Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	ubiquitin-protein transferase activity	UBR1 RNF166 RNF168 SH3RF1 IRF2BP1 MYCBP2 SH3RF2 TRIM55 TRIM54 BIRC3 FBXO30 RBCK1	1.87e-09	473	51	12	GO:0004842
GeneOntologyMolecularFunction	ubiquitin protein ligase activity	UBR1 RNF166 RNF168 SH3RF1 IRF2BP1 MYCBP2 SH3RF2 TRIM55 TRIM54 BIRC3 FBXO30	1.98e-09	372	51	11	GO:0061630
GeneOntologyMolecularFunction	ubiquitin-like protein ligase activity	UBR1 RNF166 RNF168 SH3RF1 IRF2BP1 MYCBP2 SH3RF2 TRIM55 TRIM54 BIRC3 FBXO30	4.00e-09	398	51	11	GO:0061659
GeneOntologyMolecularFunction	ubiquitin-like protein transferase activity	UBR1 RNF166 RNF168 SH3RF1 IRF2BP1 MYCBP2 SH3RF2 TRIM55 TRIM54 BIRC3 FBXO30 RBCK1	4.54e-09	512	51	12	GO:0019787
GeneOntologyMolecularFunction	aminoacyltransferase activity	UBR1 RNF166 RNF168 SH3RF1 IRF2BP1 MYCBP2 SH3RF2 TRIM55 TRIM54 BIRC3 FBXO30 RBCK1	6.97e-09	532	51	12	GO:0016755
GeneOntologyMolecularFunction	acyltransferase activity	UBR1 RNF166 RNF168 SH3RF1 IRF2BP1 MYCBP2 SH3RF2 TRIM55 TRIM54 BIRC3 CREBBP FBXO30 RBCK1	4.99e-08	775	51	13	GO:0016746
GeneOntologyMolecularFunction	zinc ion binding	UBR1 TRIM67 MYCBP2 TRPS1 TRIM55 NFXL1 TRIM54 ZNFX1 CREBBP FBXO30	7.19e-05	891	51	10	GO:0008270
GeneOntologyMolecularFunction	hormone binding	RXFP2 INSR MC1R LRP2	1.38e-04	103	51	4	GO:0042562
GeneOntologyMolecularFunction	DNA-binding transcription factor activity, RNA polymerase II-specific	GSX1 GCM2 TRPS1 ZFP57 NFXL1 ZNF229 RREB1 OLIG1 ZBTB1 ZBTB24 NOTCH2 NOTCH4	1.78e-04	1412	51	12	GO:0000981
GeneOntologyMolecularFunction	insulin-like growth factor I binding	INSR LRP2	4.90e-04	13	51	2	GO:0031994
GeneOntologyMolecularFunction	transition metal ion binding	UBR1 TRIM67 MYCBP2 TRPS1 TRIM55 NFXL1 TRIM54 ZNFX1 CREBBP FBXO30	7.35e-04	1189	51	10	GO:0046914
GeneOntologyMolecularFunction	RNA polymerase II transcription regulatory region sequence-specific DNA binding	GSX1 GCM2 TRPS1 ZFP57 NFXL1 ZNF229 RREB1 OLIG1 ZBTB1 CREBBP ZBTB24	9.56e-04	1459	51	11	GO:0000977
GeneOntologyMolecularFunction	insulin-like growth factor binding	INSR LRP2	1.06e-03	19	51	2	GO:0005520
GeneOntologyMolecularFunction	protein-hormone receptor activity	RXFP2 INSR	1.43e-03	22	51	2	GO:0016500
GeneOntologyMolecularFunction	K63-linked polyubiquitin modification-dependent protein binding	RNF168 ZBTB1	2.00e-03	26	51	2	GO:0070530
GeneOntologyMolecularFunction	monoatomic ion-gated channel activity	TMEM63B KCNT1	2.84e-03	31	51	2	GO:0022839
GeneOntologyMolecularFunction	DNA-binding transcription activator activity, RNA polymerase II-specific	GSX1 GCM2 ZNF229 RREB1 NOTCH2 NOTCH4	2.92e-03	560	51	6	GO:0001228
GeneOntologyMolecularFunction	DNA-binding transcription activator activity	GSX1 GCM2 ZNF229 RREB1 NOTCH2 NOTCH4	3.08e-03	566	51	6	GO:0001216
GeneOntologyBiologicalProcess	protein ubiquitination	UBR1 RNF166 RNF168 SH3RF1 IRF2BP1 MYCBP2 SH3RF2 TRIM55 TRIM54 BIRC3 FBXO30 RBCK1	4.86e-07	811	51	12	GO:0016567
GeneOntologyBiologicalProcess	protein modification by small protein conjugation	UBR1 RNF166 RNF168 SH3RF1 IRF2BP1 MYCBP2 SH3RF2 TRIM55 TRIM54 BIRC3 FBXO30 RBCK1	1.34e-06	893	51	12	GO:0032446
GeneOntologyBiologicalProcess	protein modification by small protein conjugation or removal	UBR1 RNF166 RNF168 SH3RF1 IRF2BP1 MYCBP2 SH3RF2 TRIM55 TRIM54 BIRC3 FBXO30 RBCK1	4.76e-06	1009	51	12	GO:0070647
GeneOntologyBiologicalProcess	protein polyubiquitination	RNF166 RNF168 IRF2BP1 MYCBP2 TRIM55 BIRC3 RBCK1	6.74e-06	289	51	7	GO:0000209
GeneOntologyBiologicalProcess	post-translational protein modification	UBR1 RNF166 RNF168 SH3RF1 IRF2BP1 MYCBP2 SH3RF2 TRIM55 TRIM54 BIRC3 FBXO30 RBCK1	8.99e-06	1074	51	12	GO:0043687
GeneOntologyBiologicalProcess	gland development	GSX1 MAN2A1 GCM2 INSR RREB1 ZBTB1 NOTCH2 NOTCH4	6.24e-05	558	51	8	GO:0048732
GeneOntologyBiologicalProcess	cellular response to UV	RNF168 MC1R ZBTB1 CREBBP	9.69e-05	97	51	4	GO:0034644
GeneOntologyBiologicalProcess	regulation of non-canonical NF-kappaB signal transduction	TRIM55 BIRC3 CREBBP RBCK1	2.20e-04	120	51	4	GO:1901222
