Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	kinase activity	PMS2P1 TNK1 FCSK MET MAST4 CAMK2D CAMK2G MAST2 TRRAP MVK	2.18e-04	764	67	10	GO:0016301
GeneOntologyMolecularFunction	transferase activity, transferring phosphorus-containing groups	PMS2P1 TNK1 FCSK MET MAST4 CAMK2D CAMK2G FHIT MAST2 TRRAP MVK	2.67e-04	938	67	11	GO:0016772
GeneOntologyCellularComponent	calcium- and calmodulin-dependent protein kinase complex	CAMK2D CAMK2G	1.01e-04	5	67	2	GO:0005954
Domain	CaMKII_AD	CAMK2D CAMK2G	6.90e-05	4	64	2	PF08332
Domain	Ca/CaM-dep_prot_kinase-assoc	CAMK2D CAMK2G	6.90e-05	4	64	2	IPR013543
Domain	GHMP_KINASES_ATP	FCSK MVK	6.90e-05	4	64	2	PS00627
Domain	DUF1908	MAST4 MAST2	6.90e-05	4	64	2	PF08926
Domain	-	MMP28 MMP21	6.90e-05	4	64	2	1.10.101.10
Domain	Mevalonate/galactokinase	FCSK MVK	6.90e-05	4	64	2	IPR006206
Domain	GHMP_knse_ATP-bd_CS	FCSK MVK	6.90e-05	4	64	2	IPR006203
Domain	MA_Ser/Thr_Kinase_dom	MAST4 MAST2	6.90e-05	4	64	2	IPR015022
Domain	MAST_pre-PK_dom	MAST4 MAST2	6.90e-05	4	64	2	IPR023142
Domain	-	MAST4 MAST2	6.90e-05	4	64	2	1.20.1480.20
Domain	GHMP_kinase_C_dom	FCSK MVK	1.15e-04	5	64	2	IPR013750
Domain	GHMP_kinases_C	FCSK MVK	1.15e-04	5	64	2	PF08544
Domain	GHMP_kinase_N_dom	FCSK MVK	1.15e-04	5	64	2	IPR006204
Domain	GHMP_kinases_N	FCSK MVK	1.15e-04	5	64	2	PF00288
Domain	-	FCSK MVK	1.15e-04	5	64	2	3.30.70.890
Domain	-	CAMK2D CAMK2G	8.80e-04	13	64	2	3.10.450.50
Domain	NTF2-like_dom	CAMK2D CAMK2G	1.18e-03	15	64	2	IPR032710
Domain	-	PLPPR4 G6PC2	1.71e-03	18	64	2	1.20.144.10
Domain	Pept_M10A_stromelysin-type	MMP28 MMP21	1.71e-03	18	64	2	IPR016293
Domain	acidPPc	PLPPR4 G6PC2	1.71e-03	18	64	2	SM00014
Domain	-	MAST4 MBTPS2 MAST2 LNX1	1.75e-03	150	64	4	2.30.42.10
Domain	PDZ	MAST4 MBTPS2 MAST2 LNX1	1.83e-03	152	64	4	IPR001478
Domain	P_Acid_Pase_2/haloperoxidase	PLPPR4 G6PC2	2.11e-03	20	64	2	IPR000326
Domain	PAP2	PLPPR4 G6PC2	2.11e-03	20	64	2	PF01569
Domain	PG_binding_1	MMP28 MMP21	2.11e-03	20	64	2	PF01471
Domain	Peptidoglycan-bd-like	MMP28 MMP21	2.11e-03	20	64	2	IPR002477
Domain	-	FCSK MVK	2.33e-03	21	64	2	3.30.230.10
Domain	Kinase-like_dom	TNK1 MET MAST4 CAMK2D CAMK2G MAST2 TRRAP	2.48e-03	542	64	7	IPR011009
Domain	Ribosomal_S5_D2-typ_fold_subgr	FCSK MVK	2.55e-03	22	64	2	IPR014721
Domain	Hemopexin-like_dom	MMP28 MMP21	2.79e-03	23	64	2	IPR000585
Domain	Hemopexin-like_repeat	MMP28 MMP21	2.79e-03	23	64	2	IPR018487
Domain	M10A_MMP	MMP28 MMP21	2.79e-03	23	64	2	IPR033739
Domain	Hemopexin	MMP28 MMP21	2.79e-03	23	64	2	PF00045
Domain	HEMOPEXIN	MMP28 MMP21	2.79e-03	23	64	2	PS00024
Domain	-	MMP28 MMP21	2.79e-03	23	64	2	2.110.10.10
Domain	HEMOPEXIN_2	MMP28 MMP21	2.79e-03	23	64	2	PS51642
Domain	HX	MMP28 MMP21	2.79e-03	23	64	2	SM00120
Domain	Pept_M10A	MMP28 MMP21	2.79e-03	23	64	2	IPR021190
Domain	Peptidase_M10	MMP28 MMP21	3.04e-03	24	64	2	PF00413
Domain	ZnMc	MMP28 MMP21	4.42e-03	29	64	2	SM00235
Domain	Peptidase_Metallo	MMP28 MMP21	4.42e-03	29	64	2	IPR006026
Domain	ZINC_PROTEASE	MBTPS2 MMP28 MMP21	4.63e-03	98	64	3	PS00142
Domain	PROTEIN_KINASE_ATP	TNK1 MET MAST4 CAMK2D CAMK2G MAST2	4.80e-03	459	64	6	PS00107
Domain	Sema	MET SEMA3G	5.04e-03	31	64	2	SM00630
Domain	Semap_dom	MET SEMA3G	5.04e-03	31	64	2	IPR001627
