Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionenzyme-substrate adaptor activity

KLHDC1 A1CF PRAMEF5 PRAMEF9 NMNAT1 PRAMEF15 PRAMEF4 KLHDC10 PRAMEF26 PRAMEF27 PRAMEF6

6.89e-13959311GO:0140767
GeneOntologyMolecularFunctionubiquitin-like ligase-substrate adaptor activity

KLHDC1 PRAMEF5 PRAMEF9 PRAMEF15 PRAMEF4 KLHDC10 PRAMEF26 PRAMEF27 PRAMEF6

1.54e-1082939GO:1990756
GeneOntologyMolecularFunctionnuclear retinoic acid receptor binding

PRAMEF5 PRAMEF15 PRAMEF4 PRAMEF26 PRAMEF27 PRAMEF6

2.09e-0755936GO:0042974
GeneOntologyMolecularFunctionprotein-macromolecule adaptor activity

SHANK1 SRRT KLHDC1 A1CF PRAMEF5 PRAMEF9 NMNAT1 PRAMEF15 LRRK2 NUP98 MED14 NBN PRAMEF4 CTNNB1 KLHDC10 PRAMEF26 PRAMEF27 TP53BP1 PRAMEF6

1.34e-0611609319GO:0030674
GeneOntologyMolecularFunctionnuclear receptor binding

PRAMEF5 PRAMEF15 MED14 PRAMEF4 CTNNB1 PRAMEF26 PRAMEF27 PRAMEF6

2.63e-06187938GO:0016922
GeneOntologyMolecularFunctionDNA-binding transcription factor binding

PRAMEF5 PRAMEF15 MED14 NBN PRAMEF4 CTNNB1 USF1 USF2 PRAMEF26 PRAMEF27 TP53 TP53BP1 PRAMEF6

2.94e-065829313GO:0140297
GeneOntologyMolecularFunctionmolecular adaptor activity

SHANK1 SRRT KLHDC1 A1CF PRAMEF5 PRAMEF9 NMNAT1 PRAMEF15 ITSN2 LRRK2 NUP98 MED14 NBN PRAMEF4 CTNNB1 KLHDC10 PRAMEF26 PRAMEF27 TP53BP1 PRAMEF6

3.38e-0613569320GO:0060090
GeneOntologyMolecularFunctionRNA polymerase II-specific DNA-binding transcription factor binding

PRAMEF5 PRAMEF15 MED14 PRAMEF4 CTNNB1 PRAMEF26 PRAMEF27 TP53 TP53BP1 PRAMEF6

2.44e-054179310GO:0061629
GeneOntologyMolecularFunctiontranscription factor binding

PRAMEF5 PRAMEF15 MED14 NBN PRAMEF4 CTNNB1 USF1 USF2 PRAMEF26 PRAMEF27 TP53 TP53BP1 PRAMEF6

4.52e-057539313GO:0008134
GeneOntologyBiologicalProcesspositive regulation of synaptic vesicle recycling

PLAA ABCA13 LRRK2

5.76e-0517933GO:1903423
GeneOntologyBiologicalProcessoogenesis

PRAMEF5 PRAMEF15 ZNF830 PRAMEF4 CTNNB1 PRAMEF6

7.53e-05156936GO:0048477
GeneOntologyBiologicalProcessoocyte development

PRAMEF5 PRAMEF15 PRAMEF4 CTNNB1 PRAMEF6

8.56e-0599935GO:0048599
GeneOntologyBiologicalProcessstem cell population maintenance

SRRT PRAMEF5 PRAMEF15 MED14 PRAMEF4 CTNNB1 PRAMEF6

9.91e-05237937GO:0019827
GeneOntologyBiologicalProcessoocyte differentiation

PRAMEF5 PRAMEF15 PRAMEF4 CTNNB1 PRAMEF6

1.03e-04103935GO:0009994
GeneOntologyBiologicalProcessmaintenance of cell number

SRRT PRAMEF5 PRAMEF15 MED14 PRAMEF4 CTNNB1 PRAMEF6

1.13e-04242937GO:0098727
GeneOntologyBiologicalProcesslate viral transcription

USF1 USF2

1.20e-044932GO:0019086
GeneOntologyBiologicalProcesssomatic stem cell population maintenance

PRAMEF5 PRAMEF15 MED14 PRAMEF4 PRAMEF6

1.29e-04108935GO:0035019
GeneOntologyBiologicalProcessnegative regulation of cell differentiation

PRTG PRAMEF25 PRAMEF5 PRAMEF9 IPO7 PRAMEF15 NBN PRAMEF4 CTNNB1 PRAMEF26 PRAMEF27 TP53 PRAMEF6

1.48e-048759313GO:0045596
GeneOntologyBiologicalProcessnegative regulation of apoptotic process

