Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionvoltage-gated monoatomic ion channel activity

KCNH6 PTK2B KCNJ18 KCNA4 CALHM1

6.03e-05182465GO:0005244
GeneOntologyMolecularFunctionvoltage-gated channel activity

KCNH6 PTK2B KCNJ18 KCNA4 CALHM1

6.35e-05184465GO:0022832
GeneOntologyMolecularFunctionligand-gated monoatomic ion channel activity

KCNH6 PTK2B KCNJ18 CALHM1 ITPR1

7.96e-05193465GO:0015276
GeneOntologyMolecularFunctionligand-gated channel activity

KCNH6 PTK2B KCNJ18 CALHM1 ITPR1

8.77e-05197465GO:0022834
GeneOntologyMolecularFunctiongated channel activity

KCNH6 PTK2B KCNJ18 KCNA4 CALHM1 ITPR1

1.12e-04334466GO:0022836
GeneOntologyMolecularFunctionligand-gated monoatomic cation channel activity

KCNH6 KCNJ18 CALHM1 ITPR1

3.01e-04140464GO:0099094
GeneOntologyMolecularFunctionvoltage-gated monoatomic cation channel activity

KCNH6 KCNJ18 KCNA4 CALHM1

4.11e-04152464GO:0022843
GeneOntologyMolecularFunctionATP-dependent activity

NAV2 NAV1 MYO15A MYO1D MCM8 ABCA12 DNAH7

4.74e-04614467GO:0140657
GeneOntologyMolecularFunctioninorganic cation transmembrane transporter activity

KCNH6 PTK2B KCNJ18 KCNA4 SLC30A9 CALHM1 ITPR1

5.37e-04627467GO:0022890
GeneOntologyMolecularFunctionmonoatomic ion channel activity

KCNH6 PTK2B KCNJ18 KCNA4 CALHM1 ITPR1

6.14e-04459466GO:0005216
GeneOntologyMolecularFunctionmetal ion transmembrane transporter activity

KCNH6 KCNJ18 KCNA4 SLC30A9 CALHM1 ITPR1

6.57e-04465466GO:0046873
GeneOntologyMolecularFunctionmonoatomic cation channel activity

KCNH6 KCNJ18 KCNA4 CALHM1 ITPR1

1.12e-03343465GO:0005261
GeneOntologyMolecularFunctionchannel activity

KCNH6 PTK2B KCNJ18 KCNA4 CALHM1 ITPR1

1.23e-03525466GO:0015267
GeneOntologyMolecularFunctionpassive transmembrane transporter activity

KCNH6 PTK2B KCNJ18 KCNA4 CALHM1 ITPR1

1.24e-03526466GO:0022803
GeneOntologyMolecularFunctioninorganic molecular entity transmembrane transporter activity

KCNH6 PTK2B KCNJ18 KCNA4 SLC30A9 CALHM1 ITPR1

1.63e-03758467GO:0015318
GeneOntologyMolecularFunctionvoltage-gated potassium channel activity

KCNH6 KCNJ18 KCNA4

1.67e-03102463GO:0005249
GeneOntologyMolecularFunctioninward rectifier potassium channel activity

KCNH6 KCNJ18

1.89e-0328462GO:0005242
GeneOntologyMolecularFunctioncalmodulin binding

ASPM PPP3CA MYO15A MYO1D

1.92e-03230464GO:0005516
GeneOntologyMolecularFunctionmonoatomic ion transmembrane transporter activity

KCNH6 PTK2B KCNJ18 KCNA4 SLC30A9 CALHM1 ITPR1

2.10e-03793467GO:0015075
GeneOntologyMolecularFunctioncytoskeletal motor activity

MYO15A MYO1D DNAH7

2.54e-03118463GO:0003774
GeneOntologyMolecularFunctionpotassium channel activity

KCNH6 KCNJ18 KCNA4

3.19e-03128463GO:0005267
GeneOntologyMolecularFunctionATP hydrolysis activity

NAV2 NAV1 MCM8 ABCA12 DNAH7

3.34e-03441465GO:0016887
GeneOntologyMolecularFunctionmicrofilament motor activity

MYO15A MYO1D

3.46e-0338462GO:0000146
GeneOntologyMolecularFunctionmonoatomic cation transmembrane transporter activity