Domain	Sema	MET SEMA3G	5.04e-03	31	64	2	PF01403
Domain	SEMA	MET SEMA3G	5.04e-03	31	64	2	PS51004
Domain	PSI	MET SEMA3G	5.37e-03	32	64	2	PF01437
Domain	Plexin_repeat	MET SEMA3G	5.37e-03	32	64	2	IPR002165
Domain	-	TMTC4 PRMT9 TRAPPC8 TRRAP	5.54e-03	207	64	4	1.25.40.10
Domain	Ribosomal_S5_D2-typ_fold	FCSK MVK	6.04e-03	34	64	2	IPR020568
Domain	Prot_kinase_dom	TNK1 MET MAST4 CAMK2D CAMK2G MAST2	6.50e-03	489	64	6	IPR000719
Domain	PROTEIN_KINASE_DOM	TNK1 MET MAST4 CAMK2D CAMK2G MAST2	6.75e-03	493	64	6	PS50011
Pubmed	[PI3K/Akt/Erk signaling pathway mediates neuroprotection of CaMKⅡγ and CaMKⅡδ against ischemic reperfusion injury in mice].	CAMK2D CAMK2G	3.88e-06	2	69	2	38597448
Pubmed	Adipocyte CAMK2 deficiency improves obesity-associated glucose intolerance.	CAMK2D CAMK2G	3.88e-06	2	69	2	34303021
Pubmed	Altered Met receptor phosphorylation and LRP1-mediated uptake in cells lacking carbohydrate-dependent lysosomal targeting.	MET LRP1	3.88e-06	2	69	2	28724630
Pubmed	CaM kinase II regulates cardiac hemoglobin expression through histone phosphorylation upon sympathetic activation.	CAMK2D CAMK2G	3.88e-06	2	69	2	31619570
Pubmed	Ischemic Injury-Induced CaMKIIδ and CaMKIIγ Confer Neuroprotection Through the NF-κB Signaling Pathway.	CAMK2D CAMK2G	3.88e-06	2	69	2	29992531
Pubmed	Ca2+/calmodulin-dependent protein kinase II-γ (CaMKIIγ) negatively regulates vascular smooth muscle cell proliferation and vascular remodeling.	CAMK2D CAMK2G	3.88e-06	2	69	2	26567004
Pubmed	Cardiac CaM Kinase II genes δ and γ contribute to adverse remodeling but redundantly inhibit calcineurin-induced myocardial hypertrophy.	CAMK2D CAMK2G	3.88e-06	2	69	2	25124496
Pubmed	Description of the smallest critical region for Dandy-Walker malformation in chromosome 13 in a girl with a cryptic deletion related to t(6;13)(q23;q32).	ZIC5 ZIC2	3.88e-06	2	69	2	20683983
Pubmed	CaM Kinase II mediates maladaptive post-infarct remodeling and pro-inflammatory chemoattractant signaling but not acute myocardial ischemia/reperfusion injury.	CAMK2D CAMK2G	3.88e-06	2	69	2	25193973
Pubmed	Identification of novel human tumor cell-specific CaMK-II variants.	CAMK2D CAMK2G	1.16e-05	3	69	2	9060999
Pubmed	Cloning and quantitative determination of the human Ca2+/calmodulin-dependent protein kinase II (CaMK II) isoforms in human beta cells.	CAMK2D CAMK2G	1.16e-05	3	69	2	10819240
Pubmed	Crucial role for Ca2(+)/calmodulin-dependent protein kinase-II in regulating diastolic stress of normal and failing hearts via titin phosphorylation.	CAMK2D CAMK2G	1.16e-05	3	69	2	23283722
Pubmed	Calcium/calmodulin kinase II-dependent acetylcholine receptor cycling at the mammalian neuromuscular junction in vivo.	CAMK2D CAMK2G	1.16e-05	3	69	2	20844140
Pubmed	Essentiality of Regulator of G Protein Signaling 6 and Oxidized Ca2+/Calmodulin-Dependent Protein Kinase II in Notch Signaling and Cardiovascular Development.	CAMK2D CAMK2G	1.16e-05	3	69	2	29079565
Pubmed	Calcium/calmodulin-dependent protein kinase II couples Wnt signaling with histone deacetylase 4 and mediates dishevelled-induced cardiomyopathy.	CAMK2D CAMK2G	1.16e-05	3	69	2	25489064
Pubmed	Expression of ZIC family genes in meningiomas and other brain tumors.	ZIC5 ZIC2	1.16e-05	3	69	2	20199689
