Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionprotein kinase activity

EPHB4 ROCK2 INSR INSRR ELP1 YES1 CDC7 IGF1R LATS1 EPHA2 PRKCE PRKCI ULK1 FGR TAF1L ULK2 EIF2AK3 WNK2

8.10e-106009918GO:0004672
GeneOntologyMolecularFunctionphosphotransferase activity, alcohol group as acceptor

EPHB4 ROCK2 HYKK INSR INSRR ELP1 YES1 CDC7 IGF1R LATS1 EPHA2 PRKCE PRKCI ULK1 FGR TAF1L ULK2 EIF2AK3 WNK2

1.68e-097099919GO:0016773
GeneOntologyMolecularFunctionkinase activity

EPHB4 ROCK2 HYKK INSR INSRR ELP1 YES1 CDC7 IGF1R LATS1 EPHA2 PRKCE PRKCI ULK1 FGR TAF1L ULK2 EIF2AK3 WNK2

5.70e-097649919GO:0016301
GeneOntologyMolecularFunctiontransferase activity, transferring phosphorus-containing groups

EPHB4 ROCK2 HYKK POLE INSR INSRR ELP1 YES1 CDC7 IGF1R LATS1 EPHA2 PRKCE PRKCI ULK1 FGR TAF1L ULK2 EIF2AK3 WNK2

2.83e-089389920GO:0016772
GeneOntologyMolecularFunctioninsulin receptor activity

INSR INSRR IGF1R

1.18e-073993GO:0005009
GeneOntologyMolecularFunctionprotein tyrosine kinase activity

EPHB4 INSR INSRR YES1 IGF1R EPHA2 FGR

7.85e-06145997GO:0004713
GeneOntologyMolecularFunctiontransmembrane receptor protein tyrosine kinase activity

EPHB4 INSR INSRR IGF1R EPHA2

1.77e-0565995GO:0004714
GeneOntologyMolecularFunctionglutamate binding

GAD2 GRIK1 GRIN2B

4.14e-0514993GO:0016595
GeneOntologyMolecularFunctioninsulin receptor substrate binding

INSR INSRR IGF1R

5.15e-0515993GO:0043560
GeneOntologyMolecularFunctiontransmembrane receptor protein kinase activity

EPHB4 INSR INSRR IGF1R EPHA2

6.48e-0585995GO:0019199
GeneOntologyMolecularFunctionprotein serine/threonine kinase activity

ROCK2 CDC7 LATS1 PRKCE PRKCI ULK1 TAF1L ULK2 EIF2AK3 WNK2

7.39e-054469910GO:0004674
GeneOntologyMolecularFunctionprotein serine kinase activity

ROCK2 CDC7 LATS1 PRKCE PRKCI ULK1 ULK2 EIF2AK3 WNK2

8.06e-05363999GO:0106310
GeneOntologyMolecularFunctionminus-end-directed microtubule motor activity

DNAH10 DNAH7 DNAH14

9.14e-0518993GO:0008569
GeneOntologyMolecularFunctionprotein-hormone receptor activity

INSR INSRR IGF1R

1.70e-0422993GO:0016500
GeneOntologyMolecularFunctioncarboxylic acid binding

GAD2 UGT1A6 INSR GRIK1 GRIN2B GSTA3 PAM

1.88e-04239997GO:0031406
GeneOntologyMolecularFunctioninsulin binding

INSR IGF1R

2.41e-045992GO:0043559
GeneOntologyMolecularFunctionorganic acid binding

GAD2 UGT1A6 INSR GRIK1 GRIN2B GSTA3 PAM

2.73e-04254997GO:0043177
GeneOntologyMolecularFunctionglutamate receptor activity

GRID2 GRIK1 GRIN2B

3.17e-0427993GO:0008066
GeneOntologyMolecularFunctiondynein light intermediate chain binding

DNAH10 DNAH7 DNAH14

3.54e-0428993GO:0051959
GeneOntologyMolecularFunctionamino acid binding

GAD2 GRIK1 GRIN2B TAT

4.76e-0473994GO:0016597
GeneOntologyMolecularFunctionextracellularly glutamate-gated ion channel activity

GRIK1 GRIN2B

5.03e-047992GO:0005234
GeneOntologyMolecularFunctionglutamate-gated calcium ion channel activity

GRIK1 GRIN2B

6.68e-048992GO:0022849
GeneOntologyMolecularFunctioncarboxy-lyase activity

AMD1 GAD2 ECHDC1

7.50e-0436993GO:0016831
GeneOntologyMolecularFunctiondynein intermediate chain binding

DNAH10 DNAH7 DNAH14

8.13e-0437993GO:0045505
GeneOntologyMolecularFunctionphosphatidylinositol 3-kinase binding

INSR INSRR IGF1R

1.26e-0343993GO:0043548
GeneOntologyMolecularFunctioninsulin-like growth factor I binding

INSR IGF1R

1.83e-0313992GO:0031994
GeneOntologyMolecularFunctionHsp90 protein binding

UNC45A ULK1 EIF2AK3

2.57e-0355993GO:0051879
GeneOntologyMolecularFunctioncarbon-carbon lyase activity

AMD1 GAD2 ECHDC1

2.71e-0356993GO:0016830
GeneOntologyMolecularFunctiondiacylglycerol-dependent serine/threonine kinase activity

PRKCE PRKCI

2.79e-0316992GO:0004697
GeneOntologyMolecularFunctiontransmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential

GRID2 GRIK1 GRIN2B

2.85e-0357993GO:1904315
GeneOntologyMolecularFunctionglutamate-gated receptor activity

GRIK1 GRIN2B

3.15e-0317992GO:0004970
GeneOntologyMolecularFunctionneurotransmitter receptor activity involved in regulation of postsynaptic membrane potential

GRID2 GRIK1 GRIN2B

3.30e-0360993GO:0099529
GeneOntologyMolecularFunctioninsulin-like growth factor binding

INSR IGF1R

3.94e-0319992GO:0005520
GeneOntologyMolecularFunctionephrin receptor activity

EPHB4 EPHA2

3.94e-0319992GO:0005003
GeneOntologyMolecularFunctiontransmitter-gated channel activity

GRID2 GRIK1 GRIN2B

4.13e-0365993GO:0022835
GeneOntologyMolecularFunctiontransmitter-gated monoatomic ion channel activity

GRID2 GRIK1 GRIN2B

4.13e-0365993GO:0022824
GeneOntologyMolecularFunctionmicrotubule motor activity

DNAH10 DNAH7 DNAH14

5.09e-0370993GO:0003777
GeneOntologyBiologicalProcessprotein autophosphorylation

EPHB4 INSR INSRR IGF1R ULK1 FGR ULK2 EIF2AK3 WNK2

1.67e-062281009GO:0046777
GeneOntologyBiologicalProcessregulation of plasma membrane bounded cell projection organization

CARM1 TOX MCF2 GRID2 GRIN2B PLXND1 SYNGAP1 BMP7 IGF1R EPHA2 PALM PRKCI ULK1 CDH4 ULK2

1.35e-0584610015GO:0120035
GeneOntologyBiologicalProcessregulation of cell projection organization

CARM1 TOX MCF2 GRID2 GRIN2B PLXND1 SYNGAP1 BMP7 IGF1R EPHA2 PALM PRKCI ULK1 CDH4 ULK2

1.71e-0586310015GO:0031344
GeneOntologyBiologicalProcessnegative regulation of neurogenesis

PRTG MCF2 SYNGAP1 BMP7 ABCC8 ULK1 ULK2

2.15e-051731007GO:0050768
GeneOntologyBiologicalProcesssomatic sensory system development

ULK1 ULK2

2.33e-0521002GO:0160038
GeneOntologyBiologicalProcessnegative regulation of nervous system development

PRTG MCF2 SYNGAP1 BMP7 ABCC8 ULK1 ULK2

3.19e-051841007GO:0051961
GeneOntologyBiologicalProcessregulation of neuron projection development

CARM1 TOX MCF2 GRID2 PLXND1 SYNGAP1 BMP7 IGF1R PRKCI ULK1 CDH4 ULK2

4.07e-0561210012GO:0010975
GeneOntologyBiologicalProcessregulation of nervous system development

PRTG MCF2 GRID2 PLXND1 SYNGAP1 BMP7 ABCC8 PRKCI ULK1 CDH4 ULK2 EIF2AK3

4.98e-0562510012GO:0051960
GeneOntologyBiologicalProcessmale sex determination

INSR INSRR IGF1R

5.91e-05161003GO:0030238
GeneOntologyBiologicalProcessresponse to alkaline pH

ACER1 INSRR

6.96e-0531002GO:0010446
GeneOntologyBiologicalProcessresponse to pH

ACER1 INSRR ABCC8 PAM

9.32e-05491004GO:0009268
GeneOntologyBiologicalProcessresponse to nitrogen compound

CARM1 ROCK2 GAD2 INSR INSRR GRIN2B DDX1 STAT6 ATF6 BMP7 IGF1R FBP1 ABCC8 PALM PRKCE PRKCI EIF2AK3

1.23e-04127210017GO:1901698
GeneOntologyBiologicalProcesspeptidyl-serine phosphorylation

ROCK2 CDC7 LATS1 PRKCE PRKCI ULK1 ULK2 EIF2AK3

1.25e-043071008GO:0018105
GeneOntologyBiologicalProcessephrin receptor signaling pathway

EPHB4 ARHGEF28 YES1 EPHA2

1.37e-04541004GO:0048013
GeneOntologyBiologicalProcessresponse to hormone

CARM1 ROCK2 GAD2 UGT1A6 INSR INSRR STAT6 BMP7 IGF1R LATS1 FBP1 ABCC8 PRKCE PRKCI TAT

1.45e-04104210015GO:0009725
GeneOntologyBiologicalProcesspeptidyl-serine modification

ROCK2 CDC7 LATS1 PRKCE PRKCI ULK1 ULK2 EIF2AK3

1.63e-043191008GO:0018209
GeneOntologyBiologicalProcessexocrine system development

INSR PLXND1 BMP7 IGF1R

1.69e-04571004GO:0035272
GeneOntologyBiologicalProcesscell morphogenesis

ROCK2 PRTG ARHGEF28 MCF2 PLXND1 SYNGAP1 BMP7 IGF1R LATS1 EPHA2 CABP4 PALM ULK1 FGR CDH4 ULK2

1.94e-04119410016GO:0000902
GeneOntologyBiologicalProcessregulation of neurogenesis

PRTG MCF2 PLXND1 SYNGAP1 BMP7 ABCC8 PRKCI ULK1 CDH4 ULK2

2.00e-0451510010GO:0050767
GeneOntologyBiologicalProcessnegative regulation of axonogenesis

MCF2 SYNGAP1 ULK1 ULK2

2.34e-04621004GO:0050771
GeneOntologyBiologicalProcessimmune response-regulating cell surface receptor signaling pathway involved in phagocytosis

YES1 PRKCE FGR

2.35e-04251003GO:0002433
GeneOntologyBiologicalProcessFc-gamma receptor signaling pathway involved in phagocytosis

YES1 PRKCE FGR

2.35e-04251003GO:0038096
GeneOntologyBiologicalProcesscell junction organization

ROCK2 CABP1 INSR MDGA2 GRID2 GRIN2B PLXND1 SYNGAP1 IGF1R ABCC8 EPHA2 PALM PRKCI CDH4

2.50e-0497410014GO:0034330
GeneOntologyBiologicalProcesspeptidyl-amino acid modification

CARM1 ROCK2 SENP3 INSR YES1 CDC7 IGF1R LATS1 PRKCE PRKCI ULK1 FGR ULK2 EIF2AK3

2.56e-0497610014GO:0018193
GeneOntologyBiologicalProcesscell morphogenesis involved in neuron differentiation

ROCK2 PRTG ARHGEF28 MCF2 PLXND1 SYNGAP1 BMP7 IGF1R CABP4 ULK1 CDH4 ULK2

2.68e-0474810012GO:0048667
GeneOntologyBiologicalProcessresponse to abiotic stimulus

ROCK2 GAD2 ACER1 INSRR GRIN2B ABCB1 SYNGAP1 BMP7 IGF1R FBP1 ABCC8 CABP4 PALM PAM PRKCE EIF2AK3 NIPBL

2.76e-04136110017GO:0009628
GeneOntologyBiologicalProcesssmall GTPase-mediated signal transduction

ROCK2 ARHGEF28 MCF2 GRIN2B SYNGAP1 CELSR1 FBP1 HACE1 ULK1 SIPA1L2

2.84e-0453810010GO:0007264
GeneOntologyBiologicalProcessregulation of axonogenesis

MCF2 PLXND1 SYNGAP1 ULK1 CDH4 ULK2

3.47e-041921006GO:0050770
GeneOntologyBiologicalProcessglutamatergic neuron differentiation

GRID2 CABP4 ULK1

3.69e-04291003GO:1905962
GeneOntologyBiologicalProcessdendritic spine maintenance