PRAMEF25 PRAMEF5 PRAMEF9 NMNAT1 GCLM PRAMEF15 LRRK2 ABCC9 ZNF830 PRAMEF4 CTNNB1 PRAMEF26 PRAMEF27 TP53 PRAMEF6

1.58e-0411339315GO:0043066
GeneOntologyBiologicalProcessblastocyst development

PRAMEF5 PRAMEF15 NBN ZNF830 PRAMEF4 PRAMEF6

1.60e-04179936GO:0001824
GeneOntologyBiologicalProcessnegative regulation of programmed cell death

PRAMEF25 PRAMEF5 PRAMEF9 NMNAT1 GCLM PRAMEF15 LRRK2 ABCC9 ZNF830 PRAMEF4 CTNNB1 PRAMEF26 PRAMEF27 TP53 PRAMEF6

2.26e-0411719315GO:0043069
GeneOntologyCellularComponentCul2-RING ubiquitin ligase complex

PRAMEF5 PRAMEF9 PRAMEF15 PRAMEF4 KLHDC10 PRAMEF26 PRAMEF27 PRAMEF6

3.08e-1147938GO:0031462
GeneOntologyCellularComponentcullin-RING ubiquitin ligase complex

KLHDC1 PRAMEF5 PRAMEF9 PRAMEF15 PRAMEF4 KLHDC10 PRAMEF26 PRAMEF27 PRAMEF6

4.41e-07212939GO:0031461
GeneOntologyCellularComponentubiquitin ligase complex

KLHDC1 PRAMEF5 PRAMEF9 PRAMEF15 PRAMEF4 KLHDC10 PRAMEF26 PRAMEF27 PRAMEF6

2.73e-05352939GO:0000151
GeneOntologyCellularComponentsynaptic membrane

SHANK1 MPP4 ITSN2 SLITRK5 GPR156 ADGRL1 SLITRK3 GRIN2C CTNNB1 ATP2B3

2.67e-045839310GO:0097060
GeneOntologyCellularComponentacrosomal vesicle

PRAMEF5 VEZT PRAMEF15 ABCC9 PRAMEF4 PRAMEF6

3.18e-04206936GO:0001669
MousePhenoabnormal spermatogonia proliferation

PRAMEF5 PRAMEF15 PRAMEF4 PRAMEF26 PRAMEF27 PRAMEF6

1.49e-0747736MP:0002685
MousePhenoabnormal tail morphology

PHEX RPL27A PARP4 PRAMEF5 PRAMEF15 PRAMEF4 CTNNB1 USF2 SVEP1 TP53 PRAMEF6

7.12e-064037311MP:0002111
MousePhenoabnormal cell proliferation

RPL27A A1CF CD4 CD5 PRAMEF5 GCLM PRAMEF15 NUP98 NBN ZNF830 PRAMEF4 CTNNB1 ESPL1 PRAMEF26 IL23A PRAMEF27 TP53 TP53BP1 PRAMEF6

2.49e-0512947319MP:0000350
MousePhenoabnormal male germ cell apoptosis

PRAMEF5 KCTD19 PRAMEF15 PRAMEF4 PRAMEF26 PRAMEF27 TP53 PRAMEF6

3.06e-05236738MP:0008280
MousePhenoenlarged urinary bladder

PRAMEF5 NHSL2 MICAL2 PRAMEF15 PRAMEF4 PRAMEF6

3.10e-05116736MP:0011874
MousePhenoabnormal male germ cell physiology

PRAMEF5 KCTD19 PRAMEF15 PRAMEF4 PRAMEF26 PRAMEF27 TP53 PRAMEF6

3.88e-05244738MP:0020362
MousePhenoincreased mortality induced by gamma-irradiation

RPL27A NBN TP53 TP53BP1

3.97e-0537734MP:0001658
MousePhenoabnormal urinary bladder morphology

PRAMEF5 IPO7 NHSL2 MICAL2 PRAMEF15 SLITRK5 PRAMEF4 PRAMEF6

4.23e-05247738MP:0000538
MousePhenoabsent gametes

PRAMEF5 KCTD19 PRAMEF15 NBN PRAMEF4 PRAMEF26 PRAMEF27 PRAMEF6

5.45e-05256738MP:0001117
MousePhenoincreased male germ cell apoptosis

PRAMEF5 KCTD19 PRAMEF15 PRAMEF4 PRAMEF26 PRAMEF27 PRAMEF6

5.67e-05189737MP:0014052
MousePhenoabnormal jejunum morphology

PRAMEF5 PRAMEF15 PRAMEF4 PRAMEF6

5.99e-0541734MP:0004002
MousePhenoabnormal germ cell physiology

PRAMEF5 KCTD19 PRAMEF15 PRAMEF4 PRAMEF26 PRAMEF27 TP53 PRAMEF6

7.33e-05267738MP:0020363
MousePhenoabnormal vitreous body morphology

SHANK1 PARP4 PRAMEF5 PRAMEF15 PRAMEF4 KLHDC10 PRAMEF26 PRAMEF27 TP53 PRAMEF6

7.36e-054297310MP:0002699
MousePhenoincreased mortality induced by ionizing radiation

