Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	inositol 1,4,5 trisphosphate binding	TRPC7 TRPC6 ITPR1	1.17e-05	14	65	3	GO:0070679
GeneOntologyMolecularFunction	sodium:bicarbonate symporter activity	SLC4A7 SLC4A10	1.55e-04	6	65	2	GO:0008510
GeneOntologyMolecularFunction	ATP-dependent chromatin remodeler activity	CHD3 CHD4 ZRANB3	2.36e-04	37	65	3	GO:0140658
GeneOntologyMolecularFunction	translation initiation factor activity	EIF4E1B EIF3G EIF4G3	6.13e-04	51	65	3	GO:0003743
GeneOntologyMolecularFunction	store-operated calcium channel activity	TRPC7 TRPC6	6.74e-04	12	65	2	GO:0015279
GeneOntologyMolecularFunction	ATP-dependent activity, acting on DNA	WRNIP1 CHD3 CHD4 ZRANB3	7.83e-04	127	65	4	GO:0008094
GeneOntologyMolecularFunction	monoatomic cation:bicarbonate symporter activity	SLC4A7 SLC4A10	7.95e-04	13	65	2	GO:0140410
GeneOntologyMolecularFunction	calcium channel activity	TRPC7 TRPC6 CACNA1I ITPR1	8.30e-04	129	65	4	GO:0005262
GeneOntologyMolecularFunction	clathrin binding	GAK TRPC6 LRRK2	1.14e-03	63	65	3	GO:0030276
GeneOntologyMolecularFunction	calcium ion transmembrane transporter activity	TRPC7 TRPC6 CACNA1I ITPR1	1.49e-03	151	65	4	GO:0015085
GeneOntologyMolecularFunction	helicase activity	WRNIP1 CHD3 CHD4 ZRANB3	1.76e-03	158	65	4	GO:0004386
GeneOntologyCellularComponent	membrane coat	SYNJ1 COPG1 VPS41 COPG2 SEC13	1.83e-05	106	64	5	GO:0030117
GeneOntologyCellularComponent	coated membrane	SYNJ1 COPG1 VPS41 COPG2 SEC13	1.83e-05	106	64	5	GO:0048475
GeneOntologyCellularComponent	dendrite	IL1RAPL1 NSMF ICA1 LRRK2 APBB1 SLC4A10 PLEC ADNP CHRNA5 ITPR1	2.61e-04	858	64	10	GO:0030425
GeneOntologyCellularComponent	dendritic tree	IL1RAPL1 NSMF ICA1 LRRK2 APBB1 SLC4A10 PLEC ADNP CHRNA5 ITPR1	2.66e-04	860	64	10	GO:0097447
GeneOntologyCellularComponent	Golgi-associated vesicle	COPG1 LRRK2 VPS41 COPG2	4.14e-04	114	64	4	GO:0005798
GeneOntologyCellularComponent	COPI vesicle coat	COPG1 COPG2	7.04e-04	13	64	2	GO:0030126
GeneOntologyCellularComponent	eukaryotic translation initiation factor 4F complex	EIF4E1B EIF4G3	7.04e-04	13	64	2	GO:0016281
GeneOntologyCellularComponent	vesicle coat	COPG1 COPG2 SEC13	1.14e-03	67	64	3	GO:0030120
GeneOntologyCellularComponent	somatodendritic compartment	IL1RAPL1 NSMF ICA1 LRRK2 APBB1 SLC4A10 PLEC ADNP CHRNA5 FCHSD1 ITPR1	1.15e-03	1228	64	11	GO:0036477
GeneOntologyCellularComponent	CHD-type complex	CHD3 CHD4	1.22e-03	17	64	2	GO:0090545
GeneOntologyCellularComponent	RNA cap binding complex	EIF4E1B EIF4G3	1.22e-03	17	64	2	GO:0034518
GeneOntologyCellularComponent	NuRD complex	CHD3 CHD4	1.22e-03	17	64	2	GO:0016581
GeneOntologyCellularComponent	axon	IL1RAPL1 NEK3 SYNJ1 LRRK2 APBB1 SLC4A10 COPG2 PLEC ADNP	1.50e-03	891	64	9	GO:0030424
GeneOntologyCellularComponent	COPI-coated vesicle membrane	COPG1 COPG2	1.53e-03	19	64	2	GO:0030663
GeneOntologyCellularComponent	perinuclear region of cytoplasm	GAK TRPC7 SYNJ1 ICA1 WRNIP1 APBB1 EIF3G PLEC ITPR1	2.07e-03	934	64	9	GO:0048471
Domain	Coatomer_g_Cpla	COPG1 COPG2	1.12e-05	2	63	2	IPR032154
Domain	-	COPG1 COPG2	1.12e-05	2	63	2	2.60.40.1480
Domain	Coatomer_gsu	COPG1 COPG2	1.12e-05	2	63	2	IPR017106
Domain	COP-gamma_platf	COPG1 COPG2	1.12e-05	2	63	2	PF08752
Domain	Coatomer_g_Cpla	COPG1 COPG2	1.12e-05	2	63	2	PF16381
Domain	Coatomer_gsu_app_Ig-like-sub	COPG1 COPG2	1.12e-05	2	63	2	IPR013040
Domain	ARM-type_fold	PPP4R3B RSPH14 COPG1 IFT172 LRRK2 COPG2 EIF4G3 ITPR1	1.76e-05	339	63	8	IPR016024
Domain	CHDCT2	CHD3 CHD4	3.35e-05	3	63	2	PF08074
Domain	CHDNT	CHD3 CHD4	3.35e-05	3	63	2	PF08073
Domain	DUF1086	CHD3 CHD4	3.35e-05	3	63	2	IPR009462
Domain	DUF1087	CHD3 CHD4	3.35e-05	3	63	2	IPR009463
Domain	CHD_N	CHD3 CHD4	3.35e-05	3	63	2	IPR012958
Domain	CHD_C2	CHD3 CHD4	3.35e-05	3	63	2	IPR012957
Domain	DUF1087	CHD3 CHD4	3.35e-05	3	63	2	PF06465
Domain	DUF1086	CHD3 CHD4	3.35e-05	3	63	2	PF06461
Domain	DUF1087	CHD3 CHD4	3.35e-05	3	63	2	SM01147