INSR GRIN2B IGF1R

4.08e-04301003GO:0097062
GeneOntologyBiologicalProcessaxonogenesis

PRTG ARHGEF28 MCF2 PLXND1 SYNGAP1 BMP7 IGF1R ULK1 CDH4 ULK2

4.23e-0456610010GO:0007409
GeneOntologyBiologicalProcessneuron projection development

CARM1 ROCK2 PRTG ARHGEF28 TOX MCF2 GRID2 PLXND1 SYNGAP1 BMP7 IGF1R PALM PRKCI ULK1 CDH4 ULK2

4.41e-04128510016GO:0031175
GeneOntologyBiologicalProcesssex determination

INSR INSRR IGF1R

4.50e-04311003GO:0007530
GeneOntologyBiologicalProcessregulation of actin cytoskeleton organization

ROCK2 DNAI3 CELSR1 LATS1 PAM PRKCE FGR BAIAP2L2

5.63e-043841008GO:0032956
GeneOntologyBiologicalProcessneuron development

CARM1 ROCK2 PRTG ARHGEF28 TOX MCF2 GRID2 PLXND1 SYNGAP1 BMP7 IGF1R CABP4 PALM PRKCI ULK1 CDH4 ULK2

6.33e-04146310017GO:0048666
GeneOntologyBiologicalProcessFc receptor mediated stimulatory signaling pathway

YES1 PRKCE FGR

6.47e-04351003GO:0002431
GeneOntologyCellularComponentinsulin receptor complex

INSR INSRR IGF1R

4.11e-074993GO:0005899
GeneOntologyCellularComponentinner dynein arm

DNAH10 DNAI3 DNAH7

1.21e-0510993GO:0036156
GeneOntologyCellularComponentdynein complex

DNAH10 DNAI3 DNAH7 DNAH14

1.25e-0454994GO:0030286
GeneOntologyCellularComponentglutamatergic synapse

ROCK2 CABP1 MDGA2 GRID2 GRIK1 GRIN2B PLXND1 YES1 SYNGAP1 IGF1R PRKCE PRKCI SIPA1L2

1.25e-048179913GO:0098978
GeneOntologyCellularComponentpostsynaptic specialization, intracellular component

CABP1 GRIN2B YES1 SYNGAP1

1.44e-0456994GO:0099091
GeneOntologyCellularComponentaxonemal dynein complex

DNAH10 DNAI3 DNAH7

2.20e-0425993GO:0005858
GeneOntologyCellularComponentaxon

CABP1 GAD2 PRTG INSR INSRR GRIK1 GRIN2B PLXND1 IGF1R CABP4 PALM ULK1

1.02e-038919912GO:0030424
GeneOntologyCellularComponenttransferase complex, transferring phosphorus-containing groups

POLE INSR INSRR IGF1R PRKCI ULK1 TAF1L

1.08e-03335997GO:0061695
GeneOntologyCellularComponentionotropic glutamate receptor complex

GRID2 GRIK1 GRIN2B

1.27e-0345993GO:0008328
GeneOntologyCellularComponentprotein kinase complex

INSR INSRR IGF1R PRKCI ULK1

1.30e-03170995GO:1902911
GeneOntologyCellularComponentpostsynaptic density, intracellular component

CABP1 GRIN2B SYNGAP1

1.62e-0349993GO:0099092
GeneOntologyCellularComponentneurotransmitter receptor complex

GRID2 GRIK1 GRIN2B

1.72e-0350993GO:0098878
GeneOntologyCellularComponentreceptor complex

EPHB4 INSR INSRR GRID2 GRIK1 GRIN2B PLXND1 IGF1R EPHA2

1.75e-03581999GO:0043235
GeneOntologyCellularComponentsomatodendritic compartment

PCSK5 CABP1 GAD2 ACAD9 INSR TMPRSS5 GRID2 GRIK1 GRIN2B SYNGAP1 IGF1R PALM PAM ULK1

1.91e-0312289914GO:0036477
DomainPROTEIN_KINASE_ATP

EPHB4 ROCK2 INSR INSRR YES1 CDC7 IGF1R LATS1 EPHA2 PRKCE PRKCI ULK1 FGR ULK2 EIF2AK3 WNK2

2.77e-0945910016PS00107
DomainKinase-like_dom

EPHB4 ROCK2 HYKK INSR INSRR YES1 CDC7 IGF1R LATS1 EPHA2 PRKCE PRKCI ULK1 FGR ULK2 EIF2AK3 WNK2

4.10e-0954210017IPR011009
DomainProt_kinase_dom

EPHB4 ROCK2 INSR INSRR YES1 CDC7 IGF1R LATS1 EPHA2 PRKCE PRKCI ULK1 FGR ULK2 EIF2AK3 WNK2

6.80e-0948910016IPR000719
DomainPROTEIN_KINASE_DOM

EPHB4 ROCK2 INSR INSRR YES1 CDC7 IGF1R LATS1 EPHA2 PRKCE PRKCI ULK1 FGR ULK2 EIF2AK3 WNK2

7.63e-0949310016PS50011
DomainProtein_kinase_ATP_BS

EPHB4 ROCK2 INSR INSRR YES1 CDC7 IGF1R EPHA2 PRKCE PRKCI ULK1 FGR ULK2 EIF2AK3

1.44e-0837910014IPR017441
DomainTyr_kinase_insulin-like_rcpt

INSR INSRR IGF1R

1.49e-0731003IPR016246
DomainTyrKc

EPHB4 INSR INSRR YES1 IGF1R EPHA2 FGR

4.54e-07881007SM00219
DomainTyr_kinase_cat_dom

EPHB4 INSR INSRR YES1 IGF1R EPHA2 FGR

4.54e-07881007IPR020635
DomainPROTEIN_KINASE_TYR

EPHB4 INSR INSRR YES1 IGF1R EPHA2 FGR

8.84e-07971007PS00109
DomainTyr_kinase_AS

EPHB4 INSR INSRR YES1 IGF1R EPHA2 FGR

8.84e-07971007IPR008266
DomainFurin_repeat

PCSK5 INSR INSRR IGF1R

2.23e-06181004IPR006212
DomainFU

PCSK5 INSR INSRR IGF1R

2.23e-06181004SM00261
DomainFurin-like

INSR INSRR IGF1R

5.13e-0671003PF00757
DomainRcpt_L-dom

INSR INSRR IGF1R

5.13e-0671003IPR000494
DomainFurin-like_Cys-rich_dom

INSR INSRR IGF1R

5.13e-0671003IPR006211
DomainRecep_L_domain

INSR INSRR IGF1R

5.13e-0671003PF01030
Domain-

INSR INSRR IGF1R

5.13e-06710033.80.20.20
DomainPkinase_Tyr

EPHB4 INSR INSRR YES1 IGF1R EPHA2 FGR

5.98e-061291007PF07714
DomainSer-Thr/Tyr_kinase_cat_dom

EPHB4 INSR INSRR YES1 IGF1R EPHA2 FGR

9.32e-061381007IPR001245
DomainGrowth_fac_rcpt_

EPHB4 PCSK5 INSR INSRR CELSR1 IGF1R EPHA2

2.07e-051561007IPR009030
DomainTyr_kinase_rcpt_2_CS

INSR INSRR IGF1R

2.38e-05111003IPR002011
DomainSer/Thr_kinase_C

ULK1 ULK2

2.84e-0521002IPR022708
DomainDUF3543

ULK1 ULK2

2.84e-0521002PF12063
DomainFGR

YES1 FGR

2.84e-0521002IPR028459
DomainSer/Thr_kin_STPK_Ulk-1/2

ULK1 ULK2

2.84e-0521002IPR016237
DomainRECEPTOR_TYR_KIN_II

INSR INSRR IGF1R

3.16e-05121003PS00239
DomainPkinase_C

ROCK2 LATS1 PRKCE PRKCI

4.46e-05371004IPR017892
DomainDynein_heavy_chain_D4_dom

DNAH10 DNAH7 DNAH14

5.19e-05141003IPR024317
DomainDynein_HC_stalk

DNAH10 DNAH7 DNAH14

5.19e-05141003IPR024743
DomainMT

DNAH10 DNAH7 DNAH14

5.19e-05141003PF12777
DomainAAA_8

DNAH10 DNAH7 DNAH14

5.19e-05141003PF12780
DomainDHC_fam

DNAH10 DNAH7 DNAH14

6.47e-05151003IPR026983
DomainDynein_heavy_dom

DNAH10 DNAH7 DNAH14

6.47e-05151003IPR004273
DomainDynein_heavy

DNAH10 DNAH7 DNAH14

6.47e-05151003PF03028
DomainPkinase_C

ROCK2 LATS1 PRKCE PRKCI

7.41e-05421004PF00433
DomainFN3

EPHB4 PRTG INSR INSRR MDGA2 IGF1R EPHA2

9.73e-051991007PS50853
DomainIontro_rcpt

GRID2 GRIK1 GRIN2B

1.15e-04181003IPR001320
DomainLig_chan-Glu_bd

GRID2 GRIK1 GRIN2B

1.15e-04181003PF10613
DomainIono_rcpt_met

GRID2 GRIK1 GRIN2B

1.15e-04181003IPR001508
DomainGlu/Gly-bd

GRID2 GRIK1 GRIN2B

1.15e-04181003IPR019594
DomainLig_chan-Glu_bd

GRID2 GRIK1 GRIN2B

1.15e-04181003SM00918
DomainLig_chan

GRID2 GRIK1 GRIN2B

1.15e-04181003PF00060
DomainPBPe

GRID2 GRIK1 GRIN2B

1.15e-04181003SM00079
DomainSer/Thr_kinase_AS

ROCK2 CDC7 LATS1 PRKCE PRKCI ULK1 ULK2 EIF2AK3 WNK2

1.27e-043571009IPR008271
DomainFN3_dom

EPHB4 PRTG INSR INSRR MDGA2 IGF1R EPHA2

1.32e-042091007IPR003961
DomainS_TKc

ROCK2 CDC7 LATS1 PRKCE PRKCI ULK1 ULK2 EIF2AK3 WNK2

1.32e-043591009SM00220
DomainPROTEIN_KINASE_ST

ROCK2 CDC7 LATS1 PRKCE PRKCI ULK1 ULK2 EIF2AK3 WNK2

1.41e-043621009PS00108
DomainCa-bd_2

CABP1 CABP4

1.69e-0441002IPR015754
DomainPkinase

ROCK2 CDC7 LATS1 PRKCE PRKCI ULK1 ULK2 EIF2AK3 WNK2

2.07e-043811009PF00069
DomainAGC-kinase_C

ROCK2 LATS1 PRKCE PRKCI

2.30e-04561004IPR000961
DomainAGC_KINASE_CTER

ROCK2 LATS1 PRKCE PRKCI

2.30e-04561004PS51285
DomainS_TK_X

ROCK2 LATS1 PRKCE PRKCI

2.30e-04561004SM00133
Domainfn3

EPHB4 PRTG INSR INSRR IGF1R EPHA2

2.36e-041621006PF00041
DomainC1_1

ROCK2 ARHGEF28 PRKCE PRKCI

2.46e-04571004PF00130
DomainEphrin_rec_like

EPHB4 PCSK5 EPHA2

3.14e-04251003SM01411
DomainTyr-kin_ephrin_A/B_rcpt-like

EPHB4 PCSK5 EPHA2

3.14e-04251003IPR011641
DomainZF_DAG_PE_1

ROCK2 ARHGEF28 PRKCE PRKCI

3.84e-04641004PS00479
DomainZF_DAG_PE_2

ROCK2 ARHGEF28 PRKCE PRKCI

3.84e-04641004PS50081
DomainC1

ROCK2 ARHGEF28 PRKCE PRKCI

4.08e-04651004SM00109
DomainPE/DAG-bd

ROCK2 ARHGEF28 PRKCE PRKCI

4.32e-04661004IPR002219
DomainFN3

EPHB4 PRTG INSR INSRR IGF1R EPHA2

4.80e-041851006SM00060
DomainANF_lig-bd_rcpt

GRID2 GRIK1 GRIN2B

1.01e-03371003IPR001828
DomainANF_receptor

GRID2 GRIK1 GRIN2B

1.01e-03371003PF01094
DomainPeripla_BP_I

GRID2 GRIK1 GRIN2B

1.18e-03391003IPR028082
DomainRECEPTOR_TYR_KIN_V_2

EPHB4 EPHA2

2.48e-03141002PS00791
DomainRECEPTOR_TYR_KIN_V_1

EPHB4 EPHA2

2.48e-03141002PS00790
DomainEph_TM

EPHB4 EPHA2

2.48e-03141002IPR027936
DomainTyr_kinase_rcpt_V_CS

EPHB4 EPHA2

2.48e-03141002IPR001426
DomainEPH_lbd

EPHB4 EPHA2

2.48e-03141002SM00615
DomainDynein_heavy_dom-2

DNAH10 DNAH7

2.48e-03141002IPR013602
DomainDHC_N2

DNAH10 DNAH7

2.48e-03141002PF08393
DomainEphrin_lbd

EPHB4 EPHA2

2.48e-03141002PF01404
DomainEphA2_TM

EPHB4 EPHA2

2.48e-03141002PF14575
DomainTyr_kinase_ephrin_rcpt

EPHB4 EPHA2

2.48e-03141002IPR016257
DomainEphrin_rcpt_lig-bd_dom

EPHB4 EPHA2

2.48e-03141002IPR001090
DomainEPH_LBD

EPHB4 EPHA2

2.48e-03141002PS51550
PathwayWP_HIPPO_SIGNALING_REGULATION

INSR IGF1R LATS1 EPHA2 PRKCE PRKCI CDH4

1.02e-0698777M39830
PathwayREACTOME_EPHB_MEDIATED_FORWARD_SIGNALING

EPHB4 ROCK2 ARHGEF28 GRIN2B YES1

3.10e-0642775M27308
PathwayREACTOME_EPH_EPHRIN_SIGNALING

EPHB4 ROCK2 ARHGEF28 GRIN2B YES1 EPHA2

1.07e-0592776M27201
PathwayREACTOME_EPH_EPHRIN_SIGNALING

EPHB4 ROCK2 ARHGEF28 YES1 EPHA2

2.73e-0565775MM14911
PathwayREACTOME_EPHB_MEDIATED_FORWARD_SIGNALING

EPHB4 ROCK2 ARHGEF28 YES1

4.74e-0537774MM15022
PathwayWP_NANOPARTICLE_TRIGGERED_AUTOPHAGIC_CELL_DEATH

INSR ULK1 ULK2

2.57e-0423773M39325
Pubmed

Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers.

