Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	cysteine-type deubiquitinase activity	USP2 USP51 USP9X USP9Y	5.85e-04	114	67	4	GO:0004843
GeneOntologyMolecularFunction	co-SMAD binding	USP9X USP9Y	7.16e-04	12	67	2	GO:0070410
GeneOntologyMolecularFunction	deubiquitinase activity	USP2 USP51 USP9X USP9Y	8.03e-04	124	67	4	GO:0101005
GeneOntologyMolecularFunction	ribonucleoside triphosphate phosphatase activity	ABCA2 NLRP10 MDN1 SEPTIN3 RHOBTB1 ABCB9 DYNC2H1 ATL2 DNAH11	1.09e-03	775	67	9	GO:0017111
GeneOntologyMolecularFunction	ubiquitin-like protein peptidase activity	USP2 USP51 USP9X USP9Y	1.16e-03	137	67	4	GO:0019783
GeneOntologyMolecularFunction	diacylglycerol-dependent serine/threonine kinase activity	SMG1 PKN2	1.29e-03	16	67	2	GO:0004697
GeneOntologyMolecularFunction	minus-end-directed microtubule motor activity	DYNC2H1 DNAH11	1.64e-03	18	67	2	GO:0008569
GeneOntologyMolecularFunction	pyrophosphatase activity	ABCA2 NLRP10 MDN1 SEPTIN3 RHOBTB1 ABCB9 DYNC2H1 ATL2 DNAH11	1.88e-03	839	67	9	GO:0016462
GeneOntologyMolecularFunction	hydrolase activity, acting on acid anhydrides	ABCA2 NLRP10 MDN1 SEPTIN3 RHOBTB1 ABCB9 DYNC2H1 ATL2 DNAH11	1.90e-03	840	67	9	GO:0016817
GeneOntologyMolecularFunction	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	ABCA2 NLRP10 MDN1 SEPTIN3 RHOBTB1 ABCB9 DYNC2H1 ATL2 DNAH11	1.90e-03	840	67	9	GO:0016818
GeneOntologyBiologicalProcess	regulation of ARF protein signal transduction	IQSEC3 CYTH3 IQSEC2	5.29e-05	23	66	3	GO:0032012
GeneOntologyBiologicalProcess	ARF protein signal transduction	IQSEC3 CYTH3 IQSEC2	6.04e-05	24	66	3	GO:0032011
MousePheno	atrial septal defect	PDS5B MEGF8 DYNC2H1 PDS5A RYR1 DNAH11	5.89e-07	88	49	6	MP:0010403
MousePheno	abnormal interatrial septum morphology	PDS5B MEGF8 DYNC2H1 PDS5A RYR1 DNAH11	1.87e-06	107	49	6	MP:0000282
MousePheno	complete atrioventricular septal defect	PDS5B MEGF8 DYNC2H1 DNAH11	1.88e-06	26	49	4	MP:0010413
MousePheno	atrioventricular septal defect	PDS5B MEGF8 DYNC2H1 PDS5A DNAH11	1.08e-05	84	49	5	MP:0010412
MousePheno	abnormal Z line morphology	KALRN MTM1 RYR1 EPG5	1.11e-05	40	49	4	MP:0004091
MousePheno	abnormal atrioventricular septum morphology	PDS5B MEGF8 DYNC2H1 PDS5A DNAH11	1.28e-05	87	49	5	MP:0010592
MousePheno	abnormal I band morphology	KALRN MTM1 RYR1 EPG5	1.35e-05	42	49	4	MP:0030567
MousePheno	abnormal heart atrium morphology	PDS5B MEGF8 DYNC2H1 PDS5A CMYA5 RYR1 DNAH11	1.50e-05	232	49	7	MP:0003105
MousePheno	delayed bone ossification	PDS5B MEGF8 STAG1 PDS5A RYR1	7.92e-05	127	49	5	MP:0000060
MousePheno	abnormal heart looping	SMG1 MEGF8 DYNC2H1 USP9X PKN2	1.06e-04	135	49	5	MP:0000269
MousePheno	abnormal coronary artery morphology	MEGF8 DYNC2H1 RYR1	1.39e-04	29	49	3	MP:0004111
MousePheno	kyphosis	TOM1L2 STAG1 MTM1 PLA2G6 RYR1 EPG5	1.40e-04	229	49	6	MP:0000160
MousePheno	abnormal sarcomere morphology	KALRN MTM1 RYR1 EPG5	1.49e-04	77	49	4	MP:0004090
MousePheno	hindlimb paralysis	MTM1 PLA2G6 RYR1 EPG5	1.65e-04	79	49	4	MP:0000755
MousePheno	abnormal brown adipose tissue amount	PDS5B STAG1 PDS5A RYR1	1.91e-04	82	49	4	MP:0001778
MousePheno	limb paralysis	MTM1 PLA2G6 RYR1 EPG5	2.00e-04	83	49	4	MP:0013147
MousePheno	accessory spleen	MEGF8 DNAH11	4.27e-04	9	49	2	MP:0003342
MousePheno	double outlet right ventricle, ventricular defect committed to aorta	MEGF8 DNAH11	4.27e-04	9	49	2	MP:0011666
MousePheno	coronary fistula	MEGF8 DYNC2H1	4.27e-04	9	49	2	MP:0010476
MousePheno	abnormal respiratory function	PDS5B MTM1 PDS5A TNFAIP6 CUL7 RYR1 APBB1IP	4.47e-04	399	49	7	MP:0002327
MousePheno	decreased brown adipose tissue amount	PDS5B STAG1 PDS5A	4.85e-04	44	49	3	MP:0001780
MousePheno	respiratory distress	PDS5B MTM1 PDS5A CUL7 RYR1	7.13e-04	204	49	5	MP:0001954
MousePheno	fetal growth retardation	PDS5B PDS5A CUL7 RYR1	7.15e-04	116	49	4	MP:0004201
