Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionRNA polymerase II transcription regulatory region sequence-specific DNA binding

ZNF823 ZHX3 ZBED2 ZNF589 GATA2 WT1 POU3F2 CHD7 FOXA2 ZNF784 EN2 KDM6A ZNF446 HSF5 ZIC3 HOXA1 ZNF646

3.54e-0614596617GO:0000977
GeneOntologyMolecularFunctionDNA-binding transcription factor activity, RNA polymerase II-specific

ZNF823 ZHX3 ZBED2 ZNF589 GATA2 WT1 GSX2 POU3F2 FOXA2 ZNF784 EN2 ZNF446 ZIC3 HOXA1 ZNF646

4.44e-0514126615GO:0000981
GeneOntologyMolecularFunctionchromatin binding

TRIM33 CCNT2 NCOA6 TLE1 GATA2 CHD7 MBD5 ARID1A FOXA2 KDM6A

1.47e-047396610GO:0003682
GeneOntologyMolecularFunctionRNA polymerase II cis-regulatory region sequence-specific DNA binding

GATA2 WT1 POU3F2 CHD7 FOXA2 ZNF784 EN2 KDM6A ZNF446 HSF5 ZIC3 HOXA1 ZNF646

1.85e-0412446613GO:0000978
GeneOntologyMolecularFunctioncis-regulatory region sequence-specific DNA binding

GATA2 WT1 POU3F2 CHD7 FOXA2 ZNF784 EN2 KDM6A ZNF446 HSF5 ZIC3 HOXA1 ZNF646

2.28e-0412716613GO:0000987
GeneOntologyMolecularFunctionATP-dependent chromatin remodeler activity

CECR2 CHD7 ARID1A

2.47e-0437663GO:0140658
GeneOntologyMolecularFunctionzinc ion binding

TRIM33 PRDM9 ATP7B UBR5 ZNF589 MARCHF6 GATA2 WT1 TAB2 TNKS

6.49e-048916610GO:0008270
GeneOntologyMolecularFunctionco-SMAD binding

TRIM33 USP9Y

6.95e-0412662GO:0070410
GeneOntologyMolecularFunctionATP-dependent activity, acting on DNA

G3BP1 CECR2 CHD7 ARID1A

8.29e-04127664GO:0008094
GeneOntologyMolecularFunctionC2H2 zinc finger domain binding

GATA2 WT1

1.42e-0317662GO:0070742
GeneOntologyBiologicalProcesspositive regulation of transcription by RNA polymerase II

CCNT2 NCOA6 PRDM9 CAND1 ZNF827 ZBED2 GATA2 WT1 POU3F2 TNKS CHD7 FOXA2 ZNF784 EN2 KDM6A CDON ZIC3 HOXA1 ZNF646

4.01e-0813906619GO:0045944
GeneOntologyBiologicalProcesssemicircular canal development

GATA2 CHD7 HOXA1

5.07e-0611663GO:0060872
GeneOntologyBiologicalProcessanterior/posterior pattern specification

ROR2 WT1 FOXA2 KDM6A CDON ZIC3 HOXA1

1.38e-05247667GO:0009952
GeneOntologyBiologicalProcessembryonic morphogenesis

AMOT CECR2 ROR2 GATA2 CHD7 ARID1A FOXA2 KDM6A CDON ZIC3 HOXA1

1.48e-057136611GO:0048598
GeneOntologyBiologicalProcessbrain development

NCOA6 ATXN2 GATA2 GSX2 POU3F2 CHD7 ARID1A FOXA2 EN2 CDON ZIC3 HOXA1

1.56e-058596612GO:0007420
GeneOntologyBiologicalProcesssmoothened signaling pathway

UBR5 ROR2 ARMC9 FOXA2 CDON ZIC3

2.11e-05176666GO:0007224
GeneOntologyBiologicalProcesshead development

NCOA6 ATXN2 GATA2 GSX2 POU3F2 CHD7 ARID1A FOXA2 EN2 CDON ZIC3 HOXA1

3.04e-059196612GO:0060322
GeneOntologyBiologicalProcessembryo development

NCOA6 AMOT CECR2 ZBED2 ROR2 GATA2 WT1 CHD7 ARID1A FOXA2 EN2 KDM6A CDON ZIC3 HOXA1

3.75e-0514376615GO:0009790
GeneOntologyBiologicalProcesssegmentation

ROR2 WT1 FOXA2 KDM6A ZIC3

4.64e-05123665GO:0035282
GeneOntologyBiologicalProcesshindbrain development

ATXN2 GATA2 GSX2 FOXA2 EN2 HOXA1

5.37e-05208666GO:0030902
GeneOntologyBiologicalProcessanatomical structure formation involved in morphogenesis

MFSD14A PXDN ATXN2 AMOT CECR2 ERVFC1 ROR2 GATA2 WT1 ARID1A FOXA2 KDM6A CDON ZIC3 HOXA1

5.39e-0514836615GO:0048646
GeneOntologyBiologicalProcessanterior/posterior axis specification

WT1 FOXA2 KDM6A ZIC3

6.68e-0568664GO:0009948
GeneOntologyBiologicalProcessembryonic organ development

NCOA6 ROR2 GATA2 CHD7 ARID1A EN2 KDM6A ZIC3 HOXA1

7.11e-05561669GO:0048568
GeneOntologyBiologicalProcesspositive regulation of embryonic development

AMOT ZBED2 FOXA2

8.66e-0527663GO:0040019
GeneOntologyBiologicalProcesscentral nervous system development

NCOA6 ATXN2 ROR2 GATA2 GSX2 POU3F2 CHD7 ARID1A FOXA2 EN2 CDON ZIC3 HOXA1

9.11e-0511976613GO:0007417
GeneOntologyBiologicalProcesscell fate commitment

ROR2 GATA2 WT1 GSX2 POU3F2 FOXA2 CDON

1.01e-04338667GO:0045165
GeneOntologyBiologicalProcesssensory organ development

PXDN CECR2 ROR2 GATA2 WT1 CHD7 ARID1A CDON ZIC3 HOXA1

1.02e-047306610GO:0007423
GeneOntologyBiologicalProcesssensory organ morphogenesis

ROR2 GATA2 CHD7 ARID1A CDON ZIC3 HOXA1

1.11e-04343667GO:0090596
GeneOntologyBiologicalProcessembryonic organ morphogenesis

ROR2 GATA2 CHD7 ARID1A KDM6A ZIC3 HOXA1

1.28e-04351667GO:0048562
GeneOntologyBiologicalProcesschordate embryonic development

NCOA6 AMOT CECR2 ROR2 GATA2 CHD7 ARID1A FOXA2 KDM6A ZIC3 HOXA1

1.30e-049066611GO:0043009
GeneOntologyBiologicalProcessear morphogenesis

ROR2 GATA2 CHD7 ZIC3 HOXA1

1.35e-04154665GO:0042471
GeneOntologyBiologicalProcessregionalization

ROR2 WT1 GSX2 FOXA2 KDM6A CDON ZIC3 HOXA1

1.39e-04478668GO:0003002
GeneOntologyBiologicalProcessmulticellular organism growth

ATXN2 CTC1 POU3F2 CHD7 MBD5 KDM6A

1.45e-04249666GO:0035264
GeneOntologyBiologicalProcessprotein localization to chromosome, telomeric region

GNL3L ZNF827 TNKS

1.45e-0432663GO:0070198
GeneOntologyBiologicalProcesscell differentiation in hindbrain

ATXN2 GATA2 FOXA2

1.45e-0432663GO:0021533
GeneOntologyBiologicalProcessnegative regulation of telomere maintenance via telomere lengthening

GNL3L CTC1 TNKS

1.59e-0433663GO:1904357
GeneOntologyBiologicalProcessembryo development ending in birth or egg hatching

NCOA6 AMOT CECR2 ROR2 GATA2 CHD7 ARID1A FOXA2 KDM6A ZIC3 HOXA1

1.62e-049296611GO:0009792
GeneOntologyBiologicalProcessgastrulation with mouth forming second

AMOT FOXA2 ZIC3

1.90e-0435663GO:0001702
GeneOntologyBiologicalProcessembryonic pattern specification

WT1 FOXA2 KDM6A ZIC3

2.07e-0491664GO:0009880
GeneOntologyBiologicalProcessneuron fate commitment

GATA2 GSX2 POU3F2 FOXA2

2.07e-0491664GO:0048663
GeneOntologyBiologicalProcessregulation of multicellular organism growth

ATXN2 POU3F2 CHD7 MBD5

2.25e-0493664GO:0040014
GeneOntologyBiologicalProcesspattern specification process

ROR2 WT1 GSX2 FOXA2 KDM6A CDON ZIC3 HOXA1

2.66e-04526668GO:0007389
GeneOntologyBiologicalProcessear development

CECR2 ROR2 GATA2 CHD7 ZIC3 HOXA1

2.99e-04285666GO:0043583
GeneOntologyBiologicalProcessregulation of canonical Wnt signaling pathway

