Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	cytoskeleton-nuclear membrane anchor activity	SYNE1 SYNE2 SUN1	1.66e-07	5	52	3	GO:0140444
GeneOntologyMolecularFunction	protein-membrane adaptor activity	SYNE1 SYNE2 SUN1	2.19e-04	45	52	3	GO:0043495
GeneOntologyMolecularFunction	cytoskeletal protein binding	MYO7A SYNE1 INPPL1 SYNE2 CEP135 TAOK1 KIFC3 JAKMIP2 KIF24 TTLL7	4.67e-04	1099	52	10	GO:0008092
GeneOntologyMolecularFunction	tubulin binding	CEP135 TAOK1 KIFC3 JAKMIP2 KIF24 TTLL7	8.28e-04	428	52	6	GO:0015631
GeneOntologyMolecularFunction	lamin binding	SYNE1 SUN1	1.11e-03	19	52	2	GO:0005521
GeneOntologyBiologicalProcess	nuclear migration	SYNE1 SYNE2 SLIT1 SUN1	1.84e-06	34	54	4	GO:0007097
GeneOntologyBiologicalProcess	centrosome localization	SYNE1 SYNE2 SUN1 ASPM	2.07e-06	35	54	4	GO:0051642
GeneOntologyBiologicalProcess	microtubule organizing center localization	SYNE1 SYNE2 SUN1 ASPM	2.32e-06	36	54	4	GO:0061842
GeneOntologyBiologicalProcess	nucleus localization	SYNE1 SYNE2 SLIT1 SUN1	5.27e-06	44	54	4	GO:0051647
GeneOntologyBiologicalProcess	nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration	SYNE2 SUN1	2.01e-05	3	54	2	GO:0021817
GeneOntologyBiologicalProcess	nuclear matrix anchoring at nuclear membrane	SYNE1 SUN1	2.01e-05	3	54	2	GO:0090292
GeneOntologyBiologicalProcess	nuclear matrix organization	SYNE1 SUN1	4.02e-05	4	54	2	GO:0043578
GeneOntologyBiologicalProcess	modulation of microtubule cytoskeleton involved in cerebral cortex radial glia guided migration	SYNE2 SUN1	6.69e-05	5	54	2	GO:0021815
GeneOntologyBiologicalProcess	nuclear migration along microtubule	SYNE2 SUN1	6.69e-05	5	54	2	GO:0030473
GeneOntologyBiologicalProcess	cell motility involved in cerebral cortex radial glia guided migration	SYNE2 SUN1	1.40e-04	7	54	2	GO:0021814
GeneOntologyBiologicalProcess	regulation of cilium assembly	SYNE1 SYNE2 CEP135 KIF24	1.84e-04	108	54	4	GO:1902017
GeneOntologyBiologicalProcess	organelle localization	NOP9 VPS33B MYO7A SYNE1 SYNE2 SLIT1 SUN1 ASPM	4.55e-04	703	54	8	GO:0051640
GeneOntologyCellularComponent	microtubule organizing center attachment site	SYNE1 SYNE2 SUN1	2.65e-06	11	54	3	GO:0034992
GeneOntologyCellularComponent	meiotic nuclear membrane microtubule tethering complex	SYNE1 SYNE2 SUN1	2.65e-06	11	54	3	GO:0034993
GeneOntologyCellularComponent	nuclear membrane protein complex	SYNE1 SYNE2 SUN1	2.65e-06	11	54	3	GO:0106083
GeneOntologyCellularComponent	nuclear membrane microtubule tethering complex	SYNE1 SYNE2 SUN1	2.65e-06	11	54	3	GO:0106094
GeneOntologyCellularComponent	preribosome, small subunit precursor	NOP9 FTSJ3	6.73e-04	15	54	2	GO:0030688
GeneOntologyCellularComponent	voltage-gated sodium channel complex	SCN3A SCN4A	8.69e-04	17	54	2	GO:0001518
HumanPheno	Scapular winging	SYNE1 SPEG DSTYK SYNE2 SCN4A	2.35e-05	99	19	5	HP:0003691
HumanPheno	Abnormal scapula morphology	SYNE1 SPEG DSTYK INPPL1 SYNE2 SCN4A	3.42e-05	181	19	6	HP:0000782
HumanPheno	Centrally nucleated skeletal muscle fibers	SYNE1 SPEG SYNE2 SCN4A	5.91e-05	60	19	4	HP:0003687
HumanPheno	Waddling gait	SYNE1 SPEG DSTYK SYNE2 SCN4A	8.74e-05	130	19	5	HP:0002515
HumanPheno	Abnormality of the shoulder girdle musculature	SYNE1 SPEG DSTYK SYNE2 SCN4A	1.67e-04	149	19	5	HP:0001435
HumanPheno	Abnormal muscle fiber emerin	SYNE1 SYNE2	1.96e-04	6	19	2	HP:0030116
HumanPheno	Absent muscle fiber emerin	SYNE1 SYNE2	1.96e-04	6	19	2	HP:0030117
Domain	IQ	IQSEC3 MYO7A SCN3A SCN4A ASPM	1.56e-06	71	52	5	PF00612
Domain	IQ_motif_EF-hand-BS	IQSEC3 MYO7A SCN3A SCN4A ASPM	5.05e-06	90	52	5	IPR000048
Domain	IQ	IQSEC3 MYO7A SCN3A SCN4A ASPM	5.93e-06	93	52	5	PS50096
Domain	DGCR6	DGCR6 DGCR6L	7.60e-06	2	52	2	PF07324
Domain	Gonadal	DGCR6 DGCR6L	7.60e-06	2	52	2	IPR010849