Domain	DUF1086	CHD3 CHD4	3.35e-05	3	63	2	SM01146
Domain	-	COPG1 COPG2	6.69e-05	4	63	2	3.30.310.30
Domain	Clathrin_a/coatomer_app_sub_C	COPG1 COPG2	6.69e-05	4	63	2	IPR015873
Domain	Anion_exchange	SLC4A7 SLC4A10	1.11e-04	5	63	2	IPR001717
Domain	TRP_dom	TRPC7 TRPC6	1.67e-04	6	63	2	IPR013555
Domain	TRP_2	TRPC7 TRPC6	1.67e-04	6	63	2	PF08344
Domain	SNF2_N	CHD3 CHD4 ZRANB3	1.69e-04	32	63	3	IPR000330
Domain	SNF2_N	CHD3 CHD4 ZRANB3	1.69e-04	32	63	3	PF00176
Domain	ANION_EXCHANGER_2	SLC4A7 SLC4A10	2.33e-04	7	63	2	PS00220
Domain	ANION_EXCHANGER_1	SLC4A7 SLC4A10	2.33e-04	7	63	2	PS00219
Domain	TRPC_channel	TRPC7 TRPC6	2.33e-04	7	63	2	IPR002153
Domain	Coatomer/calthrin_app_sub_C	COPG1 COPG2	3.09e-04	8	63	2	IPR009028
Domain	Band3_cytoplasmic_dom	SLC4A7 SLC4A10	3.97e-04	9	63	2	IPR013769
Domain	Band_3_cyto	SLC4A7 SLC4A10	3.97e-04	9	63	2	PF07565
Domain	-	SLC4A7 SLC4A10	3.97e-04	9	63	2	3.40.1100.10
Domain	HCO3_cotransp	SLC4A7 SLC4A10	4.95e-04	10	63	2	PF00955
Domain	HCO3_transpt_C	SLC4A7 SLC4A10	4.95e-04	10	63	2	IPR011531
Domain	PTrfase/Anion_transptr	SLC4A7 SLC4A10	4.95e-04	10	63	2	IPR016152
Domain	HCO3_transpt_euk	SLC4A7 SLC4A10	4.95e-04	10	63	2	IPR003020
Domain	Znf_C2H2/integrase_DNA-bd	ZSCAN29 ZNF131 ZNF765 ZNF618 ZNF616 ZNF510 ZNF468 ZNF606 ADNP	5.04e-04	694	63	9	IPR013087
Domain	Ion_trans_dom	TRPC7 TRPC6 CACNA1I ITPR1	5.94e-04	114	63	4	IPR005821
Domain	Ion_trans	TRPC7 TRPC6 CACNA1I ITPR1	5.94e-04	114	63	4	PF00520
Domain	TRP_channel	TRPC7 TRPC6	6.04e-04	11	63	2	IPR004729
Domain	Coatomer/clathrin_app_Ig-like	COPG1 COPG2	7.23e-04	12	63	2	IPR013041
Domain	ZINC_FINGER_C2H2_2	ZSCAN29 ZNF131 ZNF765 ZNF618 ZNF616 ZNF510 ZNF468 ZNF606 ADNP	1.10e-03	775	63	9	PS50157
Domain	ZINC_FINGER_C2H2_1	ZSCAN29 ZNF131 ZNF765 ZNF618 ZNF616 ZNF510 ZNF468 ZNF606 ADNP	1.13e-03	777	63	9	PS00028
Domain	Clathrin/coatomer_adapt-like_N	COPG1 COPG2	1.14e-03	15	63	2	IPR002553
Domain	Adaptin_N	COPG1 COPG2	1.14e-03	15	63	2	PF01602
Domain	Znf_C2H2-like	ZSCAN29 ZNF131 ZNF765 ZNF618 ZNF616 ZNF510 ZNF468 ZNF606 ADNP	1.33e-03	796	63	9	IPR015880
Domain	Znf_C2H2	ZSCAN29 ZNF131 ZNF765 ZNF618 ZNF616 ZNF510 ZNF468 ZNF606 ADNP	1.44e-03	805	63	9	IPR007087
Domain	ZnF_C2H2	ZSCAN29 ZNF131 ZNF765 ZNF618 ZNF616 ZNF510 ZNF468 ZNF606 ADNP	1.48e-03	808	63	9	SM00355
Domain	HEAT_REPEAT	COPG1 COPG2 EIF4G3	1.70e-03	70	63	3	PS50077
Domain	-	ZSCAN29 ZNF131 ZNF765 ZNF618 ZNF616 ZNF510 ZNF468 ZNF606	1.94e-03	679	63	8	3.30.160.60
Domain	ARM-like	PPP4R3B RSPH14 COPG1 LRRK2 COPG2	2.16e-03	270	63	5	IPR011989
Domain	zf-C2H2	ZSCAN29 ZNF131 ZNF765 ZNF616 ZNF510 ZNF468 ZNF606 ADNP	2.21e-03	693	63	8	PF00096
Domain	Chromo_domain	CHD3 CHD4	2.95e-03	24	63	2	IPR023780
Domain	C2H2_Znf_fam	ZSCAN29 ZNF131	2.95e-03	24	63	2	IPR027775
Domain	Chromo	CHD3 CHD4	3.45e-03	26	63	2	PF00385
Domain	CHROMO_1	CHD3 CHD4	4.00e-03	28	63	2	PS00598
Domain	CHROMO_2	CHD3 CHD4	4.00e-03	28	63	2	PS50013
Domain	Chromodomain-like	CHD3 CHD4	5.20e-03	32	63	2	IPR016197
Domain	Chromo/shadow_dom	CHD3 CHD4	5.53e-03	33	63	2	IPR000953
Domain	CHROMO	CHD3 CHD4	5.53e-03	33	63	2	SM00298
Domain	Helicase_C	CHD3 CHD4 ZRANB3	5.66e-03	107	63	3	PF00271
Domain	HELICc	CHD3 CHD4 ZRANB3	5.66e-03	107	63	3	SM00490
Domain	Helicase_C	CHD3 CHD4 ZRANB3	5.81e-03	108	63	3	IPR001650
Domain	HELICASE_CTER	CHD3 CHD4 ZRANB3	5.96e-03	109	63	3	PS51194
Pathway	REACTOME_ELEVATION_OF_CYTOSOLIC_CA2_LEVELS	TRPC7 TRPC6 ITPR1	1.17e-05	13	50	3	MM14553
Pathway	REACTOME_ELEVATION_OF_CYTOSOLIC_CA2_LEVELS	TRPC7 TRPC6 ITPR1	2.28e-05	16	50	3	M26945
Pathway	REACTOME_EFFECTS_OF_PIP2_HYDROLYSIS	TRPC7 TRPC6 ITPR1	9.14e-05	25	50	3	MM14511
Pathway	REACTOME_EFFECTS_OF_PIP2_HYDROLYSIS	TRPC7 TRPC6 ITPR1	1.16e-04	27	50	3	M12123
Pathway	REACTOME_PLATELET_CALCIUM_HOMEOSTASIS	TRPC7 TRPC6 ITPR1	1.16e-04	27	50	3	MM15053
Pathway	REACTOME_PLATELET_CALCIUM_HOMEOSTASIS	TRPC7 TRPC6 ITPR1	1.29e-04	28	50	3	M924
Pathway	REACTOME_BICARBONATE_TRANSPORTERS	SLC4A7 SLC4A10	5.45e-04	10	50	2	M27335
