Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctiontransmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential

GRIN3A CHRFAM7A CHRNA7

6.40e-0457593GO:1904315
GeneOntologyMolecularFunctionacetylcholine binding

CHRFAM7A CHRNA7

6.56e-0413592GO:0042166
GeneOntologyMolecularFunctionneurotransmitter receptor activity involved in regulation of postsynaptic membrane potential

GRIN3A CHRFAM7A CHRNA7

7.44e-0460593GO:0099529
GeneOntologyMolecularFunctionchloride channel regulator activity

CHRFAM7A CHRNA7

8.79e-0415592GO:0017081
GeneOntologyMolecularFunctiontransmitter-gated channel activity

GRIN3A CHRFAM7A CHRNA7

9.40e-0465593GO:0022835
GeneOntologyMolecularFunctiontransmitter-gated monoatomic ion channel activity

GRIN3A CHRFAM7A CHRNA7

9.40e-0465593GO:0022824
GeneOntologyMolecularFunctionadenylate cyclase binding

CHRFAM7A CHRNA7

1.00e-0316592GO:0008179
GeneOntologyMolecularFunctionacetylcholine-gated monoatomic cation-selective channel activity

CHRFAM7A CHRNA7

1.13e-0317592GO:0022848
GeneOntologyMolecularFunctionadenylate cyclase activity

NPR2 ADCY7

1.27e-0318592GO:0004016
GeneOntologyMolecularFunctiontoxic substance binding

CHRFAM7A CHRNA7

1.27e-0318592GO:0015643
GeneOntologyMolecularFunctionpostsynaptic neurotransmitter receptor activity

GRIN3A CHRFAM7A CHRNA7

1.42e-0375593GO:0098960
GeneOntologyMolecularFunctionextracellular ligand-gated monoatomic ion channel activity

GRIN3A CHRFAM7A CHRNA7

1.53e-0377593GO:0005230
GeneOntologyMolecularFunctionacetylcholine receptor activity

CHRFAM7A CHRNA7

2.09e-0323592GO:0015464
GeneOntologyMolecularFunctioncyclase activity

NPR2 ADCY7

2.27e-0324592GO:0009975
GeneOntologyMolecularFunctionpeptide binding

NLN MRGPRX1 MRGPRX3 CHRFAM7A CHRNA7

2.46e-03318595GO:0042277
GeneOntologyMolecularFunctionphosphorus-oxygen lyase activity

NPR2 ADCY7

2.46e-0325592GO:0016849
GeneOntologyMolecularFunctionmannosyltransferase activity

DPY19L4 ALG3

3.09e-0328592GO:0000030
GeneOntologyMolecularFunctionneurotransmitter receptor activity

GRIN3A CHRFAM7A CHRNA7

3.23e-03100593GO:0030594
GeneOntologyMolecularFunctionN-methyltransferase activity

METTL9 HEMK1 FDXACB1

3.71e-03105593GO:0008170
GeneOntologyMolecularFunctionneuropeptide binding

MRGPRX1 MRGPRX3

5.35e-0337592GO:0042923
GeneOntologyBiologicalProcesspositive regulation of heart rate involved in baroreceptor response to decreased systemic arterial blood pressure

CHRFAM7A CHRNA7

7.77e-062582GO:0001988
GeneOntologyBiologicalProcessbaroreceptor response to decreased systemic arterial blood pressure

CHRFAM7A CHRNA7

2.33e-053582GO:0001982
GeneOntologyBiologicalProcessgeneration of ovulation cycle rhythm

CHRFAM7A CHRNA7

4.65e-054582GO:0060112
GeneOntologyBiologicalProcessresponse to chloroquine

MRGPRX1 MRGPRX3

7.73e-055582GO:1902349
GeneOntologyBiologicalProcesssensory processing

CHRFAM7A CHRNA7

7.73e-055582GO:0050893
GeneOntologyBiologicalProcessregulation of systemic arterial blood pressure by carotid sinus baroreceptor feedback

CHRFAM7A CHRNA7

1.16e-046582GO:0001978
GeneOntologyBiologicalProcessregulation of systemic arterial blood pressure by baroreceptor feedback

CHRFAM7A CHRNA7

2.15e-048582GO:0003025
GeneOntologyBiologicalProcesspositive regulation of CoA-transferase activity

CHRFAM7A CHRNA7

2.76e-049582GO:1905920
GeneOntologyCellularComponentspine apparatus membrane

CHRFAM7A CHRNA7

2.43e-053602GO:0098897
GeneOntologyCellularComponentspine apparatus

CHRFAM7A CHRNA7

2.88e-049602GO:0097444
MousePhenoairway basal cell hyperplasia

CHRFAM7A CHRNA7

1.01e-052452MP:0011115
MousePhenoabnormal airway basal cell differentiation

CHRFAM7A CHRNA7

1.01e-052452MP:0011114
MousePhenoabnormal airway basal cell morphology

CHRFAM7A CHRNA7

1.01e-052452MP:0011113
MousePhenoabnormal nicotine-mediated receptor currents

CHRFAM7A CHRNA7

6.05e-054452MP:0009475
MousePhenofailure of neuromuscular synapse presynaptic differentiation

CHRFAM7A CHRNA7

1.51e-046452MP:0001054
MousePhenodecreased pruritus

MRGPRX1 MRGPRX3

2.11e-047452MP:0010073
MousePhenoabnormal GABAergic neuron physiology

CHRFAM7A CHRNA7

2.80e-048452MP:0011987
DomainLETM1_RBD

LETM2 LETM1

3.04e-053602IPR033122
DomainLETM1

LETM2 LETM1

3.04e-053602IPR011685
DomainLETM1_RBD

LETM2 LETM1

3.04e-053602PS51758
DomainLETM1

LETM2 LETM1

3.04e-053602PF07766
DomainMRGPCRFAMILY

MRGPRX1 MRGPRX3

5.48e-0411602IPR026234
DomainA/G_cyclase_CS

NPR2 ADCY7

1.34e-0317602IPR018297
DomainNucleotide_cyclase

NPR2 ADCY7

1.50e-0318602IPR029787
Domain-

NPR2 ADCY7

1.50e-03186023.30.70.1230
Domain-

DDR1 FBXO6 GLB1L

1.67e-03736032.60.120.260
DomainGUANYLATE_CYCLASE_1

NPR2 ADCY7

1.68e-0319602PS00452
DomainGuanylate_cyc

NPR2 ADCY7

1.68e-0319602PF00211
DomainGUANYLATE_CYCLASE_2

NPR2 ADCY7

1.68e-0319602PS50125
DomainA/G_cyclase

NPR2 ADCY7

1.68e-0319602IPR001054
DomainCYCc

NPR2 ADCY7

1.68e-0319602SM00044
Domain-

CHRFAM7A CHRNA7

2.46e-03236021.20.120.370
DomainAcetylcholine_rcpt_TM

CHRFAM7A CHRNA7

2.46e-0323602IPR027361
DomainGalactose-bd-like

DDR1 FBXO6 GLB1L

3.43e-0394603IPR008979
DomainPeripla_BP_I

NPR2 GRIN3A

6.97e-0339602IPR028082
Domain-

DIO2 GLRX2 NME8

7.10e-031226033.40.30.10
DomainF-box-like

FBXO6 FBXL12

8.80e-0344602PF12937
DomainThioredoxin-like_fold

DIO2 GLRX2 NME8

8.81e-03132603IPR012336
DomainNeurotransmitter_ion_chnl_CS

CHRFAM7A CHRNA7

9.19e-0345602IPR018000
DomainNeur_chan_memb

CHRFAM7A CHRNA7

9.59e-0346602PF02932
DomainNeur_chan_LBD

CHRFAM7A CHRNA7

1.00e-0247602PF02931
DomainNEUROTR_ION_CHANNEL

CHRFAM7A CHRNA7

1.00e-0247602PS00236
DomainNeurotrans-gated_channel_TM

CHRFAM7A CHRNA7

1.00e-0247602IPR006029
Domain-

CHRFAM7A CHRNA7

1.00e-02476022.70.170.10
DomainNeur_channel

CHRFAM7A CHRNA7

1.00e-0247602IPR006201
DomainNeur_chan_lig-bd

CHRFAM7A CHRNA7

1.00e-0247602IPR006202
Pubmed

Activation of nicotinic acetylcholine receptor α7 subunit limits Zika viral infection via promoting autophagy and ferroptosis.