G3BP1 UBR5 TLE1 ZBED2 ROR2 TNKS

2.99e-04285666GO:0060828
GeneOntologyBiologicalProcessnegative regulation of telomere maintenance

GNL3L CTC1 TNKS

3.29e-0442663GO:0032205
GeneOntologyBiologicalProcessneuron fate specification

GSX2 POU3F2 FOXA2

3.29e-0442663GO:0048665
GeneOntologyBiologicalProcesssemicircular canal morphogenesis

CHD7 HOXA1

3.58e-049662GO:0048752
GeneOntologyBiologicalProcessouter ear morphogenesis

ZIC3 HOXA1

4.46e-0410662GO:0042473
GeneOntologyBiologicalProcessaxis specification

WT1 FOXA2 KDM6A ZIC3

4.74e-04113664GO:0009798
GeneOntologyBiologicalProcessgastrulation

AMOT ARID1A FOXA2 KDM6A ZIC3

5.88e-04212665GO:0007369
GeneOntologyBiologicalProcesspositive regulation of canonical Wnt signaling pathway

UBR5 ZBED2 ROR2 TNKS

6.13e-04121664GO:0090263
GeneOntologyBiologicalProcessembryonic axis specification

WT1 FOXA2 KDM6A

6.18e-0452663GO:0000578
GeneOntologyBiologicalProcessanimal organ morphogenesis

TLE1 ROR2 GATA2 WT1 GSX2 CHD7 ARID1A FOXA2 KDM6A CDON ZIC3 HOXA1

6.23e-0412696612GO:0009887
GeneOntologyBiologicalProcesscell fate specification

GSX2 POU3F2 FOXA2 CDON

6.52e-04123664GO:0001708
GeneOntologyBiologicalProcessolfactory bulb development

GSX2 CHD7 ZIC3

6.54e-0453663GO:0021772
GeneOntologyBiologicalProcessgenitalia development

ROR2 WT1 CHD7

6.91e-0454663GO:0048806
GeneOntologyBiologicalProcessolfactory lobe development

GSX2 CHD7 ZIC3

7.68e-0456663GO:0021988
GeneOntologyBiologicalProcessprimitive streak formation

FOXA2 ZIC3

7.69e-0413662GO:0090009
GeneOntologyBiologicalProcessinner ear morphogenesis

ROR2 GATA2 CHD7 HOXA1

7.80e-04129664GO:0042472
GeneOntologyBiologicalProcesscanonical Wnt signaling pathway

G3BP1 UBR5 TLE1 ZBED2 ROR2 TNKS

8.07e-04344666GO:0060070
GeneOntologyBiologicalProcesstube morphogenesis

PXDN AMOT CECR2 GATA2 WT1 CHD7 ARID1A FOXA2 KDM6A ZIC3 HOXA1

8.20e-0411256611GO:0035239
GeneOntologyBiologicalProcesssomite rostral/caudal axis specification

FOXA2 KDM6A

8.95e-0414662GO:0032525
GeneOntologyBiologicalProcessforebrain development

GATA2 GSX2 POU3F2 CHD7 ARID1A CDON ZIC3

9.39e-04489667GO:0030900
GeneOntologyBiologicalProcessregulation of telomere maintenance via telomerase

GNL3L CTC1 TNKS

9.40e-0460663GO:0032210
GeneOntologyBiologicalProcesscochlea development

CECR2 GATA2 HOXA1

9.86e-0461663GO:0090102
GeneOntologyBiologicalProcessskeletal muscle satellite cell differentiation

MSTN CDON

1.03e-0315662GO:0014816
GeneOntologyBiologicalProcessregulation of Wnt signaling pathway

G3BP1 UBR5 TLE1 ZBED2 ROR2 TNKS

1.14e-03368666GO:0030111
GeneOntologyBiologicalProcessneuroendocrine cell differentiation

GATA2 POU3F2

1.18e-0316662GO:0061101
GeneOntologyBiologicalProcessprotein-DNA complex organization

PRDM9 CAND1 UBR5 ZNF827 CECR2 WT1 CHD7 ARID1A FOXA2 KDM6A

1.21e-039996610GO:0071824
GeneOntologyBiologicalProcessinner ear development

CECR2 ROR2 GATA2 CHD7 HOXA1

1.30e-03253665GO:0048839
GeneOntologyBiologicalProcessregulation of telomere maintenance via telomere lengthening

GNL3L CTC1 TNKS

1.41e-0369663GO:1904356
GeneOntologyBiologicalProcesspositive regulation of Wnt signaling pathway

UBR5 ZBED2 ROR2 TNKS

1.65e-03158664GO:0030177
GeneOntologyCellularComponentchromatin

TRIM33 ZHX3 PRDM9 UBR5 ZNF827 CECR2 ZBED2 GSX2 POU3F2 CHD7 ARID1A FOXA2 EN2 ZNF446 HOXA1

4.51e-0514806615GO:0000785
HumanPhenoTetralogy of Fallot

ROR2 WT1 TAB2 CHD7 ARID1A KDM6A CDON

3.56e-05185277HP:0001636
HumanPhenoComplex cardiac malformations

ROR2 WT1 TAB2 CHD7 ARID1A KDM6A CDON ZIC3

3.62e-05257278HP:0002565
HumanPhenoConotruncal defect

ROR2 WT1 TAB2 CHD7 ARID1A KDM6A CDON ZIC3

4.39e-05264278HP:0001710
HumanPhenoAbnormal ventriculoarterial connection

ROR2 WT1 TAB2 CHD7 ARID1A KDM6A CDON ZIC3

6.69e-05280278HP:0011563
HumanPhenoAbnormal connection of the cardiac segments

ROR2 WT1 TAB2 CHD7 ARID1A KDM6A CDON ZIC3

7.41e-05284278HP:0011545
MousePhenoabnormal cerebellum vermis lobule morphology

CHD7 EN2 ZIC3

2.84e-068533MP:0009957
MousePhenoabnormal cerebellar hemisphere morphology

CHD7 EN2 ZIC3

4.25e-069533MP:0009959
MousePhenoperinatal lethality

JPH1 NCOA6 G3BP1 CECR2 ROR2 CPEB4 GATA2 WT1 GSX2 MBD5 ARID1A FOXA2 KDM6A CDON HOXA1

1.25e-0511305315MP:0002081
MousePhenoabnormal cerebellum hemisphere lobule morphology

CHD7 EN2

4.22e-053532MP:0009963
MousePhenoabnormal developmental patterning

TRIM33 G3BP1 UBR5 AMOT ROR2 CHD7 ARID1A FOXA2 KDM6A ZIC3

5.21e-055775310MP:0002084
MousePhenoreduced fertility

NCOA6 PRDM9 ATP7B ATXN2 ZBED2 ROR2 WT1 NRG2 CHD7 FOXA2 EN2 ZIC3

5.81e-058445312MP:0001921
MousePhenoabnormal vestibular nerve morphology

CHD7 HOXA1

8.42e-054532MP:0004718
MousePhenodecreased total retina thickness

CCNT2 G3BP1 TLE1 TNKS MBD5 DUSP11

9.60e-05197536MP:0011965
MousePhenoperinatal lethality, incomplete penetrance

NCOA6 CECR2 CPEB4 GATA2 MBD5 FOXA2 KDM6A CDON HOXA1

1.02e-04503539MP:0011090
MousePhenoembryonic growth retardation

TRIM33 NCOA6 CAND1 G3BP1 UBR5 AMOT ROR2 GATA2 CHD7 KDM6A ZIC3

1.10e-047635311MP:0003984
MousePhenoabnormal craniofacial morphology

NCOA6 CAND1 G3BP1 UBR5 CECR2 ROR2 MARCHF6 GSX2 CHD7 MBD5 FOXA2 KDM6A CDON ZIC3 HOXA1

1.20e-0413725315MP:0000428
MousePhenocraniofacial phenotype

NCOA6 CAND1 G3BP1 UBR5 CECR2 ROR2 MARCHF6 GSX2 CHD7 MBD5 FOXA2 KDM6A CDON ZIC3 HOXA1

1.20e-0413725315MP:0005382
MousePhenoabnormal brain development

NCOA6 UBR5 GSX2 TNKS CHD7 EN2 KDM6A CDON ZIC3 HOXA1

1.20e-046385310MP:0000913
MousePhenoabnormal internal male genitalia morphology

SLC25A3 MFSD14A PRDM9 CAND1 MAN2A2 ATXN2 ROR2 PELI3 CPEB4 MARCHF6 GATA2 WT1 JAZF1 CHD7 HSF5

1.41e-0413925315MP:0009205
MousePhenoabnormal male genitalia morphology

SLC25A3 MFSD14A PRDM9 CAND1 MAN2A2 ATXN2 ROR2 PELI3 CPEB4 MARCHF6 GATA2 WT1 JAZF1 CHD7 HSF5

1.70e-0414155315MP:0009198
MousePhenoabnormal male reproductive system morphology