Pathway	REACTOME_ROLE_OF_SECOND_MESSENGERS_IN_NETRIN_1_SIGNALING	TRPC7 TRPC6	5.45e-04	10	50	2	M27330
Pathway	REACTOME_BICARBONATE_TRANSPORTERS	SLC4A7 SLC4A10	5.45e-04	10	50	2	MM15073
Pubmed	N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.	USP36 EHBP1 ZNF131 GAK SYNJ1 PRRC2C APBB1 COPG2 CHD3 CHD4 EIF3G RRBP1 EIF4G3 ADNP DEPDC1B FTSJ3	2.57e-11	934	68	16	33916271
Pubmed	Comparative proximity biotinylation implicates the small GTPase RAB18 in sterol mobilization and biosynthesis.	EHBP1 TMX1 GAK SLC4A7 COPG1 PRRC2C COPG2 EIF3G RRBP1 GBA2 ITPR1	1.32e-08	568	68	11	37774976
Pubmed	Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.	EHBP1 TMX1 TNRC18 SLC4A7 SYNJ1 COPG1 PRRC2C WRNIP1 APBB1 SLC4A10 PLEC RRBP1 EIF4G3 ITPR1	3.57e-08	1139	68	14	36417873
Pubmed	RSPO-LGR4 functions via IQGAP1 to potentiate Wnt signaling.	GAK PRRC2C CHD3 CHD4 RRBP1 EIF4G3 FTSJ3	1.44e-07	202	68	7	24639526
Pubmed	RNF138 inhibits late inflammatory gene transcription through degradation of SMARCC1 of the SWI/SNF complex.	CHD4 PLEC EIF4G3 ADNP	3.06e-07	29	68	4	36800290
Pubmed	Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.	USP36 SLC4A7 COPG1 LRRK2 APBB1 COPG2 CHD4 EIF4G3 DNAH7 MKS1 SEC13	3.11e-07	777	68	11	35844135
Pubmed	The PHLPP1 N-Terminal Extension Is a Mitotic Cdk1 Substrate and Controls an Interactome Switch.	SLC4A7 PRRC2C COPG2 CHD3 PLEC RRBP1 DEPDC1B	7.13e-07	256	68	7	33397691
Pubmed	Maternal Transient Receptor Potential Vanilloid 6 (Trpv6) Is Involved In Offspring Bone Development.	TRPC7 TRPC6 CACNA1I ITPR1	9.38e-07	38	68	4	30786075
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	EHBP1 ZNF131 SYNJ1 COPG2 CHD3 CHD4 PLEC ADNP	1.60e-06	418	68	8	34709266
Pubmed	Hypertonicity-responsive ubiquitin ligase RNF183 promotes Na, K-ATPase lysosomal degradation through ubiquitination of its β1 subunit.	EHBP1 TMX1 GAK SLC4A7 COPG1 APBB1 COPG2 DEPDC1B	2.72e-06	449	68	8	31732153
Pubmed	Molecular analysis of a major antigenic region of the 240-kD protein of Mi-2 autoantigen.	CHD3 CHD4	3.77e-06	2	68	2	7560064
Pubmed	Chronic continuous hypoxia decreases the expression of SLC4A7 (NBCn1) and SLC4A10 (NCBE) in mouse brain.	SLC4A7 SLC4A10	3.77e-06	2	68	2	17928512
Pubmed	Human R1441C LRRK2 regulates the synaptic vesicle proteome and phosphoproteome in a Drosophila model of Parkinson's disease.	SYNJ1 LRRK2	3.77e-06	2	68	2	27794539
Pubmed	Molecular determinants for cardiovascular TRPC6 channel regulation by Ca2+/calmodulin-dependent kinase II.	TRPC7 TRPC6	3.77e-06	2	68	2	23529130
Pubmed	Mouse Chd4-NURD is required for neonatal spermatogonia survival and normal gonad development.	CHD3 CHD4	3.77e-06	2	68	2	35568926
Pubmed	The major dermatomyositis-specific Mi-2 autoantigen is a presumed helicase involved in transcriptional activation.	CHD3 CHD4	3.77e-06	2	68	2	7575689
Pubmed	Two forms of the major antigenic protein of the dermatomyositis-specific Mi-2 autoantigen.	CHD3 CHD4	3.77e-06	2	68	2	8843877
Pubmed	PLC-mediated PI(4,5)P2 hydrolysis regulates activation and inactivation of TRPC6/7 channels.	TRPC7 TRPC6	3.77e-06	2	68	2	24470487
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	COPG1 PRRC2C COPG2 CHD4 PLEC EIF4G3 ADNP SEC13 FTSJ3	5.04e-06	653	68	9	22586326
Pubmed	Parkinson's Disease-Associated LRRK2 Hyperactive Kinase Mutant Disrupts Synaptic Vesicle Trafficking in Ventral Midbrain Neurons.	SYNJ1 LRRK2	1.13e-05	3	68	2	29054882
Pubmed	The chromatin-remodeling enzyme CHD3 plays a role in embryonic viability but is dispensable for early vascular development.	CHD3 CHD4	1.13e-05	3	68	2	32658897
Pubmed	Genome-wide identification of mouse congenital heart disease loci.	IFT172 MKS1	1.13e-05	3	68	2	20511334
Pubmed	The Retinal Basis of Light Aversion in Neonatal Mice.	TRPC7 TRPC6	1.13e-05	3	68	2	35396331
Pubmed	Interaction of gamma-COP with a transport motif in the D1 receptor C-terminus.	COPG1 COPG2	1.13e-05	3	68	2	11893085