MousePheno	ostium secundum atrial septal defect	PDS5B RYR1	7.77e-04	12	49	2	MP:0010405
MousePheno	paralysis	MTM1 PLA2G6 RYR1 EPG5	7.87e-04	119	49	4	MP:0000753
MousePheno	abnormal spine curvature	TOM1L2 STAG1 MTM1 PLA2G6 RYR1 EPG5	8.11e-04	318	49	6	MP:0004174
MousePheno	d-loop transposition of the great arteries	MEGF8 DNAH11	9.16e-04	13	49	2	MP:0011665
MousePheno	right atrial isomerism	MEGF8 DNAH11	9.16e-04	13	49	2	MP:0006061
Domain	ARM-type_fold	PDS5B SMG1 STAG1 PIK3C2B USP9X PI4KA VEPH1 NOC3L PDS5A LRBA CUL7 USP9Y	1.23e-09	339	63	12	IPR016024
Domain	ARM-like	PDS5B SMG1 STAG1 USP9X NOC3L PDS5A LRBA CUL7 USP9Y	2.89e-07	270	63	9	IPR011989
Domain	ATPase_dyneun-rel_AAA	MDN1 DYNC2H1 DNAH11	1.30e-05	14	63	3	IPR011704
Domain	AAA_5	MDN1 DYNC2H1 DNAH11	1.30e-05	14	63	3	PF07728
Domain	-	IQSEC3 CYTH3 IQSEC2	1.62e-05	15	63	3	1.10.1000.11
Domain	Sec7	IQSEC3 CYTH3 IQSEC2	1.62e-05	15	63	3	PF01369
Domain	Sec7_alpha_orthog	IQSEC3 CYTH3 IQSEC2	1.62e-05	15	63	3	IPR023394
Domain	PI3/4_kinase_CS	SMG1 PIK3C2B PI4KA	1.62e-05	15	63	3	IPR018936
Domain	SPRY	TRIM64B TRIM4 TRIM64 CMYA5 RYR1	1.62e-05	94	63	5	PF00622
Domain	SPRY_dom	TRIM64B TRIM4 TRIM64 CMYA5 RYR1	1.62e-05	94	63	5	IPR003877
Domain	B30.2/SPRY	TRIM64B TRIM4 TRIM64 CMYA5 RYR1	1.70e-05	95	63	5	IPR001870
Domain	B302_SPRY	TRIM64B TRIM4 TRIM64 CMYA5 RYR1	1.70e-05	95	63	5	PS50188
Domain	Sec7	IQSEC3 CYTH3 IQSEC2	1.99e-05	16	63	3	SM00222
Domain	-	SMG1 PIK3C2B PI4KA	1.99e-05	16	63	3	1.10.1070.11
Domain	SEC7	IQSEC3 CYTH3 IQSEC2	1.99e-05	16	63	3	PS50190
Domain	Sec7_dom	IQSEC3 CYTH3 IQSEC2	1.99e-05	16	63	3	IPR000904
Domain	PI3Kc	SMG1 PIK3C2B PI4KA	1.99e-05	16	63	3	SM00146
Domain	PI3/4_kinase_cat_dom	SMG1 PIK3C2B PI4KA	2.88e-05	18	63	3	IPR000403
Domain	PI3_PI4_kinase	SMG1 PIK3C2B PI4KA	2.88e-05	18	63	3	PF00454
Domain	PI3_4_KINASE_3	SMG1 PIK3C2B PI4KA	2.88e-05	18	63	3	PS50290
Domain	PI3_4_KINASE_1	SMG1 PIK3C2B PI4KA	2.88e-05	18	63	3	PS00915
Domain	PI3_4_KINASE_2	SMG1 PIK3C2B PI4KA	2.88e-05	18	63	3	PS00916
Domain	IQSEC_PH	IQSEC3 IQSEC2	3.35e-05	3	63	2	IPR033742
Domain	IQ_SEC7_PH	IQSEC3 IQSEC2	3.35e-05	3	63	2	PF16453
Domain	USP_CS	USP2 USP51 USP9X USP9Y	7.24e-05	66	63	4	IPR018200
Domain	PH_dom-like	IQSEC3 KALRN CYTH3 MTM1 IQSEC2 VEPH1 LRBA APBB1IP	8.86e-05	426	63	8	IPR011993
Domain	USP_1	USP2 USP51 USP9X USP9Y	9.12e-05	70	63	4	PS00972
Domain	ConA-like_dom	TRIM64B TRIM4 TRIM64 LRBA CMYA5 RYR1	9.45e-05	219	63	6	IPR013320
Domain	UCH	USP2 USP51 USP9X USP9Y	9.64e-05	71	63	4	PF00443
Domain	USP_2	USP2 USP51 USP9X USP9Y	9.64e-05	71	63	4	PS00973
Domain	USP_3	USP2 USP51 USP9X USP9Y	1.02e-04	72	63	4	PS50235
Domain	USP_dom	USP2 USP51 USP9X USP9Y	1.02e-04	72	63	4	IPR028889
Domain	Peptidase_C19_UCH	USP2 USP51 USP9X USP9Y	1.02e-04	72	63	4	IPR001394
Domain	AAA+_ATPase	ABCA2 MDN1 ABCB9 DYNC2H1 DNAH11	1.25e-04	144	63	5	IPR003593
Domain	AAA	ABCA2 MDN1 ABCB9 DYNC2H1 DNAH11	1.25e-04	144	63	5	SM00382
Domain	SPRY	TRIM64B TRIM4 TRIM64 RYR1	2.12e-04	87	63	4	SM00449
Domain	DHC_N1	DYNC2H1 DNAH11	3.09e-04	8	63	2	PF08385
Domain	Dynein_heavy_dom-1	DYNC2H1 DNAH11	3.09e-04	8	63	2	IPR013594
Domain	-	IQSEC3 KALRN CYTH3 MTM1 IQSEC2 VEPH1 APBB1IP	3.37e-04	391	63	7	2.30.29.30
Domain	PH	IQSEC3 KALRN CYTH3 IQSEC2 VEPH1 APBB1IP	3.44e-04	278	63	6	SM00233
Domain	PH_DOMAIN	IQSEC3 KALRN CYTH3 IQSEC2 VEPH1 APBB1IP	3.50e-04	279	63	6	PS50003
Domain	PH_domain	IQSEC3 KALRN CYTH3 IQSEC2 VEPH1 APBB1IP	3.57e-04	280	63	6	IPR001849
Domain	PI3Ka	PIK3C2B PI4KA	3.97e-04	9	63	2	PF00613
Domain	-	PIK3C2B PI4KA	3.97e-04	9	63	2	1.25.40.70
Domain	PI3Ka	PIK3C2B PI4KA	3.97e-04	9	63	2	SM00145
Domain	PIK_HELICAL	PIK3C2B PI4KA	4.95e-04	10	63	2	PS51545
Domain	PI_Kinase	PIK3C2B PI4KA	4.95e-04	10	63	2	IPR015433
Domain	PInositide-3_kin_accessory_dom	PIK3C2B PI4KA	4.95e-04	10	63	2	IPR001263