SLC25A3 MFSD14A PRDM9 CAND1 MAN2A2 ATXN2 ROR2 PELI3 CPEB4 MARCHF6 GATA2 WT1 JAZF1 CHD7 HSF5

1.70e-0414155315MP:0001145
MousePhenoabnormal cardiovascular development

NCOA6 UBR5 AMOT GATA2 WT1 CHD7 ARID1A FOXA2 KDM6A ZIC3 HOXA1

1.72e-048025311MP:0002925
MousePhenoabnormal macrophage cytokine production

CLEC4F PELI3 DUSP11

1.75e-0429533MP:0011072
MousePhenoabnormal nervous system development

NCOA6 UBR5 CECR2 CPEB4 GSX2 TNKS CHD7 ARID1A FOXA2 EN2 KDM6A CDON ZIC3 HOXA1

1.77e-0412575314MP:0003861
MousePhenoabnormal craniofacial development

NCOA6 UBR5 ROR2 CHD7 FOXA2 CDON ZIC3 HOXA1

1.82e-04425538MP:0003935
MousePhenoabnormal total retina thickness

CCNT2 G3BP1 TLE1 TNKS MBD5 DUSP11

1.89e-04223536MP:0011963
MousePhenofacial asymmetry

CHD7 ZIC3

2.10e-046532MP:0030099
MousePhenodelayed neural tube closure

CECR2 ZIC3 HOXA1

2.15e-0431533MP:0002621
MousePhenoabnormal circumventricular organ morphology

GSX2 POU3F2 CHD7

2.15e-0431533MP:0013562
MousePhenolethality during fetal growth through weaning, incomplete penetrance

NCOA6 ATP7B CECR2 CPEB4 GATA2 TAB2 CHD7 MBD5 FOXA2 KDM6A CDON ZIC3 HOXA1

2.21e-0411245313MP:0011112
MousePhenoabnormal embryonic growth/weight/body size

TRIM33 NCOA6 CAND1 G3BP1 UBR5 AMOT ROR2 GATA2 WT1 CHD7 ARID1A FOXA2 KDM6A ZIC3

2.43e-0412955314MP:0002088
MousePhenoabnormal embryonic-extraembryonic boundary morphology

TRIM33 FOXA2 ZIC3

2.83e-0434533MP:0003890
MousePhenoabnormal malleus morphology

ROR2 CHD7 HOXA1

2.83e-0434533MP:0000029
MousePhenocraniofacial asymmetry

CHD7 ZIC3

2.93e-047532MP:0008863
MousePhenoprenatal growth retardation

TRIM33 NCOA6 CAND1 G3BP1 UBR5 AMOT ROR2 GATA2 CHD7 KDM6A ZIC3

3.44e-048695311MP:0010865
MousePhenoabnormal cerebellum vermis morphology

CHD7 EN2 ZIC3

3.65e-0437533MP:0000864
MousePhenoabnormal cerebellum posterior lobe morphology

CHD7 EN2

3.89e-048532MP:0009962
MousePhenoabnormal cerebellum posterior vermis morphology

CHD7 EN2

3.89e-048532MP:0000869
MousePhenoabnormal hindbrain morphology

ATXN2 CECR2 GSX2 CHD7 RNF180 EN2 ZIC3 HOXA1

4.45e-04485538MP:0000841
MousePhenointerrupted aortic arch

CHD7 ZIC3 HOXA1

4.95e-0441533MP:0004157
MousePhenoabsent posterior semicircular canal

CHD7 HOXA1

4.99e-049532MP:0003163
MousePhenoabnormal face development

CHD7 ZIC3

4.99e-049532MP:0030313
MousePhenocranioschisis

KDM6A ZIC3

4.99e-049532MP:0000919
MousePhenoabnormal extraembryonic tissue morphology

SLC25A3 TRIM33 NCOA6 CAND1 UBR5 AMOT ROR2 GATA2 ARID1A KDM6A ZIC3

5.01e-049085311MP:0002086
MousePhenointerrupted aorta

CHD7 ZIC3 HOXA1

5.71e-0443533MP:0010544
MousePhenopostnatal lethality

ATP7B CPEB4 GATA2 NRG2 POU3F2 TAB2 CHD7 MBD5 FOXA2 CDON ZIC3 HOXA1

6.03e-0410845312MP:0002082
MousePhenolethality during fetal growth through weaning, complete penetrance

JPH1 NCOA6 ATP7B G3BP1 ROR2 WT1 GSX2 POU3F2 MBD5 ARID1A FOXA2 KDM6A HOXA1

7.15e-0412695313MP:0011111
MousePhenoneonatal lethality

JPH1 NCOA6 ROR2 CPEB4 WT1 GSX2 ARID1A FOXA2 CDON HOXA1

7.29e-047995310MP:0002058
MousePhenodecreased embryo size

TRIM33 NCOA6 UBR5 AMOT ROR2 WT1 ARID1A FOXA2 KDM6A

7.49e-04659539MP:0001698
MousePhenoabnormal common crus morphology

CHD7 HOXA1

7.59e-0411532MP:0004922
MousePhenofusion of glossopharyngeal and vagus nerve

CHD7 HOXA1

7.59e-0411532MP:0004568
MousePhenoabnormal primitive streak elongation

FOXA2 ZIC3

7.59e-0411532MP:0012685
MousePhenoabnormal embryonic tissue morphology

TRIM33 UBR5 CECR2 ROR2 WT1 CHD7 ARID1A FOXA2 KDM6A CDON ZIC3 HOXA1

7.81e-0411165312MP:0002085
MousePhenopale yolk sac

UBR5 GATA2 ARID1A KDM6A

7.90e-04110534MP:0001722
MousePhenopericardial effusion

NCOA6 UBR5 WT1 ARID1A

8.17e-04111534MP:0005312
MousePhenoabnormal male reproductive gland morphology

SLC25A3 MFSD14A PRDM9 CAND1 MAN2A2 ATXN2 ROR2 CPEB4 MARCHF6 WT1 JAZF1 CHD7 HSF5

8.35e-0412905313MP:0013325
MousePhenoreduced female fertility

NCOA6 PRDM9 ATP7B WT1 CHD7 FOXA2

8.52e-04296536MP:0001923
MousePhenoabnormal embryonic tissue physiology

UBR5 WT1 CHD7 FOXA2 ZIC3 HOXA1

8.67e-04297536MP:0008932
MousePhenoabnormal blood vessel morphology

CCNT2 NCOA6 CAND1 UBR5 ZNF827 AMOT ROR2 GATA2 WT1 CHD7 ARID1A CDON ZIC3 HOXA1

8.95e-0414725314MP:0001614
MousePhenosmall testis

SLC25A3 PRDM9 CAND1 MAN2A2 ROR2 MARCHF6 WT1 JAZF1 CHD7 HSF5

9.15e-048235310MP:0001147
MousePhenoabnormal nose morphology

ROR2 GSX2 CHD7 MBD5 CDON

9.58e-04201535MP:0002233
MousePhenoabnormal prenatal growth/weight/body size

TRIM33 NCOA6 CAND1 G3BP1 UBR5 AMOT ROR2 GATA2 WT1 CHD7 ARID1A FOXA2 KDM6A ZIC3

1.03e-0314935314MP:0004196
MousePhenocaudal body truncation

ROR2 KDM6A ZIC3

1.11e-0354533MP:0004073
MousePhenoabnormal middle ear ossicle morphology

ROR2 CHD7 HOXA1

1.24e-0356533MP:0005105
MousePhenoabnormal palate development

NCOA6 ROR2 CHD7 CDON

1.43e-03129534MP:0009653
MousePhenosmall otic vesicle

CHD7 HOXA1

1.43e-0315532MP:0004310
MousePhenoabnormal embryo development

TRIM33 NCOA6 CAND1 G3BP1 UBR5 AMOT ROR2 GATA2 CHD7 ARID1A FOXA2 KDM6A ZIC3

1.46e-0313705313MP:0001672
MousePhenoembryonic lethality during organogenesis

NCOA6 UBR5 AMOT GATA2 WT1 TAB2 CHD7 ARID1A FOXA2 KDM6A

1.47e-038765310MP:0006207
MousePhenoabnormal rostral-caudal axis patterning

ROR2 FOXA2 KDM6A ZIC3

1.56e-03132534MP:0005221
MousePhenoabnormal pericardium morphology

NCOA6 UBR5 GATA2 WT1 ARID1A

1.58e-03225535MP:0000288
MousePhenosmall gonad

SLC25A3 PRDM9 CAND1 MAN2A2 ROR2 MARCHF6 WT1 JAZF1 CHD7 HSF5

1.59e-038855310MP:0001116
MousePhenoabnormal neural tube morphology

CECR2 CHD7 ARID1A FOXA2 KDM6A CDON ZIC3 HOXA1

1.61e-03591538MP:0002151
MousePhenoabnormal superior semicircular canal morphology

