2	1.28e-06	692	142	19	IPR000276
Domain	L_dom-like	LRIT2 LRFN1 NTRK1 CHADL NOD2 TLR10 LRFN4 LRFN2 LRRC53 TLR5 LRRN2 GP1BA GP1BB	1.36e-06	328	142	13	IPR032675
Domain	Adenosn_rcpt	ADORA1 ADORA2A ADORA2B	1.71e-06	4	142	3	IPR001634
Domain	LRR	LRIT2 LRFN1 CHADL NOD2 TLR10 LRFN2 LRRC53 TLR5 LRRN2 GP1BA	3.23e-06	201	142	10	PS51450
Domain	GPCR_Rhodpsn_7TM	TBXA2R F2RL3 MRGPRE GPR152 OR2AG2 S1PR2 OR2J2 VN1R1 OR6K6 ADORA1 ADORA2A ADORA2B OR4M2 GPR149 MRGPRG LPAR2 OR6T1 HCRTR2	3.38e-06	670	142	18	IPR017452
Domain	7tm_1	TBXA2R F2RL3 MRGPRE GPR152 OR2AG2 S1PR2 OR2J1 OR2J2 OR6K6 ADORA1 ADORA2A ADORA2B OR4M2 GPR149 MRGPRG LPAR2 OR6T1 HCRTR2	3.91e-06	677	142	18	PF00001
Domain	LRRNT	LRIT2 CHADL LRFN4 LRFN2 LRRN2 GP1BA GP1BB	9.84e-06	98	142	7	IPR000372
Domain	LRRNT	LRIT2 CHADL LRFN4 LRFN2 LRRN2 GP1BA GP1BB	9.84e-06	98	142	7	SM00013
Domain	MRGPCRFAMILY	MRGPRE GPR152 MRGPRG	6.79e-05	11	142	3	IPR026234
Domain	7TM_GPCR_Srsx	S1PR2 ADORA1 ADORA2A ADORA2B LPAR2 HCRTR2	2.15e-04	112	142	6	SM01381
Domain	Ion_trans_N	HCN4 HCN1	3.41e-04	4	142	2	IPR013621
Domain	Prot_kin_PKC_delta	PRKCD PRKCQ	3.41e-04	4	142	2	IPR014376
Domain	Ion_trans_N	HCN4 HCN1	3.41e-04	4	142	2	PF08412
Domain	PA	PRADC1 ZNRF4 RNF150	3.81e-04	19	142	3	PF02225
Domain	PA_domain	PRADC1 ZNRF4 RNF150	3.81e-04	19	142	3	IPR003137
Domain	TIR	TLR10 SIGIRR TLR5	5.18e-04	21	142	3	SM00255
Domain	TIR	TLR10 SIGIRR TLR5	5.96e-04	22	142	3	PF01582
Domain	-	TRIML1 TRIM4 KDM4C RNF212 TRIM77 ZNRF4 MAP3K1 RNF150 BRD1 TRIM47 MLPH	6.50e-04	449	142	11	3.30.40.10
Domain	-	CHRNA6 HTR3E HTR3C	6.82e-04	23	142	3	1.20.120.370
Domain	-	TLR10 SIGIRR TLR5	6.82e-04	23	142	3	3.40.50.10140
Domain	Acetylcholine_rcpt_TM	CHRNA6 HTR3E HTR3C	6.82e-04	23	142	3	IPR027361
Domain	SPRY	TRIML1 TRIM4 TRIM77 HERC1 TRIM47	7.55e-04	94	142	5	PF00622
Domain	SPRY_dom	TRIML1 TRIM4 TRIM77 HERC1 TRIM47	7.55e-04	94	142	5	IPR003877
Domain	TIR	TLR10 SIGIRR TLR5	7.75e-04	24	142	3	PS50104
Domain	Znf_RING/FYVE/PHD	TRIML1 TRIM4 KDM4C RNF212 TRIM77 ZNRF4 MAP3K1 RNF150 BRD1 TRIM47 MLPH	7.78e-04	459	142	11	IPR013083
Domain	B30.2/SPRY	TRIML1 TRIM4 TRIM77 HERC1 TRIM47	7.92e-04	95	142	5	IPR001870
Domain	B302_SPRY	TRIML1 TRIM4 TRIM77 HERC1 TRIM47	7.92e-04	95	142	5	PS50188
Domain	Ricin_B_lectin	GALNT1 GALNT13 GALNT6	8.75e-04	25	142	3	PF00652
Domain	TIR_dom	TLR10 SIGIRR TLR5	8.75e-04	25	142	3	IPR000157
Domain	Anoct_dimer	ANO4 ANO3	1.18e-03	7	142	2	PF16178
Domain	Anoct_dimer	ANO4 ANO3	1.18e-03	7	142	2	IPR032394
Domain	hEGF	MEGF10 NOTCH2 CRB2	1.23e-03	28	142	3	PF12661
Domain	RICIN	GALNT1 GALNT13 GALNT6	1.23e-03	28	142	3	SM00458
Domain	RICIN_B_LECTIN	GALNT1 GALNT13 GALNT6	1.23e-03	28	142	3	PS50231
Domain	LRR_1	LRIT2 CHADL TLR10 LRFN4 LRFN2 TLR5 LRRN2	1.45e-03	219	142	7	PF00560
Domain	Ricin_B_lectin	GALNT1 GALNT13 GALNT6	1.50e-03	30	142	3	IPR000772
Domain	Glycos_transf_2	GALNT1 GALNT13 GALNT6	1.50e-03	30	142	3	PF00535
Domain	Glyco_trans_2-like	GALNT1 GALNT13 GALNT6	1.50e-03	30	142	3	IPR001173
Domain	ZF_RING_1	TRIML1 TRIM4 RNF212 TRIM77 ZNRF4 MAP3K1 RNF150 TRIM47	1.75e-03	291	142	8	PS00518
Domain	Butyrophylin	TRIML1 TRIM4 TRIM77 TRIM47	1.99e-03	70	142	4	IPR003879
Domain	Plexin_cytopl	PLXNB1 PLXNB3	2.00e-03	9	142	2	PF08337
Domain	Plexin_cytoplasmic_RasGAP_dom	PLXNB1 PLXNB3	2.00e-03	9	142	2	IPR013548
Domain	Plexin	PLXNB1 PLXNB3	2.00e-03	9	142	2	IPR031148
Domain	ZF_RING_2	TRIML1 TRIM4 RNF212 TRIM77 ZNRF4 MAP3K1 RNF150 TRIM47	2.03e-03	298	142	8	PS50089
Domain	Znf_C3HC4_RING-type	TRIML1 TRIM4 TRIM77 ZNRF4 RNF150 TRIM47	2.04e-03	172	142	6	IPR018957
Domain	EGF	PCSK5 RELN LRP1B HABP2 MEGF10 NOTCH2 CRB2	2.16e-03	235	142	7	SM00181
Domain	RING	TRIML1 TRIM4 RNF212 TRIM77 ZNRF4 MAP3K1 RNF150 TRIM47	2.34e-03	305	142	8	SM00184
Domain	Anoctamin	ANO4 ANO3	2.48e-03	10	142	2	PF04547
Domain	Anoctamin	ANO4 ANO3	2.48e-03	10	142	2	IPR007632
Domain	Pkinase_C	STK38 PRKCD PRKCQ	2.77e-03	37	142	3	IPR017892
Domain	EGF-like_dom	PCSK5 RELN LRP1B HABP2 MEGF10 NOTCH2 CRB2	2.98e-03	249	142	7	IPR000742
Domain	Znf_RING	TRIML1 TRIM4 RNF212 TRIM77 ZNRF4 MAP3K1 RNF150 TRIM47	3.52e-03	326	142	8	IPR001841
Domain	EGF-like_CS	RELN ZNRF4 LRP1B HABP2 MEGF10 NOTCH2 CRB2	3.86e-03	261	142	7	IPR013032
Domain	Pkinase_C	STK38 PRKCD PRKCQ	3.98e-03	42	142	3	PF00433
Domain	Neurotransmitter_ion_chnl_CS	CHRNA6 HTR3E HTR3C	4.83e-03	45	142	3	IPR018000
Domain	K_chnl_volt-dep_EAG/ELK/ERG	HCN4 HCN1	4.92e-03	14	142	2	IPR003938
Domain	Neur_chan_memb	CHRNA6 HTR3E HTR3C	5.14e-03	46	142	3	PF02932
Domain	Neurotrans-gated_channel_TM	CHRNA6 HTR3E HTR3C	5.46e-03	47	142	3	IPR006029
Domain	-	CHRNA6 HTR3E HTR3C	5.46e-03	47	142	3	2.70.170.10
Domain	Neur_chan_LBD	CHRNA6 HTR3E HTR3C	5.46e-03	47	142	3	PF02931
Domain	NEUROTR_ION_CHANNEL	CHRNA6 HTR3E HTR3C	5.46e-03	47	142	3	PS00236
Domain	Neur_channel	CHRNA6 HTR3E HTR3C	5.46e-03	47	142	3	IPR006201
Domain	Neur_chan_lig-bd	CHRNA6 HTR3E HTR3C	5.46e-03	47	142	3	IPR006202
Domain	PI3/4_kinase_CS	PI4KA PRKDC	5.65e-03	15	142	2	IPR018936
Domain	cNMP-bd_CS	HCN4 HCN1	6.42e-03	16	142	2	IPR018488
Domain	-	PI4KA PRKDC	6.42e-03	16	142	2	1.10.1070.11
Domain	PI3Kc	PI4KA PRKDC	6.42e-03	16	142	2	SM00146
Domain	LU	PLAUR LY6H	6.42e-03	16	142	2	SM00134
Domain	ConA-like_dom	TRIML1 TRIM4 TRIM77 HERC1 TRIM47 CRB2	6.63e-03	219	142	6	IPR013320
Domain	zf-C3HC4	TRIML1 TRIM4 TRIM77 ZNRF4 RNF150 TRIM47	7.22e-03	223	142	6	PF00097
Pathway	KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION	TBXA2R CHRNA6 F2RL3 S1PR2 GRID2 ADORA1 ADORA2A ADORA2B LPAR2 HCRTR2	4.11e-05	272	107	10	M13380
Pathway	WP_NUCLEOTIDE_GPCRS	ADORA1 ADORA2A ADORA2B	6.71e-05	11	107	3	M39422
Pathway	WP_NUCLEOTIDE_GPCRS	ADORA1 ADORA2A ADORA2B	8.90e-05	12	107	3	MM15953
Pathway	REACTOME_NUCLEOTIDE_LIKE_PURINERGIC_RECEPTORS	ADORA1 ADORA2A ADORA2B	2.22e-04	16	107	3	MM15050
Pathway	REACTOME_NUCLEOTIDE_LIKE_PURINERGIC_RECEPTORS	ADORA1 ADORA2A ADORA2B	2.22e-04	16	107	3	M6786
Pubmed	Expression pattern of LRR and Ig domain-containing protein (LRRIG protein) in the early mouse embryo.	LRIT2 LRFN1 NTRK1 LRFN4 LRFN2 LRRN2	6.54e-09	34	148	6	18848646
Pubmed	Transitory expression of the A2b adenosine receptor during implantation chamber development.	ADORA1 ADORA2A ADORA2B	7.55e-08	3	148	3	10536053
Pubmed	Adenosine A(1) and A(2A) receptors in mouse prefrontal cortex modulate acetylcholine release and behavioral arousal.	ADORA1 ADORA2A ADORA2B	7.55e-08	3	148	3	19158311
Pubmed	Renal afferent arteriolar and tubuloglomerular feedback reactivity in mice with conditional deletions of adenosine 1 receptors.	ADORA1 ADORA2A ADORA2B	7.55e-08	3	148	3	22896040