CHRFAM7A CHRNA7

3.23e-06263238822526
Pubmed

Enhancing cognitive function in chronic TBI: The Role of α7 nicotinic acetylcholine receptor modulation.

CHRFAM7A CHRNA7

3.23e-06263238070724
Pubmed

Inflammatory cytokines decrease the expression of nicotinic acetylcholine receptor during the cell maturation.

CHRFAM7A CHRNA7

3.23e-06263219626424
Pubmed

Follistatin-related protein 1 interacting partner of Syndecan-1 promotes an aggressive phenotype on Oral Squamous cell carcinoma (OSCC) models.

FSTL1 SDC1

3.23e-06263234990821
Pubmed

Episodic memory performance predicted by the 2bp deletion in exon 6 of the "alpha 7-like" nicotinic receptor subunit gene.

CHRFAM7A CHRNA7

3.23e-06263217012698
Pubmed

Hydroxynorketamine, but not ketamine, acts via α7 nicotinic acetylcholine receptor to control presynaptic function and gene expression.

CHRFAM7A CHRNA7

3.23e-06263238253622
Pubmed

{alpha}7-nAChR-mediated suppression of hyperexcitability of colonic dorsal root ganglia neurons in experimental colitis.

CHRFAM7A CHRNA7

3.23e-06263220595621
Pubmed

Cholinergic Pathway Suppresses Pulmonary Innate Immunity Facilitating Pneumonia After Stroke.

CHRFAM7A CHRNA7

3.23e-06263226451017
Pubmed

Nicotine stimulates nerve growth factor in lung fibroblasts through an NFκB-dependent mechanism.

CHRFAM7A CHRNA7

3.23e-06263225296021
Pubmed

The role of dorsal root ganglia alpha-7 nicotinic acetylcholine receptor in complete Freund's adjuvant-induced chronic inflammatory pain.

CHRFAM7A CHRNA7

3.23e-06263234514543
Pubmed

Genetic deletion of α7 nicotinic acetylcholine receptors induces an age-dependent Alzheimer's disease-like pathology.

CHRFAM7A CHRNA7

3.23e-06263234453977
Pubmed

Perinatal hypoxia-ischemia reduces α 7 nicotinic receptor expression and selective α 7 nicotinic receptor stimulation suppresses inflammation and promotes microglial Mox phenotype.

CHRFAM7A CHRNA7

3.23e-06263224757672
Pubmed

Inhibition of pancreatic acinar mitochondrial thiamin pyrophosphate uptake by the cigarette smoke component 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone.

CHRFAM7A CHRNA7

3.23e-06263226999808
Pubmed

α7 nicotinic acetylcholine receptor (α7nAChR) expression in bone marrow-derived non-T cells is required for the inflammatory reflex.

CHRFAM7A CHRNA7

3.23e-06263222183893
Pubmed

Delayed procedural learning in α7-nicotinic acetylcholine receptor knockout mice.

CHRFAM7A CHRNA7

3.23e-06263221679297
Pubmed

Positive allosteric modulators of α7 nicotinic acetylcholine receptors affect neither the function of other ligand- and voltage-gated ion channels and acetylcholinesterase, nor β-amyloid content.

CHRFAM7A CHRNA7

3.23e-06263227129924
Pubmed

Neuroprotection afforded by nicotine against oxygen and glucose deprivation in hippocampal slices is lost in alpha7 nicotinic receptor knockout mice.

CHRFAM7A CHRNA7

3.23e-06263217291692
Pubmed

Sensorimotor gating and spatial learning in α7-nicotinic receptor knockout mice.

CHRFAM7A CHRNA7

3.23e-06263223521765
Pubmed

Evidence that alpha7 nicotinic receptor modulates glutamate release from mouse neocortical gliosomes.

CHRFAM7A CHRNA7

3.23e-06263217462791
Pubmed

Effect of α7 nicotinic acetylcholine receptor activation on cardiac fibroblasts: a mechanism underlying RV fibrosis associated with cigarette smoke exposure.

CHRFAM7A CHRNA7

3.23e-06263228258105
Pubmed

alpha7 Nicotinic acetylcholine receptor knockout selectively enhances ethanol-, but not beta-amyloid-induced neurotoxicity.

CHRFAM7A CHRNA7

3.23e-06263215555774
Pubmed

Mice deficient in the alpha7 neuronal nicotinic acetylcholine receptor lack alpha-bungarotoxin binding sites and hippocampal fast nicotinic currents.

CHRFAM7A CHRNA7

3.23e-0626329364063
Pubmed

The cholinergic anti-inflammatory system limits T cell infiltration into the neurodegenerative CNS, but cannot counteract complex CNS inflammation.

CHRFAM7A CHRNA7

3.23e-06263219344760
Pubmed

Expression of the α7 nAChR Subunit Duplicate Form (CHRFAM7A) Was Down-Regulated in Patients with Intracranial Infection and Reduced Inflammation in in vitro Model by p38 MAPK.

CHRFAM7A CHRNA7

3.23e-06263235100606
Pubmed

Evidence suggesting that the mouse sperm acrosome reaction initiated by the zona pellucida involves an alpha7 nicotinic acetylcholine receptor.

CHRFAM7A CHRNA7

3.23e-06263212606407
Pubmed

ST/b and DBA/2 mice differ in brain alpha-bungarotoxin binding and alpha 7 nicotinic receptor subunit mRNA levels: a quantitative autoradiographic analysis.

CHRFAM7A CHRNA7

3.23e-0626328804729
Pubmed

Loss of α7nAChR enhances endothelial-to-mesenchymal transition after myocardial infarction via NF-κB activation.

CHRFAM7A CHRNA7

3.23e-06263235926661
Pubmed

The alpha7 nicotinic receptor agonist 4OH-GTS-21 protects axotomized septohippocampal cholinergic neurons in wild type but not amyloid-overexpressing transgenic mice.

CHRFAM7A CHRNA7

3.23e-06263217640819
Pubmed

Genetic variations in CHRNA7 or CHRFAM7 and susceptibility to dementia.

CHRFAM7A CHRNA7

3.23e-06263222300029
Pubmed

The pathophysiology of traumatic brain injury in alpha7 nicotinic cholinergic receptor knockout mice.

CHRFAM7A CHRNA7

3.23e-06263216545784
Pubmed

Lung epithelial response to cigarette smoke and modulation by the nicotinic alpha 7 receptor.

CHRFAM7A CHRNA7

3.23e-06263229117258
Pubmed

Contribution of α7 nicotinic receptor to airway epithelium dysfunction under nicotine exposure.

CHRFAM7A CHRNA7

3.23e-06263223431157
Pubmed

Deficiency of alpha7 cholinergic receptors facilitates bacterial clearance in Escherichia coli peritonitis.