Domain	KASH	SYNE1 SYNE2	4.55e-05	4	52	2	PF10541
Domain	KASH	SYNE1 SYNE2	4.55e-05	4	52	2	IPR012315
Domain	KASH	SYNE1 SYNE2	4.55e-05	4	52	2	PS51049
Domain	KASH	SYNE1 SYNE2	4.55e-05	4	52	2	SM01249
Domain	IQ	MYO7A SCN3A SCN4A ASPM	7.59e-05	81	52	4	SM00015
Domain	Na_channel_asu	SCN3A SCN4A	3.37e-04	10	52	2	IPR001696
Domain	Na_trans_assoc	SCN3A SCN4A	3.37e-04	10	52	2	IPR010526
Domain	HAT	CRNKL1 ZFC3H1	3.37e-04	10	52	2	IPR003107
Domain	HAT	CRNKL1 ZFC3H1	3.37e-04	10	52	2	SM00386
Domain	Na_trans_assoc	SCN3A SCN4A	3.37e-04	10	52	2	PF06512
Domain	CH	SYNE1 SYNE2 ASPM	7.87e-04	65	52	3	SM00033
Domain	CH	SYNE1 SYNE2 ASPM	9.77e-04	70	52	3	PF00307
Domain	-	SYNE1 SYNE2 ASPM	1.02e-03	71	52	3	1.10.418.10
Domain	CH	SYNE1 SYNE2 ASPM	1.10e-03	73	52	3	PS50021
Domain	CH-domain	SYNE1 SYNE2 ASPM	1.19e-03	75	52	3	IPR001715
Domain	Actinin_actin-bd_CS	SYNE1 SYNE2	1.85e-03	23	52	2	IPR001589
Domain	Spectrin	SYNE1 SYNE2	1.85e-03	23	52	2	PF00435
Domain	ACTININ_2	SYNE1 SYNE2	1.85e-03	23	52	2	PS00020
Domain	ACTININ_1	SYNE1 SYNE2	1.85e-03	23	52	2	PS00019
Domain	Cys-rich_flank_reg_C	TRIL SLIT1 SLITRK4	2.02e-03	90	52	3	IPR000483
Domain	LRRCT	TRIL SLIT1 SLITRK4	2.02e-03	90	52	3	SM00082
Domain	LRR	TRIL SLIT1 SLITRK4 NXF1	2.35e-03	201	52	4	PS51450
Domain	LRRNT	TRIL SLIT1 SLITRK4	2.57e-03	98	52	3	IPR000372
Domain	LRRNT	TRIL SLIT1 SLITRK4	2.57e-03	98	52	3	SM00013
Domain	hEGF	FAT4 SLIT1	2.74e-03	28	52	2	PF12661
Domain	Spectrin_repeat	SYNE1 SYNE2	2.94e-03	29	52	2	IPR002017
Domain	LRR_1	TRIL SLIT1 SLITRK4 NXF1	3.21e-03	219	52	4	PF00560
Domain	Spectrin/alpha-actinin	SYNE1 SYNE2	3.57e-03	32	52	2	IPR018159
Domain	LRRCT	TRIL SLIT1	3.57e-03	32	52	2	PF01463
Domain	SPEC	SYNE1 SYNE2	3.57e-03	32	52	2	SM00150
Domain	FERM_N	MYO7A FRMPD2	3.80e-03	33	52	2	PF09379
Domain	FERM_N	MYO7A FRMPD2	3.80e-03	33	52	2	IPR018979
Domain	LAM_G_DOMAIN	FAT4 SLIT1	5.01e-03	38	52	2	PS50025
Domain	Laminin_G_2	FAT4 SLIT1	5.54e-03	40	52	2	PF02210
Pubmed	The inner nuclear membrane protein Sun1 mediates the anchorage of Nesprin-2 to the nuclear envelope.	SYNE1 SYNE2 SUN1	3.54e-09	3	54	3	16079285
Pubmed	SUN1 interacts with nuclear lamin A and cytoplasmic nesprins to provide a physical connection between the nuclear lamina and the cytoskeleton.	SYNE1 SYNE2 SUN1	1.41e-08	4	54	3	16648470
Pubmed	LINC complexes mediate the positioning of cone photoreceptor nuclei in mouse retina.	SYNE1 SYNE2 SUN1	1.41e-08	4	54	3	23071752
Pubmed	Outer nuclear membrane protein Kuduk modulates the LINC complex and nuclear envelope architecture.	SYNE1 SYNE2 SUN1	1.41e-08	4	54	3	28716842
Pubmed	Nesprins, but not sun proteins, switch isoforms at the nuclear envelope during muscle development.	SYNE1 SYNE2 SUN1	1.41e-08	4	54	3	20108321
Pubmed	Structural requirements for the assembly of LINC complexes and their function in cellular mechanical stiffness.	SYNE1 SYNE2 SUN1	3.53e-08	5	54	3	18396275
Pubmed	LINC complexes form by binding of three KASH peptides to domain interfaces of trimeric SUN proteins.	SYNE1 SYNE2 SUN1	3.53e-08	5	54	3	22632968
Pubmed	Nesprin 1α2 is essential for mouse postnatal viability and nuclear positioning in skeletal muscle.	SYNE1 SYNE2 SUN1	4.21e-07	10	54	3	28533284
Pubmed	Nuclear membrane proteins with potential disease links found by subtractive proteomics.	SYNE1 SYNE2 SUN1	4.21e-07	10	54	3	12958361
Pubmed	A conserved KASH domain protein associates with telomeres, SUN1, and dynactin during mammalian meiosis.	SYNE1 SYNE2 SUN1	5.79e-07	11	54	3	22826121
Pubmed	KASH protein Syne-2/Nesprin-2 and SUN proteins SUN1/2 mediate nuclear migration during mammalian retinal development.	SYNE1 SYNE2 SUN1	1.00e-06	13	54	3	21177258
Pubmed	SUN1/2 and Syne/Nesprin-1/2 complexes connect centrosome to the nucleus during neurogenesis and neuronal migration in mice.	SYNE1 SYNE2 SUN1	1.27e-06	14	54	3	19874786