CHD7 HOXA1

1.64e-0316532MP:0003069
MousePhenointerrupted aortic arch, type b

CHD7 HOXA1

1.64e-0316532MP:0011659
MousePhenoabnormal brainstem morphology

CECR2 RNF180 EN2 ZIC3 HOXA1

1.64e-03227535MP:0005277
MousePhenoabnormal notochord morphology

FOXA2 KDM6A ZIC3

1.74e-0363533MP:0002825
MousePhenoabnormal interventricular septum morphology

ROR2 CHD7 ARID1A KDM6A ZIC3 HOXA1

1.79e-03342536MP:0000281
MousePhenoabnormal primary sex determination

SLC25A3 PRDM9 CAND1 MAN2A2 ROR2 MARCHF6 WT1 JAZF1 CHD7 HSF5

1.82e-039015310MP:0002211
MousePhenosmall middle ear ossicles

CHD7 HOXA1

1.85e-0317532MP:0030123
MousePhenoabsent olfactory bulb

NCOA6 CHD7

1.85e-0317532MP:0003451
MousePhenoabnormal vestibulocochlear ganglion morphology

CHD7 HOXA1

1.85e-0317532MP:0003703
MousePhenoabnormal gastrulation

TRIM33 UBR5 CHD7 ARID1A FOXA2 KDM6A ZIC3

1.86e-03469537MP:0001695
MousePhenoabnormal facial morphology

NCOA6 CECR2 ROR2 MARCHF6 GSX2 CHD7 MBD5 FOXA2 CDON ZIC3

1.95e-039105310MP:0003743
MousePhenoabnormal forebrain morphology

NCOA6 ATP7B CECR2 GSX2 POU3F2 CHD7 MBD5 ARID1A KDM6A CDON ZIC3

1.96e-0310725311MP:0000783
MousePhenoabnormal visceral endoderm morphology

TRIM33 AMOT ZIC3

1.99e-0366533MP:0011186
MousePhenodecreased total body fat amount

ZHX3 NCOA6 ROR2 PELI3 TNKS CHD7 MSTN

1.99e-03475537MP:0010025
MousePhenoabnormal adipose tissue amount

ZHX3 NCOA6 ROR2 PELI3 MAMLD1 POU3F2 TNKS CHD7 MBD5 MSTN HSF5

2.03e-0310775311MP:0005452
MousePhenoabnormal testis size

SLC25A3 PRDM9 CAND1 MAN2A2 ROR2 MARCHF6 WT1 JAZF1 CHD7 HSF5

2.04e-039155310MP:0004849
MousePhenoincreased trophoblast giant cell number

NCOA6 KDM6A

2.08e-0318532MP:0009397
MousePhenoabnormal anterior visceral endoderm morphology

TRIM33 ZIC3

2.08e-0318532MP:0008533
MousePhenoabnormal neurohypophysis morphology

POU3F2 CHD7

2.08e-0318532MP:0004164
MousePhenodecreased fetal cardiomyocyte proliferation

NCOA6 CHD7

2.08e-0318532MP:0011395
DomainZINC_FINGER_C2H2_2

ZNF823 ZHX3 PRDM9 ZNF827 ZNF589 WT1 JAZF1 ZNF784 ZNF446 ZIC3 ZNF646

8.99e-057756711PS50157
DomainZINC_FINGER_C2H2_1

ZNF823 ZHX3 PRDM9 ZNF827 ZNF589 WT1 JAZF1 ZNF784 ZNF446 ZIC3 ZNF646

9.20e-057776711PS00028
DomainZnf_C2H2-like

ZNF823 ZHX3 PRDM9 ZNF827 ZNF589 WT1 JAZF1 ZNF784 ZNF446 ZIC3 ZNF646

1.14e-047966711IPR015880
DomainZnf_C2H2

ZNF823 ZHX3 PRDM9 ZNF827 ZNF589 WT1 JAZF1 ZNF784 ZNF446 ZIC3 ZNF646

1.26e-048056711IPR007087
DomainZnF_C2H2

ZNF823 ZHX3 PRDM9 ZNF827 ZNF589 WT1 JAZF1 ZNF784 ZNF446 ZIC3 ZNF646

1.30e-048086711SM00355
Domain-

ZNF823 PRDM9 ZNF827 ZNF589 WT1 JAZF1 ZNF784 ZNF446 ZIC3 ZNF646

1.44e-0467967103.30.160.60
Domainzf-C2H2

ZNF823 PRDM9 ZNF827 ZNF589 WT1 JAZF1 ZNF784 ZNF446 ZIC3 ZNF646

1.70e-046936710PF00096
DomainZnf_C2H2/integrase_DNA-bd

ZNF823 PRDM9 ZNF827 ZNF589 WT1 JAZF1 ZNF784 ZNF446 ZIC3 ZNF646

1.72e-046946710IPR013087
DomainHomeobox

ZHX3 GSX2 POU3F2 EN2 HOXA1

1.52e-03234675PF00046
DomainHOMEOBOX_1

ZHX3 GSX2 POU3F2 EN2 HOXA1

1.58e-03236675PS00027
DomainHOX

ZHX3 GSX2 POU3F2 EN2 HOXA1

1.61e-03237675SM00389
DomainHOMEOBOX_2

ZHX3 GSX2 POU3F2 EN2 HOXA1

1.67e-03239675PS50071
DomainHomeobox_dom

ZHX3 GSX2 POU3F2 EN2 HOXA1

1.67e-03239675IPR001356
Domain-

ZHX3 GSX2 POU3F2 EN2 HOXA1

3.46e-032836751.10.10.60
DomainHomeobox_metazoa

GSX2 EN2 HOXA1

4.15e-0390673IPR020479
PathwayWP_KLEEFSTRA_SYNDROME

NCOA6 MBD5 ARID1A KDM6A

2.22e-0629464M48076
PathwayWP_ENDODERM_DIFFERENTIATION

CAND1 UBR5 FOXA2 ZIC3 HOXA1

9.82e-05143465M39591
PathwayPID_WNT_NONCANONICAL_PATHWAY

ROR2 TAB2 CHD7

1.51e-0432463M23
Pubmed

Identification and functional characterization of transcriptional activators in human cells.

TRIM33 ZHX3 TLE1 CECR2 FBRSL1 JAZF1 TNKS CHD7 ARID1A KDM6A

4.78e-09398671035016035
Pubmed

Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.

JPH1 TRIM33 GNL3L ATP7B UBR5 ZNF827 CECR2 ZNF589 CPEB4 FBRSL1 JAZF1 ARID1A ZNF646

1.81e-071116671331753913
Pubmed

Identification of the SOX2 Interactome by BioID Reveals EP300 as a Mediator of SOX2-dependent Squamous Differentiation and Lung Squamous Cell Carcinoma Growth.

NCOA6 TLE1 CHD7 ARID1A KDM6A

5.89e-078367528794006
Pubmed

RNF43 inhibits WNT5A-driven signaling and suppresses melanoma invasion and resistance to the targeted therapy.

G3BP1 ATXN2 AMOT ROR2 CPEB4 TAB2 ARID1A

7.71e-0726367734702444
Pubmed

Proximity-dependent Mapping of the Androgen Receptor Identifies Kruppel-like Factor 4 as a Functional Partner.

TRIM33 ZHX3 NCOA6 TLE1 CHD7 ARID1A KDM6A

8.74e-0726867733640491
Pubmed

Impact of cytosine methylation on DNA binding specificities of human transcription factors.

GATA2 GSX2 POU3F2 FOXA2 ZNF784 EN2 HSF5 ZIC3 HOXA1

1.00e-0654467928473536
Pubmed

PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.

TRIM33 CCNT2 ZHX3 NCOA6 CAND1 G3BP1 UBR5 ATXN2 WT1 CHD7 ARID1A KDM6A

1.17e-061103671234189442
Pubmed

A census of human transcription factors: function, expression and evolution.

ZHX3 ZBED2 GATA2 WT1 JAZF1 GSX2 POU3F2 FOXA2 EN2 HSF5 HOXA1

1.22e-06908671119274049
Pubmed

Congenital Diaphragmatic Hernia Overview

WT1 CHD7 ARID1A KDM6A

1.93e-064667420301533
Pubmed

Characterization of a new mouse mutant, flouncer, with a balance defect and inner ear malformation.

POU3F2 CHD7

3.66e-06267215353999
Pubmed

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

GNL3L CAND1 PXDN ATXN2 ZNF827 ROR2 ZNF589 FBRSL1 FNBP1L MBD5 ARID1A FBXO21 KDM6A

4.52e-061489671328611215
Pubmed

Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.

ZHX3 NCOA6 UBR5 AMOT TAB2 CHD7

4.92e-0622567612168954
Pubmed

Interaction network of human early embryonic transcription factors.

TRIM33 NCOA6 TLE1 FBRSL1 CHD7 ARID1A KDM6A

5.20e-0635167738297188
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

TRIM33 NCOA6 CAND1 AMOT CECR2 MARCHF6 FBRSL1 ZNF646

8.07e-0652967814621295
Pubmed

Ataxin-2-like is a regulator of stress granules and processing bodies.