Pubmed	CaMKII Serine 280 O-GlcNAcylation Links Diabetic Hyperglycemia to Proarrhythmia.	CAMK2D CAMK2G	1.16e-05	3	69	2	33926209
Pubmed	Phosphorylation of Serine 235 of the Hepatitis C Virus Non-Structural Protein NS5A by Multiple Kinases.	CAMK2D CAMK2G	1.16e-05	3	69	2	27875595
Pubmed	Expression of MMP-10, MMP-21, MMP-26, and MMP-28 in Merkel cell carcinoma.	MMP28 MMP21	2.32e-05	4	69	2	19921252
Pubmed	SUMOylation Potentiates ZIC Protein Activity to Influence Murine Neural Crest Cell Specification.	ZIC5 ZIC2	2.32e-05	4	69	2	34638777
Pubmed	Developmental expression of the CaM kinase II isoforms: ubiquitous gamma- and delta-CaM kinase II are the early isoforms and most abundant in the developing nervous system.	CAMK2D CAMK2G	2.32e-05	4	69	2	10381553
Pubmed	Cadmium activates CaMK-II and initiates CaMK-II-dependent apoptosis in mesangial cells.	CAMK2D CAMK2G	2.32e-05	4	69	2	17367784
Pubmed	[Molecular mechanisms of the intracellular localizations of Ca2+/calmodulin-dependent protein kinase II isoforms, and their physiological functions].	CAMK2D CAMK2G	2.32e-05	4	69	2	11889801
Pubmed	Novel genes differentially expressed in cortical regions during late neurogenesis.	ZIC5 TBR1 ATP13A2	2.36e-05	28	69	3	17614941
Pubmed	Molecular design of hypothalamus development.	SLC6A3 ZIC5 TBR1	3.23e-05	31	69	3	32499648
Pubmed	Calmodulin kinase II attenuation of gene transcription by preventing cAMP response element-binding protein (CREB) dimerization and binding of the CREB-binding protein.	CAMK2D CAMK2G	3.86e-05	5	69	2	11013247
Pubmed	Alpha-kinase anchoring protein alphaKAP interacts with SERCA2A to spatially position Ca2+/calmodulin-dependent protein kinase II and modulate phospholamban phosphorylation.	CAMK2D CAMK2G	3.86e-05	5	69	2	19671701
Pubmed	Human immunodeficiency virus-1 Tat protein increases the number of inhibitory synapses between hippocampal neurons in culture.	CAMK2G LRP1	3.86e-05	5	69	2	24198379
Pubmed	Ca2+/calmodulin-dependent protein kinase IIdelta and protein kinase D overexpression reinforce the histone deacetylase 5 redistribution in heart failure.	CAMK2D CAMK2G	3.86e-05	5	69	2	18218981
Pubmed	Aberrant calcium/calmodulin-dependent protein kinase II (CaMKII) activity is associated with abnormal dendritic spine morphology in the ATRX mutant mouse brain.	CAMK2D CAMK2G	3.86e-05	5	69	2	21209221
Pubmed	Comparative analyses of the three-dimensional structures and enzymatic properties of alpha, beta, gamma and delta isoforms of Ca2+-calmodulin-dependent protein kinase II.	CAMK2D CAMK2G	3.86e-05	5	69	2	14722083
Pubmed	Transition from reversible to persistent binding of CaMKII to postsynaptic sites and NR2B.	CAMK2D CAMK2G	3.86e-05	5	69	2	16436603
Pubmed	Epac2 mediates cardiac β1-adrenergic-dependent sarcoplasmic reticulum Ca2+ leak and arrhythmia.	RAPGEF3 CAMK2D	3.86e-05	5	69	2	23363625
Pubmed	Multiple kinases regulate mafA expression in the pancreatic beta cell line MIN6.	CAMK2D CAMK2G	5.79e-05	6	69	2	18948074
Pubmed	Multivalent interactions of calcium/calmodulin-dependent protein kinase II with the postsynaptic density proteins NR2B, densin-180, and alpha-actinin-2.	CAMK2D CAMK2G	5.79e-05	6	69	2	16120608