CARM1 EPHB4 PCSK5 CABP1 DNAH10 INSR PLXND1 YES1 CES2 IGF1R LATS1 CABP4 PRKCE PRKCI ULK1 FGR TAF1L ULK2 WNK2

2.82e-137301001934857952
Pubmed

A Multipronged Unbiased Strategy Guides the Development of an Anti-EGFR/EPHA2-Bispecific Antibody for Combination Cancer Therapy.

ROCK2 INSR YES1 AKAP8L IARS2 IGF1R EPHA2 PALM STEAP3 PRKCI MICAL3 SIPA1L2

3.41e-094211001236976175
Pubmed

The protein tyrosine kinase family of the human genome.

EPHB4 INSR INSRR YES1 IGF1R EPHA2 FGR

4.56e-0983100711114734
Pubmed

Sexually dimorphic behavior, neuronal activity, and gene expression in Chd8-mutant mice.

AMD1 GAD2 GRIN2B SYNGAP1 STXBP2 BAIAP2L2

1.40e-0856100630104731
Pubmed

Insulin receptor-related receptor as an extracellular alkali sensor.

INSR INSRR IGF1R

2.31e-083100321641549
Pubmed

Insulin receptor-related (Irr) is expressed in pre-implantation embryos: a possible relationship to "growth factor Y" and sex determination.

INSR INSRR IGF1R

2.31e-083100321681845
Pubmed

Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.

EPHB4 ACAD9 POLE ELP1 UNC45A YES1 NSDHL ATF6 IARS2 SEC24C PMPCA EPHA2 PALM STEAP3 PRKCI SIPA1L2 EIF2AK3 DCAF7

2.25e-0714871001833957083
Pubmed

The phosphotyrosine interactome of the insulin receptor family and its substrates IRS-1 and IRS-2.

INSR INSRR IGF1R

2.30e-075100319001411
Pubmed

Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.

PCSK5 ARHGEF28 POLE SENP3 ELP1 AKAP8L DDX1 PAM PRKCI MICAL3 ULK1 HPS5

3.86e-076501001238777146
Pubmed

Role of Unc51.1 and its binding partners in CNS axon outgrowth.

SYNGAP1 ULK1 ULK2

4.58e-076100315014045
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

EPHB4 PCSK5 POLE PLXND1 CELSR1 IGF1R PALM STEAP3 MICAL3 ULK1 SIPA1L2 ULK2 ABTB2 TEX19 WNK2

6.28e-0711051001535748872
Pubmed

Identification of tyrosine kinases expressed in the male mouse gubernaculum during development.

EPHB4 INSR IGF1R EPHA2

7.77e-0725100415254900
Pubmed

Comparative analysis of the signaling capabilities of the insulin receptor-related receptor.

INSR INSRR IGF1R

1.28e-068100315629149
Pubmed

Targeting promiscuous heterodimerization overcomes innate resistance to ERBB2 dimerization inhibitors in breast cancer.

INSR INSRR IGF1R EPHA2

5.43e-0640100430898150
Pubmed

KAP1 facilitates reinstatement of heterochromatin after DNA replication.

CARM1 POLE ECHDC1 ELP1 YES1 NSDHL IARS2 STXBP2 SEC24C PRKCI NIPBL

5.99e-067041001129955894
Pubmed

Testis determination requires insulin receptor family function in mice.

INSR INSRR IGF1R

6.46e-0613100314628051
Pubmed

Glutamatergic gene variants impact the clinical profile of efficacy and side effects of haloperidol.

GRID2 GRIK1 GRIN2B

6.46e-0613100320859245
Pubmed

Heterodimerization of glycosylated insulin-like growth factor-1 receptors and insulin receptors in cancer cells sensitive to anti-IGF1R antibody.

INSR IGF1R

8.18e-062100222438913
Pubmed

Conservation of structure, function and inhibitor binding in UNC-51-like kinase 1 and 2 (ULK1/2).

ULK1 ULK2

8.18e-062100230782972
Pubmed

Insulin and IGF-1 have both overlapping and distinct effects on CD4+ T cell mitochondria, metabolism, and function.

INSR IGF1R

8.18e-062100238383709
Pubmed

Oncogenic functions of IGF1R and INSR in prostate cancer include enhanced tumor growth, cell migration and angiogenesis.

INSR IGF1R

8.18e-062100224809298
Pubmed

A kinase-independent role for unoccupied insulin and IGF-1 receptors in the control of apoptosis.

INSR IGF1R

8.18e-062100221139139
Pubmed

The insulin and IGF1 receptor kinase domains are functional dimers in the activated state.

INSR IGF1R

8.18e-062100225758790
Pubmed

Non-Structural Protein 2B of Human Rhinovirus 16 Activates Both PERK and ATF6 Rather Than IRE1 to Trigger ER Stress.

ATF6 EIF2AK3

8.18e-062100230717233
Pubmed

Coexpression of insulin receptor-related receptor and insulin-like growth factor 1 receptor correlates with enhanced apoptosis and dedifferentiation in human neuroblastomas.

INSRR IGF1R

8.18e-062100214654552
Pubmed

Compounds from the marine sponge Cribrochalina vasculum offer a way to target IGF-1R mediated signaling in tumor cells.

INSR IGF1R

8.18e-062100227384680
Pubmed

Spermidine overrides INSR (insulin receptor)-IGF1R (insulin-like growth factor 1 receptor)-mediated inhibition of autophagy in the aging heart.

INSR IGF1R

8.18e-062100235786404
Pubmed

Insulin-Mediated Signaling Facilitates Resistance to PDGFR Inhibition in Proneural hPDGFB-Driven Gliomas.

INSR IGF1R

8.18e-062100228138037
Pubmed

Distinct functions of Ulk1 and Ulk2 in the regulation of lipid metabolism in adipocytes.

ULK1 ULK2

8.18e-062100224135897
Pubmed

Thyrocyte-specific deletion of insulin and IGF-1 receptors induces papillary thyroid carcinoma-like lesions through EGFR pathway activation.

INSR IGF1R

8.18e-062100230070361
Pubmed

Ca2+-binding proteins tune Ca2+-feedback to Cav1.3 channels in mouse auditory hair cells.

CABP1 CABP4

8.18e-062100217947313
Pubmed

A synaptic Ras-GTPase activating protein (p135 SynGAP) inhibited by CaM kinase II.

GRIN2B SYNGAP1

8.18e-06210029620694
Pubmed

Homozygous receptors for insulin and not IGF-1 accelerate intimal hyperplasia in insulin resistance and diabetes.

INSR IGF1R

8.18e-062100231562314
Pubmed

Preserved pancreatic beta-cell development and function in mice lacking the insulin receptor-related receptor.

INSR INSRR

8.18e-062100211463843
Pubmed

Insulin-like growth factor I receptors are more abundant than insulin receptors in human micro- and macrovascular endothelial cells.

INSR IGF1R

8.18e-062100214722023
Pubmed

Insulin receptors in beta-cells are critical for islet compensatory growth response to insulin resistance.

INSR IGF1R

8.18e-062100217416680
Pubmed

Coxsackievirus infection induces a non-canonical autophagy independent of the ULK and PI3K complexes.

ULK1 ULK2

8.18e-062100233149253
Pubmed

Impaired thermogenesis and adipose tissue development in mice with fat-specific disruption of insulin and IGF-1 signalling.

INSR IGF1R

8.18e-062100222692545
Pubmed

High IGF-IR activity in triple-negative breast cancer cell lines and tumorgrafts correlates with sensitivity to anti-IGF-IR therapy.

INSR IGF1R

8.18e-062100221177763
Pubmed

ULK1/2 Constitute a Bifurcate Node Controlling Glucose Metabolic Fluxes in Addition to Autophagy.

ULK1 ULK2

8.18e-062100227153534
Pubmed

Evaluation of EphA2 and EphB4 as Targets for Image-Guided Colorectal Cancer Surgery.

EPHB4 EPHA2

8.18e-062100228165374
Pubmed

Changes in insulin and IGF-I receptor expression during differentiation of human preadipocytes.

INSR IGF1R

8.18e-062100218693051
Pubmed

Insulin/IGF-1 hybrid receptor expression on human platelets: consequences for the effect of insulin on platelet function.

INSR IGF1R

8.18e-062100219817984
Pubmed

Interaction of myocardial insulin receptor and IGF receptor signaling in exercise-induced cardiac hypertrophy.

INSR IGF1R

8.18e-062100219744489
Pubmed

Adipocyte Dynamics and Reversible Metabolic Syndrome in Mice with an Inducible Adipocyte-Specific Deletion of the Insulin Receptor.

INSR IGF1R

8.18e-062100228065828
Pubmed

Insulin signaling in the hippocampus and amygdala regulates metabolism and neurobehavior.

INSR IGF1R

8.18e-062100230765523
Pubmed

Functional collaboration of insulin-like growth factor-1 receptor (IGF-1R), but not insulin receptor (IR), with acute GH signaling in mouse calvarial cells.

INSR IGF1R

8.18e-062100224302626
Pubmed

Novel nuclear localization and potential function of insulin-like growth factor-1 receptor/insulin receptor hybrid in corneal epithelial cells.

INSR IGF1R

8.18e-062100222879999
Pubmed

Leucine-973 is a crucial residue differentiating insulin and IGF-1 receptor signaling.

INSR IGF1R

8.18e-062100236548088
Pubmed

Essential role of insulin and insulin-like growth factor 1 receptor signaling in cardiac development and function.

INSR IGF1R

8.18e-062100217189427
Pubmed

[Effects of insulin on expression of insulin receptor and insulin-like growth factor-1 receptor and proliferation in Reh cells].

INSR IGF1R

8.18e-062100222541124
Pubmed

A functional assessment of insulin/insulin-like growth factor-I hybrid receptors.

INSR IGF1R

8.18e-06210027895674
Pubmed

Insulin receptor and IGF1R are not required for oocyte growth, differentiation, and maturation in mice.

INSR IGF1R

8.18e-062100219851056
Pubmed

Regulation of nutrient-sensitive autophagy by uncoordinated 51-like kinases 1 and 2.

ULK1 ULK2

8.18e-062100223291478
Pubmed

Combined and individual tumor-specific expression of insulin-like growth factor-I receptor, insulin receptor and phospho-insulin-like growth factor-I receptor/insulin receptor in primary breast cancer: Implications for prognosis in different treatment groups.

INSR IGF1R

8.18e-062100228030849
Pubmed

PKCλ/ι inhibition activates an ULK2-mediated interferon response to repress tumorigenesis.

PRKCI ULK2

8.18e-062100234560002
Pubmed

Insulin-like growth factor type 1 receptor and insulin receptor isoform expression and signaling in mammary epithelial cells.

INSR IGF1R

8.18e-062100219406949
Pubmed

Expression of insulin receptor (IR) A and B isoforms, IGF-IR, and IR/IGF-IR hybrid receptors in vascular smooth muscle cells and their role in cell migration in atherosclerosis.

INSR IGF1R

8.18e-062100227905925
Pubmed

Glutamate Attenuates the Survival Property of IGFR through NR2B Containing N-Methyl-D-aspartate Receptors in Cortical Neurons.

GRIN2B IGF1R

8.18e-062100232849999
Pubmed

Placental glycogen stores are increased in mice with H19 null mutations but not in those with insulin or IGF type 1 receptor mutations.

INSR IGF1R

8.18e-062100219524295
Pubmed

Epidermal insulin/IGF-1 signalling control interfollicular morphogenesis and proliferative potential through Rac activation.