G3BP1 ATXN2

1.10e-05367223209657
Pubmed

Directed expression of Gata2, Mash1, and Foxa2 synergize to induce the serotonergic neuron phenotype during in vitro differentiation of embryonic stem cells.

GATA2 FOXA2

1.10e-05367221472823
Pubmed

GATA-1 and GATA-2 binding to 3' enhancer of WT1 gene is essential for its transcription in acute leukemia and solid tumor cell lines.

GATA2 WT1

1.10e-05367219212333
Pubmed

Transcription factor protein interactomes reveal genetic determinants in heart disease.

SLC25A3 TRIM33 GNL3L AMOT TAB2 CHD7 ARID1A

1.44e-0541167735182466
Pubmed

Human transcription factor protein interaction networks.

TRIM33 ZHX3 NCOA6 G3BP1 ATXN2 TLE1 GATA2 FBRSL1 CHD7 ARID1A KDM6A ZIC3

1.63e-051429671235140242
Pubmed

The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.

SLC25A3 CCNT2 ATXN2 AMOT TAB2 TNKS FOXA2 ZIC3 DUSP11 HOXA1 ZNF646

1.76e-051203671129180619
Pubmed

Proteomic Analysis of the EWS-Fli-1 Interactome Reveals the Role of the Lysosome in EWS-Fli-1 Turnover.

TRIM33 ZHX3 NCOA6 AMOT CECR2 ARID1A EN2

1.79e-0542567724999758
Pubmed

Groucho/transducin-like enhancer of split (TLE) family members interact with the yeast transcriptional co-repressor SSN6 and mammalian SSN6-related proteins: implications for evolutionary conservation of transcription repression mechanisms.

TLE1 KDM6A

2.19e-0546729854018
Pubmed

Beyond conventional chemotherapy: Emerging molecular targeted and immunotherapy strategies in urothelial carcinoma.

ARID1A KDM6A

2.19e-05467226138514
Pubmed

Dynamic expression of Groucho-related genes Grg1 and Grg3 in foregut endoderm and antagonism of differentiation.

TLE1 FOXA2

2.19e-05467220108349
Pubmed

Reversal of axonal pathways from rhombomere 3 correlates with extra Hox expression domains.

EN2 HOXA1

2.19e-0546728096385
Pubmed

Deletion and expression analysis of AZFa genes on the human Y chromosome revealed a major role for DBY in male infertility.

USP9Y KDM6A

2.19e-05467210767340
Pubmed

Comparative Application of BioID and TurboID for Protein-Proximity Biotinylation.

TRIM33 NCOA6 ATXN2 TLE1 MAMLD1 ARID1A FOXA2

2.85e-0545767732344865
Pubmed

TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.

ZNF823 ZHX3 NCOA6 FBRSL1 TAB2 CHD7 ARID1A KDM6A

3.09e-0563867831182584
Pubmed

A murine Zic3 transcript with a premature termination codon evades nonsense-mediated decay during axis formation.

FOXA2 ZIC3

3.64e-05567223471918
Pubmed

Isolation of novel cDNAs by subtractions between the anterior mesendoderm of single mouse gastrula stage embryos.

AMOT FOXA2

3.64e-05567210328927
Pubmed

ZHX proteins regulate podocyte gene expression during the development of nephrotic syndrome.

ZHX3 WT1

3.64e-05567217056598
Pubmed

Transducin-like enhancer of split proteins, the human homologs of Drosophila groucho, interact with hepatic nuclear factor 3beta.

TLE1 FOXA2

3.64e-05567210748198
Pubmed

The protein network surrounding the human telomere repeat binding factors TRF1, TRF2, and POT1.

CCNT2 TNKS CHD7 FBXO21 DUSP11

4.03e-0519767520811636
Pubmed

Cell-autonomous FGF signaling regulates anteroposterior patterning and neuronal differentiation in the mesodiencephalic dopaminergic progenitor domain.

GATA2 FOXA2 EN2

4.66e-053667322278924
Pubmed

Ihog and Boi elicit Hh signaling via Ptc but do not aid Ptc in sequestering the Hh ligand.

FOXA2 CDON

5.46e-05667225231763
Pubmed

Hox/Pbx and Brn binding sites mediate Pax3 expression in vitro and in vivo.

POU3F2 HOXA1

5.46e-05667215465489
Pubmed

Developmental expression of membrane type 4-matrix metalloproteinase (Mt4-mmp/Mmp17) in the mouse embryo.

WT1 FOXA2

7.63e-05767228926609
Pubmed

Joint regulation of the MAP1B promoter by HNF3beta/Foxa2 and Engrailed is the result of a highly conserved mechanism for direct interaction of homeoproteins and Fox transcription factors.

FOXA2 EN2

7.63e-05767212642491
Pubmed

Knockdown of ALR (MLL2) reveals ALR target genes and leads to alterations in cell adhesion and growth.

NCOA6 KDM6A

1.02e-04867217178841
Pubmed

The type II activin receptors are essential for egg cylinder growth, gastrulation, and rostral head development in mice.

FOXA2 EN2

1.02e-04867210452853
Pubmed

Nolz1 promotes striatal neurogenesis through the regulation of retinoic acid signaling.

TLE1 GSX2

1.02e-04867220735826
Pubmed

HNF-3 beta as a regulator of floor plate development.

FOXA2 EN2

1.02e-0486728287471
Pubmed

The variant Polycomb Repressor Complex 1 component PCGF1 interacts with a pluripotency sub-network that includes DPPA4, a regulator of embryogenesis.

TRIM33 UBR5 CECR2 WT1 CHD7 ZIC3

1.17e-0439667626687479
Pubmed

Epigenetic-focused CRISPR/Cas9 screen identifies (absent, small, or homeotic)2-like protein (ASH2L) as a regulator of glioblastoma cell survival.

NCOA6 UBR5 KDM6A

1.26e-045067337974198
Pubmed

The cell surface membrane proteins Cdo and Boc are components and targets of the Hedgehog signaling pathway and feedback network in mice.

FOXA2 CDON

1.30e-04967216647304
Pubmed

Identification of Pax2-regulated genes by expression profiling of the mid-hindbrain organizer region.

POU3F2 EN2

1.30e-04967215872005
Pubmed

Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.

TRIM33 UBR5 FBRSL1 TAB2 CHD7 FNBP1L ARID1A

1.38e-0458867738580884
Pubmed

Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.

ZHX3 GATA2 WT1 JAZF1 ARID1A KDM6A ZNF446 ZNF646

1.60e-0480867820412781
Pubmed

Hox and Pbx factors control retinoic acid synthesis during hindbrain segmentation.

EN2 HOXA1

1.63e-041067221497760
Pubmed

Requirement for Lim1 in head-organizer function.

FOXA2 EN2

1.63e-04106727700351
Pubmed

Spatial distribution of the full-length members of the Grg family during embryonic neurogenesis reveals a "Grg-mediated repression map" in the mouse telencephalon.

TLE1 GSX2

1.63e-041067230571765
Pubmed

Tiam1 regulates the Wnt/Dvl/Rac1 signaling pathway and the differentiation of midbrain dopaminergic neurons.

ROR2 FOXA2

1.63e-041067223109420
Pubmed

GDE2 promotes neurogenesis by glycosylphosphatidylinositol-anchor cleavage of RECK.

GATA2 EN2

1.63e-041067223329048
Pubmed

Cyclin F-Dependent Degradation of RBPJ Inhibits IDH1R132H-Mediated Tumorigenesis.

G3BP1 ATXN2

1.99e-041167230254149
Pubmed

Trim33 is required for appropriate development of pre-cardiogenic mesoderm.

TRIM33 FOXA2

1.99e-041167230940539
Pubmed

Septal contributions to olfactory bulb interneuron diversity in the embryonic mouse telencephalon: role of the homeobox gene Gsx2.

GSX2 ZIC3

1.99e-041167228814342
Pubmed

Maintenance of the specification of the anterior definitive endoderm and forebrain depends on the axial mesendoderm: a study using HNF3beta/Foxa2 conditional mutants.

AMOT FOXA2

1.99e-041167211846474
Pubmed

Neuronal defects in the hindbrain of Hoxa1, Hoxb1 and Hoxb2 mutants reflect regulatory interactions among these Hox genes.

GATA2 HOXA1

1.99e-041167214522873
Pubmed

FoxH1 (Fast) functions to specify the anterior primitive streak in the mouse.

FOXA2 EN2

1.99e-041167211358869
Pubmed

Genome-wide impact of the BRG1 SWI/SNF chromatin remodeler on the transforming growth factor beta transcriptional program.

TRIM33 ARID1A

1.99e-041167218003620
Pubmed

Synergistic interaction between Gdf1 and Nodal during anterior axis development.

FOXA2 EN2

2.38e-041267216564040
Pubmed

The transcription factor HNF3beta is required in visceral endoderm for normal primitive streak morphogenesis.

