Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionprotein-cysteine S-palmitoyltransferase activity

ZDHHC2 ZDHHC21 ZDHHC7 ZDHHC20 ZDHHC15 ZDHHC12 ZDHHC3 ZDHHC16

3.52e-1626438GO:0019706
GeneOntologyMolecularFunctionprotein-cysteine S-acyltransferase activity

ZDHHC2 ZDHHC21 ZDHHC7 ZDHHC20 ZDHHC15 ZDHHC12 ZDHHC3 ZDHHC16

3.52e-1626438GO:0019707
GeneOntologyMolecularFunctionS-acyltransferase activity

ZDHHC2 ZDHHC21 ZDHHC7 ZDHHC20 ZDHHC15 ZDHHC12 ZDHHC3 ZDHHC16

1.31e-1530438GO:0016417
GeneOntologyMolecularFunctionpalmitoyltransferase activity

ZDHHC2 ZDHHC21 ZDHHC7 ZDHHC20 ZDHHC15 ZDHHC12 ZDHHC3 ZDHHC16

8.55e-1537438GO:0016409
GeneOntologyMolecularFunctionprotein-cysteine S-myristoyltransferase activity

ZDHHC2 ZDHHC7 ZDHHC20 ZDHHC15 ZDHHC3

2.18e-136435GO:0019705
GeneOntologyMolecularFunctionprotein-cysteine S-stearoyltransferase activity

ZDHHC2 ZDHHC7 ZDHHC20 ZDHHC15 ZDHHC3

7.62e-137435GO:0140439
GeneOntologyMolecularFunctionmyristoyltransferase activity

ZDHHC2 ZDHHC7 ZDHHC20 ZDHHC15 ZDHHC3

1.67e-1111435GO:0019107
GeneOntologyMolecularFunctionacyltransferase activity, transferring groups other than amino-acyl groups

ZDHHC2 ZDHHC21 ZDHHC7 ZDHHC20 ZDHHC15 ZDHHC12 ZDHHC3 ZDHHC16

3.66e-08238438GO:0016747
GeneOntologyMolecularFunctionvoltage-gated sodium channel activity

SCN2A SCN4A SCN8A SCN9A

2.69e-0726434GO:0005248
GeneOntologyMolecularFunctionsodium ion binding

SCN2A SCN8A SCN9A

3.33e-0614433GO:0031402
GeneOntologyMolecularFunctionsodium channel activity

SCN2A SCN4A SCN8A SCN9A

4.68e-0652434GO:0005272
GeneOntologyMolecularFunctionfolic acid receptor activity

FOLR1 FOLR3

1.36e-053432GO:0061714
GeneOntologyMolecularFunctionalkali metal ion binding

SCN2A SCN8A SCN9A

2.34e-0526433GO:0031420
GeneOntologyMolecularFunctionacyltransferase activity

ZDHHC2 ZDHHC21 ZDHHC7 ZDHHC20 ZDHHC15 ZDHHC12 RNF31 ZDHHC3 ZDHHC16

3.28e-05775439GO:0016746
GeneOntologyMolecularFunctionsodium ion transmembrane transporter activity

SCN2A SCN4A SCN8A SCN9A

4.94e-04171434GO:0015081
GeneOntologyMolecularFunctioncargo receptor activity

LRP2 FOLR1 FOLR3

8.12e-0485433GO:0038024
GeneOntologyMolecularFunctionfolic acid binding

FOLR1 FOLR3

8.40e-0420432GO:0005542
GeneOntologyBiologicalProcessprotein palmitoylation

ZDHHC2 ZDHHC21 ZDHHC7 ZDHHC20 ZDHHC15 ZDHHC12 ZDHHC3 ZDHHC16

2.39e-1533438GO:0018345
GeneOntologyBiologicalProcesspeptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine

ZDHHC2 ZDHHC21 ZDHHC7 ZDHHC20 ZDHHC15 ZDHHC12 ZDHHC3

3.45e-1424437GO:0018231
GeneOntologyBiologicalProcesspeptidyl-L-cysteine S-palmitoylation

ZDHHC2 ZDHHC21 ZDHHC7 ZDHHC20 ZDHHC15 ZDHHC12 ZDHHC3

3.45e-1424437GO:0018230
GeneOntologyBiologicalProcessprotein targeting to membrane

ZDHHC2 ZDHHC21 ZDHHC7 ZDHHC20 ZDHHC15 ZDHHC12 FYN ZDHHC3 FOLR1 FOLR3

4.46e-131494310GO:0006612
GeneOntologyBiologicalProcesspeptidyl-cysteine modification

ZDHHC2 ZDHHC21 ZDHHC7 ZDHHC20 ZDHHC15 ZDHHC12 ZDHHC3

9.57e-1250437GO:0018198
GeneOntologyBiologicalProcessprotein lipidation

ZDHHC2 ZDHHC21 ZDHHC7 ZDHHC20 ZDHHC15 ZDHHC12 ZDHHC3 ZDHHC16

3.14e-11101438GO:0006497
GeneOntologyBiologicalProcesslipoprotein biosynthetic process

ZDHHC2 ZDHHC21 ZDHHC7 ZDHHC20 ZDHHC15 ZDHHC12 ZDHHC3 ZDHHC16

4.65e-11106438GO:0042158
GeneOntologyBiologicalProcessprotein acylation

ZDHHC2 ZDHHC21 ZDHHC7 ZDHHC20 ZDHHC15 ZDHHC12 ZDHHC3 ZDHHC16

5.41e-11108438GO:0043543
GeneOntologyBiologicalProcessprotein targeting

ZDHHC2 ZDHHC21 ZDHHC7 ZDHHC20 ZDHHC15 ZDHHC12 RNF31 FYN ZDHHC3 FOLR1 FOLR3

2.00e-103734311GO:0006605
GeneOntologyBiologicalProcesslipoprotein metabolic process

ZDHHC2 ZDHHC21 ZDHHC7 ZDHHC20 ZDHHC15 ZDHHC12 ZDHHC3 ZDHHC16

6.45e-10147438GO:0042157
GeneOntologyBiologicalProcessestablishment of protein localization to membrane

ZDHHC2 ZDHHC21 ZDHHC7 ZDHHC20 ZDHHC15 ZDHHC12 FYN ZDHHC3 FOLR1 FOLR3

8.30e-103194310GO:0090150
GeneOntologyBiologicalProcessprotein localization to membrane

WDR19 ZDHHC2 ZDHHC21 ZDHHC7 ZDHHC20 ZDHHC15 ZDHHC12 FYN ZDHHC3 FOLR1 FOLR3

1.46e-077054311GO:0072657
GeneOntologyBiologicalProcesslocalization within membrane

WDR19 ZDHHC2 ZDHHC21 ZDHHC7 ZDHHC20 ZDHHC15 ZDHHC12 FYN ZDHHC3 FOLR1 FOLR3

5.02e-077984311GO:0051668
GeneOntologyBiologicalProcessmembrane depolarization during action potential

SCN2A SCN4A SCN8A SCN9A

9.19e-0736434GO:0086010
GeneOntologyBiologicalProcessfolic acid transport

LRP2 FOLR1 FOLR3

1.38e-0611433GO:0015884
GeneOntologyBiologicalProcessprotein localization to organelle

WDR19 LRP2 TARDBP ZDHHC15 NF1 RNF31 ATRX FYN ZDHHC3 FOLR1 FOLR3 TAX1BP1

1.51e-0610914312GO:0033365
GeneOntologyBiologicalProcessforebrain development

SLITRK5 LRP2 NF1 ATRX FYN SCN2A WDR62 ZDHHC16

6.59e-06489438GO:0030900
GeneOntologyBiologicalProcesscardiac muscle cell action potential involved in contraction

SCN2A SCN4A SCN8A SCN9A

8.36e-0662434GO:0086002
GeneOntologyBiologicalProcessneuronal action potential

SCN2A SCN4A SCN8A SCN9A

8.92e-0663434GO:0019228
GeneOntologyBiologicalProcesscardiac muscle cell action potential

SCN2A SCN4A SCN8A SCN9A

3.21e-0587434GO:0086001
GeneOntologyBiologicalProcesscardiac muscle cell contraction

SCN2A SCN4A SCN8A SCN9A

4.18e-0593434GO:0086003
GeneOntologyBiologicalProcessmyelination

NF1 FYN SCN2A SCN8A TG

6.69e-05206435GO:0042552
GeneOntologyBiologicalProcessaxon ensheathment

NF1 FYN SCN2A SCN8A TG

7.17e-05209435GO:0008366
GeneOntologyBiologicalProcessensheathment of neurons

NF1 FYN SCN2A SCN8A TG

7.17e-05209435GO:0007272
GeneOntologyBiologicalProcessestablishment of protein localization to organelle

LRP2 TARDBP ZDHHC15 NF1 RNF31 FOLR1 FOLR3

8.59e-05515437GO:0072594
GeneOntologyBiologicalProcesstransmission of nerve impulse

