Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	chromatin-protein adaptor activity	YEATS2 RNF169 MDC1 RPA1	2.38e-05	41	82	4	GO:0140463
GeneOntologyMolecularFunction	histone reader activity	YEATS2 RNF169 MDC1	1.62e-04	26	82	3	GO:0140566
GeneOntologyMolecularFunction	RNA strand annealing activity	FXR1 FMR1	1.65e-04	5	82	2	GO:0033592
GeneOntologyBiologicalProcess	regulation of translation at synapse, modulating synaptic transmission	FXR1 FMR1 FXR2 EIF4A3	2.74e-08	9	81	4	GO:0099547
GeneOntologyBiologicalProcess	regulation of translation at presynapse, modulating synaptic transmission	FXR1 FMR1 FXR2	5.83e-08	3	81	3	GO:0099577
GeneOntologyBiologicalProcess	regulation of translation at presynapse	FXR1 FMR1 FXR2	5.83e-08	3	81	3	GO:0140244
GeneOntologyBiologicalProcess	regulation of translation at synapse	FXR1 FMR1 FXR2 EIF4A3	1.54e-07	13	81	4	GO:0140243
GeneOntologyBiologicalProcess	positive regulation of long-term neuronal synaptic plasticity	FXR1 FMR1 FXR2	9.41e-06	11	81	3	GO:0048170
GeneOntologyBiologicalProcess	regulation of translation at postsynapse, modulating synaptic transmission	FMR1 EIF4A3	9.09e-05	4	81	2	GO:0099578
GeneOntologyCellularComponent	dendritic filopodium	FMR1 MAP2	9.07e-05	4	82	2	GO:1902737
Domain	FXMRP1_C_core	FXR1 FMR1 FXR2	7.86e-08	3	81	3	IPR022034
Domain	Agenet-like_dom	FXR1 FMR1 FXR2	7.86e-08	3	81	3	IPR008395
Domain	Agenet	FXR1 FMR1 FXR2	7.86e-08	3	81	3	PF05641
Domain	FXMRP1_C_core	FXR1 FMR1 FXR2	7.86e-08	3	81	3	PF12235
Domain	AGENET_LIKE	FXR1 FMR1 FXR2	7.86e-08	3	81	3	PS51641
Domain	KH_1	FXR1 FMR1 FXR2 MEX3B MEX3C	6.07e-07	38	81	5	PF00013
Domain	-	FXR1 FMR1 FXR2 MEX3B MEX3C	6.94e-07	39	81	5	3.30.1370.10
Domain	KH	FXR1 FMR1 FXR2 MEX3B MEX3C	7.91e-07	40	81	5	SM00322
Domain	KH_dom	FXR1 FMR1 FXR2 MEX3B MEX3C	7.91e-07	40	81	5	IPR004087
Domain	KH_TYPE_1	FXR1 FMR1 FXR2 MEX3B MEX3C	1.02e-06	42	81	5	PS50084
Domain	KH_dom_type_1	FXR1 FMR1 FXR2 MEX3B MEX3C	1.29e-06	44	81	5	IPR004088
Domain	FXR_C1	FXR1 FXR2	1.86e-05	2	81	2	PF16096
Domain	FXR_C1	FXR1 FXR2	1.86e-05	2	81	2	IPR032172
Domain	TAU_MAP_1	MAP2 MAP4	5.56e-05	3	81	2	PS00229
Domain	TAU_MAP_2	MAP2 MAP4	5.56e-05	3	81	2	PS51491
Domain	Tubulin-binding	MAP2 MAP4	5.56e-05	3	81	2	PF00418
Domain	MAP_tubulin-bd_rpt	MAP2 MAP4	5.56e-05	3	81	2	IPR001084
Domain	MAP2/MAP4/Tau	MAP2 MAP4	5.56e-05	3	81	2	IPR027324
Domain	Desmoglein	DSG2 DSG4	1.11e-04	4	81	2	IPR009123
Domain	Desmosomal_cadherin	DSG2 DSG4	3.85e-04	7	81	2	IPR009122
Domain	NA-bd_OB-fold	FXR1 CT55 PDCD11 RPA1	4.65e-04	83	81	4	IPR012340
Domain	ARM-like	DNAJC13 SETX AP1G1 XPO6 PSMD2 AP4B1	1.13e-03	270	81	6	IPR011989
Domain	VWA	PARP4 COL12A1 COL6A6	1.85e-03	56	81	3	PF00092
Domain	Clathrin/coatomer_adapt-like_N	AP1G1 AP4B1	1.88e-03	15	81	2	IPR002553
Domain	Adaptin_N	AP1G1 AP4B1	1.88e-03	15	81	2	PF01602
Domain	TSP_1	THSD7A ADAMTSL3 SSPOP	2.59e-03	63	81	3	PF00090
Domain	-	DNAJC13 AP1G1 XPO6 PSMD2 AP4B1	2.79e-03	222	81	5	1.25.10.10
Domain	TSP1	THSD7A ADAMTSL3 SSPOP	2.83e-03	65	81	3	SM00209
Domain	TSP1_rpt	THSD7A ADAMTSL3 SSPOP	2.83e-03	65	81	3	IPR000884
Domain	TSP1	THSD7A ADAMTSL3 SSPOP	2.83e-03	65	81	3	PS50092
Domain	BRCT	PARP4 MDC1	3.03e-03	19	81	2	PF00533
Domain	ARM-type_fold	DNAJC13 AP1G1 XPO6 PSMD2 AP4B1 RALGAPA2	3.54e-03	339	81	6	IPR016024
Domain	BRCT	PARP4 MDC1	4.06e-03	22	81	2	SM00292
Domain	-	PARP4 COL12A1 COL6A6	4.08e-03	74	81	3	3.40.50.410
Domain	TSPN	COL12A1 COL19A1	4.43e-03	23	81	2	SM00210
Domain	-	PARP4 MDC1	4.43e-03	23	81	2	3.40.50.10190
Domain	Cadherin_cytoplasmic-dom	DSG2 DSG4	5.22e-03	25	81	2	IPR000233
Domain	Cadherin_C	DSG2 DSG4	5.22e-03	25	81	2	PF01049
Domain	VWFA	PARP4 COL12A1 COL6A6	5.44e-03	82	81	3	PS50234
Domain	BRCT	PARP4 MDC1	5.64e-03	26	81	2	PS50172
Domain	VWA	PARP4 COL12A1 COL6A6	5.82e-03	84	81	3	SM00327
Domain	Collagen	COL12A1 COL19A1 COL6A6	6.01e-03	85	81	3	IPR008160
Domain	Collagen	COL12A1 COL19A1 COL6A6	6.01e-03	85	81	3	PF01391
Domain	HECT	HECTD2 HERC3	6.08e-03	27	81	2	PF00632
Domain	HECTc	HECTD2 HERC3	6.08e-03	27	81	2	SM00119
Domain	HECT_dom	HECTD2 HERC3	6.08e-03	27	81	2	IPR000569
Domain	IPT	PLXNC1 NFKB1	6.08e-03	27	81	2	SM00429
Domain	HECT	HECTD2 HERC3	6.08e-03	27	81	2	PS50237
Domain	BRCT_dom	PARP4 MDC1	6.53e-03	28	81	2	IPR001357
Domain	Catenin_binding_dom	DSG2 DSG4	6.99e-03	29	81	2	IPR027397
Domain	-	DSG2 DSG4	6.99e-03	29	81	2	4.10.900.10
Domain	TIG	PLXNC1 NFKB1	7.96e-03	31	81	2	PF01833
Domain	FHA	APTX MDC1	7.96e-03	31	81	2	PF00498
Domain	IPT	PLXNC1 NFKB1	8.47e-03	32	81	2	IPR002909
Pathway	PID_NFKAPPAB_CANONICAL_PATHWAY	CYLD NFKB1 SSPOP CHUK	3.21e-06	23	64	4	M37
Pathway	KEGG_MEDICUS_PATHOGEN_KSHV_VFLIP_TO_NFKB_SIGNALING_PATHWAY	NFKB1 CHUK	3.01e-04	6	64	2	M47462