Pubmed	Activation of A1 and A2a adenosine receptors promotes neural progenitor cell proliferation.	ADORA1 ADORA2A ADORA2B	7.55e-08	3	148	3	29476752
Pubmed	Adenosine A₂A and A₂B receptors are both required for adenosine A₁ receptor-mediated cardioprotection.	ADORA1 ADORA2A ADORA2B	7.55e-08	3	148	3	21743001
Pubmed	Adenosine receptor subtype expression and activation influence the differentiation of mesenchymal stem cells to osteoblasts and adipocytes.	ADORA1 ADORA2A ADORA2B	7.55e-08	3	148	3	21590734
Pubmed	Cloning of two adenosine receptor subtypes from mouse bone marrow-derived mast cells.	ADORA1 ADORA2A ADORA2B	7.55e-08	3	148	3	8157966
Pubmed	Adenosine binds predominantly to adenosine receptor A1 subtype in astrocytes and mediates an immunosuppressive effect.	ADORA1 ADORA2A ADORA2B	7.55e-08	3	148	3	29935155
Pubmed	Adenosine regulates bone metabolism via A1, A2A, and A2B receptors in bone marrow cells from normal humans and patients with multiple myeloma.	ADORA1 ADORA2A ADORA2B	7.55e-08	3	148	3	23682121
Pubmed	Ankylosing spondylitis monocyte-derived macrophages express increased level of A2A adenosine receptor and decreased level of ectonucleoside triphosphate diphosphohydrolase-1 (CD39), A1 and A2B adenosine receptors.	ADORA1 ADORA2A ADORA2B	3.01e-07	4	148	3	29524036
Pubmed	Systematic deletion of adenosine receptors reveals novel roles in inflammation and pyroptosis in THP-1 macrophages.	ADORA1 ADORA2A ADORA2B	3.01e-07	4	148	3	33524770
Pubmed	Adenosine signaling contributes to ethanol-induced fatty liver in mice.	ADORA1 ADORA2A ADORA2B	3.01e-07	4	148	3	19221436
Pubmed	The SALM/Lrfn family of leucine-rich repeat-containing cell adhesion molecules.	LRFN1 LRFN4 LRFN2	3.01e-07	4	148	3	21736948
Pubmed	Loss of Reelin protects mice against arterial thrombosis by impairing integrin activation and thrombus formation under high shear conditions.	RELN GP1BA GP1BB	3.01e-07	4	148	3	28943410
Pubmed	Links between insulin resistance, adenosine A2B receptors, and inflammatory markers in mice and humans.	ADORA1 ADORA2A ADORA2B	3.01e-07	4	148	3	21270276
Pubmed	Adenosine receptors interacting proteins (ARIPs): Behind the biology of adenosine signaling.	ADORA1 ADORA2A ADORA2B	3.01e-07	4	148	3	19883624
Pubmed	A2B adenosine receptor dampens hypoxia-induced vascular leak.	ADORA1 ADORA2A ADORA2B	7.50e-07	5	148	3	18056839
Pubmed	Adenosinergic regulation of the expansion and immunosuppressive activity of CD11b+Gr1+ cells.	ADORA1 ADORA2A ADORA2B	7.50e-07	5	148	3	22039302
Pubmed	Adenosine A(1), A(2a), A(2b), and A(3) receptors in hematopoiesis. 1. Expression of receptor mRNA in four mouse hematopoietic precursor cells.	ADORA1 ADORA2A ADORA2B	7.50e-07	5	148	3	19249907
Pubmed	Adenosine A(1), A(2a), A(2b), and A(3) receptors in hematopoiesis. 2. Expression of receptor mRNA in resting and lipopolysaccharide-activated mouse RAW 264.7 macrophages.	ADORA1 ADORA2A ADORA2B	7.50e-07	5	148	3	19249906
Pubmed	Adenosine activation of A(2B) receptor(s) is essential for stimulated epithelial ciliary motility and clearance.	ADORA1 ADORA2A ADORA2B	7.50e-07	5	148	3	21622845
Pubmed	Gs protein-coupled adenosine receptor signaling and lytic function of activated NK cells.	ADORA1 ADORA2A ADORA2B	7.50e-07	5	148	3	16177079
Pubmed	Selective deletion of the A1 adenosine receptor abolishes heart-rate slowing effects of intravascular adenosine in vivo.	ADORA1 ADORA2A ADORA2B	7.50e-07	5	148	3	19707555
Pubmed	Effects of targeted deletion of A1 adenosine receptors on postischemic cardiac function and expression of adenosine receptor subtypes.	ADORA1 ADORA2A ADORA2B	7.50e-07	5	148	3	16679400
Pubmed	Detrimental effects of adenosine signaling in sickle cell disease.	ADORA1 ADORA2A ADORA2B	7.50e-07	5	148	3	21170046
Pubmed	Adenosine, an endogenous distress signal, modulates tissue damage and repair.	ADORA1 ADORA2A ADORA2B	7.50e-07	5	148	3	17396131
Pubmed	The reno-vascular A2B adenosine receptor protects the kidney from ischemia.	ADORA1 ADORA2A ADORA2B	7.50e-07	5	148	3	18578565
Pubmed	Adenosine deaminase and adenosine receptor polymorphisms in aspirin-intolerant asthma.	ADORA1 ADORA2A ADORA2B	7.50e-07	5	148	3	19019667
Pubmed	A2B adenosine receptor signaling attenuates acute lung injury by enhancing alveolar fluid clearance in mice.	ADORA1 ADORA2A ADORA2B	7.50e-07	5	148	3	18787641
Pubmed	Caffeine acts via A1 adenosine receptors to disrupt embryonic cardiac function.	ADORA1 ADORA2A ADORA2B	7.50e-07	5	148	3	22164264
Pubmed	A(2B) and A(3) adenosine receptors modulate vascular endothelial growth factor and interleukin-8 expression in human melanoma cells treated with etoposide and doxorubicin.	ADORA1 ADORA2A ADORA2B	1.50e-06	6	148	3	19794965
Pubmed	Beneficial Role of Erythrocyte Adenosine A2B Receptor-Mediated AMP-Activated Protein Kinase Activation in High-Altitude Hypoxia.	ADORA1 ADORA2A ADORA2B	1.50e-06	6	148	3	27482003
Pubmed	Physiology and effects of nucleosides in mice lacking all four adenosine receptors.	ADORA1 ADORA2A ADORA2B	1.50e-06	6	148	3	30822301
Pubmed	Excess adenosine in murine penile erectile tissues contributes to priapism via A2B adenosine receptor signaling.	ADORA1 ADORA2A ADORA2B	1.50e-06	6	148	3	18340377
Pubmed	Resetting microbiota by Lactobacillus reuteri inhibits T reg deficiency-induced autoimmunity via adenosine A2A receptors.	ADORA1 ADORA2A ADORA2B	1.50e-06	6	148	3	27994068
Pubmed	Cardioprotection by ecto-5'-nucleotidase (CD73) and A2B adenosine receptors.	ADORA1 ADORA2A ADORA2B	1.50e-06	6	148	3	17353435
Pubmed	Comparative analysis of structure, expression and PSD95-binding capacity of Lrfn, a novel family of neuronal transmembrane proteins.	LRFN1 LRFN4 LRFN2	2.61e-06	7	148	3	16828986
Pubmed	Adenosine derived from ecto-nucleotidases in calcific aortic valve disease promotes mineralization through A2a adenosine receptor.	ENPP1 ADORA1 ADORA2A	2.61e-06	7	148	3	25644539
Pubmed	Adenosine receptors differentially regulate type 2 cytokine production by IL-33-activated bone marrow cells, ILC2s, and macrophages.	ADORA1 ADORA2A ADORA2B	2.61e-06	7	148	3	28982732
Pubmed	A novel family of adhesion-like molecules that interacts with the NMDA receptor.	LRFN1 LRFN4 LRFN2	2.61e-06	7	148	3	16495444
Pubmed	Erythrocytes retain hypoxic adenosine response for faster acclimatization upon re-ascent.	ADORA1 ADORA2A ADORA2B	4.16e-06	8	148	3	28169986
Pubmed	PlexinA1 signaling directs the segregation of proprioceptive sensory axons in the developing spinal cord.	LRFN1 NTRK1 LRFN2 LRRN2 PLXNB1 PLXNB3	1.14e-05	117	148	6	17145500