RPL27A NBN TP53 TP53BP1

1.42e-0451734MP:0003992
MousePhenoincreased apoptosis

IL34 SRRT PRTG PRAMEF5 KCTD19 GCLM PRAMEF15 LRRK2 NBN PRAMEF4 CTNNB1 PRAMEF26 PRAMEF27 TP53 PRAMEF6

1.84e-0410087315MP:0006042
MousePhenoabnormal mortality induced by ionizing radiation

RPL27A NBN TP53 TP53BP1

1.91e-0455734MP:0020149
MousePhenoabnormal lymph node morphology

IL34 CD4 PRAMEF5 IPO7 NHSL2 MICAL2 PRAMEF15 SLITRK5 PRAMEF4 CTNNB1 TP53 PRAMEF6

1.99e-046837312MP:0002339
MousePhenoincreased cell death

IL34 SRRT PRTG PRAMEF5 KCTD19 GCLM PRAMEF15 LRRK2 NBN PRAMEF4 CTNNB1 PRAMEF26 PRAMEF27 TP53 PRAMEF6

2.08e-0410197315MP:0012556
MousePhenoabnormal response to radiation

RPL27A NBN TP53 TP53BP1

2.19e-0457734MP:0012734
MousePhenoazoospermia

PRAMEF5 KCTD19 PRAMEF15 PRAMEF4 PRAMEF26 PRAMEF27 PRAMEF6

2.77e-04244737MP:0005159
MousePhenoabnormal foot pad morphology

RPL27A CTNNB1 TP53

3.26e-0426733MP:0000574
MousePhenoabnormal duodenum morphology

PRAMEF5 PRAMEF15 PRAMEF4 PRAMEF6

3.43e-0464734MP:0003271
MousePhenosmall kidney

PARP4 PRAMEF5 MICAL2 PRAMEF15 LRRK2 IL17RC PRAMEF4 TP53 PRAMEF6

3.53e-04425739MP:0002989
MousePhenoabnormal coat/ hair morphology

SHANK1 KCTD19 VEZT BAZ2B ITSN2 LRRK2 SLITRK5 CTNNB1 USF2 ATP2B3 USP19 TP53 DOP1B

4.26e-048547313MP:0000367
MousePhenoabnormal lymph node size

IL34 PRAMEF5 IPO7 NHSL2 MICAL2 PRAMEF15 SLITRK5 PRAMEF4 CTNNB1 PRAMEF6

6.37e-045617310MP:0000701
MousePhenodecreased testis weight

PRAMEF5 KCTD19 PRAMEF15 PRAMEF4 PRAMEF26 PRAMEF27 TP53 PRAMEF6

6.70e-04370738MP:0004852
DomainPRAME_family

PRAMEF25 PRAMEF5 PRAMEF15 PRAMEF4 PRAMEF27 PRAMEF6

2.73e-1019906IPR026271
Domain-

LRRC39 PRAMEF25 PRAMEF5 PRAMEF15 LRRK2 SLITRK5 SLITRK3 PRAMEF4 PRAMEF27 PRAMEF6

3.32e-0632190103.80.10.10
DomainL_dom-like

LRRC39 PRAMEF25 PRAMEF5 PRAMEF15 LRRK2 SLITRK5 SLITRK3 PRAMEF4 PRAMEF27 PRAMEF6

4.01e-063289010IPR032675
DomainBRCT

PARP4 NBN TP53BP1

9.92e-0519903PF00533
DomainBRCT

PARP4 NBN TP53BP1

1.56e-0422903SM00292
Domain-

PARP4 NBN TP53BP1

1.79e-04239033.40.50.10190
DomainBRCT

PARP4 NBN TP53BP1

2.60e-0426903PS50172
DomainBRCT_dom

PARP4 NBN TP53BP1

3.25e-0428903IPR001357
Domain-

PARP4 INTS6 MDN1 SVEP1

4.48e-04749043.40.50.410
DomainVWFA

PARP4 INTS6 MDN1 SVEP1

6.62e-0482904PS50234
DomainVWA

PARP4 INTS6 MDN1 SVEP1

7.25e-0484904SM00327
DomainLeu-rich_rpt_4

LRRC39 LRRK2

1.01e-0310902IPR025875
DomainLRR_4

LRRC39 LRRK2

1.01e-0310902PF12799
DomainVWF_A

PARP4 INTS6 MDN1 SVEP1

1.34e-0399904IPR002035
DomainVWA

PARP4 INTS6 SVEP1

2.49e-0356903PF00092
DomainPyr_redox_2

MICAL2 ETFDH

3.72e-0319902PF07992
Pubmed

Sertoli cell-only phenotype and scRNA-seq define PRAMEF12 as a factor essential for spermatogenesis in mice.

PRAMEF5 PRAMEF15 PRAMEF4 PRAMEF26 PRAMEF27 PRAMEF6