Pathway	REACTOME_IKBA_VARIANT_LEADS_TO_EDA_ID	NFKB1 CHUK	4.20e-04	7	64	2	M27463
Pathway	KEGG_MEDICUS_PATHOGEN_KSHV_VFLIP_TO_TNF_NFKB_SIGNALING_PATHWAY	NFKB1 CHUK	4.20e-04	7	64	2	M47464
Pathway	WP_RESISTIN_AS_A_REGULATOR_OF_INFLAMMATION	NFKB1 PLCD4 CHUK	4.42e-04	33	64	3	M39745
Pathway	REACTOME_DDX58_IFIH1_MEDIATED_INDUCTION_OF_INTERFERON_ALPHA_BETA	CYLD NFKB1 CHUK	4.42e-04	33	64	3	MM14666
Pathway	WP_PHOTODYNAMIC_THERAPYINDUCED_NFKB_SURVIVAL_SIGNALING	EGLN2 NFKB1 CHUK	5.27e-04	35	64	3	M39529
Pathway	WP_CANONICAL_NFKB_PATHWAY	NFKB1 CHUK	5.58e-04	8	64	2	M39783
Pathway	KEGG_MEDICUS_PATHOGEN_KSHV_K15_TO_TNF_NFKB_SIGNALING_PATHWAY	NFKB1 CHUK	5.58e-04	8	64	2	M47463
Pathway	WP_ALTERED_GLYCOSYLATION_OF_MUC1_IN_TUMOR_MICROENVIRONMENT	NFKB1 CHUK	7.16e-04	9	64	2	M39757
Pathway	WP_SUPPRESSION_OF_HMGB1MEDIATED_INFLAMMATION_BY_THBD	NFKB1 CHUK	7.16e-04	9	64	2	M39509
Pathway	KEGG_MEDICUS_REFERENCE_NOD_NFKB_SIGNALING_PATHWAY	NFKB1 CHUK	7.16e-04	9	64	2	M47652
Pathway	BIOCARTA_RNA_PATHWAY	NFKB1 CHUK	7.16e-04	9	64	2	MM1382
Pathway	KEGG_MEDICUS_PATHOGEN_SALMONELLA_SOPE_E2_TO_NOD_NFKB_SIGNALING_PATHWAY	NFKB1 CHUK	7.16e-04	9	64	2	M47734
Pathway	REACTOME_O_GLYCOSYLATION_OF_TSR_DOMAIN_CONTAINING_PROTEINS	THSD7A ADAMTSL3 SSPOP	7.26e-04	39	64	3	M27417
Pathway	REACTOME_O_GLYCOSYLATION_OF_TSR_DOMAIN_CONTAINING_PROTEINS	THSD7A ADAMTSL3 SSPOP	7.26e-04	39	64	3	MM15165
Pathway	REACTOME_COLLAGEN_CHAIN_TRIMERIZATION	COL12A1 COL19A1 COL6A6	8.41e-04	41	64	3	MM15538
Pathway	KEGG_MEDICUS_REFERENCE_LIGHT_HVEM_NFKB_SIGNALING_PATHWAY	NFKB1 CHUK	8.92e-04	10	64	2	M47599
Pathway	KEGG_MEDICUS_REFERENCE_TLR3_NFKB_SIGNALING_PATHWAY	NFKB1 CHUK	8.92e-04	10	64	2	M47601
Pathway	BIOCARTA_RNA_PATHWAY	NFKB1 CHUK	8.92e-04	10	64	2	M10570
Pubmed	Fragile X related protein 1 clusters with ribosomes and messenger RNAs at a subset of dendritic spines in the mouse hippocampus.	FXR1 FMR1 MAP2 FXR2	9.82e-09	11	83	4	22022532
Pubmed	Spatial control of nucleoporin condensation by fragile X-related proteins.	FXR1 FMR1 FXR2	1.31e-08	3	83	3	32706158
Pubmed	The fragile X mental retardation syndrome protein interacts with novel homologs FXR1 and FXR2.	FXR1 FMR1 FXR2	1.31e-08	3	83	3	7489725
Pubmed	Specific sequences in the fragile X syndrome protein FMR1 and the FXR proteins mediate their binding to 60S ribosomal subunits and the interactions among them.	FXR1 FMR1 FXR2	1.31e-08	3	83	3	8668200
Pubmed	Sub-synaptic, multiplexed analysis of proteins reveals Fragile X related protein 2 is mislocalized in Fmr1 KO synapses.	FXR1 FMR1 FXR2	1.31e-08	3	83	3	27770568
Pubmed	Discrimination of common and unique RNA-binding activities among Fragile X mental retardation protein paralogs.	FXR1 FMR1 FXR2	1.31e-08	3	83	3	19487368
Pubmed	Fragile X mental retardation protein has a unique, evolutionarily conserved neuronal function not shared with FXR1P or FXR2P.	FXR1 FMR1 FXR2	1.31e-08	3	83	3	20442204
Pubmed	LLPS of FXR proteins drives replication organelle clustering for β-coronaviral proliferation.	FXR1 FMR1 FXR2	1.31e-08	3	83	3	38587486
Pubmed	Differential expression of FMR1, FXR1 and FXR2 proteins in human brain and testis.	FXR1 FMR1 FXR2	1.31e-08	3	83	3	9259278
Pubmed	Fragile X-related proteins regulate mammalian circadian behavioral rhythms.	FXR1 FMR1 FXR2	1.31e-08	3	83	3	18589395
Pubmed	Trapping of messenger RNA by Fragile X Mental Retardation protein into cytoplasmic granules induces translation repression.	FXR1 FMR1 FXR2	1.31e-08	3	83	3	12417522
Pubmed	The fragile X-related proteins FXR1P and FXR2P contain a functional nucleolar-targeting signal equivalent to the HIV-1 regulatory proteins.	FXR1 FMR1 FXR2	1.31e-08	3	83	3	10888599
Pubmed	Evidence that fragile X mental retardation protein is a negative regulator of translation.	FXR1 FMR1 FXR2	1.31e-08	3	83	3	11157796
Pubmed	Fragile X-related protein family: a double-edged sword in neurodevelopmental disorders and cancer.	FXR1 FMR1 FXR2	1.31e-08	3	83	3	32878499
Pubmed	Accumulated common variants in the broader fragile X gene family modulate autistic phenotypes.	FXR1 FMR1 FXR2	1.31e-08	3	83	3	26612855
Pubmed	A novel RNA-binding nuclear protein that interacts with the fragile X mental retardation (FMR1) protein.	FXR1 FMR1 FXR2	5.23e-08	4	83	3	10556305
Pubmed	Isolation of an FMRP-associated messenger ribonucleoprotein particle and identification of nucleolin and the fragile X-related proteins as components of the complex.	FXR1 FMR1 FXR2	5.23e-08	4	83	3	10567518
Pubmed	The nuclear microspherule protein 58 is a novel RNA-binding protein that interacts with fragile X mental retardation protein in polyribosomal mRNPs from neurons.	FXR1 FMR1 FXR2	5.23e-08	4	83	3	16571602
