Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	G protein-coupled receptor activity	OR2T8 OR2T33 OR1B1 OR51B6 FFAR3 GPR42 OR52N5 MC5R OR2T12	6.38e-04	884	55	9	GO:0004930
GeneOntologyMolecularFunction	microtubule motor activity	KIF21B DNHD1 DNAH1	9.50e-04	70	55	3	GO:0003777
GeneOntologyMolecularFunction	transmembrane signaling receptor activity	OR2T8 OR2T33 OR1B1 OR51B6 FFAR3 GPR42 OR52N5 MC5R GRIK4 OR2T12 IL9R	9.98e-04	1353	55	11	GO:0004888
GeneOntologyMolecularFunction	minus-end-directed microtubule motor activity	DNHD1 DNAH1	1.11e-03	18	55	2	GO:0008569
GeneOntologyMolecularFunction	oxidoreductase activity, acting on metal ions	CYBRD1 CP	1.11e-03	18	55	2	GO:0016722
GeneOntologyMolecularFunction	olfactory receptor activity	OR2T8 OR2T33 OR1B1 OR51B6 OR52N5 OR2T12	1.16e-03	431	55	6	GO:0004984
GeneOntologyMolecularFunction	S-adenosyl-L-methionine binding	SETD6 TSR3	1.82e-03	23	55	2	GO:1904047
GeneOntologyMolecularFunction	dynein light intermediate chain binding	DNHD1 DNAH1	2.69e-03	28	55	2	GO:0051959
GeneOntologyBiologicalProcess	positive regulation of acute inflammatory response to non-antigenic stimulus	FFAR3 GPR42	1.94e-05	3	53	2	GO:0002879
GeneOntologyBiologicalProcess	regulation of acute inflammatory response to non-antigenic stimulus	FFAR3 GPR42	3.87e-05	4	53	2	GO:0002877
GeneOntologyBiologicalProcess	insulin receptor signaling pathway	GPLD1 PIK3CA FFAR3 GPR42 SOS2	4.97e-05	156	53	5	GO:0008286
GeneOntologyBiologicalProcess	positive regulation of microtubule binding	PPP2CA PPP2CB	6.45e-05	5	53	2	GO:1904528
GeneOntologyBiologicalProcess	acute inflammatory response to non-antigenic stimulus	FFAR3 GPR42	6.45e-05	5	53	2	GO:0002525
GeneOntologyBiologicalProcess	response to metal ion	GPLD1 PPP2CA PPP2CB CYBRD1 CP TERT RASAL1	8.81e-05	415	53	7	GO:0010038
GeneOntologyBiologicalProcess	positive regulation of neuronal action potential	FFAR3 GPR42	9.65e-05	6	53	2	GO:1904457
GeneOntologyBiologicalProcess	regulation of microtubule binding	PPP2CA PPP2CB	2.31e-04	9	53	2	GO:1904526
GeneOntologyBiologicalProcess	regulation of heart rate by chemical signal	FFAR3 GPR42	2.31e-04	9	53	2	GO:0003062
MousePheno	abnormal sympathetic neuron innervation pattern	FFAR3 GPR42	2.64e-05	3	42	2	MP:0009284
MousePheno	abnormal sympathetic neuron physiology	FFAR3 GPR42	5.27e-05	4	42	2	MP:0009253
Domain	GPR40-rel_orph	FFAR3 GPR42	4.55e-05	4	52	2	IPR013312
Domain	7tm_1	OR2T8 OR2T33 OR1B1 OR51B6 FFAR3 GPR42 OR52N5 MC5R OR2T12	9.33e-05	677	52	9	PF00001
Domain	G_PROTEIN_RECEP_F1_1	OR2T8 OR2T33 OR1B1 OR51B6 FFAR3 GPR42 OR52N5 MC5R OR2T12	1.02e-04	685	52	9	PS00237
Domain	G_PROTEIN_RECEP_F1_2	OR2T8 OR2T33 OR1B1 OR51B6 FFAR3 GPR42 OR52N5 MC5R OR2T12	1.09e-04	691	52	9	PS50262
Domain	GPCR_Rhodpsn	OR2T8 OR2T33 OR1B1 OR51B6 FFAR3 GPR42 OR52N5 MC5R OR2T12	1.10e-04	692	52	9	IPR000276
Domain	GPCR_Rhodpsn_7TM	OR2T8 OR2T33 OR1B1 OR51B6 FFAR3 OR52N5 MC5R OR2T12	4.90e-04	670	52	8	IPR017452
Domain	Ser/Thr-sp_prot-phosphatase	PPP2CA PPP2CB	5.82e-04	13	52	2	IPR006186
Domain	SER_THR_PHOSPHATASE	PPP2CA PPP2CB	5.82e-04	13	52	2	PS00125
Domain	PP2Ac	PPP2CA PPP2CB	5.82e-04	13	52	2	SM00156
Domain	Dynein_HC_stalk	DNHD1 DNAH1	6.77e-04	14	52	2	IPR024743
Domain	Dynein_heavy_dom-2	DNHD1 DNAH1	6.77e-04	14	52	2	IPR013602
Domain	DHC_N2	DNHD1 DNAH1	6.77e-04	14	52	2	PF08393
Domain	MT	DNHD1 DNAH1	6.77e-04	14	52	2	PF12777
Domain	Olfact_rcpt	OR2T8 OR2T33 OR1B1 OR51B6 OR52N5 OR2T12	7.51e-04	393	52	6	IPR000725
Domain	DHC_fam	DNHD1 DNAH1	7.80e-04	15	52	2	IPR026983
Domain	Dynein_heavy_dom	DNHD1 DNAH1	7.80e-04	15	52	2	IPR004273
Domain	Dynein_heavy	DNHD1 DNAH1	7.80e-04	15	52	2	PF03028
Domain	Calcineurin-like_PHP_ApaH	PPP2CA PPP2CB	2.74e-03	28	52	2	IPR004843
Domain	Metallophos	PPP2CA PPP2CB	2.74e-03	28	52	2	PF00149
Domain	Metallo-depent_PP-like	PPP2CA PPP2CB	3.15e-03	30	52	2	IPR029052
Domain	-	PPP2CA PPP2CB	3.15e-03	30	52	2	3.60.21.10