Domain	-	ABCA2 NLRP10 MDN1 SEPTIN3 RHOBTB1 ABCB9 DYNC2H1 ATL2 DNAH11	8.45e-04	746	63	9	3.40.50.300
Domain	-	PDS5B USP9X PDS5A LRBA CUL7	9.10e-04	222	63	5	1.25.10.10
Domain	Dynein_heavy_chain_D4_dom	DYNC2H1 DNAH11	9.93e-04	14	63	2	IPR024317
Domain	Dynein_HC_stalk	DYNC2H1 DNAH11	9.93e-04	14	63	2	IPR024743
Domain	Dynein_heavy_dom-2	DYNC2H1 DNAH11	9.93e-04	14	63	2	IPR013602
Domain	DHC_N2	DYNC2H1 DNAH11	9.93e-04	14	63	2	PF08393
Domain	MT	DYNC2H1 DNAH11	9.93e-04	14	63	2	PF12777
Domain	AAA_8	DYNC2H1 DNAH11	9.93e-04	14	63	2	PF12780
Domain	DHC_fam	DYNC2H1 DNAH11	1.14e-03	15	63	2	IPR026983
Domain	Dynein_heavy_dom	DYNC2H1 DNAH11	1.14e-03	15	63	2	IPR004273
Domain	Dynein_heavy	DYNC2H1 DNAH11	1.14e-03	15	63	2	PF03028
Domain	BBOX	TRIM64B TRIM4 TRIM64	1.64e-03	69	63	3	SM00336
Domain	Butyrophylin	TRIM64B TRIM4 TRIM64	1.70e-03	70	63	3	IPR003879
Domain	HEAT_REPEAT	PDS5B SMG1 PDS5A	1.70e-03	70	63	3	PS50077
Domain	IQ	IQSEC3 IQSEC2 PPEF2	1.78e-03	71	63	3	PF00612
Domain	-	TRIM64B TRIM4 TRIM64	1.78e-03	71	63	3	4.10.45.10
Domain	zf-B_box	TRIM64B TRIM4 TRIM64	1.85e-03	72	63	3	PF00643
Domain	P-loop_NTPase	ABCA2 NLRP10 MDN1 SEPTIN3 RHOBTB1 ABCB9 DYNC2H1 ATL2 DNAH11	2.06e-03	848	63	9	IPR027417
Domain	ZF_BBOX	TRIM64B TRIM4 TRIM64	2.50e-03	80	63	3	PS50119
Domain	Znf_B-box	TRIM64B TRIM4 TRIM64	2.59e-03	81	63	3	IPR000315
Domain	IQ_motif_EF-hand-BS	IQSEC3 IQSEC2 PPEF2	3.49e-03	90	63	3	IPR000048
Domain	IQ	IQSEC3 IQSEC2 PPEF2	3.82e-03	93	63	3	PS50096
Pathway	KEGG_MEDICUS_REFERENCE_ESTABLISHMENT_OF_COHESION	PDS5B STAG1 PDS5A	7.93e-07	7	41	3	M47869
Pathway	REACTOME_COHESIN_LOADING_ONTO_CHROMATIN	PDS5B STAG1 PDS5A	2.70e-06	10	41	3	M27178
Pathway	REACTOME_COHESIN_LOADING_ONTO_CHROMATIN	PDS5B STAG1 PDS5A	2.70e-06	10	41	3	MM14892
Pathway	REACTOME_ESTABLISHMENT_OF_SISTER_CHROMATID_COHESION	PDS5B STAG1 PDS5A	3.71e-06	11	41	3	M27177
Pathway	REACTOME_ESTABLISHMENT_OF_SISTER_CHROMATID_COHESION	PDS5B STAG1 PDS5A	3.71e-06	11	41	3	MM14891
Pathway	REACTOME_MITOTIC_TELOPHASE_CYTOKINESIS	PDS5B STAG1 PDS5A	6.40e-06	13	41	3	M27661
Pathway	REACTOME_MITOTIC_TELOPHASE_CYTOKINESIS	PDS5B STAG1 PDS5A	6.40e-06	13	41	3	MM15363
Pathway	WP_PHOSPHATIDYL_INOSITOL_PHOSPHATE_PATHWAY	PIK3C2B PI4KA MTM1	3.18e-04	46	41	3	M48317
Pathway	REACTOME_RESOLUTION_OF_SISTER_CHROMATID_COHESION	PDS5B NUP85 STAG1 PDS5A	4.92e-04	127	41	4	M27181
Pathway	REACTOME_RESOLUTION_OF_SISTER_CHROMATID_COHESION	PDS5B NUP85 STAG1 PDS5A	5.21e-04	129	41	4	MM14894
Pathway	WP_10Q22Q23_COPY_NUMBER_VARIATION	PDS5B STAG1 PDS5A	8.41e-04	64	41	3	M48102
Pubmed	Functional contribution of Pds5 to cohesin-mediated cohesion in human cells and Xenopus egg extracts.	PDS5B STAG1 PDS5A	2.38e-07	7	67	3	15855230
Pubmed	Distinct roles of cohesin-SA1 and cohesin-SA2 in 3D chromosome organization.	PDS5B STAG1 PDS5A	3.80e-07	8	67	3	29867216
Pubmed	Sororin is required for stable binding of cohesin to chromatin and for sister chromatid cohesion in interphase.	PDS5B STAG1 PDS5A	5.69e-07	9	67	3	17349791
Pubmed	Human Scc4 is required for cohesin binding to chromatin, sister-chromatid cohesion, and mitotic progression.	PDS5B STAG1 PDS5A	5.69e-07	9	67	3	16682347
Pubmed	Human Wapl is a cohesin-binding protein that promotes sister-chromatid resolution in mitotic prophase.	PDS5B STAG1 PDS5A	5.69e-07	9	67	3	17112726
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	USP2 ABCA2 SEPTIN3 STAG1 KALRN USP9X CYTH3 MTM1 IQSEC2 CERCAM LRBA CMYA5 USP9Y	8.92e-07	1285	67	13	35914814
Pubmed	Wapl controls the dynamic association of cohesin with chromatin.	PDS5B STAG1 PDS5A	1.12e-06	11	67	3	17113138
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	ABCA2 MAN2A2 MDN1 NUP85 MEGF8 KALRN PIK3C2B CYTH3 PI4KA PLA2G6 LRBA RYR1	1.19e-06	1105	67	12	35748872