SCN2A SCN4A SCN8A SCN9A

8.63e-05112434GO:0019226
GeneOntologyBiologicalProcessmodified amino acid transport

LRP2 FOLR1 FOLR3

1.05e-0444433GO:0072337
GeneOntologyBiologicalProcessregulation of synaptic transmission, GABAergic

ZDHHC12 NF1 ZDHHC3

1.13e-0445433GO:0032228
GeneOntologyBiologicalProcessdicarboxylic acid transport

LRP2 NF1 FOLR1 FOLR3

1.13e-04120434GO:0006835
GeneOntologyBiologicalProcessmembrane depolarization

SCN2A SCN4A SCN8A SCN9A

1.17e-04121434GO:0051899
GeneOntologyBiologicalProcessactin-mediated cell contraction

SCN2A SCN4A SCN8A SCN9A

1.40e-04127434GO:0070252
GeneOntologyBiologicalProcessregulation of translational termination

JMJD4 SHFL

1.51e-049432GO:0006449
GeneOntologyBiologicalProcessvitamin transport

LRP2 FOLR1 FOLR3

2.17e-0456433GO:0051180
GeneOntologyBiologicalProcessprotein localization to cell junction

ZDHHC2 ZDHHC7 ZDHHC15 ZDHHC12

2.53e-04148434GO:1902414
GeneOntologyBiologicalProcessactin filament-based movement

SCN2A SCN4A SCN8A SCN9A

2.87e-04153434GO:0030048
GeneOntologyBiologicalProcessbrain development

SLITRK5 LRP2 NF1 ATRX FYN SCN2A WDR62 ZDHHC16

3.47e-04859438GO:0007420
GeneOntologyBiologicalProcesscardiac muscle contraction

SCN2A SCN4A SCN8A SCN9A

4.00e-04167434GO:0060048
GeneOntologyBiologicalProcessheart process

FYN SCN2A SCN4A SCN8A SCN9A

4.41e-04309435GO:0003015
GeneOntologyBiologicalProcessinnate immune response-activating signaling pathway

ZDHHC12 FYN ZDHHC3 KLRC4 TAX1BP1

4.61e-04312435GO:0002758
GeneOntologyBiologicalProcesspostsynapse organization

ZDHHC2 ZDHHC15 ZDHHC12 NF1 FYN

4.68e-04313435GO:0099173
GeneOntologyBiologicalProcesssynaptic transmission, GABAergic

ZDHHC12 NF1 ZDHHC3

4.93e-0474433GO:0051932
GeneOntologyBiologicalProcesshead development

SLITRK5 LRP2 NF1 ATRX FYN SCN2A WDR62 ZDHHC16

5.45e-04919438GO:0060322
GeneOntologyBiologicalProcesstranslational termination

JMJD4 SHFL

5.66e-0417432GO:0006415
GeneOntologyBiologicalProcesstelencephalon development

SLITRK5 NF1 SCN2A WDR62 ZDHHC16

6.11e-04332435GO:0021537
GeneOntologyBiologicalProcessactivation of innate immune response

ZDHHC12 FYN ZDHHC3 KLRC4 TAX1BP1

6.19e-04333435GO:0002218
GeneOntologyBiologicalProcesscirculatory system process

LRP2 ZDHHC21 FYN SCN2A SCN4A SCN8A SCN9A

7.35e-04733437GO:0003013
GeneOntologyBiologicalProcesspositive regulation of synaptic transmission, GABAergic

ZDHHC12 ZDHHC3

7.88e-0420432GO:0032230
GeneOntologyBiologicalProcessaction potential

SCN2A SCN4A SCN8A SCN9A

8.02e-04201434GO:0001508
GeneOntologyBiologicalProcesspeptidyl-amino acid modification

ZDHHC2 ZDHHC21 ZDHHC7 ZDHHC20 ZDHHC15 ZDHHC12 FYN ZDHHC3

8.09e-04976438GO:0018193
GeneOntologyBiologicalProcessneural tube development

WDR19 LRP2 NF1 FOLR1

8.17e-04202434GO:0021915
GeneOntologyBiologicalProcesspost-translational protein targeting to endoplasmic reticulum membrane

FOLR1 FOLR3

8.69e-0421432GO:0006620
GeneOntologyBiologicalProcesssodium ion transmembrane transport

SCN2A SCN4A SCN8A SCN9A

9.11e-04208434GO:0035725
GeneOntologyBiologicalProcessartery morphogenesis

LRP2 NF1 FOLR1

9.31e-0492433GO:0048844
GeneOntologyBiologicalProcessimmune response-activating signaling pathway

ZDHHC12 RNF31 FYN ZDHHC3 KLRC4 TAX1BP1

9.48e-04553436GO:0002757
GeneOntologyBiologicalProcessstimulatory C-type lectin receptor signaling pathway

FYN KLRC4

1.04e-0323432GO:0002223
GeneOntologyBiologicalProcesscellular response to lectin

FYN KLRC4

1.04e-0323432GO:1990858
GeneOntologyBiologicalProcessresponse to lectin

FYN KLRC4

1.04e-0323432GO:1990840
GeneOntologyBiologicalProcessstriated muscle contraction

SCN2A SCN4A SCN8A SCN9A

1.07e-03217434GO:0006941
GeneOntologyBiologicalProcesstranscytosis

LRP2 TG

1.14e-0324432GO:0045056
GeneOntologyBiologicalProcessSertoli cell development

FNDC3A ATRX

1.14e-0324432GO:0060009
GeneOntologyBiologicalProcesspositive regulation of defense response

ZDHHC12 RNF31 FYN ZDHHC3 KLRC4 TAX1BP1

1.31e-03589436GO:0031349
GeneOntologyBiologicalProcesspositive regulation of synaptic transmission

ZDHHC2 ZDHHC12 NF1 ZDHHC3

1.39e-03233434GO:0050806
GeneOntologyBiologicalProcessmuscle contraction

ZDHHC21 SCN2A SCN4A SCN8A SCN9A

1.40e-03400435GO:0006936
GeneOntologyBiologicalProcessinnate immune response activating cell surface receptor signaling pathway

FYN KLRC4 TAX1BP1

1.44e-03107433GO:0002220
GeneOntologyBiologicalProcesspositive regulation of establishment of protein localization

ZDHHC2 LRP2 TARDBP RNF31 FYN

1.45e-03403435GO:1904951
GeneOntologyBiologicalProcesssensory perception of mechanical stimulus

LRP2 FYN SCN8A SCN9A

1.50e-03238434GO:0050954
GeneOntologyBiologicalProcessimmune response-regulating signaling pathway

ZDHHC12 RNF31 FYN ZDHHC3 KLRC4 TAX1BP1

1.63e-03615436GO:0002764
GeneOntologyBiologicalProcesslipoprotein localization

LRP2 ZDHHC3

1.66e-0329432GO:0044872
GeneOntologyBiologicalProcesssynaptic vesicle maturation

ZDHHC20 ZDHHC15

1.66e-0329432GO:0016188
GeneOntologyBiologicalProcessintracellular receptor signaling pathway

ZDHHC7 ZDHHC12 KMT2D ZDHHC3 TAX1BP1

1.67e-03416435GO:0030522
GeneOntologyBiologicalProcesspositive regulation of innate immune response

ZDHHC12 FYN ZDHHC3 KLRC4 TAX1BP1

1.74e-03420435GO:0045089
GeneOntologyBiologicalProcessactivation of immune response

ZDHHC12 RNF31 FYN ZDHHC3 KLRC4 TAX1BP1

1.75e-03623436GO:0002253
GeneOntologyBiologicalProcessprotein localization to synapse

ZDHHC2 ZDHHC15 ZDHHC12

1.77e-03115433GO:0035418
GeneOntologyBiologicalProcessregulation of response to biotic stimulus

ZDHHC12 RNF31 FYN ZDHHC3 KLRC4 TAX1BP1

2.05e-03643436GO:0002831
GeneOntologyBiologicalProcessfusion of sperm to egg plasma membrane involved in single fertilization

FOLR1 FOLR3

2.15e-0333432GO:0007342
GeneOntologyBiologicalProcessSertoli cell differentiation

FNDC3A ATRX

2.15e-0333432GO:0060008
GeneOntologyBiologicalProcesspositive regulation of response to biotic stimulus

ZDHHC12 FYN ZDHHC3 KLRC4 TAX1BP1

2.37e-03451435GO:0002833
GeneOntologyBiologicalProcessmodulation of chemical synaptic transmission

ZDHHC2 SLITRK5 ZDHHC12 NF1 FYN ZDHHC3

2.39e-03663436GO:0050804
GeneOntologyBiologicalProcessregulation of trans-synaptic signaling

ZDHHC2 SLITRK5 ZDHHC12 NF1 FYN ZDHHC3

2.41e-03664436GO:0099177
GeneOntologyBiologicalProcessregulation of cytoplasmic pattern recognition receptor signaling pathway