Pathway	WP_GLYCEROPHOSPHOLIPID_BIOSYNTHETIC_PATHWAY	PIK3CA PTDSS1 AGPS	1.24e-04	30	46	3	M39592
Pathway	REACTOME_INTERLEUKIN_2_FAMILY_SIGNALING	PIK3CA IL9R SOS2	1.98e-04	35	46	3	MM15144
Pathway	REACTOME_PP2A_MEDIATED_DEPHOSPHORYLATION_OF_KEY_METABOLIC_FACTORS	PPP2CA PPP2CB	2.16e-04	7	46	2	M26992
Pathway	REACTOME_SIGNALING_BY_FGFR3	PPP2CA PPP2CB PIK3CA	2.74e-04	39	46	3	MM15257
Pathway	REACTOME_SIGNALING_BY_FGFR3	PPP2CA PPP2CB PIK3CA	2.95e-04	40	46	3	M27532
Pathway	REACTOME_SIGNALING_BY_FGFR4	PPP2CA PPP2CB PIK3CA	2.95e-04	40	46	3	MM15258
Pathway	REACTOME_SIGNALING_BY_FGFR4	PPP2CA PPP2CB PIK3CA	3.18e-04	41	46	3	M27533
Pathway	REACTOME_INTERLEUKIN_2_FAMILY_SIGNALING	PIK3CA IL9R SOS2	3.92e-04	44	46	3	M1012
Pathway	REACTOME_MASTL_FACILITATES_MITOTIC_PROGRESSION	PPP2CA PPP2CB	4.61e-04	10	46	2	M27176
Pathway	REACTOME_INHIBITION_OF_REPLICATION_INITIATION_OF_DAMAGED_DNA_BY_RB1_E2F1	PPP2CA PPP2CB	4.61e-04	10	46	2	MM14509
Pathway	REACTOME_SIGNALING_BY_FGFR1	PPP2CA PPP2CB PIK3CA	5.72e-04	50	46	3	MM15255
Pathway	REACTOME_SIGNALING_BY_FGFR1	PPP2CA PPP2CB PIK3CA	6.43e-04	52	46	3	M27530
Pathway	REACTOME_REGULATION_OF_GLYCOLYSIS_BY_FRUCTOSE_2_6_BISPHOSPHATE_METABOLISM	PPP2CA PPP2CB	6.73e-04	12	46	2	M27950
Pathway	WP_PI3KAKT_SIGNALING	PPP2CA PPP2CB COL9A1 G6PC3 PIK3CA SOS2	7.70e-04	339	46	6	M39736
Pathway	REACTOME_ERKS_ARE_INACTIVATED	PPP2CA PPP2CB	7.94e-04	13	46	2	MM14811
Pathway	REACTOME_ERKS_ARE_INACTIVATED	PPP2CA PPP2CB	7.94e-04	13	46	2	M8410
Pathway	REACTOME_INHIBITION_OF_REPLICATION_INITIATION_OF_DAMAGED_DNA_BY_RB1_E2F1	PPP2CA PPP2CB	7.94e-04	13	46	2	M1015
Pathway	WP_DOPAMINE_METABOLISM	PPP2CA PPP2CB	7.94e-04	13	46	2	M39622
Pathway	BIOCARTA_ACH_PATHWAY	PIK3CA TERT	9.25e-04	14	46	2	M16884
Pathway	KEGG_MEDICUS_VARIANT_DUPLICATION_OR_MUTATION_ACTIVATED_FLT3_TO_RAS_PI3K_SIGNALING_PATHWAY	PIK3CA SOS2	9.25e-04	14	46	2	M47390
Pathway	WP_CANCER_IMMUNOTHERAPY_BY_CTLA4_BLOCKADE	PPP2CA PIK3CA	9.25e-04	14	46	2	M39840
Pathway	BIOCARTA_ACH_PATHWAY	PIK3CA TERT	9.25e-04	14	46	2	MM1485
Pathway	KEGG_MEDICUS_REFERENCE_EGF_EGFR_RAS_PI3K_SIGNALING_PATHWAY	PIK3CA SOS2	1.06e-03	15	46	2	M47389
Pathway	REACTOME_SIGNALING_BY_CTNNB1_PHOSPHO_SITE_MUTANTS	PPP2CA PPP2CB	1.06e-03	15	46	2	M27407
Pathway	KEGG_MEDICUS_REFERENCE_FLT3LG_FLT3_RAS_PI3K_SIGNALING_PATHWAY	PIK3CA SOS2	1.06e-03	15	46	2	M47475
Pathway	REACTOME_SIGNALING_BY_FGFR2	PPP2CA PPP2CB PIK3CA	1.07e-03	62	46	3	MM15256
Pathway	REACTOME_SIGNALING_BY_NTRK1_TRKA	PPP2CA PPP2CB PIK3CA	1.13e-03	63	46	3	MM14714
Pathway	KEGG_MEDICUS_REFERENCE_COHESIN_DISSOCIATION_IN_PROPHASE	PPP2CA PPP2CB	1.21e-03	16	46	2	M47870
Pathway	REACTOME_DARPP_32_EVENTS	PPP2CA PPP2CB	1.21e-03	16	46	2	MM14699
Pathway	REACTOME_SPRY_REGULATION_OF_FGF_SIGNALING	PPP2CA PPP2CB	1.21e-03	16	46	2	MM14541
Pathway	REACTOME_SPRY_REGULATION_OF_FGF_SIGNALING	PPP2CA PPP2CB	1.21e-03	16	46	2	M514
Pathway	REACTOME_COSTIMULATION_BY_THE_CD28_FAMILY	PPP2CA PPP2CB PIK3CA	1.29e-03	66	46	3	MM14990
Pathway	REACTOME_PLATELET_SENSITIZATION_BY_LDL	PPP2CA PPP2CB	1.37e-03	17	46	2	MM15096
Pathway	WP_IRON_METABOLISM_DISORDERS	CYBRD1 CP	1.37e-03	17	46	2	M48053
Pathway	BIOCARTA_TEL_PATHWAY	PPP2CA TERT	1.37e-03	17	46	2	MM1508
Pathway	BIOCARTA_TEL_PATHWAY	PPP2CA TERT	1.37e-03	17	46	2	M10401
Pathway	REACTOME_BETA_CATENIN_PHOSPHORYLATION_CASCADE	PPP2CA PPP2CB	1.37e-03	17	46	2	M27083
Pathway	REACTOME_PLATELET_SENSITIZATION_BY_LDL	PPP2CA PPP2CB	1.37e-03	17	46	2	M919
Pathway	REACTOME_BETA_CATENIN_PHOSPHORYLATION_CASCADE	PPP2CA PPP2CB	1.54e-03	18	46	2	MM14759
Pathway	KEGG_OLFACTORY_TRANSDUCTION	OR2T8 OR2T33 OR1B1 OR51B6 OR52N5 OR2T12	1.56e-03	389	46	6	M14091
Pathway	BIOCARTA_IGF1MTOR_PATHWAY	PPP2CA PIK3CA	1.72e-03	19	46	2	M16991
Pathway	KEGG_MEDICUS_REFERENCE_PP2A_AKT_SIGNALING_PATHWAY	PPP2CA PPP2CB	1.72e-03	19	46	2	M47525
Pathway	REACTOME_ERK_MAPK_TARGETS	PPP2CA PPP2CB	1.72e-03	19	46	2	MM14780