Pubmed	Aurora B and Cdk1 mediate Wapl activation and release of acetylated cohesin from chromosomes by phosphorylating Sororin.	PDS5B STAG1 PDS5A	3.06e-06	15	67	3	23901111
Pubmed	Deubiquitinating enzymes: a new class of biological regulators.	USP2 USP9X USP9Y	3.06e-06	15	67	3	9827704
Pubmed	PDS5A and PDS5B in Cohesin Function and Human Disease.	PDS5B PDS5A	3.66e-06	2	67	2	34070827
Pubmed	PDS5A and PDS5B differentially affect gene expression without altering cohesin localization across the genome.	PDS5B PDS5A	3.66e-06	2	67	2	35986423
Pubmed	Chromosomal mapping of two members of the human dynein gene family to chromosome regions 7p15 and 11q13 near the deafness loci DFNA 5 and DFNA 11.	DYNC2H1 DNAH11	3.66e-06	2	67	2	9325061
Pubmed	PDS5 proteins are required for proper cohesin dynamics and participate in replication fork protection.	PDS5B PDS5A	3.66e-06	2	67	2	31757807
Pubmed	The Drosophila developmental gene fat facets has a human homologue in Xp11.4 which escapes X-inactivation and has related sequences on Yq11.2.	USP9X USP9Y	3.66e-06	2	67	2	8922996
Pubmed	Usp9y (ubiquitin-specific protease 9 gene on the Y) is associated with a functional promoter and encodes an intact open reading frame homologous to Usp9x that is under selective constraint.	USP9X USP9Y	3.66e-06	2	67	2	12925892
Pubmed	Ubiquitin-specific protease activity of USP9Y, a male infertility gene on the Y chromosome.	USP9X USP9Y	3.66e-06	2	67	2	12895410
Pubmed	TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.	SMG1 MDN1 ACAD11 MEGF8 DYNC2H1 USP9X NRROS RYR1 DNAH11	3.69e-06	638	67	9	31182584
Pubmed	A strategy for modulation of enzymes in the ubiquitin system.	USP2 USP9X USP9Y	4.56e-06	17	67	3	23287719
Pubmed	A crucial role for Arf6 in the response of commissural axons to Slit.	IQSEC3 CYTH3 IQSEC2	6.48e-06	19	67	3	30674481
Pubmed	Cellular, biochemical and molecular changes in muscles from patients with X-linked myotubular myopathy due to MTM1 mutations.	MTM1 RYR1	1.10e-05	3	67	2	28007904
Pubmed	Pds5 Regulates Sister-Chromatid Cohesion and Chromosome Bi-orientation through a Conserved Protein Interaction Module.	PDS5B PDS5A	1.10e-05	3	67	2	28343969
Pubmed	Pds5B is required for cohesion establishment and Aurora B accumulation at centromeres.	PDS5B PDS5A	1.10e-05	3	67	2	24141881
Pubmed	Inactivating the lipid kinase activity of PI3KC2β is sufficient to rescue myotubular myopathy in mice.	PIK3C2B MTM1	1.10e-05	3	67	2	36943412
Pubmed	Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling.	IQSEC3 KALRN USP9X PI4KA IQSEC2 PKN2	1.74e-05	281	67	6	28706196
Pubmed	Lack of myotubularin (MTM1) leads to muscle hypotrophy through unbalanced regulation of the autophagy and ubiquitin-proteasome pathways.	MTM1 RYR1	2.19e-05	4	67	2	23695157
Pubmed	PDS5 proteins regulate the length of axial elements and telomere integrity during male mouse meiosis.	PDS5B PDS5A	2.19e-05	4	67	2	32285610
Pubmed	Topologically associating domains and chromatin loops depend on cohesin and are regulated by CTCF, WAPL, and PDS5 proteins.	PDS5B PDS5A	2.19e-05	4	67	2	29217591
Pubmed	PIK3C2B inhibition improves function and prolongs survival in myotubular myopathy animal models.	PIK3C2B MTM1	2.19e-05	4	67	2	27548528
Pubmed	Centronuclear myopathies: genotype-phenotype correlation and frequency of defined genetic forms in an Italian cohort.	MTM1 RYR1	2.19e-05	4	67	2	25957634
Pubmed	Sororin, a substrate of the anaphase-promoting complex, is required for sister chromatid cohesion in vertebrates.	PDS5B PDS5A	5.46e-05	6	67	2	15837422
Pubmed	Dosage effects of cohesin regulatory factor PDS5 on mammalian development: implications for cohesinopathies.	PDS5B PDS5A	7.63e-05	7	67	2	19412548
Pubmed	Shotgun sequencing of the human transcriptome with ORF expressed sequence tags.	SMG1 USP51 KALRN CARMIL3 USP9X RYR1 DNAH11	9.33e-05	552	67	7	10737800