Pubmed	A diverse family of GPCRs expressed in specific subsets of nociceptive sensory neurons.	NTRK1 MRGPRE MRGPRG	1.22e-05	11	148	3	11551509
Pubmed	Expression profile of protein kinase C isozymes in preimplantation mouse development.	PRKCD LRRN2 PRKCQ	1.22e-05	11	148	3	16183862
Pubmed	Adenosine A1 and A2A receptors differently control synaptic plasticity in the mouse dorsal and ventral hippocampus.	ADORA1 ADORA2A	1.80e-05	2	148	2	31274188
Pubmed	5-HT3 receptor influences the washing phenotype and visual organization in obsessive-compulsive disorder supporting 5-HT3 receptor antagonists as novel treatment option.	HTR3E HTR3C	1.80e-05	2	148	2	23928294
Pubmed	Presynaptic control of striatal glutamatergic neurotransmission by adenosine A1-A2A receptor heteromers.	ADORA1 ADORA2A	1.80e-05	2	148	2	16481441
Pubmed	Protein kinase Cdelta regulates antigen receptor-induced lytic granule polarization in mouse CD8+ CTL.	PRKCD PRKCQ	1.80e-05	2	148	2	17548619
Pubmed	Functional interplay between adenosine A2A receptor and NMDA preconditioning in fear memory and glutamate uptake in the mice hippocampus.	ADORA1 ADORA2A	1.80e-05	2	148	2	33691195
Pubmed	The alpha and beta chains of human platelet glycoprotein Ib are both transmembrane proteins containing a leucine-rich amino acid sequence.	GP1BA GP1BB	1.80e-05	2	148	2	3353370
Pubmed	Adenosine attenuates oxidant injury in human proximal tubular cells via A(1) and A(2a) adenosine receptors.	ADORA1 ADORA2A	1.80e-05	2	148	2	11934694
Pubmed	Molecular dynamics simulations reveal insights into key structural elements of adenosine receptors.	ADORA2A ADORA2B	1.80e-05	2	148	2	21480628
Pubmed	A1 and A2A adenosine receptors play a protective role to reduce prevalence of autoimmunity following tissue damage.	ADORA1 ADORA2A	1.80e-05	2	148	2	33894002
Pubmed	Genetic basis of apnoea of prematurity and caffeine treatment response: role of adenosine receptor polymorphisms: genetic basis of apnoea of prematurity.	ADORA1 ADORA2A	1.80e-05	2	148	2	22462821
Pubmed	Association of adenosine receptor gene polymorphisms and in vivo adenosine A1 receptor binding in the human brain.	ADORA1 ADORA2A	1.80e-05	2	148	2	24943643
Pubmed	Adenosine A1 and A2A Receptors in the Brain: Current Research and Their Role in Neurodegeneration.	ADORA1 ADORA2A	1.80e-05	2	148	2	28441750
Pubmed	Association of polymorphous light eruption with NOD-2 and TLR-5 gene polymorphisms.	NOD2 TLR5	1.80e-05	2	148	2	35748133
Pubmed	Modulation of murine dendritic cell function by adenine nucleotides and adenosine: involvement of the A(2B) receptor.	ADORA2A ADORA2B	1.80e-05	2	148	2	18465770
Pubmed	Association of Toll-like receptor 10 and susceptibility to Crohn's disease independent of NOD2.	NOD2 TLR10	1.80e-05	2	148	2	21716313
Pubmed	Peripheral N- and C-terminal domains determine deactivation kinetics of HCN channels.	HCN4 HCN1	1.80e-05	2	148	2	17548059
Pubmed	Revisiting the human polypeptide GalNAc-T1 and T13 paralogs.	GALNT1 GALNT13	1.80e-05	2	148	2	27913570
Pubmed	Differential effects of adenosine A2a and A2b receptors on cardiac contractility.	ADORA2A ADORA2B	1.80e-05	2	148	2	20935155
Pubmed	Interindividual variation in anxiety response to amphetamine: possible role for adenosine A2A receptor gene variants.	ADORA1 ADORA2A	1.80e-05	2	148	2	16118787
Pubmed	Activation of adenosine A2A or A2B receptors causes hypothermia in mice.	ADORA2A ADORA2B	1.80e-05	2	148	2	29548686
Pubmed	Thrombin-induced platelet PAR4 activation: role of glycoprotein Ib and ADP.	F2RL3 GP1BA	1.80e-05	2	148	2	12871418
Pubmed	Extracellular adenosine regulates naive T cell development and peripheral maintenance.	ADORA2A ADORA2B	1.80e-05	2	148	2	24145516
Pubmed	Deletion of adenosine A₁ or A(₂A) receptors reduces L-3,4-dihydroxyphenylalanine-induced dyskinesia in a model of Parkinson's disease.	ADORA1 ADORA2A	1.80e-05	2	148	2	20828543
Pubmed	Association of ADORA1 rs2228079 and ADORA2A rs5751876 Polymorphisms with Gilles de la Tourette Syndrome in the Polish Population.	ADORA1 ADORA2A	1.80e-05	2	148	2	26317759
Pubmed	Cutting Edge: A2B Adenosine receptor signaling provides potent protection during intestinal ischemia/reperfusion injury.	ADORA2A ADORA2B	1.80e-05	2	148	2	19299692
Pubmed	Theophylline inhibits the differentiation of human monocyte into dendritic cell potentially via adenosine receptor antagonism.	ADORA1 ADORA2A	1.80e-05	2	148	2	20085598
Pubmed	Involvement of adenosine signaling in controlling the release of ghrelin from the mouse stomach.	ADORA1 ADORA2A	1.80e-05	2	148	2	20876230
Pubmed	Downregulation of A(1) and A(2B) adenosine receptors in human trisomy 21 mesenchymal cells from first-trimester chorionic villi.	ADORA1 ADORA2B	1.80e-05	2	148	2	22867902
Pubmed	Mice heterozygous for both A1 and A(2A) adenosine receptor genes show similarities to mice given long-term caffeine.	ADORA1 ADORA2A	1.80e-05	2	148	2	19036889
Pubmed	Human monocytes respond to extracellular cAMP through A2A and A2B adenosine receptors.	ADORA2A ADORA2B	1.80e-05	2	148	2	24652540
Pubmed	Decreased thrombotic tendency in mouse models of the Bernard-Soulier syndrome.	GP1BA GP1BB	1.80e-05	2	148	2	17095718
Pubmed	Reciprocal modulation of anti-IgE induced histamine release from human mast cells by A₁ and A(2B) adenosine receptors.	ADORA1 ADORA2B	1.80e-05	2	148	2	21506953
Pubmed	Central adenosine A1 and A2A receptors mediate the antinociceptive effects of neuropeptide S in the mouse formalin test.	ADORA1 ADORA2A	1.80e-05	2	148	2	25447449
Pubmed	Metabolic hyperemia requires ATP-sensitive K+ channels and H2O2 but not adenosine in isolated mouse hearts.	ADORA2A ADORA2B	1.80e-05	2	148	2	25108010
Pubmed	ADORA2A variation and adenosine A1 receptor availability in the human brain with a focus on anxiety-related brain regions: modulation by ADORA1 variation.	ADORA1 ADORA2A	1.80e-05	2	148	2	33235193
Pubmed	Adenosine A2A receptor blocks the A 1 receptor inhibition of renal Na + transport and oxygen consumption.	ADORA1 ADORA2A	1.80e-05	2	148	2	30633335
Pubmed	Adenosine A2A receptor is involved in cell surface expression of A2B receptor.	ADORA2A ADORA2B	1.80e-05	2	148	2	20926384
Pubmed	The antidepressant-like effect of inosine in the FST is associated with both adenosine A1 and A 2A receptors.	ADORA1 ADORA2A	1.80e-05	2	148	2	23613131
Pubmed	Enhanced A2A adenosine receptor-mediated increase in coronary flow in type I diabetic mice.	ADORA2A ADORA2B	1.80e-05	2	148	2	26654777