FOXA2 EN2

2.38e-04126729671576
Pubmed

DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity.

SLC25A3 TRIM33 UBR5 ZNF827 CTC1 ARID1A

2.41e-0445367629656893
Pubmed

Loss of BAF (mSWI/SNF) Complexes Causes Global Transcriptional and Chromatin State Changes in Forebrain Development.

POU3F2 ARID1A KDM6A

2.74e-046567326655900
Pubmed

The splanchnic mesodermal plate directs spleen and pancreatic laterality, and is regulated by Bapx1/Nkx3.2.

WT1 FOXA2

2.81e-041367215329346
Pubmed

Conditional blastocyst complementation of a defective Foxa2 lineage efficiently promotes the generation of the whole lung.

WT1 FOXA2

2.81e-041367237861292
Pubmed

Demethylation of H3K27 regulates polycomb recruitment and H2A ubiquitination.

NCOA6 KDM6A

2.81e-041367217761849
Pubmed

Higher-Order Kidney Organogenesis from Pluripotent Stem Cells.

WT1 EN2

2.81e-041367229129523
Pubmed

Disruption of TCF4 regulatory networks leads to abnormal cortical development and mental disabilities.

POU3F2 CDON

2.81e-041367230705426
Pubmed

Developmental changes in human fetal testicular cell numbers and messenger ribonucleic acid levels during the second trimester.

MAMLD1 WT1

2.81e-041367217848411
Pubmed

A targeted mouse Otx2 mutation leads to severe defects in gastrulation and formation of axial mesoderm and to deletion of rostral brain.

FOXA2 EN2

2.81e-04136728565836
Pubmed

Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells.

TRIM33 CAND1 CECR2 CHD7 ARID1A KDM6A

2.90e-0446967627634302
Pubmed

Overlapping roles and collective requirement for the coreceptors GAS1, CDO, and BOC in SHH pathway function.

FOXA2 CDON

3.28e-041467221664576
Pubmed

Zic3 is critical for early embryonic patterning during gastrulation.

FOXA2 ZIC3

3.28e-041467216397896
Pubmed

GABAergic and glutamatergic identities of developing midbrain Pitx2 neurons.

GATA2 FOXA2

3.28e-041467221246650
Pubmed

Kupffer-cell-derived IL-6 is repurposed for hepatocyte dedifferentiation via activating progenitor genes from injury-specific enhancers.

CLEC4F ARID1A

3.28e-041467236787740
Pubmed

The ubiquitin ligase TRIM25 targets ERG for degradation in prostate cancer.

TRIM33 UBR5

3.28e-041467227626314
Pubmed

The HIV-1 Tat protein recruits a ubiquitin ligase to reorganize the 7SK snRNP for transcriptional activation.

SLC25A3 CCNT2 GNL3L G3BP1 AMOT OSBPL1A CHD7 USP9Y FBXO21

3.57e-04115367929845934
Pubmed

Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function.

FOXA2 EN2

3.78e-04156728837770
Pubmed

HNF-3 beta is essential for node and notochord formation in mouse development.

FOXA2 EN2

3.78e-04156728069909
Pubmed

Cdon mutation and fetal ethanol exposure synergize to produce midline signaling defects and holoprosencephaly spectrum disorders in mice.

FOXA2 CDON

3.78e-041567223071453
Pubmed

Goosecoid and HNF-3beta genetically interact to regulate neural tube patterning during mouse embryogenesis.

FOXA2 EN2

3.78e-04156729226455
Pubmed

Foxa2 identifies a cardiac progenitor population with ventricular differentiation potential.

WT1 FOXA2

3.78e-041567228195173
Pubmed

A predictive model of bifunctional transcription factor signaling during embryonic tissue patterning.

FOXA2 CDON

3.78e-041567225458012
Pubmed

The BRCT-domain containing protein PTIP links PAX2 to a histone H3, lysine 4 methyltransferase complex.

NCOA6 KDM6A

3.78e-041567217925232
Pubmed

A High-Density Map for Navigating the Human Polycomb Complexome.

NCOA6 CAND1 FBRSL1 MBD5 FBXO21 KDM6A

3.86e-0449567627705803
Pubmed

A high-resolution molecular atlas of the fetal mouse lower urogenital tract.

ROR2 GATA2 WT1

4.18e-047567321905163
Pubmed

Regulation of epidermal differentiation through KDF1-mediated deubiquitination of IKKα.

JPH1 SLC25A3 ATXN2 AMOT

4.30e-0418267432239614
Pubmed

Endothelial cell interactions initiate dorsal pancreas development by selectively inducing the transcription factor Ptf1a.

WT1 FOXA2

4.31e-041667214736742
Pubmed

Boc is a receptor for sonic hedgehog in the guidance of commissural axons.

FOXA2 CDON

4.31e-041667217086203
Pubmed

The Hedgehog-binding proteins Gas1 and Cdo cooperate to positively regulate Shh signaling during mouse development.

FOXA2 CDON

4.31e-041667217504941
Pubmed

Identification and characterization of VPO1, a new animal heme-containing peroxidase.

PXDN FOXA2

4.31e-041667218929642
Pubmed

Developmental competence of the gut endoderm: genetic potentiation by GATA and HNF3/fork head proteins.

GATA2 FOXA2

4.31e-041667210208738
Pubmed

H3K4 mono- and di-methyltransferase MLL4 is required for enhancer activation during cell differentiation.

NCOA6 KDM6A

4.31e-041667224368734
Pubmed

Agonist-specific Protein Interactomes of Glucocorticoid and Androgen Receptor as Revealed by Proximity Mapping.

NCOA6 CHD7 ARID1A

4.69e-047867328611094
Pubmed

The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.

SLC25A3 TRIM33 ZHX3 NCOA6 G3BP1 ATXN2 CHD7 ARID1A

4.86e-0495467836373674
Pubmed

Amyloid Precursor Protein (APP) May Act as a Substrate and a Recognition Unit for CRL4CRBN and Stub1 E3 Ligases Facilitating Ubiquitination of Proteins Involved in Presynaptic Functions and Neurodegeneration.

CAND1 UBR5 FBXO21

4.87e-047967327325702
Pubmed

A critical role for the chromatin remodeller CHD7 in anterior mesoderm during cardiovascular development.

WT1 CHD7

4.88e-041767226102480
Pubmed

Sall4 is essential for mouse primordial germ cell specification by suppressing somatic cell program genes.

WT1 HOXA1

4.88e-041767225263278
Pubmed

MLL3 and MLL4 Methyltransferases Bind to the MAFA and MAFB Transcription Factors to Regulate Islet β-Cell Function.