KCNH6 KCNJ18 KCNA4 SLC30A9 CALHM1 ITPR1

3.99e-03664466GO:0008324
GeneOntologyCellularComponentcalcineurin complex

PPP3CA ITPR1

6.76e-056452GO:0005955
DomainAAA+_ATPase

NAV2 NAV1 MCM8 ABCA12 DNAH7

2.17e-05144445IPR003593
DomainAAA

NAV2 NAV1 MCM8 ABCA12 DNAH7

2.17e-05144445SM00382
DomainP-loop_NTPase

ASPM NAV2 NAV1 MYO15A MYO1D MCM8 ABCA12 DNAH7 URGCP

1.33e-04848449IPR027417
DomainARM-type_fold

ASPM RANBP17 PI4KA MROH2B ITPR1 INTS1

1.35e-04339446IPR016024
DomainIQ

ASPM MYO15A MYO1D

6.23e-0471443PF00612
DomainIQ

ASPM MYO15A MYO1D

9.16e-0481443SM00015
DomainIQ_motif_EF-hand-BS

ASPM MYO15A MYO1D

1.24e-0390443IPR000048
DomainIQ

ASPM MYO15A MYO1D

1.37e-0393443PS50096
Domain-

NAV2 NAV1 MYO15A MCM8 ABCA12 DNAH7 URGCP

1.66e-037464473.40.50.300
DomainIon_trans_dom

KCNH6 KCNA4 ITPR1

2.44e-03114443IPR005821
DomainIon_trans

KCNH6 KCNA4 ITPR1

2.44e-03114443PF00520
DomaincNMP

KCNH6 RAPGEF2

2.90e-0334442SM00100
DomaincNMP_binding

KCNH6 RAPGEF2

2.90e-0334442PF00027
DomaincNMP-bd_dom

KCNH6 RAPGEF2

3.07e-0335442IPR000595
DomainCNMP_BINDING_3

KCNH6 RAPGEF2

3.07e-0335442PS50042
DomainMYOSIN_MOTOR

MYO15A MYO1D

3.61e-0338442PS51456
DomainMyosin_head

MYO15A MYO1D

3.61e-0338442PF00063
DomainMyosin_head_motor_dom

MYO15A MYO1D

3.61e-0338442IPR001609
DomaincNMP-bd-like

KCNH6 RAPGEF2

3.61e-0338442IPR018490
DomainMYSc

MYO15A MYO1D

3.61e-0338442SM00242
DomainFERM_M

PTK2B MYO15A

5.26e-0346442PF00373
Domain-

KCNH6 RAPGEF2

5.71e-03484422.60.120.10
DomainFERM_central

PTK2B MYO15A

5.95e-0349442IPR019748
DomainFERM_domain

PTK2B MYO15A

5.95e-0349442IPR000299
DomainFERM_1

PTK2B MYO15A

6.18e-0350442PS00660
DomainFERM_2

PTK2B MYO15A

6.18e-0350442PS00661
DomainBand_41_domain

PTK2B MYO15A

6.18e-0350442IPR019749
DomainB41

PTK2B MYO15A

6.18e-0350442SM00295
DomainFERM_3

PTK2B MYO15A

6.18e-0350442PS50057
DomainRmlC-like_jellyroll

KCNH6 RAPGEF2

6.43e-0351442IPR014710
DomainCH

ASPM NAV2

1.03e-0265442SM00033
DomainCH

ASPM NAV2

1.18e-0270442PF00307
Domain-

ASPM NAV2

1.22e-02714421.10.418.10
DomainCH

ASPM NAV2

1.28e-0273442PS50021
DomainCH-domain

ASPM NAV2

1.35e-0275442IPR001715
Pubmed

Calcineurin is essential for depolarization-induced nuclear translocation and tyrosine phosphorylation of PYK2 in neurons.

PTK2B PPP3CA

1.71e-06246217684059
Pubmed

Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling.

PTK2B PPP3CA KCNA4 RAPGEF2 PI4KA DLGAP4

1.88e-0628146628706196
Pubmed

Pore membrane and/or filament interacting like protein 1 (POMFIL1) is predominantly expressed in the nervous system and encodes different protein isoforms.

NAV2 NAV1

5.13e-06346212062803
Pubmed

Calcium-dependent interaction of calcineurin with Bcl-2 in neuronal tissue.

PPP3CA ITPR1

5.13e-06346212617961
Pubmed

Calcineurin associated with the inositol 1,4,5-trisphosphate receptor-FKBP12 complex modulates Ca2+ flux.

PPP3CA ITPR1

5.13e-0634628521476
Pubmed

Neuron navigator: a human gene family with homology to unc-53, a cell guidance gene from Caenorhabditis elegans.

NAV2 NAV1

5.13e-06346212079279
Pubmed

Sensory deficits in mice hypomorphic for a mammalian homologue of unc-53.