CHRFAM7A CHRNA7

3.23e-06263218627272
Pubmed

Bidirectional Regulation of Aggression in Mice by Hippocampal Alpha-7 Nicotinic Acetylcholine Receptors.

CHRFAM7A CHRNA7

3.23e-06263229114104
Pubmed

GTS-21 ameliorates polymicrobial sepsis-induced hepatic injury by modulating autophagy through α7nAchRs in mice.

CHRFAM7A CHRNA7

3.23e-06263232018068
Pubmed

CHRNA7 and CHRFAM7A mRNAs: co-localized and their expression levels altered in the postmortem dorsolateral prefrontal cortex in major psychiatric disorders.

CHRFAM7A CHRNA7

3.23e-06263226206074
Pubmed

Nicotine elicits prolonged calcium signaling along ventral hippocampal axons.

CHRFAM7A CHRNA7

3.23e-06263224349346
Pubmed

Autophagy is Involved in Neuroprotective Effect of Alpha7 Nicotinic Acetylcholine Receptor on Ischemic Stroke.

CHRFAM7A CHRNA7

3.23e-06263233995108
Pubmed

E-cigarette-induced pulmonary inflammation and dysregulated repair are mediated by nAChR α7 receptor: role of nAChR α7 in SARS-CoV-2 Covid-19 ACE2 receptor regulation.

CHRFAM7A CHRNA7

3.23e-06263232552811
Pubmed

The role of nicotinic acetylcholine receptor (nAChR) α7 subtype in the functional interaction between nicotine and ethanol in mouse cerebellum.

CHRFAM7A CHRNA7

3.23e-06263221143250
Pubmed

Wnt/β-catenin signaling plays an essential role in α7 nicotinic receptor-mediated neuroprotection of dopaminergic neurons in a mouse Parkinson's disease model.

CHRFAM7A CHRNA7

3.23e-06263228551099
Pubmed

Cholinergic modulation of appetite-related synapses in mouse lateral hypothalamic slice.

CHRFAM7A CHRNA7

3.23e-06263216319313
Pubmed

Reduced CHRNA7 expression in C3H mice is associated with increases in hippocampal parvalbumin and glutamate decarboxylase-67 (GAD67) as well as altered levels of GABA(A) receptor subunits.

CHRFAM7A CHRNA7

3.23e-06263224836856
Pubmed

Modulation of the MAPKs pathways affects Aβ-induced cognitive deficits in Alzheimer's disease via activation of α7nAChR.

CHRFAM7A CHRNA7

3.23e-06263231904546
Pubmed

Splenectomy inactivates the cholinergic antiinflammatory pathway during lethal endotoxemia and polymicrobial sepsis.

CHRFAM7A CHRNA7

3.23e-06263216785311
Pubmed

Studies of sperm from mutant mice suggesting that two neurotransmitter receptors are important to the zona pellucida-initiated acrosome reaction.

CHRFAM7A CHRNA7

3.23e-06263215948184
Pubmed

Alpha7 nicotinic acetylcholine receptor mediates chronic nicotine inhalation-induced cardiopulmonary dysfunction.

CHRFAM7A CHRNA7

3.23e-06263235678315
Pubmed

Normal apoptosis levels in mice expressing one alpha7 nicotinic receptor null and one L250T mutant allele.

CHRFAM7A CHRNA7

3.23e-06263211409732
Pubmed

Age-Associated Tooth Loss and Oral Microbial Dysbiosis in a Mouse Genetic Model of Chronic Nicotine Exposure.

CHRFAM7A CHRNA7

3.23e-06263233117372
Pubmed

Impaired synaptic plasticity in the visual cortex of mice lacking α7-nicotinic receptor subunit.

CHRFAM7A CHRNA7

3.23e-06263225797465
Pubmed

Functional role of alpha7 nicotinic receptor in physiological control of cutaneous homeostasis.

CHRFAM7A CHRNA7

3.23e-06263212628457
Pubmed

Activation of α-7 nicotinic acetylcholine receptor reduces ischemic stroke injury through reduction of pro-inflammatory macrophages and oxidative stress.

CHRFAM7A CHRNA7

3.23e-06263225157794
Pubmed

Selective alpha7 nicotinic receptor activation by AZD0328 enhances cortical dopamine release and improves learning and attentional processes.

CHRFAM7A CHRNA7

3.23e-06263219615981
Pubmed

Combined administration of anisodamine and neostigmine rescued acute lethal crush syndrome through α7nAChR-dependent JAK2-STAT3 signaling.

CHRFAM7A CHRNA7

3.23e-06263227874086
Pubmed

Splenic nerve denervation attenuates depression-like behaviors in Chrna7 knock-out mice via the spleen-gut-brain axis.

CHRFAM7A CHRNA7

3.23e-06263238944290
Pubmed

Pharmacologic activation of cholinergic alpha7 nicotinic receptors mitigates depressive-like behavior in a mouse model of chronic stress.

CHRFAM7A CHRNA7

3.23e-06263229197398
Pubmed

Nicotine withdrawal-induced inattention is absent in alpha7 nAChR knockout mice.

CHRFAM7A CHRNA7

3.23e-06263228243714
Pubmed

Cholinergic signaling via the α7 nicotinic acetylcholine receptor regulates the migration of monocyte-derived macrophages during acute inflammation.

CHRFAM7A CHRNA7

3.23e-06263238178134
Pubmed

Mesenchymal Stem Cells or Interleukin-6 Improve Episodic Memory of Mice Lacking α7 Nicotinic Acetylcholine Receptors.

CHRFAM7A CHRNA7

3.23e-06263231202708
Pubmed

Prenatal nicotine exposure alters lung function and airway geometry through α7 nicotinic receptors.

CHRFAM7A CHRNA7

3.23e-06263222246862
Pubmed

alpha7 Nicotinic receptor gene delivery into mouse hippocampal neurons leads to functional receptor expression, improved spatial memory-related performance, and tau hyperphosphorylation.

CHRFAM7A CHRNA7

3.23e-06263217218065
Pubmed

Stimulation of the α7 nicotinic acetylcholine receptor protects against sepsis by inhibiting Toll-like receptor via phosphoinositide 3-kinase activation.

CHRFAM7A CHRNA7

3.23e-06263224298024
Pubmed

In hippocampal oriens interneurons anti-Hebbian long-term potentiation requires cholinergic signaling via α7 nicotinic acetylcholine receptors.

CHRFAM7A CHRNA7

3.23e-06263223325242
Pubmed

Lung eosinophilia induced by house dust mites or ovalbumin is modulated by nicotinic receptor α7 and inhibited by cigarette smoke.

CHRFAM7A CHRNA7

3.23e-06263229975102
Pubmed

α7-nAChR Knockout Mice Decreases Biliary Hyperplasia and Liver Fibrosis in Cholestatic Bile Duct-Ligated Mice.

CHRFAM7A CHRNA7

3.23e-06263229580318
Pubmed

Glutamatergic synapse formation is promoted by α7-containing nicotinic acetylcholine receptors.

CHRFAM7A CHRNA7

3.23e-06263222649244
Pubmed

Alpha-7 Nicotinic Receptor Dampens Murine Osteoblastic Response to Inflammation and Age-Related Osteoarthritis.

CHRFAM7A CHRNA7

3.23e-06263235479080
Pubmed

Olfactory discrimination varies in mice with different levels of α7-nicotinic acetylcholine receptor expression.