NCOA6 KDM6A

4.88e-041767226180087
InteractionPAX9 interactions

NCOA6 TLE1 FBRSL1 CHD7 ARID1A KDM6A HOXA1

2.24e-07130667int:PAX9
InteractionSOX7 interactions

TRIM33 TLE1 CECR2 CHD7 ARID1A KDM6A

2.82e-0782666int:SOX7
InteractionERG interactions

TRIM33 NCOA6 UBR5 TLE1 FBRSL1 CHD7 ARID1A KDM6A

6.56e-07223668int:ERG
InteractionSOX17 interactions

TRIM33 NCOA6 TLE1 CHD7 ARID1A KDM6A

6.77e-0795666int:SOX17
InteractionEGR2 interactions

TRIM33 NCOA6 TLE1 FBRSL1 CHD7 ARID1A KDM6A

1.43e-06171667int:EGR2
InteractionTBR1 interactions

TLE1 FBRSL1 CHD7 ARID1A KDM6A HOXA1

1.88e-06113666int:TBR1
InteractionTBXT interactions

NCOA6 TLE1 FBRSL1 CHD7 ARID1A KDM6A

2.19e-06116666int:TBXT
InteractionGATA2 interactions

NCOA6 TLE1 GATA2 FBRSL1 CHD7 ARID1A KDM6A

3.92e-06199667int:GATA2
InteractionPAX2 interactions

TLE1 FBRSL1 WT1 CHD7 KDM6A

8.65e-0685665int:PAX2
InteractionEN2 interactions

TLE1 FOXA2 EN2

1.19e-0514663int:EN2
InteractionSOX10 interactions

TLE1 POU3F2 CHD7 ARID1A KDM6A

1.27e-0592665int:SOX10
InteractionFOXI1 interactions

TRIM33 TLE1 FBRSL1 ARID1A KDM6A

1.27e-0592665int:FOXI1
InteractionSOX9 interactions

NCOA6 TLE1 CHD7 ARID1A KDM6A

1.65e-0597665int:SOX9
InteractionCRX interactions

TRIM33 TLE1 ROR2 FBRSL1 CHD7 ARID1A KDM6A

1.92e-05254667int:CRX
InteractionLHX1 interactions

TLE1 CHD7 ARID1A FOXA2 KDM6A

2.21e-05103665int:LHX1
InteractionNELL2 interactions

TRIM33 PXDN CTC1 HOXA1

2.72e-0553664int:NELL2
InteractionALG13 interactions

ATXN2 TLE1 ROR2 CPEB4 ARID1A HOXA1

2.99e-05183666int:ALG13
InteractionPAX8 interactions

TLE1 FBRSL1 CHD7 ARID1A KDM6A

3.17e-05111665int:PAX8
InteractionHNF4A interactions

TRIM33 NCOA6 TLE1 CHD7 ARID1A FOXA2 KDM6A

3.20e-05275667int:HNF4A
InteractionGATA3 interactions

TLE1 GATA2 FBRSL1 CHD7 ARID1A KDM6A

3.37e-05187666int:GATA3
InteractionTPRX2 interactions

NCOA6 TLE1 ARID1A KDM6A

3.39e-0556664int:TPRX2
InteractionTLX3 interactions

NCOA6 TLE1 ROR2 FBRSL1 CHD7 ARID1A KDM6A

4.58e-05291667int:TLX3
InteractionFEV interactions

NCOA6 TLE1 FBRSL1 CHD7 ARID1A KDM6A

5.33e-05203666int:FEV
InteractionPAX7 interactions

TLE1 FBRSL1 CHD7 ARID1A KDM6A

5.38e-05124665int:PAX7
InteractionSP7 interactions

TRIM33 NCOA6 TLE1 FBRSL1 CHD7 ARID1A KDM6A

6.03e-05304667int:SP7
InteractionVSX1 interactions

TLE1 FBRSL1 CHD7 USP9Y

6.49e-0566664int:VSX1
InteractionTLE1 interactions

TLE1 GATA2 FOXA2 EN2 KDM6A HOXA1

6.96e-05213666int:TLE1
InteractionRSPH1 interactions

JPH1 TRIM33 OSBPL1A USP9Y KDM6A

6.99e-05131665int:RSPH1
InteractionGCM1 interactions

TLE1 FBRSL1 ARID1A KDM6A

7.30e-0568664int:GCM1
InteractionRNF43 interactions

G3BP1 UBR5 ATXN2 AMOT ROR2 CPEB4 TAB2 ARID1A

7.46e-05427668int:RNF43
InteractionSMG7 interactions

NCOA6 G3BP1 ATXN2 AMOT TLE1 CPEB4 ARID1A

8.16e-05319667int:SMG7
InteractionTLX2 interactions

G3BP1 TLE1 FBRSL1 CHD7 ARID1A

1.02e-04142665int:TLX2
InteractionELF5 interactions

TRIM33 TLE1 CHD7 ARID1A KDM6A

1.21e-04147665int:ELF5
InteractionSOX6 interactions

ZHX3 G3BP1 TLE1 FBRSL1 CHD7

1.64e-04157665int:SOX6
InteractionR3HDM1 interactions

G3BP1 ATXN2 CPEB4 HOXA1

1.66e-0484664int:R3HDM1
InteractionCEBPA interactions

TRIM33 CCNT2 ZHX3 NCOA6 CAND1 G3BP1 UBR5 ATXN2 GATA2 WT1 CHD7 ARID1A KDM6A

1.70e-0412456613int:CEBPA
InteractionIRF4 interactions

TLE1 CHD7 ARID1A KDM6A

1.74e-0485664int:IRF4
InteractionPAX6 interactions

NCOA6 TLE1 FBRSL1 CHD7 ARID1A KDM6A HOXA1

1.91e-04366667int:PAX6
InteractionFOXA2 interactions

TLE1 FOXA2 EN2

2.04e-0435663int:FOXA2
InteractionLHX4 interactions

TRIM33 TLE1 CHD7 ARID1A KDM6A

2.13e-04166665int:LHX4
InteractionPRRC2B interactions

G3BP1 ATXN2 TLE1 CECR2 CPEB4 GATA2

2.29e-04265666int:PRRC2B
InteractionTLX1 interactions

TLE1 FBRSL1 CHD7 ARID1A KDM6A

2.72e-04175665int:TLX1
InteractionTEAD1 interactions

TLE1 FBRSL1 CHD7 ARID1A KDM6A

2.79e-04176665int:TEAD1
InteractionBMI1 interactions

SLC25A3 CAND1 G3BP1 UBR5 ATXN2 CPEB4 GATA2 KDM6A DUSP11

2.84e-04659669int:BMI1
InteractionANKS3 interactions

OSBPL1A TNKS ZNF446

3.27e-0441663int:ANKS3
InteractionAR interactions

TRIM33 ZHX3 NCOA6 CAND1 G3BP1 UBR5 TLE1 TAB2 CHD7 ARID1A KDM6A

3.47e-049926611int:AR
InteractionRBBP5 interactions

CCNT2 NCOA6 GATA2 CHD7 ARID1A KDM6A

3.51e-04287666int:RBBP5
InteractionSMAP2 interactions

G3BP1 ATXN2 ROR2 CPEB4 FBRSL1

3.87e-04189665int:SMAP2
InteractionUBAP2L interactions

TRIM33 G3BP1 UBR5 ATXN2 CPEB4 FBRSL1

4.29e-04298666int:UBAP2L
InteractionKLF5 interactions

NCOA6 G3BP1 TLE1 ARID1A KDM6A

4.46e-04195665int:KLF5
InteractionNUP35 interactions

TRIM33 NCOA6 ATXN2 TLE1 MAMLD1 ARID1A FOXA2

4.64e-04424667int:NUP35
InteractionRFPL4B interactions

TAB2 ZNF784 ZNF446

5.22e-0448663int:RFPL4B
InteractionFOS interactions

TRIM33 NCOA6 TLE1 FNBP1L ARID1A KDM6A

5.47e-04312666int:FOS
InteractionPAGR1 interactions

NCOA6 GATA2 KDM6A

6.24e-0451663int:PAGR1
InteractionMCRIP2 interactions

G3BP1 ATXN2 CPEB4

6.24e-0451663int:MCRIP2
InteractionNFIC interactions

TLE1 GATA2 FBRSL1 ARID1A KDM6A

6.25e-04210665int:NFIC
Cytoband2q32.2

OSGEPL1 MSTN

2.18e-04156722q32.2
Cytoband5q33.1

FAT2 G3BP1

6.67e-04266725q33.1
GeneFamilyZinc fingers C2H2-type|ZF class homeoboxes and pseudogenes

ZNF823 ZHX3 PRDM9 ZNF827 ZNF589 WT1 JAZF1 ZNF784 ZNF446 ZIC3 ZNF646

5.96e-06718531128
GeneFamilyBlood group antigens|CD molecules|I-set domain containing|Immunoglobulin like domain containing

PXDN ROR2 NRG2 CDON

1.26e-03161534593
CoexpressionDACOSTA_UV_RESPONSE_VIA_ERCC3_COMMON_DN

TRIM33 ZHX3 UBR5 ATXN2 TLE1 MARCHF6 MAMLD1 TAB2 FNBP1L

2.48e-06466669M13522
CoexpressionDACOSTA_UV_RESPONSE_VIA_ERCC3_DN

TRIM33 ZHX3 CAND1 UBR5 ATXN2 TLE1 MARCHF6 MAMLD1 TAB2 TNKS FNBP1L

8.81e-068566611M4500
ToppCell367C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_4|CD8+_Cytotoxic_T-cell / Donor, Lineage, Cell class and subclass (all cells)

MAN2A2 TLE1 GATA2 CHD7

3.60e-067066437e34ef782b253c43628d5bb2fe5e0294573d0ef
ToppCell3'_v3-blood-Lymphocytic_Invariant-Inducer-like-ILC3|blood / Manually curated celltypes from each tissue

ZNF827 TLE1 OSBPL1A GATA2 FNBP1L

3.65e-06157665eb2520c237543ea4869d4386afc0457b111f6193
ToppCellhuman_hepatoblastoma-Tumor_cells|World / Sample and Cell Type and Tumor Cluster (all cells)

UBR5 ATXN2 TNKS MBD5 KDM6A

9.72e-06192665916fbec1c7ab7969bda711886ac88e877e30c280
ToppCellhuman_hepatoblastoma|World / Sample and Cell Type and Tumor Cluster (all cells)

UBR5 ATXN2 TNKS MBD5 KDM6A

9.97e-06193665e6a688bc834f845ff64dae1be64f073eec5091a1
ToppCellsevere-low-quality_cells|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

TRIM33 CTC1 GATA2 FNBP1L USP9Y

9.97e-061936659337bc93e3904c7fc7c93c328518bcd6453b1e8c
ToppCellLPS_only-Epithelial_alveolar-AT_1-Differentiating_AT1|LPS_only / Treatment groups by lineage, cell group, cell type

ZNF827 CECR2 CHD7 GSAP FOXA2

1.18e-052006652dadf317a42a7e27cc1fac74f91b806c93a57108
Diseasemonocyte percentage of leukocytes

ATXN2 CECR2 GATA2 JAZF1 ARMC9 CHD7 MBD5 ARID1A ANKRD55

2.40e-05731639EFO_0007989
Diseasesystemic juvenile idiopathic arthritis, polyarticular juvenile idiopathic arthritis, rheumatoid factor negative, oligoarticular juvenile idiopathic arthritis