INSR IGF1R

8.18e-062100218650937
Pubmed

Ulk1, Not Ulk2, Is Required for Exercise Training-Induced Improvement of Insulin Response in Skeletal Muscle.

ULK1 ULK2

8.18e-062100234658916
Pubmed

A versatile insulin analog with high potency for both insulin and insulin-like growth factor 1 receptors: Structural implications for receptor binding.

INSR IGF1R

8.18e-062100230213860
Pubmed

Epithelial-mesenchymal transition predicts sensitivity to the dual IGF-1R/IR inhibitor OSI-906 in hepatocellular carcinoma cell lines.

INSR IGF1R

8.18e-062100222161861
Pubmed

Male Brown Fat-Specific Double Knockout of IGFIR/IR: Atrophy, Mitochondrial Fission Failure, Impaired Thermogenesis, and Obesity.

INSR IGF1R

8.18e-062100229040448
Pubmed

Scleral PERK and ATF6 as targets of myopic axial elongation of mouse eyes.

ATF6 EIF2AK3

8.18e-062100236216837
Pubmed

A novel approach to identify two distinct receptor binding surfaces of insulin-like growth factor II.

INSR IGF1R

8.18e-062100219139090
Pubmed

Characterization of a hybrid receptor formed by dimerization of the insulin receptor-related receptor (IRR) with the insulin receptor (IR): coexpression of cDNAs encoding human IRR and human IR in NIH-3T3 cells.

INSR INSRR

8.18e-06210028916919
Pubmed

Apolipoprotein C3 and circulating mediators of preadipocyte proliferation in states of lipodystrophy.

INSR IGF1R

8.18e-062100235964946
Pubmed

Knockout of insulin and IGF-1 receptors on vascular endothelial cells protects against retinal neovascularization.

INSR IGF1R

8.18e-062100212813019
Pubmed

Epigenetic DNA methylation in the promoters of the Igf1 receptor and insulin receptor genes in db/db mice.

INSR IGF1R

8.18e-062100221474992
Pubmed

Endothelial Cell Mediated Promotion of Ciliated Cell Differentiation of Human Airway Basal Cells via Insulin and Insulin-Like Growth Factor 1 Receptor Mediated Signaling.

INSR IGF1R

8.18e-062100228050756
Pubmed

Total insulin and IGF-I resistance in pancreatic beta cells causes overt diabetes.

INSR IGF1R

8.18e-062100216642022
Pubmed

IGF1R Expression in Ovarian Granulosa Cells Is Essential for Steroidogenesis, Follicle Survival, and Fertility in Female Mice.

INSR IGF1R

8.18e-062100228407051
Pubmed

Requirement of atypical protein kinase clambda for insulin stimulation of glucose uptake but not for Akt activation in 3T3-L1 adipocytes.

INSR PRKCI

8.18e-06210029819385
Pubmed

BI 885578, a Novel IGF1R/INSR Tyrosine Kinase Inhibitor with Pharmacokinetic Properties That Dissociate Antitumor Efficacy and Perturbation of Glucose Homeostasis.

INSR IGF1R

8.18e-062100226438154
Pubmed

Insulin and IGF-I inhibit GH synthesis and release in vitro and in vivo by separate mechanisms.

INSR IGF1R

8.18e-062100223671263
Pubmed

Suppression of Cardiac Autophagy by Hyperinsulinemia in Insulin Receptor-Deficient Hearts Is Mediated by Insulin-Like Growth Factor Receptor Signaling.

INSR IGF1R

8.18e-062100231088290
Pubmed

Development of a Quantitative PCR Assay for Detection of Human Insulin-Like Growth Factor Receptor and Insulin Receptor Isoforms.

INSR IGF1R

8.18e-062100226862994
Pubmed

Human microvascular endothelial cells are sensitive to IGF-I but resistant to insulin at the receptor level.

INSR IGF1R

8.18e-062100218708119
Pubmed

Role of insulin receptor in the regulation of glucose uptake in neonatal hepatocytes.

INSR IGF1R

8.18e-062100216644916
Pubmed

The signaling potential of the receptors for insulin and insulin-like growth factor I (IGF-I) in 3T3-L1 adipocytes: comparison of glucose transport activity, induction of oncogene c-fos, glucose transporter mRNA, and DNA-synthesis.

INSR IGF1R

8.18e-06210021660482
Pubmed

Insulin and insulin-like growth factor 1 receptors are required for normal expression of imprinted genes.

INSR IGF1R

8.18e-062100225246545
Pubmed

Interneuronal GluK1 kainate receptors control maturation of GABAergic transmission and network synchrony in the hippocampus.

GAD2 GRIK1

8.18e-062100237210550
Pubmed

Identification of mouse ULK1, a novel protein kinase structurally related to C. elegans UNC-51.

ULK1 ULK2

8.18e-06210029600096
Pubmed

Lipodystrophy Due to Adipose Tissue-Specific Insulin Receptor Knockout Results in Progressive NAFLD.

INSR IGF1R

8.18e-062100227207510
Pubmed

Differential Roles of Insulin and IGF-1 Receptors in Adipose Tissue Development and Function.

INSR IGF1R

8.18e-062100227207537
Pubmed

Reduced insulin-like growth factor I receptor and altered insulin receptor isoform mRNAs in normal mucosa predict colorectal adenoma risk.

INSR IGF1R

8.18e-062100225017244
Pubmed

PKCε inhibits isolation and stemness of side population cells via the suppression of ABCB1 transporter and PI3K/Akt, MAPK/ERK signaling in renal cell carcinoma cell line 769P.

ABCB1 PRKCE

8.18e-062100227037060
Pubmed

Differential expression of IGF-I and insulin receptor isoforms in HPV positive and negative human cervical cancer cell lines.

INSR IGF1R

8.18e-062100218711691
Pubmed

The requirement of uncoordinated 51-like kinase 1 (ULK1) and ULK2 in the regulation of autophagy.

ULK1 ULK2

8.18e-062100221460635
Pubmed

Differential Expression of IR-A, IR-B and IGF-1R in Endometrial Physiology and Distinct Signature in Adenocarcinoma.

INSR IGF1R

8.18e-062100227088794
Pubmed

Decreased insulin-like growth factor I-mediated protein tyrosine phosphorylation in human olivopontocerebellar atrophy and lurcher mutant mouse.

GRID2 IGF1R

8.18e-06210027931420
Pubmed

Preclinical and first-in-human phase I studies of KW-2450, an oral tyrosine kinase inhibitor with insulin-like growth factor receptor-1/insulin receptor selectivity.

INSR IGF1R

8.18e-062100226850678
Pubmed

Insulin, insulin receptor and insulin-like growth factor-I receptor on the human ocular surface.

INSR IGF1R

8.18e-062100212613967
Pubmed

Signalling through the insulin receptor and the insulin-like growth factor-I receptor.

INSR IGF1R

8.18e-06210027821728
Pubmed

A kinome-wide screen identifies the insulin/IGF-I receptor pathway as a mechanism of escape from hormone dependence in breast cancer.

INSR IGF1R

8.18e-062100221908557
Pubmed

Distinct roles of activating transcription factor 6 (ATF6) and double-stranded RNA-activated protein kinase-like endoplasmic reticulum kinase (PERK) in transcription during the mammalian unfolded protein response.

ATF6 EIF2AK3

8.18e-062100212014989
Pubmed

Obesity and intestinal epithelial deletion of the insulin receptor, but not the IGF 1 receptor, affect radiation-induced apoptosis in colon.

INSR IGF1R

8.18e-062100226251471
Pubmed

Differential Role of Insulin/IGF-1 Receptor Signaling in Muscle Growth and Glucose Homeostasis.

INSR IGF1R

8.18e-062100225981038
InteractionGJA1 interactions

ROCK2 INSR YES1 NSDHL IARS2 IGF1R STXBP2 EPHA2 PALM STEAP3 PRKCE ULK1 SIPA1L2 EIF2AK3

8.60e-075839814int:GJA1
InteractionDUSP26 interactions

POLE IGF1R PMPCA EPHA2 ABTB2

9.98e-0659985int:DUSP26
InteractionCDC37 interactions

EPHB4 INSR INSRR BIRC3 UNC45A YES1 IGF1R LATS1 EPHA2 PRKCE PRKCI ULK1 FGR

1.45e-056459813int:CDC37
Cytoband12q24.3

POLE ULK1

7.01e-056100212q24.3
Cytoband2p24

ROCK2 DDX1

3.06e-041210022p24
Cytoband9q22.3

FBP1 WNK2

3.06e-041210029q22.3
Cytoband19p13.3-p13.2

INSR STXBP2

4.20e-0414100219p13.3-p13.2
CytobandEnsembl 112 genes in cytogenetic band chr19p13

CARM1 ACER1 INSR AKAP8L STXBP2 GET3 PALM

1.84e-037971007chr19p13
Cytoband15q21.3

PRTG MINDY2

2.67e-0335100215q21.3
GeneFamilyDyneins, axonemal

DNAH10 DNAH7 DNAH14

3.96e-0517723536
GeneFamilyFibronectin type III domain containing

EPHB4 PRTG INSR INSRR IGF1R EPHA2

4.22e-05160726555
GeneFamilyReceptor Tyrosine Kinases|CD molecules

INSR INSRR IGF1R

5.38e-0440723321
GeneFamilyMaestro heat like repeat containing

MROH2A MRO

8.40e-0411722636
GeneFamilyFibronectin type III domain containing|Sterile alpha motif domain containing|EPH receptors

EPHB4 EPHA2

1.38e-03147221095
GeneFamilyAutophagy related

ULK1 ULK2

7.62e-03337221022
GeneFamilySH2 domain containing

YES1 STAT6 FGR

7.64e-03101723741
ToppCellfacs-Lung-24m-Endothelial-capillary_endothelial-capillary_endothelial_cell-capillary_type_1_endothelial_cell|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

PRTG DNAH10 POLE MDGA2 GRIN2B PKHD1L1 TEX19 WNK2

3.34e-091621008bf886e22ff2a20353499004b53f25fb9e6574896
ToppCellfacs-Lung-Endomucin-24m-Endothelial-Capillary_Type_1_Cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PRTG POLE MDGA2 GRIN2B TEX19 WNK2

9.38e-07145100696712c68ab759d7ade0d912581a1a7c25dc6def8
ToppCellCOVID-19-kidney-Technical/muscle_(Mes)|COVID-19 / Disease (COVID-19 only), tissue and cell type

WDR64 MDGA2 GRID2 GRIN2B SLC35F4 CDH4

1.06e-061481006d6ac5972267254651dfbe16bb4e9a62228093cc7
ToppCellCOVID-19-kidney-Epi_(Mes)|COVID-19 / Disease (COVID-19 only), tissue and cell type

ARHGEF28 MDGA2 DNAH7 SLC35F4 BMP7 MICAL3

3.09e-061781006544379f5a6145429762258d426b876bb36c112f5
ToppCell(05)_Ciliated-(4)_1wkpi|(05)_Ciliated / shred by cell type and Timepoint

ARHGEF28 DNAH10 STXBP2 PAM TTC39A TMC5

3.29e-06180100685fc9b164147b28545e2397d32302eea03ef6346
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L3-5_SST_MAFB|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PCSK5 GAD2 PRTG GRID2 GRIK1 ABTB2

5.06e-06194100683863da11dfbe59b2d0a2c08db40b537c150588c
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

ARHGEF28 DNAH14 CELSR1 IGF1R MICAL3 ABTB2

5.06e-0619410067002937e8903e037332a215d00fbc7c7843b33f2
ToppCellControl_saline-Epithelial_airway|Control_saline / Treatment groups by lineage, cell group, cell type

RHCG DNAH10 DNAH7 GSTA3 CELSR1 TMC5

5.69e-061981006e6863238e022ecfb6a8e3f4b7661b376e92c5d8f
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ROCK2 CABP1 MDGA2 GRIN2B PAM PRKCE

5.69e-0619810068ab40fae14fe02e39bc8c8da187a5cd60c787643
ToppCellControl_saline-Epithelial_airway-airway_epithelial|Control_saline / Treatment groups by lineage, cell group, cell type

RHCG DNAH10 DNAH7 GSTA3 CELSR1 TMC5

5.69e-061981006e7aa42e5fbd42c68f50cda4a8f3aa464c862c007
ToppCellLPS_IL1RA_TNF-Epithelial_alveolar-AT_1-Differentiating_AT2|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

ARHGEF28 ACER1 NEXMIF CELSR1 ABCC8 TTC39A

5.86e-061991006121de4e02585de3a3010398387c523bacf8ce546
ToppCellNeuronal-Inhibitory-iB-iB_4(SST)-ADGRG6-|Neuronal / cells hierarchy compared to all cells using T-Statistic

PCSK5 GAD2 PRTG GRID2 GRIK1 ABTB2

6.03e-062001006a9cdddc4e985dae59521e557479c24fcc2ac727d
ToppCellLPS_IL1RA-Epithelial_airway-airway_epithelial|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