Pubmed	MKRN2 Physically Interacts with GLE1 to Regulate mRNA Export and Zebrafish Retinal Development.	TOM1L2 MYO7A SYNE2 SLIT1 SUN1 POLR2E PSMB5	1.35e-06	358	54	7	32460013
Pubmed	Multiple novel nesprin-1 and nesprin-2 variants act as versatile tissue-specific intracellular scaffolds.	SYNE1 SYNE2	2.37e-06	2	54	2	22768332
Pubmed	Biochemical characterisation of the proteins encoded by the DiGeorge critical region 6 (DGCR6) genes.	DGCR6 DGCR6L	2.37e-06	2	54	2	15821931
Pubmed	Nesprin-1 and -2 are involved in the pathogenesis of Emery Dreifuss muscular dystrophy and are critical for nuclear envelope integrity.	SYNE1 SYNE2	2.37e-06	2	54	2	17761684
Pubmed	Nesprin-1-alpha2 associates with kinesin at myotube outer nuclear membranes, but is restricted to neuromuscular junction nuclei in adult muscle.	SYNE1 SYNE2	2.37e-06	2	54	2	31578382
Pubmed	Nesprins: a novel family of spectrin-repeat-containing proteins that localize to the nuclear membrane in multiple tissues.	SYNE1 SYNE2	2.37e-06	2	54	2	11792814
Pubmed	Two functional copies of the DGCR6 gene are present on human chromosome 22q11 due to a duplication of an ancestral locus.	DGCR6 DGCR6L	2.37e-06	2	54	2	11157784
Pubmed	Nesprin-1 and nesprin-2 regulate endothelial cell shape and migration.	SYNE1 SYNE2	2.37e-06	2	54	2	24931616
Pubmed	Dysregulation of DGCR6 and DGCR6L: psychopathological outcomes in chromosome 22q11.2 deletion syndrome.	DGCR6 DGCR6L	2.37e-06	2	54	2	22832905
Pubmed	A mouse gene (Dgcr6) related to the Drosophila gonadal gene is expressed in early embryogenesis and is the homolog of a human gene deleted in DiGeorge syndrome.	DGCR6 DGCR6L	2.37e-06	2	54	2	9605865
Pubmed	Syne-1 and Syne-2 play crucial roles in myonuclear anchorage and motor neuron innervation.	SYNE1 SYNE2	2.37e-06	2	54	2	17267447
Pubmed	Nesprins: tissue-specific expression of epsilon and other short isoforms.	SYNE1 SYNE2	2.37e-06	2	54	2	24718612
Pubmed	Targeted ablation of nesprin 1 and nesprin 2 from murine myocardium results in cardiomyopathy, altered nuclear morphology and inhibition of the biomechanical gene response.	SYNE1 SYNE2	2.37e-06	2	54	2	24586179
Pubmed	Distinct functional domains in nesprin-1alpha and nesprin-2beta bind directly to emerin and both interactions are disrupted in X-linked Emery-Dreifuss muscular dystrophy.	SYNE1 SYNE2	7.09e-06	3	54	2	17462627
Pubmed	Dynamics and molecular interactions of linker of nucleoskeleton and cytoskeleton (LINC) complex proteins.	SYNE2 SUN1	7.09e-06	3	54	2	19843581
Pubmed	Syne-1, a dystrophin- and Klarsicht-related protein associated with synaptic nuclei at the neuromuscular junction.	SYNE1 SYNE2	7.09e-06	3	54	2	10878022
Pubmed	Structures of FHOD1-Nesprin1/2 complexes reveal alternate binding modes for the FH3 domain of formins.	SYNE1 SYNE2	7.09e-06	3	54	2	33472039
Pubmed	Nesprins anchor kinesin-1 motors to the nucleus to drive nuclear distribution in muscle cells.	SYNE1 SYNE2	7.09e-06	3	54	2	25516977
Pubmed	The nesprins are giant actin-binding proteins, orthologous to Drosophila melanogaster muscle protein MSP-300.	SYNE1 SYNE2	7.09e-06	3	54	2	12408964
Pubmed	Megabase deletions of gene deserts result in viable mice.	HTR7 TTLL7	1.42e-05	4	54	2	15496924
Pubmed	Mammalian sperm head formation involves different polarization of two novel LINC complexes.	SYNE1 SUN1	1.42e-05	4	54	2	20711465
Pubmed	The RNA-binding motif protein 15B (RBM15B/OTT3) acts as cofactor of the nuclear export receptor NXF1.	RBM15B NXF1	1.42e-05	4	54	2	19586903
Pubmed	Nesprin-2 interacts with meckelin and mediates ciliogenesis via remodelling of the actin cytoskeleton.	SYNE1 SYNE2	1.42e-05	4	54	2	19596800