Pubmed	Tdrd3 is a novel stress granule-associated protein interacting with the Fragile-X syndrome protein FMRP.	FXR1 FMR1 FXR2	5.23e-08	4	83	3	18664458
Pubmed	Identification of proximal SUMO-dependent interactors using SUMO-ID.	YEATS2 RNF169 FXR1 SETX MAP4 LIN54 PSMD2 CPS1 RPA1 EMSY	1.10e-07	444	83	10	34795231
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	TRPM6 FXR1 FMR1 AP1G1 DSG2 MAP4 EIF4A3 MDC1 ABCD3 PDCD11 PSMD2 COPS3 RPA1 GDI2 LAP3 PRDM2	2.25e-07	1425	83	16	30948266
Pubmed	TRIM65 regulates microRNA activity by ubiquitination of TNRC6.	FXR1 FMR1 AP1G1 FXR2 EIF4A3 NOA1 RBM28 CPS1 CNOT2	2.27e-07	364	83	9	24778252
Pubmed	A highly conserved protein family interacting with the fragile X mental retardation protein (FMRP) and displaying selective interactions with FMRP-related proteins FXR1P and FXR2P.	FXR1 FMR1 FXR2	2.61e-07	6	83	3	11438699
Pubmed	PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.	YEATS2 BPTF SETX MAP4 EIF4A3 LIN54 MCTS1 COPS3 RBM28 RPA1 GDI2 EMSY PRRC2B PRDM2	3.31e-07	1103	83	14	34189442
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	BPTF FXR1 FMR1 MAP4 FXR2 MDC1 PDCD11 PSMD2 RBM28 GDI2 PRRC2B	4.46e-07	653	83	11	22586326
Pubmed	DYRK1a mediates BAFF-induced noncanonical NF-κB activation to promote autoimmunity and B-cell leukemogenesis.	CYLD DNAJC13 FXR1 NFKB1 KDSR	7.34e-07	70	83	5	34255829
Pubmed	Network organization of the human autophagy system.	FMR1 MAP4 XIRP2 FXR2 ABCD3 PSMD2 RPA1 GDI2 LAP3	1.04e-06	437	83	9	20562859
Pubmed	Human transcription factor protein interaction networks.	CYLD YEATS2 BPTF LIN54 NFKB1 MDC1 ABCD3 PDCD11 PSMD2 RBM28 RPA1 CNOT2 EMSY PRRC2B PRDM2	1.31e-06	1429	83	15	35140242
Pubmed	E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.	CFAP47 PARP4 SETX FXR2 ABCD3 ZBTB41 RBM28 RPA1 SSPOP DNAH14 PRDM2	1.43e-06	736	83	11	29676528
Pubmed	Crosstalk between the NF-kappaB activating IKK-complex and the CSN signalosome.	NFKB1 COPS3 CHUK	2.13e-06	11	83	3	19656241
Pubmed	FXR1P but not FMRP regulates the levels of mammalian brain-specific microRNA-9 and microRNA-124.	FXR1 FMR1 FXR2	2.13e-06	11	83	3	21957233
Pubmed	Fbxo4-mediated degradation of Fxr1 suppresses tumorigenesis in head and neck squamous cell carcinoma.	FXR1 FMR1 FXR2	2.13e-06	11	83	3	29142209
Pubmed	H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.	YEATS2 BPTF RNF169 SETX FMR1 EIF4A3 LIN54 APTX MDC1 PDCD11 RBM28 RPA1 EMSY PRDM2	2.18e-06	1294	83	14	30804502
Pubmed	TBK1 phosphorylation activates LIR-dependent degradation of the inflammation repressor TNIP1.	FXR1 FMR1 DSG2 MAP4 FXR2 EIF4A3 MDC1 PDCD11 PSMD2 RBM28 CPS1 RPA1	2.60e-06	949	83	12	36574265
Pubmed	Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1.	PARP4 TMEM94 MDC1 PDCD11	2.85e-06	41	83	4	8724849
Pubmed	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.	FXR1 FMR1 MAP4 FXR2 EIF4A3 PDCD11 RBM28 GDI2 MEX3B PRRC2B MEX3C	3.47e-06	807	83	11	22681889
Pubmed	Proteome-wide identification of HSP70/HSC70 chaperone clients in human cells.	DNAJC13 FXR1 AP1G1 DSG2 MAP4 LIN54 NFKB1 PDCD11 PSMD2 COPS3 GDI2 LAP3 EMSY PRRC2B	4.11e-06	1367	83	14	32687490
Pubmed	CK2 phosphorylation-dependent interaction between aprataxin and MDC1 in the DNA damage response.	APTX MDC1	5.63e-06	2	83	2	20008512
Pubmed	Vacuolating cytotoxin in Helicobacter pylori water-soluble proteins upregulates chemokine expression in human eosinophils via Ca2+ influx, mitochondrial reactive oxygen intermediates, and NF-kappaB activation.	NFKB1 CHUK	5.63e-06	2	83	2	17452475
Pubmed	The fragile X syndrome protein FMRP associates with BC1 RNA and regulates the translation of specific mRNAs at synapses.	FXR1 FMR1	5.63e-06	2	83	2	12581522
Pubmed	Thymocyte-specific truncation of the deubiquitinating domain of CYLD impairs positive selection in a NF-kappaB essential modulator-dependent manner.	CYLD NFKB1	5.63e-06	2	83	2	20644164
Pubmed	Kaposi's sarcoma-associated herpesvirus (KSHV) oncoprotein K13 bypasses TRAFs and directly interacts with the IkappaB kinase complex to selectively activate NF-kappaB without JNK activation.	NFKB1 CHUK	5.63e-06	2	83	2	17597077
Pubmed	Enterotoxigenic Escherichia coli prevents host NF-κB activation by targeting IκBα polyubiquitination.	NFKB1 CHUK	5.63e-06	2	83	2	23027537
Pubmed	NF-kappaB is essential for induction of CYLD, the negative regulator of NF-kappaB: evidence for a novel inducible autoregulatory feedback pathway.	CYLD NFKB1	5.63e-06	2	83	2	15226292
Pubmed	A reporter screen in a human haploid cell line identifies CYLD as a constitutive inhibitor of NF-κB.	CYLD NFKB1	5.63e-06	2	83	2	23861985
Pubmed	Highly conserved 3' UTR and expression pattern of FXR1 points to a divergent gene regulation of FXR1 and FMR1.	FXR1 FMR1	5.63e-06	2	83	2	8634689