GeneOntologyBiologicalProcess	positive regulation of intracellular signal transduction	SH3RF1 SH3RF2 RXFP2 INSR MC1R TRIM55 BIRC3 BMPER CREBBP NOTCH2 RBCK1	2.73e-04	1299	51	11	GO:1902533
GeneOntologyBiologicalProcess	cellular response to light stimulus	RNF168 MC1R ZBTB1 CREBBP	2.99e-04	130	51	4	GO:0071482
GeneOntologyBiologicalProcess	regulation of BMP signaling pathway	MTMR4 LRP2 BMPER NOTCH2	3.08e-04	131	51	4	GO:0030510
MousePheno	absent tracheal cartilage rings	TRPS1 BMPER	2.64e-05	3	42	2	MP:0004553
Domain	ZF_RING_1	UBR1 RNF166 TRIM67 RNF168 SH3RF1 MYCBP2 SH3RF2 TRIM55 NFXL1 TRIM54 BIRC3 RBCK1	1.51e-11	291	51	12	PS00518
Domain	ZF_RING_2	UBR1 RNF166 TRIM67 RNF168 SH3RF1 MYCBP2 SH3RF2 TRIM55 NFXL1 TRIM54 BIRC3 RBCK1	1.99e-11	298	51	12	PS50089
Domain	Znf_RING	UBR1 RNF166 TRIM67 RNF168 SH3RF1 MYCBP2 SH3RF2 TRIM55 NFXL1 TRIM54 BIRC3 RBCK1	5.64e-11	326	51	12	IPR001841
Domain	Znf_RING/FYVE/PHD	UBR1 MTMR4 RNF166 TRIM67 RNF168 SH3RF1 MYCBP2 SH3RF2 TRIM55 TRIM54 BIRC3 KDM4B RBCK1	2.05e-10	459	51	13	IPR013083
Domain	Znf_C3HC4_RING-type	RNF166 TRIM67 RNF168 SH3RF1 IRF2BP1 SH3RF2 TRIM55 TRIM54 RBCK1	8.43e-10	172	51	9	IPR018957
Domain	-	UBR1 MTMR4 RNF166 TRIM67 RNF168 SH3RF1 MYCBP2 SH3RF2 TRIM55 TRIM54 KDM4B RBCK1	2.19e-09	449	51	12	3.30.40.10
Domain	RING	RNF166 TRIM67 RNF168 SH3RF1 MYCBP2 SH3RF2 TRIM55 TRIM54 BIRC3 RBCK1	8.23e-09	305	51	10	SM00184
Domain	zf-C3HC4	RNF166 TRIM67 RNF168 SH3RF1 IRF2BP1 SH3RF2 TRIM55 TRIM54 RBCK1	8.26e-09	223	51	9	PF00097
Domain	Znf-RING_LisH	RNF166 SH3RF2 TRIM55 TRIM54 RBCK1	3.25e-08	34	51	5	IPR027370
Domain	zf-RING_UBOX	RNF166 SH3RF2 TRIM55 TRIM54 RBCK1	3.25e-08	34	51	5	PF13445
Domain	Znf_RING_CS	RNF166 TRIM67 SH3RF1 SH3RF2 TRIM55 TRIM54 RBCK1	2.84e-07	163	51	7	IPR017907
Domain	ZF_BBOX	TRIM67 MYCBP2 TRIM55 TRIM54 RBCK1	2.56e-06	80	51	5	PS50119
Domain	Znf_B-box	TRIM67 MYCBP2 TRIM55 TRIM54 RBCK1	2.72e-06	81	51	5	IPR000315
Domain	COS_domain	TRIM67 TRIM55 TRIM54	4.15e-06	12	51	3	IPR017903
Domain	COS	TRIM67 TRIM55 TRIM54	4.15e-06	12	51	3	PS51262
Domain	ZnF_NFX	NFXL1 ZNFX1	2.19e-05	3	51	2	SM00438
Domain	zf-NF-X1	NFXL1 ZNFX1	2.19e-05	3	51	2	PF01422
Domain	Znf_NFX1	NFXL1 ZNFX1	2.19e-05	3	51	2	IPR000967
Domain	Notch	NOTCH2 NOTCH4	4.37e-05	4	51	2	IPR008297
Domain	NODP	NOTCH2 NOTCH4	4.37e-05	4	51	2	PF07684
Domain	Notch_NODP_dom	NOTCH2 NOTCH4	4.37e-05	4	51	2	IPR011656
Domain	Notch_NOD_dom	NOTCH2 NOTCH4	4.37e-05	4	51	2	IPR010660
Domain	NOD	NOTCH2 NOTCH4	4.37e-05	4	51	2	PF06816
Domain	NOD	NOTCH2 NOTCH4	4.37e-05	4	51	2	SM01338
Domain	NODP	NOTCH2 NOTCH4	4.37e-05	4	51	2	SM01339
Domain	LNR	NOTCH2 NOTCH4	7.27e-05	5	51	2	PS50258
Domain	Notch_dom	NOTCH2 NOTCH4	1.52e-04	7	51	2	IPR000800
Domain	Notch	NOTCH2 NOTCH4	1.52e-04	7	51	2	PF00066
Domain	NL	NOTCH2 NOTCH4	1.52e-04	7	51	2	SM00004
Domain	EGF_3	TENM4 ADAM20 LRP2 NOTCH2 NOTCH4	4.43e-04	235	51	5	PS50026
Domain	EGF-like_dom	TENM4 ADAM20 LRP2 NOTCH2 NOTCH4	5.76e-04	249	51	5	IPR000742
Domain	EGF_1	TENM4 ADAM20 LRP2 NOTCH2 NOTCH4	6.42e-04	255	51	5	PS00022
Domain	TIL_dom	LRP2 BMPER	6.51e-04	14	51	2	IPR002919
Domain	EGF-like_CS	TENM4 ADAM20 LRP2 NOTCH2 NOTCH4	7.13e-04	261	51	5	IPR013032
Domain	EGF_2	TENM4 ADAM20 LRP2 NOTCH2 NOTCH4	7.63e-04	265	51	5	PS01186
Domain	Disintegrin_CS	ADAM20 ADAM7	8.56e-04	16	51	2	IPR018358
Domain	Growth_fac_rcpt_	INSR LRP2 NOTCH2 NOTCH4	8.62e-04	156	51	4	IPR009030
Domain	BBOX	TRIM67 TRIM55 TRIM54	8.85e-04	69	51	3	SM00336
Domain	-	TRIM67 TRIM55 TRIM54	9.62e-04	71	51	3	4.10.45.10
Domain	zf-B_box	TRIM67 TRIM55 TRIM54	1.00e-03	72	51	3	PF00643
Domain	ADAM_CR	ADAM20 ADAM7	1.09e-03	18	51	2	PF08516
Domain	-	ADAM20 ADAM7	1.35e-03	20	51	2	4.10.70.10
Domain	Disintegrin	ADAM20 ADAM7	1.49e-03	21	51	2	PF00200
Domain	DISIN	ADAM20 ADAM7	1.49e-03	21	51	2	SM00050
Domain	EGF_CA	LRP2 NOTCH2 NOTCH4	1.67e-03	86	51	3	PF07645
Domain	EGF_Ca-bd_CS	LRP2 NOTCH2 NOTCH4	2.36e-03	97	51	3	IPR018097
Domain	ACR	ADAM20 ADAM7	2.46e-03	27	51	2	SM00608
Domain	ADAM_Cys-rich	ADAM20 ADAM7	2.46e-03	27	51	2	IPR006586
Domain	EGF_CA	LRP2 NOTCH2 NOTCH4	2.50e-03	99	51	3	PS01187
Domain	ASX_HYDROXYL	LRP2 NOTCH2 NOTCH4	2.57e-03	100	51	3	PS00010
Domain	hEGF	NOTCH2 NOTCH4	2.64e-03	28	51	2	PF12661