Pubmed	Prelamin A causes aberrant myonuclear arrangement and results in muscle fiber weakness.	SYNE1 SUN1	1.42e-05	4	54	2	30282816
Pubmed	The SUN2-nesprin-2 LINC complex and KIF20A function in the Golgi dispersal.	SYNE2 SUN1	1.42e-05	4	54	2	33686165
Pubmed	Coupling of the nucleus and cytoplasm: role of the LINC complex.	SYNE2 SUN1	1.42e-05	4	54	2	16380439
Pubmed	Nesprin-1α-Dependent Microtubule Nucleation from the Nuclear Envelope via Akap450 Is Necessary for Nuclear Positioning in Muscle Cells.	SYNE1 SUN1	1.42e-05	4	54	2	28966089
Pubmed	Lem2 is essential for cardiac development by maintaining nuclear integrity.	SYNE1 SYNE2 SUN1	1.70e-05	32	54	3	37067297
Pubmed	Identification of Human Neuronal Protein Complexes Reveals Biochemical Activities and Convergent Mechanisms of Action in Autism Spectrum Disorders.	CRNKL1 SYNE2 CEP135 FTSJ3	1.89e-05	101	54	4	26949739
Pubmed	Integration of cytogenetic with recombinational and physical maps of mouse chromosome 16.	DGCR6 DGCR6L	2.36e-05	5	54	2	10395793
Pubmed	Mammalian SUN protein interaction networks at the inner nuclear membrane and their role in laminopathy disease processes.	SYNE2 SUN1	2.36e-05	5	54	2	19933576
Pubmed	A molecular mechanism for LINC complex branching by structurally diverse SUN-KASH 6:6 assemblies.	SYNE1 SUN1	2.36e-05	5	54	2	33393904
Pubmed	Structure/function characterization of micro-conotoxin KIIIA, an analgesic, nearly irreversible blocker of mammalian neuronal sodium channels.	SCN3A SCN4A	2.36e-05	5	54	2	17724025
Pubmed	Structural Analysis of Different LINC Complexes Reveals Distinct Binding Modes.	SYNE1 SYNE2	3.54e-05	6	54	2	33058875
Pubmed	TorsinA binds the KASH domain of nesprins and participates in linkage between nuclear envelope and cytoskeleton.	SYNE1 SYNE2	3.54e-05	6	54	2	18827015
Pubmed	Functional activity of serotoninergic and melatoninergic systems expressed in the skin.	HTR7 MTNR1B	3.54e-05	6	54	2	12767050
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	CRNKL1 TBC1D4 VPS33B POLR2E PSMB5 ASPM SMARCA2 NDUFB4 NXF1 FTSJ3	3.86e-05	1353	54	10	29467282
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	TRIL IQSEC3 SYNE1 SPEG SLIT1 DCAF5	3.98e-05	407	54	6	12693553
Pubmed	SUN1 and SUN2 play critical but partially redundant roles in anchoring nuclei in skeletal muscle cells in mice.	SYNE1 SUN1	4.94e-05	7	54	2	19509342
Pubmed	The antiobesity factor WDTC1 suppresses adipogenesis via the CRL4WDTC1 E3 ligase.	MYO7A DIS3L POLR2E PSMB5 SMARCA2 NXF1	7.19e-05	453	54	6	27113764
Pubmed	Expression pattern of neuronal and skeletal muscle voltage-gated Na+ channels in the developing mouse heart.	SCN3A SCN4A	8.46e-05	9	54	2	15746173
Pubmed	International Union of Pharmacology. XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channels.	SCN3A SCN4A	8.46e-05	9	54	2	16382098
Pubmed	Identification of differential protein interactors of lamin A and progerin.	SYNE2 SUN1 PSMB5	8.77e-05	55	54	3	21327095
Pubmed	Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers.	CRNKL1 TBC1D4 INPPL1 POLR2E PSMB5 SMARCA2 NIT1 NDUFB4 FTSJ3	1.18e-04	1247	54	9	27684187
Pubmed	Meta-analysis of genome-wide association data of bipolar disorder and major depressive disorder.	FAT4 SYNE1	1.29e-04	11	54	2	20351715
Pubmed	LncRNAs-directed PTEN enzymatic switch governs epithelial-mesenchymal transition.	MYO7A SYNE1 CHPF JAKMIP2	1.38e-04	168	54	4	30631154
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	CRNKL1 DGCR6 DIS3L SYNE1 TAOK1 KIFC3 ZFC3H1 CHPF DCAF5	1.48e-04	1285	54	9	35914814
Pubmed	Comparative mapping of the DiGeorge syndrome region in mouse shows inconsistent gene order and differential degree of gene conservation.	DGCR6 DGCR6L	1.55e-04	12	54	2	9383280