Pathway	REACTOME_SIGNALING_BY_FGFR2	PPP2CA PPP2CB PIK3CA	1.72e-03	73	46	3	M27531
Pathway	REACTOME_COSTIMULATION_BY_THE_CD28_FAMILY	PPP2CA PPP2CB PIK3CA	1.79e-03	74	46	3	M17386
Pathway	REACTOME_SIGNALING_BY_NTRKS	PPP2CA PPP2CB PIK3CA	1.86e-03	75	46	3	MM14652
Pathway	KEGG_MEDICUS_REFERENCE_CONDENSIN_LOADING	PPP2CA PPP2CB	1.91e-03	20	46	2	M47876
Pathway	BIOCARTA_MTOR_PATHWAY	PPP2CA PIK3CA	1.91e-03	20	46	2	MM1437
Pathway	BIOCARTA_IGF1MTOR_PATHWAY	PPP2CA PIK3CA	1.91e-03	20	46	2	MM1496
Pathway	BIOCARTA_GSK3_PATHWAY	PPP2CA PIK3CA	1.91e-03	20	46	2	M11106
Pathway	REACTOME_SIGNALING_BY_FGFR	PPP2CA PPP2CB PIK3CA	2.01e-03	77	46	3	MM14722
Pathway	REACTOME_CTLA4_INHIBITORY_SIGNALING	PPP2CA PPP2CB	2.10e-03	21	46	2	M5876
Pathway	REACTOME_CTLA4_INHIBITORY_SIGNALING	PPP2CA PPP2CB	2.10e-03	21	46	2	MM14996
Pathway	REACTOME_SIGNALING_BY_INTERLEUKINS	PPP2CA PPP2CB PIK3CA IL9R SOS2	2.13e-03	281	46	5	MM15130
Pathway	REACTOME_OLFACTORY_SIGNALING_PATHWAY	OR2T8 OR2T33 OR1B1 OR51B6 OR52N5 OR2T12	2.22e-03	417	46	6	M4072
Pathway	REACTOME_ERK_MAPK_TARGETS	PPP2CA PPP2CB	2.31e-03	22	46	2	M13408
Pathway	BIOCARTA_GSK3_PATHWAY	PPP2CA PIK3CA	2.31e-03	22	46	2	MM1421
Pathway	REACTOME_E2F_MEDIATED_REGULATION_OF_DNA_REPLICATION	PPP2CA PPP2CB	2.31e-03	22	46	2	M6768
Pathway	BIOCARTA_MTOR_PATHWAY	PPP2CA PIK3CA	2.31e-03	22	46	2	M16563
Pathway	BIOCARTA_AKT_PATHWAY	PPP2CA PIK3CA	2.31e-03	22	46	2	M15258
Pathway	KEGG_MEDICUS_REFERENCE_CD80_CD86_CTLA4_PP2A_SIGNALING_PATHWAY	PPP2CA PPP2CB	2.31e-03	22	46	2	M47919
Pathway	WP_TRIACYLGLYCERIDE_SYNTHESIS	MOGAT2 AGPS	2.52e-03	23	46	2	MM15890
Pathway	REACTOME_GLUCOSE_METABOLISM	PPP2CA PPP2CB G6PC3	2.66e-03	85	46	3	M1870
Pathway	BIOCARTA_CTCF_PATHWAY	PPP2CA PIK3CA	2.75e-03	24	46	2	M11420
Pathway	BIOCARTA_CTCF_PATHWAY	PPP2CA PIK3CA	2.75e-03	24	46	2	MM1373
Pathway	KEGG_DORSO_VENTRAL_AXIS_FORMATION	NOTCH4 SOS2	2.75e-03	24	46	2	M11190
Pathway	WP_TRIACYLGLYCERIDE_SYNTHESIS	MOGAT2 AGPS	2.75e-03	24	46	2	M39692
Pathway	REACTOME_DARPP_32_EVENTS	PPP2CA PPP2CB	2.75e-03	24	46	2	M751
Pathway	REACTOME_CYCLIN_A_B1_B2_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION	PPP2CA PPP2CB	2.98e-03	25	46	2	M808
Pathway	REACTOME_CYCLIN_A_B1_B2_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION	PPP2CA PPP2CB	2.98e-03	25	46	2	MM15379
Pathway	REACTOME_SIGNALING_BY_FGFR	PPP2CA PPP2CB PIK3CA	3.04e-03	89	46	3	M1090
Pathway	BIOCARTA_AKT_PATHWAY	PPP2CA PIK3CA	3.22e-03	26	46	2	MM1345
Pathway	SIG_IL4RECEPTOR_IN_B_LYPHOCYTES	PIK3CA SOS2	3.47e-03	27	46	2	M1718
Pathway	REACTOME_NUCLEAR_EVENTS_KINASE_AND_TRANSCRIPTION_FACTOR_ACTIVATION	PPP2CA PPP2CB	3.47e-03	27	46	2	MM14779
Pubmed	Expression of the short chain fatty acid receptor GPR41/FFAR3 in autonomic and somatic sensory ganglia.	FFAR3 GPR42	2.55e-06	2	56	2	25637492
Pubmed	Selective tracking of FFAR3-expressing neurons supports receptor coupling to N-type calcium channels in mouse sympathetic neurons.	FFAR3 GPR42	2.55e-06	2	56	2	30478340
Pubmed	3-(4-Hydroxy-3-methoxyphenyl) propionic acid contributes to improved hepatic lipid metabolism via GPR41.	FFAR3 GPR42	2.55e-06	2	56	2	38040866
Pubmed	Activation of SV40 DNA replication in vitro by cellular protein phosphatase 2A.	PPP2CA PPP2CB	2.55e-06	2	56	2	2555176
Pubmed	Genetic Inactivation of Free Fatty Acid Receptor 3 Impedes Behavioral Deficits and Pathological Hallmarks in the APPswe Alzheimer's Disease Mouse Model.	FFAR3 GPR42	2.55e-06	2	56	2	35408893
Pubmed	FFAR3 modulates insulin secretion and global gene expression in mouse islets.	FFAR3 GPR42	2.55e-06	2	56	2	26091414
Pubmed	GPR41 modulates insulin secretion and gene expression in pancreatic β-cells and modifies metabolic homeostasis in fed and fasting states.	FFAR3 GPR42	2.55e-06	2	56	2	27550964
Pubmed	Intestinal FFA3 mediates obesogenic effects in mice on a Western diet.	FFAR3 GPR42	2.55e-06	2	56	2	35858247