ZDHHC12 ZDHHC3 TAX1BP1

2.46e-03129433GO:0039531
GeneOntologyBiologicalProcesssodium ion transport

SCN2A SCN4A SCN8A SCN9A

2.54e-03275434GO:0006814
GeneOntologyBiologicalProcessheart formation

LRP2 FOLR1

2.56e-0336432GO:0060914
GeneOntologyBiologicalProcessregulation of establishment of protein localization

ZDHHC2 LRP2 TARDBP NF1 RNF31 FYN

2.59e-03674436GO:0070201
GeneOntologyBiologicalProcessartery development

LRP2 NF1 FOLR1

2.68e-03133433GO:0060840
GeneOntologyBiologicalProcessplasma membrane fusion

FOLR1 FOLR3

2.70e-0337432GO:0045026
GeneOntologyBiologicalProcessregulation of neural precursor cell proliferation

LRP2 NF1 WDR62

2.79e-03135433GO:2000177
GeneOntologyBiologicalProcesssynapse organization

ZDHHC2 SLITRK5 ZDHHC15 ZDHHC12 NF1 FYN

2.81e-03685436GO:0050808
GeneOntologyBiologicalProcesscentral nervous system development

SLITRK5 LRP2 NF1 ATRX FYN SCN2A WDR62 ZDHHC16

2.96e-031197438GO:0007417
GeneOntologyCellularComponentvoltage-gated sodium channel complex

SCN2A SCN4A SCN8A SCN9A

3.62e-0817434GO:0001518
GeneOntologyCellularComponentsodium channel complex

SCN2A SCN4A SCN8A SCN9A

3.55e-0729434GO:0034706
GeneOntologyCellularComponentGolgi membrane

ZDHHC2 ZDHHC21 ZDHHC7 ZDHHC20 FNDC3A ZDHHC15 ZDHHC12 ZDHHC3 FOLR1 DOP1A

1.53e-067214310GO:0000139
GeneOntologyCellularComponentpostsynaptic density

ZDHHC2 SLITRK5 USP6 ZDHHC15 FYN SCN8A

3.02e-04451436GO:0014069
GeneOntologyCellularComponentasymmetric synapse

ZDHHC2 SLITRK5 USP6 ZDHHC15 FYN SCN8A

4.08e-04477436GO:0032279
GeneOntologyCellularComponentpostsynaptic specialization

ZDHHC2 SLITRK5 USP6 ZDHHC15 FYN SCN8A

5.39e-04503436GO:0099572
GeneOntologyCellularComponentneuron to neuron synapse

ZDHHC2 SLITRK5 USP6 ZDHHC15 FYN SCN8A

6.62e-04523436GO:0098984
GeneOntologyCellularComponentnode of Ranvier

SCN2A SCN8A

7.67e-0420432GO:0033268
GeneOntologyCellularComponentcation channel complex

SCN2A SCN4A SCN8A SCN9A

1.36e-03235434GO:0034703
GeneOntologyCellularComponentaxon initial segment

SCN2A SCN8A

1.62e-0329432GO:0043194
HumanPhenoComplex febrile seizure

SCN2A SCN8A SCN9A

1.39e-0516163HP:0011172
HumanPhenoPes valgus

WDR19 SCN2A SCN4A SCN9A

2.16e-0556164HP:0008081
HumanPhenoFocal hemiclonic seizure

SCN2A SCN8A SCN9A

5.61e-0525163HP:0006813
HumanPhenoNeonatal electro-clinical non-motor seizure

SCN2A SCN8A

9.20e-055162HP:0032812
HumanPhenoNeonatal seizure with electrographic correlate

SCN2A SCN8A

9.20e-055162HP:0032808
HumanPhenoNeonatal electro-clinical seizure

SCN2A SCN8A

9.20e-055162HP:0032809
HumanPhenoNeonatal electro-clinical seizure with behavior arrest

SCN2A SCN8A

9.20e-055162HP:0032823
HumanPhenoFocal head nodding automatism seizure

SCN2A SCN8A

9.20e-055162HP:0032906
HumanPhenoNormal interictal EEG

SCN2A SCN8A

1.38e-046162HP:0002372
HumanPhenoGeneralized clonic seizure

SCN2A SCN8A SCN9A

1.43e-0434163HP:0011169
HumanPhenoDermatological manifestations of systemic disorders

KMT2D ATRX SCN2A SCN4A SCN8A TG SCN9A

1.83e-04435167HP:0001005
HumanPhenoEyelid myoclonia seizure

SCN2A SCN8A

1.92e-047162HP:0032678
HumanPhenoDecreased proportion of memory T cells

KMT2D RNF31

1.92e-047162HP:0032183
HumanPhenoPhotosensitive myoclonic seizure

SCN2A SCN9A

2.56e-048162HP:0001327
HumanPhenoCyanotic episode

SCN2A SCN9A

2.56e-048162HP:0200048
HumanPhenoReduced impulse control

ZMYM2 TARDBP NF1 ATRX KLRC4 SCN2A WDR62 SCN4A SCN8A SCN9A

2.70e-0410321610HP:5200045
HumanPhenoFocal clonic seizure

SCN2A SCN8A SCN9A

2.71e-0442163HP:0002266
HumanPhenoAbnormal proportion of memory T cells

KMT2D RNF31

3.29e-049162HP:0032182
HumanPhenoFlushing

NF1 ATRX SCN9A

3.79e-0447163HP:0031284
HumanPhenoAbnormal atrioventricular valve physiology

KMT2D NF1 ATRX KLRC4 SCN4A

3.81e-04215165HP:0031650
HumanPhenoCyanosis

SCN2A SCN4A SCN8A SCN9A

3.89e-04117164HP:0000961
HumanPhenoWeak cry

KMT2D ATRX SCN4A

4.29e-0449163HP:0001612
HumanPhenoNeonatal seizure

SCN2A SCN8A

5.00e-0411162HP:0032807
HumanPhenoLimited neck range of motion

SCN2A SCN9A

5.00e-0411162HP:0000466
HumanPhenoBilateral tonic-clonic seizure with focal onset

KMT2D SCN2A SCN8A

5.12e-0452163HP:0007334
HumanPhenoRenal hypoplasia/aplasia

WDR19 ZMYM2 KMT2D NF1 ATRX WDR62

5.13e-04359166HP:0008678
HumanPhenoFocal impaired awareness seizure

KMT2D SCN2A SCN8A SCN9A

5.16e-04126164HP:0002384
HumanPhenoRestricted or repetitive behaviors or interests