2.39e-112294631729367
Pubmed

MAGE-B4, a binding partner of PRAMEF12, is dispensable for spermatogenesis and male fertility in mice.

PRAMEF5 PRAMEF15 PRAMEF4 PRAMEF26 PRAMEF27 PRAMEF6

5.63e-112594637451217
Pubmed

Differences in gene expression between mouse and human for dynamically regulated genes in early embryo.

PRAMEF5 PRAMEF15 PRAMEF4 PRAMEF26 PRAMEF27 PRAMEF6

1.19e-102894625089626
Pubmed

Retinoic acid receptors are required for skeletal growth, matrix homeostasis and growth plate function in postnatal mouse.

PRAMEF5 PRAMEF15 PRAMEF4 PRAMEF26 PRAMEF27 PRAMEF6

5.05e-103594619389355
Pubmed

Preferentially Expressed Antigen in Melanoma (PRAME) and the PRAME Family of Leucine-Rich Repeat Proteins.

PRAMEF5 PRAMEF15 PRAMEF4 PRAMEF27 PRAMEF6

1.94e-092094526694250
Pubmed

Differential expression of PRAMEL1, a cancer/testis antigen, during spermatogenesis in the mouse.

PRAMEF5 PRAMEF15 PRAMEF4 PRAMEF6

1.16e-071794423565261
Pubmed

Mouse Pramel1 regulates spermatogonial development by inhibiting retinoic acid signaling during spermatogenesis.

PRAMEF5 PRAMEF15 PRAMEF4 PRAMEF6

1.16e-071794437781892
Pubmed

Pramel15 facilitates zygotic nuclear DNMT1 degradation and DNA demethylation.

PRAMEF5 PRAMEF15 PRAMEF4 PRAMEF6

1.49e-071894439181896
Pubmed

Oocyte-specific gene Oog1 suppresses the expression of spermatogenesis-specific genes in oocytes.

PRAMEF5 PRAMEF15 PRAMEF4 PRAMEF6

1.49e-071894429731491
Pubmed

Identification of a new expanding family of genes characterized by atypical LRR domains. Localization of a cluster preferentially expressed in oocyte.

PRAMEF5 PRAMEF15 PRAMEF4 PRAMEF6

1.49e-071894414675769
Pubmed

The promoter of the oocyte-specific gene, Oog1, functions in both male and female meiotic germ cells in transgenic mice.

PRAMEF5 PRAMEF15 PRAMEF4 PRAMEF6

1.49e-071894423894331
Pubmed

Oogenesin is a novel mouse protein expressed in oocytes and early cleavage-stage embryos.

PRAMEF5 PRAMEF15 PRAMEF4 PRAMEF6

1.49e-071894412890732
Pubmed

Pramel7 mediates ground-state pluripotency through proteasomal-epigenetic combined pathways.

PRAMEF5 PRAMEF15 PRAMEF4 PRAMEF6

1.88e-071994428604677
Pubmed

53BP1 facilitates long-range DNA end-joining during V(D)J recombination.

NBN TP53 TP53BP1

1.90e-07594318931658
Pubmed

Pramel7 mediates LIF/STAT3-dependent self-renewal in embryonic stem cells.

PRAMEF5 PRAMEF15 PRAMEF4 PRAMEF6

2.35e-072094421425410
Pubmed

Oog1, an oocyte-specific protein, interacts with Ras and Ras-signaling proteins during early embryogenesis.

PRAMEF5 PRAMEF15 PRAMEF4 PRAMEF6

2.35e-072094416580637
Pubmed

Cracking the egg: molecular dynamics and evolutionary aspects of the transition from the fully grown oocyte to embryo.