CHRFAM7A CHRNA7

3.23e-06263220713028
Pubmed

Broad-spectrum efficacy across cognitive domains by alpha7 nicotinic acetylcholine receptor agonism correlates with activation of ERK1/2 and CREB phosphorylation pathways.

CHRFAM7A CHRNA7

3.23e-06263217898229
Pubmed

Antimuscle atrophy effect of nicotine targets muscle satellite cells partly through an α7 nicotinic receptor in a murine hindlimb ischemia model.

CHRFAM7A CHRNA7

3.23e-06263224811002
Pubmed

[Activation of α7 nAChR improves white fat homeostasis and promotes beige adipogenesis and thermogenesis in obese mice].

CHRFAM7A CHRNA7

3.23e-06263238597441
Pubmed

Alpha7-nicotinic receptors modulate nicotine-induced reinforcement and extracellular dopamine outflow in the mesolimbic system in mice.

CHRFAM7A CHRNA7

3.23e-06263221901321
Pubmed

Activation of Nicotinic Acetylcholine Receptors Decreases Apoptosis in Human and Female Murine Pancreatic Islets.

CHRFAM7A CHRNA7

3.23e-06263227471776
Pubmed

Dopamine release in prefrontal cortex in response to beta-amyloid activation of alpha7 * nicotinic receptors.

CHRFAM7A CHRNA7

3.23e-06263217935702
Pubmed

Targeting α-7 nicotinic acetylcholine receptor in the enteric nervous system: a cholinergic agonist prevents gut barrier failure after severe burn injury.

CHRFAM7A CHRNA7

3.23e-06263222688057
Pubmed

Cortical parvalbumin GABAergic deficits with α7 nicotinic acetylcholine receptor deletion: implications for schizophrenia.

CHRFAM7A CHRNA7

3.23e-06263224983521
Pubmed

α7 Nicotinic acetylcholine receptor agonist attenuates neuropathological changes associated with intracerebral hemorrhage in mice.

CHRFAM7A CHRNA7

3.23e-06263222820264
Pubmed

Stimulation of α7-nAChRs coordinates autophagy and apoptosis signaling in experimental knee osteoarthritis.

CHRFAM7A CHRNA7

3.23e-06263233953172
Pubmed

Different Effects of Nicotine and N-Stearoyl-ethanolamine on Episodic Memory and Brain Mitochondria of α7 Nicotinic Acetylcholine Receptor Knockout Mice.

CHRFAM7A CHRNA7

3.23e-06263232028688
Pubmed

Neuronal nicotinic alpha7 receptors modulate early neutrophil infiltration to sites of skin inflammation.

CHRFAM7A CHRNA7

3.23e-06263220624304
Pubmed

Cytokine-induced alterations of α7 nicotinic receptor in colonic CD4 T cells mediate dichotomous response to nicotine in murine models of Th1/Th17- versus Th2-mediated colitis.

CHRFAM7A CHRNA7

3.23e-06263221784975
Pubmed

Genetic variation in CHRNA7 and CHRFAM7A is associated with nicotine dependence and response to varenicline treatment.

CHRFAM7A CHRNA7

3.23e-06263230089821
Pubmed

Nicotinic acetylcholine receptor activation reduces skeletal muscle inflammation of mdx mice.

CHRFAM7A CHRNA7

3.23e-06263220615555
Pubmed

Nicotine physical dependence in the mouse: involvement of the alpha7 nicotinic receptor subtype.

CHRFAM7A CHRNA7

3.23e-06263215896732
Pubmed

Lack of acetylcholine nicotine alpha 7 receptor suppresses development of collagen-induced arthritis and adaptive immunity.

CHRFAM7A CHRNA7

3.23e-06263220659128
Pubmed

Stimulation of α7 nicotinic acetylcholine receptor by nicotine increases suppressive capacity of naturally occurring CD4+CD25+ regulatory T cells in mice in vitro.

CHRFAM7A CHRNA7

3.23e-06263220843956
Pubmed

Mice homozygous for the L250T mutation in the alpha7 nicotinic acetylcholine receptor show increased neuronal apoptosis and die within 1 day of birth.

CHRFAM7A CHRNA7

3.23e-06263210800961
Pubmed

Activation of α7 Nicotinic Acetylcholine Receptor Ameliorates Zymosan-Induced Acute Kidney Injury in BALB/c Mice.

CHRFAM7A CHRNA7

3.23e-06263230429582
Pubmed

A transgenic mouse model reveals fast nicotinic transmission in hippocampal pyramidal neurons.

CHRFAM7A CHRNA7

3.23e-06263221501254
Pubmed

T-cell receptor activation decreases excitability of cortical interneurons by inhibiting α7 nicotinic receptors.

CHRFAM7A CHRNA7

3.23e-06263224381265
Pubmed

α7-cholinergic receptor mediates vagal induction of splenic norepinephrine.

CHRFAM7A CHRNA7

3.23e-06263221339364
Pubmed

Cardiopulmonary arrest and resuscitation disrupts cholinergic anti-inflammatory processes: a role for cholinergic α7 nicotinic receptors.

CHRFAM7A CHRNA7

3.23e-06263221368056
Pubmed

Genetic variation within the Chrna7 gene modulates nicotine reward-like phenotypes in mice.

CHRFAM7A CHRNA7

3.23e-06263224289814
Pubmed

Requisite role of the cholinergic alpha7 nicotinic acetylcholine receptor pathway in suppressing Gram-negative sepsis-induced acute lung inflammatory injury.

CHRFAM7A CHRNA7

3.23e-06263219949071
Pubmed

Expression of human apolipoprotein A-II and its effect on high density lipoproteins in transgenic mice.

CHRFAM7A CHRNA7

3.23e-0626321400473
Pubmed

Characterization of allelic variants at chromosome 15q14 in schizophrenia.

CHRFAM7A CHRNA7

3.23e-06263216417613
Pubmed

Dynamic Impairment of Olfactory Behavior and Signaling Mediated by an Olfactory Corticofugal System.

CHRFAM7A CHRNA7

3.23e-06263232817250
Pubmed

Reversible inhibition of GABAA receptors by alpha7-containing nicotinic receptors on the vertebrate postsynaptic neurons.

CHRFAM7A CHRNA7

3.23e-06263217204496
Pubmed

Absence of alpha7-containing neuronal nicotinic acetylcholine receptors does not prevent nicotine-induced seizures.

CHRFAM7A CHRNA7

3.23e-06263211834293
Pubmed

Nicotinic acetylcholine receptor α7 subunit is time-dependently expressed in distinct cell types during skin wound healing in mice.

