Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyCellularComponent	laminin-1 complex	LAMA1 LAMC1	8.35e-05	3	111	2	GO:0005606
GeneOntologyCellularComponent	protein complex involved in cell-matrix adhesion	LAMA1 LAMC1 PLAU	9.39e-05	17	111	3	GO:0098637
GeneOntologyCellularComponent	protein complex involved in cell adhesion	LAMA1 ITGA6 LAMC1 PLAU	2.74e-04	59	111	4	GO:0098636
Domain	Groucho_enhance	TLE1 TLE2 TLE3	1.92e-06	5	109	3	IPR009146
Domain	TLE_N	TLE1 TLE2 TLE3	1.92e-06	5	109	3	PF03920
Domain	Groucho/TLE_N	TLE1 TLE2 TLE3	1.92e-06	5	109	3	IPR005617
Domain	SMAD_FHA_domain	PHF12 KIF1B SMAD3 SMAD9 KIF1C	1.29e-05	52	109	5	IPR008984
Domain	DUF4599	SPATA31A3 SPATA31A7 SPATA31A5	4.09e-05	12	109	3	PF15371
Domain	DUF4599	SPATA31A3 SPATA31A7 SPATA31A5	4.09e-05	12	109	3	IPR027970
Domain	Kinesin_assoc	KIF1B KIF1C	4.99e-04	6	109	2	PF16183
Domain	Kinesin_assoc	KIF1B KIF1C	4.99e-04	6	109	2	IPR032405
Domain	FHA_DOMAIN	PHF12 KIF1B KIF1C	7.72e-04	31	109	3	PS50006
Domain	Prefoldin	KIF21B TLE1 TLE2 TLE3	8.32e-04	72	109	4	IPR009053
Domain	DWB	SMAD3 SMAD9	9.24e-04	8	109	2	SM00524
Domain	MH2	SMAD3 SMAD9	9.24e-04	8	109	2	PS51076
Domain	MH1	SMAD3 SMAD9	9.24e-04	8	109	2	PS51075
Domain	-	SMAD3 SMAD9	9.24e-04	8	109	2	3.90.520.10
Domain	MAD_homology_MH1	SMAD3 SMAD9	9.24e-04	8	109	2	IPR013019
Domain	Dwarfin	SMAD3 SMAD9	9.24e-04	8	109	2	IPR013790
Domain	LAMININ_IVA	LAMA1 LAMC1	9.24e-04	8	109	2	PS51115
Domain	Laminin_B	LAMA1 LAMC1	9.24e-04	8	109	2	PF00052
Domain	LamB	LAMA1 LAMC1	9.24e-04	8	109	2	SM00281
Domain	MH2	SMAD3 SMAD9	9.24e-04	8	109	2	PF03166
Domain	SMAD_dom_Dwarfin-type	SMAD3 SMAD9	9.24e-04	8	109	2	IPR001132
Domain	Laminin_IV	LAMA1 LAMC1	9.24e-04	8	109	2	IPR000034
Domain	-	PHF12 KIF1B KIF1C	1.20e-03	36	109	3	2.60.200.20
Domain	FHA_dom	PHF12 KIF1B KIF1C	1.20e-03	36	109	3	IPR000253
Domain	Kinesin_motor_CS	KIF21B KIF1B KIF1C	1.75e-03	41	109	3	IPR019821
Domain	Kinesin-like_fam	KIF21B KIF1B KIF1C	2.01e-03	43	109	3	IPR027640
Domain	MAD_homology1_Dwarfin-type	SMAD3 SMAD9	2.14e-03	12	109	2	IPR003619
Domain	DWA	SMAD3 SMAD9	2.14e-03	12	109	2	SM00523
Domain	MH1	SMAD3 SMAD9	2.14e-03	12	109	2	PF03165
Domain	-	KIF21B KIF1B KIF1C	2.15e-03	44	109	3	3.40.850.10
Domain	Kinesin	KIF21B KIF1B KIF1C	2.15e-03	44	109	3	PF00225
Domain	KISc	KIF21B KIF1B KIF1C	2.15e-03	44	109	3	SM00129
Domain	KINESIN_MOTOR_1	KIF21B KIF1B KIF1C	2.15e-03	44	109	3	PS00411
Domain	Kinesin_motor_dom	KIF21B KIF1B KIF1C	2.15e-03	44	109	3	IPR001752
Domain	KINESIN_MOTOR_2	KIF21B KIF1B KIF1C	2.15e-03	44	109	3	PS50067
Domain	Laminin_N	LAMA1 LAMC1	3.84e-03	16	109	2	IPR008211
Domain	SMAD_dom-like	SMAD3 SMAD9	3.84e-03	16	109	2	IPR017855
Domain	-	SMAD3 SMAD9	3.84e-03	16	109	2	2.60.200.10
Domain	LamNT	LAMA1 LAMC1	3.84e-03	16	109	2	SM00136
Domain	LAMININ_NTER	LAMA1 LAMC1	3.84e-03	16	109	2	PS51117
Domain	Laminin_N	LAMA1 LAMC1	3.84e-03	16	109	2	PF00055
Pathway	REACTOME_REPRESSION_OF_WNT_TARGET_GENES	TLE1 TLE2 TLE3 CTBP1	1.97e-07	10	80	4	MM15156
Pathway	REACTOME_REPRESSION_OF_WNT_TARGET_GENES	TLE1 TLE2 TLE3 CTBP1	9.22e-07	14	80	4	M27402
Pathway	REACTOME_DEACTIVATION_OF_THE_BETA_CATENIN_TRANSACTIVATING_COMPLEX	XIAP TLE1 TLE2 TLE3 CTBP1	9.26e-07	32	80	5	MM14975
Pathway	REACTOME_DEACTIVATION_OF_THE_BETA_CATENIN_TRANSACTIVATING_COMPLEX	XIAP TLE1 TLE2 TLE3 CTBP1	3.74e-06	42	80	5	M27272
Pathway	PID_INTEGRIN4_PATHWAY	LAMA1 ITGA6 LAMC1	2.81e-05	11	80	3	M158
Pathway	WP_ALPHA_6_BETA_4_SIGNALING	LAMA1 SHC1 ITGA6 LAMC1	3.47e-05	33	80	4	M39503
Pathway	WP_ALPHA_6_BETA_4_INTEGRIN_SIGNALING_PATHWAY	LAMA1 SHC1 ITGA6 LAMC1 SMAD3	3.54e-05	66	80	5	MM15925
Pathway	PID_A6B1_A6B4_INTEGRIN_PATHWAY	LAMA1 SHC1 ITGA6 LAMC1	1.31e-04	46	80	4	M239
Pathway	WNT_SIGNALING	WNT6 TLE1 TLE2 CTBP1 SENP2	1.48e-04	89	80	5	M5493
Pathway	REACTOME_FORMATION_OF_THE_BETA_CATENIN_TCF_TRANSACTIVATING_COMPLEX	TLE1 TLE2 TLE3	4.16e-04	26	80	3	MM14793
Pubmed	The testis-specific VAD1.3/AEP1 interacts with β-actin and syntaxin 1 and directs peri-nuclear/Golgi expression with bipartite nucleus localization (BNL) sequence.	SPATA31A3 SPATA31A7 SPATA31A5 SPATA31A1	1.75e-09	6	116	4	20850414
Pubmed	Targeted disruption of the spermatid-specific gene Spata31 causes male infertility.	SPATA31A3 SPATA31A7 SPATA31A5 SPATA31A1	1.75e-09	6	116	4	25930072
Pubmed	Epithelial expression and chromosomal location of human TLE genes: implications for notch signaling and neoplasia.	TLE1 TLE2 TLE3	3.62e-08	3	116	3	8808280
Pubmed	TLE expression correlates with mouse embryonic segmentation, neurogenesis, and epithelial determination.	TLE1 TLE2 TLE3	1.44e-07	4	116	3	8645603
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	SAMD1 PHF12 LAMC1 ECPAS TLE1 TLE3 GEMIN4 CCT8 ANKRD28 CTBP1 VCPIP1	1.68e-07	418	116	11	34709266
Pubmed	Human homologs of a Drosophila Enhancer of split gene product define a novel family of nuclear proteins.	TLE1 TLE2 TLE3	3.60e-07	5	116	3	1303260
Pubmed	Molecular cloning and expression of mouse and human cDNA encoding AES and ESG proteins with strong similarity to Drosophila enhancer of split groucho protein.	TLE1 TLE2 TLE3	3.60e-07	5	116	3	8365415
Pubmed	The expression of the genes for entactin, laminin A, laminin B1 and laminin B2 in murine lens morphogenesis and eye development.	LAMA1 ITGA6 LAMC1	3.60e-07	5	116	3	1725162
Pubmed	Protein characterization and targeted disruption of Grg, a mouse gene related to the groucho transcript of the Drosophila Enhancer of split complex.	TLE1 TLE2 TLE3	7.18e-07	6	116	3	8573724
Pubmed	Majority of cerebrospinal fluid-contacting neurons in the spinal cord of C57Bl/6N mice is present in ectopic position unlike in other studied experimental mice strains and mammalian species.	SPATA31A3 SPATA31A7 SPATA31A5 SPATA31A1	1.19e-06	24	116	4	32212159
Pubmed	A Gro/TLE-NuRD corepressor complex facilitates Tbx20-dependent transcriptional repression.	TLE1 TLE2 TLE3	1.25e-06	7	116	3	24024827
