Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionsignaling receptor complex adaptor activity

SPATA2 IRS2

7.37e-0454152GO:0030159
GeneOntologyMolecularFunctionphosphoprotein binding

THRAP3 APTX

3.40e-03117152GO:0051219
GeneOntologyMolecularFunctionsignaling adaptor activity

SPATA2 IRS2

4.12e-03129152GO:0035591
GeneOntologyMolecularFunctionphospholipid binding

PIK3C2G CLINT1 OSBPL1A

7.31e-03548153GO:0005543
GeneOntologyMolecularFunctionprotein-macromolecule adaptor activity

SPATA2 FBXO38 THRAP3 IRS2

9.23e-031160154GO:0030674
DomainPH

IRS2 OSBPL1A

2.04e-02278152SM00233
DomainPH_DOMAIN

IRS2 OSBPL1A

2.05e-02279152PS50003
DomainPH_domain

IRS2 OSBPL1A

2.07e-02280152IPR001849
Pubmed

A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning.

SPATA2 AGFG1 THRAP3 IRS2 CLINT1

5.49e-05103815526673895
Pubmed

PROTAC-mediated degradation reveals a non-catalytic function of AURORA-A kinase.

HECTD3 THRAP3 CLINT1

1.51e-0424715332989298
Pubmed

Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization.

THRAP3 IRS2 CLINT1

1.66e-0425515315324660
Pubmed

PLK4 deubiquitination by Spata2-CYLD suppresses NEK7-mediated NLRP3 inflammasome activation at the centrosome.

SPATA2 CLINT1

2.02e-044915231762063
Pubmed

A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.

AGFG1 NRDE2 THRAP3 CLINT1

2.12e-0472415436232890
Pubmed

Proximity labeling reveals dynamic changes in the SQSTM1 protein network.

SPATA2 AGFG1 CLINT1

3.29e-0432215339098523
Pubmed

SPATA2-Mediated Binding of CYLD to HOIP Enables CYLD Recruitment to Signaling Complexes.

SPATA2 THRAP3 CLINT1

4.31e-0435315327545878
CytobandEnsembl 112 genes in cytogenetic band chr1p34

HECTD3 THRAP3

4.06e-03294152chr1p34
CytobandEnsembl 112 genes in cytogenetic band chr20q13

SPATA2 CYP24A1

8.18e-03422152chr20q13
Diseasetype 2 diabetes mellitus (is_implicated_in)

PIK3C2G IRS2

3.34e-03171152DOID:9352 (is_implicated_in)
Diseasemean reticulocyte volume

FBXO38 IRS2 CLINT1

7.06e-03799153EFO_0010701
DiseaseIschemic stroke

PIK3C2G OSBPL1A

1.15e-02324152HP_0002140
Diseasevitamin D measurement

COG5 CYP24A1

1.23e-02336152EFO_0004631

Protein segments in the cluster

PeptideGeneStartEntry
KDKYPKARYHWLVLP

APTX

206

Q7Z2E3
PLLLSEEKKRYLWFY

PIK3C2G

666

O75747
PKLSKRYYWERERKP

OVOS1

951

Q6IE37
RYSERYDPEPKSKWD

CLINT1

171

Q14677
IRYGPWYFEPKLGKK

FAM47B

546

Q8NA70
DKKPDPANWEYKSLY

NRDE2

166

Q9H7Z3
IYKALKRYEGPLWKS

OSBPL1A

231

Q9BXW6
SEEDLKKYPKYPWGR

FBXO38

1071

Q6PIJ6
PRLEYYESEKKWRSK

IRS2

71

Q9Y4H2
GEYPKLLRLYNDLWK

COG5

411

Q9UP83
PQRLEIKPWKAYRDY

CYP24A1

126

Q07973
FLQEKYEKKRWYVPP

AGFG1

116

P52594
AYDSYWESRKPPLKA

SPATA2

256

Q9UM82
EEEWDPEYTPKSKKY

THRAP3

866

Q9Y2W1
LKPSDKYEKPLDYRW

HECTD3

506

Q5T447
DPWCPKEYYEDIKKD

LDAH

271

Q9H6V9