Pubmed	Role of the intracellular domains of GPIb in controlling the adhesive properties of the platelet GPIb/V/IX complex.	GP1BA GP1BB	1.80e-05	2	148	2	12522011
Pubmed	Thrombin-induced reactive oxygen species generation in platelets: A novel role for protease-activated receptor 4 and GPIbα.	F2RL3 GP1BA	1.80e-05	2	148	2	26569550
Pubmed	Comparative Study of Receptor-, Receptor State-, and Membrane-Dependent Cholesterol Binding Sites in A2A and A1 Adenosine Receptors Using Coarse-Grained Molecular Dynamics Simulations.	ADORA1 ADORA2A	1.80e-05	2	148	2	36637988
Pubmed	Inactivation of DNA-dependent protein kinase by protein kinase Cdelta: implications for apoptosis.	PRKCD PRKDC	1.80e-05	2	148	2	9774685
Pubmed	The role of adenosine signaling in sickle cell therapeutics.	ADORA2A ADORA2B	1.80e-05	2	148	2	24589267
Pubmed	Adenosine receptor-mediated cardioprotection: are all 4 subtypes required or redundant?	ADORA2A ADORA2B	1.80e-05	2	148	2	21335481
Pubmed	Down-regulation of adenosine A1 and A2A receptors in peripheral cells from idiopathic normal-pressure hydrocephalus patients.	ADORA1 ADORA2A	1.80e-05	2	148	2	26810542
Pubmed	Association between A2a receptor gene polymorphisms and caffeine-induced anxiety.	ADORA1 ADORA2A	1.80e-05	2	148	2	12825092
Pubmed	Biological, clinical features and modelling of heterozygous variants of glycoprotein Ib platelet subunit alpha (GP1BA) and glycoprotein Ib platelet subunit beta (GP1BB) genes responsible for constitutional thrombocytopenia.	GP1BA GP1BB	1.80e-05	2	148	2	36173017
Pubmed	Adenosine primes resting stage dendritic cells before their activation.	ADORA1 ADORA2A	1.80e-05	2	148	2	19338746
Pubmed	Regulation of Salmonella flagellin-induced interleukin-8 in intestinal epithelial cells by muramyl dipeptide.	NOD2 TLR5	1.80e-05	2	148	2	23121969
Pubmed	The Membrane-Bound Form of IL-17A Promotes the Growth and Tumorigenicity of Colon Cancer Cells.	IL17A LY6H	1.80e-05	2	148	2	27378226
Pubmed	Adenosine A2B receptor antagonist suppresses differentiation to regulatory T cells without suppressing activation of T cells.	ADORA1 ADORA2B	1.80e-05	2	148	2	21557932
Pubmed	Microbial induction of CARD15 expression in intestinal epithelial cells via toll-like receptor 5 triggers an antibacterial response loop.	NOD2 TLR5	1.80e-05	2	148	2	16897777
Pubmed	Adenosine A2A and A2B receptor expression in neuroendocrine tumours: potential targets for therapy.	ADORA2A ADORA2B	1.80e-05	2	148	2	22119961
Pubmed	The association of ADORA2A and ADORA2B polymorphisms with the risk and severity of chronic heart failure: a case-control study of a northern Chinese population.	ADORA2A ADORA2B	1.80e-05	2	148	2	25629231
Cytoband	11q13.2	GPR152 TBC1D10C LRFN4 TMEM151A	1.66e-05	47	148	4	11q13.2
GeneFamily	Adenosine receptors	ADORA1 ADORA2A ADORA2B	5.42e-07	4	94	3	211
GeneFamily	Polypeptide N-acetylgalactosaminyltransferases	GALNT1 GALNT13 GALNT6	1.46e-04	20	94	3	433
GeneFamily	5-hydroxytryptamine receptors, ionotropic	HTR3E HTR3C	2.65e-04	5	94	2	172
GeneFamily	Ring finger proteins	TRIML1 TRIM4 RNF212 TRIM77 ZNRF4 RNF150 TRIM47	5.79e-04	275	94	7	58
GeneFamily	G protein-coupled receptors, Class A orphans	MRGPRE GPR152 GPR149 MRGPRG	7.28e-04	78	94	4	262
GeneFamily	Plexins	PLXNB1 PLXNB3	9.40e-04	9	94	2	683
GeneFamily	Cyclic nucleotide gated channels	HCN4 HCN1	1.17e-03	10	94	2	250
GeneFamily	CD molecules\|Toll like receptors	TLR10 TLR5	1.17e-03	10	94	2	948
GeneFamily	Anoctamins	ANO4 ANO3	1.17e-03	10	94	2	865
GeneFamily	C2 domain containing protein kinases	PRKCD PRKCQ	1.17e-03	10	94	2	835
GeneFamily	Blood group antigens\|CD molecules\|I-set domain containing\|Immunoglobulin like domain containing	LRIT2 LRFN1 LRFN4 LRFN2 LRRN2	1.53e-03	161	94	5	593
GeneFamily	Beta 3-glycosyltransferases	B3GALNT2 MFNG	6.85e-03	24	94	2	426
ToppCell	droplet-Heart-nan-3m-Neuronal-cardiac_neuron\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PIPOX PRKCQ GALNT6 MLPH MEGF10 PLXNB1 PLXNB3	2.32e-06	180	147	7	da723df348d7b8449bb1124f23fe6fa706412adb
ToppCell	droplet-Heart-nan-3m-Neuronal\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PIPOX PRKCQ GALNT6 MLPH MEGF10 PLXNB1 PLXNB3	2.32e-06	180	147	7	5b146a94708b3c3610542a4d0925f3f7a2b19185
ToppCell	droplet-Heart-nan-3m-Neuronal-cardiac_neuron\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PIPOX PRKCQ GALNT6 MLPH MEGF10 PLXNB1 PLXNB3	2.32e-06	180	147	7	50758b1e7be2e43f83c10ab106900c067e61f5f7
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-3m-Macroglial-oligodendrocyte_precursor_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	AMZ1 S1PR2 CHADL GALNT13 ADORA2B LRRN2 LY6H	3.43e-06	191	147	7	ece87127f85939e61b1048d968ed96f0e87c3a79
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-3m-Macroglial-Oligodendrocyte_progenitor_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	AMZ1 S1PR2 CHADL GALNT13 ADORA2B LRRN2 LY6H	3.43e-06	191	147	7	478e8341ee03b05501e2233e02cef5f97492c95d
ToppCell	(5)_Fibroblasts-(5)_Fibroblast-J_(Lipofibroblast)\|(5)_Fibroblasts / Lung cell shreds - cell class (v4) and cell subclass (v4)	TMEM238L ADORA1 PIM1 TMEM151A TRIM47 CRB2 GP1BA	3.80e-06	194	147	7	784b15119c91ace33d34bfb3d68c182566a3e9a8
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-3m-Macroglial\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADORA1 GALNT6 TMEM151A FAIM2 MEGF10 PLXNB3 TMEM63A	4.07e-06	196	147	7	f068ce40bf35021baf1468ae9ce30a92162eb14d
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-3m-Macroglial-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ANO4 GALNT6 TMEM151A FAIM2 MEGF10 PLXNB3 TMEM63A	4.21e-06	197	147	7	7b12f9d4ad1e84df58e86591a491c84d4f36eac5
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-3m-Macroglial-oligodendrocyte\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ANO4 GALNT6 TMEM151A FAIM2 MEGF10 PLXNB3 TMEM63A	4.35e-06	198	147	7	97ae237f955fd5fbd01d06aafe89ef9e6f777a9a
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-3m-Macroglial\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ANO4 ADORA1 PRKCQ TMEM151A FAIM2 PLXNB3 TMEM63A	4.65e-06	200	147	7	56f1f007ba8c9188a4b10e52744f1e50dc0f155a
ToppCell	wk_08-11-Hematologic-Meg-ery-Platelet\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	TBXA2R F2RL3 MYH7B ADORA2B PIM1 GP1BA	1.54e-05	160	147	6	e0591f95f3f47ffbe013ebbebf6bed8c7c344732
ToppCell	TCGA-Bile_Duct-Primary_Tumor-Cholangiocarcinoma-Intrahepatic-2\|TCGA-Bile_Duct / Sample_Type by Project: Shred V9	HCN4 VN1R1 ADORA2B TLR5 LY6H NOTCH2	2.03e-05	168	147	6	c70bf73bb800e4722cedc35bbc17ea3113d1012d