Pubmed	Excess LINC complexes impair brain morphogenesis in a mouse model of recessive TOR1A disease.	SYNE2 SUN1	1.55e-04	12	54	2	29868845
Pubmed	p63 Transcription Factor Regulates Nuclear Shape and Expression of Nuclear Envelope-Associated Genes in Epidermal Keratinocytes.	SYNE2 SUN1	1.55e-04	12	54	2	28595999
Pubmed	Interactions of the Antiviral Factor Interferon Gamma-Inducible Protein 16 (IFI16) Mediate Immune Signaling and Herpes Simplex Virus-1 Immunosuppression.	CRNKL1 SYNE1 SUN1 NXF1 FTSJ3	1.66e-04	332	54	5	25693804
Pubmed	The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.	NOP9 POLR2E ASPM RBM15B ZFC3H1 NXF1 FTSJ3	1.67e-04	759	54	7	35915203
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	CRNKL1 NOP9 SYNE1 SYNE2 SUN1 POLR2E NXF1 FTSJ3	1.72e-04	1024	54	8	24711643
Pubmed	Global mapping of herpesvirus-host protein complexes reveals a transcription strategy for late genes.	NOP9 POLR2E ASPM TAOK1 GOLPH3 CHPF	1.74e-04	533	54	6	25544563
Pubmed	Kelch Domain of Gigaxonin Interacts with Intermediate Filament Proteins Affected in Giant Axonal Neuropathy.	SYNE1 SYNE2 KIFC3 ZFC3H1	2.07e-04	187	54	4	26460568
Pubmed	The protein network surrounding the human telomere repeat binding factors TRF1, TRF2, and POT1.	SYNE1 SYNE2 PSMB5 RBM15B	2.53e-04	197	54	4	20811636
Pubmed	Primary Autosomal Recessive Microcephalies and Seckel Syndrome Spectrum Disorders – RETIRED CHAPTER, FOR HISTORICAL REFERENCE ONLY	CEP135 ASPM	2.80e-04	16	54	2	20301772
Pubmed	Systematic analysis of human protein complexes identifies chromosome segregation proteins.	CRNKL1 SYNE1 CEP135 ASPM SMARCA2 KIFC3 KIF24 NXF1	3.87e-04	1155	54	8	20360068
Pubmed	Cloning and comparative mapping of the DiGeorge syndrome critical region in the mouse.	DGCR6 DGCR6L	4.42e-04	20	54	2	9740669
Pubmed	Deficient adaptation to centrosome duplication defects in neural progenitors causes microcephaly and subcortical heterotopias.	CEP135 ASPM	4.42e-04	20	54	2	34237032
Pubmed	The X-Linked-Intellectual-Disability-Associated Ubiquitin Ligase Mid2 Interacts with Astrin and Regulates Astrin Levels to Promote Cell Division.	PSMB5 ASPM	5.36e-04	22	54	2	26748699
Pubmed	Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.	TBC1D4 ZFC3H1 JAKMIP2	5.93e-04	105	54	3	9628581
Pubmed	Comparative Application of BioID and TurboID for Protein-Proximity Biotinylation.	SUN1 SMARCA2 NIT1 NDUFB4 NXF1	7.14e-04	457	54	5	32344865
Pubmed	Spatial centrosome proteome of human neural cells uncovers disease-relevant heterogeneity.	CEP135 KIF24	8.10e-04	27	54	2	35709258
Pubmed	Normal cardiovascular development in mice deficient for 16 genes in 550 kb of the velocardiofacial/DiGeorge syndrome region.	DGCR6 DGCR6L	8.72e-04	28	54	2	10963672
Pubmed	HENA, heterogeneous network-based data set for Alzheimer's disease.	SYNE1 CEP135 ZFC3H1	8.74e-04	120	54	3	31413325
Pubmed	Comparative mapping of the human 22q11 chromosomal region and the orthologous region in mice reveals complex changes in gene organization.	DGCR6 DGCR6L	1.00e-03	30	54	2	9405660
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	DIS3L DSTYK CEP135 TAOK1 ZFC3H1	1.00e-03	493	54	5	15368895
Pubmed	FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.	CRNKL1 MYO7A SPEG SLITRK4 TAOK1	1.04e-03	497	54	5	36774506
Pubmed	HSF1 phosphorylation establishes an active chromatin state via the TRRAP-TIP60 complex and promotes tumorigenesis.	FAT4 SYNE1 SYNE2 POLR2E PSMB5 NXF1	1.09e-03	754	54	6	35906200
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	TBC1D4 VPS33B SYNE2 SUN1 POLR2E CEP135 FTSJ3	1.15e-03	1049	54	7	27880917
Pubmed	Comparative Host Interactomes of the SARS-CoV-2 Nonstructural Protein 3 and Human Coronavirus Homologs.	TOM1L2 NRM MYH16 CHPF	1.16e-03	296	54	4	34186245