Pubmed	Abscence of laminin alpha1 chain in the skeletal muscle of dystrophic dy/dy mice.	LAMA1 ITGA6 LAMC1	1.25e-06	7	116	3	9390664
Pubmed	Differential expression of laminin chain-specific mRNA transcripts during mouse preimplantation embryo development.	LAMA1 ITGA6 LAMC1	1.25e-06	7	116	3	8722691
Pubmed	Differential expression of integrin alpha subunits supports distinct roles during lung branching morphogenesis.	LAMA1 ITGA6 LAMC1	2.00e-06	8	116	3	8725284
Pubmed	Nolz1 promotes striatal neurogenesis through the regulation of retinoic acid signaling.	TLE1 TLE2 TLE3	2.00e-06	8	116	3	20735826
Pubmed	The Groucho-related gene family regulates the gonadotropin-releasing hormone gene through interaction with the homeodomain proteins MSX1 and OCT1.	TLE1 TLE2 TLE3	2.00e-06	8	116	3	16002402
Pubmed	Integrin β4 regulation of PTHrP underlies its contribution to mammary gland development.	LAMA1 ITGA6 PTHLH	2.99e-06	9	116	3	26432258
Pubmed	Laminin γ1 C-terminal Glu to Gln mutation induces early postimplantation lethality.	LAMA1 ITGA6 LAMC1	2.99e-06	9	116	3	30456378
Pubmed	Integrin-laminin interactions controlling neurite outgrowth from adult DRG neurons in vitro.	LAMA1 ITGA6 LAMC1	4.26e-06	10	116	3	18590826
Pubmed	Trophoblast-specific expression and function of the integrin alpha 7 subunit in the peri-implantation mouse embryo.	LAMA1 ITGA6 LAMC1	4.26e-06	10	116	3	11784026
Pubmed	Spatial distribution of the full-length members of the Grg family during embryonic neurogenesis reveals a "Grg-mediated repression map" in the mouse telencephalon.	TLE1 TLE2 TLE3	4.26e-06	10	116	3	30571765
Pubmed	Integrin alpha6beta1-laminin interactions regulate early myotome formation in the mouse embryo.	LAMA1 ITGA6 LAMC1	4.26e-06	10	116	3	16554364
Pubmed	Coexpression of Cux-1 and Notch signaling pathway components during kidney development.	TLE1 TLE2 TLE3	5.85e-06	11	116	3	15499562
Pubmed	All Tcf HMG box transcription factors interact with Groucho-related co-repressors.	TLE1 TLE2 TLE3	7.78e-06	12	116	3	11266540
Pubmed	Thyroid follicle development requires Smad1/5- and endothelial cell-dependent basement membrane assembly.	LAMA1 LAMC1 TG SMAD9	9.79e-06	40	116	4	27068110
Pubmed	Mammalian BTBD12/SLX4 assembles a Holliday junction resolvase and is required for DNA repair.	PTHLH ANKRD44 GEMIN4 SLX4IP ANKRD28	1.00e-05	85	116	5	19596235
Pubmed	The extracellular matrix controls stem cell specification and crypt morphology in the developing and adult mouse gut.	LAMA1 ITGA6 LAMC1	1.01e-05	13	116	3	36350252
Pubmed	Neurog2 simultaneously activates and represses alternative gene expression programs in the developing neocortex.	TLE1 TLE2 TLE3	1.01e-05	13	116	3	22735158
Pubmed	The Essential Role of GATA6 in the Activation of Estrogen Synthesis in Endometriosis.	GATA6 NR5A1	1.10e-05	2	116	2	29402198
Pubmed	Differential distribution of laminins in Alzheimer disease and normal human brain tissue.	LAMA1 LAMC1	1.10e-05	2	116	2	12111806
Pubmed	Selective down-regulation of the alpha6-integrin subunit in melanocytes by UVB light.	LAMA1 ITGA6	1.10e-05	2	116	2	15885076
Pubmed	Dual-vector gene therapy restores cochlear amplification and auditory sensitivity in a mouse model of DFNB16 hearing loss.	STRC STRCP1	1.10e-05	2	116	2	34910522
Pubmed	Gene mapping of mouse laminin A and B2 subunits using mouse-Chinese hamster somatic cell hybrids.	LAMA1 LAMC1	1.10e-05	2	116	2	2267633
Pubmed	Inhibition of the CtBP complex and FBXO11 enhances MHC class II expression and anti-cancer immune responses.	FBXO11 CIITA	1.10e-05	2	116	2	36179686
Pubmed	PLAU, transcriptionally negatively regulated by GATA6, promotes lung squamous carcinoma cell proliferation and migration.	GATA6 PLAU	1.10e-05	2	116	2	38702016
Pubmed	Distribution of alpha 6 integrin subunit in developing mouse submandibular gland.	LAMA1 ITGA6	1.10e-05	2	116	2	8409377
Pubmed	Mutations in a new gene encoding a protein of the hair bundle cause non-syndromic deafness at the DFNB16 locus.	STRC STRCP1	1.10e-05	2	116	2	11687802
Pubmed	Groucho/TLE family proteins and transcriptional repression.	TLE1 TLE3	1.10e-05	2	116	2	10831834
Pubmed	Differential functions of TLE1 and TLE3 depending on a specific phosphorylation site.	TLE1 TLE3	1.10e-05	2	116	2	33571907
Pubmed	Laminin chain-specific gene expression during mouse oocyte maturation.	LAMA1 LAMC1	1.10e-05	2	116	2	9291468
Pubmed	Nkx2.2-repressor activity is sufficient to specify alpha-cells and a small number of beta-cells in the pancreatic islet.	TLE1 TLE2 TLE3	1.28e-05	14	116	3	17202186
Pubmed	Conditional mutations of beta-catenin and APC reveal roles for canonical Wnt signaling in lens differentiation.	WNT6 TLE1 TLE2 CTBP1 SENP2	1.33e-05	90	116	5	19515997
Pubmed	Developmental restriction of Mash-2 expression in trophoblast correlates with potential activation of the notch-2 pathway.	TLE1 TLE2 TLE3	1.60e-05	15	116	3	9291577
Pubmed	The type I BMP receptors, Bmpr1a and Acvr1, activate multiple signaling pathways to regulate lens formation.	LAMA1 LAMC1 SMAD9	1.96e-05	16	116	3	19733164
Pubmed	Laminin alpha5 is necessary for submandibular gland epithelial morphogenesis and influences FGFR expression through beta1 integrin signaling.	LAMA1 ITGA6 LAMC1	1.96e-05	16	116	3	17601529
Pubmed	TGF-beta-1 up-regulates extra-cellular matrix production in mouse hepatoblasts.	LAMA1 LAMC1 SMAD3	2.84e-05	18	116	3	23041440
Pubmed	Groucho co-repressor proteins regulate β cell development and proliferation by repressing Foxa1 in the developing mouse pancreas.	TLE1 TLE2 TLE3	2.84e-05	18	116	3	33658226
Pubmed	Temporal regulation of a paired-like homeodomain repressor/TLE corepressor complex and a related activator is required for pituitary organogenesis.	TLE1 TLE2 TLE3	2.84e-05	18	116	3	11731482
Pubmed	The human cytoplasmic dynein interactome reveals novel activators of motility.	TROAP PHF12 KIF1B HAUS5 XIAP ECPAS MAST2 WASHC5 CCT8 ANKRD28 VCPIP1 KIF1C	2.93e-05	853	116	12	28718761