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	IQSEC3 MDN1 SEPTIN3 KALRN USP9X CYTH3 PI4KA IQSEC2 CYRIB	9.35e-05	963	67	9	28671696
Pubmed	A potential role for human cohesin in mitotic spindle aster assembly.	STAG1 PDS5A	1.02e-04	8	67	2	11590136
Pubmed	Bridging expressed sequence alignments through targeted cDNA sequencing.	USP51 CARMIL3	1.02e-04	8	67	2	15028280
Pubmed	Quantitative analysis of cohesin complex stoichiometry and SMC3 modification-dependent protein interactions.	PDS5B PDS5A	1.02e-04	8	67	2	21699228
Pubmed	Long-term potentiation modulates synaptic phosphorylation networks and reshapes the structure of the postsynaptic interactome.	IQSEC3 SEPTIN3 KALRN CYTH3 IQSEC2	1.26e-04	251	67	5	27507650
Pubmed	Loss of ER retention motif of AGR2 can impact mTORC signaling and promote cancer metastasis.	ABCA2 MDN1 TRIM4 DYNC2H1 LRBA CYRIB RYR1 EPG5	1.58e-04	807	67	8	30575818
Pubmed	Scc1 sumoylation by Mms21 promotes sister chromatid recombination through counteracting Wapl.	PDS5B PDS5A	1.63e-04	10	67	2	22751501
Pubmed	Phosphorylation-enabled binding of SGO1-PP2A to cohesin protects sororin and centromeric cohesion during mitosis.	PDS5B PDS5A	1.63e-04	10	67	2	23242214
Pubmed	Usp9X Is Required for Lymphocyte Activation and Homeostasis through Its Control of ZAP70 Ubiquitination and PKCβ Kinase Activity.	USP2 USP9X	1.63e-04	10	67	2	26936881
Pubmed	Sororin mediates sister chromatid cohesion by antagonizing Wapl.	PDS5B PDS5A	1.63e-04	10	67	2	21111234
Pubmed	AAV-mediated intramuscular delivery of myotubularin corrects the myotubular myopathy phenotype in targeted murine muscle and suggests a function in plasma membrane homeostasis.	MTM1 RYR1	1.63e-04	10	67	2	18434328
Pubmed	Characterisation of the coding sequence and fine mapping of the human DFFRY gene and comparative expression analysis and mapping to the Sxrb interval of the mouse Y chromosome of the Dffry gene.	USP9X USP9Y	1.63e-04	10	67	2	9384609
Pubmed	Lineage-specific biology revealed by a finished genome assembly of the mouse.	TRIM64B TRIM64 EPG5	1.67e-04	55	67	3	19468303
Pubmed	Systematic proteomics of endogenous human cohesin reveals an interaction with diverse splicing factors and RNA-binding proteins required for mitotic progression.	PDS5B MDN1 STAG1 CCDC175 PDS5A	1.83e-04	272	67	5	31010829
Pubmed	Ubiquitin ligase TRIM71 suppresses ovarian tumorigenesis by degrading mutant p53.	USP9X CUL7	1.99e-04	11	67	2	31570706
Pubmed	APRIN is a cell cycle specific BRCA2-interacting protein required for genome integrity and a predictor of outcome after chemotherapy in breast cancer.	PDS5B PDS5A	1.99e-04	11	67	2	22293751
Pubmed	A protein interaction landscape of breast cancer.	TOM1L2 MDN1 USP9X PI4KA NOC3L PDS5A CUL7	2.18e-04	634	67	7	34591612
Pubmed	USP13 interacts with cohesin and regulates its ubiquitination in human cells.	STAG1 PDS5A	2.38e-04	12	67	2	33334891
Pubmed	Loss of Usp9x disrupts cortical architecture, hippocampal development and TGFβ-mediated axonogenesis.	USP9X USP9Y	2.38e-04	12	67	2	23861879
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	PDS5B MDN1 USP9X NOC3L PDS5A CUL7 HERC5	2.61e-04	653	67	7	22586326
Pubmed	Alternative splice variants encoding unstable protein domains exist in the human brain.	ABCA2 ABCB9	2.81e-04	13	67	2	15491607
Pubmed	The mouse homeobox gene Noto regulates node morphogenesis, notochordal ciliogenesis, and left right patterning.	DYNC2H1 DNAH11	2.81e-04	13	67	2	17884984
Pubmed	Biological insights from 108 schizophrenia-associated genetic loci.	TOM1L2 MAN2A2 SEPTIN3 ABCB9 STAG1	3.02e-04	303	67	5	25056061
Pubmed	MED12 regulates a transcriptional network of calcium-handling genes in the heart.	SLC8A2 RYR1	3.28e-04	14	67	2	28724790