ZMYM2 TARDBP ATRX SCN2A SCN8A SCN9A

5.86e-04368166HP:0031432
HumanPhenoFocal motor seizure

KMT2D SCN2A SCN8A SCN9A

5.98e-04131164HP:0011153
HumanPhenoEpilepsia partialis continua

SCN2A SCN9A

5.99e-0412162HP:0012847
HumanPhenoFocal automatism seizure

SCN2A SCN8A

5.99e-0412162HP:0032898
HumanPhenoPerseverative thought

ZMYM2 TARDBP ATRX SCN2A SCN8A SCN9A

6.68e-04377166HP:0030223
HumanPhenoAbnormal nervous system electrophysiology

TARDBP KMT2D NF1 ATRX SCN2A WDR62 SCN4A SCN8A SCN9A

6.89e-04924169HP:0001311
HumanPhenoGeneralized cerebral atrophy/hypoplasia

SCN2A SCN9A

7.07e-0413162HP:0007058
HumanPhenoDisordered formal thought process

ZMYM2 TARDBP ATRX SCN2A SCN8A SCN9A

7.58e-04386166HP:0025769
HumanPhenoAbnormal nasal tip morphology

LRP2 ZMYM2 KMT2D NF1 ATRX WDR62

7.58e-04386166HP:0000436
HumanPhenoVisual impairment

WDR19 LRP2 KMT2D NF1 ATRX KLRC4 SCN2A SCN4A SCN8A SCN9A

8.17e-0411741610HP:0000505
HumanPhenoAbnormal cry

KMT2D ATRX SCN4A

8.19e-0461163HP:0025429
HumanPhenoSlanting of the palpebral fissure

LRP2 ZMYM2 KMT2D NF1 ATRX WDR62 SCN4A SCN8A

8.25e-04739168HP:0200006
HumanPhenoBilateral tonic-clonic seizure

KMT2D ATRX SCN2A WDR62 SCN8A SCN9A

8.45e-04394166HP:0002069
HumanPhenoAbnormality of the abdominal wall

WDR19 LRP2 KMT2D NF1 ATRX SCN2A TG

8.78e-04560167HP:0004298
HumanPhenoGeneralized tonic seizure

SCN2A SCN8A SCN9A

9.43e-0464163HP:0010818
HumanPhenoFacial tics

SCN2A SCN9A

9.48e-0415162HP:0011468
HumanPhenoPhotosensitive tonic-clonic seizure

SCN2A SCN9A

9.48e-0415162HP:0007207
HumanPhenoAbnormal thought pattern

ZMYM2 TARDBP ATRX SCN2A SCN8A SCN9A

9.66e-04404166HP:5200269
HumanPhenoImpulsivity

SCN2A WDR62 SCN8A SCN9A

9.72e-04149164HP:0100710
Domainzf-DHHC

ZDHHC2 ZDHHC21 ZDHHC7 ZDHHC20 ZDHHC15 ZDHHC12 ZDHHC3 ZDHHC16

1.89e-1623438PF01529
DomainDHHC

ZDHHC2 ZDHHC21 ZDHHC7 ZDHHC20 ZDHHC15 ZDHHC12 ZDHHC3 ZDHHC16

4.16e-1625438PS50216
DomainZnf_DHHC_palmitoyltrfase

ZDHHC2 ZDHHC21 ZDHHC7 ZDHHC20 ZDHHC15 ZDHHC12 ZDHHC3 ZDHHC16

4.16e-1625438IPR001594
DomainNa_channel_asu

SCN2A SCN4A SCN8A SCN9A

5.06e-0910434IPR001696
DomainNa_trans_assoc

SCN2A SCN4A SCN8A SCN9A

5.06e-0910434IPR010526
DomainNa_trans_assoc

SCN2A SCN4A SCN8A SCN9A

5.06e-0910434PF06512
DomainNa_trans_cytopl

SCN2A SCN8A SCN9A

2.26e-076433PF11933
DomainNa_trans_cytopl

SCN2A SCN8A SCN9A

2.26e-076433IPR024583
DomainChannel_four-helix_dom

SCN2A SCN4A SCN8A SCN9A

8.80e-0657434IPR027359
Domain-

SCN2A SCN4A SCN8A SCN9A

8.80e-06574341.20.120.350
DomainIQ

SCN2A SCN4A SCN8A SCN9A

3.56e-0581434SM00015
DomainFolate_rcpt

FOLR1 FOLR3

5.15e-055432IPR004269
DomainIQ_motif_EF-hand-BS

SCN2A SCN4A SCN8A SCN9A

5.39e-0590434IPR000048
DomainIQ

SCN2A SCN4A SCN8A SCN9A

6.13e-0593434PS50096
DomainIon_trans_dom

SCN2A SCN4A SCN8A SCN9A

1.35e-04114434IPR005821
DomainIon_trans

SCN2A SCN4A SCN8A SCN9A

1.35e-04114434PF00520
DomainFolate_rcpt-like

FOLR1 FOLR3

1.44e-048432IPR018143
DomainFolate_rec

FOLR1 FOLR3

1.44e-048432PF03024
DomainIQ

SCN4A SCN8A SCN9A

5.83e-0471433PF00612
DomainEphrin_rec_like

EPHA8 TG

1.50e-0325432SM01411
DomainTyr-kin_ephrin_A/B_rcpt-like

EPHA8 TG

1.50e-0325432IPR011641
PathwayREACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS

SCN2A SCN4A SCN8A SCN9A

8.47e-0731344M877
PathwayREACTOME_PHASE_0_RAPID_DEPOLARISATION

SCN2A SCN4A SCN8A SCN9A

9.67e-0732344M27455
PathwayREACTOME_MATURATION_OF_SPIKE_PROTEIN

ZDHHC2 ZDHHC20 ZDHHC3

9.42e-0537343M41728
PathwayREACTOME_L1CAM_INTERACTIONS

SCN2A SCN4A SCN8A SCN9A

1.96e-04121344M872
PathwayREACTOME_CARDIAC_CONDUCTION

SCN2A SCN4A SCN8A SCN9A

2.58e-04130344M27454
PathwayREACTOME_TRANSLATION_OF_SARS_COV_2_STRUCTURAL_PROTEINS

ZDHHC2 ZDHHC20 ZDHHC3

3.43e-0457343M41730
PathwayREACTOME_LATE_SARS_COV_2_INFECTION_EVENTS

ZDHHC2 ZDHHC20 ZDHHC3

6.28e-0470343M46438
PathwayREACTOME_EPHA_MEDIATED_GROWTH_CONE_COLLAPSE

FYN EPHA8

8.43e-0418342MM15023
Pubmed

Analysis of substrate specificity of human DHHC protein acyltransferases using a yeast expression system.

ZDHHC2 ZDHHC21 ZDHHC7 ZDHHC20 ZDHHC15 ZDHHC12 ZDHHC3 ZDHHC16

3.49e-201643823034182
Pubmed

Intracellular localization and tissue-specific distribution of human and yeast DHHC cysteine-rich domain-containing proteins.

ZDHHC2 ZDHHC21 ZDHHC7 ZDHHC20 ZDHHC15 ZDHHC12 ZDHHC3

2.02e-162043716647879
Pubmed

Palmitoylation of SARS-CoV-2 Envelope protein is central to virus particle formation.

ZDHHC20 ZDHHC15 ZDHHC12 ZDHHC3

1.01e-11543439287388
Pubmed

Molecular basis of fatty acid selectivity in the zDHHC family of S-acyltransferases revealed by click chemistry.

ZDHHC2 ZDHHC7 ZDHHC15 ZDHHC3

1.01e-11543428167757
Pubmed

Identification of PSD-95 palmitoylating enzymes.

ZDHHC2 ZDHHC7 ZDHHC20 ZDHHC15 ZDHHC3

1.39e-111743515603741
Pubmed

International Union of Pharmacology. XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channels.

SCN2A SCN4A SCN8A SCN9A

2.54e-10943416382098
Pubmed

S-acylation of SARS-CoV-2 spike protein: Mechanistic dissection, in vitro reconstitution and role in viral infectivity.

ZDHHC2 ZDHHC20 ZDHHC3

1.76e-09343334428449
Pubmed

The gamma2 subunit of GABA(A) receptors is a substrate for palmitoylation by GODZ.

ZDHHC21 ZDHHC7 ZDHHC3

7.04e-09443315229235
Pubmed

Palmitoylation and membrane interactions of the neuroprotective chaperone cysteine-string protein.

ZDHHC7 ZDHHC15 ZDHHC3

1.76e-08543318596047
Pubmed

Structure/function characterization of micro-conotoxin KIIIA, an analgesic, nearly irreversible blocker of mammalian neuronal sodium channels.

SCN2A SCN4A SCN8A

1.76e-08543317724025
Pubmed

A 'toothache tree' alkylamide inhibits Aδ mechanonociceptors to alleviate mechanical pain.

SCN2A SCN8A SCN9A

3.51e-08643323652591
Pubmed

Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.

ZDHHC2 ZDHHC21 ZMYM2 JMJD4 ZDHHC7 ZDHHC20 ZDHHC12 ZNF236 ZDHHC3 ZDHHC16

4.15e-08808431020412781
Pubmed

Expression pattern of neuronal and skeletal muscle voltage-gated Na+ channels in the developing mouse heart.

SCN2A SCN4A SCN8A

1.47e-07943315746173
Pubmed

Regulation of neuronal voltage-gated sodium channels by the ubiquitin-protein ligases Nedd4 and Nedd4-2.

SCN2A SCN8A SCN9A

4.99e-071343315123669
Pubmed

State- and use-dependent block of muscle Nav1.4 and neuronal Nav1.7 voltage-gated Na+ channel isoforms by ranolazine.

SCN4A SCN9A

1.49e-06243218079277
Pubmed

Commonalities and distinctions between two neurodevelopmental disorder subtypes associated with SCN2A and SCN8A variants and literature review.

SCN2A SCN8A

1.49e-06243235348308
Pubmed

Electrophysiological properties of two axonal sodium channels, Nav1.2 and Nav1.6, expressed in mouse spinal sensory neurones.

SCN2A SCN8A

1.49e-06243215760941
Pubmed

Oligomerization of DHHC protein S-acyltransferases.

ZDHHC2 ZDHHC3

1.49e-06243223793055
Pubmed

Sodium channel expression within chronic multiple sclerosis plaques.

SCN2A SCN8A

1.49e-06243217805013
Pubmed

Dissociation of Golgi-associated DHHC-type Zinc Finger Protein (GODZ)- and Sertoli Cell Gene with a Zinc Finger Domain-β (SERZ-β)-mediated Palmitoylation by Loss of Function Analyses in Knock-out Mice.

ZDHHC7 ZDHHC3

1.49e-06243227875292
Pubmed

Megalin (gp330): a putative endocytic receptor for thyroglobulin (Tg).

LRP2 TG

1.49e-0624329492085
Pubmed

Sodium channel slow inactivation interferes with open channel block.

SCN8A SCN9A

1.49e-06243227174182
Pubmed

Reduced expression of Na(v)1.6 sodium channels and compensation by Na(v)1.2 channels in mice heterozygous for a null mutation in Scn8a.

SCN2A SCN8A

1.49e-06243218601978
Pubmed

FGF14 N-terminal splice variants differentially modulate Nav1.2 and Nav1.6-encoded sodium channels.

SCN2A SCN8A

1.49e-06243219465131
Pubmed

Nav1.7 is phosphorylated by Fyn tyrosine kinase which modulates channel expression and gating in a cell type-dependent manner.