Pubmed	Major contribution of the 3/6/7 class of TRPC channels to myocardial ischemia/reperfusion and cellular hypoxia/reoxygenation injuries.	TRPC7 TRPC6	1.13e-05	3	68	2	28526717
Pubmed	Unbiased Identification of trans Regulators of ADAR and A-to-I RNA Editing.	USP36 CHD3 CHD4 PLEC RRBP1 FTSJ3	1.55e-05	271	68	6	32433965
Pubmed	Characterization of the CHD family of proteins.	CHD3 CHD4	2.25e-05	4	68	2	9326634
Pubmed	Leucine-rich repeat kinase 2 regulates Sec16A at ER exit sites to allow ER-Golgi export.	LRRK2 SEC13	2.25e-05	4	68	2	25201882
Pubmed	Comprehensive research synopsis and systematic meta-analyses in Parkinson's disease genetics: The PDGene database.	GAK LRRK2	2.25e-05	4	68	2	22438815
Pubmed	Melanopsin Phototransduction Is Repurposed by ipRGC Subtypes to Shape the Function of Distinct Visual Circuits.	TRPC7 TRPC6	2.25e-05	4	68	2	30017393
Pubmed	NAB2 represses transcription by interacting with the CHD4 subunit of the nucleosome remodeling and deacetylase (NuRD) complex.	CHD3 CHD4	2.25e-05	4	68	2	16574654
Pubmed	A SCL4A10 gene product maps selectively to the basolateral plasma membrane of choroid plexus epithelial cells.	SLC4A7 SLC4A10	2.25e-05	4	68	2	14592810
Pubmed	Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.	PPP4R3B WRNIP1 CHD4 RRBP1 ADNP ITPR1 FTSJ3	2.47e-05	440	68	7	34244565
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	CNPPD1 PPP4R3B NSMF SYNJ1 IFT172 APBB1 CHD4 PLEC RRBP1 ZNF606 EIF4G3	3.72e-05	1285	68	11	35914814
Pubmed	Spatial proteomics reveal that the protein phosphatase PTP1B interacts with and may modify tyrosine phosphorylation of the rhomboid protease RHBDL4.	EHBP1 TMX1 APBB1 COPG2 RRBP1	3.73e-05	191	68	5	31177093
Pubmed	Immunocytochemical identification of electroneutral Na⁺-coupled HCO₃⁻ transporters in freshly dissociated mouse medullary raphé neurons.	SLC4A7 SLC4A10	3.75e-05	5	68	2	23500099
Pubmed	TRPC channels are necessary mediators of pathologic cardiac hypertrophy.	TRPC7 TRPC6	3.75e-05	5	68	2	20351294
Pubmed	Intrinsic phototransduction persists in melanopsin-expressing ganglion cells lacking diacylglycerol-sensitive TRPC subunits.	TRPC7 TRPC6	3.75e-05	5	68	2	21261756
Pubmed	SMYD3 Impedes Small Cell Lung Cancer Sensitivity to Alkylation Damage through RNF113A Methylation-Phosphorylation Cross-talk.	PPP4R3B TNRC18 PRRC2C CHD3 CHD4 PLEC RRBP1 FTSJ3	4.15e-05	655	68	8	35819319
Pubmed	SARS-CoV-2 Nsp6 damages Drosophila heart and mouse cardiomyocytes through MGA/MAX complex-mediated increased glycolysis.	SEL1L TMX1 COPG1 WRNIP1 COPG2 CHD4 EIF3G RRBP1	4.24e-05	657	68	8	36180527
Pubmed	Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.	ZNF131 SLC4A7 COPG1 PRRC2C WRNIP1 CHD4 RRBP1 ADNP SMAD9	4.31e-05	857	68	9	25609649
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	EHBP1 SLC4A7 SYNJ1 PRRC2C APBB1 PLEC EIF4G3 DNAH7 DEPDC1B	4.47e-05	861	68	9	36931259
Pubmed	Complementary proteomics strategies capture an ataxin-1 interactome in Neuro-2a cells.	COPG1 PRRC2C WRNIP1 COPG2 CHD4 RRBP1 EIF4G3 FTSJ3	4.61e-05	665	68	8	30457570
Pubmed	The RNA binding protein MEX3A promotes tumor progression of breast cancer by post-transcriptional regulation of IGFBP4.	TNRC18 PRRC2C CHD3 CHD4 EIF3G PLEC	4.81e-05	332	68	6	37433992
Pubmed	Early Hearing Loss upon Disruption of Slc4a10 in C57BL/6 Mice.	SLC4A7 SLC4A10	5.62e-05	6	68	2	31001720
Pubmed	Identification and characterization of novel isoforms of COP I subunits.	COPG1 COPG2	5.62e-05	6	68	2	11056392
Pubmed	Association of tapasin and COPI provides a mechanism for the retrograde transport of major histocompatibility complex (MHC) class I molecules from the Golgi complex to the endoplasmic reticulum.	COPG1 COPG2	5.62e-05	6	68	2	11884415
Pubmed	Chromatin remodeling proteins interact with pericentrin to regulate centrosome integrity.	CHD3 CHD4	5.62e-05	6	68	2	17626165