PRAMEF5 PLAA MPP4 GCLM PRAMEF15 PRAMEF4 CPSF2 USF1 PRAMEF6

2.65e-0732694917015433
Pubmed

Oogenesis specific genes (Nobox, Oct4, Bmp15, Gdf9, Oogenesin1 and Oogenesin2) are differentially expressed during natural and gonadotropin-induced mouse follicular development.

PRAMEF5 PRAMEF15 PRAMEF4 PRAMEF6

4.26e-072394419480014
Pubmed

Incomplete reactivation of Oct4-related genes in mouse embryos cloned from somatic nuclei.

PRAMEF5 PRAMEF15 PRAMEF4 PRAMEF6

6.06e-072594412620990
Pubmed

Expression profiling in transgenic FVB/N embryonic stem cells overexpressing STAT3.

PRAMEF5 PRAMEF15 PRAMEF4 PRAMEF6

7.15e-072694418500982
Pubmed

53BP1 promotes ATM activity through direct interactions with the MRN complex.

NBN TP53 TP53BP1

1.06e-06894320010693
Pubmed

Thirteen Ovary-Enriched Genes Are Individually Not Essential for Female Fertility in Mice.

PRAMEF5 PRAMEF15 PRAMEF4 PRAMEF6

1.30e-063094438786026
Pubmed

LSM14B is essential for oocyte meiotic maturation by regulating maternal mRNA storage and clearance.

PRAMEF5 PRAMEF15 PRAMEF4 PRAMEF6

1.70e-063294437889087
Pubmed

Role of genomic instability and p53 in AID-induced c-myc-Igh translocations.

NBN TP53 TP53BP1

3.11e-061194316400328
Pubmed

Identifying chemicals with potential therapy of HIV based on protein-protein and protein-chemical interaction network.

CD4 CTNNB1 TP53

6.81e-061494323762317
Pubmed

Interaction of upstream stimulatory factor proteins with an E-box located within the human CYP1A2 5'-flanking gene contributes to basal transcriptional gene activation.

USF1 USF2

7.23e-06294212663044
Pubmed

Prognostic role of beta-catenin and p53 expression in the metastatic progression of sporadic colorectal cancer.

CTNNB1 TP53

7.23e-06294220129645
Pubmed

Interleukin-34-orchestrated tumor-associated macrophage reprogramming is required for tumor immune escape driven by p53 inactivation.

IL34 TP53

7.23e-06294239321806
Pubmed

CD5 expression correlates with inferior survival and enhances the negative effect of p53 overexpression in diffuse large B-cell lymphoma.

CD5 TP53

7.23e-06294231359442
Pubmed

Cigarette smoking, TP53 Arg72Pro, TP53BP1 Asp353Glu and the risk of lung cancer in a Japanese population.

TP53 TP53BP1

7.23e-06294220372852
Pubmed

Ubiquitous expression of the 43- and 44-kDa forms of transcription factor USF in mammalian cells.

USF1 USF2

7.23e-0629428127680
Pubmed

Transcriptome analysis reveals that p53 and {beta}-catenin alterations occur in a group of aggressive adrenocortical cancers.

CTNNB1 TP53

7.23e-06294220959480
Pubmed

Crystal structure of human 53BP1 BRCT domains bound to p53 tumour suppressor.

TP53 TP53BP1

7.23e-06294212110597
Pubmed

Role of p53 and β-catenin mutations in conjunction with CK19 expression on early tumor recurrence and prognosis of hepatocellular carcinoma.

CTNNB1 TP53

7.23e-06294221061181
Pubmed

Deletion of beta-catenin impairs T cell development.

CD4 CTNNB1

7.23e-06294214608382
Pubmed

Beta-catenin and p53 expression in topographic compartments of colorectal cancer and its prognostic value following surgery.

CTNNB1 TP53

7.23e-06294229146051
Pubmed

Cardiomyocyte-specific deletion of β-catenin protects mouse hearts from ventricular arrhythmias after myocardial infarction.

A1CF CTNNB1

7.23e-06294234489488
Pubmed

Overlapping roles and asymmetrical cross-regulation of the USF proteins in mice.

USF1 USF2

7.23e-0629429520440
Pubmed

Structure, sequence, and chromosomal location of the gene for USF2 transcription factors in mouse.

USF1 USF2

7.23e-0629427774954
Pubmed

Mutations in the Nijmegen breakage syndrome gene in medulloblastomas.

NBN TP53

7.23e-06294218593981
Pubmed

Regulation of basal core promoter activity of human organic cation transporter 1 (OCT1/SLC22A1).

USF1 USF2

7.23e-06294218845576
Pubmed

Regulation of protein quality control by UBE4B and LSD1 through p53-mediated transcription.