Pubmed	Strain-dependent activation of NF-kappaB in the airway epithelium and its role in allergic airway inflammation.	NFKB1 CHUK	5.63e-06	2	83	2	19897746
Pubmed	Prolyl hydroxylase-1 regulates hepatocyte apoptosis in an NF-κB-dependent manner.	EGLN2 NFKB1	5.63e-06	2	83	2	27130823
Pubmed	On the aggregation properties of FMRP--a link with the FXTAS syndrome?	FMR1 FXR2	5.63e-06	2	83	2	21446998
Pubmed	NF-κB links CO2 sensing to innate immunity and inflammation in mammalian cells.	NFKB1 CHUK	5.63e-06	2	83	2	20817876
Pubmed	Dicer-derived microRNAs are utilized by the fragile X mental retardation protein for assembly on target RNAs.	FXR1 FMR1	5.63e-06	2	83	2	17057366
Pubmed	The FXG: a presynaptic fragile X granule expressed in a subset of developing brain circuits.	FMR1 FXR2	5.63e-06	2	83	2	19193898
Pubmed	Structural studies of the tandem Tudor domains of fragile X mental retardation related proteins FXR1 and FXR2.	FXR1 FXR2	5.63e-06	2	83	2	21072162
Pubmed	IKKs and tumor cell plasticity.	NFKB1 CHUK	5.63e-06	2	83	2	29582565
Pubmed	Different targets for the fragile X-related proteins revealed by their distinct nuclear localizations.	FXR1 FXR2	5.63e-06	2	83	2	10196376
Pubmed	Aging is associated with greater nuclear NF kappa B, reduced I kappa B alpha, and increased expression of proinflammatory cytokines in vascular endothelial cells of healthy humans.	NFKB1 CHUK	5.63e-06	2	83	2	18782346
Pubmed	The RNA-binding protein fragile X-related 1 regulates somite formation in Xenopus laevis.	FXR1 FMR1	5.63e-06	2	83	2	16000371
Pubmed	Classical NF-κB activation impairs skeletal muscle oxidative phenotype by reducing IKK-α expression.	NFKB1 CHUK	5.63e-06	2	83	2	24215713
Pubmed	Comparative genomic sequence analysis of the FXR gene family: FMR1, FXR1, and FXR2.	FXR1 FXR2	5.63e-06	2	83	2	11735223
Pubmed	Phospholipase C δ4 regulates cold sensitivity in mice.	PLCD4 TRPM8	5.63e-06	2	83	2	27062607
Pubmed	Modification of the cysteine residues in IkappaBalpha kinase and NF-kappaB (p65) by xanthohumol leads to suppression of NF-kappaB-regulated gene products and potentiation of apoptosis in leukemia cells.	NFKB1 CHUK	5.63e-06	2	83	2	18952893
Pubmed	De-ubiquitylation is the most critical step in the ubiquitin-mediated homeostatic control of the NF-kappaB/IKK basal activity.	NFKB1 CHUK	5.63e-06	2	83	2	19421711
Pubmed	Complete primary structure of two splice variants of collagen XII, and assignment of alpha 1(XII) collagen (COL12A1), alpha 1(IX) collagen (COL9A1), and alpha 1(XIX) collagen (COL19A1) to human chromosome 6q12-q13.	COL12A1 COL19A1	5.63e-06	2	83	2	9143499
Pubmed	Deficient Sleep in Mouse Models of Fragile X Syndrome.	FMR1 FXR2	5.63e-06	2	83	2	28919851
Pubmed	Interphase and monoastral-mitotic phenotypes of overexpressed MAP4 are modulated by free tubulin concentrations.	MAP2 MAP4	5.63e-06	2	83	2	12890753
Pubmed	IκB kinase-driven nuclear factor-κB activation in patients with asthma and chronic obstructive pulmonary disease.	NFKB1 CHUK	5.63e-06	2	83	2	21571356
Pubmed	IKK/NF-κB signaling contributes to glioblastoma stem cell maintenance.	NFKB1 CHUK	5.63e-06	2	83	2	27732951
Pubmed	Altered hippocampal synaptic plasticity in the FMR1 gene family knockout mouse models.	FMR1 FXR2	5.63e-06	2	83	2	19244359
Pubmed	FXR1, an autosomal homolog of the fragile X mental retardation gene.	FXR1 FMR1	5.63e-06	2	83	2	7781595
Pubmed	Inhibition of IKK/NF-κB Signaling Enhances Differentiation of Mesenchymal Stromal Cells from Human Embryonic Stem Cells.	NFKB1 CHUK	5.63e-06	2	83	2	26972683
Pubmed	Vitamin K suppresses the lipopolysaccharide-induced expression of inflammatory cytokines in cultured macrophage-like cells via the inhibition of the activation of nuclear factor κB through the repression of IKKα/β phosphorylation.	NFKB1 CHUK	5.63e-06	2	83	2	20149620
Pubmed	Expression of CYLD and NF-kappaB in human cholesteatoma epithelium.	CYLD NFKB1	5.63e-06	2	83	2	20414373
Pubmed	Oligomerization properties of fragile-X mental-retardation protein (FMRP) and the fragile-X-related proteins FXR1P and FXR2P.	FXR1 FMR1	5.63e-06	2	83	2	10527928
Pubmed	Exaggerated behavioral phenotypes in Fmr1/Fxr2 double knockout mice reveal a functional genetic interaction between Fragile X-related proteins.	FMR1 FXR2	5.63e-06	2	83	2	16675531
Pubmed	The Fragile X proteins Fmrp and Fxr2p cooperate to regulate glucose metabolism in mice.	FMR1 FXR2	5.63e-06	2	83	2	25552647
Pubmed	Competitive binding of E3 ligases TRIM26 and WWP2 controls SOX2 in glioblastoma.	PARP4 DNAJC13 EIF4A3 ABCD3 PDCD11 PSMD2 RPA1 GDI2 PRRC2B MEX3C	9.79e-06	732	83	10	34732716