Pubmed	Cross-linking mass spectrometry reveals the structural topology of peripheral NuRD subunits relative to the core complex.	CHD3 CHD4 ADNP	5.74e-05	38	68	3	33283408
Pubmed	N-Terminomics for the Identification of In Vitro Substrates and Cleavage Site Specificity of the SARS-CoV-2 Main Protease.	GAK PRRC2C APBB1 PLEC RRBP1 ADNP	7.52e-05	360	68	6	33111431
Pubmed	MxA, a member of the dynamin superfamily, interacts with the ankyrin-like repeat domain of TRPC.	TRPC7 TRPC6	7.86e-05	7	68	2	15757897
Pubmed	TRPC absence induces pro-inflammatory macrophage polarization to promote obesity and exacerbate colorectal cancer.	TRPC7 TRPC6	7.86e-05	7	68	2	38835669
Pubmed	Coexistence within one cell of microvillous and ciliary phototransductions across M1- through M6-IpRGCs.	TRPC7 TRPC6	7.86e-05	7	68	2	38109525
Pubmed	RNA-seq analysis reveals TRPC genes to impact an unexpected number of metabolic and regulatory pathways.	TRPC7 TRPC6	7.86e-05	7	68	2	32350291
Pubmed	Common genetic variation in the HLA region is associated with late-onset sporadic Parkinson's disease.	GAK LRRK2	7.86e-05	7	68	2	20711177
Pubmed	TRPC absence induces pro-inflammatory macrophages and gut microbe disorder, sensitizing mice to colitis.	TRPC7 TRPC6	7.86e-05	7	68	2	36592529
Pubmed	Leucine-rich repeat kinase 2 interacts with p21-activated kinase 6 to control neurite complexity in mammalian brain.	GAK LRRK2	7.86e-05	7	68	2	26375402
Pubmed	Functional role of TRPC proteins in vivo: lessons from TRPC-deficient mouse models.	TRPC7 TRPC6	7.86e-05	7	68	2	15336983
Pubmed	Subunit composition, molecular environment, and activation of native TRPC channels encoded by their interactomes.	TRPC7 TRPC6	7.86e-05	7	68	2	36257322
Pubmed	Systematic identification of cancer cell vulnerabilities to natural killer cell-mediated immune surveillance.	EHBP1 SYNJ1 JRK COPG2 ZRANB3	8.28e-05	226	68	5	31452512
Pubmed	Protein interaction studies in human induced neurons indicate convergent biology underlying autism spectrum disorders.	EIF3G RRBP1 ADNP	8.34e-05	43	68	3	36950384
Pubmed	Transcription factor Foxp3 and its protein partners form a complex regulatory network.	COPG2 CHD4 PLEC EIF4G3 SEC13 FTSJ3	8.74e-05	370	68	6	22922362
Pubmed	The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.	USP36 ZNF131 PRRC2C COPG2 CHD3 CHD4 RRBP1 ADNP FTSJ3	9.79e-05	954	68	9	36373674
Pubmed	Novel isotypic gamma/zeta subunits reveal three coatomer complexes in mammals.	COPG1 COPG2	1.05e-04	8	68	2	14729954
Pubmed	Subunit composition of mammalian transient receptor potential channels in living cells.	TRPC7 TRPC6	1.05e-04	8	68	2	12032305
Pubmed	Association of immunophilins with mammalian TRPC channels.	TRPC7 TRPC6	1.05e-04	8	68	2	15199065
Pubmed	Mammalian chromodomain proteins: their role in genome organisation and expression.	CHD3 CHD4	1.05e-04	8	68	2	10655032
Pubmed	In vivo assembly of coatomer, the COP-I coat precursor.	COPG1 COPG2	1.05e-04	8	68	2	8940050
Pubmed	ADNP promotes neural differentiation by modulating Wnt/β-catenin signaling.	CHD4 ADNP	1.05e-04	8	68	2	32533114
Pubmed	Metabolism regulates the spontaneous firing of substantia nigra pars reticulata neurons via KATP and nonselective cation channels.	TRPC7 TRPC6	1.05e-04	8	68	2	25471572
Pubmed	Mutations of the Transcriptional Corepressor ZMYM2 Cause Syndromic Urinary Tract Malformations.	ZNF131 CHD3 CHD4 ADNP	1.08e-04	125	68	4	32891193
Pubmed	Overlapping Activities of Two Neuronal Splicing Factors Switch the GABA Effect from Excitatory to Inhibitory by Regulating REST.	NSMF SYNJ1 SLC4A10 ITPR1	1.19e-04	128	68	4	30995482
Pubmed	FOXA1 Directs H3K4 Monomethylation at Enhancers via Recruitment of the Methyltransferase MLL3.	USP36 COPG1 CHD3 CHD4 DNAH7	1.28e-04	248	68	5	27926873
Pubmed	Identification of common binding sites for calmodulin and inositol 1,4,5-trisphosphate receptors on the carboxyl termini of trp channels.	TRPC7 TRPC6	1.34e-04	9	68	2	11290752