Pubmed	Butyrate and propionate protect against diet-induced obesity and regulate gut hormones via free fatty acid receptor 3-independent mechanisms.	FFAR3 GPR42	2.55e-06	2	56	2	22506074
Pubmed	Free fatty acid receptor 3 differentially contributes to β-cell compensation under high-fat diet and streptozotocin stress.	FFAR3 GPR42	2.55e-06	2	56	2	32073900
Pubmed	The role of protein phosphatase 2A catalytic subunit Calpha in embryogenesis: evidence from sequence analysis and localization studies.	PPP2CA PPP2CB	2.55e-06	2	56	2	10543450
Pubmed	Regulation of spindle formation by active mitogen-activated protein kinase and protein phosphatase 2A during mouse oocyte meiosis.	PPP2CA PPP2CB	2.55e-06	2	56	2	11751260
Pubmed	The effects of propionate and valerate on insulin responsiveness for glucose uptake in 3T3-L1 adipocytes and C2C12 myotubes via G protein-coupled receptor 41.	FFAR3 GPR42	2.55e-06	2	56	2	24748202
Pubmed	The Cognitive Improvement and Alleviation of Brain Hypermetabolism Caused by FFAR3 Ablation in Tg2576 Mice Is Persistent under Diet-Induced Obesity.	FFAR3 GPR42	2.55e-06	2	56	2	36362376
Pubmed	Protein phosphatase 2A (PP2A) has a potential role in CAPE-induced apoptosis of CCRF-CEM cells via effecting human telomerase reverse transcriptase activity.	PPP2CA TERT	2.55e-06	2	56	2	17852432
Pubmed	Protein phosphatase 2A in the healthy and failing heart: New insights and therapeutic opportunities.	PPP2CA PPP2CB	2.55e-06	2	56	2	34902541
Pubmed	Roles of GPR41 and GPR43 in leptin secretory responses of murine adipocytes to short chain fatty acids.	FFAR3 GPR42	2.55e-06	2	56	2	20399779
Pubmed	Human liver phosphatase 2A: cDNA and amino acid sequence of two catalytic subunit isotypes.	PPP2CA PPP2CB	2.55e-06	2	56	2	2837763
Pubmed	Sequence polymorphisms provide a common consensus sequence for GPR41 and GPR42.	FFAR3 GPR42	2.55e-06	2	56	2	19630535
Pubmed	Structure and transcriptional regulation of protein phosphatase 2A catalytic subunit genes.	PPP2CA PPP2CB	2.55e-06	2	56	2	1846293
Pubmed	Mutational profiling of poorly differentiated and anaplastic thyroid carcinoma by the use of targeted next-generation sequencing.	PIK3CA TERT	2.55e-06	2	56	2	31230400
Pubmed	Male mice that lack the G-protein-coupled receptor GPR41 have low energy expenditure and increased body fat content.	FFAR3 GPR42	2.55e-06	2	56	2	23110765
Pubmed	PP2A regulates kinetochore-microtubule attachment during meiosis I in oocyte.	PPP2CA PPP2CB	2.55e-06	2	56	2	27096707
Pubmed	The Intestinal Microbiota Contributes to the Ability of Helminths to Modulate Allergic Inflammation.	FFAR3 GPR42	2.55e-06	2	56	2	26522986
Pubmed	Short-chain fatty acids stimulate leptin production in adipocytes through the G protein-coupled receptor GPR41.	FFAR3 GPR42	2.55e-06	2	56	2	14722361
Pubmed	High frequency of PIK3CA and TERT promoter mutations in fibromatosis-like spindle cell carcinomas.	PIK3CA TERT	2.55e-06	2	56	2	33952589
Pubmed	Microbial short chain fatty acid metabolites lower blood pressure via endothelial G protein-coupled receptor 41.	FFAR3 GPR42	2.55e-06	2	56	2	27664183
Pubmed	Serine/threonine-protein phosphatase 2A physically interacts with human telomerase reverse transcriptase hTERT and regulates its subcellular distribution.	PPP2CA TERT	2.55e-06	2	56	2	22961627
Pubmed	Regional expression of protein phosphatase type 1 and 2A catalytic subunit isoforms in the human heart.	PPP2CA PPP2CB	2.55e-06	2	56	2	11113010
Pubmed	Human GPR42 is a transcribed multisite variant that exhibits copy number polymorphism and is functional when heterologously expressed.	FFAR3 GPR42	2.55e-06	2	56	2	26260360
Pubmed	G protein coupled receptor 41 regulates fibroblast activation in pulmonary fibrosis via Gαi/o and downstream Smad2/3 and ERK1/2 phosphorylation.	FFAR3 GPR42	2.55e-06	2	56	2	37019194