Pubmed	Characterization of vertebrate cohesin complexes and their regulation in prophase.	STAG1 PDS5A	3.28e-04	14	67	2	11076961
Pubmed	Identification of dynein heavy chain genes expressed in human and mouse testis: chromosomal localization of an axonemal dynein gene.	DYNC2H1 DNAH11	3.28e-04	14	67	2	9373155
Pubmed	Why do cellular proteins linked to K63-polyubiquitin chains not associate with proteasomes?	TOM1L2 MDN1 PDS5A TNFAIP6	3.32e-04	170	67	4	23314748
Pubmed	Functional screening of FxxLF-like peptide motifs identifies SMARCD1/BAF60a as an androgen receptor cofactor that modulates TMPRSS2 expression.	NLRP10 MDN1	3.78e-04	15	67	2	19762545
Pubmed	Trim43a, Trim43b, and Trim43c: Novel mouse genes expressed specifically in mouse preimplantation embryos.	TRIM64B TRIM64	3.78e-04	15	67	2	19703589
Pubmed	Evolutionary strata on the mouse X chromosome correspond to strata on the human X chromosome.	USP9X USP9Y	3.78e-04	15	67	2	14762062
Pubmed	Characterization of size-fractionated cDNA libraries generated by the in vitro recombination-assisted method.	ACAD11 DYNC2H1	3.78e-04	15	67	2	12056414
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	PDS5B MDN1 TRIM4 DYNC2H1 USP9X PI4KA NOC3L PDS5A CMYA5 ATL2	3.82e-04	1425	67	10	30948266
Pubmed	FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.	PDS5B MDN1 PIK3C2B USP9X LRBA USP9Y	3.95e-04	497	67	6	36774506
Pubmed	A unique role of cohesin-SA1 in gene regulation and development.	PCDHB18P STAG1	4.31e-04	16	67	2	22415368
Pubmed	Differential physiological roles for BIN1 isoforms in skeletal muscle development, function and regeneration.	MTM1 RYR1	4.31e-04	16	67	2	32994313
Pubmed	LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.	TOM1L2 PDS5B NUP85 DYNC2H1 USP9X PI4KA NOC3L PDS5A	4.47e-04	942	67	8	31073040
Pubmed	Differential regulation of node formation, nodal ciliogenesis and cilia positioning by Noto and Foxj1.	DYNC2H1 DNAH11	4.88e-04	17	67	2	22357932
Pubmed	Menin and Menin-Associated Proteins Coregulate Cancer Energy Metabolism.	PDS5B NUP85 STAG1 NOC3L PDS5A	5.17e-04	341	67	5	32971831
Pubmed	Sex differences in sex chromosome gene expression in mouse brain.	USP9X USP9Y	5.48e-04	18	67	2	12023983
Pubmed	Interactome of the Autoimmune Risk Protein ANKRD55.	MDN1 USP9X PI4KA LRBA	5.79e-04	197	67	4	31620119
Pubmed	Reduction of Nipbl impairs cohesin loading locally and affects transcription but not cohesion-dependent functions in a mouse model of Cornelia de Lange Syndrome.	PCDHB18P STAG1	6.12e-04	19	67	2	23920377
Pubmed	Identification of a genomic reservoir for new TRIM genes in primate genomes.	TRIM64B TRIM64	6.12e-04	19	67	2	22144910
Pubmed	HectD1 controls hematopoietic stem cell regeneration by coordinating ribosome assembly and protein synthesis.	ACAD11 USP9X CUL7	6.45e-04	87	67	3	33711283
Pubmed	Genomic association analysis identifies multiple loci influencing antihypertensive response to an angiotensin II receptor blocker.	IQSEC3 APBB1IP	6.79e-04	20	67	2	22566498
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	USP9X PI4KA MTM1 CCDC138 NOC3L FBXO33 CUL7 PPEF2	9.01e-04	1049	67	8	27880917
Pubmed	Comprehensive Interactome Mapping of the DNA Repair Scaffold SLX4 Using Proximity Labeling and Affinity Purification.	PDS5B MDN1 ACAD11 PDS5A	9.04e-04	222	67	4	37071664
Pubmed	Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.	PIK3C2B DYNC2H1 USP9X PI4KA CUL7 ZMYM6	9.49e-04	588	67	6	38580884
Pubmed	Global genetic analysis in mice unveils central role for cilia in congenital heart disease.	MEGF8 DYNC2H1 DNAH11	9.67e-04	100	67	3	25807483
Pubmed	Cilia gene mutations cause atrioventricular septal defects by multiple mechanisms.	DYNC2H1 DNAH11	1.07e-03	25	67	2	27340223
Pubmed	Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	SLC8A2 IQSEC3 ABCA2	1.08e-03	104	67	3	10470851