Pubmed	Requirement of Ca2+ and CaMKII for Stat1 Ser-727 phosphorylation in response to IFN-gamma.	CAMK2D CAMK2G	5.79e-05	6	69	2	11972023
Pubmed	Molecular properties of Zic4 and Zic5 proteins: functional diversity within Zic family.	ZIC5 ZIC2	5.79e-05	6	69	2	15465018
Pubmed	Genome-wide meta-analysis of myopia and hyperopia provides evidence for replication of 11 loci.	ZIC5 ZIC2	8.09e-05	7	69	2	25233373
Pubmed	ERK1/2 inhibition promotes robust myotube growth via CaMKII activation resulting in myoblast-to-myotube fusion.	CAMK2D CAMK2G	8.09e-05	7	69	2	34932950
Pubmed	Zic2 Controls the Migration of Specific Neuronal Populations in the Developing Forebrain.	TBR1 ZIC2	8.09e-05	7	69	2	26269635
Pubmed	Methyl-CpG binding domain proteins and their involvement in the regulation of the MAGE-A1, MAGE-A2, MAGE-A3, and MAGE-A12 gene promoters.	MAGEA2 MAGEA12	8.09e-05	7	69	2	17634428
Pubmed	A genome-wide association study identifies novel and functionally related susceptibility Loci for Kawasaki disease.	CAMK2D LNX1	8.09e-05	7	69	2	19132087
Pubmed	Rad and Rad-related GTPases interact with calmodulin and calmodulin-dependent protein kinase II.	CAMK2D CAMK2G	8.09e-05	7	69	2	9115241
Pubmed	Expression of melanoma-associated antigens in oral squamous cell carcinoma.	MAGEA2 MAGEA12	8.09e-05	7	69	2	18197853
Pubmed	Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition.	TNK1 ZBTB49 CAMK2D CAMK2G MAST2 LNX1	9.77e-05	372	69	6	22939624
Pubmed	Ca(2+)/CaM-dependent kinases: from activation to function.	CAMK2D CAMK2G	1.08e-04	8	69	2	11264466
Pubmed	Structure of the CaMKIIdelta/calmodulin complex reveals the molecular mechanism of CaMKII kinase activation.	CAMK2D CAMK2G	1.08e-04	8	69	2	20668654
Pubmed	Calcineurin-independent regulation of plasma membrane Ca2+ ATPase-4 in the vascular smooth muscle cell cycle.	CAMK2D CAMK2G	1.38e-04	9	69	2	12660151
Pubmed	Mouse Zic5 deficiency results in neural tube defects and hypoplasia of cephalic neural crest derivatives.	ZIC5 ZIC2	1.73e-04	10	69	2	15136147
Pubmed	CD spectra show the relational style between Zic-, Gli-, Glis-zinc finger protein and DNA.	ZIC5 ZIC2	1.73e-04	10	69	2	18298960
Pubmed	CaMKII Signaling Stimulates Mef2c Activity In Vitro but Only Minimally Affects Murine Long Bone Development in vivo.	CAMK2D CAMK2G	1.73e-04	10	69	2	28361052
Pubmed	The presence and activation of two essential transcription factors (cAMP response element-binding protein and cAMP-dependent transcription factor ATF1) in the two-cell mouse embryo.	CAMK2D CAMK2G	1.73e-04	10	69	2	19776387
Pubmed	Spatiotemporal expression of Zic genes during vertebrate inner ear development.	ZIC5 ZIC2	1.73e-04	10	69	2	23606270
Pubmed	Characterization of Opr deficiency in mouse brain: subtle defects in dorsomedial telencephalon and medioventral forebrain.	ZIC5 ZIC2	1.73e-04	10	69	2	15736266
Pubmed	Notch Activation by Shootin1 Opposing Activities on 2 Ubiquitin Ligases.	TBR1 LNX1	2.11e-04	11	69	2	28981589
Pubmed	Fibroblast growth factor 8 organizes the neocortical area map and regulates sensory map topography.	TBR1 ZIC2	2.11e-04	11	69	2	22623663