FYN SCN9A

1.49e-06243229790812
Pubmed

Phosphorylation at Tyr-838 in the kinase domain of EphA8 modulates Fyn binding to the Tyr-615 site by enhancing tyrosine kinase activity.

FYN EPHA8

1.49e-06243210498895
Pubmed

Block of a subset of sodium channels exacerbates experimental autoimmune encephalomyelitis.

SCN2A SCN8A

1.49e-06243223735284
Pubmed

Voltage-gated sodium channels in taste bud cells.

SCN2A SCN9A

4.48e-06343219284629
Pubmed

Aph2, a protein with a zf-DHHC motif, interacts with c-Abl and has pro-apoptotic activity.

ZDHHC2 ZDHHC16

4.48e-06343212021275
Pubmed

Increased expression and characterization of two distinct folate binding proteins in murine erythroleukemia cells.

FOLR1 FOLR3

4.48e-0634328304978
Pubmed

Characterization of two cDNAs encoding folate-binding proteins from L1210 murine leukemia cells. Increased expression associated with a genomic rearrangement.

FOLR1 FOLR3

4.48e-0634321894617
Pubmed

Identification of amino acid residues that determine the differential ligand specificities of folate receptors alpha and beta.

FOLR1 FOLR3

4.48e-0634329166787
Pubmed

DHHC7 Palmitoylates Glucose Transporter 4 (Glut4) and Regulates Glut4 Membrane Translocation.

ZDHHC7 ZDHHC3

4.48e-06343228057756
Pubmed

Variable patterns of mutation density among NaV1.1, NaV1.2 and NaV1.6 point to channel-specific functional differences associated with childhood epilepsy.

SCN2A SCN8A

4.48e-06343232845893
Pubmed

Where is the spike generator of the cochlear nerve? Voltage-gated sodium channels in the mouse cochlea.

SCN2A SCN8A

4.48e-06343216033895
Pubmed

Role of sodium channel subtype in action potential generation by neocortical pyramidal neurons.

SCN2A SCN8A

4.48e-06343229991598
Pubmed

Human voltage-gated sodium channel mutations that cause inherited neuronal and muscle channelopathies increase resurgent sodium currents.

SCN4A SCN9A

4.48e-06343220038812
Pubmed

Comparison and optimization of in silico algorithms for predicting the pathogenicity of sodium channel variants in epilepsy.

SCN2A SCN8A

4.48e-06343228518218
Pubmed

Renal tubular reabsorption of folate mediated by folate binding protein 1.

FOLR1 FOLR3

4.48e-06343215703271
Pubmed

Developmental consequences of in utero sodium arsenate exposure in mice with folate transport deficiencies.

FOLR1 FOLR3

4.48e-06343215694460
Pubmed

Reduced sodium current in Purkinje neurons from Nav1.1 mutant mice: implications for ataxia in severe myoclonic epilepsy in infancy.

SCN2A SCN8A

4.48e-06343217928448
Pubmed

Expression patterns of folate binding proteins one and two in the developing mouse embryo.

FOLR1 FOLR3

4.48e-0634329973545
Pubmed

Mice lacking the folic acid-binding protein Folbp1 are defective in early embryonic development.

FOLR1 FOLR3

4.48e-06343210508523
Pubmed

Experimental and computational evidence that Calpain-10 binds to the carboxy terminus of NaV1.2 and NaV1.6.

SCN2A SCN8A

4.48e-06343238514708
Pubmed

Expression of alternatively spliced sodium channel alpha-subunit genes. Unique splicing patterns are observed in dorsal root ganglia.

SCN8A SCN9A

4.48e-06343215302875
Pubmed

Nav1.1 localizes to axons of parvalbumin-positive inhibitory interneurons: a circuit basis for epileptic seizures in mice carrying an Scn1a gene mutation.

SCN2A SCN8A

8.94e-06443217537961
Pubmed

Growing Mouse Oocytes Transiently Activate Folate Transport via Folate Receptors As They Approach Full Size.

FOLR1 FOLR3

8.94e-06443227122634
Pubmed

Sodium channel expression and transcript variation in the developing brain of human, Rhesus monkey, and mouse.

SCN2A SCN8A

8.94e-06443235031483
Pubmed

Abnormal changes in voltage-gated sodium channels subtypes NaV1.1, NaV1.2, NaV1.3, NaV1.6 and CaM/CaMKII pathway in low-grade astrocytoma.

SCN2A SCN8A

8.94e-06443229578003
Pubmed

Neuronal voltage-gated ion channels are genetic modifiers of generalized epilepsy with febrile seizures plus.

SCN2A SCN8A

8.94e-06443221156207
Pubmed

Identification of two putative novel folate receptor genes in humans and mouse.

FOLR1 FOLR3

8.94e-06443211111049
Pubmed

Dorsal root ganglia isolated from Nf1+/- mice exhibit increased levels of mRNA expression of voltage-dependent sodium channels.

NF1 SCN9A

8.94e-06443222260870
Pubmed

Identification of G protein alpha subunit-palmitoylating enzyme.

ZDHHC7 ZDHHC3

8.94e-06443219001095
Pubmed

Mutations in folate transporter genes and risk for human myelomeningocele.

FOLR1 FOLR3

8.94e-06443228948692
Pubmed

Association of folate receptor (FOLR1, FOLR2, FOLR3) and reduced folate carrier (SLC19A1) genes with meningomyelocele.

FOLR1 FOLR3

8.94e-06443220683905
Pubmed

Palmitoylation regulates epidermal homeostasis and hair follicle differentiation.

ZDHHC21 ZDHHC15 FYN

1.03e-053443319956733
Pubmed

Interaction between the transcriptional corepressor Sin3B and voltage-gated sodium channels modulates functional channel expression.

SCN2A SCN8A

1.49e-05543224077057
Pubmed

A new sodium channel alpha-subunit gene (Scn9a) from Schwann cells maps to the Scn1a, Scn2a, Scn3a cluster of mouse chromosome 2.

SCN2A SCN9A

1.49e-0554328812438
Pubmed

Early development of electrical excitability in the mouse enteric nervous system.

SCN8A SCN9A

1.49e-05543222875929
Pubmed

NLRP3 Cys126 palmitoylation by ZDHHC7 promotes inflammasome activation.

ZDHHC7 ZDHHC3

1.49e-05543238583156
Pubmed

Histone methyltransferase DOT1L coordinates AR and MYC stability in prostate cancer.

TARDBP MMS19 KMT2D RNF31 TAX1BP1

1.85e-0526443532814769
Pubmed

Contactin regulates the current density and axonal expression of tetrodotoxin-resistant but not tetrodotoxin-sensitive sodium channels in DRG neurons.

SCN8A SCN9A

2.23e-05643216029194
Pubmed

The Golgi S-acylation machinery comprises zDHHC enzymes with major differences in substrate affinity and S-acylation activity.

ZDHHC7 ZDHHC3

2.23e-05643225253725
Pubmed

Are voltage-dependent ion channels involved in the endothelial cell control of vasomotor tone?

SCN2A SCN8A

2.23e-05643217513486
Pubmed

DHHC-7 and -21 are palmitoylacyltransferases for sex steroid receptors.

ZDHHC21 ZDHHC7

2.23e-05643222031296
Pubmed

Folate transport in mouse cumulus-oocyte complexes and preimplantation embryos.

FOLR1 FOLR3

2.23e-05643223904512
Pubmed

Diagnostic yield of genetic testing in epileptic encephalopathy in childhood.

SCN2A SCN8A

3.12e-05743225818041
Pubmed

In silico screening for palmitoyl substrates reveals a role for DHHC1/3/10 (zDHHC1/3/11)-mediated neurochondrin palmitoylation in its targeting to Rab5-positive endosomes.

ZDHHC7 ZDHHC3

3.12e-05743223687301
Pubmed

Spatial and temporal expression of folate-related transporters and metabolic enzymes during mouse placental development.

FOLR1 FOLR3

4.16e-05843222365888
Pubmed

The DNA sequence and analysis of human chromosome 13.

SLITRK5 ZMYM2 ZDHHC20 FNDC3A

5.86e-0517043415057823
Pubmed

LRP2 mediates folate uptake in the developing neural tube.

LRP2 FOLR1

8.15e-051143224639464
Pubmed

An atlas of combinatorial transcriptional regulation in mouse and man.

ZDHHC2 ZMYM2 TARDBP ZDHHC15 MMS19 ZNF236 ZDHHC16

9.24e-0587743720211142
Pubmed

Local anesthetics impair the growth and self-renewal of glioblastoma stem cells by inhibiting ZDHHC15-mediated GP130 palmitoylation.

LRP2 ZDHHC15 MTMR12

9.49e-057143333541421
Pubmed

Nav1.2 haplodeficiency in excitatory neurons causes absence-like seizures in mice.

SCN2A SCN8A

9.78e-051243230175250
Pubmed

A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.

LRP2 PDIA5 USP6 RNF31 FYN ZDHHC3

9.80e-0560843616713569
Pubmed

WAVE1 is required for oligodendrocyte morphogenesis and normal CNS myelination.