Pubmed	Comparative sequence analysis of 634 kb of the mouse chromosome 16 region of conserved synteny with the human velocardiofacial syndrome region on chromosome 22q11.2.	DGCR6 DGCR6L	1.21e-03	33	54	2	10704284
Pubmed	A genome- and phenome-wide association study to identify genetic variants influencing platelet count and volume and their pleiotropic effects.	DSTYK TAOK1	1.29e-03	34	54	2	24026423
Pubmed	Large-scale analysis of ion channel gene expression in the mouse heart during perinatal development.	SCN3A SCN4A KCNK3	1.33e-03	139	54	3	16985003
Pubmed	Host E3 ligase HUWE1 attenuates the proapoptotic activity of the MERS-CoV accessory protein ORF3 by promoting its ubiquitin-dependent degradation.	TBC1D4 INPPL1 POLR2E PSMB5 NXF1	1.43e-03	534	54	5	35032548
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	CRNKL1 NOP9 VPS33B SYNE1 PSMB5 RBM15B NXF1 FTSJ3	1.51e-03	1425	54	8	30948266
Pubmed	Sequence-ready physical map of the mouse chromosome 16 region with conserved synteny to the human velocardiofacial syndrome region on 22q11.2.	DGCR6 DGCR6L	1.52e-03	37	54	2	10337614
Pubmed	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.	CRNKL1 NOP9 SYNE1 RBM15B NXF1 FTSJ3	1.53e-03	807	54	6	22681889
Cytoband	17q23.3	SCN4A FTSJ3	5.78e-04	30	54	2	17q23.3
Cytoband	15q26.1	WDR93 VPS33B	1.87e-03	54	54	2	15q26.1
GeneFamily	Spectrin repeat containing nuclear envelope family	SYNE1 SYNE2	1.59e-05	4	30	2	1252
GeneFamily	Sodium voltage-gated channel alpha subunits	SCN3A SCN4A	9.51e-05	9	30	2	1203
GeneFamily	Kinesins\|Pleckstrin homology domain containing	KIFC3 KIF24	2.63e-03	46	30	2	622
GeneFamily	Ankyrin repeat domain containing\|FERM domain containing	MYO7A FRMPD2	3.10e-03	50	30	2	1293
GeneFamily	Sterile alpha motif domain containing	INPPL1 KIF24	9.33e-03	88	30	2	760
ToppCell	Pericytes-IPF_04\|World / lung cells shred on cell class, cell subclass, sample id	TRIL SPEG SLIT1 SLITRK4	3.30e-05	150	54	4	dbc202bd6db4fb5c8b2abd1200e074a2a9e63a59
ToppCell	Fetal_29-31_weeks-Mesenchymal-vascular_smooth_muscle_cell-D062\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	SPEG ASPM KCNK3 TTLL7	4.56e-05	163	54	4	51dee6c21cbeca4e17d1cc386e203f0c403089e8
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c03-GZMK\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	HTR7 SYNE1 SYNE2 ASPM	5.01e-05	167	54	4	abc4ba308ca3be41b0da604f5d82579fd58dff7b
ToppCell	Tuft-tuft-1\|World / Class top	MYO7A DIS3L FAAP24 JAKMIP2	5.13e-05	168	54	4	8ddc2ec483ed2c6c0fb2ae521c6861ceb6d32e34
ToppCell	BAL-Control-cDC_6\|Control / Compartment, Disease Groups and Clusters	SLITRK4 ASPM GOLPH3 KIFC3	5.13e-05	168	54	4	65ec473cff748b334c0a66e33bc34a8465fe7631
ToppCell	COVID-19-Heart-VSMC\|Heart / Disease (COVID-19 only), tissue and cell type	SPEG SCN3A KCNK3 TTLL7	6.56e-05	179	54	4	a69ad6912b5c10bb9f9d800f724c792341e9bab1
ToppCell	droplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_D_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HTR7 SCN3A KCNK3 SMARCA2	6.70e-05	180	54	4	8bf6e8b6b45ce42f8c5f23e7cd1752ec8b3fa2d2
ToppCell	facs-Brain_Non-Myeloid-Striatum-24m-Mesenchymal-brain_pericyte\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYO7A SYNE2 SCN3A CCDC160	7.45e-05	185	54	4	38486b69c48dc5e1c4e1488208fa8954a973eccb
ToppCell	facs-Brain_Non-Myeloid-Striatum-24m-Mesenchymal-Pericyte\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYO7A SYNE2 SCN3A CCDC160	7.45e-05	185	54	4	3c28b5ceba3cfdb6f7e32d5b42e03b6a81a7a658
ToppCell	(5)_Pericytes\|World / Cell class and subclass of bone marrow stroma cells in homeostatis	IQSEC3 HTR7 KCNK3 CCDC160	7.61e-05	186	54	4	acbca8cc048d87faf859b3e77bdb38d0a3dad71c
ToppCell	(5)_Pericytes-(50)_Pericytes\|World / Cell class and subclass of bone marrow stroma cells in homeostatis	IQSEC3 HTR7 KCNK3 CCDC160	7.61e-05	186	54	4	67b59defdd1ed3608229cc5e2a3b480d92312afa