Domain	EGF-type_Asp/Asn_hydroxyl_site	LRP2 NOTCH2 NOTCH4	3.04e-03	106	51	3	IPR000152
Domain	EGF	TENM4 LRP2 NOTCH2 NOTCH4	3.84e-03	235	51	4	SM00181
Domain	EGF_CA	LRP2 NOTCH2 NOTCH4	4.51e-03	122	51	3	SM00179
Domain	EGF-like_Ca-bd_dom	LRP2 NOTCH2 NOTCH4	4.72e-03	124	51	3	IPR001881
Domain	EGF	LRP2 NOTCH2 NOTCH4	4.93e-03	126	51	3	PF00008
Domain	Peptidase_M12B_N	ADAM20 ADAM7	5.08e-03	39	51	2	IPR002870
Domain	Pep_M12B_propep	ADAM20 ADAM7	5.08e-03	39	51	2	PF01562
Domain	-	TENM4 LRP2	5.08e-03	39	51	2	2.120.10.30
Domain	DISINTEGRIN_1	ADAM20 ADAM7	5.34e-03	40	51	2	PS00427
Domain	LDLR_class-A_CS	RXFP2 LRP2	5.34e-03	40	51	2	IPR023415
Domain	Reprolysin	ADAM20 ADAM7	5.34e-03	40	51	2	PF01421
Domain	ADAM_MEPRO	ADAM20 ADAM7	5.34e-03	40	51	2	PS50215
Domain	DISINTEGRIN_2	ADAM20 ADAM7	5.34e-03	40	51	2	PS50214
Domain	Peptidase_M12B	ADAM20 ADAM7	5.34e-03	40	51	2	IPR001590
Pathway	REACTOME_NOTCH4_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION	CREBBP NOTCH2 NOTCH4	1.30e-05	20	33	3	M27881
Pathway	REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY	CREBBP NOTCH2 NOTCH4	3.68e-05	28	33	3	M6177
Pathway	REACTOME_DEFECTIVE_LFNG_CAUSES_SCDO3	NOTCH2 NOTCH4	5.29e-05	5	33	2	M27411
Pathway	REACTOME_PRE_NOTCH_PROCESSING_IN_THE_ENDOPLASMIC_RETICULUM	NOTCH2 NOTCH4	7.92e-05	6	33	2	M27068
Pathway	WP_NOTCH_SIGNALING_WP268	CREBBP NOTCH2 NOTCH4	1.55e-04	45	33	3	M39571
Pathway	WP_NOTCH_SIGNALING_PATHWAY	CREBBP NOTCH2 NOTCH4	1.66e-04	46	33	3	MM15971
Pathway	KEGG_NOTCH_SIGNALING_PATHWAY	CREBBP NOTCH2 NOTCH4	1.77e-04	47	33	3	M7946
Pathway	KEGG_MEDICUS_REFERENCE_NOTCH_PROTEOLYTIC_ACTIVATION	NOTCH2 NOTCH4	2.88e-04	11	33	2	M47865
Pathway	KEGG_MEDICUS_PATHOGEN_HPV_E6_TO_NOTCH_SIGNALING_PATHWAY_N00380	NOTCH2 NOTCH4	3.46e-04	12	33	2	M47532
Pathway	KEGG_MEDICUS_PATHOGEN_HPV_E6_TO_NOTCH_SIGNALING_PATHWAY_N00381	NOTCH2 NOTCH4	3.46e-04	12	33	2	M47533
Pathway	KEGG_MEDICUS_REFERENCE_NOTCH_SIGNALING_PATHWAY	NOTCH2 NOTCH4	4.08e-04	13	33	2	M47423
Pathway	KEGG_MEDICUS_PATHOGEN_HPV_E6_TO_NOTCH_SIGNALING_PATHWAY_N00382	NOTCH2 NOTCH4	4.08e-04	13	33	2	M47534
Pathway	REACTOME_PRE_NOTCH_PROCESSING_IN_GOLGI	NOTCH2 NOTCH4	7.94e-04	18	33	2	M614
Pathway	REACTOME_SIGNALING_BY_NOTCH4	CREBBP NOTCH2 NOTCH4	9.13e-04	82	33	3	M594
Pubmed	Activity-based E3 ligase profiling uncovers an E3 ligase with esterification activity.	UBR1 RNF168 IRF2BP1 MYCBP2 TRIM55 RBCK1	5.77e-09	95	51	6	29643511
Pubmed	A comprehensive framework of E2-RING E3 interactions of the human ubiquitin-proteasome system.	RNF166 RNF168 SH3RF2 TRIM54 BIRC3	8.56e-07	118	51	5	19690564
Pubmed	Notch receptors and hematopoiesis.	NOTCH2 NOTCH4	2.11e-06	2	51	2	11532344
Pubmed	Assessing the role of SH3RF1 and SH3RF2 polymorphisms in susceptibility to tuberculosis: A case-control study in the Han Chinese population.	SH3RF1 SH3RF2	2.11e-06	2	51	2	33129950
Pubmed	Muscle RING-finger 2 and 3 maintain striated-muscle structure and function.	TRIM55 TRIM54	2.11e-06	2	51	2	27493870
Pubmed	notch2, notch4 gene polymorphisms in psoriasis vulgaris.	NOTCH2 NOTCH4	2.11e-06	2	51	2	23587900
Pubmed	Inflammation dysregulates Notch signaling in endothelial cells: implication of Notch2 and Notch4 to endothelial dysfunction.	NOTCH2 NOTCH4	2.11e-06	2	51	2	20643108
Pubmed	Functional proteomics mapping of a human signaling pathway.	CNKSR1 MTMR4 RNF168 IRF2BP1 MYCBP2 CREBBP ANKRD27 NOTCH2	2.22e-06	591	51	8	15231748
Pubmed	Sh3rf2/POSHER protein promotes cell survival by ring-mediated proteasomal degradation of the c-Jun N-terminal kinase scaffold POSH (Plenty of SH3s) protein.	SH3RF1 SH3RF2	6.32e-06	3	51	2	22128169
Pubmed	Differential expression of Notch genes in human osteoblastic cells.	NOTCH2 NOTCH4	6.32e-06	3	51	2	11836628
Pubmed	Nuclear-cytoplasmic shuttling of a RING-IBR protein RBCK1 and its functional interaction with nuclear body proteins.	CREBBP RBCK1	6.32e-06	3	51	2	15833741
Pubmed	Integrity of intracellular domain of Notch ligand is indispensable for cleavage required for release of the Notch2 intracellular domain.	NOTCH2 NOTCH4	6.32e-06	3	51	2	11823422
Pubmed	Notch signaling: cell fate control and signal integration in development.	NOTCH2 NOTCH4	6.32e-06	3	51	2	10221902