CHRFAM7A CHRNA7

3.23e-06263221437621
Cytoband11p15.1

MRGPRX1 MRGPRX3 PLEKHA7

7.97e-056063311p15.1
ToppCellNeuronal-Inhibitory-iA-iA_1(SST_PAX6)-SST|Neuronal / cells hierarchy compared to all cells using T-Statistic

DDR1 SDK2 GRIN3A THSD7B ANKFN1 CHRFAM7A CHRNA7

1.38e-0820063753d5e427f0cbf5cf0b63efe4ec01da302f555704
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1_SST_CXCL14|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SDK2 LYPD3 GRIN3A THSD7B CHRFAM7A CHRNA7

1.68e-071736360ba64e5385fe714f876002520f8b5202809bf11e
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1_SST_CXCL14|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

DDR1 SDK2 GRIN3A THSD7B ANKFN1 CHRNA7

2.12e-07180636b6efdb4d319ef6f87f559acd974e5a71b06a2322
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SDK2 GRIN3A THSD7B ANKFN1 CHRFAM7A CHRNA7

2.26e-071826367dc61e901428cea04f00ebb0939a44d21a6145c6
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1_ADARB2_ADAM33|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

GRIN3A THSD7B PLEKHA7 ANKFN1 CHRFAM7A CHRNA7

2.34e-071836365e361be3ae3fe05098968e58427630127bd12675
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SDK2 GRIN3A THSD7B ANKFN1 CHRFAM7A CHRNA7

2.49e-0718563608fad1e3c3cc5f1c3eb6629a49c094b628e75a92
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1_ADARB2_ADAM33|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

GRIN3A THSD7B PLEKHA7 ANKFN1 CHRFAM7A CHRNA7

2.65e-0718763602105c82a9ba79d2f19e002188377fc3440770c2
ToppCellNeuronal-Inhibitory-iA-iA_1(SST_PAX6)-SST-BAGE2|Neuronal / cells hierarchy compared to all cells using T-Statistic

DDR1 SDK2 GRIN3A THSD7B ANKFN1 CHRNA7

3.94e-0720063626f07d271e984f375145e4c10528fba44a5811e1
ToppCellNeuronal-Inhibitory-iA-iA_1(SST_PAX6)-SST-BAGE2-L1-2|Neuronal / cells hierarchy compared to all cells using T-Statistic

DDR1 SDK2 GRIN3A THSD7B ANKFN1 CHRNA7

3.94e-07200636c3637827ceba16b0d7956c280dd2ddbc8b1ba55e
ToppCellNeuronal-Inhibitory-iA-iA_1(SST_PAX6)|Neuronal / cells hierarchy compared to all cells using T-Statistic

DDR1 SDK2 GRIN3A THSD7B CHRFAM7A CHRNA7

3.94e-07200636d0167f96314be78b6d867bbcc6e4396071d931b8
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1_SST_CXCL14|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SDK2 GRIN3A THSD7B CHRFAM7A CHRNA7

4.65e-06173635af85fb9f6e26a044ca4d23e5872039b1a7b73b1b
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1_SST_CXCL14|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SDK2 GRIN3A THSD7B CHRFAM7A CHRNA7

5.50e-06179635c7afbd10072d36a35cd20ae73670d76b9cefd22d
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1_ADARB2_ADAM33|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

GRIN3A THSD7B PLEKHA7 CHRFAM7A CHRNA7

5.80e-061816352f3d04d22d4ac016e61709ea5af3d48885c946c4
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SDK2 GRIN3A THSD7B CHRFAM7A CHRNA7

6.12e-06183635e3ffef2b57dc5b96466dccc9cd54ba326ccf378a
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SDK2 GRIN3A THSD7B CHRFAM7A CHRNA7

6.45e-06185635027020754dbf71b0034791f9a34ae795e3b85f81
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1_ADARB2_ADAM33|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

DDR1 THSD7B ANKFN1 CHRFAM7A CHRNA7

6.45e-06185635487fa382232564f075960899d50afa0edae5d258
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_PAX6-Inh_L1_PAX6_CA4|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SDK2 FSTL1 GRIN3A CHRFAM7A CHRNA7

6.97e-06188635ee572246e0c2f41bdbc29a03edc67b831af95c09
ToppCelldroplet-Lung-nan-3m-Mesenchymal-Myofibroblast|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ILDR2 FSTL1 CYP2E1 SBSPON THSD7B

8.33e-06195635d32716a12014522492becbde1088dc1106308490
ToppCelldroplet-Lung-nan-3m-Mesenchymal-pulmonary_interstitial_fibroblast|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ILDR2 FSTL1 CYP2E1 SBSPON THSD7B

8.33e-06195635b913d5df50c88a3a255f516a1aa42419c6701e1e
ToppCellNeuronal-Inhibitory-iA-iA_1(SST_PAX6)-PAX6-CDH12|Neuronal / cells hierarchy compared to all cells using T-Statistic

SDK2 FSTL1 GRIN3A CHRFAM7A CHRNA7

9.41e-06200635c74bc12e13d002dedaaf75a2244ec111e47524e1
ToppCellNeuronal-Inhibitory-iA-iA_1(SST_PAX6)-PAX6-CDH12-L1-2|Neuronal / cells hierarchy compared to all cells using T-Statistic

SDK2 FSTL1 GRIN3A CHRFAM7A CHRNA7

9.41e-06200635ead9eb579bb25fde05fc15602e3d05ab6617f7ac
ToppCellNeuronal-Inhibitory-iA-iA_3(VIP)-VIP_3-ADAMTSL1|Neuronal / cells hierarchy compared to all cells using T-Statistic

SDK2 THSD7B ANKFN1 CHRFAM7A CHRNA7

9.41e-06200635e1fca7ee2dc18c7fded53c3561f519c1fcd9767a
ToppCellNeuronal-Inhibitory-iA-iA_1(SST_PAX6)-SST-CHRNA4-L1|Neuronal / cells hierarchy compared to all cells using T-Statistic

DDR1 THSD7B PLEKHA7 ANKFN1 CHRNA7

9.41e-06200635e2ced6eb1de9a526c34c7558b9c637854916e624
ToppCellNeuronal-Inhibitory-iA-iA_3(VIP)-VIP_3-ADAMTSL1-L1-3|Neuronal / cells hierarchy compared to all cells using T-Statistic

SDK2 THSD7B ANKFN1 CHRFAM7A CHRNA7

9.41e-062006354409471479dd7c0f770bcb84ba7b3652c4706743
ToppCellNeuronal-Inhibitory-iA-iA_1(SST_PAX6)-SST-CHRNA4|Neuronal / cells hierarchy compared to all cells using T-Statistic

DDR1 THSD7B PLEKHA7 ANKFN1 CHRNA7

9.41e-062006359bc924755e5a4c464408e6103b86bf1b4e8c58b5
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Sst-Sst_Tac2_Tacstd2|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

CEACAM18 SBSPON GRIN3A ADCY7

2.46e-05119634e868453c02dcf0e07821886b81ca739887d43c67
ToppCellBronchial_Brush-Epithelial-Goblet_1|Bronchial_Brush / Tissue, Lineage and Cell class of Lung Cells from 10X

TMPPE LYPD3 C1orf167 SDC1

7.61e-05159634a8fa49dc2e6ad726d1f4f2b30693fecd1151a485
ToppCellPND14-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-ASMC|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

B3GALNT1 FSTL1 CYP2E1 SBSPON

7.79e-051606348624f101828efd32cdd38a65df8d94d690720a63
ToppCellPND14-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-ASMC-ASMC_mature|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

B3GALNT1 FSTL1 CYP2E1 SBSPON

7.79e-051606349de3dd6b9d4b51314d60b3b01f4132bcfa2dfc18
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1_SST_CXCL14|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SDK2 GRIN3A THSD7B CHRNA7

9.63e-051696346a2ef66d7ff69a92e8c62759482e823a07352440
ToppCellfacs-Brain_Non-Myeloid-Cortex-3m-Lymphocytic-mature_NK_T_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TIGIT PLEKHA7 ADCY7 TEDC1

1.01e-04171634562fc8a422615dbbece67ea49740f0c09bdb9ae3
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1-5_VIP_KCNJ2|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SDK2 THSD7B CHRFAM7A CHRNA7

1.08e-04174634fdadac1eaab2c4a67e4832f0901df22e893add6a
ToppCellASK452-Immune-NK_cell|ASK452 / Donor, Lineage and Cell class of Lung cells from Dropseq