RHCG DNAH10 DNAH7 GSTA3 TMC5 WNK2

6.03e-062001006cf191104484bfb2b9f87de416b9453135f8833c1
ToppCellNeuronal-Inhibitory-iB-iB_4(SST)-ADGRG6--L3-5|Neuronal / cells hierarchy compared to all cells using T-Statistic

PCSK5 GAD2 PRTG GRID2 GRIK1 ABTB2

6.03e-06200100633b9199e0dfc267e2cea20b82d1c167f8adcc635
ToppCellLPS_IL1RA-Epithelial_airway|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

RHCG DNAH10 DNAH7 GSTA3 TMC5 WNK2

6.03e-062001006a5ae33dd4dc1ff6e1a1eec22c4d523d5ab657607
ToppCellNeuronal-Inhibitory-iB-iB_4(SST)-ADGRG6|Neuronal / cells hierarchy compared to all cells using T-Statistic

PCSK5 GAD2 PRTG GRID2 GRIK1 ABTB2

6.03e-0620010069719fabddc34051949468a7520289e3c750de4f8
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Principal_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ACER1 TOX GRIN2B ABCB1 CDH4

2.04e-0514710052885978bcfc5623967c0c1204dadf5c78c74a082
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal--glomerular_mesenchymal_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

MCF2 MDGA2 GRID2 ABCC8 TMC5

2.55e-0515410053211f003f4d1735c7cab9b6cc68af3e0bbfba35e
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

MCF2 MDGA2 GRID2 ABCC8 TMC5

2.55e-051541005c0fe767fc9ab45b2dfa71171f2a673a4a8decbaf
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal--glomerular_mesenchymal_cell-Renin-positive_Juxtaglomerular_Granular_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

MCF2 MDGA2 GRID2 ABCC8 TMC5

2.55e-0515410054c2a7590791c2255b15dab82c3622f71f9ffd949
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic-precursor_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

WDR64 DNAH10 MROH2A GRIN2B PKHD1L1

3.06e-051601005c381ec6be8cf887861cc18f831a20db42f953fe1
ToppCellfacs-Lung-nan-3m-Endothelial-Capillary_Type_1_Cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TNFRSF25 DNAH10 MROH2A GRIN2B WNK2

3.06e-051601005f2cdee5a9e3b0eb125d6be7b5d239eb04333ae41
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Sst-Sst_Calb2_Pdlim5|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

PCSK5 GAD2 TOX CDH4 ABTB2

3.06e-051601005dd16ca90feb3ae88b6409d6c278b4765da565514
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic-pre_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

WDR64 DNAH10 MROH2A GRIN2B PKHD1L1

3.06e-05160100525c8f3d2a6d14ff0ca0b965fce89d3ff22f40585
ToppCellChildren_(3_yrs)-Epithelial-lung_goblet_cell-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

INSR CELSR1 EPHA2 TMC5 WNK2

3.16e-0516110052d63b279d9a5132e1c09b03930bf9039036d24a2
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell-mesangial_typical|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

MCF2 MDGA2 GRID2 ABCC8 TMC5

3.16e-0516110051b805f77790aeb8a71b08bfac2fe2eed7343258f
ToppCellPND10-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ARHGEF28 MROH2A PKHD1L1 CELSR1 PALM

3.45e-0516410054cfc9f92e49f86d3639e018b35b6a60dc62f494a
ToppCellPND10-Endothelial-Endothelial_lymphatic-Lymphatic_EC|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ARHGEF28 MROH2A PKHD1L1 CELSR1 PALM

3.45e-0516410057a8e5ef52a8fd2877d59ef0696af8a7af90bbed6
ToppCellPND10-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC-LEC_mature|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ARHGEF28 MROH2A PKHD1L1 CELSR1 PALM

3.45e-0516410055e5bd81414ea2d64f73cdef19a0a78c17bec8c18
ToppCellPND10-Endothelial-Endothelial_lymphatic|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ARHGEF28 MROH2A PKHD1L1 CELSR1 PALM

3.45e-051641005f13b8d9b7f42193f333d9a77571a1dde6bbb48d8
ToppCell368C-Endothelial_cells-Endothelial-F_(Lymphatics)|368C / Donor, Lineage, Cell class and subclass (all cells)

EPHB4 GRIN2B PKHD1L1 PALM WNK2

3.87e-051681005a74c8a9e3299183fba31ce3053ef325b5dbcd104
ToppCell3'-GW_trimst-1-SmallIntestine-Epithelial-neuro-epithelial-L_cells_(PYY+)|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

GAD2 ABCC8 PAM TTC39A CDH4

3.87e-0516810050f736d58cb0ff042fa3ce58e36bde37b6976f8fc
ToppCell368C-Endothelial_cells-Endothelial-F_(Lymphatics)-|368C / Donor, Lineage, Cell class and subclass (all cells)

EPHB4 GRIN2B PKHD1L1 PALM WNK2

3.87e-051681005dae37b316ce80dfe4236c4ed7f0d4e7c340fa7b6
ToppCellmetastatic_Brain-Myeloid_cells-pDCs|Myeloid_cells / Location, Cell class and cell subclass

WDR64 AKAP8L EPHA2 TSPYL4 ABTB2

3.87e-0516810054bf3f85aac4b335efa93d22c9ce7b153cb5ce152
ToppCellCOVID-19-kidney-PEC|COVID-19 / Disease (COVID-19 only), tissue and cell type

ARHGEF28 DNAH7 ABCB1 BMP7 MICAL3

3.87e-051681005a086c306be430adf0632ba53e98cd8014d2de330
ToppCellFrontal_cortex-Neuronal-Inhibitory|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

GAD2 GRIK1 MINDY2 TTC39A TSPYL4

3.98e-05169100578eb70dd916724e476eabccf18fb7fcec4210308
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal--glomerular_mesenchymal_cell-Renin-positive_Juxtaglomerular_Granular_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

MCF2 MDGA2 GRID2 ABCC8 TMC5

4.09e-05170100599dd734c0972a40d5381e8e2d96bdaa31f6d06e6
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal--glomerular_mesenchymal_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

MCF2 MDGA2 GRID2 ABCC8 TMC5

4.09e-0517010053a14eeae221b8bb0bd0dadcb8e7a603431240a1e
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

MCF2 MDGA2 GRID2 ABCC8 TMC5

4.09e-051701005cdb6fad277f284c3fd5a6f45672a8edc24715882
ToppCellfacs-Spleen-nan-24m-Lymphocytic-Cd3e_T_cell|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TNFRSF25 TOX BMP7 CELSR1 IGF1R

4.45e-051731005f2eeff86e7dc7f4e3c36f775777d56685d7096cf
ToppCellfacs-Spleen-nan-24m-Lymphocytic-CD4-positive,_alpha-beta_T_cell|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TNFRSF25 TOX BMP7 CELSR1 IGF1R

4.57e-051741005096bc6f1889f2bbadfe1e1a3eb6ae569aaa2ee7d
ToppCelldroplet-Lung-18m-Hematologic-lymphocytic-CD4-positive,_alpha-beta_T_cell-CD4-positive,_alpha-beta_T_cell_l21|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

TNFRSF25 TOX BMP7 CELSR1 LYG1

4.70e-051751005e7b0eda141b638f1aad9938aaa76b1ce80171be9
ToppCell356C-Lymphocytic-NK_cells-NK_cell_C|356C / Donor, Lineage, Cell class and subclass (all cells)

PCSK5 GRIK1 ABCB1 CABP4 FGR

5.09e-0517810057203149864cc8d5ae25329fdbf15c6b73c3d3595
ToppCellCOVID-19-Myeloid-MoAM4|Myeloid / Condition, Lineage and Cell class

EPHB4 TOX HYKK DNAH14 ABCB1

5.09e-051781005fe0017e6a1f23dc45f644b9acacc7e8aa80d0116
ToppCell5'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.3.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DNAH10 DNAI3 DNAH7 SYNGAP1 TMC5

5.23e-0517910055e5f1cdf4aa66868d45b74ba91e20e848a3cbaff
ToppCell3'-Adult-LargeIntestine-Endothelial-lymphatic_endothelial-LEC5_(CLDN11+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

GRIK1 MINDY2 PKHD1L1 PALM FGR

5.23e-051791005ec1d7017da325647b629de703135a404bbdc627d
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Cortical_Collecting_Duct_Principal_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

TOX GRIN2B ABCB1 GSTA3 ABTB2

5.37e-051801005023ec0b080c8a5cd0f36e83c6b17d4be3c01edb5
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

MDGA2 SLC35F4 BMP7 PRKCI SIPA1L2

5.51e-0518110055f2d3a08577c440c944778d07aa993c6e7873f3d
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell-Parietal_Epithelial_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

MDGA2 SLC35F4 BMP7 PRKCI SIPA1L2

5.51e-051811005c7c5f7d4c397b4613c772413a0a679377efffff3
ToppCellfacs-Spleen-nan-18m-Lymphocytic-CD4-positive,_alpha-beta_T_cell|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TNFRSF25 TOX BMP7 CELSR1 IGF1R

5.66e-051821005fbe5bdd642b86010dbef0a567b25c69c7335688f
ToppCellfacs-Spleen-nan-18m-Lymphocytic-Cd3e_T_cell|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TNFRSF25 TOX BMP7 CELSR1 IGF1R

5.66e-051821005da3e9093cba791c7c282eb044656046252a32789
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L5-6_LAMP5_SFTA3_(Lamp5_Lhx6_2)|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

GAD2 TOX SLC35F4 BMP7 GKN1

5.80e-051831005f8b636391f752e379a5c5575fd898bdf0907a3b8
ToppCellEpithelial-lung_goblet_cell|World / Lineage, Cell type, age group and donor

ARHGEF28 INSR CELSR1 TMC5 WNK2

5.80e-051831005940cbe298e9c53b5622af09264586ed823d3141f
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DNAH10 MROH2A MDGA2 GRIN2B PKHD1L1

5.96e-0518410052cbed6462fea2622871bb7e49b0df3d984239281
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DNAH10 MROH2A MDGA2 GRIN2B PKHD1L1

5.96e-051841005ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DNAH10 MROH2A MDGA2 GRIN2B PKHD1L1

5.96e-0518410052b19a8c5f823e00812908b23e66bb4e563278aff
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1_ADARB2_ADAM33|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

GAD2 GRIK1 SLC35F4 SIPA1L2 CDH4

6.11e-051851005487fa382232564f075960899d50afa0edae5d258
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1_VIP_PRSS8|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PCSK5 GAD2 SLC35F4 TMC5 CDH4

6.11e-0518510054c42bd3cd72f91f4d4ebb849069a03761a2cd662
ToppCell3'-Distal_airway-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(non-nasal)-Club_(non-nasal)_L.0.4.1.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CYP21A2 INSR PAM TMC5 WNK2

6.27e-05186100555fe25f4d0f2bc0fd4802a0a375169f2c41472fc
ToppCellAnterior_Cingulate_gyrus_(CgG)|World / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PCSK5 ARHGEF28 BIRC3 GRID2 DNAH14

6.27e-05186100532af3f211f9ad5d5c6b86b83325cfbf2f8466b56
ToppCellAdult-Epithelial-club_cell-D231|Adult / Lineage, Cell type, age group and donor

INSR CELSR1 IGF1R TMC5 WNK2

6.43e-051871005ee59d7d3de5879738ff0b9c3ea5e4847fb48cb86
ToppCell3'-Adult-SmallIntestine-Epithelial-mature_enterocytic-Enterocyte|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PCSK5 CES2 ABCB1 FBP1 TMC5

6.43e-0518710059042bd0f57213a51503d9df2e4dce3209b7772d3
ToppCell3'-GW_trimst-1-SmallIntestine-Hematopoietic-T_cells-LTi-like_NCR+_ILC3|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TNFRSF25 BIRC3 ABCB1 TTC7A FGR

6.43e-05187100542b20d7f0a4f9195b3d71dc0e089b5e0914ebcbb
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L5-6_LAMP5_SFTA3_(Lamp5_Lhx6_2)|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

GAD2 TOX GRIK1 SLC35F4 BMP7

6.59e-0518810058268574584e5fb869a6cb8bbd7135cd7454a6a25
ToppCellLPS-IL1RA+antiTNF-Endothelial-Endothelial-Alv_Cap|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

YES1 ABCB1 PRKCE SIPA1L2 DISP1

6.59e-05188100573f6ec915934154f435a376cb274b058ff7c5f35
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L5-6_LAMP5_SFTA3_(Lamp5_Lhx6_2)|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

GAD2 TOX GRIK1 SLC35F4 BMP7

6.59e-0518810054544552ebd67e9eb3e40d8511bb2b03a6e1178f8
ToppCellChildren_(3_yrs)-Endothelial-endothelial_cell_of_lymph_vessel-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

EPHB4 GRIN2B PKHD1L1 PALM MICAL3

6.59e-051881005aeecbc057dc823f8fcea8a98f18d213bacc7f4db
ToppCellE18.5-Endothelial-Endothelial_blood-vessel-Macrovascular_EC|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

EPHB4 PCSK5 TOX PLXND1 PAM

6.76e-051891005d17e8467699c7ca7694a313c26111f085df5204e
ToppCellCOVID-19-lung-Secretory|lung / Disease (COVID-19 only), tissue and cell type