Pubmed	Mutations in the telomerase reverse transcriptase promoter and PIK3CA gene are common events in penile squamous cell carcinoma of Italian and Ugandan patients.	PIK3CA TERT	2.55e-06	2	56	2	35253909
Pubmed	Molecular mechanisms involved in HIV-1-Tat mediated inhibition of telomerase activity in human CD4(+) T lymphocytes.	PPP2CA PPP2CB TERT	3.17e-06	18	56	3	23287597
Pubmed	Short-chain fatty acid receptor GPR41-mediated activation of sympathetic neurons involves synapsin 2b phosphorylation.	FFAR3 GPR42	7.63e-06	3	56	2	22673524
Pubmed	The Orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids.	FFAR3 GPR42	7.63e-06	3	56	2	12496283
Pubmed	Short-chain fatty acids activate GPR41 and GPR43 on intestinal epithelial cells to promote inflammatory responses in mice.	FFAR3 GPR42	7.63e-06	3	56	2	23665276
Pubmed	Microbial short-chain fatty acids modulate CD8+ T cell responses and improve adoptive immunotherapy for cancer.	FFAR3 GPR42	7.63e-06	3	56	2	34210970
Pubmed	The catalytic subunit of protein phosphatase 2A is carboxyl-methylated in vivo.	PPP2CA PPP2CB	7.63e-06	3	56	2	8206937
Pubmed	Histone deacetylase inhibitor AR42 regulates telomerase activity in human glioma cells via an Akt-dependent mechanism.	PIK3CA TERT	7.63e-06	3	56	2	23624506
Pubmed	Dietary short-chain fatty acid intake improves the hepatic metabolic condition via FFAR3.	FFAR3 GPR42	7.63e-06	3	56	2	31719611
Pubmed	Acetate and propionate short chain fatty acids stimulate adipogenesis via GPCR43.	FFAR3 GPR42	7.63e-06	3	56	2	16123168
Pubmed	GPR41 gene expression is mediated by internal ribosome entry site (IRES)-dependent translation of bicistronic mRNA encoding GPR40 and GPR41 proteins.	FFAR3 GPR42	7.63e-06	3	56	2	22493486
Pubmed	Tyrosine phosphorylation of protein phosphatase 2A in response to growth stimulation and v-src transformation of fibroblasts.	PPP2CA PPP2CB	7.63e-06	3	56	2	7510677
Pubmed	An extended genome-wide association study identifies novel susceptibility loci for nasopharyngeal carcinoma.	CIITA TERT	7.63e-06	3	56	2	27436580
Pubmed	[THE SOMATIC MUTATIONS AND ABERRANT METHYLATION AS POTENTIAL GENETIC MARKERS OF URINARY BLADDER CANCER].	PIK3CA TERT	7.63e-06	3	56	2	27455559
Pubmed	Extracellular ionic locks determine variation in constitutive activity and ligand potency between species orthologs of the free fatty acid receptors FFA2 and FFA3.	FFAR3 GPR42	7.63e-06	3	56	2	23066016
Pubmed	Loss of FFA2 and FFA3 increases insulin secretion and improves glucose tolerance in type 2 diabetes.	FFAR3 GPR42	7.63e-06	3	56	2	25581519
Pubmed	Short-chain fatty acids stimulate glucagon-like peptide-1 secretion via the G-protein-coupled receptor FFAR2.	FFAR3 GPR42	7.63e-06	3	56	2	22190648
Pubmed	Microbiota-Derived Short-Chain Fatty Acids Promote the Memory Potential of Antigen-Activated CD8+ T Cells.	FFAR3 GPR42	7.63e-06	3	56	2	31272808
Pubmed	GPR41/FFAR3 and GPR43/FFAR2 as cosensors for short-chain fatty acids in enteroendocrine cells vs FFAR3 in enteric neurons and FFAR2 in enteric leukocytes.	FFAR3 GPR42	7.63e-06	3	56	2	23885020
Pubmed	Dietary Fiber Confers Protection against Flu by Shaping Ly6c- Patrolling Monocyte Hematopoiesis and CD8+ T Cell Metabolism.	FFAR3 GPR42	7.63e-06	3	56	2	29768180
Pubmed	Effects of the gut microbiota on host adiposity are modulated by the short-chain fatty-acid binding G protein-coupled receptor, Gpr41.	FFAR3 GPR42	7.63e-06	3	56	2	18931303
Pubmed	GPR41 and GPR43 regulate CD8+ T cell priming during herpes simplex virus type 1 infection.	FFAR3 GPR42	7.63e-06	3	56	2	38524121
Pubmed	Mutation of Tyr307 and Leu309 in the protein phosphatase 2A catalytic subunit favors association with the alpha 4 subunit which promotes dephosphorylation of elongation factor-2.	PPP2CA PPP2CB	7.63e-06	3	56	2	10441131
Pubmed	Abnormalities in microbiota/butyrate/FFAR3 signaling in aging gut impair brain function.	FFAR3 GPR42	7.63e-06	3	56	2	38329121