FBXO6 TIGIT ADCY7 NME8

1.08e-04174634b84e6dc1c003a677234ce3a818650ff58a45dd09
ToppCellAT1_cells-SSc-ILD_02|World / lung cells shred on cell class, cell subclass, sample id

FSTL1 SBSPON SPRING1 C1orf167

1.13e-041766344a30bb771297b30926fb98e2b5ec0dbdc46feac7
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_PAX6-Inh_L1_PAX6_CA4|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SDK2 GRIN3A CHRFAM7A CHRNA7

1.18e-0417863408b4a497aca0aeabf4f6a8a55c05b56417b69e78
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

GRIN3A THSD7B CHRFAM7A CHRNA7

1.20e-0417963497ba67a856680f24846244c0b92c886cc0e79537
ToppCelltumor_Lymph_Node_/_Brain-Fibroblasts-Smooth_muscle_cells|Fibroblasts / Location, Cell class and cell subclass

SDK2 SBSPON THSD7B RNF39

1.20e-0417963483506e00fe99b6450efd2f13f716926a0a4b03cd
ToppCellfacs-Lung-EPCAM-3m-Mesenchymal-Myofibroblast|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FSTL1 CYP2E1 SBSPON THSD7B

1.23e-04180634d67d3196e6cc3dcd31023a4dc69310226181d583
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_PAX6-Inh_L1_PAX6_CA4|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SDK2 GRIN3A CHRFAM7A CHRNA7

1.23e-04180634392bc71a69653ba12de31bed4e9357f181094641
ToppCellfacs-Lung-EPCAM-3m-Mesenchymal-pulmonary_interstitial_fibroblast|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FSTL1 CYP2E1 SBSPON THSD7B

1.23e-04180634573308d43425d9fba20787abdb7f8efefc48efb5
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_PAX6|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SDK2 GRIN3A CHRFAM7A CHRNA7

1.25e-041816348fd64404e57c22c204d835fc5626f73554257b19
ToppCellAdult-Mesenchymal-airway_smooth_muscle_cell-D175|Adult / Lineage, Cell type, age group and donor

SDK2 GLRX2 C1orf167 THSD7B

1.28e-04182634ad4d74d8b19976e1ccc3c5ba8013199338cf6fd8
ToppCelldroplet-Lung-nan-21m-Mesenchymal-Myofibroblast|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

B3GALNT1 FSTL1 CYP2E1 THSD7B

1.31e-04183634b153425ab0df1e5fa9b953e1f6d4e8e3dc6621b0
ToppCelldroplet-Lung-nan-21m-Mesenchymal-pulmonary_interstitial_fibroblast|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

B3GALNT1 FSTL1 CYP2E1 THSD7B

1.31e-0418363419e7be1cfdd111bfb840532a6f7c780345dffccf
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L5-6_SST_KLHL14|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

FSTL1 LYPD3 GRIN3A THSD7B

1.31e-04183634439b1d1373b7cc73d65f3b59037a6def7cf8f4ba
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SDK2 THSD7B CHRFAM7A CHRNA7

1.36e-0418563416e9ccea0e3b95d90dc48ef74206c805681dac0b
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_2|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

GRIN3A THSD7B CHRFAM7A CHRNA7

1.36e-04185634bdfa8c284bbc5e85c806327fbb7778cf16242a38
ToppCelldroplet-Marrow-nan-21m-Lymphocytic-precursor_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

B3GALNT1 DDR1 SBSPON SDC1

1.36e-0418563465dcb0a7ee64990a34a87c167b44497107f035ee
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1_VIP_PRSS8|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

THSD7B PLEKHA7 CHRFAM7A CHRNA7

1.36e-041856344c42bd3cd72f91f4d4ebb849069a03761a2cd662
ToppCellAT1_cells-SSc-ILD_01|World / lung cells shred on cell class, cell subclass, sample id

DDR1 FSTL1 SBSPON SDC1

1.42e-04187634f1dda349335e08dbfc8395d373924037f5ad2fd6
ToppCellLPS-antiTNF-Epithelial_alveolar-AT_1-Differentiating_AT2|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

DDR1 SDK2 SBSPON PLEKHA7

1.42e-0418763458d48128547ee3513d0bf7f78e61b76b1c472ca9
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_PAX6|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SDK2 GRIN3A CHRFAM7A CHRNA7

1.42e-04187634d2ffb2f34f07b0dd5d3cb3ee0275f46ebecf4146
ToppCelldroplet-Lung-21m-Mesenchymal-myofibroblast-myofibroblast_cell-pulmonary_interstitial_myofibroblast|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

B3GALNT1 FSTL1 CYP2E1 THSD7B

1.48e-04189634cd42ce4aa217d0bd95e0cc0ba357bdfeb3e55a48
ToppCelldroplet-Lung-21m-Mesenchymal-myofibroblast-myofibroblast_cell|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

B3GALNT1 FSTL1 CYP2E1 THSD7B

1.48e-04189634102501eee7760d5882dec41ea9d00147b3f4fb73
ToppCelldroplet-Lung-21m-Mesenchymal-myofibroblast|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

B3GALNT1 FSTL1 CYP2E1 THSD7B

1.48e-041896346e83bf855d4771885b60bb8992df2f9b508eef97
ToppCellfacs-Lung-nan-3m-Mesenchymal-pulmonary_interstitial_fibroblast|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

B3GALNT1 FSTL1 CYP2E1 SBSPON

1.51e-04190634c7bd087f36321cec61b98657433b4d19d135791f
ToppCellfacs-Lung-nan-3m-Mesenchymal-Myofibroblast|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

B3GALNT1 FSTL1 CYP2E1 SBSPON

1.51e-04190634834218fcc59df5e7e52de154272f3d55d81d0dac
ToppCellBL-critical-LOC-Epithelial-Squamous|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

LYPD3 DIO2 RNF39 SDC1

1.54e-041916343f9b8c4fb72ae6f3167b187e6715c4dcb3159f98
ToppCell3'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_I_pneumocyte-AT1-AT1_L.0.5.2.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SBSPON SPRING1 C1orf167 SDC1

1.54e-04191634a15e34ad7dbf3f2f13d5e23ce3ffb6d08fd1f9f0
ToppCelldroplet-Lung-18m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l17|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

B3GALNT1 FSTL1 DIO2 THSD7B

1.54e-04191634b51e0f5d1b93f526160c904e9091313a5364f3a7
ToppCelldroplet-Lung-LUNG-1m-Mesenchymal-Myofibroblast|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FSTL1 CYP2E1 SBSPON THSD7B

1.54e-041916349d3fa8d8138700640cc7927521c7635299df697d
ToppCellfacs-Lung-3m-Mesenchymal-myofibroblast|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

B3GALNT1 FSTL1 CYP2E1 SBSPON

1.54e-04191634fd8331c7abdd999f55ba43d307945c6abfccbf84
ToppCelldroplet-Lung-LUNG-1m-Mesenchymal-pulmonary_interstitial_fibroblast|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FSTL1 CYP2E1 SBSPON THSD7B

1.54e-04191634d04ed1e04b8cb904237d8e8388fe7740c724237b
ToppCellASK452-Immune-NK_cell|Immune / Donor, Lineage and Cell class of Lung cells from Dropseq

FBXO6 TIGIT ADCY7 NME8

1.57e-04192634f04ee5aaa54c39b7493098fb3d2f78168d6b8060
ToppCellNS-moderate-d_16-33-Epithelial-Squamous|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

CYP2E1 LYPD3 RNF39 SDC1

1.57e-04192634103496f428f59683ac3ae6147682c07c30663724
ToppCelldroplet-Lung-1m-Mesenchymal-myofibroblast-myofibroblast_cell-pulmonary_interstitial_myofibroblast|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