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Medullary_Thick_Ascending_Limb_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	STUM RNF212 LRP1B HPDL RNF150 PRKCQ	2.55e-05	175	147	6	e5467dacf81f1f913b1719931cf1a7331434a7e7
ToppCell	10x5'-lymph-node_spleen-Hematopoietic_Erythro-Mega\|lymph-node_spleen / Manually curated celltypes from each tissue	TBXA2R F2RL3 ADORA2B PLXNB3 GP1BA GP1BB	2.55e-05	175	147	6	5ca3369ce2c2bb88ba097260195aecd67cec1a3a
ToppCell	10x5'-lymph-node_spleen-Hematopoietic_Erythro-Mega-Megakaryocyte_early\|lymph-node_spleen / Manually curated celltypes from each tissue	TBXA2R F2RL3 ADORA2B PLXNB3 GP1BA GP1BB	2.64e-05	176	147	6	50fe3fd862dd6a6550ebb8c27f337cde468efedc
ToppCell	droplet-Liver-Npc-18m-Lymphocytic-macrophage/monocyte\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TBC1D10C ADORA2B PLA2G4B PRKDC GALNT6 NOTCH2	2.81e-05	178	147	6	09d2687e0d79f12e90af35fc1c0453d249cf2d19
ToppCell	Posterior_cortex-Macroglia-POLYDENDROCYTE-P2-Tnr\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	PMEL TLR5 PRKCQ PLXNB3 GP1BB	3.23e-05	110	147	5	b9c8014fd2820e5ea28a7e02fd24227b99e71eb3
ToppCell	Posterior_cortex-Macroglia-POLYDENDROCYTE-P2\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	PMEL TLR5 PRKCQ PLXNB3 GP1BB	3.23e-05	110	147	5	ee45592e936d32881c0f3429c21360670e5b3ce3
ToppCell	10x5'v1-week_17-19-Hematopoietic-MK-MK\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	STUM F2RL3 CHADL PLXNB3 GP1BA GP1BB	3.28e-05	183	147	6	9c66a40c355387f805dbdca4162dd05af5c1d8d4
ToppCell	3'-Parenchyma_lung-Epithelial-Neuro-endocrine/ionocytic-lung_neuroendocrine_cell-Neuroendocrine\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ANO4 HCN1 GALNT13 TMEM151A LY6H GP1BB	3.48e-05	185	147	6	b52e6adfecac93210c27c1d321a5951d54846c40
ToppCell	droplet-Marrow-nan-18m-Hematologic-hematopoietic_precursor_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	F2RL3 PRKCQ GALNT6 TRIM47 GP1BA GP1BB	3.48e-05	185	147	6	de353368f4f6a7a0a66e391d586879876fbe2734
ToppCell	3'-Parenchyma_lung-Epithelial-Neuro-endocrine/ionocytic-lung_neuroendocrine_cell-Neuroendocrine-Neuroendocrine_L.0.7.2.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ANO4 HCN1 GALNT13 TMEM151A LY6H GP1BB	3.48e-05	185	147	6	a34663974868e267495240c0d5c06e390f57b08b
ToppCell	3'-Parenchyma_lung-Epithelial-Neuro-endocrine/ionocytic-lung_neuroendocrine_cell\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ANO4 HCN1 GALNT13 TMEM151A LY6H GP1BB	3.48e-05	185	147	6	522030941687a268ec2520248df1817b57744a19
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Non-neuronal-Macroglial-Astro-Astrocyte-Astro_L1-6_FGFR3_ETNPPL\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ADORA2B KIAA1755 PRKCQ MEGF10 PLXNB1 NOTCH2	3.70e-05	187	147	6	4d2115a05ec36dd179ca1d4a525f2d4501aea557
ToppCell	Somatosensory_Cortex_(S1)-Non-neuronal-Macroglial-Oligo\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	KIAA1755 GALNT6 MEGF10 PLXNB1 PLXNB3 TMEM63A	3.81e-05	188	147	6	60242c29c7f16c94a84685d3bc4ed93a66e70152
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Non-neuronal-Macroglial\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	KIAA1755 MEGF10 PLXNB1 NOTCH2 PLXNB3 TMEM63A	4.04e-05	190	147	6	2de8e4cfeee350a9a76af749d6ce58d948c129b8
ToppCell	Somatosensory_Cortex_(S1)-Non-neuronal-Macroglial-Oligo-Oligodendrocyte-Oligo_L4-6_MOBP_COL18A1\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CHADL KIAA1755 GALNT6 MEGF10 PLXNB3 TMEM63A	4.04e-05	190	147	6	6b101359f397020a21e2bfd15851cb48e71f4502
ToppCell	15-Distal-Mesenchymal-Mesenchyme_SERPINF1-high\|Distal / Age, Tissue, Lineage and Cell class	SVIL TMEM151A LY6H FAIM2 MLPH CRB2	4.04e-05	190	147	6	b47472dc9fe6ed99c2365203a3d8a59879e74a70
ToppCell	facs-Brain_Non-Myeloid-Cortex-3m-Macroglial-oligodendrocyte_precursor_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	AMZ1 S1PR2 CHADL PMEL GALNT13 LRRN2	4.04e-05	190	147	6	9b825b2586c7b173ff27fcf2abc5860faf50984a
ToppCell	Primary_Motor_Cortex_(M1)-Non-neuronal-Macroglial-Oligo-Oligodendrocyte-Oligo_L4-6_MOBP_COL18A1\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CHADL KIAA1755 GALNT6 MEGF10 PLXNB3 TMEM63A	4.04e-05	190	147	6	396b7225c2430db3dc55a3d0db70239b71987229
ToppCell	facs-Brain_Non-Myeloid-Cortex-3m-Macroglial-Oligodendrocyte_progenitor_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	AMZ1 S1PR2 CHADL PMEL GALNT13 LRRN2	4.04e-05	190	147	6	d146af1926474328a7c822bc140c4dda66e1bbfb
ToppCell	PCW_05-06-Mesenchymal-Mesenchymal_fibroblastic-mes_mesothelial_(19)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	HCN4 GRID2 LRRN2 TMEM151A LY6H CRB2	4.16e-05	191	147	6	4c4eb61e6179d2f8fc524d2f813db9cba84f67a2
ToppCell	PCW_05-06-Mesenchymal-Mesenchymal_fibroblastic-mes_adventitial_fibro_(10)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	RELN HCN1 GRID2 LRP1B SVIL LY6H	4.16e-05	191	147	6	156b467187331ac6ca390d6ca861d9670bb7b956
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Non-neuronal\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	KIAA1755 MEGF10 PLXNB1 NOTCH2 PLXNB3 TMEM63A	4.16e-05	191	147	6	f3158cedf67e3b90aa94ea1f61c72c33aaa2d5ba
ToppCell	3'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_1-Subpleural_fibroblasts-Subpleural_fibroblasts_L.2.1.5.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ADORA1 PIM1 KIAA1755 TRIM47 FAIM2 CRB2	5.09e-05	198	147	6	c66097ae9ba0b50561083c423565665958ef0bb8
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-OPC\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	AMZ1 LRP1B GALNT13 LY6H FAIM2 PLXNB3	5.23e-05	199	147	6	333056c2abe9724efeab542c0365fcfe4eff8f18
ToppCell	facs-Brain_Non-Myeloid-Cortex-3m-Macroglial-oligodendrocyte\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ANO4 GALNT6 TMEM151A FAIM2 PLXNB3 TMEM63A	5.23e-05	199	147	6	67d8c7e5356f5d409d4f98e8338cf6c499fd7aee
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-OPC-OPC\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	AMZ1 LRP1B GALNT13 LY6H FAIM2 PLXNB3	5.23e-05	199	147	6	e60ecbb8fa7bcd3e2ce7d78f6efb2cfd1fd77698
ToppCell	Control_saline-Hematopoietic_Myeloid-Dendritic_cells-pDC\|Control_saline / Treatment groups by lineage, cell group, cell type	TMEM161A PRKCD PLAUR ST6GALNAC4 LPAR2 GALNT6	5.23e-05	199	147	6	34b95e27581bb127e0b921e9c068dc094cb86b37