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	TRPM6 CYLD FXR1 SETX AP1G1 MAP4 ZBTB41 RBM28 CDCP1 RPA1 CNOT2 PRDM2	9.99e-06	1084	83	12	11544199
Pubmed	Proteomic and functional analysis of Argonaute-containing mRNA-protein complexes in human cells.	FXR1 FMR1 FXR2 EIF4A3	1.08e-05	57	83	4	17932509
Pubmed	Dependence of Human Colorectal Cells Lacking the FBW7 Tumor Suppressor on the Spindle Assembly Checkpoint.	CYLD EFHC1 COL12A1 EIF4A3 COPS3	1.10e-05	121	83	5	26354767
Pubmed	An improved smaller biotin ligase for BioID proximity labeling.	YEATS2 MAP4 LIN54 MDC1 EMSY	1.19e-05	123	83	5	26912792
Pubmed	Systematically defining selective autophagy receptor-specific cargo using autophagosome content profiling.	BPTF DNAJC13 COL12A1 SETX DSG2 FXR2 EIF4A3 NOA1 MDC1 PDCD11 PSMD2 RPA1 PRRC2B	1.19e-05	1297	83	13	33545068
Pubmed	BAP1 regulation of the key adaptor protein NCoR1 is critical for γ-globin gene repression.	YEATS2 FXR1 MAP4 FXR2 EIF4A3 LIN54 ABCD3 PDCD11 PSMD2 RBM28 RPA1 LAP3 EMSY	1.41e-05	1318	83	13	30463901
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	YEATS2 BPTF RNF169 DNAJC13 SSH1 MAP4 XPO6 MDC1 EMSY PRDM2	1.58e-05	774	83	10	15302935
Pubmed	WWP2 ubiquitylates RNA polymerase II for DNA-PK-dependent transcription arrest and repair at DNA breaks.	DNAJC13 FXR1 SETX FMR1 MAP4 FXR2 EIF4A3 RBM28 PRRC2B	1.64e-05	615	83	9	31048545
Pubmed	The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.	YEATS2 BPTF RNF169 SETX MAP4 EIF4A3 LIN54 MDC1 PDCD11 RBM28 EMSY	1.67e-05	954	83	11	36373674
Pubmed	Identification of a novel protein from glial cells based on its ability to interact with NF-kappaB subunits.	NFKB1 PDCD11	1.69e-05	3	83	2	14624448
Pubmed	Fragile X Proteins FMRP and FXR2P Control Synaptic GluA1 Expression and Neuronal Maturation via Distinct Mechanisms.	FMR1 FXR2	1.69e-05	3	83	2	26051932
Pubmed	NIK and IKKbeta interdependence in NF-kappaB signalling--flux analysis of regulation through metabolites.	NFKB1 CHUK	1.69e-05	3	83	2	19909783
Pubmed	HTLV-1 tax-induced rapid senescence is driven by the transcriptional activity of NF-κB and depends on chronically activated IKKα and p65/RelA.	NFKB1 CHUK	1.69e-05	3	83	2	22740410
Pubmed	The IkappaB kinase complex and NF-kappaB act as master regulators of lipopolysaccharide-induced gene expression and control subordinate activation of AP-1.	NFKB1 CHUK	1.69e-05	3	83	2	15226448
Pubmed	Spatiotemporal expression of retrogene-host pair Mcts2/H13 in mouse embryo, and Mcts2 has no influence on H13 transcription pattern in NIH/3T3 cells.	MCTS2 MCTS1	1.69e-05	3	83	2	24063864
Pubmed	HIV-1 Vpr protein activates the NF-κB pathway to promote G2/M cell cycle arrest.	NFKB1 CHUK	1.69e-05	3	83	2	26676942
Pubmed	Biologic sequelae of I{kappa}B kinase (IKK) inhibition in multiple myeloma: therapeutic implications.	NFKB1 CHUK	1.69e-05	3	83	2	19270264
Pubmed	AMPK limits IL-1-stimulated IL-6 synthesis in osteoblasts: involvement of IκB/NF-κB pathway.	NFKB1 CHUK	1.69e-05	3	83	2	22560875
Pubmed	Cytosolic Hsp60 is involved in the NF-kappaB-dependent survival of cancer cells via IKK regulation.	NFKB1 CHUK	1.69e-05	3	83	2	20351780
Pubmed	Direct phosphorylation of NF-kappaB1 p105 by the IkappaB kinase complex on serine 927 is essential for signal-induced p105 proteolysis.	NFKB1 CHUK	1.69e-05	3	83	2	11297557
Pubmed	Human Caspase 12 Enhances NF-κB Activity through Activation of IKK in Nasopharyngeal Carcinoma Cells.	NFKB1 CHUK	1.69e-05	3	83	2	33924755
Pubmed	miR‑379 inhibits cell proliferation and epithelial‑mesenchymal transition by targeting CHUK through the NF‑κB pathway in non‑small cell lung cancer.	NFKB1 CHUK	1.69e-05	3	83	2	31173238
Pubmed	FXR2P Exerts a Positive Translational Control and Is Required for the Activity-Dependent Increase of PSD95 Expression.	FMR1 FXR2	1.69e-05	3	83	2	26109663
Pubmed	Increased IkappaB alpha expression is essential for the tolerogenic property of TGF-beta-exposed APCs.	NFKB1 CHUK	1.69e-05	3	83	2	19237504
Interaction	CECR2 interactions	CYLD FXR1 FMR1 FXR2 PRRC2B	1.19e-06	46	82	5	int:CECR2
Interaction	CNOT1 interactions	FXR1 FMR1 FXR2 CT55 RPA1 MEX3B CNOT2 PRRC2B MEX3C	4.12e-06	305	82	9	int:CNOT1
Interaction	RNF214 interactions	FXR1 FMR1 FXR2 MEX3B CNOT2 PRRC2B	4.16e-06	104	82	6	int:RNF214
Interaction	UBAP2 interactions	EFHC1 FXR1 FMR1 FXR2 RPA1 MEX3B CNOT2	6.00e-06	170	82	7	int:UBAP2
Interaction	SRPK2 interactions	EGLN2 FXR1 FMR1 MAP4 FXR2 EIF4A3 MDC1 PDCD11 HERC3 RBM28 RPA1 PRRC2B CHUK	6.10e-06	717	82	13	int:SRPK2
Interaction	CCAR2 interactions	CYLD FXR1 FMR1 FXR2 EIF4A3 PSMD2 RPA1 EMSY MEX3C	9.21e-06	337	82	9	int:CCAR2
Interaction	AGO1 interactions	CYLD FXR1 FMR1 FXR2 EIF4A3 MEX3B CNOT2	9.72e-06	183	82	7	int:AGO1