TP53 TP53BP1

7.23e-06294225837623
Pubmed

Genetic association between USF 1 and USF 2 gene polymorphisms and Japanese Alzheimer's disease.

USF1 USF2

7.23e-06294216870626
Pubmed

Joint effects of single nucleotide polymorphisms in P53BP1 and p53 on breast cancer risk in a Chinese population.

TP53 TP53BP1

7.23e-06294216314399
Pubmed

[Correlation of 53BP1 and p53 polymorphisms to susceptibility to esophageal squamous cell carcinoma and gastric cardiac adenocarcinoma].

TP53 TP53BP1

7.23e-06294217927872
Pubmed

Upstream stimulatory factors, USF1 and USF2, bind to the human haem oxygenase-1 proximal promoter in vivo and regulate its transcription.

USF1 USF2

7.23e-06294215242350
Pubmed

Separase loss of function cooperates with the loss of p53 in the initiation and progression of T- and B-cell lymphoma, leukemia and aneuploidy in mice.

ESPL1 TP53

7.23e-06294221799785
Pubmed

Beta-catenin expression results in p53-independent DNA damage and oncogene-induced senescence in prelymphomagenic thymocytes in vivo.

CTNNB1 TP53

7.23e-06294218160717
Pubmed

H. pylori-induced promoter hypermethylation downregulates USF1 and USF2 transcription factor gene expression.

USF1 USF2

7.23e-06294220180799
Pubmed

The dual role of helix-loop--helix-zipper protein USF in ribosomal RNA gene transcription in vivo.

USF1 USF2

7.23e-0629429053857
Pubmed

Common genetic variants in 53BP1 associated with nonsmall-cell lung cancer risk in Han Chinese.

TP53 TP53BP1

7.23e-06294224316395
Pubmed

Phosphorylation of p53 by LRRK2 induces microglial tumor necrosis factor α-mediated neurotoxicity.

LRRK2 TP53

7.23e-06294227914807
Pubmed

p202, an interferon-inducible modulator of transcription, inhibits transcriptional activation by the p53 tumor suppressor protein, and a segment from the p53-binding protein 1 that binds to p202 overcomes this inhibition.

TP53 TP53BP1

7.23e-0629428910340
Pubmed

Polymorphic TP53BP1 and TP53 gene interactions associated with risk of squamous cell carcinoma of the head and neck.

TP53 TP53BP1

7.23e-06294217634560
Pubmed

Upstream stimulatory factor proteins are major components of the glucose response complex of the L-type pyruvate kinase gene promoter.

USF1 USF2

7.23e-0629427852331
Pubmed

Sporadic childhood hepatoblastomas show activation of beta-catenin, mismatch repair defects and p53 mutations.

CTNNB1 TP53

7.23e-06294217962810
Pubmed

Structural insight into p53 recognition by the 53BP1 tandem Tudor domain.

TP53 TP53BP1

7.23e-06294220307547
Pubmed

Role for 53BP1 Tudor domain recognition of p53 dimethylated at lysine 382 in DNA damage signaling.

TP53 TP53BP1

7.23e-06294218840612
Pubmed

Evaluation of CTNNB1 and TP53 variability in patients with hepatocellular carcinoma and occult hepatitis B virus infection.

CTNNB1 TP53

7.23e-06294226341700
Pubmed

53BP1 and p53 synergize to suppress genomic instability and lymphomagenesis.

TP53 TP53BP1

7.23e-06294216492765
Pubmed

Reduced membranous beta-catenin protein expression is associated with metastasis and poor prognosis in squamous cell carcinoma of the esophagus.

CTNNB1 TP53

7.23e-06294218455580
Pubmed

53BP1 cooperates with p53 and functions as a haploinsufficient tumor suppressor in mice.

TP53 TP53BP1

7.23e-06294216260621
Pubmed

p53 requires the stress sensor USF1 to direct appropriate cell fate decision.

USF1 TP53

7.23e-06294224831529
Pubmed

Hepatitis B virus-associated hepatocellular carcinoma from India: role of viral genotype and mutations in CTNNB1 (beta-catenin) and TP53 genes.

CTNNB1 TP53

7.23e-06294220963515
Pubmed

Simultaneous Nbs1 and p53 inactivation in neural progenitors triggers high-grade gliomas.

NBN TP53

7.23e-06294237296499
Pubmed

Ser-249 TP53 and CTNNB1 mutations in circulating free DNA of Egyptian patients with hepatocellular carcinoma versus chronic liver diseases.

CTNNB1 TP53

7.23e-06294218313840
Pubmed

Mutational inactivation of the nijmegen breakage syndrome gene (NBS1) in glioblastomas is associated with multiple TP53 mutations.