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-OPC-OPC-F\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	AMZ1 GALNT13 LRFN2 LY6H FAIM2 PLXNB3	5.38e-05	200	147	6	ad777683adeb2ce45ade570386235e311fa7ea2d
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-3m-Macroglial-oligodendrocyte\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ANO4 GALNT6 TMEM151A FAIM2 PLXNB3 TMEM63A	5.38e-05	200	147	6	e5b4821fff40566c4a7dc3f74a14e27eb06b165d
ToppCell	primary_visual_cortex-Neuronal-glutamatergic_neuron-L6b-L6b_VISp_Col8a1_Rxfp1\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	PCSK5 CHRNA6 CNFN ADORA2A SVIL	7.43e-05	131	147	5	81efe8b0ca4377e557a42ddb12aecaf3f46b15bf
ToppCell	frontal_cortex-Non-neuronal-oligodendrocyte-Oligo-OPC_Pdgfra_Grm5\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	S1PR2 PMEL ADORA2B PRKCQ PLXNB3	7.99e-05	133	147	5	63d2f096ae47d9b587acc6c5fbd346e5e58842b8
ToppCell	frontal_cortex-Non-neuronal-oligodendrocyte-Oligo-Oligo_Synpr\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	SLC34A3 PRKCQ GALNT6 PLXNB3 TMEM63A	9.19e-05	137	147	5	b03f19b233c1c809f2cd2b4a7642eeaf254a6289
Drug	GR79236	TBXA2R ADORA1 ADORA2A ADORA2B	5.59e-08	7	146	4	CID000130214
Drug	zatebradine	HCN4 HCN1 ADORA1 ADORA2A ADORA2B	5.89e-08	17	146	5	CID000065637
Drug	1-allylisoguanosine	ADORA1 ADORA2A ADORA2B	2.58e-07	3	146	3	CID006438736
Drug	2-PEMA	ADORA1 ADORA2A ADORA2B	2.58e-07	3	146	3	CID003025817
Drug	beta-chloroethyltheophylline	ADORA1 ADORA2A ADORA2B	2.58e-07	3	146	3	CID000001882
Drug	Defibrotide	ADORA1 ADORA2A ADORA2B	2.58e-07	3	146	3	DB04932
Drug	BWA1433	TBXA2R ADORA1 ADORA2A ADORA2B	7.72e-07	12	146	4	CID006439089
Drug	2-H-Ado	ADORA1 ADORA2A ADORA2B	1.03e-06	4	146	3	CID000146206
Drug	CGS 21577	ADORA1 ADORA2A ADORA2B	1.03e-06	4	146	3	CID000149362
Drug	BW A533U	ADORA1 ADORA2A ADORA2B	1.03e-06	4	146	3	CID000135109
Drug	Adenosine	ADORA1 ADORA2A ADORA2B	1.03e-06	4	146	3	DB00640
Drug	1,3-diethylxanthine	ADORA1 ADORA2A ADORA2B	1.03e-06	4	146	3	CID000101420
Drug	1-propylxanthine	ADORA1 ADORA2A ADORA2B	1.03e-06	4	146	3	CID000128525
Drug	125I-azido-PAPA-APEC	ADORA1 ADORA2A ADORA2B	2.56e-06	5	146	3	CID003083135
Drug	GP683	ADORA1 ADORA2A ADORA2B	2.56e-06	5	146	3	CID005311109
Drug	SDZ WAG 994	ADORA1 ADORA2A ADORA2B	2.56e-06	5	146	3	CID000164305
Drug	cartazolate	ADORA1 ADORA2A ADORA2B	5.09e-06	6	146	3	CID000037015
Drug	FK352	ADORA1 ADORA2A ADORA2B	5.09e-06	6	146	3	CID006442241
Drug	Cp-66713	ADORA1 ADORA2A ADORA2B	5.09e-06	6	146	3	CID000124473
Drug	I-ABOPX	ADORA1 ADORA2A ADORA2B	5.09e-06	6	146	3	CID000163889
Drug	HNBTG	ADORA1 ADORA2A ADORA2B	5.09e-06	6	146	3	CID000162449
Drug	Beta,gamma Methylene Atp	ADORA1 ADORA2A ADORA2B	5.09e-06	6	146	3	CID005311019
Drug	[18f]cpfpx	ADORA1 ADORA2A ADORA2B	5.09e-06	6	146	3	CID005461879
Drug	SHA 118	ADORA1 ADORA2A ADORA2B	5.09e-06	6	146	3	CID000131433
Drug	SHA 91	ADORA1 ADORA2A ADORA2B	5.09e-06	6	146	3	CID000131450
Drug	Theophylline	ADORA1 ADORA2A ADORA2B	8.87e-06	7	146	3	DB00277
Drug	1,3-dipropyl-8-cyclopentylxanthine	ADORA1 ADORA2A ADORA2B	8.87e-06	7	146	3	ctd:C051360
Drug	KF17837S	ADORA1 ADORA2A ADORA2B	8.87e-06	7	146	3	CID000123739
Drug	tracazolate	ADORA1 ADORA2A ADORA2B	8.87e-06	7	146	3	CID000005522
Drug	MRS1706	ADORA1 ADORA2A ADORA2B	8.87e-06	7	146	3	CID005139184
Drug	NSC517192	ADORA1 ADORA2A ADORA2B	8.87e-06	7	146	3	CID000004405
Drug	2-oxopropyl	ENPP1 ADORA1 PI4KA	8.87e-06	7	146	3	CID006432319
Drug	SHA 40	ADORA1 ADORA2A ADORA2B	8.87e-06	7	146	3	CID000131432
Drug	CGS 22492	ADORA1 ADORA2A ADORA2B	8.87e-06	7	146	3	CID000130199
Drug	PAPA-APEC	ADORA1 ADORA2A ADORA2B	8.87e-06	7	146	3	CID003081715
Drug	ATP betaS	MYH7B ENPP1 NTRK1 ADORA1 ADORA2A ADORA2B PRKCD PRKCQ	1.01e-05	162	146	8	CID005311341
Drug	antipain dihydrochloride	ADORA2A ADORA2B GP1BA	1.41e-05	8	146	3	CID000002205
Drug	LS-127054	ADORA1 ADORA2A ADORA2B	1.41e-05	8	146	3	CID000153990
Drug	FK453	ADORA1 ADORA2A ADORA2B	1.41e-05	8	146	3	CID006439091
Drug	1,3-dipropyl-8-phenylxanthine	ADORA1 ADORA2A ADORA2B	1.41e-05	8	146	3	CID000128784
Drug	PD 115199	ADORA1 ADORA2A ADORA2B	1.41e-05	8	146	3	CID000122978
Drug	5H-purine	ADORA1 ADORA2A ADORA2B	1.41e-05	8	146	3	CID000407009
Drug	RS)-2-chloro-5-hydroxyphenylglycine	RELN ADORA1 ADORA2A COIL	1.56e-05	24	146	4	CID003645780
Drug	1,3-dibutylxanthine	ADORA1 ADORA2A ADORA2B	2.11e-05	9	146	3	CID000101421
Drug	doxofylline	ADORA1 ADORA2A ADORA2B	2.11e-05	9	146	3	CID000050942
Drug	DPSPX	ENPP1 ADORA1 ADORA2A ADORA2B	2.17e-05	26	146	4	CID000001330
Drug	AC1L1BSF	TBXA2R ADORA1 ADORA2A ADORA2B	2.54e-05	27	146	4	CID000001585
Drug	YT-146	ADORA1 ADORA2A ADORA2B	3.00e-05	10	146	3	CID000146207
Drug	metrifudil	ADORA1 ADORA2A ADORA2B	3.00e-05	10	146	3	CID000065710
Drug	1-isoamyl-3-isobutylxanthine	ADORA1 ADORA2A ADORA2B	3.00e-05	10	146	3	CID000152034
Drug	LY 294002; Down 200; 10uM; MCF7; HT_HG-U133A	JMJD4 RANBP6 MAP3K1 ADORA2B LRFN4 SIGIRR PLAUR PRMT7	3.72e-05	194	146	8	5587_DN
Drug	AC1NUW3D	ADORA2A ADORA2B	4.08e-05	2	146	2	CID005462119
Drug	4-cyanobenzenesulfonyl chloride	ADORA2A ADORA2B	4.08e-05	2	146	2	CID000039497
Drug	R-AHPIA	ADORA2A ADORA2B	4.08e-05	2	146	2	CID005487050
Drug	I 371	ADORA2A ADORA2B	4.08e-05	2	146	2	CID000520695
Drug	7a61 Compound	ADORA2A ADORA2B	4.08e-05	2	146	2	CID000133093
Drug	O265	ADORA1 ADORA2A	4.08e-05	2	146	2	CID000006871
Drug	6-thiotheophylline	ADORA2A ADORA2B	4.08e-05	2	146	2	CID003036595
Drug	DITC-APEC	ADORA2A ADORA2B	4.08e-05	2	146	2	CID003037834
Drug	Pol 509	ADORA2A ADORA2B	4.08e-05	2	146	2	CID000126925
Drug	5-(5-amino-3-(4-fluorophenyl)pyrazin-2-yl)-1-isopropylprydine-2(1H)-one	ADORA1 ADORA2A	4.08e-05	2	146	2	ctd:C524699
Drug	SCH442416	ADORA2A ADORA2B	4.08e-05	2	146	2	CID010668061
Drug	NSC 14304	ADORA2A ADORA2B	4.08e-05	2	146	2	CID000076104
Drug	6-amino-1,3-dimethyluracil	ADORA1 ADORA2A	4.08e-05	2	146	2	CID000081152
Drug	1,3,5-triisothiocyanatobenzene	ADORA2A ADORA2B	4.08e-05	2	146	2	CID000058712
Drug	1-ethyltheobromine	ADORA2A ADORA2B	4.08e-05	2	146	2	CID000093219
Drug	theophylline 9-beta-D-riboside	ADORA2A ADORA2B	4.08e-05	2	146	2	CID000165142
Drug	9-ethylpurine	ADORA2A ADORA2B	4.08e-05	2	146	2	CID000225353
Drug	1-Butyltheobromine	ADORA2A ADORA2B	4.08e-05	2	146	2	CID000070835
Drug	1,3-phenylene diisothiocyanate	ADORA2A ADORA2B	4.08e-05	2	146	2	CID000018404
Drug	p-hydroxyphenylisopropyladenosine	ADORA2A ADORA2B	4.08e-05	2	146	2	CID000128639
Drug	2-amino-4-phenyl-8-pyrrolidin-1-ylmethylindeno(1,2-d)pyrimidin-5-one	ADORA1 ADORA2A	4.08e-05	2	146	2	ctd:C562225
Drug	Cgs-21197	ADORA2A ADORA2B	4.08e-05	2	146	2	CID003082810