Pubmed	A single binding site for dilysine retrieval motifs and p23 within the gamma subunit of coatomer.	COPG1 COPG2	1.34e-04	9	68	2	9751720
Pubmed	Homer binds TRPC family channels and is required for gating of TRPC1 by IP3 receptors.	TRPC6 ITPR1	1.34e-04	9	68	2	14505576
Pubmed	Cellular subtype distribution and developmental regulation of TRPC channel members in the mouse dorsal root ganglion.	TRPC7 TRPC6	1.34e-04	9	68	2	17480026
Pubmed	The WW domain of neural protein FE65 interacts with proline-rich motifs in Mena, the mammalian homolog of Drosophila enabled.	APBB1 CHD3	1.34e-04	9	68	2	9407065
Pubmed	Apical localization of a functional TRPC3/TRPC6-Ca2+-signaling complex in polarized epithelial cells. Role in apical Ca2+ influx.	TRPC6 ITPR1	1.34e-04	9	68	2	15623527
Pubmed	COP I domains required for coatomer integrity, and novel interactions with ARF and ARF-GAP.	COPG1 COPG2	1.34e-04	9	68	2	10921873
Pubmed	The proximal proteome of 17 SARS-CoV-2 proteins links to disrupted antiviral signaling and host translation.	SEL1L EHBP1 TMX1 SLC4A7 SYNJ1 APBB1 COPG2 EIF3G SEC13	1.47e-04	1007	68	9	34597346
Pubmed	The cell proliferation antigen Ki-67 organises heterochromatin.	USP36 ZNF131 JRK BARD1 CHD3 FTSJ3	1.53e-04	410	68	6	26949251
Pubmed	Exploring an Alternative Cysteine-Reactive Chemistry to Enable Proteome-Wide PPI Analysis by Cross-Linking Mass Spectrometry.	COPG1 COPG2 CHD4 EIF3G RRBP1 EIF4G3	1.55e-04	411	68	6	36652389
Pubmed	Functional proteomics mapping of a human signaling pathway.	MAN1C1 VPS41 CHD3 ZNF510 PLEC RRBP1 SMAD9	1.56e-04	591	68	7	15231748
Pubmed	Methyltransferase-like 21e inhibits 26S proteasome activity to facilitate hypertrophy of type IIb myofibers.	SYNJ1 CHD4 EIF3G PLEC RRBP1	1.57e-04	259	68	5	31162944
Pubmed	Heterogeneous distribution of TRPC proteins in the embryonic cortex.	TRPC7 TRPC6	1.68e-04	10	68	2	18989690
Pubmed	The leak channel NALCN controls tonic firing and glycolytic sensitivity of substantia nigra pars reticulata neurons.	TRPC7 TRPC6	1.68e-04	10	68	2	27177420
Pubmed	The discovery of a Werner Helicase Interacting Protein (WHIP) association with the nuclear pore complex.	WRNIP1 SEC13	1.68e-04	10	68	2	20676042
Pubmed	CHD3 and CHD4 form distinct NuRD complexes with different yet overlapping functionality.	USP36 PRRC2C CHD3 CHD4 EIF3G ADNP FTSJ3	1.80e-04	605	68	7	28977666
Pubmed	Jade-1S phosphorylation induced by CK1α contributes to cell cycle progression.	CHD3 CHD4 FTSJ3	1.84e-04	56	68	3	26919559
Pubmed	Mitochondrial phosphoproteome revealed by an improved IMAC method and MS/MS/MS.	TMX1 PLEC ITPR1	1.94e-04	57	68	3	17208939
Pubmed	Synaptic vesicle trafficking and Parkinson's disease.	SYNJ1 LRRK2	2.05e-04	11	68	2	21563316
Pubmed	The Meckel syndrome- associated protein MKS1 functionally interacts with components of the BBSome and IFT complexes to mediate ciliary trafficking and hedgehog signaling.	IFT172 MKS1	2.05e-04	11	68	2	28291807
Pubmed	Ikaros DNA-binding proteins direct formation of chromatin remodeling complexes in lymphocytes.	CHD3 CHD4	2.05e-04	11	68	2	10204490
Pubmed	Two-Dimensional Fractionation Method for Proteome-Wide Cross-Linking Mass Spectrometry Analysis.	PPP4R3B NHSL2 PRRC2C CHD3 CHD4 EIF3G PLEC EIF4G3	2.44e-04	847	68	8	35235311
Pubmed	NuRD suppresses pluripotency gene expression to promote transcriptional heterogeneity and lineage commitment.	CHD3 CHD4	2.45e-04	12	68	2	22560079
Pubmed	Mit1/Lb9 and Copg2, new members of mouse imprinted genes closely linked to Peg1/Mest(1).	COPG1 COPG2	2.45e-04	12	68	2	10788617
Pubmed	Severe neurologic impairment in mice with targeted disruption of the electrogenic sodium bicarbonate cotransporter NBCe2 (Slc4a5 gene).	SLC4A7 SLC4A10	2.45e-04	12	68	2	21705333
Pubmed	NURD, a novel complex with both ATP-dependent chromatin-remodeling and histone deacetylase activities.	CHD3 CHD4	2.45e-04	12	68	2	9885572