Pubmed	PCP4 (PEP19) overexpression induces premature neuronal differentiation associated with Ca(2+) /calmodulin-dependent kinase II-δ activation in mouse models of Down syndrome.	CAMK2D CAMK2G	2.11e-04	11	69	2	21491429
Pubmed	Multiple and cooperative phosphorylation events regulate the CREM activator function.	CAMK2D CAMK2G	2.11e-04	11	69	2	8404858
Pubmed	Expression of Ca2+/calmodulin-dependent protein kinase types II and IV, and reduced DNA synthesis due to the Ca2+/calmodulin-dependent protein kinase inhibitor KN-62 (1-[N,O-bis(5-isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4-phenyl piperazine) in small cell lung carcinoma.	CAMK2D CAMK2G	2.53e-04	12	69	2	8615909
Pubmed	Semaphorin 3F is a bifunctional guidance cue for dopaminergic axons and controls their fasciculation, channeling, rostral growth, and intracortical targeting.	SEMA3G TBR1	2.53e-04	12	69	2	19812329
Pubmed	Developmental rearrangements of cortical glutamate-NMDA receptor binding sites in late human gestation.	CAMK2D CAMK2G	2.53e-04	12	69	2	8665664
Pubmed	Specification of spatial identities of cerebellar neuron progenitors by ptf1a and atoh1 for proper production of GABAergic and glutamatergic neurons.	TBR1 ZIC2	2.53e-04	12	69	2	24695699
Pubmed	Activation of peripheral NMDA receptors contributes to human pain and rat afferent discharges evoked by injection of glutamate into the masseter muscle.	CAMK2D CAMK2G	2.53e-04	12	69	2	12815021
Pubmed	Receptor-mediated clustering of FIP200 bypasses the role of LC3 lipidation in autophagy.	PPIG NUDT21 NOM1 MTG2 UHRF1 HEATR1	2.87e-04	454	69	6	33226137
Pubmed	hnRNP U protein is required for normal pre-mRNA splicing and postnatal heart development and function.	CAMK2D CAMK2G	2.98e-04	13	69	2	26039991
Pubmed	The melanoma antigen gene (MAGE) family is clustered in the chromosomal band Xq28.	MAGEA2 MAGEA12	3.48e-04	14	69	2	8575766
Pubmed	Ras-specific exchange factor GRF: oligomerization through its Dbl homology domain and calcium-dependent activation of Raf.	CAMK2D CAMK2G	3.48e-04	14	69	2	10373510
Pubmed	Hepatitis B Virus HBx Protein Mediates the Degradation of Host Restriction Factors through the Cullin 4 DDB1 E3 Ubiquitin Ligase Complex.	FCSK EPPK1 CAMK2D CAMK2G TRAPPC8	3.51e-04	304	69	5	32235678
Pubmed	The NMDA receptor is coupled to the ERK pathway by a direct interaction between NR2B and RasGRF1.	CAMK2D CAMK2G	4.01e-04	15	69	2	14622581
Pubmed	Adjacent asparagines in the NR2-subunit of the NMDA receptor channel control the voltage-dependent block by extracellular Mg2+.	CAMK2D CAMK2G	4.01e-04	15	69	2	9481670
Pubmed	Structure, chromosomal localization, and expression of 12 genes of the MAGE family.	MAGEA2 MAGEA12	4.01e-04	15	69	2	7927540
Pubmed	SMC5/6 is required for replication fork stability and faithful chromosome segregation during neurogenesis.	TBR1 SMC5	4.57e-04	16	69	2	33200984
Pubmed	Loss of Uhrf1 in neural stem cells leads to activation of retroviral elements and delayed neurodegeneration.	UHRF1 TBR1	4.57e-04	16	69	2	27798843
Pubmed	Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry.	MET CAMK2D CAMK2G	5.11e-04	78	69	3	17192257
Pubmed	Motor protein-dependent transport of AMPA receptors into spines during long-term potentiation.	CAMK2D CAMK2G	5.81e-04	18	69	2	18311135