ARHGEF28 INSR CELSR1 TMC5 WNK2

6.76e-05189100584d48e3ed25bebb8bb8074b3a2c5e2e88cff7f25
ToppCellAdult-Epithelial-club_cell|Adult / Lineage, Cell type, age group and donor

INSR CELSR1 IGF1R TMC5 WNK2

6.93e-051901005756bff697d30aec56c0ebfca94295f084a15bf37
ToppCellfacs-Lung-3m-Endothelial-lymphatic_endothelial|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

EPHB4 YES1 PKHD1L1 CELSR1 PALM

6.93e-051901005a1514d2186eb4fe569971ab22dc0c17d353fb94a
ToppCellfacs-Lung-3m-Endothelial-lymphatic_endothelial-lymphatic_endothelial_cell|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

EPHB4 YES1 PKHD1L1 CELSR1 PALM

6.93e-0519010050bb954a94317cfc742b9b6221bb80f8baa6d3ff1
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Cortical_Collecting_Duct_Principal_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

TOX NEXMIF GRIN2B ABCB1 ABTB2

6.93e-051901005b7f8c2bb9459f1d7c1690069dd5a25a81a57cc84
ToppCellCOVID-19-Epithelial_cells-Airway_goblet|COVID-19 / group, cell type (main and fine annotations)

ARHGEF28 NEXMIF CELSR1 TMC5 WNK2

6.93e-05190100551ca9ef4df3220487152fcf684147730637c7cc1
ToppCellfacs-Lung-3m-Endothelial-lymphatic_endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

EPHB4 YES1 PKHD1L1 CELSR1 PALM

6.93e-05190100526e2237f65cb43723c5da853831b40df2982d6e4
ToppCellEpithelial|World / Lineage, Cell type, age group and donor

TOX DNAH14 CELSR1 PRKCI TMC5

7.28e-051921005499e8893afea5e6d3371e0bd018f7e86a524d669
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

ROCK2 TOX NEXMIF ABCB1 ABTB2

7.28e-0519210052510f22197502f60fd266b7f42eff040f25b8ae7
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Cortical_Collecting_Duct_Principal_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

ROCK2 TOX NEXMIF ABCB1 ABTB2

7.28e-051921005e8e316f396834bcd34843e56e1d86f310fd6aada
ToppCell3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.3.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DNAH10 DNAI3 DNAH7 GSTA3 TMC5

7.28e-0519210051b6cac8156e608061e1405e36e18d185b6fa8f6f
ToppCelldroplet-Heart-HEART-1m-Endothelial-endocardial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EPHB4 NEXMIF PKHD1L1 PALM CDH4

7.46e-051931005d0a5f212f8e8a13dbbe3e41df92548ef82eef70b
ToppCellNS-moderate-d_0-4|moderate / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

DNAH10 DNAI3 DNAH7 CELSR1 STEAP3

7.46e-051931005ea345d34440b25f65358a53dc72831998d1c3620
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ARHGEF28 DNAH7 DNAH14 IGF1R ABTB2

7.46e-0519310053866667dd221612589ae50f5c52f73a183a49ce6
ToppCellLPS-IL1RA-Endothelial-Endothelial-Activated_Alv_Cap|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

MDGA2 ABCB1 PRKCE SIPA1L2 DISP1

7.46e-051931005a3636c35ed25aabe2f1aba016c9fe125327bbfaf
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L3-5_SST_MAFB|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PCSK5 GAD2 PRTG GRID2 GRIK1

7.46e-051931005e74fdc8718fe0933e1f4dd3fe37e2134983b99b6
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L3-5_SST_MAFB|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PCSK5 GAD2 PRTG GRID2 GRIK1

7.46e-051931005658c2b30a4d806c5ce78ea4392fe8eb86b8d1e99
ToppCellFetal_29-31_weeks-Epithelial|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

TOX DNAH14 CELSR1 PRKCI TMC5

7.46e-051931005a0ca3231992f14abcf1a6129573bace320e89d2a
ToppCellLPS-IL1RA-Endothelial|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

YES1 ABCB1 PRKCE SIPA1L2 DISP1

7.65e-05194100543f92b0533e26633dc94cce554045d641ef8fd76
ToppCellnucseq-Epithelial-Epithelial_Alveolar-Secretory/RAS|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

INSR CELSR1 EPHA2 TMC5 WNK2

7.65e-0519410050cd4363627acd419e00d6d32f6dce10430aa6487
ToppCellnucseq-Epithelial-Epithelial_Alveolar-Secretory/RAS-RAS|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

INSR CELSR1 EPHA2 TMC5 WNK2

7.65e-051941005a58841b34efe673671a9a059238e044a7254b279
ToppCellLPS-IL1RA-Endothelial-Endothelial|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

YES1 ABCB1 PRKCE SIPA1L2 DISP1

7.65e-0519410051d39d968730a7e85b6161c1c8a6bd38afe9bcad7
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L3-5_SST_MAFB|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PCSK5 GAD2 PRTG GRID2 GRIK1

7.65e-0519410051bcb3fafd498614f7bac2b1c9b7de56e39110f65
ToppCell3'-GW_trimst-1.5-SmallIntestine-Hematopoietic|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TNFRSF25 BIRC3 ABCB1 STXBP2 FGR

7.83e-051951005441345d33f839a9e9222e790752b5603ff572bf2
ToppCell3'-Distal_airway-Epithelial-Epithelial_transtional-secretory-tracheobronchial_goblet_cell-Goblet_(subsegmental)-Goblet_(subsegmental)_L.0.4.3.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

INSR CELSR1 PAM TMC5 WNK2

7.83e-0519510052a9a36df1dbc4eac77a8ddbe939ec8a8d6c41464
ToppCellwk_15-18-Epithelial-Proximal_epithelial-Ciliated|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

DNAH10 DNAI3 DNAH7 GSTA3 TMC5

7.83e-051951005cfcf554b436083179dea1d6fd6e3a800ea2430fe
ToppCell3'-Distal_airway-Epithelial-Epithelial_transtional-secretory-tracheobronchial_goblet_cell-Goblet_(subsegmental)|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

INSR CELSR1 PAM TMC5 WNK2

7.83e-051951005576142b4e75457c0973051bccc4163bd624496af
ToppCell3'-Distal_airway-Epithelial-Epithelial_transtional-secretory-tracheobronchial_goblet_cell|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

INSR CELSR1 PAM TMC5 WNK2

7.83e-0519510058f151066ad3ebd9661ea0b733f03c2ce1518f9ad
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

TOX NEXMIF EPHA2 TMC5 ABTB2

7.83e-0519510053d6d3de8ada6dce3dc789c15b50cc066e7100496
ToppCellParenchymal-NucSeq-Epithelial-Epi_airway_basal|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

HYKK BMP7 CELSR1 SIPA1L2 WNK2

8.22e-051971005107cb153ea7fc74bbd244dbb9d0499c0a8506724
ToppCell5'-Adult-SmallIntestine-Epithelial|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PCSK5 CES2 FBP1 TMC5 BAIAP2L2

8.42e-0519810058d629492d2199de8e036c19e9dacceb9c9e721a0
ToppCellLPS_only-Epithelial_airway-airway_epithelial|LPS_only / Treatment groups by lineage, cell group, cell type

INSR DNAH7 GSTA3 TMC5 WNK2

8.42e-051981005e035380578c01b0243bfef29ca9b50cc17cce771
Drugphenobarbital

UGT1A6 CYP21A2 GRID2 GRIK1 GRIN2B CES2 ABCB1 GSTA3 PRKCE PRKCI TAT

5.35e-0736010011CID000004763
Drug2-amino-3-phosphonopropionic acid

GAD2 GRID2 GRIK1 GRIN2B PRKCE PRKCI

1.05e-06761006CID000003857
Drugsoman

GRIK1 GRIN2B CES2 PRKCE PRKCI TAT

3.24e-06921006CID000007305
DrugVX-745

EPHB4 YES1 EPHA2 FGR

4.13e-06251004CID003038525
DrugRose Bengal

UGT1A6 ABCB1 GSTA3

6.77e-0691003ctd:D012395
DrugFce 26644

ABCB1 IGF1R TAT

6.77e-0691003CID000132977
DrugDichlorodiphenyl Dichloroethylene

MDGA2 GRIK1 GRIN2B PLXND1 ABCB1 SYNGAP1 ATF6 IGF1R PAM

7.46e-063021009ctd:D003633
DrugL-Glutamic Acid

GAD2 GRID2 GRIK1 GRIN2B TAT

1.24e-05681005DB00142
Drug1xgj

AMD1 GAD2 TNFRSF25 INSR TAT

1.24e-05681005CID000657106
Drug1-aminoindan-1,5-dicarboxylic acid

GRID2 GRIK1 GRIN2B PRKCE

1.30e-05331004CID000002071
Drugfelbamate

GAD2 GRID2 GRIK1 GRIN2B ABCB1

1.43e-05701005CID000003331
Drugcystamine

RHCG ROCK2 GRIN2B ABCB1 GSTA3 PRKCE EIF2AK3

1.53e-051811007CID000002915
DrugN-methyl-N-(6-methoxy-1-phenyl-1,2,3,4-tetrahydronaphthalen-2-ylmethyl)aminomethylcarboxylic acid

GRID2 GRIK1 GRIN2B PRKCI

1.65e-05351004ctd:C520612
DrugBCECF

RHCG ABCB1 PAM PRKCE PRKCI

1.75e-05731005CID004241719
DrugC6H12NO5P

GAD2 GRID2 GRIK1 GRIN2B

1.85e-05361004CID000104962
DrugInsulin Glargine

INSR IGF1R

1.91e-0521002ctd:D000069036
DrugInsulin Lispro

INSR IGF1R

1.91e-0521002DB00046
DrugInsulin Glargine

INSR IGF1R

1.91e-0521002DB00047
DrugNC-1100

GAD2 ABCB1

1.91e-0521002CID000146395
DrugTamoxifen citrate [54965-24-1]; Down 200; 7uM; PC3; HT_HG-U133A

ROCK2 SENP3 UNC45A CES2 TMC5 NIPBL ABTB2

2.48e-0519510072050_DN
Drug16-phenyl tetranor Prostaglandin E2; Down 200; 10uM; PC3; HT_HG-U133A

ARHGEF28 ELP1 PLXND1 UNC45A IGF1R PRKCE TAT

2.65e-0519710077546_DN
DrugRiluzole hydrochloride; Up 200; 14.8uM; PC3; HT_HG-U133A

TNFRSF25 PLXND1 GSTA3 BMP7 PALM PRKCE TAT

2.65e-0519710073666_UP
DrugCP-690334-01 [459212-38-5]; Up 200; 1uM; MCF7; HT_HG-U133A

CABP1 TNFRSF25 ARHGEF28 INSR BIRC3 DNAH7 IGF1R

2.74e-0519810074383_UP
DrugAdamantamine fumarate [80789-67-9]; Up 200; 9.6uM; MCF7; HT_HG-U133A

TNFRSF25 ELP1 MINDY2 PALM TTC39A TMC5 ULK2

2.83e-0519910073280_UP
Drugthiokynurenic acid

GAD2 GRIK1 GRIN2B

3.60e-05151003CID003035667
Drugamphetamine

GAD2 GRIK1 GRIN2B IGF1R MRO PRKCE PRKCI HPS5

3.66e-052841008CID000003007
DrugJoro spider toxin

GRID2 GRIK1 GRIN2B LATS1

3.79e-05431004CID000119582
DrugEthylnitrosourea

PCSK5 CYP21A2 INSR GRID2 GRIK1 CELSR1 IGF1R DISP1

4.35e-052911008ctd:D005038
Drug1-(1-methanesulfonylpiperidin-4-yl)-3-(4-trifluoromethoxyphenyl)urea