Drug	2-iodoadenosine	ADORA2A ADORA2B	4.08e-05	2	146	2	CID000169662
Drug	DITC-XAC	ADORA2A ADORA2B	4.08e-05	2	146	2	CID003082962
Drug	Cpp-adenosine	ADORA2A ADORA2B	4.08e-05	2	146	2	CID000132348
Drug	1-octyne	ADORA2A ADORA2B	4.08e-05	2	146	2	CID000012370
Drug	6-thiocaffeine	ADORA2A ADORA2B	4.08e-05	2	146	2	CID000025768
Drug	CGS 22706	ADORA2A ADORA2B	4.08e-05	2	146	2	CID000132579
Drug	FK838	ADORA1 ADORA2A ADORA2B	4.10e-05	11	146	3	CID003035594
Drug	N6-(4-aminobenzyl)adenosine-5'-N-methyluronamide	ADORA1 ADORA2A ADORA2B	4.10e-05	11	146	3	CID000001970
Drug	ADP-beta-F	ADORA1 ADORA2A ADORA2B	4.10e-05	11	146	3	CID003081964
Drug	Ado-5'-PP[S	ENPP1 ADORA1 ADORA2A ADORA2B PI4KA	4.16e-05	60	146	5	CID005310995
Drug	AC1L9NAZ	ANO4 CASP6 ADORA1 ADORA2A ADORA2B SLC10A2 ANO3 NOTCH2	4.30e-05	198	146	8	CID000449606
Drug	Tetracaone hydrochloride [136-47-0]; Down 200; 13.2uM; HL60; HG-U133A	KDM4C CASP6 SLC22A7 ADORA1 ADORA2A PIM1 ZFHX2 TMEM63A	4.45e-05	199	146	8	1739_DN
Drug	propentofylline	NTRK1 ADORA1 ADORA2A ADORA2B	5.07e-05	32	146	4	CID000004938
Drug	1,3-dipropyl-7-methylxanthine	ADORA1 ADORA2A ADORA2B	5.45e-05	12	146	3	CID000161713
Drug	N(6)-endonorbornan-2-yl-9-methyladenine	ADORA1 ADORA2A ADORA2B	5.45e-05	12	146	3	CID000126615
Drug	AC1L1BJN	ADORA1 ADORA2A ADORA2B	7.05e-05	13	146	3	CID000001467
Drug	1-methylisoguanosine	ADORA1 ADORA2A ADORA2B	7.05e-05	13	146	3	CID000126323
Drug	N6-cyclopentyl-9-methyladenine	ADORA1 ADORA2A ADORA2B	7.05e-05	13	146	3	CID000004401
Drug	2'-O-methyladenosine	ADORA1 ADORA2A ADORA2B	7.05e-05	13	146	3	CID000102213
Drug	HENECA	ADORA1 ADORA2A ADORA2B	7.05e-05	13	146	3	CID000164437
Drug	Rp-8-CPT-cAMPS	HCN1 ADORA2A ADORA2B LPAR2	7.28e-05	35	146	4	CID010413188
Drug	norethisterone oenanthate	RELN NTRK1 ADORA1 ADORA2A ADORA2B CRNKL1	7.38e-05	109	146	6	CID000019688
Drug	naphthyridine	ADORA1 ADORA2A ADORA2B	8.93e-05	14	146	3	CID000136069
Drug	selenocompounds	ADORA1 ADORA2A ADORA2B	8.93e-05	14	146	3	CID000158795
Drug	BW A1433U	ADORA1 ADORA2A ADORA2B	1.11e-04	15	146	3	CID000122071
Drug	P-NE	HCN4 ENPP1 STK38 CASP6 ADORA1 ADORA2A ADORA2B	1.12e-04	169	146	7	CID000446755
Drug	4-aminopyrrolidine-2,4-dicarboxylate	TBXA2R ADORA1 ADORA2A ADORA2B	1.12e-04	39	146	4	CID003331970
Disease	Bernard-Soulier syndrome (implicated_via_orthology)	GP1BA GP1BB	6.21e-05	3	135	2	DOID:2217 (implicated_via_orthology)
Disease	Bernard-Soulier Syndrome	GP1BA GP1BB	6.21e-05	3	135	2	C0005129
Disease	sick sinus syndrome (implicated_via_orthology)	HCN4 HCN1	6.21e-05	3	135	2	DOID:13884 (implicated_via_orthology)
Disease	Deficiency of Platelet Glycoprotein 1b	GP1BA GP1BB	6.21e-05	3	135	2	C2713537
Disease	BERNARD-SOULIER SYNDROME	GP1BA GP1BB	6.21e-05	3	135	2	231200
Disease	Bernard Soulier syndrome	GP1BA GP1BB	6.21e-05	3	135	2	cv:C0005129
Disease	intestinal disease (is_implicated_in)	NOD2 SLC10A2	6.21e-05	3	135	2	DOID:5295 (is_implicated_in)
Disease	asthma (is_implicated_in)	TBXA2R IL17A NOD2 TLR10 ADORA1 ADORA2A	8.80e-05	157	135	6	DOID:2841 (is_implicated_in)
Disease	Barber Say syndrome	GP1BA GP1BB	1.24e-04	4	135	2	C1319466
Disease	Brooke-Spiegler syndrome	GP1BA GP1BB	1.24e-04	4	135	2	C1857941
Disease	Bernard-Soulier syndrome (is_implicated_in)	GP1BA GP1BB	1.24e-04	4	135	2	DOID:2217 (is_implicated_in)
Disease	chronic obstructive pulmonary disease (biomarker_via_orthology)	IL17A PLAUR FAIM2	2.82e-04	28	135	3	DOID:3083 (biomarker_via_orthology)
Disease	Neonatal Alloimmune Thrombocytopenia	GP1BA GP1BB	3.08e-04	6	135	2	C3853779
Disease	FNAITP	GP1BA GP1BB	3.08e-04	6	135	2	C3854603
Disease	melioidosis (is_marker_for)	TLR5 PLAUR	3.08e-04	6	135	2	DOID:5052 (is_marker_for)
Disease	Glioblastoma	PIM1 SLC22A10 NOTCH2 TP53BP1	4.83e-04	79	135	4	C0017636
Disease	X-linked infantile spasms	HCN1 PIGQ	5.71e-04	8	135	2	C4552072
Disease	ribose-5-phosphate measurement, ribulose-5-phosphate measurement	GRID2 MEGF10	5.71e-04	8	135	2	EFO_0010529, EFO_0010530
Disease	Ventricular Dysfunction	ADORA1 ADORA2A	5.71e-04	8	135	2	C0242973
Disease	Giant Cell Glioblastoma	PIM1 SLC22A10 NOTCH2 TP53BP1	6.09e-04	84	135	4	C0334588
Disease	age at onset, multiple sclerosis	PCSK5 RELN	9.13e-04	10	135	2	EFO_0004847, MONDO_0005301
Disease	colitis (biomarker_via_orthology)	IL17A NTRK1 NOD2	9.44e-04	42	135	3	DOID:0060180 (biomarker_via_orthology)
Disease	Adenocarcinoma of large intestine	NTRK1 PIM1 PRKCQ PRKDC	1.01e-03	96	135	4	C1319315
Disease	Retinal Detachment	CPAMD8 PRKCQ	1.11e-03	11	135	2	C0035305
Disease	Generalized seizures	HCN1 LETM1 ADORA2A PRKCD	1.21e-03	101	135	4	C0234533
Disease	Clonic Seizures	HCN1 LETM1 ADORA2A PRKCD	1.21e-03	101	135	4	C0234535
Disease	Convulsive Seizures	HCN1 LETM1 ADORA2A PRKCD	1.21e-03	101	135	4	C0751494
Disease	Seizures, Sensory	HCN1 LETM1 ADORA2A PRKCD	1.21e-03	101	135	4	C0751496
Disease	Non-epileptic convulsion	HCN1 LETM1 ADORA2A PRKCD	1.21e-03	101	135	4	C0751056
Disease	Atonic Absence Seizures	HCN1 LETM1 ADORA2A PRKCD	1.21e-03	101	135	4	C0751123
Disease	Complex partial seizures	HCN1 LETM1 ADORA2A PRKCD	1.21e-03	101	135	4	C0149958
Disease	Single Seizure	HCN1 LETM1 ADORA2A PRKCD	1.21e-03	101	135	4	C0751110
Disease	Nonepileptic Seizures	HCN1 LETM1 ADORA2A PRKCD	1.21e-03	101	135	4	C3495874
Disease	Visual seizure	HCN1 LETM1 ADORA2A PRKCD	1.21e-03	101	135	4	C0270824
Disease	Epileptic drop attack	HCN1 LETM1 ADORA2A PRKCD	1.21e-03	101	135	4	C0270846
Disease	Vertiginous seizure	HCN1 LETM1 ADORA2A PRKCD	1.21e-03	101	135	4	C0422855
Disease	Gustatory seizure	HCN1 LETM1 ADORA2A PRKCD	1.21e-03	101	135	4	C0422854
Disease	Seizures, Somatosensory	HCN1 LETM1 ADORA2A PRKCD	1.21e-03	101	135	4	C0422850
Disease	Olfactory seizure	HCN1 LETM1 ADORA2A PRKCD	1.21e-03	101	135	4	C0422853
Disease	Seizures, Auditory	HCN1 LETM1 ADORA2A PRKCD	1.21e-03	101	135	4	C0422852
Disease	Generalized Absence Seizures	HCN1 LETM1 ADORA2A PRKCD	1.21e-03	101	135	4	C4505436
Disease	Jacksonian Seizure	HCN1 LETM1 ADORA2A PRKCD	1.21e-03	101	135	4	C0022333
Disease	Epileptic Seizures	HCN1 LETM1 ADORA2A PRKCD	1.21e-03	101	135	4	C4317109
Disease	Absence Seizures	HCN1 LETM1 ADORA2A PRKCD	1.26e-03	102	135	4	C4316903
Disease	Convulsions	HCN1 LETM1 ADORA2A PRKCD	1.26e-03	102	135	4	C4048158
Disease	Tonic Seizures	HCN1 LETM1 ADORA2A PRKCD	1.26e-03	102	135	4	C0270844
Disease	Seizures, Focal	HCN1 LETM1 ADORA2A PRKCD	1.35e-03	104	135	4	C0751495
Disease	Myoclonic Seizures	HCN1 LETM1 ADORA2A PRKCD	1.35e-03	104	135	4	C4317123
Disease	Tonic - clonic seizures	HCN1 LETM1 ADORA2A PRKCD	1.35e-03	104	135	4	C0494475