Interaction	SUZ12 interactions	BPTF FXR1 SETX FMR1 FXR2 EIF4A3 NFKB1 MCTS1 PDCD11 PLCD4 RPA1 MEX3B	1.10e-05	644	82	12	int:SUZ12
Interaction	EED interactions	BPTF TSC22D1 FXR1 SETX AP1G1 DSG2 XIRP2 FXR2 EIF4A3 MDC1 ABCD3 PDCD11 PSMD2 COPS3 RBM28 RPA1 GDI2 PRDM2	1.60e-05	1445	82	18	int:EED
Interaction	TNRC6B interactions	CYLD FXR1 FMR1 FXR2 RPA1 MEX3B CNOT2 PRRC2B	1.94e-05	282	82	8	int:TNRC6B
Interaction	CNOT3 interactions	FMR1 MAP4 FXR2 RPA1 MEX3B CNOT2 MEX3C	2.16e-05	207	82	7	int:CNOT3
Interaction	CNOT7 interactions	NFKB1 RPA1 MEX3B CNOT2 PRRC2B MEX3C	2.29e-05	140	82	6	int:CNOT7
Interaction	USP10 interactions	CYLD FXR1 FMR1 MAP4 FXR2 TRPM8 RPA1 MEX3B	2.37e-05	290	82	8	int:USP10
Interaction	TDRD3 interactions	FXR1 FMR1 FXR2 EIF4A3 MEX3B CNOT2 PRRC2B	2.52e-05	212	82	7	int:TDRD3
Interaction	ZC3H7A interactions	FXR1 FMR1 FXR2 RPA1 MEX3B CNOT2 PRRC2B	2.75e-05	215	82	7	int:ZC3H7A
Interaction	MEX3B interactions	FXR1 FMR1 FXR2 MEX3B CNOT2 PRRC2B MEX3C	3.38e-05	222	82	7	int:MEX3B
Interaction	CD6 interactions	FXR1 FMR1 FXR2 APTX PDCD11 ZMYM6	3.92e-05	154	82	6	int:CD6
Interaction	YTHDF2 interactions	CYLD FXR1 FMR1 FXR2 RPA1 MEX3B CNOT2 PRRC2B	3.98e-05	312	82	8	int:YTHDF2
Interaction	UNK interactions	TSC22D1 FMR1 AP1G1 FXR2 ABCD3 COPS3 GDI2 CNOT2 PRRC2B	4.16e-05	408	82	9	int:UNK
Interaction	CPEB4 interactions	FXR1 FMR1 FXR2 MEX3B CNOT2 PRRC2B	4.21e-05	156	82	6	int:CPEB4
Interaction	GSK3B interactions	CYLD DNAJC13 FXR1 FMR1 DSG2 MAP4 XPO6 NFKB1 PDCD11 PSMD2 RBM28 RPA1 GDI2	4.56e-05	868	82	13	int:GSK3B
Interaction	SMG7 interactions	YEATS2 FXR1 FMR1 FXR2 RPA1 MEX3B CNOT2 PRRC2B	4.66e-05	319	82	8	int:SMG7
Interaction	SMG1 interactions	FXR1 FMR1 FXR2 EIF4A3 MEX3B	4.74e-05	97	82	5	int:SMG1
Interaction	AURKB interactions	CYLD DNAJC13 FXR1 SETX FMR1 NFKB1 MDC1 PSMD2 RBM28 CPS1 RALGAPA2 RPA1	5.64e-05	761	82	12	int:AURKB
Interaction	KLF8 interactions	YEATS2 BPTF LIN54 PSMD2 RBM28 EMSY PRRC2B PRDM2	5.78e-05	329	82	8	int:KLF8
Interaction	YTHDF3 interactions	FXR1 FMR1 FXR2 RPA1 MEX3B CNOT2 PRRC2B	6.47e-05	246	82	7	int:YTHDF3
Interaction	ASF1A interactions	YEATS2 RNF169 LIN54 MDC1 EMSY ZMYM6 PRDM2	6.98e-05	249	82	7	int:ASF1A
Interaction	PNMA2 interactions	CYLD SETX NOA1 PLCD4 DSG4 ZMYM6 PRRC2B	7.34e-05	251	82	7	int:PNMA2
Interaction	CNOT11 interactions	NFKB1 CT55 RPA1 MEX3B CNOT2	9.41e-05	112	82	5	int:CNOT11
Interaction	PHC1P1 interactions	FXR1 FXR2	9.76e-05	4	82	2	int:PHC1P1
Interaction	PRRC2B interactions	FXR1 FMR1 FXR2 RPA1 MEX3B CNOT2 PRRC2B	1.03e-04	265	82	7	int:PRRC2B
Interaction	DCTPP1 interactions	FXR1 FMR1 FXR2 NOA1	1.04e-04	60	82	4	int:DCTPP1
Interaction	RNF123 interactions	CFAP47 PARP4 SETX FXR2 NFKB1 ABCD3 ZBTB41 RBM28 RPA1 SSPOP DNAH14 PRDM2	1.20e-04	824	82	12	int:RNF123
Interaction	CEBPA interactions	YEATS2 BPTF SETX MAP4 EIF4A3 LIN54 MCTS1 PDCD11 COPS3 RBM28 RPA1 GDI2 EMSY PRRC2B PRDM2	1.33e-04	1245	82	15	int:CEBPA
Interaction	HNRNPAB interactions	CYLD FMR1 MAP4 MDC1 MCTS1 RALGAPA2 RPA1 DNAH14	1.33e-04	371	82	8	int:HNRNPAB
Interaction	IKZF5 interactions	YEATS2 LIN54 ZNF518B DNAH14	1.43e-04	65	82	4	int:IKZF5
Interaction	CSDE1 interactions	CYLD FXR1 FMR1 MAP4 RPA1 MEX3B PRRC2B	1.58e-04	284	82	7	int:CSDE1
Interaction	ELF1 interactions	BPTF LIN54 NFKB1 RBM28 EMSY	1.64e-04	126	82	5	int:ELF1
Interaction	PRRC2A interactions	CYLD FXR1 FMR1 FXR2 RPA1 MEX3B CNOT2 PRRC2B	1.84e-04	389	82	8	int:PRRC2A
Interaction	RBMS1 interactions	FXR1 FMR1 FXR2 MEX3B CNOT2 PRRC2B	2.00e-04	207	82	6	int:RBMS1
Interaction	HERC2 interactions	CYLD FXR1 FMR1 MAP4 EIF4A3 MDC1 PSMD2 HERC3 RPA1	2.04e-04	503	82	9	int:HERC2
Interaction	SIRT7 interactions	BPTF FXR1 FMR1 MAP4 FXR2 MDC1 PDCD11 PSMD2 RBM28 GDI2 PRRC2B	2.07e-04	744	82	11	int:SIRT7
Interaction	FUBP3 interactions	FXR1 FMR1 FXR2 RPA1 MEX3B CNOT2 PRRC2B	2.08e-04	297	82	7	int:FUBP3
Interaction	SLC4A1AP interactions	CYLD MAP4 MDC1 PSMD2 RPA1	2.11e-04	133	82	5	int:SLC4A1AP
Interaction	UBAP2L interactions	YEATS2 FXR1 FMR1 FXR2 MEX3B CNOT2 PRRC2B	2.12e-04	298	82	7	int:UBAP2L
Interaction	NUP43 interactions	YEATS2 BPTF SETX MAP4 LIN54 MDC1 PDCD11 RBM28 EMSY PRDM2	2.20e-04	625	82	10	int:NUP43
Interaction	EIF4ENIF1 interactions	EFHC1 FXR1 FMR1 FXR2 MEX3B CNOT2 PRRC2B	2.21e-04	300	82	7	int:EIF4ENIF1
Interaction	YTHDF1 interactions	FXR1 FMR1 FXR2 RPA1 MEX3B CNOT2 PRRC2B	2.30e-04	302	82	7	int:YTHDF1
Interaction	RPS20 interactions	CYLD FXR1 FMR1 MAP4 FXR2 MCTS1 RPA1 CNOT2 PRRC2B	2.36e-04	513	82	9	int:RPS20
Interaction	MAPKBP1 interactions	FXR1 MAP4 FXR2 APTX	2.36e-04	74	82	4	int:MAPKBP1
Interaction	TRIM56 interactions	CYLD FXR1 FMR1 FXR2 MEX3B	2.42e-04	137	82	5	int:TRIM56
Interaction	RABAC1 interactions	SYT16 FXR1 FXR2 KDSR RPA1	2.42e-04	137	82	5	int:RABAC1