Pubmed	Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.	SAMD1 ARID4A FBXO11 ECPAS TLE1 TLE3 ANKRD28 THRAP3 AGTPBP1 HERC5 SMAD3 SMAD9	3.07e-05	857	116	12	25609649
Pubmed	Developmental loss of laminin from the interstitial extracellular matrix correlates with decreased laminin gene expression.	LAMA1 LAMC1	3.30e-05	3	116	2	2100263
Pubmed	Cochlear outer hair cell horizontal top connectors mediate mature stereocilia bundle mechanics.	STRC STRCP1	3.30e-05	3	116	2	30801007
Pubmed	Differential distribution of laminin chains in the development and sex differentiation of mouse internal genitalia.	LAMA1 LAMC1	3.30e-05	3	116	2	7669546
Pubmed	Parathyroid hormone-related protein regulates integrin α6 and β4 levels via transcriptional and post-translational pathways.	ITGA6 PTHLH	3.30e-05	3	116	2	23499737
Pubmed	Exposure of cryptic domains in the alpha 1-chain of laminin-1 by elastase stimulates macrophages urokinase and matrix metalloproteinase-9 expression.	LAMA1 PLAU	3.30e-05	3	116	2	11827968
Pubmed	Differential expression of laminin A and B chains during development of embryonic mouse organs.	LAMA1 LAMC1	3.30e-05	3	116	2	2088723
Pubmed	Differential expression of laminin isoforms and alpha 6-beta 4 integrin subunits in the developing human and mouse intestine.	LAMA1 ITGA6	3.30e-05	3	116	2	7803849
Pubmed	Laminin expression in the mouse lung increases with development and stimulates spontaneous organotypic rearrangement of mixed lung cells.	LAMA1 LAMC1	3.30e-05	3	116	2	1292752
Pubmed	Expression of laminin chains during myogenic differentiation.	LAMA1 LAMC1	3.30e-05	3	116	2	7510707
Pubmed	GATA6 promotes colon cancer cell invasion by regulating urokinase plasminogen activator gene expression.	GATA6 PLAU	3.30e-05	3	116	2	21076612
Pubmed	Sry induces cell proliferation in the mouse gonad.	LAMA1 NR5A1	3.30e-05	3	116	2	10654601
Pubmed	The Adult Murine Intestine is Dependent on Constitutive Laminin-γ1 Synthesis.	NDOR1 LAMC1	3.30e-05	3	116	2	31848396
Pubmed	Tle corepressors are differentially partitioned to instruct CD8+ T cell lineage choice and identity.	TLE1 TLE3	3.30e-05	3	116	2	30045946
Pubmed	Laminin-121--recombinant expression and interactions with integrins.	LAMA1 LAMC1	3.30e-05	3	116	2	20566382
Pubmed	Three-dimensional analysis of the developing pituitary gland in the mouse.	LAMA1 LAMC1	3.30e-05	3	116	2	9603432
Pubmed	Impaired glycolytic metabolism causes chondrocyte hypertrophy-like changes via promotion of phospho-Smad1/5/8 translocation into nucleus.	SMAD3 SMAD9	3.30e-05	3	116	2	23384547
Pubmed	Integrin α6β1 Expressed in ESCs Instructs the Differentiation to Endothelial Cells.	LAMA1 ITGA6	3.30e-05	3	116	2	25693840
Pubmed	CRISPR/Cas9 Screens Reveal Multiple Layers of B cell CD40 Regulation.	FBXO11 CTBP1	3.30e-05	3	116	2	31365872
Pubmed	SMAD3 inhibits SF-1-dependent activation of the CYP17 promoter in H295R cells.	NR5A1 SMAD3	3.30e-05	3	116	2	17786540
Pubmed	CD117-positive cells in adult human heart are localized in the subepicardium, and their activation is associated with laminin-1 and alpha6 integrin expression.	LAMA1 ITGA6	3.30e-05	3	116	2	18436868
Pubmed	Identification of laminin domains involved in branching morphogenesis: effects of anti-laminin monoclonal antibodies on mouse embryonic lung development.	LAMA1 LAMC1	3.30e-05	3	116	2	1907584
Pubmed	Human beta 2 chain of laminin (formerly S chain): cDNA cloning, chromosomal localization, and expression in carcinomas.	LAMA1 LAMC1	3.30e-05	3	116	2	7698745
Pubmed	Steroid sulfotransferase 2A1 gene transcription is regulated by steroidogenic factor 1 and GATA-6 in the human adrenal.	GATA6 NR5A1	3.30e-05	3	116	2	15388788
Pubmed	In vivo optical trapping indicates kinesin's stall force is reduced by dynein during intracellular transport.	KIF1B KIF1C	3.30e-05	3	116	2	23404705
Pubmed	PTH-related protein upregulates integrin alpha6beta4 expression and activates Akt in breast cancer cells.	ITGA6 PTHLH	3.30e-05	3	116	2	16965770
Pubmed	An association of IgG anti-laminin-1 autoantibodies with endometriosis in infertile patients.	LAMA1 LAMC1	3.30e-05	3	116	2	12615822
Pubmed	Differential expression of laminin, nidogen and collagen IV genes in the midgestation mouse placenta.	LAMA1 LAMC1	3.30e-05	3	116	2	8153091
Pubmed	GATA factors promote ER integrity and β-cell survival and contribute to type 1 diabetes risk.	NDOR1 GATA6	3.30e-05	3	116	2	24284823
Pubmed	GATA6 and FOXA2 regulate Wnt6 expression during extraembryonic endoderm formation.	WNT6 GATA6	3.30e-05	3	116	2	22607194
Pubmed	Laminin and integrin expression in the ventral ectodermal ridge of the mouse embryo: implications for regulation of BMP signalling.	LAMA1 ITGA6 LAMC1	3.95e-05	20	116	3	22911573
Pubmed	Genome-wide association analysis identifies 11 risk variants associated with the asthma with hay fever phenotype.	XKR6 PTHLH SMAD3	5.32e-05	22	116	3	24388013
Pubmed	Renal collecting system growth and function depend upon embryonic γ1 laminin expression.	LAMA1 ITGA6 LAMC1	6.10e-05	23	116	3	21903675
Pubmed	Stereocilin-deficient mice reveal the origin of cochlear waveform distortions.	STRC STRCP1	6.59e-05	4	116	2	18849963
Pubmed	Transducin-like Enhancer of split 2, a mammalian homologue of Drosophila Groucho, acts as a transcriptional repressor, interacts with Hairy/Enhancer of split proteins, and is expressed during neuronal development.	TLE1 TLE2	6.59e-05	4	116	2	9874198
Pubmed	Expression of laminin chains by central neurons: analysis with gene and protein trapping techniques.	LAMA1 LAMC1	6.59e-05	4	116	2	12820173
Pubmed	Beta-catenin directly displaces Groucho/TLE repressors from Tcf/Lef in Wnt-mediated transcription activation.	TLE1 TLE2	6.59e-05	4	116	2	15768032