Pubmed	The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation.	COPG1 IFT172 WRNIP1 COPG2 CHD4 EIF3G PLEC	2.49e-04	638	68	7	33239621
Interaction	NAA40 interactions	USP36 EHBP1 ZNF131 GAK SYNJ1 PRRC2C APBB1 COPG2 CHD3 CHD4 EIF3G RRBP1 EIF4G3 ADNP DEPDC1B FTSJ3	4.55e-08	978	64	16	int:NAA40
Interaction	SRP68 interactions	USP36 GAK PRRC2C CHD3 CHD4 EIF3G RRBP1 GBA2 FTSJ3	3.09e-06	381	64	9	int:SRP68
Interaction	GJD3 interactions	EHBP1 TMX1 SLC4A7 COPG1 APBB1 RRBP1 DEPDC1B SEC13 ITPR1	1.27e-05	454	64	9	int:GJD3
Interaction	LGR4 interactions	GAK PRRC2C CHD3 CHD4 RRBP1 EIF4G3 FTSJ3	1.91e-05	262	64	7	int:LGR4
Interaction	B3GAT1 interactions	EHBP1 TMX1 SLC4A7 COPG1 APBB1 RRBP1 DEPDC1B ITPR1	2.47e-05	377	64	8	int:B3GAT1
Interaction	SEC61B interactions	SEL1L EHBP1 TMX1 ZNF131 SLC4A7 COPG1 APBB1 COPG2 RRBP1 GBA2 ITPR1	2.54e-05	763	64	11	int:SEC61B
Interaction	EMD interactions	EHBP1 TMX1 SLC4A7 COPG1 APBB1 COPG2 CHD4 RRBP1 ADNP GBA2 ITPR1	3.45e-05	789	64	11	int:EMD
Interaction	PRRC2C interactions	USP36 PRRC2C LRRK2 CHD3 CHD4 EIF3G RRBP1	3.66e-05	290	64	7	int:PRRC2C
Interaction	EBAG9 interactions	EHBP1 GAK SLC4A7 COPG1 APBB1 COPG2 DEPDC1B	4.83e-05	303	64	7	int:EBAG9
Interaction	PHLPP1 interactions	SLC4A7 PRRC2C COPG2 CHD3 PLEC RRBP1 DEPDC1B	8.75e-05	333	64	7	int:PHLPP1
Interaction	DERL1 interactions	SEL1L EHBP1 TMX1 SLC4A7 APBB1 RRBP1 GBA2 ITPR1	9.00e-05	453	64	8	int:DERL1
Interaction	TRPC2 interactions	TRPC6 ITPR1	9.87e-05	5	64	2	int:TRPC2
Interaction	TRPC6 interactions	SEL1L TRPC7 TRPC6 ITPR1	1.34e-04	82	64	4	int:TRPC6
Interaction	TMT1A interactions	EHBP1 TMX1 SLC4A7 APBB1 RRBP1 GBA2 ITPR1	1.39e-04	359	64	7	int:TMT1A
Interaction	BAG2 interactions	USP36 GAK PRRC2C LRRK2 COPG2 CHD4 EIF4G3 ADNP MKS1	1.45e-04	622	64	9	int:BAG2
Interaction	MAN1C1 interactions	MAN1C1 SMAD9	1.48e-04	6	64	2	int:MAN1C1
Interaction	TRPC7 interactions	TRPC7 TRPC6	1.48e-04	6	64	2	int:TRPC7
Interaction	ELOVL5 interactions	TMX1 SLC4A7 COPG1 COPG2 RRBP1 DEPDC1B ITPR1	1.52e-04	364	64	7	int:ELOVL5
Interaction	TRPC3 interactions	TRPC7 TRPC6 ITPR1	1.56e-04	33	64	3	int:TRPC3
Interaction	KDM1A interactions	EHBP1 ZNF131 SYNJ1 JRK COPG2 CHD3 CHD4 PLEC ADNP TTC33 SMAD9	1.66e-04	941	64	11	int:KDM1A
Interaction	HERC2 interactions	GAK COPG1 LRRK2 APBB1 BARD1 COPG2 EIF3G PLEC	1.85e-04	503	64	8	int:HERC2
Interaction	EIF3C interactions	COPG1 CHD3 CHD4 EIF3G EIF4G3 SMAD9	1.86e-04	263	64	6	int:EIF3C
Interaction	SEC62 interactions	EHBP1 TMX1 SLC4A7 COPG1 APBB1 COPG2 RRBP1 ITPR1	1.93e-04	506	64	8	int:SEC62
Interaction	RHBDF2 interactions	EHBP1 TMX1 APBB1 COPG2 RRBP1	1.94e-04	168	64	5	int:RHBDF2
Interaction	RRP1 interactions	USP36 BARD1 CHD3 CHD4 FTSJ3	2.11e-04	171	64	5	int:RRP1
Interaction	BMI1 interactions	PRRC2C CHD3 CHD4 EIF3G PLEC RRBP1 EIF4G3 ADNP FTSJ3	2.24e-04	659	64	9	int:BMI1
Interaction	EIF4EBP1 interactions	EIF4E1B LRRK2 EIF3G EIF4G3	2.28e-04	94	64	4	int:EIF4EBP1
Interaction	TPR interactions	PRRC2C LRRK2 CHD3 CHD4 RRBP1 SEC13	2.65e-04	281	64	6	int:TPR
Interaction	RAB11A interactions	EHBP1 TMX1 SLC4A7 LRRK2 APBB1 EIF3G RRBP1 DEPDC1B SEC13 FTSJ3	2.68e-04	830	64	10	int:RAB11A
Interaction	TMEM17 interactions	EHBP1 TMX1 SLC4A7 COPG1 APBB1 DEPDC1B MKS1	2.87e-04	404	64	7	int:TMEM17
Interaction	LOC102724159 interactions	USP36 CHD4	3.52e-04	9	64	2	int:LOC102724159
Interaction	RACK1 interactions	GAK PRRC2C BARD1 CHD3 CHD4 EIF3G PLEC RRBP1 FTSJ3	3.63e-04	704	64	9	int:RACK1
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZSCAN29 ZNF131 ZNF765 ZNF618 ZNF616 ZNF510 ZNF468 ZNF606	2.51e-04	718	43	8	28
GeneFamily	PHD finger proteins\|NuRD complex	CHD3 CHD4	3.59e-04	12	43	2	1305
GeneFamily	Bardet-Biedl syndrome associated\|BBSome	IFT172 MKS1	1.13e-03	21	43	2	980
GeneFamily	Transient receptor potential cation channels	TRPC7 TRPC6	2.01e-03	28	43	2	249