Pubmed	Protein phosphatase 2A dephosphorylates CaBP4 and regulates CaBP4 function.	PPP2CA PPP2CB	7.63e-06	3	56	2	23341017
Pubmed	Localization of the genes encoding the catalytic subunits of protein phosphatase 2A to human chromosome bands 5q23-->q31 and 8p12-->p11.2, respectively.	PPP2CA PPP2CB	7.63e-06	3	56	2	8383590
Pubmed	Overlapping binding sites in protein phosphatase 2A for association with regulatory A and alpha-4 (mTap42) subunits.	PPP2CA PPP2CB	7.63e-06	3	56	2	15252037
Pubmed	Phosphorylation and microtubule association of the Opitz syndrome protein mid-1 is regulated by protein phosphatase 2A via binding to the regulatory subunit alpha 4.	PPP2CA PPP2CB	1.52e-05	4	56	2	11371618
Pubmed	Olfactory receptor responding to gut microbiota-derived signals plays a role in renin secretion and blood pressure regulation.	FFAR3 GPR42	1.52e-05	4	56	2	23401498
Pubmed	The E3 ubiquitin ligase- and protein phosphatase 2A (PP2A)-binding domains of the Alpha4 protein are both required for Alpha4 to inhibit PP2A degradation.	PPP2CA PPP2CB	1.52e-05	4	56	2	21454489
Pubmed	A cluster of four novel human G protein-coupled receptor genes occurring in close proximity to CD22 gene on chromosome 19q13.1.	FFAR3 GPR42	1.52e-05	4	56	2	9344866
Pubmed	The phosphorylation state of an autoregulatory domain controls PACS-1-directed protein traffic.	PPP2CA PPP2CB	1.52e-05	4	56	2	14633983
Pubmed	Generation of Ppp2Ca and Ppp2Cb conditional null alleles in mouse.	PPP2CA PPP2CB	1.52e-05	4	56	2	21998041
Pubmed	Delayed embryonic lethality in mice lacking protein phosphatase 2A catalytic subunit Calpha.	PPP2CA PPP2CB	1.52e-05	4	56	2	9770493
Pubmed	Short-chain fatty acids and ketones directly regulate sympathetic nervous system via G protein-coupled receptor 41 (GPR41).	FFAR3 GPR42	1.52e-05	4	56	2	21518883
Pubmed	Phosphatase activity toward abnormally phosphorylated tau: decrease in Alzheimer disease brain.	PPP2CA PPP2CB	1.52e-05	4	56	2	7616230
Pubmed	Identification of a domain of Axin that binds to the serine/threonine protein phosphatase 2A and a self-binding domain.	PPP2CA PPP2CB	1.52e-05	4	56	2	9920888
Pubmed	A family of fatty acid binding receptors.	FFAR3 GPR42	1.52e-05	4	56	2	15684720
Pubmed	Iron homeostasis in porphyria cutanea tarda: mutation analysis of promoter regions of CP, CYBRD1, HAMP and SLC40A1.	CYBRD1 CP	1.52e-05	4	56	2	23012398
Pubmed	Maternal High Fiber Diet during Pregnancy and Lactation Influences Regulatory T Cell Differentiation in Offspring in Mice.	FFAR3 GPR42	1.52e-05	4	56	2	29021375
Pubmed	Microbial metabolites, short-chain fatty acids, restrain tissue bacterial load, chronic inflammation, and associated cancer in the colon of mice.	FFAR3 GPR42	1.52e-05	4	56	2	29644622
Pubmed	Different evolutionary processes shaped the mouse and human olfactory receptor gene families.	OR2T8 OR2T33 OR1B1 OR51B6 OR52N5 OR2T12	1.80e-05	340	56	6	11875048
Pubmed	The olfactory receptor gene superfamily of the mouse.	OR2T8 OR2T33 OR1B1 OR51B6 OR52N5 OR2T12	1.80e-05	340	56	6	11802173
Pubmed	A unified nomenclature for vertebrate olfactory receptors.	OR2T8 OR2T33 OR1B1 OR51B6 OR52N5 OR2T12	1.89e-05	343	56	6	32295537
Pubmed	Odorant receptor expressed sequence tags demonstrate olfactory expression of over 400 genes, extensive alternate splicing and unequal expression levels.	OR2T8 OR2T33 OR1B1 OR51B6 OR52N5 OR2T12	1.98e-05	346	56	6	14611657
Pubmed	Regulation of phosphorylation of neuronal microtubule-associated proteins MAP1b and MAP2 by protein phosphatase-2A and -2B in rat brain.	PPP2CA PPP2CB	2.54e-05	5	56	2	10640627
Pubmed	Fatty acid binding receptors and their physiological role in type 2 diabetes.	FFAR3 GPR42	2.54e-05	5	56	2	19009545
Pubmed	Effect of advanced glycation end products on lectin-like oxidized low density lipoprotein receptor-1 expression in endothelial cells.	PIK3CA OLR1	2.54e-05	5	56	2	22863784