Pubmed	Absence of basement membranes after targeting the LAMC1 gene results in embryonic lethality due to failure of endoderm differentiation.	LAMA1 LAMC1	6.59e-05	4	116	2	9885251
Pubmed	Regulation of cytochrome b5 gene transcription by Sp3, GATA-6, and steroidogenic factor 1 in human adrenal NCI-H295A cells.	GATA6 NR5A1	6.59e-05	4	116	2	15831526
Pubmed	USP47 deubiquitylates Groucho/TLE to promote Wnt-β-catenin signaling.	XIAP TLE3	6.59e-05	4	116	2	36749823
Pubmed	Expression patterns of laminin receptor splice variants alpha 6A beta 1 and alpha 6B beta 1 suggest different roles in mouse development.	LAMA1 ITGA6	6.59e-05	4	116	2	8573717
Pubmed	Integrin-linked kinase (ILK) is required for polarizing the epiblast, cell adhesion, and controlling actin accumulation.	LAMA1 ITGA6	6.59e-05	4	116	2	12670870
Pubmed	Signal transduction by the alpha 6 beta 4 integrin: distinct beta 4 subunit sites mediate recruitment of Shc/Grb2 and association with the cytoskeleton of hemidesmosomes.	SHC1 ITGA6	6.59e-05	4	116	2	7556090
Pubmed	Corepressors TLE1 and TLE3 interact with HESX1 and PROP1.	TLE1 TLE3	6.59e-05	4	116	2	20181723
Pubmed	Role of laminin terminal globular domains in basement membrane assembly.	LAMA1 LAMC1	6.59e-05	4	116	2	17517882
Pubmed	Laminin-111 restores regenerative capacity in a mouse model for alpha7 integrin congenital myopathy.	LAMA1 LAMC1	6.59e-05	4	116	2	19074617
Pubmed	GATA6, SF1, NGFIB and DAX1 in the remodeled subcapsular zones in primary aldosteronism.	GATA6 NR5A1	6.59e-05	4	116	2	24531914
Pubmed	Oligomerization of Evi-1 regulated by the PR domain contributes to recruitment of corepressor CtBP.	CTBP1 SMAD3	6.59e-05	4	116	2	15897867
Pubmed	Groucho/transducin-like enhancer of split (TLE) family members interact with the yeast transcriptional co-repressor SSN6 and mammalian SSN6-related proteins: implications for evolutionary conservation of transcription repression mechanisms.	TLE1 TLE2	6.59e-05	4	116	2	9854018
Pubmed	SMAD3 is essential for transforming growth factor-β1-induced urokinase type plasminogen activator expression and migration in transformed keratinocytes.	PLAU SMAD3	6.59e-05	4	116	2	21798735
Pubmed	Developmental regulation of the laminin alpha5 chain suggests a role in epithelial and endothelial cell maturation.	LAMA1 LAMC1	6.59e-05	4	116	2	9299121
Cytoband	Ensembl 112 genes in cytogenetic band chr9q12	SPATA31A7 SPATA31A5	1.75e-04	8	116	2	chr9q12
GeneFamily	Protein phosphatase 6 regulatory subunits	ANKRD44 ANKRD28	2.39e-04	6	73	2	699
GeneFamily	SMAD family	SMAD3 SMAD9	4.43e-04	8	73	2	750
GeneFamily	Kinesins\|Pleckstrin homology domain containing	KIF21B KIF1B KIF1C	8.46e-04	46	73	3	622
GeneFamily	Laminin subunits	LAMA1 LAMC1	1.03e-03	12	73	2	626
ToppCell	390C-Lymphocytic-NK_cells-NK_cell_E\|390C / Donor, Lineage, Cell class and subclass (all cells)	GPR85 AFF3 XKR6 RND1 SLC49A4 PREX1	3.29e-06	155	116	6	98d8432739965dd1ab77c899cb6321f7f05eaa46
ToppCell	droplet-Liver-LIVER_HEP-30m-Myeloid-myeloid_leukocyte\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TROAP WNT6 CIITA TONSL SLX4IP FMNL1	3.68e-06	158	116	6	91d265e95156f16459924d3e4dd11c180e164eee
ToppCell	390C-Lymphocytic-CD4_T-cell-CD4+_Effector_T_cell-2\|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)	P4HA2 LAD1 XKR6 MAST2 NEDD4 ANKRD28	6.20e-06	173	116	6	b9dee61973559e8c2fef3f2dafd43475b386befb
ToppCell	control-Lymphoid-B_cell\|control / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	ADGRG5 AFF3 ANKRD44 LINC02908 CCR6 PREX1	8.02e-06	181	116	6	e414303bb90e5fe7b667c2acf9a50f8694b90e54
ToppCell	NS-control-d_0-4-Lymphoid-B_cell\|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	ADGRG5 AFF3 ANKRD44 LINC02908 CCR6 PREX1	8.28e-06	182	116	6	4b9b55154a79992112c1c467e8752c3cdbb541d9
ToppCell	COVID-19-APC-like-Dendritic_cells\|COVID-19 / group, cell type (main and fine annotations)	AFF3 ANKRD44 CIITA CCR6 PREX1 FMNL1	8.54e-06	183	116	6	703364836b42aa6ac6c68b42b700ac23c4a1afc7
ToppCell	COVID-19-APC-like\|COVID-19 / group, cell type (main and fine annotations)	AFF3 ANKRD44 CIITA CCR6 PREX1 FMNL1	8.54e-06	183	116	6	b8f5afaf9ff1b2b1bc60be58654d1b23859dafa9
ToppCell	356C-Lymphocytic-CD4_T-cell-Treg_cell_2\|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)	SESTD1 ANKS1B MAST2 TLE2 TONSL VCPIP1	9.09e-06	185	116	6	e06a784a297f357f3f8e761c24fa70722048ab42
ToppCell	Smart-seq2-blood_(Smart-seq2)-lymphocytic-B_lymphocytic-naive_B_cell\|blood_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	MYO7B AFF3 ANKRD44 CIITA TLE1 BTG1	9.66e-06	187	116	6	160e5f338537d90d50f863a1be801b1071ac7da7
ToppCell	10x_3'_v3-lymph_node_(10x_3'_v3)-lymphocytic-B_lymphocytic-naive_B_cell\|lymph_node_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	SESTD1 MYO7B AFF3 CIITA TLE1 BTG1	1.06e-05	190	116	6	441770ce7b3c81f36f5b15b8e51794f736462457
ToppCell	Smart-seq2-blood_(Smart-seq2)-lymphocytic-B_lymphocytic\|blood_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	MYO7B AFF3 ANKRD44 CIITA TLE1 BTG1	1.09e-05	191	116	6	3fc16e986aff5e0cd4f831e25e78a5b30beba7a8
ToppCell	control-Lymphoid-Treg\|Lymphoid / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	TOGARAM1 BTG1 ANKRD28 CTBP1 CCR6 FMNL1	1.23e-05	195	116	6	66959ae839eb60a573da06bdd227090ebb5bb9ed
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid-Monocytic-Monocyte-derived_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	AFF3 ANKRD44 LINC02908 CIITA PREX1 FMNL1	1.30e-05	197	116	6	826cc6baafab13e7ef5cfcf28cd79d0fbf3af38d
ToppCell	Severe-B_naive-8\|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)	MYO7B AFF3 TLE1 BTG1 MAP3K19	3.90e-05	145	116	5	a24cad86509208bc7267b02ef1d1b0a25a2a7043
ToppCell	3'_v3-bone_marrow-Lymphocytic_B-Pro-B\|bone_marrow / Manually curated celltypes from each tissue	MYO7B WNT6 AFF3 CIITA MAP3K19	5.53e-05	156	116	5	b093dbba6662e4fffc8aa577587b77f64ac44b56