CoexpressionAtlas	DevelopingGonad_e12.5_epididymis_emap-29139_k-means-cluster#3_top-relative-expression-ranked_1000	TNRC18 SLC4A7 NHSL2 ZNF618 PRRC2C ZNF616 PLEC	1.27e-05	259	64	7	gudmap_developingGonad_e12.5_epididymis_k3_1000
Disease	atrioventricular septal defect (implicated_via_orthology)	IFT172 MKS1	9.36e-05	7	63	2	DOID:0050651 (implicated_via_orthology)
Disease	nicotine dependence (implicated_via_orthology)	TRPC7 TRPC6	2.92e-04	12	63	2	DOID:0050742 (implicated_via_orthology)
Disease	Bardet-Biedl Syndrome	IFT172 MKS1	3.45e-04	13	63	2	C0752166
Disease	Parkinson's disease (implicated_via_orthology)	GAK SYNJ1 VPS41 EIF4G3	3.60e-04	157	63	4	DOID:14330 (implicated_via_orthology)
Disease	anemia (implicated_via_orthology)	SLC4A7 SLC4A10	4.63e-04	15	63	2	DOID:2355 (implicated_via_orthology)
Disease	lung cancer (is_implicated_in)	TRPC7 CHD4 CHRNA5	5.40e-04	74	63	3	DOID:1324 (is_implicated_in)
Disease	gastric ulcer	JRK TTC33	9.18e-04	21	63	2	EFO_0009454
Disease	platelet crit	CNPPD1 SLC4A7 NHSL2 TRPC6 LRRK2 WRNIP1 PLEC RRBP1	9.18e-04	952	63	8	EFO_0007985
Disease	3-hydroxy-1-methylpropylmercapturic acid measurement	SEL1L EHBP1 NHSL2 JRK ITPR1	9.36e-04	352	63	5	EFO_0007015
Disease	vascular endothelial function measurement	EHBP1 ZNF765 ZNF468	1.26e-03	99	63	3	EFO_0803369
Disease	Parkinsonism, Juvenile	SYNJ1 LRRK2	1.88e-03	30	63	2	C0752105
Disease	Ovarian Mucinous Adenocarcinoma	LRRK2 WEE2	2.00e-03	31	63	2	C1335167
Disease	pyridoxate measurement	TRPC6 EMILIN2	2.00e-03	31	63	2	EFO_0010527

Protein segments in the cluster

Peptide	Gene	Start	Entry
EVDQDDVVEWKDGAS	ADNP	956	Q9H2P0
SWADQVEEEGEDDKC	EIF3G	11	O75821
QKWNLEAEKEDGEFD	BARD1	216	Q99728
EKWDEEAQDAAGEEE	CT47B1	266	P0C2W7
EDIKGKWGEEDFEDN	DEPDC1B	86	Q8WUY9
FEDGEFWKDEPSDEA	APBB1	311	O00213
KWDEEAQDAAGEEEK	CT47A1	256	Q5JQC4
WNDDGDAVIIDKDLF	HSFX4	101	A0A1B0GTS1
NALEAGEDEEEVWLF	ITPR1	686	Q14643
GGIREWEEEEKEEEA	EIF4E1B	11	A6NMX2
GEKFIEDLDENRVWE	IL1RAPL1	286	Q9NZN1
EGEEVAWEQAAVAFD	JRK	481	O75564
QENDDEGEEDKLFWL	LRRK2	336	Q5S007
AFEDLDWDTEKGLEA	NSMF	321	Q6X4W1
WFNEDEEEEGKAVVA	PPP4R3B	716	Q5MIZ7
WNDDGDAVIIDKDLF	HSFX3	101	A0A1B0GWH4
FEEEDDNPDWVSELK	NEK3	481	P51956
VKEAIDAFIEGEEWN	IFT172	1361	Q9UG01
EVIEEGDADEWVKAR	FCHSD1	496	Q86WN1
DWQEEKEAETGAENA	GAK	796	O14976
DVDKRDFFDNGEWEI	CHRNA5	206	P30532
DEGEEEEVFNDEWGA	CNPPD1	136	Q9BV87
FVWDVENEGDEALDV	GBA2	271	Q9HCG7
EGVQWEAKEEEEEYE	CHD3	426	Q12873
GKEEEEEEQADGAVW	CACNA1I	606	Q9P0X4
EVFPEEWEDKANEFQ	DNAH7	3366	Q8WXX0
YVVAAEEVWDDEQKD	GJB4	36	Q9NTQ9
AAWEEVGDTFEKEET	COPG2	771	Q9UBF2
EEFEDKEWTFVIENE	EHBP1	91	Q8NDI1
ELKEEFQEAKAWVGE	MAN1C1	231	Q9NR34
NFEAAWDEVGDEFEK	COPG1	771	Q9Y678
WDEVGDEFEKEETFT	COPG1	776	Q9Y678
EPDVDFDAKWNELDA	EMILIN2	441	Q9BXX0
WEAKEDNSEGEEILE	CHD4	421	Q14839
EDKANDEQIFDWVEA	EIF4G3	1436	O43432
EEGEFSKEWAAVFGD	ICA1	386	Q05084
EEEDGQWKEEQKLEA	SEC13	196	P55735
ETARWLKFEEDVEDG	SLC4A7	131	Q9Y6M7
WVTFEEEEDFGVKGK	SYNJ1	1481	O43426
ADEKWGFCETEEEAA	SEL1L	161	Q9UBV2
KTAEWIAEDDDDVFV	NHSL2	1091	Q5HYW2
SWEEAEAAGEIDVAE	GUCA1B	6	Q9UMX6
DKFDNLDAEADEGWA	PRRC2C	306	Q9Y520
EDEGELPEWFVQEEK	FTSJ3	696	Q8IY81
WTKDGEDIEEDDRVF	SPEGNB	181	A0A087WV53
QGDEEEKWAEKAVDS	SMAD9	26	O15198
EEDEEFLKDEWPAQG	TNRC18	1736	O15417
DLEFQWKDGETNDKE	ZNF616	96	Q08AN1
VKESWAEEADFEPAA	ZNF618	836	Q5T7W0
EEEQVWRAKVGAAEE	RRBP1	1151	Q9P2E9
DEEEEIVIGWQEKLF	MKS1	71	Q9NXB0
WKLQVEVEEEEFQEF	RSPH14	156	Q9UHP6
ETARWLKFEEDVEDG	SLC4A10	136	Q6U841
EKEEEEVGFDWSDRN	PLEC	771	Q15149
FAKEQDDGELWEDLI	VPS41	686	P49754
SWDEAEAQEEEEAVG	WRNIP1	156	Q96S55
FKLEQGEEPWFSEEE	ZNF510	96	Q9Y2H8
DKDIHDIEFQWQEDE	ZNF765	91	Q7L2R6
SGVIEEVENEADWFL	WEE2	356	P0C1S8
IQGEEEANDVWKAAE	ZNF131	96	P52739
FQEIEDDADVEWKFA	TRPC6	731	Q9Y210
VEQDHWSFEDEKVAG	ZSCAN29	231	Q8IWY8
EWGEDLEVNIAKVDV	TMX1	71	Q9H3N1
EKDIHGFEFQWKEDE	ZNF468	91	Q5VIY5
ETVVDDWDEEFDRGK	USP36	1066	Q9P275
DVAVDFTQEEWGQLD	ZNF606	66	Q8WXB4
YQEIEEDADVEWKFA	TRPC7	676	Q9HCX4
EGDKEKWDFLQFAEA	ZRANB3	481	Q5FWF4
AADEKDVVDNDEGNW	TTC33	26	Q6PID6