NBN TP53

7.23e-06294219151620
Pubmed

An essential function for NBS1 in the prevention of ataxia and cerebellar defects.

NBN TP53

7.23e-06294215821748
Pubmed

Immunochemical characterization and transacting properties of upstream stimulatory factor isoforms.

USF1 USF2

7.23e-0629428576131
Pubmed

Differential roles of upstream stimulatory factors 1 and 2 in the transcriptional response of liver genes to glucose.

USF1 USF2

7.23e-0629429685363
Pubmed

Mutations in the p53 tumor suppressor gene and early onset breast cancer.

TP53 TP53BP1

7.23e-06294212170762
Pubmed

Beta-catenin signaling mediates CD4 expression on mature CD8+ T cells.

CD4 CTNNB1

7.23e-06294220631314
Pubmed

Purification, crystallization and preliminary X-ray analysis of the BRCT domains of human 53BP1 bound to the p53 tumour suppressor.

TP53 TP53BP1

7.23e-06294212351827
Pubmed

Negative regulation of CD4 lineage development and responses by CD5.

CD4 CD5

7.23e-06294210586041
Pubmed

53BP1 Goes Back to Its p53 Roots.

TP53 TP53BP1

7.23e-06294227716486
Pubmed

[USF as a key regulatory element of gene expression].

USF1 USF2

7.23e-06294216386222
Pubmed

USF inhibits cell proliferation through delay in G2/M phase in FRTL-5 cells.

USF1 USF2

7.23e-06294217379962
Pubmed

Mbd3, a component of the NuRD co-repressor complex, is required for development of pluripotent cells.

PRAMEF5 PRAMEF15 PRAMEF4 PRAMEF6

7.48e-064694417287250
Pubmed

DUX is a non-essential synchronizer of zygotic genome activation.

PRAMEF5 PRAMEF15 PRAMEF4 PRAMEF6

1.05e-055094431806660
Pubmed

Explorative study to identify novel candidate genes related to oxaliplatin efficacy and toxicity using a DNA repair array.

PARP4 NBN TP53 TP53BP1

1.54e-055594419536092
Pubmed

ZAR1 and ZAR2 are required for oocyte meiotic maturation by regulating the maternal transcriptome and mRNA translational activation.

PRAMEF5 PRAMEF15 PRAMEF4 PRAMEF6

1.90e-055894431598710
Pubmed

An abundance of X-linked genes expressed in spermatogonia.

PRAMEF5 PRAMEF15 PRAMEF4 PRAMEF6

2.03e-055994411279525
Pubmed

Comprehensive analyses of mutations and hepatitis B virus integration in hepatocellular carcinoma with clinicopathological features.

CTNNB1 TP53

2.16e-05394226553052
Pubmed

DNA replication and sister chromatid cohesion 1 promotes breast carcinoma progression by modulating the Wnt/β-catenin signaling and p53 protein.

CTNNB1 TP53

2.16e-05394233184243
Pubmed

Associations of hormone replacement therapy and oral contraceptives with risk of colorectal cancer defined by clinicopathological factors, beta-catenin alterations, expression of cyclin D1, p53, and microsatellite-instability.

CTNNB1 TP53

2.16e-05394224885829
Pubmed

Upregulation of gamma-catenin compensates for the loss of beta-catenin in adult cardiomyocytes.

A1CF CTNNB1

2.16e-05394216936006
Pubmed

Identification and functional analysis of a second RBF-2 binding site within the HIV-1 promoter.

USF1 USF2

2.16e-05394221813151
Pubmed

Comparison of BRCT domains of BRCA1 and 53BP1: a biophysical analysis.

TP53 TP53BP1

2.16e-05394214978302
Pubmed

The 8-kDa dynein light chain binds to p53-binding protein 1 and mediates DNA damage-induced p53 nuclear accumulation.

TP53 TP53BP1

2.16e-05394215611139
Pubmed

Distinct kinetics of DNA repair protein accumulation at DNA lesions and cell cycle-dependent formation of γH2AX- and NBS1-positive repair foci.

NBN TP53BP1

2.16e-05394226482424
Pubmed

Upstream stimulatory factors 1 and 2 mediate the transcription of angiotensin II binding and inhibitory protein.

USF1 USF2

2.16e-05394223653383
Pubmed

Prognostic significance of survivin, β-catenin and p53 expression in urothelial carcinoma.

CTNNB1 TP53

2.16e-05394226614845
Pubmed

Embryonic Stem Cell Differentiation Is Regulated by SET through Interactions with p53 and β-Catenin.