ToppCell	367C-Lymphocytic-NK_cells-NK_cell_C\|367C / Donor, Lineage, Cell class and subclass (all cells)	CAPN12 ADGRG5 LINC02908 TLE1 BTG1	5.53e-05	156	116	5	a1b9e7621b646d354c2ccd850ce6a4fa9ff8a026
ToppCell	droplet-Kidney-KIDNEY-30m-Lymphocytic-Epcam____proximal_tube_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CAPN12 KIF21B NDOR1 HAUS5 CCR6	5.87e-05	158	116	5	1d78578dc1f8ba43dacdccae1082c0b9d749f64d
ToppCell	wk_20-22-Mesenchymal-Myofibro_&_SMC-Myofibro_1\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	TROAP GRM2 PTHLH TLE2 POLQ	6.23e-05	160	116	5	5cd4fbbd2ce671a8377416eff94041a111375dee
ToppCell	5'-GW_trimst-2-LymphNode-Hematopoietic-T_cells-LTi-like_NCR+_ILC3\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CAPN12 AFF3 ATP10A TLE1 CCR6	6.42e-05	161	116	5	d59713ca84aa2acadfc9b3150d5f525e1b288860
ToppCell	3'-GW_trimst-2-SmallIntestine-Hematopoietic-T_cells-ILCP\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CAPN12 ADGRG5 BTG1 CCR6 FMNL1	6.42e-05	161	116	5	6d9907e2949a742c0933128fde57832a9ca5f77c
ToppCell	Dendritic_Cells-Donor_04\|World / lung cells shred on cell class, cell subclass, sample id	ADGRG5 MYO7B LINC02908 TCFL5	7.23e-05	85	116	4	d2776a2c8d1721dbbd7d5dc868a3810e30dd9064
ToppCell	facs-Brain_Non-Myeloid-Striatum-3m-Neuronal-neuron\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	AFF3 TEKT5 SPHKAP DGKK TMEM35A	7.42e-05	166	116	5	548d0d6c0ffd564036ddba78620734220ebb73d7
ToppCell	facs-Brain_Non-Myeloid-Striatum-3m-Neuronal-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	AFF3 TEKT5 SPHKAP DGKK TMEM35A	7.42e-05	166	116	5	80e164a89d22098cabe4a99a78283ba69ea0561e
ToppCell	Dendritic_Cells-Donor_08\|World / lung cells shred on cell class, cell subclass, sample id	LINC02908 PLAU CCR6 PREX1 FMNL1	7.85e-05	168	116	5	33618e5dbcee31f30afacacc9f6046782c100fb3
ToppCell	droplet-Lung-21m-Hematologic-lymphocytic-CD8-positive,_alpha-beta_T_cell-CD8-positive,_alpha-beta_T_cell_l48\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ADGRG5 AFF3 DCLRE1C SLC49A4 CCR6	8.30e-05	170	116	5	070d8683d1a5cc7d594ff0453c961a9bf982c2d0
ToppCell	3'_v3-bone_marrow-Lymphocytic_B-ABC_aged-B_naive\|bone_marrow / Manually curated celltypes from each tissue	MYO7B AFF3 LAMC1 CIITA PLPP3	8.53e-05	171	116	5	fcc31a9a69f96de10d1324a5a4fbfe4289bf4984
ToppCell	Severe-B_naive-8\|Severe / disease group and sub_cluster of B and Plasma cells(res = 0.5)	MYO7B AFF3 TLE1 BTG1 MAP3K19	9.26e-05	174	116	5	f3f8c924420f46321bd47e2b97f18c7241541599
ToppCell	367C-Myeloid-Dendritic-cDC_proliferating_1\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	ADGRG5 TROAP HAUS5 GRM2 POLQ	9.51e-05	175	116	5	6b4e841bde6cfa4956e1a0231672cea20f11210c
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Immune-Lymphocytic_B-B_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	KIF21B AFF3 ANKRD44 CCR6 FMNL1	9.77e-05	176	116	5	274458d80f9f3f080248cbf64e4784ef351e7254
ToppCell	5'-GW_trimst-2-SmallIntestine-Hematopoietic-T_cells-ILCP\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	AFF3 XKR6 CCR6 PREX1 FMNL1	9.77e-05	176	116	5	238244294d08975df6bfa26b2b437db3654408ae
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Immune-Lymphocytic_B-B_Cell-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	KIF21B AFF3 ANKRD44 CCR6 FMNL1	9.77e-05	176	116	5	d0a3e176df1270968efa79c00dc941c5e1c4f7aa
ToppCell	390C-Lymphocytic-CD4_T-cell-CD4+_Effector_T_cell-2\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	P4HA2 LAD1 XKR6 NEDD4 ANKRD28	9.77e-05	176	116	5	437cfc5e06416bb0fc76d1f9dc106f74e279e880
ToppCell	COVID-19-lung-B_cells\|lung / Disease (COVID-19 only), tissue and cell type	ADGRG5 AFF3 XKR6 ANKRD44 CCR6	1.00e-04	177	116	5	f54691e5558091c1734ab15153a10bff15ed171e
ToppCell	systemic_lupus_erythematosus-managed-Lymphocytic_NK-T_mait-male\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	CAPN12 TLE1 BTG1 CCR6 BRD1	1.00e-04	177	116	5	605f71515c877bb4de4121675ec8c1318a2500a7
ToppCell	NS-moderate-d_16-33-Lymphoid-B_cell\|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	ADGRG5 AFF3 ANKRD44 CIITA CCR6	1.00e-04	177	116	5	320fd77c7c98e9305dcc34a168ec9d674539ed65
ToppCell	PBMC-Convalescent-Lymphocyte-B-B_cell-B_intermediate-B_intermediate-1\|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	MYO7B AFF3 CIITA TLE1 CCR6	1.03e-04	178	116	5	812e261d9cbdc74fafe3c5c3422151c1cfacb22d
ToppCell	B_cells-Naive_B_cells_\|B_cells / Immune cells in Kidney/Urine in Lupus Nephritis	MYO7B AFF3 CIITA BTG1 SMAD3	1.03e-04	178	116	5	71ac2eca5cf13a91f86b80690748b0788392dcfc
ToppCell	3'-Pediatric_IBD-SmallIntestine-Hematopoietic-B_cells-FCRL4+_Memory_B\|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ADGRG5 LIMK1 LINC02908 CCR6 PREX1	1.09e-04	180	116	5	eedb6d89680f968167afb1dcd132c9de9096b50f
ToppCell	droplet-Lung-LUNG-30m-Lymphocytic-B_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	AFF3 TG CIITA BTG1 CCR6	1.11e-04	181	116	5	46de8c18e4ec8dc9d07f7c8cc7b5f48b9c613aae
ToppCell	PBMC-Severe-Lymphocyte-B-B_cell-B_naive-B_naive-8\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	MYO7B AFF3 CIITA TLE1 BTG1	1.11e-04	181	116	5	ca34d83daca10c5fa52ecdf4eba7d31b4e7e056e
ToppCell	PBMC-Convalescent-Lymphocyte-B-B_cell-B_naive-B_naive-1\|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	SESTD1 AFF3 CIITA TLE1 CCR6	1.11e-04	181	116	5	6df40f86c569b6ecfc3137a68d1355b012dbf6bf
ToppCell	PBMC_fresh-frozen-Severe-critical_convalescent_d14-21-Lymphocytic-Lymphocytic_B-B_cell-B_c04-SOX5-TNFRSF1B\|Severe-critical_convalescent_d14-21 / Compartment, severity and other cell annotations on 10x 3' data (130k)	AFF3 PLPP3 TLE1 TLE3 CCR6	1.11e-04	181	116	5	0bc58c8942491e7ee5b858c5742770df7677532f
ToppCell	PBMC_fresh-frozen-Severe-critical_convalescent_d14-21-Lymphocytic-Lymphocytic_B-B_cell-B_c01-TCL1A\|Severe-critical_convalescent_d14-21 / Compartment, severity and other cell annotations on 10x 3' data (130k)	SESTD1 AFF3 CIITA TLE1 CCR6	1.11e-04	181	116	5	0c52dd82e6b3dce3d6bb5c13501bf8383f7121e4