Disease	lung disease (implicated_via_orthology)	ADORA1 ADORA2A	1.57e-03	13	135	2	DOID:850 (implicated_via_orthology)
Disease	FVC change measurement, response to placebo	RELN AMZ1	1.57e-03	13	135	2	EFO_0008344, EFO_0010339
Disease	Glioblastoma Multiforme	PIM1 SLC22A10 NOTCH2 TP53BP1	1.72e-03	111	135	4	C1621958
Disease	Metastatic melanoma	STK38 PASK PRKDC	1.96e-03	54	135	3	C0278883
Disease	hyperinsulinism (biomarker_via_orthology)	PRKCD PRKCQ	2.10e-03	15	135	2	DOID:2018 (biomarker_via_orthology)
Disease	Withdrawal Symptoms	CHRNA6 ADORA1 ADORA2A	2.40e-03	58	135	3	C0087169
Disease	Drug Withdrawal Symptoms	CHRNA6 ADORA1 ADORA2A	2.40e-03	58	135	3	C0086189
Disease	Substance Withdrawal Syndrome	CHRNA6 ADORA1 ADORA2A	2.40e-03	58	135	3	C0038587
Disease	allergic rhinitis (is_marker_for)	IL17A NOD2	2.70e-03	17	135	2	DOID:4481 (is_marker_for)
Disease	Antihistamine use measurement	WDR36 RANBP6	2.70e-03	17	135	2	EFO_0009943
Disease	rhinitis	WDR36 RANBP6	2.70e-03	17	135	2	EFO_0008521
Disease	Febrile seizure (within the age range of 3 months to 6 years)	HERC1 ANO3	3.03e-03	18	135	2	HP_0002373
Disease	temporal lobe epilepsy (is_marker_for)	RELN HCN1	3.74e-03	20	135	2	DOID:3328 (is_marker_for)

Protein segments in the cluster

Peptide	Gene	Start	Entry
HAGLLRPSSCLCWPF	nan	191	Q6ZRM9
GSTCLVKHLWLLFPC	ERC2-IT1	81	O76042
IPEGQWLCRHCLQSR	BRD1	251	O95696
PWCLALFHDRFIDLR	CFAP61	1146	Q8NHU2
HELCHLLGLGNCRWL	AMZ1	261	Q400G9
WLHSLLLHCNSPGRC	HTR3E	346	A5X5Y0
SWLPLHILNCITLFC	ADORA1	246	P30542
LFALCWLPLHIINCF	ADORA2A	241	P29274
GIFALCWLPVHAVNC	ADORA2B	241	P29275
WLHSLLLHCTSPGRC	HTR3C	346	Q8WXA8
RWRLEECHPSGCLID	ANO4	631	Q32M45
RWRLEECHPSGCLID	ANO3	676	Q9BYT9
VVPHHCLGCIWSRRD	RGL1	251	Q9NZL6
CCGAILFPVVWSIRH	GPR107	411	Q5VW38
LHSLEPWDRLVTRCC	SLC34A3	556	Q8N130
CCILVALSWRGGFIH	OR4M2B	141	A0A0X1KG70
FICLLLCHWIGTASP	MEGF10	11	Q96KG7
ALLALWLCCATPAHA	NOTCH2NLB	11	P0DPK3
ALLALWLCCAAPAHA	NOTCH2	11	Q04721
GHLAPVLRCGECWRA	FAM201A	21	Q5SY85
SGNPLHCSCALRWLQ	NTRK1	146	P04629
LPFCVSWEIRHLLCE	OR2AG2	166	A6NM03
WIPLCRHRLVDHFFC	OR2J1	166	Q9GZK6
TPLFCCWLVKDLLHS	PASK	921	Q96RG2
SPTFCEHCGTLLWGL	PRKCQ	241	Q04759
NKAHCIPIRWLCDGI	LRP1B	3641	Q9NZR2
ACCSGPRRHFPWNLI	FAIM2	156	Q9BWQ8
CEFTRLHGCLRLSWG	MYADML2	71	A6NDP7
LHCSGRPLFYWLTGC	LYZL6	131	O75951
LGLGLLPAHSWHCLC	LPAR2	156	Q9HBW0
PTFCDHCGSLLWGLV	PRKCD	241	Q05655
ALHDNPWVCDCRLRG	LRIT2	196	A6NDA9
RLVAACSAWLCPGLR	AUH	21	Q13825
LELRLWHEGCPARLC	CRB2	531	Q5IJ48
SHCLFLHEGWPLCLR	KIAA1755	71	Q5JYT7
WSCTCDLHPLARFLR	LRRC53	216	A6NM62
GNPLHCNCELLWLRR	LRFN1	251	Q9P244
LHGNPIRCDCVIRWA	LRRN2	366	O75325
LCHPSIVNGIAWCRL	HERC1	3666	Q15751
RGDHLGCWALRPECL	LETM1	66	O95202
FLVCADCEIGPIGWH	RABIF	91	P47224
FWHLTLPERRGTCAD	CASP6	56	P55212
LRTAHLGANPWRCDC	GP1BB	81	P13224
CLAPFDLSLWACIAG	GRID2	561	O43424
SCPHRGAECLLPWAA	MYH7B	11	A7E2Y1
HSCRPGWFQLGKECL	PCSK5	1536	Q92824
CLAHRDPYCGWCVLL	PLXNB1	491	O43157
ASFHCWLELPGELRG	PLXNB3	716	Q9ULL4
IFPVPSAGHCWKCLL	KSR1	501	Q8IVT5
CCILVALSWRGGFIH	OR4M2	141	Q8NGB6
PHCTAFWLLVDLNRC	COIL	21	P38432
CDPQLLHHLCWGPLR	PI4KA	1206	P42356
GIPSHEICDGWLCAR	KDM4C	731	Q9H3R0
SLDRCLLALCPHWYP	GPR152	126	Q8TDT2
IEPEHIWTCNKFRCG	ENPP1	141	P22413
PCSLLCLLHWGTCIL	MSLNL	651	Q96KJ4
RFHCPACWEQELSIR	PLA2G4B	191	P0C869
AKGCILWFLCHPVLA	GPR180	361	Q86V85
WVPLCGHRLVDHFFC	OR2J2	166	O76002
LVLWLPACVAAHGFR	PRADC1	11	Q9BSG0
LGCCPWLTAIFRLHD	TMEM63A	111	O94886
PSVIWEAKCRHLGCI	IL17A	86	Q16552
PRHLTTCVCALTWAL	MRGPRE	136	Q86SM8
LLLCHWDGCLQFLVP	HCN4	426	Q9Y3Q4
VLLCSAPAHGLWCQD	LY6H	16	O94772
WSLLHTECLPEICAG	RELN	601	P78509
LLRWFHDCLGFCHLP	HPDL	176	Q96IR7
FLDAHCECTLGWLEP	GALNT13	206	Q8IUC8
FVLSKRWTHLPCGCI	GPR149	361	Q86SP6
CRPRHASAVLCALVW	MRGPRG	116	Q86SM5
WQPAFTCLALLGCFL	F2RL3	241	Q96RI0
SCIALDRWYAICHPL	HCRTR2	146	O43614
HCECTVGWLEPLLAR	GALNT1	211	Q10472
FCGGALIHPCWVLTA	HABP2	346	Q14520
HGGLCLWLCVFTPFF	CHRNA6	11	Q15825
WGCALDALHRSPCVA	CRNKL1	56	Q9BZJ0
LLLCHWDGCLQFLVP	HCN1	306	O60741
VLFLFCCLGGWLASH	IL31	11	Q6EBC2
CCLGGWLASHTLPVR	IL31	16	Q6EBC2
LAAAWCLHCIAVALP	HEATR5A	461	Q86XA9
AKLCRPDAEVWCLFG	ILVBL	506	A1L0T0
CDCQAHLLWNRPRFG	PRMT7	366	Q9NVM4
LLLCLAQLWGCHSAP	AHSG	6	P02765
ELFVHPLWNRSCVAC	CELA3A	106	P09093
HCECFHGWLEPLLAR	GALNT6	271	Q8NCL4
VLLCPCVLGAALHLW	B3GALNT2	6	Q8NCR0
IEWRHLKPFCCGITN	CPAMD8	176	Q8IZJ3
PRGCLYLKDWHLCRD	JMJD4	176	Q9H9V9
AWFLPPACLSHCVRL	FAM120C	211	Q9NX05
AFLHGNPWLCNCEIL	GP1BA	216	P07359
RLLRFELCWPAHCLT	CEP192	2161	Q8TEP8
RCPCLGPFVSHFWLH	DCST2	581	Q5T1A1
PFHCDCQLLPLHRWL	CHADL	676	Q6NUI6
CLIGDHLLLRCCPLW	HELZ2	2606	Q9BYK8
CCPLWRSLLDFCEAQ	HELZ2	2616	Q9BYK8
PRLRHISLCCVVVWF	SLC22A7	341	Q9Y694
PILGWNCLGHLEACS	S1PR2	166	O95136
ALAVFRVPAWACLLC	SPACA6	16	W5XKT8
GWICDPCHLARVVKI	MLPH	101	Q9BV36
FRSLHCLLYPDTPWC	MFNG	301	O00587
HTLLALCSPGCYRIW	PRR14L	1821	Q5THK1
HIKRPWGICVGFLCQ	SLC10A2	61	Q12908
SCFCGFLLVLPEIAW	OR6K6	176	Q8NGW6
CRHLFHKSCVDPWLL	RNF150	296	Q9ULK6
LICPLCRSKWRSHDF	MAP3K1	486	Q13233
SECQHLIRWCLALRP	PIM1	261	P11309
LILRFCCEWEHRIGA	STK38	356	Q15208
HNFCLACLGALWPHR	TRIM47	26	Q96LD4
GLAVAFCCLHFDLPW	TLR10	591	Q9BXR5
CFLLLSPHCCFLWVG	SVIL	1471	O95425
DQWIRFFLKCCLLHG	TCP11X2	331	Q5H9J9
LAPHCSFARWLLCNG	TMEM161A	21	Q9NX61
LWGRCHPGRCALFLI	TMEM238L	6	A6NJY4
PFCPHLCEHIWTLLG	LARS1	861	Q9P2J5
LLENFAAAIPGHRCW	SLC22A10	36	Q63ZE4
SCALWTLLCAPEHGR	PIGQ	591	Q9BRB3
PVACFLSWCRRVGLE	SETD6	21	Q8TBK2
AWCSHSFREGLCRLL	SIGIRR	236	Q6IA17
HFFRDSWPLLRLSCG	OR6T1	176	Q8NGN1
LIHACGAVVAWCRLA	TMEM151A	51	Q8N4L1
HWLRLPRIFCSCPIG	PMEL	636	P40967
WGLCIFDDIIEHCSP	RANBP6	891	O60518
VGHDWAALTFCLPCA	CNFN	86	Q9BYD5
SRFCPPRKSCHDWIG	COA8	56	Q96IL0
HANPRLWLRLAECCI	CNOT10	386	Q9H9A5
TLCHLNGWGRCSIPI	SPG11	516	Q96JI7
GSPCFCIDVCPHWLL	RNF212	221	Q495C1
CIDVCPHWLLLLAFS	RNF212	226	Q495C1
GHRFCSPCLCLLWED	TRIM77	31	I1YAP6
CWAGLPLCLATCLDH	ST6GALNAC4	26	Q9H4F1
LLLHTCVPASWGLRC	PLAUR	11	Q03405
NHVAVFWLCLLCRLG	ZFHX2	231	Q9C0A1
ELGLYHCLLCAWETP	ZFHX2	866	Q9C0A1
HCLLCAWETPSRLAV	ZFHX2	871	Q9C0A1
KPLSVRTLLFEHCCW	NOD2	341	Q9HC29
RTLLFEHCCWPDVGQ	NOD2	346	Q9HC29
RTDLPDRHVCCVFWL	STUM	81	Q69YW2
ALRARCWPLLCGAHV	TBC1D10C	96	Q8IV04
LGCHPVLTVSWVLGC	ZNRF4	246	Q8WWF5
RFIDFCCLLCWAPHV	VN1R1	166	Q9GZP7
RFPSDHWGLLCNLDI	TDP2	346	O95551
FLCLASGIPCVSHVW	TP53BP1	1816	Q12888
HRALCDLGPWVKCSA	VKORC1L1	46	Q8N0U8
WLLAHCGRPQTECRH	PRKDC	1171	P78527
LSCPECWRTLEGPHF	TRIML1	51	Q8N9V2
QAFPCFLWLGLCPHH	PIPOX	241	Q9P0Z9
ALFEWHAVDPGCRLC	TBXA2R	91	P21731
LCGRHWEPLRLFCED	TRIM4	86	Q9C037
CLVSRHFLRDGWCLE	TLR5	756	O60602
VLLTRCPFWGCFSQL	TMEM101	21	Q96IK0
IRTWDLPSGCLIDCF	WDR36	646	Q8NI36
FLCSHSCRDWLPLEG	GEMIN4	921	P57678
PQGRHLCWLLCAFTL	JTB	11	O76095
GNPLHCNCELLWLRR	LRFN2	241	Q9ULH4
FSGNPLHCNCELLWL	LRFN4	231	Q6PJG9