Pubmed	Arl13b-regulated cilia activities are essential for polarized radial glial scaffold formation.	SLC6A3 TBR1	5.81e-04	18	69	2	23817546
Pubmed	Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations.	MAGEA2 ZBTB49 MAGEA12 ZNF792 NUDT21 CAMK2D FHIT LNX1 TRIM59 MVK	6.42e-04	1477	69	10	31515488
Pubmed	Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.	TMEM177 ZIC5 RAPGEF3 MARF1 UHRF1 HEATR1 SEMA3G MAST2 MNT	6.49e-04	1215	69	9	15146197
Pubmed	Identification of early-responsive genes correlated to valproic acid-induced neural tube defects in mice.	ZIC5 ZIC2	6.49e-04	19	69	2	15799026
Pubmed	Sim1-expressing cells illuminate the origin and course of migration of the nucleus of the lateral olfactory tract in the mouse amygdala.	TBR1 ZIC2	6.49e-04	19	69	2	33492553
Pubmed	Association studies of 23 positional/functional candidate genes on chromosome 10 in late-onset Alzheimer's disease.	SLC18A3 CAMK2G	6.49e-04	19	69	2	17373700
Pubmed	Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains.	NUDT21 NOM1 UHRF1 HEATR1 TBR1 TRRAP	6.67e-04	533	69	6	30554943
Pubmed	Functional interactions between matrix metalloproteinases and glycosaminoglycans.	MMP28 MMP21	8.73e-04	22	69	2	23421805
Pubmed	Comparative genome sequence analysis of the Bpa/Str region in mouse and Man.	MAGEA2 MAGEA12	8.73e-04	22	69	2	10854409
Pubmed	Zic deficiency in the cortical marginal zone and meninges results in cortical lamination defects resembling those in type II lissencephaly.	TBR1 ZIC2	8.73e-04	22	69	2	18448648
Pubmed	Central roles of the roof plate in telencephalic development and holoprosencephaly.	TBR1 ZIC2	8.73e-04	22	69	2	16855091
Pubmed	Lhx2 regulates the development of the forebrain hem system.	TBR1 ZIC2	8.73e-04	22	69	2	23307637
Pubmed	Sidekick 2 directs formation of a retinal circuit that detects differential motion.	SLC6A3 SLC18A3	9.55e-04	23	69	2	26287463
Pubmed	Large-scale mapping of human protein-protein interactions by mass spectrometry.	MET PPIG EPPK1 NUDT21 CAMK2D NOM1 HEATR1 MAST2 TRRAP	9.59e-04	1284	69	9	17353931
Pubmed	H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.	PPIG ZIC5 NUDT21 NOM1 SMU1 UHRF1 HEATR1 TRRAP MNT	1.01e-03	1294	69	9	30804502
Pubmed	The Tumor Suppressor CIC Directly Regulates MAPK Pathway Genes via Histone Deacetylation.	EPPK1 ZIC5 NOM1 SMU1 ACAP2 ZIC2	1.06e-03	583	69	6	29844126
Pubmed	Zic1 and Zic3 regulate medial forebrain development through expansion of neuronal progenitors.	TBR1 ZIC2	1.13e-03	25	69	2	17507568
Pubmed	Functional genomics identifies therapeutic targets for MYC-driven cancer.	CAMK2D CAMK2G TRRAP	1.15e-03	103	69	3	22623531
Pubmed	Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism.	ZBTB49 MBTPS2 MRPS12 NUDT21 CAMK2G HEATR1 SMC5 TRRAP MNT	1.21e-03	1327	69	9	32694731
Pubmed	Ca2+ homeostasis maintained by TMCO1 underlies corpus callosum development via ERK signaling.	TBR1 ZIC2	1.22e-03	26	69	2	35927240
Pubmed	CLEC16A interacts with retromer and TRIM27, and its loss impairs endosomal trafficking and neurodevelopment.	FCSK CAMK2D NOM1 CAMK2G MTG2 HEATR1	1.29e-03	606	69	6	36538041