Pubmed	Seven transmembrane G protein-coupled receptor repertoire of gastric ghrelin cells.	FFAR3 GPR42	2.54e-05	5	56	2	24327954
Pubmed	HOX11 interacts with protein phosphatases PP2A and PP1 and disrupts a G2/M cell-cycle checkpoint.	PPP2CA PPP2CB	2.54e-05	5	56	2	9009195
Pubmed	Protein phosphatase 2A interacts with and directly dephosphorylates RelA.	PPP2CA PPP2CB	2.54e-05	5	56	2	11591705
Pubmed	Targeted disruption of the PME-1 gene causes loss of demethylated PP2A and perinatal lethality in mice.	PPP2CA PPP2CB	2.54e-05	5	56	2	18596935
Pubmed	Lactate inhibits lipolysis in fat cells through activation of an orphan G-protein-coupled receptor, GPR81.	FFAR3 GPR42	2.54e-05	5	56	2	19047060
Pubmed	Distinct role of protein phosphatase 2A subunit Calpha in the regulation of E-cadherin and beta-catenin during development.	PPP2CA PPP2CB	3.80e-05	6	56	2	10781942
Pubmed	Endotoxin conditioning induces VCP/p97-mediated and inducible nitric-oxide synthase-dependent Tyr284 nitration in protein phosphatase 2A.	PPP2CA PPP2CB	3.80e-05	6	56	2	20100830
Pubmed	Global loss of leucine carboxyl methyltransferase-1 causes severe defects in fetal liver hematopoiesis.	PPP2CA PPP2CB	3.80e-05	6	56	2	29735529
Pubmed	Protein phosphorylation of human brain glutamic acid decarboxylase (GAD)65 and GAD67 and its physiological implications.	PPP2CA PPP2CB	3.80e-05	6	56	2	15147202
Pubmed	STRIPAK components determine mode of cancer cell migration and metastasis.	PPP2CA PPP2CB	3.80e-05	6	56	2	25531779
Pubmed	Free fatty acid receptors act as nutrient sensors to regulate energy homeostasis.	FFAR3 GPR42	3.80e-05	6	56	2	19460454
Pubmed	Alpha 4 associates with protein phosphatases 2A, 4, and 6.	PPP2CA PPP2CB	3.80e-05	6	56	2	9647778
Pubmed	The ubiquitin E3 ligase NOSIP modulates protein phosphatase 2A activity in craniofacial development.	PPP2CA PPP2CB	5.32e-05	7	56	2	25546391
Pubmed	Serum and glucocorticoid-inducible kinase (SGK) is a target of the PI 3-kinase-stimulated signaling pathway.	PPP2CA PIK3CA	5.32e-05	7	56	2	10357815
Pubmed	X-linked microtubule-associated protein, Mid1, regulates axon development.	PPP2CA PPP2CB	5.32e-05	7	56	2	24194544
Pubmed	GSK-3beta-dependent phosphorylation of adenomatous polyposis coli gene product can be modulated by beta-catenin and protein phosphatase 2A complexed with Axin.	PPP2CA PPP2CB	5.32e-05	7	56	2	10698523
Pubmed	Protein phosphatase 2A and separase form a complex regulated by separase autocleavage.	PPP2CA PPP2CB	5.32e-05	7	56	2	17604273
Pubmed	p42 MAP kinase phosphorylation sites in microtubule-associated protein tau are dephosphorylated by protein phosphatase 2A1. Implications for Alzheimer's disease [corrected].	PPP2CA PPP2CB	7.09e-05	8	56	2	1330687
Pubmed	Vagal neuron expression of the microbiota-derived metabolite receptor, free fatty acid receptor (FFAR3), is necessary for normal feeding behavior.	FFAR3 GPR42	7.09e-05	8	56	2	34626852
Pubmed	Cytosolic Arl2 is complexed with cofactor D and protein phosphatase 2A.	PPP2CA PPP2CB	7.09e-05	8	56	2	12912990
Pubmed	Deubiquitinase OTUD6A promotes breast cancer progression by increasing TopBP1 stability and rendering tumor cells resistant to DNA-damaging therapy.	PPP2CA PPP2CB	7.09e-05	8	56	2	35768646
Interaction	OR2T12 interactions	OR2T33 OR2T12	6.53e-06	2	52	2	int:OR2T12
Interaction	OR2T33 interactions	OR2T33 OR2T12	1.96e-05	3	52	2	int:OR2T33
Cytoband	1q44	OR2T8 OR2T33 OR2T12	3.21e-04	110	55	3	1q44
Cytoband	Ensembl 112 genes in cytogenetic band chr1q44	OR2T8 OR2T33 OR2T12	5.00e-04	128	55	3	chr1q44
Cytoband	11p15.4	DNHD1 OR51B6 OR52N5	1.81e-03	200	55	3	11p15.4
Cytoband	19q13.1	FFAR3 GPR42	2.01e-03	55	55	2	19q13.1
Cytoband	5q31.1	CCNI2 PPP2CA	2.63e-03	63	55	2	5q31.1