INSR ATF6 EIF2AK3

4.42e-05161003ctd:C561619
DrugAdOx

INSR LATS1 ULK1

4.42e-05161003CID000099920
Drugaurothioglucose

TNFRSF25 INSR INSRR PRKCE PRKCI

4.83e-05901005CID000006104
DrugAC1MZZID

INSR PAM

5.71e-0531002CID003908947
Drugpropylphosphonic acid

GRIK1 GRIN2B

5.71e-0531002CID006328099
DrugMecasermin

INSR IGF1R

5.71e-0531002DB01277
DrugBM-223

ABCB1 ABCC8

5.71e-0531002CID002760592
DrugAC1L1H8N

GRIK1 GRIN2B

5.71e-0531002CID000004023
DrugBM 208

ABCB1 ABCC8

5.71e-0531002CID002782755
Drug2,4-dihydroxyphenylacetic acid

GRIK1 YES1

5.71e-0531002CID000069199
Drugavermectin

GRID2 GRIK1 GRIN2B ABCB1

5.88e-05481004CID006450460
Drugvanadyl

AMD1 DNAH10 INSR STAT6 ABCB1 IGF1R PRKCE PRKCI

6.34e-053071008CID000061671
DrugCgp-42700

ABCB1 PRKCE PRKCI

6.39e-05181003CID000188390
DrugNile red

ABCB1 NSDHL ABCC8 PAM

6.91e-05501004CID000065182
Drugethyl methylphosphinate

TOX CES2 ABCB1 NSDHL

7.47e-05511004CID006328184
DrugLY354740

GRID2 GRIK1 GRIN2B TAF1L

7.47e-05511004CID000114827
DrugII-E

CARM1 COG7 POLE CYP21A2 PALM

8.38e-051011005CID006540268
Drugbifenthrin

CES2 ABCB1 GSTA3 FBP1 BAIAP2L2

9.20e-051031005ctd:C099952
Drugloperamide

GRIN2B CES2 ABCB1 PRKCE PRKCI

1.01e-041051005CID000003954
DrugAzitidin

POLE UGT1A6 ABCB1 ABCC8 PRKCE PRKCI

1.03e-041691006CID000005726
Drugriddelliine

CES2 ABCB1 GSTA3 ABCC8

1.08e-04561004ctd:C013672
Drugracemethorphan

GRID2 GRIK1 GRIN2B ABCB1 MRO

1.10e-041071005CID000003008
DrugNSC638615

CYP21A2 ELP1 PLXND1 ABCB1 PRKCE

1.10e-041071005CID000097535
DrugNicorette

ROCK2 UGT1A6 CYP21A2 GRID2 GRIK1 GRIN2B BMP7 PRKCE PRKCI EIF2AK3

1.12e-0452910010CID000000942
DrugAC1L1GKK

INSR IGF1R

1.14e-0441002CID000003725
DrugXanthenes

UGT1A6 ABCB1

1.14e-0441002ctd:D014966
DrugSN-38 carboxylate form

CES2 ABCB1

1.14e-0441002CID000443148
Drughypericin

ABCB1 GSTA3 PRKCE PRKCI FGR

1.15e-041081005CID005281051
Drugimatinib

EPHB4 ROCK2 INSR INSRR YES1 ABCB1 IGF1R EPHA2 FGR

1.17e-044301009CID000005291
DrugU0126

INSR BIRC3 GRIK1 STAT6 ABCB1 IGF1R PRKCE EIF2AK3 TAT

1.17e-044301009CID000005637
Drugenglitazone

INSR FBP1 ABCC8

1.19e-04221003CID000060303
DrugDAPH2

INSR IGF1R PRKCE PRKCI

1.24e-04581004CID006711154
Druglithocholyltaurine

BIRC3 GRIN2B ABCB1 PRKCE PRKCI EIF2AK3

1.24e-041751006CID000010595
Drugdichloromethanediamine

PCSK5 CABP1 TNFRSF25 BIRC3 ABCB1 IGF1R EPHA2 PAM PRKCE PRKCI

1.31e-0453910010CID005311048
Drug3-nitropropionic acid

GAD2 GRIK1 GRIN2B ABCB1 ABCC8 EIF2AK3

1.36e-041781006CID000001678
DrugYM90K

GRID2 GRIK1 GRIN2B

1.37e-04231003CID005486547
Drug3,5-dihydroxyphenylglycine

GRID2 GRIK1 GRIN2B EIF2AK3

1.41e-04601004CID000108001
DrugCGP 39653

GRID2 GRIK1 GRIN2B

1.56e-04241003CID006437837
DrugLetrozole [112809-51-5]; Up 200; 14uM; HL60; HT_HG-U133A

GAD2 INSR BMP7 IGF1R LATS1 FGR

1.68e-0418510062916_UP
Drugadenosine 3',5'-cyclic phosphate

CARM1 CYP21A2 INSR BIRC3 GRIK1 AKAP8L ATF6 LATS1 FBP1 PAM PRKCE PRKCI TAT

1.68e-0490710013CID000000274
DrugAC1ND2OB

CARM1 UGT1A6 ABCB1 PRKCE PRKCI FGR TAF1L

1.70e-042651007CID004568637
DrugAC1L1D59

INSR GRIK1 GRIN2B ABCB1 PRKCE PRKCI EIF2AK3

1.74e-042661007CID000002199
Druggavestinel

GRID2 GRIK1 GRIN2B

1.76e-04251003CID006450546
DrugDexamethasone acetate [1177-87-3]; Down 200; 9.2uM; PC3; HT_HG-U133A

TNFRSF25 TOX CES2 IGF1R TMC5 ABTB2

1.83e-0418810062079_DN
DrugPQ401

INSR IGF1R

1.89e-0451002CID009549305
Drugphloxine

UGT1A6 ABCB1

1.89e-0451002ctd:C085059
DrugSP600125

ROCK2 INSR BIRC3 ABCB1 GSTA3 PRKCE PRKCI TAT

1.97e-043621008CID000008515
DrugBMS-764459

UGT1A6 CES2 GSTA3

1.99e-04261003ctd:C584056
Drug3-octanone

PCSK5 TNFRSF25 YES1

1.99e-04261003CID000246728
DrugPHA-00846566E [724718-26-7]; Down 200; 10uM; PC3; HT_HG-U133A

EPHB4 TNFRSF25 ARHGEF28 IGF1R TTC39A ULK2

2.00e-0419110067086_DN
Drugfluo-3

GRIK1 GRIN2B ABCB1 PRKCE PRKCI

2.04e-041221005CID000104978
Drugtyrphostin 25

INSR STAT6 IGF1R PRKCE PRKCI

2.04e-041221005CID000002061
Drugethoxytriethyleneglycol

UGT1A6 GRIK1 PRKCE PRKCI

2.05e-04661004CID000008190
DrugDiclofenac

ROCK2 UGT1A6 INSR STAT6 ABCB1 GSTA3 CDC7 IGF1R PRKCI EIF2AK3

2.05e-0457010010ctd:D004008
Drug17-hydroxyprogesterone

GAD2 TNFRSF25 CYP21A2 NSDHL PALM

2.12e-041231005CID000006238
Drugpalmitate

GAD2 TNFRSF25 ACAD9 INSR LATS1 PALM PAM EIF2AK3

2.16e-043671008CID000000985
DrugDibucaine [85-79-0]; Down 200; 11.6uM; MCF7; HT_HG-U133A

EPHB4 GAD2 TNFRSF25 PLXND1 MINDY2 LATS1

2.17e-0419410064149_DN
Drugradicicol, diheterospora chlamydosporia; Down 200; 0.1uM; PC3; HT_HG-U133A

TNFRSF25 SENP3 CES2 IGF1R MICAL3 ABTB2

2.17e-0419410061219_DN
DrugAmpyrone [83-07-8]; Down 200; 19.6uM; PC3; HT_HG-U133A

EPHB4 ROCK2 TNFRSF25 SENP3 IGF1R ABTB2

2.17e-0419410062086_DN
DrugNSC618487

ROCK2 TNFRSF25 CYP21A2 INSR BIRC3 GRIK1 GRIN2B YES1 ABCB1 EPHA2 PRKCE PRKCI FGR

2.22e-0493310013CID000005279
Drugilmofosine

ABCB1 PRKCE PRKCI

2.23e-04271003CID000055008
Drugpseudohypericin

ABCB1 PRKCE PRKCI

2.23e-04271003CID005281751
DrugL-689,560

GRID2 GRIK1 GRIN2B

2.23e-04271003CID000121918
DrugParbendazole [14255-87-9]; Up 200; 16.2uM; MCF7; HT_HG-U133A

PCSK5 GAD2 TNFRSF25 INSR MINDY2 PALM

2.30e-0419610064357_UP
DrugMafenide hydrochloride [138-37-4]; Down 200; 18uM; PC3; HT_HG-U133A

TNFRSF25 POLE PLXND1 CES2 LATS1 ABTB2

2.30e-0419610065079_DN
DrugPenbutolol sulfate [38363-32-5]; Down 200; 5.8uM; MCF7; HT_HG-U133A

EPHB4 ROCK2 ATF6 STXBP2 EPHA2 PALM

2.30e-0419610063534_DN
DrugDimethadione [695-53-4]; Up 200; 31uM; HL60; HT_HG-U133A

MCF2 GRIK1 GRIN2B ABCB1 BMP7 ABTB2

2.30e-0419610063029_UP
Drugponatinib

EPHB4 YES1 EPHA2 FGR

2.30e-04681004ctd:C545373
DrugTestosterone Propionate

GAD2 INSR IGF1R EPHA2

2.30e-04681004ctd:D043343
Drug0198306-0000 [212631-61-3]; Down 200; 10uM; MCF7; HT_HG-U133A

AMD1 UNC45A BMP7 EPHA2 MICAL3 NIPBL

2.36e-0419710067064_DN
DrugFlavoxate hydrochloride [3717-88-2]; Up 200; 9.4uM; MCF7; HT_HG-U133A

MCF2 STAT6 PALM TMC5 ULK2 TAT

2.36e-0419710067405_UP
DrugOrnidazole [16773-42-5]; Down 200; 18.2uM; PC3; HT_HG-U133A

TNFRSF25 PLXND1 LATS1 PRKCE ULK2 TAT

2.43e-0419810065064_DN
Diseasehigh grade glioma (implicated_via_orthology)

POLE INSR INSRR ABCB1 IGF1R PRKCI

8.28e-09441006DOID:3070 (implicated_via_orthology)
Diseasediabetes mellitus (implicated_via_orthology)

INSR INSRR BMP7 IGF1R

1.75e-06261004DOID:9351 (implicated_via_orthology)
Diseasealcohol dependence (implicated_via_orthology)

INSR INSRR IGF1R

3.13e-0691003DOID:0050741 (implicated_via_orthology)
Diseasesleep disorder (implicated_via_orthology)

INSR INSRR IGF1R

6.11e-06111003DOID:535 (implicated_via_orthology)
Diseasediabetic neuropathy (implicated_via_orthology)

INSR INSRR IGF1R

1.34e-05141003DOID:9743 (implicated_via_orthology)
DiseaseMetastatic melanoma

EPHB4 ROCK2 PRKCI ULK2

3.45e-05541004C0278883
Diseasecancer (implicated_via_orthology)

POLE YES1 NSDHL LATS1 GET3 FGR NIPBL

3.68e-052681007DOID:162 (implicated_via_orthology)
Diseasesphingomyelin 24:1 measurement

CELSR1 IGF1R MRO

6.37e-05231003EFO_0010398
Diseasecarcinoma (implicated_via_orthology)

YES1 LATS1 PRKCI FGR

6.75e-05641004DOID:305 (implicated_via_orthology)
Diseasefetal alcohol spectrum disorder (biomarker_via_orthology)

GRIN2B IGF1R

6.79e-0541002DOID:0050696 (biomarker_via_orthology)
DiseaseNeonatal diabetes mellitus

INSR ABCC8 EIF2AK3

8.23e-05251003C0158981
Diseasebody weight

PCSK5 NEXMIF CYP21A2 INSR MDGA2 GRID2 DNAH14 IGF1R ABCC8 HACE1 PRKCE FGR EIF2AK3 NIPBL

9.00e-05126110014EFO_0004338
Diseasegestational diabetes (biomarker_via_orthology)

INSR IGF1R

1.13e-0451002DOID:11714 (biomarker_via_orthology)
Diseaseglucose metabolism disease (implicated_via_orthology)

INSR INSRR IGF1R

1.16e-04281003DOID:4194 (implicated_via_orthology)
Diseasecolorectal cancer (implicated_via_orthology)

POLE YES1 FGR

1.43e-04301003DOID:9256 (implicated_via_orthology)
DiseaseGlcNAc sulfate conjugate of C21H34O2 steroid measurement

CELSR1 MRO

1.69e-0461002EFO_0800663
Diseasetoxic encephalopathy (is_implicated_in)

ABCB1 IGF1R

1.69e-0461002DOID:3602 (is_implicated_in)
DiseaseEpilepsy, Cryptogenic

NEXMIF GRIN2B ABCB1 SYNGAP1

1.77e-04821004C0086237
DiseaseAwakening Epilepsy

NEXMIF GRIN2B ABCB1 SYNGAP1

1.77e-04821004C0751111
DiseaseAura

NEXMIF GRIN2B ABCB1 SYNGAP1

1.77e-04821004C0236018
DiseaseParkinson Disease

INSR ABCB1 IGF1R FBP1

2.04e-04851004C0030567
Diseasegestational diabetes (is_implicated_in)

GAD2 INSR

3.14e-0481002DOID:11714 (is_implicated_in)
DiseaseVentricular Septal Defects

PCSK5 YES1

3.14e-0481002C0018818
Diseasepneumococcal meningitis

CELSR1 MRO

3.14e-0481002EFO_1001114
DiseaseFamilial hyperinsulinism

INSR ABCC8

3.14e-0481002cv:C3888018
Diseasemultiple system atrophy

MDGA2 PKHD1L1 CDH4

3.41e-04401003EFO_1001050
Diseasecortical thickness

PRTG PLXND1 MINDY2 BMP7 CELSR1 IGF1R PMPCA MRO PAM MICAL3 ULK2 WNK2

3.87e-04111310012EFO_0004840
Diseasetype 2 diabetes mellitus (implicated_via_orthology)