Pubmed	Antiviral inhibition targeting the HCMV kinase pUL97 requires pUL27-dependent degradation of Tip60 acetyltransferase and cell-cycle arrest.	NUDT21 TRRAP	1.32e-03	27	69	2	21320693
Pubmed	Integrative genomic analysis of early neurogenesis reveals a temporal genetic program for differentiation and specification of preplate and Cajal-Retzius neurons.	TBR1 ZIC2	1.32e-03	27	69	2	33760820
Pubmed	Parkinson Disease Overview	SLC6A3 ATP13A2	1.32e-03	27	69	2	20301402
Pubmed	LHX2 is necessary for the maintenance of optic identity and for the progression of optic morphogenesis.	TBR1 ZIC2	1.42e-03	28	69	2	23595746
Cytoband	Ensembl 112 genes in cytogenetic band chr13q32	TMTC4 ZIC5 ZIC2	4.20e-04	96	69	3	chr13q32
Cytoband	13q32.3	TMTC4 ZIC5	5.52e-04	23	69	2	13q32.3
ToppCell	3'-Distal_airway-Epithelial-Epithelial_transtional-epithelial_cell_of_lung-Transitional_Club-AT2-Transitional_Club-AT2_L.0.4.1.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	MET PGLYRP4 MAST4 MACROD2 FREM3	6.90e-06	171	69	5	d5960b40ad5b87aaa00c93a6b31cdf41cc4f1375
ToppCell	3'-Distal_airway-Epithelial-Epithelial_transtional-epithelial_cell_of_lung-Transitional_Club-AT2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	MET PGLYRP4 MAST4 MACROD2 FREM3	6.90e-06	171	69	5	fd59ac4a39748840b2ee1c930ea475433ff61485
ToppCell	3'-Distal_airway-Epithelial-Epithelial_transtional-epithelial_cell_of_lung\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	MET PGLYRP4 MAST4 MACROD2 FREM3	6.90e-06	171	69	5	d382430e5cdd0f2aac4fc093d8fe8d66efb4629b
ToppCell	3'-Distal_airway-Epithelial-Epithelial_transtional\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	MET PGLYRP4 MAST4 MACROD2 FREM3	6.90e-06	171	69	5	4347e6f62c04ea43299893ad4b79719049009a56
ToppCell	368C-Lymphocytic-NK_cells-Proliferating_NK_cell\|368C / Donor, Lineage, Cell class and subclass (all cells)	MRPS12 MACROD2 UHRF1 ZNF653 TRIM59	1.12e-05	189	69	5	31d34bc75d4457fca197e1766922e987dbd5f8a9
ToppCell	368C-Lymphocytic-NK_cells-Proliferating_NK_cell\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	MRPS12 MACROD2 UHRF1 ZNF653 TRIM59	1.24e-05	193	69	5	5f5904cec8b2967154ef2eab3c48f51df53aca4a
ToppCell	Sepsis-URO-Lymphocyte-T/NK-dn_T\|URO / Disease, condition lineage and cell class	ZNF573 ASMTL CAMK2G MACROD2 GRPEL2	1.47e-05	200	69	5	04ea6381b93a5d8bbeda4d71c788d7fbac6d40bc
Disease	Keratosis pilaris decalvans	MBTPS2 LRP1	1.39e-05	3	64	2	C0343057
Disease	Gilles de la Tourette syndrome (implicated_via_orthology)	SLC6A3 MET	2.77e-05	4	64	2	DOID:11119 (implicated_via_orthology)
Disease	upper aerodigestive tract neoplasm	HEATR1 FHIT SMC5 LNX1 MVK	1.97e-04	246	64	5	EFO_0004284
Disease	high grade glioma (biomarker_via_orthology)	SLC6A3 MET	4.77e-04	15	64	2	DOID:3070 (biomarker_via_orthology)
Disease	cervical artery dissection	LRP1 LNX1	6.17e-04	17	64	2	EFO_1000059
Disease	sensorineural hearing loss (implicated_via_orthology)	MRPS12 LNX1	7.73e-04	19	64	2	DOID:10003 (implicated_via_orthology)
Disease	Liver carcinoma	MET MBTPS2 ZIC5 UHRF1 MVK ZIC2	8.06e-04	507	64	6	C2239176
Disease	antiphospholipid antibody measurement	MACROD2 ZNF653	1.35e-03	25	64	2	EFO_0005200
Disease	age at first sexual intercourse measurement	MET MACROD2 UHRF1 FHIT SMC5	1.46e-03	383	64	5	EFO_0009749