NAV2 NAV1

5.13e-06346215158073
Pubmed

The BH4 domain of Bcl-2 inhibits ER calcium release and apoptosis by binding the regulatory and coupling domain of the IP3 receptor.

PPP3CA ITPR1

1.71e-05546219706527
Pubmed

Genetic mapping refines DFNB3 to 17p11.2, suggests multiple alleles of DFNB3, and supports homology to the mouse model shaker-2.

KCNJ18 MYO15A

2.56e-0564629529344
Pubmed

Myosins: a diverse superfamily.

MYO15A MYO1D

3.58e-05746210722873
Pubmed

Inositol-1,4,5-trisphosphate receptor regulates hepatic gluconeogenesis in fasting and diabetes.

PPP3CA ITPR1

3.58e-05746222495310
Pubmed

Dynamic microtubules catalyze formation of navigator-TRIO complexes to regulate neurite extension.

NAV2 NAV1

3.58e-05746225065758
Pubmed

Combinatorial CRISPR screen identifies fitness effects of gene paralogues.

ASPM NAV1 RANBP17 SKP2

1.08e-0418646433637726
Pubmed

A physical map of the mouse shaker-2 region contains many of the genes commonly deleted in Smith-Magenis syndrome (del17p11.2p11.2).

KCNJ18 MYO15A

1.32e-041346210049592
Pubmed

Circular rapid amplification of cDNA ends for high-throughput extension cloning of partial genes.

COL4A1 KCNH6 URGCP

1.91e-048446315203218
Pubmed

Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.

NAV1 PPP3CA KCNA4 RAPGEF2 GABBR2 PI4KA DLGAP4

2.55e-0496346728671696
Pubmed

FBXW7 Triggers Degradation of KMT2D to Favor Growth of Diffuse Large B-cell Lymphoma Cells.

SKP2 KDM6A

3.20e-042046232350066
Pubmed

Long-term potentiation modulates synaptic phosphorylation networks and reshapes the structure of the postsynaptic interactome.

PPP3CA KCNA4 RAPGEF2 DLGAP4

3.41e-0425146427507650
Pubmed

E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.

RBM28 OR13C8 PI4KA HNRNPL INTS1 TBC1D14

4.01e-0473646629676528
Pubmed

Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.

PPP3CA MYO1D CCDC61 KDM6A PI4KA HNRNPL ITPR1

4.27e-04104946727880917
Pubmed

Human origin recognition complex large subunit is degraded by ubiquitin-mediated proteolysis after initiation of DNA replication.

MCM8 SKP2

5.45e-042646211931757
Pubmed

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

NAV1 RANBP17 PPP3CA RAPGEF2 MCM8 KDM6A HNRNPL TBC1D14

6.77e-04148946828611215
Pubmed

Embryonic forebrain transcriptome of mice with polyalanine expansion mutations in the ARX homeobox gene.

ASPM GABBR2

7.77e-043146227798109
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

NAV2 NAV1 PTK2B RAPGEF2 DNAH7 PI4KA

9.11e-0486146636931259
Pubmed

Transgenic mouse proteomics identifies new 14-3-3-associated proteins involved in cytoskeletal rearrangements and cell signaling.

PPP3CA RAPGEF2 ITPR1

9.83e-0414746316959763
Pubmed

Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.

ASPM NAV1 PPP3CA MYO1D PI4KA

1.05e-0358846538580884
Pubmed

Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro.

NAV2 INTS1 TBC1D14

1.10e-0315346310718198
Pubmed

International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels.

KCNH6 KCNA4

1.29e-034046216382104
Cytoband7p22.3

COX19 INTS1

5.17e-04344527p22.3
GeneFamilyPotassium voltage-gated channels

KCNH6 KCNA4

2.41e-0340332274
GeneFamilyOlfactory receptors, family 52

OR52N2 OR52N5

3.60e-0349332165
GeneFamilyAnkyrin repeat domain containing|FERM domain containing

PTK2B MYO15A

3.75e-03503321293
CoexpressionLAKE_ADULT_KIDNEY_C20_COLLECTING_DUCT_INTERCALATED_CELLS_TYPE_A_CORTEX

PPP3CA RAPGEF2 MYO1D ITPR1 TBC1D14

5.56e-06152445M39239
ToppCellParenchymal-NucSeq|Parenchymal / Cell types per location group and 10X technology with lineage, and cell group designations

NAV2 RANBP17 RAPGEF2 MYO1D KDM6A

1.66e-061984551996373bdccc55aac347d349bd22f6aad6d0c668
Diseasechromosome 22q11.2 deletion syndrome, distal (implicated_via_orthology)