Pubmed	Electrostatic Similarity Analysis of Human β-Defensin Binding in the Melanocortin System.	DEFB4A MC1R	6.32e-06	3	51	2	26536271
Pubmed	Prognostic roles of mRNA expression of notch receptors in non-small cell lung cancer.	NOTCH2 NOTCH4	1.26e-05	4	51	2	28061457
Pubmed	The 4 Notch receptors play distinct and antagonistic roles in the proliferation and hepatocytic differentiation of liver progenitors.	NOTCH2 NOTCH4	1.26e-05	4	51	2	24145721
Pubmed	A switch in Notch gene expression parallels stem cell to endothelial transition in infantile hemangioma.	NOTCH2 NOTCH4	1.26e-05	4	51	2	20069356
Pubmed	Expression and clinical significance of Notch receptors in human renal cell carcinoma.	NOTCH2 NOTCH4	1.26e-05	4	51	2	19404845
Pubmed	Notch signaling pathway regulates the growth and the expression of inflammatory cytokines in mouse basophils.	NOTCH2 NOTCH4	1.26e-05	4	51	2	28669409
Pubmed	Evolutionary analysis of vertebrate Notch genes.	NOTCH2 NOTCH4	1.26e-05	4	51	2	11466531
Pubmed	Abnormal expression pattern of Notch receptors, ligands, and downstream effectors in the dorsolateral prefrontal cortex and amygdala of suicidal victims.	NOTCH2 NOTCH4	1.26e-05	4	51	2	24151014
Pubmed	Characterization and developmental expression of the amphioxus homolog of Notch (AmphiNotch): evolutionary conservation of multiple expression domains in amphioxus and vertebrates.	NOTCH2 NOTCH4	1.26e-05	4	51	2	11401408
Pubmed	The E3 ubiquitin ligases HOIP and cIAP1 are recruited to the TNFR2 signaling complex and mediate TNFR2-induced canonical NF-κB signaling.	BIRC3 RBCK1	1.26e-05	4	51	2	29378181
Pubmed	Notch as a mediator of cell fate determination in hematopoiesis: evidence and speculation.	NOTCH2 NOTCH4	1.26e-05	4	51	2	10194420
Pubmed	Functional conservation of mouse Notch receptor family members.	NOTCH2 NOTCH4	1.26e-05	4	51	2	8898100
Pubmed	Conservation of the biochemical mechanisms of signal transduction among mammalian Notch family members.	NOTCH2 NOTCH4	1.26e-05	4	51	2	11459941
Pubmed	Mutational analysis of NOTCH1, 2, 3 and 4 genes in common solid cancers and acute leukemias.	NOTCH2 NOTCH4	1.26e-05	4	51	2	18184405
Pubmed	Identification of muscle specific ring finger proteins as potential regulators of the titin kinase domain.	TRIM55 TRIM54	1.26e-05	4	51	2	11243782
Pubmed	Notch signaling in the mammalian central nervous system: insights from mouse mutants.	NOTCH2 NOTCH4	1.26e-05	4	51	2	15917835
Pubmed	CBP mediates NF-κB-dependent histone acetylation and estrogen receptor recruitment to an estrogen response element in the BIRC3 promoter.	BIRC3 CREBBP	1.26e-05	4	51	2	22083956
Pubmed	Notch pathway activity identifies cells with cancer stem cell-like properties and correlates with worse survival in lung adenocarcinoma.	NOTCH2 NOTCH4	1.26e-05	4	51	2	23444212
Pubmed	Deregulated expression of Notch receptors in human hepatocellular carcinoma.	NOTCH2 NOTCH4	1.26e-05	4	51	2	17920003
Pubmed	Systematic analysis of dimeric E3-RING interactions reveals increased combinatorial complexity in human ubiquitination networks.	RNF166 TRIM55 BIRC3 RBCK1	1.76e-05	105	51	4	22493164
Pubmed	Expression patterns of Notch receptors and their ligands Jagged and Delta in human placenta.	NOTCH2 NOTCH4	2.10e-05	5	51	2	21726900
Pubmed	Notch and MAML-1 complexation do not detectably alter the DNA binding specificity of the transcription factor CSL.	NOTCH2 NOTCH4	2.10e-05	5	51	2	21124806
Pubmed	Intraovarian regulation of gonadotropin-dependent folliculogenesis depends on notch receptor signaling pathways not involving Delta-like ligand 4 (Dll4).	NOTCH2 NOTCH4	2.10e-05	5	51	2	23675950
Pubmed	MAML1, a human homologue of Drosophila mastermind, is a transcriptional co-activator for NOTCH receptors.	NOTCH2 NOTCH4	2.10e-05	5	51	2	11101851
Pubmed	Functional redundancy of the Notch gene family during mouse embryogenesis: analysis of Notch gene expression in Notch3-deficient mice.	NOTCH2 NOTCH4	2.10e-05	5	51	2	15882997