Pubmed	ZNF750 interacts with KLF4 and RCOR1, KDM1A, and CTBP1/2 chromatin regulators to repress epidermal progenitor genes and induce differentiation genes.	PPP1R21 LRBA	1.15e-03	26	67	2	25228645
Pubmed	Proteomic identification of common SCF ubiquitin ligase FBXO6-interacting glycoproteins in three kinds of cells.	MAN2A2 NUP85 MEGF8 CERCAM NRROS FBXO34	1.17e-03	613	67	6	22268729
Pubmed	Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.	MDN1 NUP85 STAG1 PI4KA PDS5A CUL7 HERC5	1.30e-03	857	67	7	25609649
Pubmed	Molecular genetics of adult ADHD: converging evidence from genome-wide association and extended pedigree linkage studies.	MAN2A2 KALRN	1.34e-03	28	67	2	18839057
Pubmed	Analysis of lipid pathway genes indicates association of sequence variation near SREBF1/TOM1L2/ATPAF2 with dementia risk.	TOM1L2 ABCA2	1.44e-03	29	67	2	20167577
Pubmed	The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation.	MDN1 NUP85 USP9X PDS5A PKN2 LRBA	1.44e-03	638	67	6	33239621
Pubmed	Inherited genetic variant predisposes to aggressive but not indolent prostate cancer.	KALRN RYR1	1.54e-03	30	67	2	20080650
Pubmed	14-3-3 cooperates with LKB1 to regulate the activity and localization of QSK and SIK.	USP2 USP9X	1.54e-03	30	67	2	16306228
Pubmed	Comparison of an expanded ataxia interactome with patient medical records reveals a relationship between macular degeneration and ataxia.	ABCA2 MEGF8 KALRN	1.56e-03	118	67	3	21078624
Pubmed	Global proteomics of Ubqln2-based murine models of ALS.	TOM1L2 TRIM4 RYR1 HERC5	1.64e-03	261	67	4	33277362
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	TOM1L2 SLC8A2 IQSEC3 KALRN USP9X PI4KA IQSEC2 CYRIB DNAH11	1.64e-03	1431	67	9	37142655
Pubmed	Charting the molecular network of the drug target Bcr-Abl.	KRT24 PIK3C2B USP9X USP9Y	1.76e-03	266	67	4	19380743
Pubmed	Defining the membrane proteome of NK cells.	PPP1R21 ABCA2 MDN1 NUP85 USP9X PI4KA LRBA ATL2	1.78e-03	1168	67	8	19946888
Interaction	C3orf18 interactions	PDS5B SMG1 MDN1 DYNC2H1 PI4KA PDS5A LRBA	8.68e-08	115	65	7	int:C3orf18
Interaction	NPTN interactions	PDS5B SMG1 MDN1 NUP85 STAG1 DYNC2H1 PI4KA PDS5A	3.03e-06	278	65	8	int:NPTN
Interaction	WFDC5 interactions	PDS5B STAG1 PDS5A	8.95e-06	13	65	3	int:WFDC5
Interaction	CD70 interactions	PDS5B MDN1 NUP85 PDS5A LRBA HERC5	1.58e-05	166	65	6	int:CD70
Interaction	GYPA interactions	PDS5B SMG1 DYNC2H1 PDS5A LRBA CYRIB	2.06e-05	174	65	6	int:GYPA
Interaction	DLGAP1 interactions	IQSEC3 SEPTIN3 KALRN USP9X CYTH3 IQSEC2	2.49e-05	180	65	6	int:DLGAP1
GeneFamily	Ubiquitin specific peptidases	USP2 USP51 USP9X USP9Y	8.46e-06	56	42	4	366
GeneFamily	Ring finger proteins\|Tripartite motif containing\|ARF GTPase family	TRIM64B TRIM4 TRIM64 CMYA5	6.87e-05	95	42	4	59
ToppCell	390C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_6\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	IQSEC3 MTM1 IQSEC2 VEPH1 RYR1	2.76e-06	146	67	5	1bf67a9416f52198931b912a31be4bab09fefd19
ToppCell	390C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_6\|CD8+_Cytotoxic_T-cell / Donor, Lineage, Cell class and subclass (all cells)	IQSEC3 MTM1 IQSEC2 VEPH1 RYR1	3.36e-06	152	67	5	b8aa62e3cf2b4c252db4bccfa75d881c4fa0a788
ToppCell	facs-Marrow-B-cells-18m-Hematologic-MPP_Fraction_B_+_C\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KALRN RTN4RL1 CERCAM PLA2G6 CUL7	7.66e-06	180	67	5	7368ab31c3273374ef260f0d710d4eea83cbc4a2
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-24m-Macroglial-oligodendrocyte\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ABCA2 RGSL1 CARMIL3 TNFAIP6 PPP1R27	8.75e-06	185	67	5	7406a9fdd5beb2777a9cad3268673977bb19f050
Disease	matrix metalloproteinase measurement	DYNC2H1 PLA2G6	3.56e-04	13	64	2	EFO_0004744