PI4KAP2 PI4KA

1.96e-0414442DOID:0060413 (implicated_via_orthology)
Diseasesphingosine 1-phosphate measurement

KDM6A ITPR1

3.27e-0418442EFO_0800185
Diseaseresponse to ziprasidone

PPP3CA GCNT4

4.06e-0420442GO_0097337
Diseaseresponse to TNF antagonist, joint damage measurement

NAV2 GABBR2

6.38e-0425442EFO_0004653, EFO_0005413
DiseaseHyalinosis, Segmental Glomerular

COL4A1 ZMPSTE24

8.01e-0428442C0086432
DiseaseMalignant Neoplasms

UGT1A1 SKP2 KDM6A

9.27e-04128443C0006826
DiseaseFocal glomerulosclerosis

COL4A1 ZMPSTE24

1.33e-0336442C0017668

Protein segments in the cluster

PeptideGeneStartEntry
FKQFNIFCHMLESAL

CCDC61

61

Q9Y6R9
FLGRNVFNKFCLSNM

ABCA12

201

Q86UK0
NNMYDIFNLNDKALC

ADGRG3

36

Q86Y34
AFAKVCIQQFFEAMN

CALHM1

241

Q8IU99
LLMSQKFQQFRGLCE

DLGAP4

851

Q9Y2H0
QKCAALRIQFFLQMA

ASPM

2836

Q8IZT6
KFSTMPFLFCNINNV

COL4A1

1496

P02462
MQVLKLVLNCLNFDF

RANBP17

216

Q9H2T7
AQFMTQEAAQKCLLA

RBM28

381

Q9NW13
NKNDKCMFLLYIEAN

MCM8

346

Q9UJA3
NFQAFCLGLMQERKE

INTS1

511

Q8N201
GAFNVCNKIIFLMSF

ITPR1

2366

Q14643
NLAFAKMLDAKQNQC

MYO15A

1296

Q9UKN7
VLNDFCEKNNLNFLM

KDM6A

1176

O15550
SRKFLIANAQMENCA

KCNH6

26

Q9H252
KFMKCLHNNNFENAL

COX19

36

Q49B96
ANFIMKVIQSCFLSN

PI4KA

2071

P42356
LKEIDFNACLAQMFF

OR52N2

91

Q8NGI0
FCFKERLQAVDLMNQ

CCDC105

236

Q8IYK2
FAVNNMFVSKSLRCA

GSKIP

46

Q9P0R6
LQANKATLVCLMNDF

IGLL1

126

P15814
TFKVAMNNLAKCFSN

GCNT4

171

Q9P109
MNNLAKCFSNIFIAS

GCNT4

176

Q9P109
FNCAAALMTLQLQDL

DNAH7

361

Q8WXX0
MKNCQFQEQLLSFFM

IL26

76

Q9NPH9
ACAQKQLHFMDQLLD

HAUS7

121

Q99871
KAVKNFCDANNLMFI

MANEAL

341

Q5VSG8
NNFMFGQKLNVCVSK

HNRNPL

441

P14866
ILGQFDQNMAAKVFC

GABBR2

251

O75899
CVMKFFNTLAGFANI

PTK2B

246

Q14289
VKNIIISQMNSFLCF

ZMPSTE24

346

O75844
AFDCLPLAALMNQQF

PPP3CA

181

Q08209
FSLKEINFNACLAQM

OR52N5

96

Q8NH56
AFAMQLPFCANNVIK

OR13C8

161

Q8NGS7
FNMHQQSCKDLQLYL

NAV1

1591

Q8NEY1
SFKNLENKPVFMFCQ

TAS2R45

251

P59539
FVKKNGQCNIAFANM

KCNJ18

46

B7U540
MIENIDACLNFLAAK

NAV2

146

Q8IVL1
QNQEKFFMNRCKSLF

MROH2B

676

Q7Z745
ANFIMKVIQSCFLSN

PI4KAP2

561

A4QPH2
VMLKNDCFQEFFQLN

SKP2

321

Q13309
AFIAFSNLLNKPCQM

TBC1D14

526

Q9P2M4
CKNFNSMFAIISGLN

RAPGEF2

801

Q9Y4G8
SFLQQEIALKMALCQ

URGCP

196

Q8TCY9
KNMLIAFSQNFLCDV

UGT1A1

211

P22309
MVAICINGLNCFFKF

SLC30A9

241

Q6PML9
FACPSQALFFKNIMN

KCNA4

391

P22459
NMLLKSNCVLEAFGN

MYO1D

136

O94832