Pubmed	Association of Notch pathway down-regulation with Triple Negative/Basal-like breast carcinomas and high tumor-infiltrating FOXP3+ Tregs.	NOTCH2 NOTCH4	2.10e-05	5	51	2	27118257
Pubmed	RBP-L, a transcription factor related to RBP-Jkappa.	NOTCH2 NOTCH4	3.15e-05	6	51	2	9111338
Pubmed	Notch signaling is a critical regulator of allogeneic CD4+ T-cell responses mediating graft-versus-host disease.	NOTCH2 NOTCH4	3.15e-05	6	51	2	20870902
Pubmed	Characterization of Notch receptor expression in the developing mammalian heart and liver.	NOTCH2 NOTCH4	3.15e-05	6	51	2	12244553
Pubmed	Hairy-related transcription factors inhibit Notch-induced smooth muscle alpha-actin expression by interfering with Notch intracellular domain/CBF-1 complex interaction with the CBF-1-binding site.	NOTCH2 NOTCH4	3.15e-05	6	51	2	18239137
Pubmed	Notch4 Negatively Regulates the Inflammatory Response to Mycobacterium tuberculosis Infection by Inhibiting TAK1 Activation.	NOTCH2 NOTCH4	3.15e-05	6	51	2	29228365
Pubmed	Epidermal growth factor-like domain 7 (EGFL7) modulates Notch signalling and affects neural stem cell renewal.	NOTCH2 NOTCH4	3.15e-05	6	51	2	19503073
Pubmed	Interaction with factor inhibiting HIF-1 defines an additional mode of cross-coupling between the Notch and hypoxia signaling pathways.	NOTCH2 NOTCH4	3.15e-05	6	51	2	18299578
Pubmed	Cloning and functional characterization of the murine mastermind-like 1 (Maml1) gene.	NOTCH2 NOTCH4	3.15e-05	6	51	2	15019995
Pubmed	Notch controls the magnitude of T helper cell responses by promoting cellular longevity.	NOTCH2 NOTCH4	3.15e-05	6	51	2	22615412
Pubmed	E3-ligase knock down revealed differential titin degradation by autopagy and the ubiquitin proteasome system.	TRIM55 TRIM54	3.15e-05	6	51	2	34702928
Pubmed	Notch lineages and activity in intestinal stem cells determined by a new set of knock-in mice.	NOTCH2 NOTCH4	3.15e-05	6	51	2	21991352
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	MYCBP2 TRPS1 NUP88 LRP2 RREB1 ZBTB1	3.32e-05	418	51	6	34709266
Pubmed	The notch pathway positively regulates programmed cell death during erythroid differentiation.	BIRC3 NOTCH2 NOTCH4	3.77e-05	44	51	3	17476283
Pubmed	An atlas of combinatorial transcriptional regulation in mouse and man.	GSX1 IRF2BP1 TRPS1 OLIG1 ZBTB1 CREBBP ZBTB24 KDM4B	3.86e-05	877	51	8	20211142
Pubmed	Human ligands of the Notch receptor.	NOTCH2 NOTCH4	4.41e-05	7	51	2	10079256
Pubmed	Muscle-specific RING finger-1 interacts with titin to regulate sarcomeric M-line and thick filament structure and may have nuclear functions via its interaction with glucocorticoid modulatory element binding protein-1.	TRIM55 TRIM54	4.41e-05	7	51	2	11927605
Pubmed	The distribution of Notch receptors and their ligands during articular cartilage development.	NOTCH2 NOTCH4	4.41e-05	7	51	2	12846471
Pubmed	Murine notch homologs (N1-4) undergo presenilin-dependent proteolysis.	NOTCH2 NOTCH4	4.41e-05	7	51	2	11518718
Pubmed	A census of human transcription factors: function, expression and evolution.	GSX1 GCM2 TRPS1 NFXL1 ZNFX1 RREB1 OLIG1 ZBTB24	4.93e-05	908	51	8	19274049
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	CMIP MYCBP2 INSR TRPS1 TMEM63B TSEN2 CREBBP NOTCH2 KDM4B CPNE7	5.15e-05	1489	51	10	28611215
Pubmed	Cranial neural crest ablation of Jagged1 recapitulates the craniofacial phenotype of Alagille syndrome patients.	NOTCH2 NOTCH4	5.87e-05	8	51	2	22156581
Pubmed	Notch1 and Jagged1 expression by the developing pulmonary vasculature.	NOTCH2 NOTCH4	5.87e-05	8	51	2	12242716
Pubmed	Distinct expression patterns of notch family receptors and ligands during development of the mammalian inner ear.	NOTCH2 NOTCH4	5.87e-05	8	51	2	9858718
Pubmed	Mapping a dynamic innate immunity protein interaction network regulating type I interferon production.	UBR1 IRF2BP1 NFXL1 CREBBP RBCK1	5.96e-05	283	51	5	21903422
Pubmed	Dynamic expression patterns of the pudgy/spondylocostal dysostosis gene Dll3 in the developing nervous system.	NOTCH2 NOTCH4	7.54e-05	9	51	2	11118901
Pubmed	Notch1 signals through Jagged2 to regulate apoptosis in the apical ectodermal ridge of the developing limb bud.	NOTCH2 NOTCH4	7.54e-05	9	51	2	16245338