ToppCell	remission-B_naive\|remission / disease stage, cell group and cell class	SESTD1 AFF3 CIITA TLE1 CCR6	1.17e-04	183	116	5	280d55d67f1d44594206da2f3a332c9d799dbdf0
ToppCell	356C-Lymphocytic-CD4_T-cell-Treg_cell_2\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	SESTD1 ANKS1B MAST2 TLE2 TONSL	1.17e-04	183	116	5	f142b320023eef00b48d4820c46214c9794d37e7
ToppCell	COVID-19-B_cells\|COVID-19 / group, cell type (main and fine annotations)	ADGRG5 ITGA6 XKR6 ANKRD28 POLQ	1.17e-04	183	116	5	2c016bb59f131a0e821853b085289a3583f0a729
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CAPN12 P4HA2 MYO7B ANKS1B D2HGDH	1.20e-04	184	116	5	9434731f651820b05335085582960f08fbf895de
ToppCell	LPS-IL1RA-Endothelial-Endothelial-Activated_Gen_Cap\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ROBO4 ITGA6 NEDD4 RND1 CIITA	1.23e-04	185	116	5	808d5e880069aff8866cd2c733b9fe568a37701f
ToppCell	CV-Moderate-7\|Moderate / Virus stimulation, Condition and Cluster	MAST2 ANKRD44 CIITA POLQ AGTPBP1	1.23e-04	185	116	5	a6c9203ce6c2892a4a369c9bcfb85720f01cbb3f
ToppCell	COVID-19-lung-B_cells\|COVID-19 / Disease (COVID-19 only), tissue and cell type	ADGRG5 AFF3 XKR6 ANKRD44 CCR6	1.23e-04	185	116	5	e8f1ad580f19705b5ca1d7d8867b2125f4891684
ToppCell	PBMC-Convalescent-Lymphocyte-B-B_cell-B_naive\|Convalescent / Location, Disease Group, Cell group, Cell class (2021.03.09)	SESTD1 AFF3 CIITA TLE1 CCR6	1.27e-04	186	116	5	f352c63666273defea3e57ba3a3bfad52c4ea65b
ToppCell	PBMC-Convalescent-Lymphocyte-B-B_cell-B_naive-\|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	SESTD1 AFF3 CIITA TLE1 CCR6	1.27e-04	186	116	5	e2d265003aaea1acaf618d3f102c9933c19102e6
ToppCell	5'-Adult-Appendix-Hematopoietic-B_cells-Memory_B\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	AFF3 ANKRD44 CIITA BTG1 CCR6	1.27e-04	186	116	5	b5e094850ac3785775393cd78a939b02339732b0
ToppCell	moderate-Lymphoid-B_cell\|moderate / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	ADGRG5 AFF3 ANKRD44 CIITA CCR6	1.27e-04	186	116	5	fd2c4c3e8929ca5d64f6c5064e5f3d3d6ba07b5f
ToppCell	CV-Moderate-7\|CV / Virus stimulation, Condition and Cluster	MAST2 ANKRD44 CIITA POLQ AGTPBP1	1.27e-04	186	116	5	8571956890fc9894d766ba294a28e376b4aba428
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CAPN12 P4HA2 MYO7B ANKS1B D2HGDH	1.27e-04	186	116	5	a417e1e21313a7e05951038cdef5ac672a9f727c
ToppCell	5'-GW_trimst-1.5-SmallIntestine-Hematopoietic-T_cells-ILCP\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ATP10A CCR6 NR5A1 PREX1 FMNL1	1.27e-04	186	116	5	428b4cbee3d3ab666cab2fc2d9c815318359e458
ToppCell	COVID-19_Convalescent-Lymphoid_B-B_naive\|COVID-19_Convalescent / Disease group, lineage and cell class	SESTD1 AFF3 CIITA TLE1 CCR6	1.27e-04	186	116	5	9d339f57036d17572882ebb801f2be9b1d1ddc1c
ToppCell	PBMC-Convalescent-Lymphocyte-B-B_cell-B_naive\|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	SESTD1 AFF3 CIITA TLE1 CCR6	1.30e-04	187	116	5	e7970ec1507adfa91a296489166142cb9400421f
ToppCell	5'-Adult-Appendix-Hematopoietic-B_cells\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	AFF3 ANKRD44 CIITA BTG1 CCR6	1.33e-04	188	116	5	7b56c680e9f1851cb961b0f8faeeb987685ae36d
ToppCell	IPF-Epithelial-ATII\|Epithelial / Disease state, Lineage and Cell class	SFTA3 CECR2 AFF3 RND1 PLPP3	1.33e-04	188	116	5	5f5fad2773e421760e67dbace23fd1f847a2e1e0
ToppCell	COPD-Endothelial-VE_Capillary_A\|Endothelial / Disease state, Lineage and Cell class	ROBO4 AFF3 XKR6 PLAU PREX1	1.33e-04	188	116	5	1aa0e35b1c28ac847886fece16c3ef7fc6fcdd51
ToppCell	metastatic_Lymph_Node-B_lymphocytes-Undetermined\|metastatic_Lymph_Node / Location, Cell class and cell subclass	ADGRG5 LIMK1 BTG1 PREX1 FMNL1	1.33e-04	188	116	5	0ddc5dbe2fd905fee20c33d9845629e259faacd9
ToppCell	NS-moderate-d_07-13-Lymphoid-B_cell\|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	ADGRG5 AFF3 ANKRD44 CIITA CCR6	1.33e-04	188	116	5	e9ed34cfea1d93eaa8e63d5b5dbb64f1520d9c4c
ToppCell	PBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Lymphocytic-Lymphocytic_B-B_cell-B_c01-TCL1A\|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)	SESTD1 AFF3 LAMC1 CIITA TLE1	1.40e-04	190	116	5	112706d64ee73b55dcf76f33ca064ab1fc6ce87f
ToppCell	3'_v3-bone_marrow-Lymphocytic_B-Naive_B_cells\|bone_marrow / Manually curated celltypes from each tissue	MYO7B CECR2 AFF3 CIITA TLE1	1.40e-04	190	116	5	3d45d5011305f13634013d9eeb98f235517dd54e
ToppCell	severe-B_naive\|World / disease stage, cell group and cell class	AFF3 CIITA TLE1 BTG1 CCR6	1.40e-04	190	116	5	8dfe067d75573289299a5fba42b6c9b26e5fb430
ToppCell	10x_3'_v3-tissue-resident_(10x_3'_v3)-lymphocytic-B_lymphocytic-naive_B_cell\|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	MYO7B AFF3 ANKRD44 TLE1 BTG1	1.40e-04	190	116	5	a7498fe55b7810c482291db782dc5282675d246a
ToppCell	severe-B_naive\|severe / disease stage, cell group and cell class	AFF3 CIITA TLE1 BTG1 CCR6	1.40e-04	190	116	5	2430a1fd18385305bf1b604747ff64026a8d5edf
ToppCell	PBMC-Mild-Lymphocyte-B-B_cell-B_naive-B_activate-7\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	AFF3 CIITA TLE1 CCR6 HERC5	1.43e-04	191	116	5	2feab42ac6d29fa4eac78f3f78a5f8aa0a559523
ToppCell	PBMC-Severe-Lymphocyte-B-B_cell-B_intermediate-B_intermediate-0\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	AFF3 CIITA TLE1 BTG1 CCR6	1.43e-04	191	116	5	b7d17d3ba488378b30f3732f8109f4a7c1673e61
ToppCell	LPS_only-Endothelial-Endothelial-Activated_Alv_Cap\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ROBO4 AFF3 NEDD4 RND1 CIITA	1.43e-04	191	116	5	a7b18bcf27c38ad2353c239ecb309c80f3ef3359
ToppCell	COVID-19_Convalescent-Lymphoid_B-B_memory\|COVID-19_Convalescent / Disease group, lineage and cell class	AFF3 CIITA TLE1 TLE3 CCR6	1.43e-04	191	116	5	4a853cd2434b0f5b18e1f853c37515845046c88b