FSTL1 CYP2E1 SBSPON THSD7B

1.60e-041936342b80991e7ba7640f7ab2139d30e4c54d8e533862
ToppCelldroplet-Lung-1m-Mesenchymal-myofibroblast-myofibroblast_cell|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

FSTL1 CYP2E1 SBSPON THSD7B

1.60e-0419363490cfc34c2d0d7c70f071703d35db1d6037961481
ToppCelldroplet-Lung-3m-Mesenchymal-myofibroblast|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

B3GALNT1 FSTL1 CYP2E1 SBSPON

1.64e-04194634c992e3357f4bf3069f8d697803e5785e49a2ef0a
ToppCelldroplet-Lung-3m-Mesenchymal-myofibroblast-myofibroblast_cell-pulmonary_interstitial_myofibroblast|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

B3GALNT1 FSTL1 CYP2E1 SBSPON

1.64e-041946347bf6edefd13047e04665dbe34051ef3f481f85a4
ToppCelldroplet-Lung-3m-Mesenchymal-myofibroblast-myofibroblast_cell|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

B3GALNT1 FSTL1 CYP2E1 SBSPON

1.64e-0419463419e5beae2c1f8bf42cbe618e89810ce7b01a396c
ToppCelldistal-Epithelial-Differentiating_Basal-3|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

DDR1 CYP2E1 LYPD3 SDC1

1.67e-041956343fe6e49a9161fc9e5160251e6932cb5378175a54
ToppCellfacs-Lung-3m-Mesenchymal-myofibroblast-myofibroblast_cell|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

B3GALNT1 FSTL1 CYP2E1 SBSPON

1.67e-04195634c6bb16c0076639c6ddef1a15d8cba44bc29c077d
ToppCelldroplet-Lung-immune-endo-depleted-3m-Mesenchymal-Myofibroblast|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

B3GALNT1 FSTL1 CYP2E1 SBSPON

1.67e-041956343f64e2313ec79a6d5f4013a52722d071172f6c5d
ToppCellnormal_Lung-Epithelial_cells-AT1|normal_Lung / Location, Cell class and cell subclass

DDR1 SBSPON C1orf167 SDC1

1.67e-04195634569d1ebc5a5aa110a2430b096755ae35354040c4
ToppCellfacs-Lung-3m-Mesenchymal-myofibroblast-myofibroblast_cell-pulmonary_interstitial_myofibroblast|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

B3GALNT1 FSTL1 CYP2E1 SBSPON

1.67e-04195634ea89f80d3d7e9f737442f7c1aa1791d277ffc90c
ToppCelldroplet-Lung-immune-endo-depleted-3m-Mesenchymal-pulmonary_interstitial_fibroblast|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

B3GALNT1 FSTL1 CYP2E1 SBSPON

1.67e-041956347a5108335353ac160b684650c5da97d6f7f4dbcf
ToppCellNS-critical-d_16-33-Epithelial-Squamous|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

LYPD3 DIO2 RNF39 SDC1

1.70e-0419663497e16d9833e4083d719ca7058d5fc9b11edb37e3
ToppCelldistal-3-Epithelial-Differentiating_Basal|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

DDR1 CYP2E1 LYPD3 SDC1

1.70e-0419663477635a0f86910c4019d3370e9c8ba41de176bcf3
ToppCelldroplet-Mammary_Gland-nan-21m-Epithelial|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DDR1 SBSPON LYPD3 SDC1

1.74e-04197634f4dad4423384a2a25e064c849ffccf2811573be0
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_no-steroids|BALF-PFMC / Compartment, severity and other cell annotations on 10x 3' data (130k)

DDR1 FSTL1 RNF39 SDC1

1.74e-04197634495bfdb40b640591fbbaaa99f419bb6468cef405
ToppCell5'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_I_pneumocyte|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SBSPON SPRING1 C1orf167 SDC1

1.74e-04197634c9c968e223e7814cd8d22975d849a31b7e0af7aa
ToppCellcritical-Epithelial-Squamous|critical / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

LYPD3 DIO2 RNF39 SDC1

1.74e-04197634eccc80d6ab79c46b10108de1cff3abeacfc105cd
ToppCell5'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_I_pneumocyte-AT1-AT1_L.0.5.0.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SBSPON SPRING1 C1orf167 SDC1

1.74e-04197634734b8db5bb4917c9ce92ed342fe6c22b64b0d3c5
ToppCell5'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_I_pneumocyte-AT1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SBSPON SPRING1 C1orf167 SDC1

1.74e-04197634e344455e62b3fe94bb242dc0db58d19a1d3878c7
ToppCelldistal-1-Epithelial-Basal|1 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

DDR1 LYPD3 RNF39 SDC1

1.74e-0419763425a2ccc98b973611de0d920b1b455d0b40f0d37f
ToppCellBiopsy_IPF-Epithelial-AT1|Biopsy_IPF / Sample group, Lineage and Cell type

SBSPON SPRING1 C1orf167 SDC1

1.77e-0419863475bdecbe111fededf6082b11de18b84ca308ef6d
ToppCellTracheal-10x5prime-Stromal-Peri/Epineurial_-NAF_endoneurial|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

NOX5 SBSPON HPX DIO2

1.77e-041986347a0c4dbc8c99968d42af00a718f4fedc544599ec
ToppCellcellseq-Epithelial-Epithelial_Airway-Basal/Suprabasal|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

DDR1 LYPD3 RNF39 SDC1

1.80e-04199634974f71b56f66243c78f2f297a1540e0e186df530
ToppCellproximal-Epithelial-Alveolar_Epithelial_Type_1-3|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

SBSPON SPRING1 C1orf167 SDC1

1.84e-04200634b652bc73adfdeccbdcd74497ab6e2085e5c95e88
ToppCellNeuronal-Inhibitory-iA-iA_1(SST_PAX6)-PAX6-TSPAN12-L1-2|Neuronal / cells hierarchy compared to all cells using T-Statistic

THSD7B PLEKHA7 CHRFAM7A CHRNA7

1.84e-04200634523d799eb315b33b77e02d5b7db63dad8450c4e1
ToppCellcontrol|World / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

DDR1 LYPD3 CPLANE1 SDC1

1.84e-0420063497f36d2c197e03d93a1fc59949d77ae90f6e6a9a
ToppCellNeuronal-Inhibitory-iA-iA_1(SST_PAX6)-SST-MC4R|Neuronal / cells hierarchy compared to all cells using T-Statistic

GRIN3A THSD7B CHRFAM7A CHRNA7

1.84e-04200634c1797542541747b524c9c22c723d24c8d027d486
ToppCellNeuronal-Inhibitory-iA-iA_1(SST_PAX6)-PAX6-TSPAN12|Neuronal / cells hierarchy compared to all cells using T-Statistic

THSD7B PLEKHA7 CHRFAM7A CHRNA7

1.84e-04200634e5cef95e563a6e793ade190ce88c999bfa0af460
ToppCellNeuronal-Inhibitory-iA-iA_1(SST_PAX6)-PAX6|Neuronal / cells hierarchy compared to all cells using T-Statistic

SDK2 THSD7B CHRFAM7A CHRNA7

1.84e-042006348a8f9d9e5ffab3f736c4bd0a5bb616d442d137d1
ToppCellNeuronal-Inhibitory-iA|Neuronal / cells hierarchy compared to all cells using T-Statistic