Interaction	ANKHD1 interactions	FXR1 EIF4A3 RPA1 MEX3B CNOT2 PRRC2B	2.51e-04	216	82	6	int:ANKHD1
Interaction	BLTP3B interactions	FXR1 FMR1 CT55 RPA1	2.75e-04	77	82	4	int:BLTP3B
Interaction	CNOT10 interactions	FXR2 CT55 RPA1 MEX3B CNOT2	2.76e-04	141	82	5	int:CNOT10
Interaction	ATXN2 interactions	FXR1 FMR1 FXR2 MDC1 RPA1 MEX3B PRRC2B	2.81e-04	312	82	7	int:ATXN2
Interaction	CAMK2D interactions	CYLD FMR1 FXR2 LIN54 RPA1 DNAH14	2.91e-04	222	82	6	int:CAMK2D
Interaction	WDR6 interactions	NFKB1 PDCD11 COPS3 RBM28 RPA1 MEX3B MEX3C	2.92e-04	314	82	7	int:WDR6
Interaction	PUM2 interactions	FMR1 RPA1 MEX3B CNOT2 PRRC2B	3.05e-04	144	82	5	int:PUM2
Interaction	KIF20A interactions	FXR1 SETX FMR1 DSG2 FXR2 EIF4A3 MDC1 ABCD3 HERC3 CPS1 RALGAPA2 EMSY PRRC2B	3.09e-04	1052	82	13	int:KIF20A
Interaction	TP53BP1 interactions	RNF169 FXR1 SETX FMR1 NFKB1 MDC1 PSMD2 RPA1 EMSY	3.12e-04	533	82	9	int:TP53BP1
Interaction	EDC4 interactions	YEATS2 FXR1 FMR1 FXR2 RPA1 MEX3B	3.20e-04	226	82	6	int:EDC4
Interaction	ANKRD17 interactions	FXR1 FMR1 FXR2 MEX3B CNOT2 PRRC2B	3.20e-04	226	82	6	int:ANKRD17
Interaction	EML1 interactions	FXR1 FMR1 RPA1	3.24e-04	33	82	3	int:EML1
Interaction	FMR1 interactions	CYLD EFHC1 FXR1 FMR1 FXR2 EIF4A3 MEX3B EMSY PRRC2B	3.25e-04	536	82	9	int:FMR1
Interaction	DENR interactions	EIF4A3 MCTS1 COPS3 RPA1	3.34e-04	81	82	4	int:DENR
Interaction	AP2M1 interactions	CYLD FXR1 AP1G1 MAP4 FXR2 RPA1 MEX3B MEX3C	3.61e-04	430	82	8	int:AP2M1
Interaction	FBXW7 interactions	CYLD EGLN2 DNAJC13 EFHC1 COL12A1 FXR1 FMR1 AP1G1 MAP4 EIF4A3 NFKB1 ABCD3 COPS3 RBM28	3.62e-04	1215	82	14	int:FBXW7
Interaction	GLE1 interactions	FXR1 FMR1 FXR2 MEX3B MEX3C	3.68e-04	150	82	5	int:GLE1
Interaction	TNIP1 interactions	FXR1 FMR1 DSG2 MAP4 FXR2 EIF4A3 NFKB1 MDC1 ABCD3 PDCD11 PSMD2 RBM28 CPS1 RPA1	3.68e-04	1217	82	14	int:TNIP1
Interaction	RC3H2 interactions	FXR1 FMR1 FXR2 EIF4A3 PDCD11 PSMD2 RBM28 MEX3B CNOT2 PRRC2B	3.69e-04	667	82	10	int:RC3H2
Interaction	R3HDM1 interactions	FXR1 FMR1 MEX3B PRRC2B	3.84e-04	84	82	4	int:R3HDM1
Interaction	SMG6 interactions	FXR1 FMR1 EIF4A3 PRRC2B	4.01e-04	85	82	4	int:SMG6
Interaction	OTUD4 interactions	CYLD FXR1 FMR1 FXR2 MEX3B PRRC2B	4.03e-04	236	82	6	int:OTUD4
Interaction	RC3H1 interactions	RNF169 FXR1 FMR1 FXR2 NOA1 PDCD11 RBM28 MEX3B CNOT2 PRRC2B	4.14e-04	677	82	10	int:RC3H1
Interaction	CLEC14A interactions	FXR1 FMR1 FXR2 EIF4A3	4.20e-04	86	82	4	int:CLEC14A
Interaction	SPATA2 interactions	CYLD EFHC1 MEX3B CHUK	4.38e-04	87	82	4	int:SPATA2
Interaction	N4BP2 interactions	FXR1 FMR1 RPA1 CNOT2	4.78e-04	89	82	4	int:N4BP2
Interaction	TAX1BP1 interactions	BPTF DNAJC13 COL12A1 MDC1 RPA1 PRRC2B CHUK	4.87e-04	342	82	7	int:TAX1BP1
Interaction	ZBTB2 interactions	FXR1 FMR1 FXR2 MDC1 MCTS1 ABCD3 PDCD11 RBM28	4.88e-04	450	82	8	int:ZBTB2
Interaction	CCN3 interactions	FXR1 FXR2 NFKB1	4.94e-04	38	82	3	int:CCN3
Interaction	CAPRIN1 interactions	CYLD FXR1 FMR1 FXR2 ANKRD36 RPA1 MEX3B PRRC2B	4.95e-04	451	82	8	int:CAPRIN1
Interaction	YY1 interactions	YEATS2 BPTF LIN54 NFKB1 MDC1 RBM28 RPA1 EMSY	5.18e-04	454	82	8	int:YY1
Interaction	SLX4 interactions	YEATS2 RNF169 EIF4A3 MDC1 PDCD11 ZNF518B RPA1 EMSY PRRC2B	5.21e-04	572	82	9	int:SLX4
Interaction	DHX40 interactions	DNAJC13 PDCD11 RBM28 RPA1 PRDM2 CHUK	5.36e-04	249	82	6	int:DHX40
Interaction	PRC1 interactions	FXR1 FMR1 DSG2 FXR2 EIF4A3 MDC1 ABCD3 PDCD11 PSMD2 RBM28 CPS1 RPA1	5.48e-04	973	82	12	int:PRC1
Interaction	G3BP1 interactions	CYLD FXR1 FMR1 MAP4 FXR2 PDCD11 PSMD2 RPA1 MEX3B CNOT2 PRRC2B	5.52e-04	835	82	11	int:G3BP1
Interaction	LSM12 interactions	FXR1 FMR1 FXR2 MDC1 MEX3B	5.53e-04	164	82	5	int:LSM12
Interaction	RHEB interactions	MAP2 MAP4 RPA1 CNOT2 LAP3	5.53e-04	164	82	5	int:RHEB
Interaction	CNOT6L interactions	NFKB1 MEX3B CNOT2 PRRC2B	5.65e-04	93	82	4	int:CNOT6L
Interaction	MAD2L1 interactions	YEATS2 BPTF SETX LIN54 MDC1 RPA1	5.70e-04	252	82	6	int:MAD2L1
Interaction	H1-5 interactions	SYT16 FXR1 MAP4 XIRP2 VSIG1 RBM28 TMEM35B EMSY	5.89e-04	463	82	8	int:H1-5
Interaction	SERBP1 interactions	CYLD FXR1 FMR1 AP1G1 DSG2 MAP4 FXR2 EIF4A3 MDC1 PSMD2 COPS3 RPA1 CNOT2 LAP3 PRRC2B	5.98e-04	1432	82	15	int:SERBP1
Interaction	TNKS1BP1 interactions	CYLD NFKB1 RPA1 MEX3B CNOT2	6.17e-04	168	82	5	int:TNKS1BP1
Interaction	MVP interactions	CYLD PARP4 FXR1 FMR1 FXR2	6.17e-04	168	82	5	int:MVP
Interaction	HELZ interactions	FXR1 FXR2 RPA1 MEX3B CNOT2 PRRC2B	6.32e-04	257	82	6	int:HELZ
Interaction	AGO2 interactions	FXR1 FMR1 FXR2 CPS1 RPA1 MEX3B CNOT2 PRRC2B	6.68e-04	472	82	8	int:AGO2
Interaction	LSM14A interactions	FXR1 FMR1 FXR2 MEX3B CNOT2 PRRC2B	6.72e-04	260	82	6	int:LSM14A