INSR INSRR IGF1R PRKCI

4.57e-041051004DOID:9352 (implicated_via_orthology)
DiseaseGastric Adenocarcinoma

EPHB4 INSR EPHA2

4.83e-04451003C0278701
DiseaseEpilepsy

NEXMIF GRIN2B ABCB1 SYNGAP1

5.26e-041091004C0014544
Diseasekidney cancer (implicated_via_orthology)

POLE LATS1

6.13e-04111002DOID:263 (implicated_via_orthology)
Diseaseinsomnia, bilirubin measurement

UGT1A6 MROH2A

6.13e-04111002EFO_0004570, EFO_0004698
Diseasedevelopmental disorder of mental health (implicated_via_orthology)

GRIN2B PLXND1 SYNGAP1

6.21e-04491003DOID:0060037 (implicated_via_orthology)
Diseaseglucose metabolism measurement, age-related hearing impairment

PCSK5 TOX INSR

7.40e-04521003EFO_0005782, EFO_0009367
DiseasePeripheral Nervous System Diseases

ABCB1 IGF1R PRKCE

8.26e-04541003C4721453
Diseaserenal cell carcinoma (is_marker_for)

INSR BIRC3 ABCB1 BMP7

9.60e-041281004DOID:4450 (is_marker_for)
Diseaseserum gamma-glutamyl transferase measurement

CABP1 UGT1A6 CYP21A2 YES1 IGF1R EPHA2 HACE1 MICAL3 ULK1 SIPA1L2

1.08e-0391410010EFO_0004532
Diseasehepatic encephalopathy (biomarker_via_orthology)

INSR ABCB1

1.16e-03151002DOID:13413 (biomarker_via_orthology)
DiseaseLiver Cirrhosis, Experimental

PRTG HYKK BIRC3 CES2 ABCB1 GSTA3 BMP7 MRO FGR

1.28e-037741009C0023893
Diseaselung non-small cell carcinoma (is_implicated_in)

AMD1 POLE BIRC3 ABCB1

1.30e-031391004DOID:3908 (is_implicated_in)
DiseaseMonogenic diabetes

INSR ABCC8

1.32e-03161002C3888631
Diseasenon-alcoholic fatty liver disease (biomarker_via_orthology)

INSR ABCB1 IGF1R

1.42e-03651003DOID:0080208 (biomarker_via_orthology)
Diseaselow density lipoprotein cholesterol measurement, body fat percentage

DNAH10 UGT1A6

1.50e-03171002EFO_0004611, EFO_0007800
Diseasetype 2 diabetes mellitus (biomarker_via_orthology)

UGT1A6 INSR IGF1R PRKCE

1.60e-031471004DOID:9352 (biomarker_via_orthology)
Diseaseattention deficit hyperactivity disorder, substance abuse, antisocial behaviour measurement

CABP1 TOX ELP1 MDGA2 GRIK1 IGF1R HACE1 SIPA1L2 HPS5

1.61e-038011009EFO_0003888, EFO_0007052, MONDO_0002491
DiseaseAdrenocortical carcinoma

ABCB1 IGF1R

1.68e-03181002C0206686
DiseaseCongenital hernia of foramen of Morgagni

INSR IGF1R

1.87e-03191002C0265699
DiseaseCongenital hernia of foramen of Bochdalek

INSR IGF1R

1.87e-03191002C0265700
Diseaseprostate cancer (is_marker_for)

AMD1 STAT6 BMP7 IGF1R

1.99e-031561004DOID:10283 (is_marker_for)
Diseaseprostate adenocarcinoma (is_implicated_in)

INSR IGF1R

2.08e-03201002DOID:2526 (is_implicated_in)
Diseaseepilepsy (biomarker_via_orthology)

GRIN2B ABCB1

2.29e-03211002DOID:1826 (biomarker_via_orthology)
DiseaseCongenital diaphragmatic hernia

INSR IGF1R

2.29e-03211002C0235833
DiseaseLung diseases

PCSK5 INSR IGF1R

2.39e-03781003C0024115
DiseaseLewy Body Disease

INSR IGF1R

2.51e-03221002C0752347
Diseasecotinine measurement

HYKK CDH4

2.75e-03231002EFO_0007813
DiseaseAllodynia

INSR GRIN2B PRKCE

2.95e-03841003C0458247
DiseaseMechanical Allodynia

INSR GRIN2B PRKCE

2.95e-03841003C2936719
DiseaseHyperalgesia, Secondary

INSR GRIN2B PRKCE

2.95e-03841003C0751212
DiseaseHyperalgesia, Primary

INSR GRIN2B PRKCE

2.95e-03841003C0751211
DiseaseHyperalgesia, Thermal

INSR GRIN2B PRKCE

2.95e-03841003C0751214
DiseaseTactile Allodynia

INSR GRIN2B PRKCE

2.95e-03841003C0751213
DiseaseHyperalgesia

INSR GRIN2B PRKCE

2.95e-03841003C0020429
Diseasefasting blood glucose measurement

GAD2 ELP1 BMP7 IGF1R WNK2

2.98e-032871005EFO_0004465
DiseaseFEV change measurement, response to zileuton

CYP21A2 PRKCE

3.24e-03251002EFO_0005921, EFO_0007676
Diseasecolorectal cancer, hormone replacement therapy

INSR GRIN2B DISP1

3.36e-03881003EFO_0003961, MONDO_0005575
Diseasedescending aortic diameter

UNC45A STAT6 ABCC8

3.36e-03881003EFO_0021788

Protein segments in the cluster

PeptideGeneStartEntry
GMQNSLMMLVDTPDY

COG7

156

P83436
YVMVQDMLSPSPMER

EIF2AK3

1051

Q9NZJ5
MVTMALVDANYEMPG

ACER1

221

Q8TDN7
GLLDGMMTTEAALMY

GRIK1

311

P39086
MESMTYLTAGMLDQP

ACAD9

356

Q9H845
MMNTPVINAAVEMGF

BIRC3

376

Q13489
IAGMYLMMSVDTVIP

PAM

196

P19021
NYGPMSMLEQDSRRM

ATF6

391

P18850
RIDPDSGTMYTMMEL

CELSR1

836

Q9NYQ6
MEPVNMESMGHPEIY

DNAI3

26

Q8IWG1
MFMLDLYNAMAVEEG

BMP7

81

P18075
TMGYMPTEMELIELS

CABP1

256

Q9NZU7
FVAGAMMMPSTVLAY

DISP1

1091

Q96F81
KQDPNYLATMAMDGM

DCAF7

231

P61962
YLATMAMDGMEVVIL

DCAF7

236

P61962
MVPHLETDMMQGGVY

AKAP8L

101

Q9ULX6
GSPMMKAAMYSVEIT

PALM

161

O75781
PLMMLVFGEMTDIFA

ABCB1

66

P08183
MELSCSEAPLYGQMM

ARHGEF28

1

Q8N1W1
PGGAISNMYAMMIAR

GAD2

241

Q05329
VLMFEMMAGRSPFDI

PRKCI

441

P41743
MASVGEPDKLSMVMY

MICAL3

601

Q7RTP6
AMYLMVGIEMEHFPE

TAT

371

P17735
SMPVMILTEFMENGA

EPHB4

686

P54760
DMAAQVAEGMAYMER

FGR

361

P09769
VMDYIPGGDMMSLLI

LATS1

781

O95835
PEDGMAVCMFMQNTL

ECHDC1

126

Q9NTX5
LMYEMMAGQPPFEAD

PRKCE

596

Q02156
GLKEMASSNPVYMEM

HPS5

811

Q9UPZ3
MAPEMDQFYRSTMAI

BAIAP2L2

1

Q6UXY1
SEPMGYMLFNERMLE

CARM1

256

Q86X55
MMDYMLQGVAQPSME

CYP21A2

256

P08686
MAAFSEMGVMPEIAQ

DDX1

1

Q92499
LIDMYTEGMADLNEM

GSTA3

91

Q16772
KMIQMAGEIADGMAY

IGF1R

1111

P08069
GEVPYTTLATRMMMG

GRID2

621

O43424
LYGFGLMDAEAMVME

PCSK5

441

Q92824
PMTVMVYNCAMGSPD

PLXND1

841

Q9Y4D7
QFQEMMADSMFVIPA

CES2

406

O00748
VTMDPSCEVGMAYSM

GLYATL1

221

Q969I3
DNETAVYTLMPMVMA

HACE1

26

Q8IYU2
NSSDMDGEPMYIQMV

NIPBL

1476

Q6KC79
LMQEHMYEPAGLMFA

ELP1

996

O95163
HMAMRNLGTMAYEAP

MRO

66

Q9BYG7
PDAETDQIMMISYMI

POLE

286

Q07864
MIQMAAEIADGMAYL

INSR

1136

P06213
MPDGSMQMESYDGTL

MDGA2

486

Q7Z553
YMPMGASQMSDHVTQ

PRTG

496

Q2VWP7
ECNPMAYVMEKAGGM

FBP1

281

P09467
MCRGIPTYMAEEMQE

GKN1

141

Q9NS71
MYMMIESKSPIQVGG

HYKK

271

A2RU49
DCMRTLGYMPTEMEL

CABP4

156

P57796
MEASLGIQMDEPMAF

CDC7

1

O00311
KPMMIITEYMENGAL

EPHA2

686

P29317
MSELDPAVMDQFYMK

AMD1

181

P17707
ALFRTVAMMVPDYAM

DNAH7

1446

Q8WXX0
PMEVFSIDSMSGRMY

CDH4

216

P55283
LIFIDDMNMPVSDMY

DNAH14

1926

Q0VDD8
MMQTIGQKYCMDPAV

LYG1

71

Q8N1E2
YRAEMDNPEMFDLMP

MCF2

521

P10911
EMIQMAGEIADGMAY

INSRR

1091

P14616
MMQEAMSAFPGIDEA

GET3

131

O43681
MKEAMEIMPETLEYG

DNAH10

116

Q8IVF4
MDDMNMPRVDEYGTQ

DNAH10

2521

Q8IVF4
AQPQMMVVSDVADMF

SEC24C

566

P53992
AMGSTECVLLPMMAY

OR13F1

106

Q8NGS4
MREIPEMEGYMKAEV

MROH2A

131

A6NES4
MMEIITAEQLMEYLG

MINDY2

286

Q8NBR6
EEDFIPFAVLNMMMG

PMPCA

331

Q10713
EYSEENGPLMMQVGM

TAF1L

701

Q8IZX4
GMADVQRFMMASIEP

NEXMIF

1326

Q5QGS0
ECPGMYSEMDVMSTA

SIPA1L2

1416

Q9P2F8
AMGYQPLVTMDDAME

NSDHL

346

Q15738
FIPGSALNGMVEMMD

IARS2

501

Q9NSE4
MAITGIVMMAYADNF

SLC35F4

311

A4IF30
NTMDDQGMTPLMYAC

ABTB2

516

Q8N961
LYMPAGMAFMAAVTS

ABCC8

106

Q09428
VMNMYGDLVMDTVPE

SENP3

406

Q9H4L4
RAVSEMALAMGFMPV

STEAP3

176

Q658P3
VVLRGPSAEMQGYMM

SYNGAP1

746

Q96PV0
PSAEMQGYMMRDLNS

SYNGAP1

751

Q96PV0
LQMPTMVPSYDLGMA

STAT6

661

P42226
VYVMGGVAMSEMRAA

STXBP2

536

Q15833
MSLMLDDQPPMEAQY

TMPRSS5

1

Q9H3S3
PMISGQDEDMLRYMI

TSPYL4

266

Q9UJ04
YMVMEYMPGGDLVNL

ROCK2

166

O75116
DNGMAIFPMIYMPAA

PKHD1L1

3506

Q86WI1
AMMLQPGPQLYDVMD

TNFRSF25

326

Q93038
VAVGTAAEMMLMPYG

RHCG

291

Q9UBD6
GSPMYMAPEVIMSQH

ULK2

176

Q8IYT8
ISMYARAGIDDMSME

TTC7A

141

Q9ULT0
DYPEGIEMASMEMAN

TMC5

291

Q6UXY8
AFGMCMLEMATSEYP

WNK2

381

Q9Y3S1
GVYESICNGVPMVMM

UGT1A6

376

P19224
YATILEMQAMMTFDP

TTC39A

61

Q5SRH9
MTFDPQDILLAGNMM

TTC39A

71

Q5SRH9
DGENMYMSMTEPSQD

TOX

36

O94900
TMYTDIMDPMLNAVQ

UBQLN3

256

Q9H347
MCPPVSMRYEEEGMS

TEX19

1

Q8NA77
MYMAPEVIMSQHYDG

ULK1

186

O75385
AVPMIEGYMFEEHEM

UNC45A

776

Q9H3U1
GMLITGSSVMDMYPL

WDR64

426

B1ANS9
MAAQIADGMAYIERM

YES1

376

P07947
DNMAGVFYMLGAAMA

GRIN2B

816

Q13224