SCN2A SCN8A

1.15e-041343216723544
Pubmed

Regulation of the linear ubiquitination of STAT1 controls antiviral interferon signaling.

SLITRK5 RNF31

1.35e-041443232123171
Pubmed

Kv7/KCNQ potassium channels in cortical hyperexcitability and juvenile seizure-related death in Ank2-mutant mice.

SCN2A SCN8A

2.26e-041843237321992
Pubmed

The nuclear interactome of DYRK1A reveals a functional role in DNA damage repair.

KMT2D NF1 WDR62

3.11e-0410643331024071
Pubmed

DNA segments mapped by reciprocal use of microsatellite primers between mouse and rat.

SCN2A TG

4.40e-04254328268655
Pubmed

Atrx deficiency induces telomere dysfunction, endocrine defects, and reduced life span.

ATRX TG

4.40e-042543223563309
Pubmed

Oral facial clefts and gene polymorphisms in metabolism of folate/one-carbon and vitamin A: a pathway-wide association study.

FOLR1 FOLR3

5.93e-042943219048631
Pubmed

Comparative interactome analysis of α-arrestin families in human and Drosophila.

ZMYM2 MMS19 NF1 RNF31

6.02e-0431343438270169
Pubmed

Proteomic analysis and identification of cellular interactors of the giant ubiquitin ligase HERC2.

FNDC3A KMT2D WDR62

6.86e-0413943325476789
Pubmed

Large-scale analysis of ion channel gene expression in the mouse heart during perinatal development.

SCN4A SCN8A SCN9A

6.86e-0413943316985003
Pubmed

Functional proteomics mapping of a human signaling pathway.

ZMYM2 KMT2D ATRX ZDHHC3 TAX1BP1

7.87e-0459143515231748
Pubmed

MKRN2 Physically Interacts with GLE1 to Regulate mRNA Export and Zebrafish Retinal Development.

ZMYM2 ATRX FYN EPHA8

9.93e-0435843432460013
Pubmed

Linking functions: an additional role for an intrinsically disordered linker domain in the transcriptional coactivator CBP.

ZMYM2 ATRX

1.02e-033843228680062
Pubmed

TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.

WDR19 ZMYM2 USP6 KMT2D NF1

1.11e-0363843531182584
GeneFamilyZinc fingers DHHC-type|Ankyrin repeat domain containing

ZDHHC2 ZDHHC21 ZDHHC7 ZDHHC20 ZDHHC15 ZDHHC12 ZDHHC3 ZDHHC16

3.54e-172433876
GeneFamilySodium voltage-gated channel alpha subunits

SCN2A SCN4A SCN8A SCN9A

1.15e-0993341203
GeneFamilyX-linked mental retardation|Angiotensin receptors

ZDHHC15 ATRX

4.20e-0353332103
CoexpressionGSE27291_0H_VS_7D_STIM_GAMMADELTA_TCELL_DN

ZMYM2 TARDBP NF1 SHFL SCN9A

1.46e-05190435M8457
DrugAPETx1, Anthopleura elegantissima

SCN2A SCN4A SCN8A

1.25e-076433ctd:C475726
DrugPiretanide [55837-27-9]; Up 200; 11uM; PC3; HT_HG-U133A

NF1 FYN ZNF652 SCN2A WDR62 SCN4A

1.76e-061964364490_UP
Drugmu-conotoxin KIIIA, Conus kinoshitai

SCN2A SCN4A

3.48e-062432ctd:C502265
DrugZonisamide

SCN2A SCN4A SCN9A

4.19e-0617433DB00909
DrugScorpion Venoms

SCN2A SCN4A SCN9A

5.02e-0618433ctd:D012604
DrugN-(2-methyl-3-(4-(4-(4-(trifluoromethoxy)benzyloxy)piperidin-1-yl)-1,3,5-triazin-2-ylamino)phenyl)acetamide

SCN4A SCN9A

1.04e-053432ctd:C561228
DrugMulticide

SCN2A SCN4A SCN9A

1.40e-0525433CID000024365
DrugHC toxin from Helminthosporium carbonum; Up 200; 0.1uM; MCF7; HT_HG-U133A_EA

WDR19 FYN SHFL FOLR1 GEM

1.92e-05175435909_UP
DrugFospropofol

SCN2A SCN4A

2.09e-054432DB06716
DrugLY233053

FNDC3A FOLR3

2.09e-054432CID000130475
DrugAPETx2 protein, Anthopleura elegantissima

SCN2A SCN8A

2.09e-054432ctd:C501880
DrugPropofol

SCN2A SCN4A

2.09e-054432DB00818
DrugKetanserin tartrate hydrate [83846-83-7]; Down 200; 7uM; PC3; HT_HG-U133A

PPP1R3D NF1 RNF31 ATRX FYN

2.79e-051894356649_DN
DrugTolazamide [1156-19-0]; Up 200; 12.8uM; MCF7; HT_HG-U133A

LRP2 NF1 ZNF236 SHFL ZNF652

3.08e-051934352842_UP
Drugalpha-Santonin [481-06-1]; Up 200; 16.2uM; PC3; HT_HG-U133A

ZNF236 WDR62 SCN4A DOP1A SCN8A

3.16e-051944354531_UP
DrugAcenocoumarol [152-72-7]; Up 200; 11.4uM; MCF7; HT_HG-U133A

NF1 ATRX SHFL ZNF652 SCN8A

3.32e-051964352240_UP
DrugHydrocortisone base [50-23-7]; Down 200; 11uM; PC3; HT_HG-U133A

WDR19 PPP1R3D ZMYM2 ATRX WDR62

3.32e-051964356684_DN
DrugMerbromin [129-16-8]; Down 200; 5uM; PC3; HT_HG-U133A

SLITRK5 LRP2 NF1 WDR62 SCN8A

3.48e-051984353700_DN
DrugRiboflavine [83-88-5]; Up 200; 10.6uM; PC3; HT_HG-U133A

LRP2 ZNF236 SCN2A WDR62 SCN8A

3.56e-051994354485_UP
Drugbenzocaine

SCN2A SCN4A SCN9A

4.66e-0537433CID000002337
Drugsipatrigine

SCN2A SCN4A SCN9A

4.66e-0537433CID000060803
DrugTetrodotoxin

SCN2A SCN8A SCN9A

5.90e-0540433ctd:D013779
DrugTG12

TARDBP TG

7.27e-057432CID011972112
Drugfluorocyclobutane

SCN2A SCN4A

7.27e-057432CID011051569
Drug2,3,5,6-tetrafluoro-4-methylbenzyl (Z)-(1RS)-cis-3-(2-chloro-3,3,3-trifluoroprop-1-enyl)-2,2-dimethylcyclopropanecarboxylate

SCN2A SCN8A

9.69e-058432ctd:C489827
DrugAC1NSN3X

KLRC4 SCN4A SCN9A

1.46e-0454433CID005366189
DrugBursin

ZDHHC2 TG

1.55e-0410432CID000194104
DrugRH-3421

SCN4A SCN9A

1.90e-0411432CID000108039
Drugchloroacetylajmaline

SCN4A SCN9A

1.90e-0411432CID000038681
Drugmethylglucamine

SCN4A SCN8A SCN9A

2.20e-0462433CID000004049
DrugRo 22-9194

SCN4A SCN9A

2.27e-0412432CID000129209
DrugProscillaridin A [466-06-8]; Up 200; 7.6uM; MCF7; HT_HG-U133A

ZMYM2 NF1 ZNF236 GEM

2.46e-041624347340_UP
Drugsaxitoxin

SCN2A SCN4A SCN9A

2.53e-0465433CID000037165
DrugCID6432355

SCN4A SCN9A

2.68e-0413432CID006432355
Drug20(S)-Propanaxidiol

SCN2A SCN4A

2.68e-0413432CID005317623
DrugAC1LCJM3

SCN4A SCN9A

2.68e-0413432CID000631640
DrugTrichostatin A, from Streptomyces sp.; Up 200; 0.1uM; MCF7; HT_HG-U133A

WDR19 FYN SHFL GEM

2.88e-041694343868_UP
DrugTrichostatin A, from Streptomyces sp.; Up 200; 0.1uM; PC3; HT_HG-U133A

WDR19 FYN GEM DOP1A

2.88e-041694341793_UP
DrugTrichostatin A, Streptomyces sp.; Up 200; 1uM; MCF7; HT_HG-U133A_EA

WDR19 FYN SHFL GEM

2.95e-041704341014_UP
DrugTrichostatin A, from Streptomyces sp.; Up 200; 0.1uM; MCF7; HT_HG-U133A

WDR19 FYN SHFL GEM

3.08e-041724342330_UP
DrugTrichostatin A, from Streptomyces sp.; Up 200; 0.1uM; MCF7; HT_HG-U133A