Disease	Iniencephaly	ZIC5 ZIC2	1.69e-03	28	64	2	C0152234
Disease	Tethered Cord Syndrome	ZIC5 ZIC2	1.69e-03	28	64	2	C0080218
Disease	Spinal Cord Myelodysplasia	ZIC5 ZIC2	1.69e-03	28	64	2	C0344479
Disease	Exencephaly	ZIC5 ZIC2	1.69e-03	28	64	2	C0266453
Disease	Neurenteric Cyst	ZIC5 ZIC2	1.69e-03	28	64	2	C0027806
Disease	Acrania	ZIC5 ZIC2	1.69e-03	28	64	2	C0702169
Disease	Diastematomyelia	ZIC5 ZIC2	1.69e-03	28	64	2	C0011999
Disease	Craniorachischisis	ZIC5 ZIC2	1.81e-03	29	64	2	C0152426
Disease	Neural Tube Defects	ZIC5 ZIC2	1.94e-03	30	64	2	C0027794
Disease	Ovarian Mucinous Adenocarcinoma	MAST2 TRRAP	2.07e-03	31	64	2	C1335167
Disease	Polydactyly	EVC2 MBTPS2 BBS10	2.12e-03	117	64	3	C0152427

Protein segments in the cluster

Peptide	Gene	Start	Entry
HLGQAVHVSGPIFVL	TMEM62	361	Q0P6H9
HHRVGIKDIAGIHLP	PRMT9	316	Q6P2P2
GTTGAHHHAQEPVVI	CCDC28A-AS1	91	A0A096LPI5
DVILHVLPLHHVHGV	ACSF3	236	Q4G176
VLPLHHVHGVVNALL	ACSF3	241	Q4G176
GPLHHATVLGHTGQV	ACAP2	676	Q15057
PVPAVGIGTVHLHQH	DHTKD1	896	Q96HY7
GPVHGLIEQHEDALH	BBS10	401	Q8TAM1
RFGGKTIPHHIHILV	OR52Z1P	246	P0C646
VLHHTLKIGGEPHIS	MAGEA2	286	P43356
VLHHLLKISGGPHIS	MAGEA12	286	P43365
AVVQGLEQPHGLVVH	LRP1	1696	Q07954
LHGFHQVQVVHLGGV	ASMTL	596	O95671
AVHEIGHVLGLPHTY	MMP21	281	Q8N119
VNVLVIHHVPGLECH	PGLYRP4	76	Q96LB8
EENVTVLPHHGLHAA	EVC2	286	Q86UK5
VGGSETPLVHIIIQH	LNX1	291	Q8TBB1
ITVHPATLNHVAHLG	MNT	491	Q99583
ATVHGLIVSGAHRPH	MFSD2B	196	A6NFX1
VHVGEPVHAGGLHTE	PMS2P1	56	A4D2B8
FVGHNIPNHIHIIVA	OR52N2	266	Q8NGI0
HEHELICHVPAGVGV	GRPEL2	176	Q8TAA5
TPHLDGHHVVFGQVI	PPIG	131	Q13427
FLVVNGHGHLVTPTI	OPN3	276	Q9H1Y3
GSVLQHCHLQGPIHI	FCSK	381	Q8N0W3
EHLIIVHATHPERGQ	ATP13A2	771	Q9NQ11
PEAGQTVKHVHVHVL	FHIT	86	P49789
IATHFPHQVILGVIG	G6PC2	171	Q9NQR9
EHQQGHLRLVVPTHG	MARF1	666	Q9Y4F3
ISGVVHEIGHGIAAI	MBTPS2	166	O43462
LITHVNGEPVHGLVH	MAST2	1156	Q6P0Q8
HINGEPVHGLVHTEV	MAST4	1196	O15021
LPHLVVSIIHHVTGE	HEATR1	351	Q9H583
EGVLIVHEHRLPHVL	NUDT21	81	O43809
HTTILNPHVHVIGED	CAMK2G	491	Q13555
HTIILNPHVHLVGDD	CAMK2D	411	Q13557
VVLAHEIGHTLGLTH	MMP28	236	Q9H239
VIHTVGPIARGHING	MACROD2	141	A1Z1Q3
HLEVSDGVHHIPITI	FREM3	916	P0C091
DGVHHIPITIPISVH	FREM3	921	P0C091
PIQNVILHEHHIFLG	MET	51	P08581
PIVAGHIVHSLGFEQ	SLC18A3	436	Q16572
HSGGSELVLHDHPII	TBR1	26	Q16650
LIQEHGLHGIGETVH	LINC00869	246	P0C866
VATGGVIDPQHHHRL	EPPK1	2011	P58107
HQHGSHGGLDIVIIE	SEMG1	426	P04279
PHVGIVHYEGHLQIA	MTG2	261	Q9H4K7
VSILHHTVGIEVGAH	NOM1	426	Q5C9Z4
PGEGHTLQEHQIVLV	MRPS12	96	O15235
HHHGITTIRVTPVEG	PLPPR4	696	Q7Z2D5
GFHPVGFHVVNILLH	TMTC4	101	Q5T4D3
IHQVELIHYVLGPQH	RAPGEF3	681	O95398
LITQEGVHIPFDVHH	ZNF653	236	Q96CK0
ILHLAEHDGTHPEQG	ZNF749	96	O43361
SHIVQHERIHTGGKP	ZNF573	231	Q86YE8
DVIGIAHHPHQNLIA	SMU1	486	Q2TAY7
PGKVILHGEHAVVHG	MVK	11	Q03426
VLHLHQSHGIDDLGP	SLC6A3	221	Q01959
VSESGVHRPHVAGIH	UHRF1	436	Q96T88
EHPHVLRLHGLVLGQ	TNK1	176	Q13470
SLIQHQIVHTGERPH	ZNF792	436	Q3KQV3
LFPHHIGELHILGVV	TRAPPC8	826	Q9Y2L5
ITVGHRGEHVLHLEP	SEMA3G	146	Q9NS98
VQRHIIIHSGEKPHL	ZBTB49	466	Q6ZSB9
TQLHELTPHHQSGGE	SMC5	981	Q8IY18
INTNHPVVIHGHTVD	TMEM177	116	Q53S58
AHLQAEIHTGSHVPL	ZP3	196	P21754
VEEGHTVPQLVHILH	TRRAP	1951	Q9Y4A5
LTIGQHHGHPIDDLQ	TRIM59	121	Q8IWR1
HELVTHVSVEHVGGP	ZIC2	281	O95409
LVNHVTVEHVGGPEQ	ZIC5	441	Q96T25