ATXN2 JAZF1 ANKRD55

8.66e-0540633EFO_1001999, EFO_1002019, EFO_1002020
Diseasequinolinate measurement

CCNT2 ATXN2

9.36e-057632EFO_0800175
Diseasered blood cell density measurement

TRIM33 UBR5 ATXN2 ZNF827 CPEB4 FBRSL1 FNBP1L FBXO21 ANKRD55

1.00e-04880639EFO_0007978
Diseaseurate measurement

NCOA6 ATXN2 ZNF827 CPEB4 FBRSL1 FNBP1L MBD5 ARID1A ANKRD55

1.14e-04895639EFO_0004531
Diseasecholesteryl ester measurement, very low density lipoprotein cholesterol measurement

ZHX3 ATXN2 PELI3 JAZF1 ARID1A

1.21e-04225635EFO_0008317, EFO_0010351
Diseaseglucose measurement

ZHX3 ATXN2 FBRSL1 JAZF1 FNBP1L FOXA2

1.60e-04380636EFO_0004468
Diseaseuric acid measurement

ZHX3 ZNF827 CPEB4 FBRSL1 FNBP1L ARID1A HSF5

3.17e-04610637EFO_0004761
DiseaseCrohn's disease

ATXN2 CPEB4 JAZF1 TAB2 GSAP ANKRD55

3.56e-04441636EFO_0000384
Diseaselung non-small cell carcinoma (is_marker_for)

UBR5 TAB2 ARID1A FOXA2

4.75e-04169634DOID:3908 (is_marker_for)
DiseaseLeukemia, Myelocytic, Acute

PXDN CTC1 GATA2 WT1

5.19e-04173634C0023467
Diseaselymphocyte percentage of leukocytes

UBR5 ATXN2 CECR2 GATA2 JAZF1 CHD7 ARID1A

5.30e-04665637EFO_0007993
Diseasefeeling nervous measurement

NCOA6 POU3F2 MBD5

8.65e-0487633EFO_0009597
Diseaseleft ventricular structural measurement

ZHX3 PXDN ATXN2

8.94e-0488633EFO_0008205
Diseasecoronary artery disease

ZHX3 NCOA6 ATXN2 ZNF827 WT1 TAB2 TNKS FBXO21 ANKRD55

9.35e-041194639EFO_0001645
Diseasetotal cholesterol measurement, very low density lipoprotein cholesterol measurement

ATXN2 PELI3 TNKS ARID1A

1.36e-03224634EFO_0004574, EFO_0008317
Diseasecolon adenocarcinoma (is_implicated_in)

UBR5 KDM6A

1.41e-0326632DOID:234 (is_implicated_in)
Diseaseeosinophil measurement

PXDN ATXN2 CHD7

1.61e-03108633EFO_0803540
Diseasecancer

NCOA6 ATXN2 FBRSL1 JAZF1 TAB2

1.65e-03400635MONDO_0004992
DiseaseBilateral Wilms Tumor

WT1 ARID1A

1.76e-0329632C2930471
Diseasepappalysin‐1 measurement

PXDN ATXN2

1.76e-0329632EFO_0010618
Diseasetype 1 diabetes mellitus

ATXN2 BTN2A3P JAZF1 ANKRD55

1.80e-03242634MONDO_0005147
Diseaseneuroimaging measurement

JPH1 ZHX3 G3BP1 ATXN2 ROR2 CPEB4 ARMC9 CHD7

1.92e-031069638EFO_0004346
Diseaseserum IgA measurement

ATXN2 ANKRD55

2.00e-0331632EFO_0004912

Protein segments in the cluster

PeptideGeneStartEntry
LHRAGTHHSPQNQFP

BTN2A3P

486

Q96KV6
QHTHQHQHTFAPFPA

FBRSL1

451

Q9HCM7
NQGDHSAHLPRPQQH

AMOT

341

Q4VCS5
FQQGPSISLHSGLHH

CCNT2

381

O60583
LRHHQFLQHSSPGSP

CTC1

486

Q2NKJ3
GFHASLAQRNPNAHH

ATP7B

626

P35670
RHLHNPSSGQNFQHL

ANKRD55

536

Q3KP44
PSSGQNFQHLSPNRH

ANKRD55

541

Q3KP44
APSLRHSVQQFHHHP

CHD7

246

Q9P2D1
QHFPPRGFQSNHPHS

CECR2

1176

Q9BXF3
AGPQQNSHDHGFPNH

ARID1A

196

O14497
NMNVHSLPHGHHQPF

FBXO21

536

O94952
QGNRFHFDIKPPLHH

OSGEPL1

231

Q9H4B0
AHLARANPFNTPHLQ

SLC25A3

6

Q00325
AQHARNGHPQALPAA

ARMC9

676

Q7Z3E5
PAPSPVQHHQHQAAQ

ATXN2

1166

Q99700
GLRHHTINFHPPVSA

JAZF1

221

Q86VZ6
GGHAVSHPPVQQQAH

KDM6A

451

O15550
HHIPNPSNGELHSQY

JPH1

536

Q9HDC5
CNHSPQVFHPHVQAL

CAND1

506

Q86VP6
HHHHQPQQPGSAAAA

GSX2

136

Q9BZM3
NLHPPHFASFVHQGQ

FAT2

1026

Q9NYQ8
RSFHLADPCQHSPQH

FAM205A

1101

Q6ZU69
CPAHQNRSLANGPSH

NRG2

446

O14511
LEHAAPPFNAAGHHQ

MARCHF6

176

O60337
HHHHPQPATYQTSGN

HOXA1

71

P49639
HHPPISAFHAEGLNN

OSBPL1A

651

Q9BXW6
GSHSHPHNTQAPGEA

MFSD14A

466

Q96MC6
VNSLPSSHGHHFPNV

NCOA6

1186

Q14686
SSHGHHFPNVAAPTQ

NCOA6

1191

Q14686
HVERNHSSQNFPGPS

PRDM9

406

Q9NQV7
VLNAQHPDSHHPGLA

GATA2

16

P23769
PGHFFHLLNVQHPDL

GSAP

351

A4D1B5
NQEVRGPPQQHGHHN

FNBP1L

511

Q5T0N5
IQGHSAPRHFHTQTQ

DUSP11

291

O75319
HPDSHQLFIGNLPHE

G3BP1

336

Q13283
FHNAQPIHPSARHLT

CDON

346

Q4KMG0
PQHQHGNSFTSRQDP

MAMLD1

656

Q13495
HDPTRHQNGGNFPRS

MAN2A2

31

P49641
TNFVHSNSPVPNHHL

MBD5

766

Q9P267
PHHHQNATPSPAAFI

CPEB4

31

Q17RY0
APGNHQHPHRITNFF

EN2

56

P19622
PLPQAFNTSGNHTAH

ERVFC1

266

P60507
HAAPVTRRQFPHGAH

RNF180

531

Q86T96
QQQQAAAHLLGPPHH

FOXA2

341

Q9Y261
GPLHHFHNPHFRRDQ

HSF5

106

Q4G112
HLQRQHSNPGHAGPF

TRIM33

616

Q9UPN9
FQARGPHFNPSAIHN

TAB2

616

Q9NYJ8
AQTPLPHGTHAFHAA

PELI3

431

Q8N2H9
PSAPHFVHPNDHANR

GNL3L

41

Q9NVN8
YPHTHLVHQANPRGS

MSTN

321

O14793
FVRLGPTHSPNHNFQ

ROR2

151

Q01974
GALQSNGHPLSHAHQ

POU3F2

46

P20265
TGHLPFEPNNHHHFG

CLEC4F

81

Q8N1N0
GHPSPTGHVDNNQVH

ZIC3

171

O60481
SHQHSFQTHERPPTG

ZNF823

146

P16415
QQLQAQHLSHGHGPP

TLE1

126

Q04724
FHLAPARAGHHPNQY

ZBED2

61

Q9BTP6
HHHHQQQLQPAPGAS

TNKS

11

O95271
HNNRITHLVPGTFNH

PXDN

166

Q92626
HFQNHRPGEATSAQP

ZNF646

866

O15015
GHTPSHHAAQFPNHS

WT1

161

P19544
NNHVHGQPYTGPAAH

USP9Y

2511

O00507
GNHGHQEPASTSFHP

ZNF446

191

Q9NWS9
GSNLSFSPPSHHAQQ

ZNF827

151

Q17R98
ELHNHPIPGFHAGNQ

ZNF589

101

Q86UQ0
FLSLQQQPPVHAQHH

ZHX3

271

Q9H4I2
LQQGHPLHSFQAHQS

WDR87

231

Q6ZQQ6
GHPNHPLHASQNSAR

UBR5

1866

O95071
RHGAPNPAQSHLHVQ

nan

31

Q6ZVH6
NFRKHQRTHFHGPGP

ZNF784

266

Q8NCA9