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	TBC1D4 SYNE1 SYNE2 CCDC160	8.26e-05	190	54	4	b855b8b7d3439023390ca44629c1a99f5d4c6801
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_1\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	TBC1D4 SYNE1 SYNE2 CCDC160	8.26e-05	190	54	4	a5db902ad112a0c0a0a7f1a2e38718bb3bd11412
ToppCell	systemic_lupus_erythematosus-flare-Lymphocytic_T-CytoT_GZMH+-male\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	SYNE1 SYNE2 KIFC3 JAKMIP2	8.60e-05	192	54	4	fdc741e1846cfd8ed741b160e3c611c310c5d36d
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Medullary_Thick_Ascending_Limb_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	TBC1D4 SYNE2 SLITRK4 KIFC3	8.60e-05	192	54	4	ee27d27e3d269764dbe8711d0b37ff9331a298a9
ToppCell	Mild_COVID-19\|World / Disease group,lineage and cell class （2021.01.30）	TBC1D4 TRIM31 TAOK1 DGCR6L	8.78e-05	193	54	4	325b0768827bf8701bfb7f686bb11fd8b1a41a5c
ToppCell	Fibroblasts-Pericytes\|Fibroblasts / lung cells shred on cell class, cell subclass, sample id	SPEG SYNE2 KCNK3 TTLL7	9.13e-05	195	54	4	c2ebc0b33bda9b35b9ef26d69e5d2c6acfdb6ff1
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_T\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	TBC1D4 HTR7 SYNE1 SYNE2	9.32e-05	196	54	4	e4c76e7ad68455e51fe93ce588bcec9383f8654b
ToppCell	367C-Fibroblasts-Fibroblast-K_(Pericytes)\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	SPEG SYNE2 KCNK3 TTLL7	9.32e-05	196	54	4	1d94cecd378a829dd8014fc086d7fca48c953a91
ToppCell	367C-Fibroblasts-Fibroblast-K_(Pericytes)-\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	SPEG SYNE2 KCNK3 TTLL7	9.32e-05	196	54	4	aacec48285bcb7ccf1b538187071885e3602cc49
ToppCell	severe-low-quality_cells\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	SYNE1 SYNE2 SMARCA2 ZFC3H1	9.50e-05	197	54	4	57ebd552f10d6278623b52a3d484d4b91ae1d028
ToppCell	Tracheal-NucSeq-Stromal-Myofibroblastic-Muscle_smooth_pulmonary\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	SYNE1 SPEG KCNK3 TTLL7	9.50e-05	197	54	4	ac4f53acb2f8a428b0f2fab3c30a34e095a1bed7
ToppCell	PBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c08-IL2RB\|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)	FAT4 SYNE1 SYNE2 JAKMIP2	9.50e-05	197	54	4	bc37b8919f98dc18c2200834405f06823d965d78
ToppCell	mild_COVID-19_(asymptomatic)-NK\|World / disease group, cell group and cell class (v2)	FAT4 SYNE1 SYNE2 JAKMIP2	9.69e-05	198	54	4	7a0aac52d785037455e068e1b25de4b2bf0fff79
ToppCell	Sepsis-ICU-SEP-Lymphocyte-T/NK-gd_T\|ICU-SEP / Disease, condition lineage and cell class	WDR93 SYNE1 SYNE2 JAKMIP2	9.69e-05	198	54	4	b40899f8f5f32420fb4574069dd7afd9e7e70d91
ToppCell	COVID-19-COVID-19_Mild-Lymphocyte-T/NK-NK_activated\|COVID-19_Mild / Disease, condition lineage and cell class	FAT4 SYNE1 SYNE2 JAKMIP2	1.01e-04	200	54	4	2281debd86e5d92e8fe0397aec9ef670800f7471
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-1m-Mesenchymal\|1m / Sample Type, Dataset, Time_group, and Cell type.	DGCR6 SMARCA2 CHPF NDUFB4	1.01e-04	200	54	4	12359a6cf2c24cd373d4db3cab4d8ee2fb4a508f
Drug	B202	DGCR6 DGCR6L	5.32e-06	2	53	2	CID006435965
Drug	AC1NE2UB	NRM SYNE1 SYNE2 SUN1	8.79e-06	56	53	4	CID004635684
Drug	N-(2-methyl-3-(4-(4-(4-(trifluoromethoxy)benzyloxy)piperidin-1-yl)-1,3,5-triazin-2-ylamino)phenyl)acetamide	SCN3A SCN4A	1.59e-05	3	53	2	ctd:C561228
Disease	Autosomal dominant Emery-Dreifuss muscular dystrophy	SYNE1 SYNE2	1.82e-05	4	52	2	cv:CN293514
Disease	arthrogryposis multiplex congenita (is_implicated_in)	VPS33B SYNE1	1.82e-05	4	52	2	DOID:0080954 (is_implicated_in)
Disease	Autosomal Recessive Emery-Dreifuss Muscular Dystrophy	SYNE1 SYNE2	3.04e-05	5	52	2	C1450051