WDR19 FYN SHFL GEM

3.08e-041724343979_UP
DrugSAHA; Up 200; 10uM; MCF7; HT_HG-U133A

WDR19 FYN SHFL GEM

3.08e-041724345580_UP
Druglorcainide

SCN4A SCN9A

3.13e-0414432CID000042883
Drugoctylguanidine

SCN4A SCN9A

3.13e-0414432CID000030621
DrugTrichostatin A, from Streptomyces sp.; Up 200; 0.1uM; MCF7; HT_HG-U133A

WDR19 FYN SHFL GEM

3.15e-041734345625_UP
DrugTrichostatin A, from Streptomyces sp.; Up 200; 0.1uM; MCF7; HT_HG-U133A

WDR19 FYN SHFL GEM

3.22e-041744345260_UP
DrugTrichostatin A, Streptomyces sp.; Up 200; 0.1uM; MCF7; HT_HG-U133A

WDR19 FYN SHFL GEM

3.22e-041744345572_UP
DrugTrichostatin A, from Streptomyces sp.; Up 200; 0.1uM; MCF7; HT_HG-U133A

WDR19 FYN SHFL GEM

3.29e-041754342835_UP
DrugTrichostatin A, from Streptomyces sp.; Up 200; 0.1uM; MCF7; HT_HG-U133A

WDR19 FYN SHFL GEM

3.29e-041754343243_UP
DrugTrichostatin A, from Streptomyces sp.; Up 200; 0.1uM; MCF7; HT_HG-U133A

WDR19 FYN FOLR1 GEM

3.29e-041754343428_UP
DrugTrichostatin A, from Streptomyces sp.; Up 200; 0.1uM; MCF7; HT_HG-U133A

WDR19 FYN SHFL GEM

3.29e-041754345417_UP
DrugTrichostatin A, Streptomyces sp.; Up 200; 0.1uM; MCF7; HT_HG-U133A_EA

WDR19 FYN FOLR1 GEM

3.37e-04176434992_UP
DrugTrichostatin A, from Streptomyces sp.; Up 200; 0.1uM; MCF7; HT_HG-U133A

WDR19 FYN SHFL GEM

3.44e-041774344710_UP
DrugTrichostatin A, from Streptomyces sp.; Up 200; 0.1uM; MCF7; HT_HG-U133A

WDR19 FYN SHFL GEM

3.44e-041774346784_UP
DrugTrichostatin A, Streptomyces sp.; Up 200; 1uM; MCF7; HT_HG-U133A_EA

WDR19 RNF31 FYN GEM

3.44e-041774341072_UP
DrugTrichostatin A, from Streptomyces sp.; Up 200; 0.1uM; MCF7; HT_HG-U133A

WDR19 FYN FOLR1 GEM

3.44e-041774343395_UP
Drugtrichostatin A, Streptomyces sp.; Up 200; 1uM; MCF7; HT_HG-U133A

WDR19 FYN SHFL GEM

3.44e-041774345945_UP
DrugSAHA; Up 200; 10uM; MCF7; HT_HG-U133A

WDR19 FYN SHFL GEM

3.44e-041774341645_UP
DrugTrichostatin A, from Streptomyces sp.; Up 200; 0.1uM; MCF7; HT_HG-U133A

WDR19 FYN SHFL GEM

3.44e-041774344768_UP
DrugTrichostatin A, from Streptomyces sp.; Up 200; 0.1uM; MCF7; HT_HG-U133A

WDR19 FYN SHFL GEM

3.51e-041784345693_UP
Drugtrichostatin A ; Up 200; 1uM; MCF7; HT_HG-U133A_EA

WDR19 FYN SHFL GEM

3.51e-04178434873_UP
Drug2,3-dihydroxybenzaldehyde

LRP2 NF1 TG

3.56e-0473433CID000090579
Drugtrimethyloxonium

SCN4A SCN9A

3.60e-0415432CID000093245
Drugnonanol

SCN2A SCN4A

3.60e-0415432CID000008914
DrugAC1L1W4O

SCN4A SCN9A

3.60e-0415432CID000036625
DrugTrichostatin A, from Streptomyces sp.; Up 200; 0.1uM; MCF7; HT_HG-U133A

WDR19 FYN FOLR1 GEM

3.66e-041804347236_UP
DrugTrichostatin A, from Streptomyces sp.; Up 200; 0.1uM; MCF7; HT_HG-U133A

WDR19 FYN SHFL GEM

3.66e-041804342639_UP
DrugTrichostatin A, from Streptomyces sp.; Up 200; 0.1uM; MCF7; HT_HG-U133A

WDR19 FYN FOLR1 GEM

3.74e-041814347453_UP
DrugTrichostatin A, from Streptomyces sp.; Up 200; 0.1uM; MCF7; HT_HG-U133A

WDR19 FYN SHFL GEM

3.74e-041814341535_UP
DrugTrichostatin A, from Streptomyces sp.; Up 200; 0.1uM; MCF7; HT_HG-U133A

WDR19 FYN SHFL GEM

3.82e-041824343227_UP
Drugtrichostatin A, Streptomyces sp.; Up 200; 1uM; MCF7; HT_HG-U133A

WDR19 FYN SHFL GEM

3.82e-041824346879_UP
DrugTrichostatin A, from Streptomyces sp.; Up 200; 0.1uM; MCF7; HT_HG-U133A

WDR19 FYN SHFL GEM

3.82e-041824345017_UP
DrugLY 294002; Up 200; 10uM; MCF7; HT_HG-U133A_EA

WDR19 N4BP2L2 RNF31 FYN

3.90e-041834341074_UP
Drugscriptaid; Up 200; 10uM; MCF7; HT_HG-U133A

WDR19 FYN FOLR1 GEM

3.98e-041844346901_UP
Drugscriptaid; Up 200; 10uM; PC3; HT_HG-U133A

WDR19 FYN GEM DOP1A

3.98e-041844346919_UP
DrugTrichostatin A, Streptomyces sp.; Up 200; 0.1uM; MCF7; HT_HG-U133A

WDR19 FYN SHFL GEM

4.07e-041854341637_UP
Drugtrichostatin A, Streptomyces sp.; Up 200; 1uM; MCF7; HT_HG-U133A

WDR19 FYN SHFL GEM

4.07e-041854345935_UP
Drugtrichostatin A, Streptomyces sp.; Up 200; 1uM; MCF7; HT_HG-U133A

WDR19 FYN GEM TAX1BP1

4.07e-041854346916_UP
DrugTrichostatin A, from Streptomyces sp.; Up 200; 0.1uM; HL60; HG-U133A

WDR19 SLITRK5 SHFL ZNF652

4.15e-041864341612_UP
Drugtrichostatin A, Streptomyces sp.; Up 200; 1uM; MCF7; HT_HG-U133A

WDR19 FYN FOLR1 GEM

4.15e-041864346891_UP
DrugGBR 12909 dihydrochloride [67469-78-7]; Up 200; 7.6uM; MCF7; HT_HG-U133A

JMJD4 NF1 SHFL GEM

4.23e-041874343240_UP
Drugtrichostatin A, Streptomyces sp.; Up 200; 1uM; MCF7; HT_HG-U133A

WDR19 FYN SHFL GEM

4.23e-041874345976_UP
Drugwortmannin; Up 200; 0.01uM; MCF7; HT_HG-U133A_EA

WDR19 ZMYM2 FNDC3A ATRX

4.41e-04189434911_UP
Drug5253409; Up 200; 17uM; MCF7; HT_HG-U133A_EA

JMJD4 NF1 GEM WDR62

4.50e-04190434961_UP
DrugEconazole nitrate [24169-02-6]; Down 200; 9uM; PC3; HT_HG-U133A

PPP1R3D JMJD4 NF1 FYN

4.50e-041904347305_DN
DrugAlexidine dihydrochloride [22573-93-9]; Down 200; 6.8uM; PC3; HT_HG-U133A

PPP1R3D JMJD4 N4BP2L2 DOP1A

4.59e-041914347397_DN
DrugDiphenhydramine hydrochloride [147-24-0]; Down 200; 13.8uM; MCF7; HT_HG-U133A

ZMYM2 NF1 ATRX ZNF652

4.59e-041914346020_DN
Drug0179445-0000 [211246-22-9]; Down 200; 10uM; PC3; HT_HG-U133A

WDR19 JMJD4 ZNF236 ZNF652

4.59e-041914344289_DN
Drugarticaine

SCN4A SCN9A

4.65e-0417432CID000032169
Druglifarizine

SCN4A SCN9A

4.65e-0417432CID000071336
DrugAlprenolol hydrochloride [13707-88-5]; Down 200; 14uM; MCF7; HT_HG-U133A

FNDC3A NF1 ATRX FYN

4.68e-041924343188_DN
DrugRapamycin; Up 200; 0.1uM; MCF7; HT_HG-U133A_EA

WDR19 ZMYM2 N4BP2L2 RNF31

4.68e-041924341059_UP
Drugrosiglitazone; Up 200; 10uM; HL60; HT_HG-U133A

LRP2 FNDC3A MTMR12 SHFL

4.68e-041924341174_UP
Drug2-propylpentanoic acid; Up 200; 1000uM; MCF7; HT_HG-U133A