DDR1 GRIN3A THSD7B CHRNA7

1.84e-042006345ef4a3dc18a44292184a59ced916183c0699b01e
ToppCelldistal-3-Epithelial-Alveolar_Epithelial_Type_1|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

SBSPON SPRING1 C1orf167 SDC1

1.84e-04200634ff64454a08ae8d4cc6e8f0392558460020844bbc
ToppCellproximal-Epithelial-Alveolar_Epithelial_Type_1|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

SBSPON SPRING1 C1orf167 SDC1

1.84e-04200634c1345893e6947ccf9b41282d0e4428dbfb8bcc27
ToppCellproximal-3-Epithelial-Alveolar_Epithelial_Type_1|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

SBSPON SPRING1 C1orf167 SDC1

1.84e-0420063451f8fc43c069f2c4e75588d28ae6deb5d7ed2c86
ToppCellBronchial-10x5prime-Epithelial-Epi_airway_basal-Suprabasal|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

DDR1 LYPD3 RNF39 SDC1

1.84e-04200634ce969c958a31145bbfe315a9a865d7900ecc9549
ToppCellNS-control|NS / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

DDR1 LYPD3 CPLANE1 SDC1

1.84e-04200634ecbe89ff95d046155b984c8c150e0b9e7278f839
DiseaseWolf-Hirschhorn syndrome (implicated_via_orthology)

LETM2 LETM1

2.27e-054582DOID:0050460 (implicated_via_orthology)
Diseasecognitive disorder (implicated_via_orthology)

CHRFAM7A CHRNA7

5.67e-056582DOID:1561 (implicated_via_orthology)
Diseaserheumatoid arthritis (biomarker_via_orthology)

CHRFAM7A CHRNA7

5.67e-056582DOID:7148 (biomarker_via_orthology)
Diseasenicotine dependence (implicated_via_orthology)

CHRFAM7A CHRNA7

2.47e-0412582DOID:0050742 (implicated_via_orthology)
DiseaseSchizophrenia

DDR1 FSTL1 CYP2E1 GRIN3A CHRFAM7A ADCY7 CHRNA7

1.67e-03883587C0036341
Diseasemitochondrial metabolism disease (implicated_via_orthology)

LETM2 LETM1

2.17e-0335582DOID:700 (implicated_via_orthology)
Diseaseleft ventricular diastolic function measurement

SLC35F1 RNF39

5.09e-0354582EFO_0008204
Diseasealcohol dependence measurement

BPTF DIO2

5.27e-0355582EFO_0007835
Diseaseirritable bowel syndrome symptom measurement

CHRFAM7A CHRNA7

5.85e-0358582EFO_0021536

Protein segments in the cluster

PeptideGeneStartEntry
LLIPRWREARSLSWM

LINC00479

36

Q96M42
WSFSLLIMWLCNRER

ERC2-IT1

111

O76042
LCWALLLWKMRLFQR

C1orf167

786

Q5SNV9
PRWSLWRRVFLMASL

CEACAM18

6

A8MTB9
LLWAMPARWLTHLLR

ALG3

371

Q92685
LLIIALMLWRLHWRR

DDR1

431

Q08345
LMLWRLHWRRLLSKA

DDR1

436

Q08345
ELASMLWRIRWEELQ

NPR2

486

P20594
RWLRALALLTWACLV

ADCY7

91

P51828
VSLMLRLLWASLRWD

BPTF

1906

Q12830
CSLWRDLIDLMTLWK

FBXO6

41

Q9NRD1
TRVILLNWCAWFLRM

CHRNA7

331

P36544
LVWAAFLLLVSMWRQ

CYP2E1

11

P05181
VLMLRRCLTWLRATW

NOX5

286

Q96PH1
WRRMLTSEGLRCVWK

DIO2

51

Q92813
WIDAKVAARMVWRLL

LETM2

141

Q2VYF4
QMIIRWRKLELNCWS

MDN1

3806

Q9NU22
RIWIIHLDMTSERSW

HEMK1

211

Q9Y5R4
RRWWMACTAVLENLL

SLC43A2

11

Q8N370
LWIDTKIAARMLWRI

LETM1

171

O95202
WTVLPSRMSLRSLKW

B3GALNT1

6

O75752
SLASVWLARRMWTLR

METTL9

11

Q9H1A3
WLARRMWTLRSPLTR

METTL9

16

Q9H1A3
ETWRQLWRVLEMSDI

GNL1

176

P36915
MRRRLWLGLAWLLLA

FGF22

1

Q9HCT0
LWALSLLRSILEWMF

MRGPRX3

146

Q96LB0
TRVILLNWCAWFLRM

CHRFAM7A

241

Q494W8
AMIWTAGWLLLLLLR

LYPD3

11

O95274
MRRLSLWWLLSRVCL

GRIN3A

1

Q8TCU5
LLEWMIRWSNRRLLC

CPLANE1

1746

Q9H799
MWKRWLALALALVAV

FSTL1

1

Q12841
VTWELVVLRRMLKEW

HEATR4

451

Q86WZ0
VLWADRLLKMRWSGL

GLB1L

61

Q6UWU2
FWGRENLELSLRIWM

GALNTL5

331

Q7Z4T8
MIWRRAALAGTRLVW

GLRX2

1

Q9NS18
ELWMTLFKWLRLRTV

DPY19L4

506

Q7Z388
MWVCSTLWRVRTPAR

MECR

1

Q9BV79
LDLLAMLVWCISDWR

FDXACB1

491

Q9BRP7
RTASETSLWLRWMPL

SDK2

1106

Q58EX2
RWNEVTRRIEMWISI

KIF13A

981

Q9H1H9
RLHIMAGRRLWWLDL

HPX

371

P02790
AMVWRRLLRKRWVLA

SPRING1

6

Q9H741
WLWSLTSETTLRRLR

TMEM191C

316

A6NGB0
RWLWRHVDLTLYTMR

FBXL12

41

Q9NXK8
SSGMRLWKRRWFVLA

PLEKHA7

176

Q6IQ23
MRRAALWLWLCALAL

SDC1

1

P18827
LWALSLLRSILEWML

MRGPRX1

146

Q96LB2
FTKLSCMWEDIRWLR

ANKFN1

481

Q8N957
SSSWWRVMALILLIL

CLEC1B

26

Q9P126
RLDRLMKWLFWPLLD

CKLF

66

Q9UBR5
MLENWVWDVDSLRRL

NLN

531

Q9BYT8
LLAILRRRWWKYMIL

SLC35F1

121

Q5T1Q4
MAPARLFLSLRLWAW

TVP23C

236

Q96ET8
WMVVRDEKRRWTLDL

ZFP30

66

Q9Y2G7
MILTKWNAVAEWRRL

NME8

521

Q8N427
MRTLWMALCALSRLW

SBSPON

1

Q8IVN8
MDRVLLRWISLFWLT

ILDR2

1

Q71H61
KLRYQLLCSMRWRTW

SPDYE4

196

A6NLX3
RRSELVFWRWMDTVL

TEDC1

316

Q86SX3
MRWCLLLIWAQGLRQ

TIGIT

1

Q495A1
ALSRLRELCRWWLMP

ZKSCAN7

71

Q9P0L1
NLTVTCWVWRSMRKL

THSD7B

6

Q9C0I4
CWVWRSMRKLFLLLS

THSD7B

11

Q9C0I4
MWWRDLTRLRLWLKR

RNF39

1

Q9H2S5
TWRRREMVRWLVSCA

ZSWIM4

686

Q9H7M6
LAESLELRAWRWLLR

TMPPE

31

Q6ZT21