ToppCell	PBMC-Convalescent-Lymphocyte-B-B_cell\|Convalescent / Location, Disease Group, Cell group, Cell class (2021.03.09)	AFF3 CIITA PLPP3 TLE1 CCR6	1.43e-04	191	116	5	07b03739db24c7d834300de63ef1847724cba684
ToppCell	10x5'-bone_marrow-Lymphocytic_B-Naive_B_cells\|bone_marrow / Manually curated celltypes from each tissue	SESTD1 MYO7B AFF3 CIITA BTG1	1.47e-04	192	116	5	fa99243ff028498c6a67d207a93e02c48e69cd42
ToppCell	3'-Distal_airway-Immune_Lymphocytic-Lymphocytic_T/NK-natural_killer_cell-NK_cells-NK_cells_L.1.3.0.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ADGRG5 TLE1 BTG1 DGKK FMNL1	1.47e-04	192	116	5	1922b0350d3375e67c314dbce8074e5cf986f2ef
ToppCell	3'-Distal_airway-Immune_Lymphocytic-Lymphocytic_T/NK-natural_killer_cell\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ADGRG5 TLE1 BTG1 DGKK FMNL1	1.47e-04	192	116	5	97c197643e59835c6d45dde9e549c9a1b1bb7288
ToppCell	PBMC-Convalescent-Lymphocyte-B-B_cell\|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	AFF3 CIITA PLPP3 TLE1 CCR6	1.47e-04	192	116	5	ee309564ac6136c1dc314d5cd3603687ee2266f2
ToppCell	3'-Distal_airway-Immune_Lymphocytic-Lymphocytic_T/NK-natural_killer_cell-NK_cells\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ADGRG5 TLE1 BTG1 DGKK FMNL1	1.47e-04	192	116	5	a4d161e3d48bc020e687808b352325ef9d1cc1f3
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid-Monocytic-Monocyte-derived_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	AFF3 ANKRD44 CIITA PREX1 FMNL1	1.50e-04	193	116	5	3e3d7cb3e7242ec9c9677e07e303835649852b52
ToppCell	11.5-Airway-Immune-Hematopoietic,_T_Cells\|Airway / Age, Tissue, Lineage and Cell class	ADGRG5 ATP10A CCR6 PREX1 FMNL1	1.50e-04	193	116	5	7c14bc481ed38378b9e6a85f768a1e526c5997e6
ToppCell	PBMC-Convalescent-Lymphocyte-B-B_cell-B_intermediate-\|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	AFF3 CIITA PLPP3 TLE1 CCR6	1.50e-04	193	116	5	437ae3b10d169bb371f7b92d57a77f43e3f8d64d
ToppCell	COVID-19_Convalescent-Lymphoid_B\|COVID-19_Convalescent / Disease group, lineage and cell class	AFF3 CIITA PLPP3 TLE1 CCR6	1.50e-04	193	116	5	e0973f3f3ae8ddcb6e22af5eb1e0fe6fe607a20b
ToppCell	PBMC-Convalescent-Lymphocyte-B-B_cell-B_intermediate\|Convalescent / Location, Disease Group, Cell group, Cell class (2021.03.09)	AFF3 CIITA PLPP3 TLE1 CCR6	1.50e-04	193	116	5	94b5a4a4e9faaa95cb72907a2f0497429c72e516
ToppCell	PBMC-Convalescent-Lymphocyte-B-B_cell-B_intermediate\|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	AFF3 CIITA PLPP3 TLE1 CCR6	1.50e-04	193	116	5	2416b39e18ce0c7016c2351f79bf1b2ecc183a98
ToppCell	RV-02._Fibroblast_II\|RV / Chamber and Cluster_Paper	SESTD1 ANKS1B LAMC1 ANKRD44 SMAD3	1.54e-04	194	116	5	11c79a8c56ece42713b04b321982e41e239f07a5
ToppCell	Smart-seq2-lymph_node_(Smart-seq2)-lymphocytic-B_lymphocytic-B_cell\|lymph_node_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	MYO7B AFF3 ANKRD44 CIITA BTG1	1.54e-04	194	116	5	ff661419b697aef51a53fdeac8d37d870d65f491
ToppCell	COVID-19_Moderate-B_naive\|COVID-19_Moderate / disease group, cell group and cell class	AFF3 CIITA TLE1 BTG1 CCR6	1.54e-04	194	116	5	8c41a37467bfd4966ecd09dde68c543dc01b6ad0
ToppCell	367C-Lymphocytic-NK_cells\|367C / Donor, Lineage, Cell class and subclass (all cells)	CAPN12 ADGRG5 TLE1 BTG1 DGKK	1.54e-04	194	116	5	2e447de50b3f4b59e3b9928df83879955fed93cc
ToppCell	10x_3'_v3-thymus_(10x_3'_v3)-lymphocytic-B_lymphocytic-memory_B_cell\|thymus_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	SESTD1 AFF3 CIITA TLE1 TLE3	1.54e-04	194	116	5	f0c113edb706d53792892115b67277a285219942
ToppCell	COPD-Endothelial-VE_Peribronchial\|Endothelial / Disease state, Lineage and Cell class	RND1 KCNB1 PLPP3 ANKRD28 SMAD3	1.54e-04	194	116	5	8dcde77767b23e75360adb316cdccf56a00e3726
ToppCell	IPF-Endothelial-VE_Capillary_A\|Endothelial / Disease state, Lineage and Cell class	ROBO4 AFF3 XKR6 PLAU PREX1	1.54e-04	194	116	5	777ce41c3f22c591e2d81120f189b834e53ffb4b
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Vascular-Mural_cell-Scavenging_endothelial-G\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	ROBO4 GPR85 ITGA6 LAMC1 ATP10A	1.54e-04	194	116	5	ea5e1bc8d9e27cabfe1fb833ca47ec0893593b12
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Vascular-Mural_cell-Scavenging_endothelial\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	ROBO4 GPR85 ITGA6 LAMC1 ATP10A	1.54e-04	194	116	5	cceb7c88492bb6cd531e1c2651638da1ddf30931
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ROBO4 CIITA PLPP3 PREX1 SMAD9	1.54e-04	194	116	5	e55dc30e200c9f576804acb642175eb4fa9146b5
ToppCell	LPS_only-Endothelial-Endothelial-Activated_Gen_Cap\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ROBO4 ITGA6 NEDD4 RND1 CIITA	1.58e-04	195	116	5	56efeb58df19f357d7d5ce87348d4f196a595421
ToppCell	COVID-19_Convalescent-Lymphoid_B-B_intermediate\|COVID-19_Convalescent / Disease group, lineage and cell class	AFF3 CIITA PLPP3 TLE1 CCR6	1.58e-04	195	116	5	b213f19dad4c8d5a6bf20cadb1135fb2bb0b40ee
ToppCell	5'-GW_trimst-2-SmallIntestine-Hematopoietic-T_cells-LTi-like_NCR+_ILC3\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	AFF3 ATP10A BTG1 CCR6 FMNL1	1.58e-04	195	116	5	69201b1172bcf0999c726516e4d30863afceab0b
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Immune\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	AFF3 ANKRD44 CIITA PREX1 FMNL1	1.58e-04	195	116	5	7b6c69df943842b566a596e30bb50dbe80dccc83
ToppCell	remission-B_intermediate\|remission / disease stage, cell group and cell class	AFF3 CIITA PLPP3 TLE1 CCR6	1.58e-04	195	116	5	ee14d00eb5800fadd57c2304e9461534d8668674
Disease	autosomal recessive nonsyndromic deafness 16 (implicated_via_orthology)	STRC STRCP1	1.35e-05	2	109	2	DOID:0110471 (implicated_via_orthology)