Disease	Autosomal Dominant Myotubular Myopathy	MTM1 RYR1	3.56e-04	13	64	2	C3661489
Disease	Centronuclear myopathy	MTM1 RYR1	3.56e-04	13	64	2	C0175709
Disease	Congenital Structural Myopathy	MTM1 RYR1	3.56e-04	13	64	2	C0752282
Disease	X-linked centronuclear myopathy	MTM1 RYR1	3.56e-04	13	64	2	C0410203
Disease	Myopathy, Centronuclear, 1	MTM1 RYR1	3.56e-04	13	64	2	C4551952
Disease	Myopathy, Centronuclear, Autosomal Dominant	MTM1 RYR1	4.14e-04	14	64	2	C1834558
Disease	Tubular Aggregate Myopathy	MTM1 RYR1	4.14e-04	14	64	2	C0410207
Disease	Autosomal Recessive Centronuclear Myopathy	MTM1 RYR1	4.77e-04	15	64	2	C3645536
Disease	Alzheimer disease, brain volume measurement	PDS5B PKN2	6.17e-04	17	64	2	EFO_0006930, MONDO_0004975
Disease	Congenital Fiber Type Disproportion	MTM1 RYR1	6.93e-04	18	64	2	C0546264
Disease	aspartate aminotransferase measurement, serum alanine aminotransferase measurement, low density lipoprotein triglyceride measurement, body fat percentage, high density lipoprotein cholesterol measurement, sex hormone-binding globulin measurement	PPP1R21 PDS5B STAG1 RTN4RL1 PLA2G6	1.17e-03	364	64	5	EFO_0004612, EFO_0004696, EFO_0004735, EFO_0004736, EFO_0007800, EFO_0009946
Disease	selenium measurement	DYNC2H1 CMYA5	1.81e-03	29	64	2	EFO_0006331
Disease	response to candesartan	IQSEC3 APBB1IP	2.07e-03	31	64	2	GO_1901556
Disease	Polydactyly	MEGF8 DYNC2H1 USP9X	2.12e-03	117	64	3	C0152427

Protein segments in the cluster

Peptide	Gene	Start	Entry
QVEFDELFLRAVLHV	EPG5	681	Q9HCE0
HDFLETRFKIQQLLE	FBXO34	556	Q9NWN3
PELQIERFFEDHENV	APBB1IP	226	Q7Z5R6
FQEHLLRFVIDSLNE	DNAH11	1131	Q96DT5
ENLIHGDFRLDNIVF	ACAD11	216	Q709F0
NDFVHRIQEELDRFL	R3HCC1	16	Q9Y3T6
DDIFVDLVNLSHLFL	RTN4RL1	166	Q86UN2
DILLVNDHLLNFVRE	PDS5B	381	Q9NTI5
LSEHVFDLIQELFAI	PDS5A	261	Q29RF7
QFFRAELLVKDINDH	PCDHB18P	61	Q96TA0
IHFRLRLLEEAQLQD	MDN1	216	Q9NU22
IQHQRFLFEEAELRK	NLRP10	421	Q86W26
GLHQREVFLFNDLLV	IQSEC2	991	Q5JU85
EDNREFNLLDFSHLE	CARMIL3	186	Q8ND23
ELERFVNLHSLALDF	FBXO33	301	Q7Z6M2
DNILLAAFEFDIHQV	NUP85	346	Q9BW27
DREVLQELIFFLHRL	CUL7	721	Q14999
DLAAQVQELLEFLHE	KALRN	856	O60229
DLDQVQLHLEEVRFF	VEPH1	671	Q14D04
LLFFRQDQAHIDLFV	MEGF8	2636	Q7Z7M0
EEELERHAQFLLVNF	PI4KA	961	P42356
IILHIDNARLAADDF	KRT24	216	Q2M2I5
EEFVHINRLALESEF	LRBA	2401	P50851
IEENERLHIQFFEAD	PPP1R21	116	Q6ZMI0
HQREVFLFNDLLVIL	IQSEC3	891	Q9UPP2
FEEFQELHNKLRLLF	PIK3C2B	1406	O00750
IFQVDELLHRLNFFV	HERC5	591	Q9UII4
RLALFDFLLQVHDRL	GASK1A	421	Q9UFP1
DNQNLDILLFHEVLE	DYNC2H1	2621	Q8NCM8
FLLEREQLLFRHENA	CCDC138	211	Q96M89
QEEDLLNNHIFLFTR	CCDC175	591	P0C221
ESEQLLFIIRHRFNE	CMYA5	4026	Q8N3K9
HNFELDEEALEQILL	ATL2	71	Q8NHH9
LQAFVELHEFADLNL	CYTH3	131	O43739
ELHEFADLNLVQALR	CYTH3	136	O43739
DALFDELTAREHLQL	ABCA2	2136	Q9BZC7
DFHLLNLRTLQAEED	MAN2A2	1051	P49641
QFAEILHFTLRFDEL	CYRIB	131	Q9NUQ9
EDERVNFIHLILEAL	CERCAM	281	Q5T4B2
EIRQDLLDFHQDLLA	RYR1	2026	P21817
ELETLDLSHNQLLFF	NRROS	251	Q86YC3
HIDINEFLEAFRLVE	PPEF2	711	O14830
QDQQRLIDDHFLFDK	CKMT2	216	P17540
AHLINVEFFDDLLVV	NOC3L	526	Q8WTT2
EPVNLREQHDALEFF	USP9X	1676	Q93008
LNTQHLEFFREFLKE	RGSL1	651	A5PLK6
LQFLHDAVQSRDDLL	NKPD1	316	Q17RQ9
DNHRQVLEEIFFLKR	SMG1	3011	Q96Q15
LFQLELEADALVNFH	PLA2G6	71	O60733
ADVLFILQDQEHIFA	RHOBTB1	266	O94844
LEQQFPNHLLFEEDR	SELENOV	286	P59797
VKFLRLEDFLDNQRH	PKN2	446	Q16513
EDIRHFNIFDSVLDL	ABCB9	36	Q9NP78
DVLFLDHIRQGDLEQ	PPP1R27	31	Q86WC6
RQQDAHEFLIAILDV	USP51	446	Q70EK9
QRIHLSFLDFDLEDD	TNFAIP6	171	P98066
FEFNEQFLIIILDHL	MTM1	456	Q13496
FLELNRILEALHEQD	RMND5B	156	Q96G75
EFALLRDFVIRTHLQ	SEPTIN3	296	Q9UH03
QDRDIALLDLINFFI	STAG1	111	Q8WVM7
HVQEVQERLNFLRFL	USP9Y	651	O00507
RLFELRHEIEIFLSQ	ZMYM6	1081	O95789
LHNFLVEEEDLFLQR	TRIM4	206	Q9C037
HLQALEREAEELFQQ	TRIM64	196	A6NGJ6
EELLHVNDDLNNVFL	TOM1L2	286	Q6ZVM7
QDAQEFLRFLLDGLH	USP2	356	O75604
HLQALEREAEELFQQ	TRIM64B	196	A6NI03
IFEEDEHFFVRLLNL	SLC8A2	471	Q9UPR5