Pubmed	Identification of a family of mastermind-like transcriptional coactivators for mammalian notch receptors.	NOTCH2 NOTCH4	7.54e-05	9	51	2	12370315
Pubmed	Developmental regulation of MURF ubiquitin ligases and autophagy proteins nbr1, p62/SQSTM1 and LC3 during cardiac myofibril assembly and turnover.	TRIM55 TRIM54	7.54e-05	9	51	2	21185285
Pubmed	A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract.	SH3RF1 GCM2 TRPS1 ZFP57 ZBTB1 CREBBP KDM4B	7.55e-05	709	51	7	22988430
Pubmed	The seventh zinc finger motif of A20 is required for the suppression of TNF-α-induced apoptosis.	BIRC3 RBCK1	9.42e-05	10	51	2	25911380
Pubmed	Spatiotemporal expression of Notch receptors and ligands in developing mouse placenta.	NOTCH2 NOTCH4	9.42e-05	10	51	2	23665443
Pubmed	Notch4 signaling limits regulatory T-cell-mediated tissue repair and promotes severe lung inflammation in viral infections.	NOTCH2 NOTCH4	9.42e-05	10	51	2	33915108
Pubmed	Jag2-Notch1 signaling regulates oral epithelial differentiation and palate development.	NOTCH2 NOTCH4	1.15e-04	11	51	2	16607638
Pubmed	Coexpression of Cux-1 and Notch signaling pathway components during kidney development.	NOTCH2 NOTCH4	1.15e-04	11	51	2	15499562
Pubmed	A forward genetic screen in mice identifies mutants with abnormal cortical patterning.	MYCBP2 LRP2	1.15e-04	11	51	2	23968836
Pubmed	Localisation of members of the notch system and the differentiation of vibrissa hair follicles: receptors, ligands, and fringe modulators.	NOTCH2 NOTCH4	1.15e-04	11	51	2	10878608
Pubmed	A family of mammalian Fringe genes implicated in boundary determination and the Notch pathway.	NOTCH2 NOTCH4	1.15e-04	11	51	2	9187150
Pubmed	Notch-associated gene expression in embryonic and adult taste papillae and taste buds suggests a role in taste cell lineage decisions.	NOTCH2 NOTCH4	1.15e-04	11	51	2	12866128
Pubmed	Basic helix-loop-helix transcription factors regulate the neuroendocrine differentiation of fetal mouse pulmonary epithelium.	NOTCH2 NOTCH4	1.38e-04	12	51	2	10952889
Pubmed	The ubiquitin ligase XIAP recruits LUBAC for NOD2 signaling in inflammation and innate immunity.	BIRC3 RBCK1	1.38e-04	12	51	2	22607974
Pubmed	Genome-wide isolation of growth and obesity QTL using mouse speed congenic strains.	UBR1 RBCK1	1.38e-04	12	51	2	16670015
Pubmed	Developmental expression of the Notch signaling pathway genes during mouse preimplantation development.	NOTCH2 NOTCH4	1.38e-04	12	51	2	15465494
Pubmed	Local anesthetics impair the growth and self-renewal of glioblastoma stem cells by inhibiting ZDHHC15-mediated GP130 palmitoylation.	TENM4 LRP2 NFXL1	1.58e-04	71	51	3	33541421
Pubmed	A regulatory T cell Notch4-GDF15 axis licenses tissue inflammation in asthma.	NOTCH2 NOTCH4	1.63e-04	13	51	2	32929274
Pubmed	Vascular expression of Notch pathway receptors and ligands is restricted to arterial vessels.	NOTCH2 NOTCH4	1.63e-04	13	51	2	11578869
Pubmed	Inhibition of notch1-dependent cardiomyogenesis leads to a dilated myopathy in the neonatal heart.	NOTCH2 NOTCH4	1.63e-04	13	51	2	20558824
Pubmed	--LUBAC deficiency perturbs TLR3 signaling to cause immunodeficiency and autoinflammation.	BIRC3 RBCK1	1.63e-04	13	51	2	27810922
Pubmed	Cell-fate transition and determination analysis of mouse male germ cells throughout development.	NOTCH2 NOTCH4	1.90e-04	14	51	2	34824237
Pubmed	Math1 controls cerebellar granule cell differentiation by regulating multiple components of the Notch signaling pathway.	NOTCH2 NOTCH4	1.90e-04	14	51	2	14757642
Pubmed	Hundreds of variants clustered in genomic loci and biological pathways affect human height.	INSR ZNFX1 GPC5 ZBTB24	2.07e-04	198	51	4	20881960
Pubmed	Mouse Fbw7/Sel-10/Cdc4 is required for notch degradation during vascular development.	NOTCH2 NOTCH4	2.19e-04	15	51	2	14672936
Pubmed	Expression of Notch pathway genes in the embryonic mouse metanephros suggests a role in proximal tubule development.	NOTCH2 NOTCH4	2.19e-04	15	51	2	12971992
Pubmed	FBXO45-MYCBP2 regulates mitotic cell fate by targeting FBXW7 for degradation.	MYCBP2 NOTCH2	2.19e-04	15	51	2	31285543