Disease	chronic obstructive pulmonary disease (implicated_via_orthology)	PLAU MUC5AC	4.05e-05	3	109	2	DOID:3083 (implicated_via_orthology)
Disease	serum non-albumin protein measurement	EXOC6 AFF3 XKR6 MAST2 TLE3 CCR6 SMAD3 MAP3K19	6.03e-05	361	109	8	EFO_0004568
Disease	asthma, seasonal allergic rhinitis	XKR6 PTHLH SMAD3	2.25e-04	32	109	3	EFO_0003956, MONDO_0004979
Disease	docosahexaenoic acid measurement, sex interaction measurement	GATA6 LRRC30	2.81e-04	7	109	2	EFO_0007761, EFO_0008343
Disease	prostate cancer (is_marker_for)	XIAP PLAU PREX1 SMAD3 SMAD9	2.91e-04	156	109	5	DOID:10283 (is_marker_for)
Disease	Rheumatoid Arthritis	AFF3 ITGA6 CIITA TLE3 CCR6	4.79e-04	174	109	5	C0003873
Disease	cancer antigen 125 measurement	GAL3ST3 D2HGDH	5.97e-04	10	109	2	EFO_0010603
Disease	Amyotrophic Lateral Sclerosis, Sporadic	SHC1 XIAP TLE3	7.51e-04	48	109	3	C1862941
Disease	Amyotrophic Lateral Sclerosis, Familial	SHC1 XIAP TLE3	7.51e-04	48	109	3	C4551993
Disease	AMYOTROPHIC LATERAL SCLEROSIS 1	SHC1 XIAP TLE3	8.47e-04	50	109	3	C1862939
Disease	nervous system disease (implicated_via_orthology)	KIF1B KIF1C	8.71e-04	12	109	2	DOID:863 (implicated_via_orthology)
Disease	polyp of colon	PREX1 SMAD3 SMAD9	1.18e-03	56	109	3	MONDO_0021400
Disease	caffeine measurement	LAMC1 PTHLH	1.38e-03	15	109	2	EFO_0021177
Disease	2-hydroxyglutarate measurement	GAL3ST3 D2HGDH	1.57e-03	16	109	2	EFO_0021506
Disease	lifestyle measurement	P4HA2 AFF3 XKR6 PREX1 ERCC6L2-AS1	1.83e-03	235	109	5	EFO_0010724
Disease	keratoconus	SMAD3 MAP3K19 KIF1C	1.89e-03	66	109	3	MONDO_0015486
Disease	colorectal cancer, colorectal adenoma	LAMC1 PREX1 SMAD3 SMAD9	2.48e-03	152	109	4	EFO_0005406, MONDO_0005575
Disease	asthma, endometriosis	XKR6 SMAD3 XPOT	2.63e-03	74	109	3	EFO_0001065, MONDO_0004979

Protein segments in the cluster

Peptide	Gene	Start	Entry
TCEKRRTRGLSRIVP	AFF3	646	P51826
LETLLQPRKRSRSTC	BRD1	791	O95696
AVSSRGTPILILKRC	BPIFB3	146	P59826
GDERTLRRTSLCLKG	ARID4A	96	P29374
RRAITGRIPDSLKNC	CTBP1	336	Q13363
PESASCLLRLRNKLR	CTC1	206	Q2NKJ3
KLLRGCTLLLTARPR	CIITA	536	P33076
KRCARLLTRLAVSPL	ALKAL1	111	Q6UXT8
KPSTAVCTLRRLGLG	GRM2	626	Q14416
LRSRTLPRSKIICLV	CCR6	156	P51684
KCLLRDSRGRTPIHL	ANKRD28	711	O15084
ESGEIRTLKPCLLRR	DFFA	11	O00273
VVSCGSRAVPRKLRT	FAM187A	211	A6NFU0
CVGLLRLKRLTSPLE	AGTPBP1	1131	Q9UPW5
SEKLLCPRGRTLQET	CECR2	1096	Q9BXF3
KLACTPSLIRAGSRV	ATP5MC3	6	P48201
LARQLTRKSPRRCSA	ATP10A	1306	O60312
CSRPIRIGLSRKARI	RAD51AP2	1126	Q09MP3
ERACTLGRIRSLPKA	ANKS1B	711	Q7Z6G8
GPILSIRICRDKITR	PABPC1L2A	26	Q5JQF8
IICTVLRIPSAAGKR	OR6N1	221	Q8NGY5
LLQCPVDTRERGLKT	DGKK	181	Q5KSL6
RRSESVKSRGLPCTE	LAD1	416	O00515
GSRVPRIKSQTIACR	NAXE	16	Q8NCW5
TILLRPTCKEVVSRG	METAP2	461	P50579
LRLSKTICTPGEVRD	NEDD4	326	P46934
PLLAGTIRSKLSRRC	KIF1B	1796	O60333
RVLRCLPGRNRKEST	ECPAS	536	Q5VYK3
CLPRRVLAIKGRATT	KIF21B	1621	O75037
CERVRDLLNPKSRGS	KIF1C	151	O43896
VKEGRVPCRTLRTEL	MIGA2	326	Q7L4E1
SGEKICRRPEEITRL	MUC5AC	1776	P98088
SGEKICRRPEEITRL	MUC5AC	3986	P98088
EVSILCKDSRGRTPL	ANKRD44	726	Q8N8A2
IRCPLRGLDSKASLI	ITGA6	976	P23229
AETGARTSLPKERCR	KLLN	111	B2CW77
KTRLCRSPGEVLALV	HAUS5	411	O94927
TRTLSSCLLNLIRKP	EXOC6	526	Q8TAG9
FQTRLKEPRRGLCSS	NDOR1	406	Q9UHB4
ESLCRGEGVKLTPRR	P4HA2	291	O15460
SPACLTGSFLRKRRT	HERC5	421	Q9UII4
RLARCPSPKLLRARS	FAM189B	536	P81408
SRRKILLLVLGCSTV	GAL3ST3	16	Q96A11
QKRVPSSRRLGLSCA	GATA6	431	Q92908
ARGGRTPKCTVLLSL	CAPN12	416	Q6ZSI9
RLPRTRLGKLRDCNT	KCNB1	51	Q14721
GLRAPTLKRRLECSL	DCLRE1C	41	Q96SD1
VACGARLRRSLKPQS	DNASE1L2	251	Q92874
SKLRPRGQCRLEFSL	GBA2	396	Q9HCG7
LRRKTLLPKRTACPT	FBXO11	101	Q86XK2
SSCRKEAVLPRLRVT	LINC02908	61	Q6ZV77
TGLRCIPISDLILKR	SLC49A4	131	Q96SL1
RLAKRCSPSSLGLRR	ERCC6L2-AS1	56	Q8WZB0
SLKPVRSCLQRREGE	POLQ	511	O75417
DSRACSPALRALLRK	GPAT2	231	Q6NUI2
LKELSLPRRGSFCRT	MAST2	156	Q6P0Q8
PFTARTGKRTSRLLC	FMNL1	1076	O95466
STTLLYCRKSRLPRE	GPR85	351	P60893
IRNLEDIRKTLPSGC	LAMC1	1586	P11047
RTLSPGILGRLCLKE	DALRD3	206	Q5D0E6
SLRSRKARPDLERIC	SAMD1	41	Q6SPF0
REICSAPSGRRITNK	MAP3K19	686	Q56UN5
LRGCSKVLLRPRTSE	D2HGDH	96	Q8N465
LCGNRLKSLPREVSL	LRRC30	101	A6NM36
TRQTLGREPKSFLCR	KCTD2	86	Q14681
LSPPCKSRLARRRAL	MKNK1	436	Q9BUB5
VETRGPLCSLRSEKR	SENP2	276	Q9HC62
GECPAVLSKETIRRR	SPHKAP	731	Q2M3C7
RARILGCLQEPTKSR	NR5A1	241	Q13285
IRSKEGRCAQPSRTI	PLAU	281	P00749
PRRSGSKRVLLICLD	PLPP3	26	O14495
PSTRVLLIGCKTDLR	RND1	116	Q92730
GVRKGCLLEPIRSVS	LAMA1	2476	P25391
CGIRDSKLRVILPAL	PRAMEF22	361	A3QJZ6
RKPLRSDSGSDLLRC	SPATA31A7	706	Q8IWB4
LTCTTALPGSSKRRR	PHF12	231	Q96QT6
SFCSRRPLRLLVATK	PREX1	691	Q8TCU6
LRRDPSVKRTLCRGC	RPP21	51	Q9H633
GPLKVAQTRLECRTR	TEKT5	386	Q96M29
RRGLDPTGTVILLCK	SKIV2L	706	Q15477
SNRRLVKRLCAGLLP	STRC	436	Q7RTU9
LRATLKRPEVIATCG	ROBO4	461	Q8WZ75
ERLKTGLLSRSPVCS	SLX4IP	261	Q5VYV7
SKCVTIPRSLDGRLQ	SMAD9	66	O15198
KDRRSGLILTIPLCL	SESTD1	21	Q86VW0
RISCKEELLLGRTSP	BTG1	146	P62324
ELTRDACKTRPRELR	ADGRG5	116	Q8IZF4
RKPLRSDSGSDLLRC	SPATA31A3	706	Q5VYP0
SACLRSLLGRKPRRS	XKR6	71	Q5GH73
SLLVPDSLRGTDKRR	TLE1	201	Q04724
ARPSGLLAQERKLCR	THRAP3	581	Q9Y2W1
IGRLCREILRITDPK	WASHC5	821	Q12768
CLVRTTEKTPSLTRR	XIAP	351	P98170
RKPLRSDSGSDLLRC	SPATA31A1	706	Q5TZJ5
RKPLRSDSGSDLLRC	SPATA31A5	706	Q5VU36
ETSLGRLSCVTKRRP	TMEM94	666	Q12767
NTKCITIPRSLDGRL	SMAD3	61	P84022
TCGLLPRLTLRKEGA	TONSL	971	Q96HA7
PRTLALRERLKSCLT	TROAP	706	Q12815
DPTSICRKARRLAGR	WNT6	36	Q9Y6F9
LLKRRDRRILSGSCP	VCPIP1	36	Q96JH7
PSCGRSVEGLSRRLK	PTHLH	21	P12272
RSCKLLPDGRTLIVG	TLE3	536	Q04726
LSCPLQKDILRSGVR	XPOT	691	O43592
STTLCLREREKRIPT	SFTA3	41	P0C7M3
SNRRLVKRLCAGLLP	STRCP1	436	A6NGW2
CLKRSPGEVLRTLIQ	TOGARAM1	206	Q9Y4F4
LRRLCKTVGATALPR	CCT8	321	P50990
GRRLKLTRPDSLVTC	TCFL5	471	Q9UL49
IRSCKLLPDGRSLIV	TLE2	506	Q04725
PSLCNVLKSGVLSRR	TG	1146	P01266
TRRRKPCSRPLSSIL	SHC1	206	P29353
CLLKQESRGRRLSPQ	nan	321	Q8N7P7
KTVGRIKLDCSLRPS	TTC31	6	Q49AM3
KLLCGSLTRLLDSVR	GEMIN4	941	P57678
CPETIKSLLIRRGLQ	LDAH	201	Q9H6V9
RSRSCNIRLIGIPEK	L1TD1	696	Q5T7N2
KDLGRSESLRVVCRP	LIMK1	316	P53667
TCRLLIARKPEDRSS	TMEM35A	126	Q53FP2
DTRRGKLLAPDCSRR	MYO7B	1756	Q6PIF6
DCSRRIQKVLRTGPR	MYO7B	1766	Q6PIF6