WDR19 N4BP2L2 FYN SHFL

4.68e-041924345206_UP
DrugFurosemide [54-31-9]; Down 200; 12uM; MCF7; HT_HG-U133A

FNDC3A NF1 ZDHHC3 SHFL

4.77e-041934343197_DN
DrugPridinol methanesulfonate salt [6856-31-1]; Down 200; 10.2uM; MCF7; HT_HG-U133A

TARDBP RNF31 FYN ZNF652

4.86e-041944347214_DN
DrugTetrahydroxy-1,4-quinone monohydrate [319-89-1]; Down 200; 21uM; MCF7; HT_HG-U133A

ZMYM2 MTMR12 NF1 FOLR1

4.86e-041944344159_DN
DrugRapamycin; Up 200; 0.1uM; MCF7; HT_HG-U133A_EA

WDR19 PPP1R3D ZMYM2 WDR62

4.86e-041944341001_UP
Drug0179445-0000 [211246-22-9]; Down 200; 1uM; MCF7; HT_HG-U133A

JMJD4 FNDC3A NF1 ATRX

4.86e-041944344758_DN
DrugPropantheline bromide [50-34-0]; Up 200; 9uM; MCF7; HT_HG-U133A

NF1 GEM ZNF652 WDR62

4.86e-041944344798_UP
Diseasegeneralized epilepsy with febrile seizures plus 2 (implicated_via_orthology)

SCN2A SCN4A SCN8A SCN9A

6.69e-1010414DOID:0111294 (implicated_via_orthology)
DiseaseDravet syndrome (implicated_via_orthology)

SCN2A SCN4A SCN8A SCN9A

6.69e-1010414DOID:0080422 (implicated_via_orthology)
Diseasegeneralized epilepsy with febrile seizures plus (implicated_via_orthology)

SCN2A SCN4A SCN8A SCN9A

1.57e-0912414DOID:0060170 (implicated_via_orthology)
DiseaseMental Retardation, Psychosocial

ZMYM2 NF1 FOLR1 WDR62 SCN8A

1.41e-06139415C0025363
DiseaseProfound Mental Retardation

ZMYM2 NF1 FOLR1 WDR62 SCN8A

1.41e-06139415C0020796
DiseaseMental deficiency

ZMYM2 NF1 FOLR1 WDR62 SCN8A

1.41e-06139415C0917816
Diseasesyndrome (implicated_via_orthology)

ZDHHC2 ZDHHC20 ZDHHC15

2.00e-0618413DOID:225 (implicated_via_orthology)
DiseaseB Virus Infection

SCN8A SCN9A

5.65e-063412C0037140
DiseaseBenign familial infantile epilepsy

SCN2A SCN8A

5.65e-063412cv:C5575231
DiseasePostherpetic neuralgia

SCN8A SCN9A

5.65e-063412C0032768
DiseaseHerpesviridae Infections

SCN8A SCN9A

5.65e-063412C0019372
DiseaseEpilepsy

FOLR1 SCN2A SCN8A SCN9A

1.61e-05109414C0014544
DiseaseFamilial benign neonatal epilepsy

SCN2A SCN8A

2.82e-056412C0220669
DiseaseIntellectual Disability

LRP2 ZMYM2 NF1 FOLR1 WDR62 SCN8A

3.35e-05447416C3714756
DiseaseGeneralized Epilepsy with Febrile Seizures Plus

SCN2A SCN9A

6.74e-059412C3502809
Diseaseepilepsy (implicated_via_orthology)

SCN2A SCN4A SCN8A SCN9A

7.75e-05163414DOID:1826 (implicated_via_orthology)
Diseaseautoimmune thyroiditis (is_implicated_in)

LRP2 TG

1.23e-0412412DOID:7188 (is_implicated_in)
DiseaseInfantile Severe Myoclonic Epilepsy

SCN2A SCN9A

1.46e-0413412C0751122
DiseaseEpilepsy, Cryptogenic

FOLR1 SCN2A SCN8A

2.04e-0482413C0086237
DiseaseAwakening Epilepsy

FOLR1 SCN2A SCN8A

2.04e-0482413C0751111
DiseaseAura

FOLR1 SCN2A SCN8A

2.04e-0482413C0236018
Diseaseanxiety disorder (implicated_via_orthology)

SCN2A SCN9A

4.28e-0422412DOID:2030 (implicated_via_orthology)
DiseaseHereditary Paraganglioma-Pheochromocytoma Syndrome

KMT2D NF1

4.68e-0423412C1708353
Diseasemalignant astrocytoma (is_marker_for)

NF1 ATRX

4.68e-0423412DOID:3069 (is_marker_for)
Diseaselung small cell carcinoma (is_implicated_in)

KMT2D ATRX

6.96e-0428412DOID:5409 (is_implicated_in)
Diseasealcohol use disorder measurement, longitudinal alcohol consumption measurement

ZMYM2 SCN8A

1.22e-0337412EFO_0007645, EFO_0009458
DiseaseCraniofacial Abnormalities

LRP2 ATRX FOLR1

1.33e-03156413C0376634

Protein segments in the cluster

PeptideGeneStartEntry
CTHFLWPMCIGEVAH

ACOT7L

31

Q6ZUV0
RALHQHCACKMHPQW

DOP1A

1646

Q5JWR5
HCACKMHPQWIGLIT

DOP1A

1651

Q5JWR5
KGENEWLHDHCMQVG

GEM

136

P55040
EFLPCHIMDQHWKFC

ANKRD31

1851

Q8N7Z5
EWVMGGHCFLDRCNH

MTMR12

426

Q9C0I1
CRHHLCEPDMKLVWP

MMS19

356

Q96T76
WDHCGKMEPTCKRHF

FOLR3

86

P41439
HGECIPAHWRCDKRN

LRP2

1076

P98164
KPHQVDGVQFMWDCC

ATRX

1561

P46100
HICEITWECLQPMKG

FNDC3A

1061

Q9Y2H6
CPISLHELMIHCWKK

FYN

491

P06241
MGCPHALHQLMLDCW

EPHA8

861

P29322
MPDWHHHCQVIMRSC

JMJD4

361

Q9H9V9
MQKARHCGHCPEEWI

KLRC4

111

O43908
WNHCGEMAPACKRHF

FOLR1

86

P15328
VLVMFHAPWCGHCKK

PDIA5

296

Q14554
FEEHVESHWKVCPMC

TAX1BP1

746

Q86VP1
CKIALDCNLPRWHMH

SCN4A

731

P35499
HMIDGRWCDCKLPNS

TARDBP

166

Q13148
PCMHLFHQLCVDQWL

RNF165

311

Q6ZSG1
VCKINDDCTLPRWHM

SCN9A

896

Q15858
GRHMLKDDWTVCPHC

WDR19

1281

Q8NEZ3
HLPWHCAACAMLNEP

RNF31

301

Q96EP0
KMWGLAEFHCPKCRH

SHFL

146

Q9NUL5
DSCILKMDHHCPWVN

ZDHHC20

146

Q5W0Z9
KMDHHCPWVNNCVGF

ZDHHC20

151

Q5W0Z9
CKRCIRKMDHHCPWV

ZDHHC3

146

Q9NYG2
RKMDHHCPWVNNCVG

ZDHHC3

151

Q9NYG2
HDNPWDCTCDIVGMK

SLITRK5

561

O94991
VCKISNDCELPRWHM

SCN2A

911

Q99250
PLEWHCKQMDHFVGL

NF1

2366

P21359
NHALHMPRGECEESW

PPP1R3D

281

O95685
CKINQDCELPRWHMH

SCN8A

906

Q9UQD0
RCVLKMDHHCPWLNN

ZDHHC16

176

Q969W1
HCVRRMDHHCPWINN

ZDHHC21

111

Q8IVQ6
MDHHCPWINNCVGED

ZDHHC21

116

Q8IVQ6
VQWRGEMKHFCDQHC

ZMYM2

781

Q9UBW7
IWHLGPEITNCMKQH

WDR62

741

O43379
MGLCGLLERCWLHHD

ZNF236

1

Q9UL36
RCIRKMDHHCPWVNN

ZDHHC7

151

Q9NXF8
MDHHCPWVNNCVGEK

ZDHHC7

156

Q9NXF8
CDKCILKMDHHCPWV

ZDHHC2

146

Q9UIJ5
LKMDHHCPWVNNCVG

ZDHHC2

151

Q9UIJ5
HCPWMENCVGERNHP

ZDHHC12

126

Q96GR4
IHIGHKQFMCQWCGK

ZNF652

406

Q9Y2D9
CWCVDAQGKEMHGTR

TG

336

P01266
CWQAEHCGEVHNKDM

USP6

491

P35125
HCGEVHNKDMSWPEE

USP6

496

P35125
CVLKMDHHCPWVNNC

ZDHHC15

151

Q96MV8
IQCRHCERWMHAGCE

KMT2D

1521

O14686
RCWKDHCMDKHNGTD

N4BP2L2

371

Q92802