Pubmed	Identification of Thymosin β4 as an effector of Hand1-mediated vascular development.	NOTCH2 NOTCH4	2.19e-04	15	51	2	20975697
Pubmed	Expression of Notch pathway components in fetal and adult mouse small intestine.	NOTCH2 NOTCH4	2.50e-04	16	51	2	12617809
Pubmed	Notch gene expression during pancreatic organogenesis.	NOTCH2 NOTCH4	2.50e-04	16	51	2	10842072
Pubmed	YOD1/TRAF6 association balances p62-dependent IL-1 signaling to NF-κB.	RNF168 BIRC3	2.50e-04	16	51	2	28244869
Pubmed	An essential role for Notch in neural crest during cardiovascular development and smooth muscle differentiation.	NOTCH2 NOTCH4	2.50e-04	16	51	2	17273555
Pubmed	Requirement of Math1 for secretory cell lineage commitment in the mouse intestine.	NOTCH2 NOTCH4	2.50e-04	16	51	2	11739954
Pubmed	Transcriptional Regulator ZEB2 Is Essential for Bergmann Glia Development.	OLIG1 NOTCH2	2.50e-04	16	51	2	29326173
Pubmed	Multiple dorsoventral origins of oligodendrocyte generation in the spinal cord and hindbrain.	GSX1 OLIG1	2.50e-04	16	51	2	15629702
Interaction	UBE2D3 interactions	RNF166 TRIM67 RNF168 SH3RF1 MYCBP2 TRIM55 TRIM54 BIRC3 RBCK1	3.40e-08	283	51	9	int:UBE2D3
Interaction	UBE2D1 interactions	UBR1 RNF166 RNF168 SH3RF1 TRIM55 TRIM54 BIRC3 CREBBP RBCK1	4.71e-08	294	51	9	int:UBE2D1
Interaction	UBE2D2 interactions	UBR1 RNF166 TRIM67 RNF168 MYCBP2 TRIM55 TRIM54 BIRC3 RBCK1	9.21e-08	318	51	9	int:UBE2D2
Interaction	YOD1 interactions	ZFP57 TRIM55 TRIM54 BIRC3 RBCK1	9.07e-07	70	51	5	int:YOD1
Interaction	UBE2L3 interactions	TRIM67 RNF168 IRF2BP1 MYCBP2 TRIM55 BIRC3 RBCK1	9.78e-07	211	51	7	int:UBE2L3
Interaction	XAF1 interactions	RNF166 TRIM54 BIRC3 CREBBP	3.79e-06	42	51	4	int:XAF1
Interaction	KIF5A interactions	TRIM67 INSR TRIM55 CREBBP ANKRD27	4.83e-06	98	51	5	int:KIF5A
Interaction	MAML2 interactions	CREBBP NOTCH2 NOTCH4	1.01e-05	17	51	3	int:MAML2
Interaction	GLI4 interactions	MTMR4 TRIM55 LRP2 ZBTB24 NOTCH2	1.58e-05	125	51	5	int:GLI4
Interaction	MAML3 interactions	ZBTB1 NOTCH2 NOTCH4	1.69e-05	20	51	3	int:MAML3
Interaction	KDM1A interactions	TRIM67 RNF168 MYCBP2 TRPS1 NUP88 LRP2 TRIM54 BIRC3 RREB1 ZBTB1 ZBTB24	1.86e-05	941	51	11	int:KDM1A
Interaction	RAD23A interactions	TRIM67 SH3RF1 SH3RF2 TRIM55 TRIM54 CREBBP	2.09e-05	224	51	6	int:RAD23A
Interaction	POLD1 interactions	MTMR4 TRIM67 TRIM55 BIRC3 TSEN2 ZBTB24 RBCK1	2.11e-05	337	51	7	int:POLD1
Interaction	UBE2N interactions	TRIM67 RNF168 SH3RF1 SH3RF2 TRIM54 BIRC3 RBCK1	2.74e-05	351	51	7	int:UBE2N
Interaction	NTN5 interactions	MTMR4 LRP2 NOTCH2	2.98e-05	24	51	3	int:NTN5
Interaction	IGFL3 interactions	MYCBP2 INSR LRP2 NOTCH2	3.87e-05	75	51	4	int:IGFL3
Interaction	USP35 interactions	TRIM67 TRIM54 BIRC3	4.78e-05	28	51	3	int:USP35
Interaction	CMIP interactions	CMIP TRIM67 TRIM54	5.91e-05	30	51	3	int:CMIP
Interaction	ZNF667-AS1 interactions	TRIM55 TRIM54	6.25e-05	5	51	2	int:ZNF667-AS1
Interaction	TEAD1 interactions	IRF2BP1 INSR TRPS1 RREB1 CREBBP	8.14e-05	176	51	5	int:TEAD1
Interaction	NUP35 interactions	GSX1 RNF166 TRIM67 IRF2BP1 NUP88 BIRC3 CREBBP	9.04e-05	424	51	7	int:NUP35
Interaction	SHFL interactions	UBR1 TENM4 TRIM55 RBCK1	1.06e-04	97	51	4	int:SHFL
Interaction	GREM2 interactions	UBR1 LRP2 NOTCH2	1.12e-04	37	51	3	int:GREM2
Interaction	TNFAIP3 interactions	RNF166 TRIM67 RNF168 BIRC3 RBCK1	1.20e-04	191	51	5	int:TNFAIP3
Interaction	TMEM68 interactions	MTMR4 TRIM67 TMEM63B	1.41e-04	40	51	3	int:TMEM68
Interaction	RABGEF1 interactions	UBR1 TRIM67 RNF168 TRIM54 RBCK1	1.63e-04	204	51	5	int:RABGEF1
Interaction	IGF2 interactions	UBR1 INSR TRIM55	1.63e-04	42	51	3	int:IGF2
Interaction	TRIP10 interactions	TRIM67 TSEN2 CREBBP KDM4B	1.66e-04	109	51	4	int:TRIP10
Interaction	BMPER interactions	BMPER NOTCH2	1.74e-04	8	51	2	int:BMPER
Interaction	ADAM7 interactions	MYCBP2 ADAM7 TSEN2	1.75e-04	43	51	3	int:ADAM7
Interaction	PAX8 interactions	GCM2 IRF2BP1 TRPS1 CREBBP	1.78e-04	111	51	4	int:PAX8
Interaction	NFIC interactions	TRIM67 TRPS1 MC1R RREB1 CREBBP	1.86e-04	210	51	5	int:NFIC
Interaction	ICAM4 interactions	MYCBP2 TSEN2 SLC5A4	2.15e-04	46	51	3	int:ICAM4
Interaction	IRF9 interactions	GSX1 IRF2BP1 CREBBP	2.29e-04	47	51	3	int:IRF9