Cytoband	Ensembl 112 genes in cytogenetic band chr11p15	DNHD1 OR51B6 UBQLN3 OR52N5	4.69e-03	564	55	4	chr11p15
GeneFamily	Protein phosphatase catalytic subunits\|EF-hand domain containing	PPP2CA PPP2CB	3.13e-04	13	37	2	693
GeneFamily	Protein phosphatase catalytic subunits\|STRIPAK complex	PPP2CA PPP2CB	7.56e-04	20	37	2	1371
GeneFamily	Olfactory receptors, family 2	OR2T8 OR2T33 OR2T12	1.58e-03	113	37	3	149
GeneFamily	C-type lectin domain family	CLEC19A OLR1	4.16e-03	47	37	2	494
ToppCell	Sepsis-Bac-SEP-Lymphocyte-T/NK-CD8+_T_naive\|Bac-SEP / Disease, condition lineage and cell class	NRIP2 GPLD1 NRTN RNF212 CP	4.17e-06	198	54	5	a9a009e5eeb935232034635ad4a3c27d83c081ac
ToppCell	Sigmoid-(5)_Dendritic_cell-(50)_cDC2\|Sigmoid / shred on region, Cell_type, and subtype	CYBRD1 CIITA FAM178B OLR1 RASAL1	4.27e-06	199	54	5	402af84db90d8a49d67cf44c24766aefb00fd716
ToppCell	Sigmoid-Dendritic_cell-cDC2\|Sigmoid / Region, Cell class and subclass	CYBRD1 CIITA FAM178B OLR1 RASAL1	4.27e-06	199	54	5	cd74db6db694b68f81dcf9d9342d125d00357ec1
ToppCell	E18.5-samps-Epithelial-Alveolar_epithelial-AT2_progenitor\|E18.5-samps / Age Group, Lineage, Cell class and subclass	KIF21B COL9A1 CYBRD1 GRIK4	1.61e-05	125	54	4	b5fed0e0295aa8ad323c318b59bf23cde3e758c8
Disease	Iron Overload	CYBRD1 CP	5.64e-05	7	49	2	C0282193
Disease	myocardial infarction (is_implicated_in)	CIITA APOH OLR1	6.03e-04	99	49	3	DOID:5844 (is_implicated_in)
Disease	Pigmented Basal Cell Carcinoma	PIK3CA TERT	9.93e-04	28	49	2	C1368275
Disease	Carcinoma, Basal Cell	PIK3CA TERT	1.07e-03	29	49	2	C4721806
Disease	arteriosclerosis (is_marker_for)	APOH NOTCH4	1.07e-03	29	49	2	DOID:2349 (is_marker_for)
Disease	bowel opening frequency	FFAR3 GPR42	1.14e-03	30	49	2	EFO_0600084
Disease	Liver carcinoma	ARID1B MOGAT2 PIK3CA CP TERT	1.50e-03	507	49	5	C2239176

Protein segments in the cluster

Peptide	Gene	Start	Entry
DFPPRLCLHSMSLWG	nan	271	Q6ZR03
MRKFICPLTGLWPIN	APOH	61	P02749
WAPLSLRAFLMPIHV	CYBRD1	146	Q53TN4
LRRCPHVETLAMWTP	CIITA	1096	P33076
LERLMPGWCAPISDL	CCNI2	316	Q6ZMN8
LPILDGLLHWMVCPS	ARID1B	2116	Q8NFD5
AWHECEMLELLPPFV	DNHD1	3986	Q96M86
MGFHFCIWIIFLLPP	PKD1L1-AS1	1	Q9H7B7
ELWMAPLHPFLLQCV	RASAL1	521	O95294
MHYPCLEKPRIWSLA	IRX6	341	P78412
LEALCRHWPGPMSLA	LARGE2	446	Q8N3Y3
WMCREGLLLSHRLGP	NRTN	21	Q99748
LEMFPRTPGIWLLHC	CP	1026	P00450
LHTMLRVGLVLPLCW	OR1B1	156	Q8NGR6
HPLRYPTLMSWQLCL	OR2T12	126	Q8NG77
PCLVLALVPWAVHMF	G6PC3	321	Q9BUM1
ICLPPAQLYHWVEMR	OPA3	41	Q9H6K4
GLSIMPIVVRLHWFP	OR51B6	151	Q9H340
HPLRYPTLMSWQLCL	OR2T8	126	A6NH00
DWVCALAFIPGRPML	KIF21B	1546	O75037
TLPLHLMALLGCWQP	METTL7B	16	Q6UX53
VWFLPPVCMAHCIRL	FAM120A	136	Q9NZB2
HPLRYPTLMSWQLCL	OR2T33	126	Q8NG76
LQEVPHEGPMCDLLW	PPP2CB	186	P62714
LQEVPHEGPMCDLLW	PPP2CA	186	P67775
LWEDGSPLMPHLFRV	OLR1	216	P78380
ANGMHWPLPFILCPL	GPR42	76	O15529
WGIHLMPPRILVECL	PIK3CA	11	P42336
IFPGIRPHLMMLTLW	MOGAT2	131	Q3SYC2
SWLDQHCSLPILRPM	MLXIP	866	Q9HAP2
MACAVFQIPPWHLDR	CCNYL3	1	P0C7X3
NCHLAPSWMPALERL	DNAH1	3731	Q9P2D7
HALRIPMSALPYCTW	ATG9A	166	Q7Z3C6
ANGMHWPLPFILCPL	FFAR3	76	O14843
LRSCMGLEWFPELYP	C17orf80	456	Q9BSJ5
WAPFFLHLTLMLSCP	MC5R	251	P33032
VPFELQWMLIHCDPL	COL9A1	231	P20849
LPAWLVMVACSPHSL	GRIK4	11	Q16099
MWPAPCSVGRLLIFF	SDIM1	1	Q6ZPB5
MPLFNSLCWFPTIHV	OR52N5	1	Q8NH56
MLFIFPLSLPWRPSC	NRIP2	1	Q9BQI9
VLPRLMLVPVYHCWH	SOS2	336	Q07890
LPPKGRVLIHWMTLC	TMEM126B	176	Q8IUX1
LHMPDCPVSLLQWLF	FAM178B	316	Q8IXR5
PMFWPEEERRCLLQG	SETD6	156	Q8TBK2
HCILTWSISPALEPM	IL9R	161	Q01113
CPWDPGLLLRFLAAM	NOTCH4	1401	Q99466
MFERIPDIVLWPTCH	AGPS	201	O00116
RHHLGLCWPIPDTYM	C12orf29	266	Q8N999
LPSLCPLFWMEFKGH	CLEC19A	36	Q6UXS0
FMVEEPGRFLPLWLH	CNNM4	171	Q6P4Q7
MGPHLTASFCFIPWL	RNF212	191	Q495C1
VLLMHLPPEEAFWCL	TBC1D10C	186	Q8IV04
LWPGLLIMLGSLCHR	GPLD1	6	P80108
VRSLKLPPWACGFIM	PREPL	381	Q4J6C6
LLPKLWAFICELGPH	UBE3B	491	Q7Z3V4
PHPALWRMVFGLSVL	PTDSS1	96	P48651
TEAPRLLLWFMPCLA	UBQLN3	536	Q9H347
QMPAHGLFPWCGLLL	TERT	921	O14746
LPCTLAMWELGHCDP	TSR3	56	Q9UJK0