Disease	proline measurement, amino acid measurement	DGCR6 DGCR6L	3.04e-05	5	52	2	EFO_0005134, EFO_0009773
Disease	Autosomal Dominant Emery-Dreifuss Muscular Dystrophy (disorder)	SYNE1 SYNE2	3.04e-05	5	52	2	C0410190
Disease	Emery-Dreifuss muscular dystrophy	SYNE1 SYNE2	4.55e-05	6	52	2	cv:C0410189
Disease	Muscular Dystrophy, Emery-Dreifuss	SYNE1 SYNE2	4.55e-05	6	52	2	C0410189
Disease	X-Linked Emery-Dreifuss Muscular Dystrophy	SYNE1 SYNE2	6.36e-05	7	52	2	C0751337
Disease	generalized epilepsy with febrile seizures plus 2 (implicated_via_orthology)	SCN3A SCN4A	1.36e-04	10	52	2	DOID:0111294 (implicated_via_orthology)
Disease	Dravet syndrome (implicated_via_orthology)	SCN3A SCN4A	1.36e-04	10	52	2	DOID:0080422 (implicated_via_orthology)
Disease	Emery-Dreifuss muscular dystrophy (implicated_via_orthology)	SYNE1 SYNE2	1.99e-04	12	52	2	DOID:11726 (implicated_via_orthology)
Disease	generalized epilepsy with febrile seizures plus (implicated_via_orthology)	SCN3A SCN4A	1.99e-04	12	52	2	DOID:0060170 (implicated_via_orthology)
Disease	Autosomal recessive primary microcephaly	CEP135 ASPM	3.15e-04	15	52	2	cv:C3711387
Disease	reticulocyte count	DGCR6 DSTYK SYNE2 PSMB5 KCNK3 TRIM31 USP48 DGCR6L	4.54e-04	1045	52	8	EFO_0007986
Disease	Primary microcephaly	CEP135 ASPM	6.88e-04	22	52	2	C0431350
Disease	Autosomal Recessive Primary Microcephaly	CEP135 ASPM	6.88e-04	22	52	2	C3711387
Disease	anxiety disorder (implicated_via_orthology)	HTR7 SCN3A	6.88e-04	22	52	2	DOID:2030 (implicated_via_orthology)
Disease	glycerol measurement	FAT4 SMARCA2	9.64e-04	26	52	2	EFO_0010115
Disease	proline measurement	DGCR6 DGCR6L	9.64e-04	26	52	2	EFO_0009773
Disease	glucose tolerance test	TBC1D4 MTNR1B	1.04e-03	27	52	2	EFO_0004307

Protein segments in the cluster

Peptide	Gene	Start	Entry
LEAKRQNLRRALDQY	C8A	476	P07357
QNEKREYLLRQSLRG	FAT4	4221	Q6V0I7
KSLYNQRLRLQNEHR	DGCR6	76	Q14129
NRAAKLQRQHYLRQR	ASPM	2371	Q8IZT6
LQRRLLRNLVSYLKQ	RBM15B	816	Q8NDT2
RRRVLQNLKGQYVAL	NOP9	541	Q86U38
LRFRQLTKEYQALQR	JAKMIP2	476	Q96AA8
LELRQQELRARYNLS	KCNK3	41	O14649
LRNRKLRNAGNLFLV	MTNR1B	66	P49286
LNQNFRREYKRILLA	MTNR1B	311	P49286
ELLSLNLSNNRLYRL	NXF1	266	Q9UBU9
QRLSALRRYQDKRLL	DCAF5	511	Q96JK2
QLYDLLNRRKRLFAR	KIF24	366	Q5T7B8
QQDLRYLRAQLQRKL	NRM	236	Q8IXM6
YLRAQLQRKLHLLSR	NRM	241	Q8IXM6
RKRLYRIGLNLFNIN	IQSEC3	651	Q9UPP2
RLAIRAQLKREYLLQ	NDUFB4	36	O95168
RYLGRLRQNLRETQK	DSTYK	36	Q6XUX3
NIRKRLDQLGYRQTL	CEP135	11	Q66GS9
RNLYRRLLQRTQHVK	CRNKL1	696	Q9BZJ0
VQQNRSYLLRKRLRG	FRMPD2	201	Q68DX3
GRRQYNKLRNLLKDA	DIS3L	96	Q8TF46
GYRKRLVRVRNSNNL	FAAP24	71	Q9BTP7
LQARNNRALELLRKY	CCDC160	291	A6NGH7
LHYQLRNVRERLAKN	GOLPH3	166	Q9H4A6
KSLYNQRLRLQNEHR	DGCR6L	76	Q9BY27
RDNSRNSLYLQKNRR	IGHV3-16	91	A0A0C4DH30
LCLARIDLNYLRQLR	NIT1	291	Q86X76
NLRRLYLNGNQIERL	SLITRK4	426	Q8IW52
RKNAIRFNSLLRNLV	TRIM31	61	Q9BZY9
ARYKLRENQLPRIQA	POLR2E	161	P19388
AIKIQRAYRRHLLQR	SCN4A	1731	P35499
KALRLLNFQRQLRQE	SMARCA2	381	P51531
LELINKQYRRLAREN	SYNE1	8056	Q8NF91
TQLELINKQYRRLAR	SYNE2	6191	Q8WXH0
SNNQELLRKYRRELQ	KIFC3	416	Q9BVG8
NRRFQFLQKARALLD	FTSJ3	36	Q8IY81
RRNQNYLDILRLLSL	INPPL1	571	O15357
ANLLRRQRQYLELEC	TAOK1	601	Q7L7X3
IIQRNFRCYLLKQRL	SCN3A	1906	Q9NY46
RSLLQCQYRNINRKL	HTR7	396	P34969
LRLQKQQLVNGYRRF	CHPF	441	Q8IZ52
GEYAQRLQALRQRLL	SPEG	2061	Q15772
RANKNCRILQYRLRK	SOGA3	401	Q5TF21
RLGQLRRLDLQYNQI	TRIL	81	Q7L0X0
LALQYRLRHRLPNKQ	TBC1D4	931	O60343
RKQYNLQERRLSLLQ	MYH16	831	Q9H6N6
RLQRYSLSLQRENFK	WDR93	671	Q6P2C0
RNQKCYFLLQILRRI	SUN1	216	O94901
RLLARQCRIYELRNK	PSMB5	116	P28074
IRALKKRLNGNRNYR	TOM1L2	51	Q6ZVM7
PYRKLRRIDLSNNQI	SLIT1	331	O75093
RCRILRLKNQLNEDY	USP48	561	Q86UV5
QREVHRLYQRALQKL	ZFC3H1	1921	O60293
LSQKARNLQAQYDRR	VPS33B	301	Q9H267
AQRRLYGQNSIKRLL	TTLL7	396	Q6ZT98
LQRLQKALRNGSRKY	MYO7A	1871	Q13402