Interaction	NUP98 interactions	RNF166 TRIM67 NUP88 BIRC3 CREBBP	2.31e-04	220	51	5	int:NUP98
Interaction	SULF2 interactions	UBR1 TRIM67 LRP2 NOTCH2	2.33e-04	119	51	4	int:SULF2
Interaction	SLC25A22 interactions	TRIM67 INSR NFXL1 BIRC3	2.56e-04	122	51	4	int:SLC25A22
Cytoband	16q24.3	RNF166 MC1R CPNE7	2.75e-05	52	51	3	16q24.3
Cytoband	Ensembl 112 genes in cytogenetic band chr16q24	RNF166 MC1R CPNE7	4.77e-04	136	51	3	chr16q24
GeneFamily	Ring finger proteins	RNF166 TRIM67 RNF168 SH3RF1 SH3RF2 TRIM55 TRIM54 BIRC3 RBCK1	1.37e-08	275	43	9	58
GeneFamily	Ring finger proteins\|Tripartite motif containing\|ARF GTPase family	TRIM67 TRIM55 TRIM54	1.49e-03	95	43	3	59
GeneFamily	ADAM metallopeptidase domain containing\|CD molecules	ADAM20 ADAM7	1.87e-03	27	43	2	47
Disease	sunburn	RNF166 TRPS1 MC1R NOTCH2	2.34e-05	96	51	4	EFO_0003958
Disease	suntan	RNF166 TRPS1 MC1R CPNE7	3.08e-05	103	51	4	EFO_0004279
Disease	melanocyte protein PMEL measurement	MAN2A1 MC1R	8.15e-05	8	51	2	EFO_0801792
Disease	S-7-hydroxywarfarin to S-warfarin ratio measurement	RNF168 RXFP2 TRPS1	3.77e-04	81	51	3	EFO_0803334
Disease	age at first sexual intercourse measurement	GSX1 TENM4 TRPS1 KDM4B CPNE7	5.16e-04	383	51	5	EFO_0009749
Disease	neutrophil count	CMIP MYCBP2 ZFP57 NUP88 RREB1 CREBBP NOTCH2 KDM4B NOTCH4	5.43e-04	1382	51	9	EFO_0004833
Disease	urate measurement	GJA9 CMIP INSR LRP2 RREB1 NOTCH2 KDM4B	8.35e-04	895	51	7	EFO_0004531
Disease	Neonatal diabetes mellitus	INSR ZFP57	8.57e-04	25	51	2	C0158981
Disease	Child Development Disorders, Specific	LRP2 KCNT1	1.15e-03	29	51	2	C0085997
Disease	Child Development Deviations	LRP2 KCNT1	1.15e-03	29	51	2	C0085996
Disease	Developmental Disabilities	LRP2 KCNT1	1.24e-03	30	51	2	C0008073
Disease	Squamous cell carcinoma	CREBBP NOTCH2 NOTCH4	1.30e-03	124	51	3	C0007137
Disease	nicotine dependence symptom count	GCM2 MYCBP2 RXFP2 SLC5A4	1.49e-03	285	51	4	EFO_0009262
Disease	cutaneous squamous cell carcinoma	TRPS1 MC1R	1.49e-03	33	51	2	EFO_1001927
Disease	hyperuricemia	LRP2 RREB1	1.49e-03	33	51	2	EFO_0009104
Disease	very low density lipoprotein cholesterol measurement, phospholipids:total lipids ratio	CMIP TENM4 IRF2BP1 TRPS1	1.61e-03	291	51	4	EFO_0008317, EFO_0020946
Disease	diabetic retinopathy	MAN2A1 INSR TRPS1	1.70e-03	136	51	3	EFO_0003770

Protein segments in the cluster

Peptide	Gene	Start	Entry
KDPCCLLNCTLHPGA	ADAM20	431	O43506
NPCCDAHTCVLKPGF	ADAM7	426	Q9H2U9
NHPPPDLCEFFCKHC	CMIP	236	Q8IY22
NCTRHDCPVCLPLKN	CREBBP	421	Q92793
PCGHLVVCKDCAPSL	BIRC3	571	Q13489
CLKSGAICHPVFCPR	DEFB4A	31	O15263
LCPEHPTCGCIFKNF	MC1R	266	Q01726
ADPEFCHPLCQCPKC	ANKRD27	706	Q96NW4
TCIDLVNHFKCSCPP	NOTCH2	1201	Q04721
IPHTCGPDPKICCQF	MAN2A1	356	Q16706
PCQKVLEKCGHLCPA	NFXL1	581	Q6ZNB6
QYCPHCQGLALTKPC	GPC5	256	P78333
CPVCFHVNCLLCKAI	RBCK1	391	Q9BYM8
TLCHLLPVKAPFCCL	KCNT1	746	Q5JUK3
ACHARKAGLLCVCPL	GSX1	46	Q9H4S2
PLIACGKCCLQVHAS	KDM4B	756	O94953
LCFALPGLHTPKCDC	LRP2	2356	P98164
CLGPCPKVCHLLEGE	INSR	331	P06213
GPGLCTCAVCKFPHL	OLIG1	241	Q8TAK6
NVFCAGCCHLKLPIP	MTMR4	1141	Q9NYA4
MVPPKLHVLFCLCGC	PLA2G7	1	Q13093
NKPCVAGCHCPANLV	BMPER	656	Q8N8U9
LFKCHGHPCPNIIDC	GJA9	186	P57773
VLGPAGHCAKHFLCC	CPNE7	136	Q9UBL6
INPKPCGHLCCCVVR	TMEM63B	311	Q5T3F8
IGCPLVCGAVFHSCK	FBXO30	31	Q8TB52
VQCPSVPGHKFCFPC	IRF2BP1	516	Q8IU81
KCFVEHILCTKPLPC	NUP88	446	Q99567
PLPHVCCCKQDALIL	TSEN2	216	Q8NCE0
HTFCGECLQPCLQVP	RNF166	51	Q96A37
KACPNCHSALELIPC	GCM2	116	O75603
PCGNLTKCLPRAFHC	RXFP2	51	Q8WXD0
CLAPSNCPKIICGVH	SLC5A4	511	Q9NY91
PCGGVKNEEHCLPCL	MYCBP2	4396	O75592
CQDQPGAFHCKCLPG	NOTCH4	566	Q99466
LPCQHTFCKRCLLGI	SH3RF1	26	Q7Z6J0
HVAGICHNILVCCPK	CNKSR1	176	Q969H4
PVVILPCQHNLCRKC	TRIM54	36	Q9BYV2
IKHCPFCPRGLCSPE	TRPS1	561	Q9UHF7
CSACQLKCHPSRGPF	TRIM67	231	Q6ZTA4
PVVILPCQHNLCRKC	TRIM55	36	Q9BYV6
PVKPSRLNVFCCPHC	ZFP57	291	Q9NU63
NCLQKITCPHCPRVF	RREB1	1241	Q92766
RKHPVLCLFCGAILC	UBR1	1621	Q8IWV7
DCCLQPLCHINPLCL	TENM4	856	Q6N022
PVTLPCNHTLCKPCF	RNF168	26	Q8IYW5
PCQKVICQEGHRCPL	ZNFX1	1321	Q9P2E3
HRFPEIDKPCGCNKC	ZNF229	231	Q9UJW7
CILHTGKKPFSCPEC	ZBTB24	481	O43167
LFKHSACPFRCPNCG	ZBTB1	526	Q9Y2K1
LPCQHTFCKPCLQRV	SH3RF2	26	Q8TEC5