Interaction	GIT1 interactions	FXR1 FMR1 CEP126 RPA1 MEX3B	6.86e-04	172	82	5	int:GIT1
Interaction	NCOR1 interactions	BPTF FXR1 FMR1 NFKB1 RPA1 CNOT2 CHUK	6.93e-04	363	82	7	int:NCOR1
Cytoband	6q12-q13	COL12A1 COL19A1	3.30e-05	5	84	2	6q12-q13
Cytoband	9q34.13	SETX PRRC2B	6.79e-04	21	84	2	9q34.13
Cytoband	18q12.1	DSG2 DSG4	1.04e-03	26	84	2	18q12.1
Cytoband	3q27.1	YEATS2 PSMD2	1.13e-03	27	84	2	3q27.1
GeneFamily	Desmosomal cadherins	DSG2 DSG4	1.69e-04	7	52	2	1188
GeneFamily	Collagens	COL12A1 COL19A1 COL6A6	3.12e-04	46	52	3	490
ToppCell	wk_20-22-Mesenchymal-Chondrocyte-intermediate_chondrocyte\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	FBXL22 PDE8A COL6A6 MAP2 ADAMTSL3 DNAH14	1.30e-06	183	84	6	1464b5c4425e8776c4aeb4d2b560481d4bf13931
Drug	lead compounds	FXR1 FMR1 FXR2 NFKB1 PLCD4 RPA1 CHUK	1.18e-06	150	82	7	CID000073212
Disease	malignant pleural mesothelioma (implicated_via_orthology)	FXR1 FMR1 FXR2	1.99e-08	3	81	3	DOID:7474 (implicated_via_orthology)
Disease	fragile X syndrome (implicated_via_orthology)	FXR1 FMR1 FXR2	1.99e-08	3	81	3	DOID:14261 (implicated_via_orthology)
Disease	SPINOCEREBELLAR ATAXIA, AUTOSOMAL RECESSIVE 1	SETX APTX	2.23e-05	3	81	2	C1853761
Disease	atopic eczema, childhood onset asthma, atopic march	EFHC1 EMSY	4.03e-04	11	81	2	EFO_0000274, EFO_0007755, MONDO_0005405
Disease	eosinophil percentage of granulocytes	BPTF NFKB1 PSMD2 CPS1 EMSY	4.72e-04	234	81	5	EFO_0007996
Disease	banks of the superior temporal sulcus volume measurement	AP1G1 PGBD5	9.85e-04	17	81	2	EFO_0010286
Disease	Intellectual Disability	BPTF FMR1 TMEM94 EIF4A3 RBM28 ZMYM6	1.46e-03	447	81	6	C3714756

Protein segments in the cluster

Peptide	Gene	Start	Entry
GKVQQLPKYTSQIVG	COPS3	236	Q9UNS2
GGSIKQIQVKQNISV	CDCP1	501	Q9H5V8
NKGYVKVKQVGVNPT	APTX	66	Q7Z2E3
VIGKDQEVKLQPGQV	APTX	86	Q7Z2E3
ILKQEGGVVINKPIA	AP4B1	186	Q9Y6B7
IKDGQIRGTVSPQKQ	ANKRD36	1216	A6QL64
GVVQVQQKVLGIIPS	BPTF	2126	Q12830
ILQPGKKIQGGTEIQ	LINC02877	71	P0CE67
PVQCQLKGKGVINDV	ATP1B4	326	Q9UN42
QVGPVKQCFVVTEKG	RBM28	26	Q9NW13
GTITQVIKVLNPQKQ	AP1G1	776	O43747
PGDVVRAKNGKTIQV	LAP3	346	P28838
GEVTDKPVKQAQVQI	DSG2	246	Q14126
GNVPLKVGQKVNVVV	CT55	66	Q8WUE5
LNKPIEEIIVQNGKV	GDI2	251	P50395
QQIKVVTIGGRPEVK	LIN54	181	Q6MZP7
VIKGIKNQLIEQFPG	MCTS1	21	Q9ULC4
VIKGIKSQLVEQFPG	MCTS2	21	A0A3B3IRV3
QPQRGEVSQKTVIIK	MDC1	1826	Q14676
IASAQKQPAGKVQIV	MAP4	981	P27816
VQVPRNLVGKVIGKN	FXR2	296	P51116
IQVPRNLVGKVIGKN	FXR1	286	P51114
VIEQKKLIPGGDNVT	HERC3	866	Q15034
KPENIVLQDVGGKII	CHUK	146	O15111
KDVKIGLNIGQAIVN	KIAA2026	1571	Q5HYC2
VNEVIQKVSGGEQPI	KIAA1109	3121	Q2LD37
PQDVQKTVLKGIINS	HECTD2	201	Q5U5R9
PSAIQQRAIKQIIKG	EIF4A3	61	P38919
QTDPQTNEGILKVVK	DSG4	321	Q86SJ6
VTTLNQKINKGPVDV	PLXNC1	1161	O60486
QQNVKIIPVIGQGGK	PDE8A	301	O60658
VGEKQKVNIIQFGTG	PARP4	906	Q9UKK3
QNTKNGVDVLPKIIQ	RALGAPA2	321	Q2PPJ7
PVQQGVIIKRKSGEI	PGBD5	421	Q8N414
KGDTNIKPILQVINI	RPA1	16	P27694
KIPQKGILIGIQQSF	CPS1	1356	P31327
IQVPRNLVGKVIGKN	FMR1	286	Q06787
IGGRQNSVVLQKLKP	COL12A1	1801	Q99715
QNIPQISIVVDGGKK	COL19A1	126	Q14993
KVNIFTQAQGKLIIP	CEP126	786	Q9P2H0
GIAQKENINQKPVVL	DNAJC13	731	O75165
VQKVVGPKQIQVAEA	DNAH14	2461	Q0VDD8
PVVENSGILQGKLIK	EFHC1	136	Q5JVL4
IIPTKIVYGQQGKTQ	EMSY	651	Q7Z589
IVYGQQGKTQVLIKP	EMSY	656	Q7Z589
KYQLASGQKGVQVPV	EGLN2	386	Q96KS0
KNEKVGVPTIQQLLE	CYLD	721	Q9NQC7
GTQIIPFVIKNKGIT	CFAP47	1071	Q6ZTR5
VENVIKQAQEKLGPV	KDSR	101	Q06136
ALVGPKQLIVLGNKV	NOA1	236	Q8NC60
KSQIGPDRVQIGVVQ	COL6A6	651	A6NMZ7
VPLKQTVQPKNGVVV	PRDM2	1371	Q13029
IEKQIQSKGPGITER	PANX2	176	Q96RD6
VGPKGATIKRIQQQT	MEX3B	176	Q6ZN04
GQVPLIIQKCVGQIE	SYDE1	411	Q6ZW31
LIQAGNVSVKGQLVP	SSPOP	256	A2VEC9
IQVISGQQLPKVDKT	PLCD4	631	Q9BRC7
KVICVRVNVGQVGPK	THSD7A	736	Q9UPZ6
QLPGTLETVNGKKQV	SYT16	161	Q17RD7
GNNIKPVVKVSIAGQ	FER1L5	181	A0AVI2
VGQAVDVVGQAGKPK	PSMD2	846	Q13200
PVVISVKQEEGKQGR	FBXL22	201	Q6P050
VVGPKGATIKRIQQQ	MEX3C	341	Q5U5Q3
KEVQGRPQKTQSIII	SETX	2131	Q7Z333
VLPQNSVLGGVLKTK	RNF169	576	Q8NCN4
GVLINKVVETVKQNP	TSC22D1	441	Q15714
LQKQGLLQVTPKGFI	SLC26A3	581	P40879
GKPGLVKQRTQEIET	SSH1	946	Q8WYL5
VSQQEKGIEGVQVIP	ABCD3	411	P28288
QKKGIQVLPDGRVTN	CNOT2	331	Q9NZN8
AVKLQTVKQEEIQGG	XIRP2	971	A4UGR9
GLVVKAQVQKVTPFG	PDCD11	281	Q14690
NVGQLLAQTKKVVRP	TMEM35B	126	Q8NCS4
GQNQGILNVSVLVKP	VSIG1	126	Q86XK7
KKNTQGLQVPIITVN	TRPM6	1586	Q9BX84
QLNGKCIELVQVPGQ	TMEM94	761	Q12767
EGLTPVVIQNSNKKI	ZBTB41	346	Q5SVQ8
KEQAVQVPVKGRGLS	PRRC2B	1581	Q5JSZ5
QPKGGQVQIVTKKID	MAP2	1686	P11137
VQQPKTQESKLKIGG	ZMYM6	36	O95789
KNKIPCVVVEGSGQI	TRPM8	321	Q7Z2W7
KFLKILQVVVQEPGQ	XPO6	891	Q96QU8
QVKQSPQSLIVQKGG	TRAV23DV6	31	A0A075B6W5
PQSLIVQKGGISIIN	TRAV23DV6	36	A0A075B6W5
AVGPKQVVTQGVAKA	YEATS2	686	Q9ULM3
KVVNGTQQLVLKLFP	ZNF518B	351	Q9C0D4
GKIQIQNPTRKEQGI	ADAMTSL3	1246	P82987
QTIQKKVGEPVNLLI	MYBPC3	981	Q14896
GPAKVIVQLVTNGKN	NFKB1	91	P19838