CTNNB1 TP53

2.16e-05394233296674
Pubmed

Molecular basis for the tissue specificity of β-catenin oncogenesis.

CTNNB1 TP53

2.16e-05394222689057
Pubmed

Prognostic values of immune scores and immune microenvironment-related genes for hepatocellular carcinoma.

CTNNB1 TP53

2.16e-05394232213661
Pubmed

Altered expressions of Notch-1 signaling proteins and beta-catenin in progression of carcinoma in situ into squamous carcinoma of uterine cervix.

CTNNB1 TP53

2.16e-05394228195086
Pubmed

p53-induced inhibition of Hif-1 causes cardiac dysfunction during pressure overload.

A1CF TP53

2.16e-05394217334357
Pubmed

Conventional colon adenomas harbor various disturbances in microsatellite stability and contain micro-serrated foci with microsatellite instability.

CTNNB1 TP53

2.16e-05394228234922
Pubmed

ß-Catenin, Cox-2 and p53 immunostaining in colorectal adenomas to predict recurrence after endoscopic polypectomy.

CTNNB1 TP53

2.16e-05394223516071
Pubmed

GPR56 C-terminal fragment mediates signal received by N-terminal fragment of another adhesion GPCR Latrophilin1 in neurons.

ADGRG1 ADGRL1

2.16e-05394236453010
InteractionPRAMEF4 interactions

PRAMEF5 PRAMEF9 PRAMEF4

8.61e-083903int:PRAMEF4
InteractionPRAMEF5 interactions

PRAMEF5 PRAMEF15 PRAMEF4

4.75e-068903int:PRAMEF5
InteractionPRAMEF15 interactions

PRAMEF5 PRAMEF15

1.97e-052902int:PRAMEF15
Cytoband1p36.21

PRAMEF25 PRAMEF5 PRAMEF9 AADACL3 PRAMEF15 PRAMEF4 PRAMEF26 PRAMEF6

8.04e-13639481p36.21
CytobandEnsembl 112 genes in cytogenetic band chr1p36

PRAMEF25 PRAMEF5 PRAMEF9 NMNAT1 AADACL3 PRAMEF15 PRAMEF4 PRAMEF26 PRAMEF27 PRAMEF6

1.43e-066819410chr1p36
GeneFamilyPRAME family

PRAMEF25 PRAMEF5 PRAMEF9 PRAMEF15 PRAMEF4 PRAMEF26 PRAMEF27 PRAMEF6

9.65e-1524638686
CoexpressionKOHOUTEK_CCNT2_TARGETS

PRAMEF5 PRAMEF15 PRAMEF4 PRAMEF26 PRAMEF27 PRAMEF6

4.44e-0781936MM938
CoexpressionGSE9601_UNTREATED_VS_PI3K_INHIBITOR_TREATED_HCMV_INF_MONOCYTE_DN

PHEX PLAA LRRK2 CPSF2 PKHD1L1 TSPAN5 RNF111

1.10e-06150937M6883
CoexpressionINGRAM_SHH_TARGETS_UP

PRAMEF5 PRAMEF15 PRAMEF4 PRAMEF26 PRAMEF27 TSPAN5 PRAMEF6

1.43e-06156937MM550
CoexpressionYAMAZAKI_TCEB3_TARGETS_DN

PRAMEF5 MDN1 GCLM PRAMEF15 PRAMEF4 PRAMEF26 PRAMEF27 PRAMEF6

1.78e-06232938MM1019
CoexpressionKINNEY_DNMT1_METHYLATION_TARGETS

PRAMEF5 PRAMEF15 PRAMEF4 PRAMEF6

6.35e-0634934MM955
CoexpressionDACOSTA_UV_RESPONSE_VIA_ERCC3_COMMON_DN

MDN1 IPO7 BAZ2B ITSN2 NUP98 NBN TSPAN5 DOP1B ZNF292

4.22e-05466939M13522
CoexpressionDACOSTA_UV_RESPONSE_VIA_ERCC3_DN

MDN1 IPO7 BAZ2B MICAL2 ITSN2 NUP98 NBN KLHDC10 TSPAN5 TP53BP1 DOP1B ZNF292

5.02e-058569312M4500
CoexpressionMEISSNER_BRAIN_HCP_WITH_H3_UNMETHYLATED

PRAMEF5 PRAMEF15 PRAMEF4 PRAMEF6

5.08e-0557934MM1262
CoexpressionGSE16386_IL4_VS_IL4_AND_ROSIGLITAZONE_STIM_MACROPHAGE_6H_DN

LRRC39 CFAP52 NMNAT1 NIPSNAP3B ATP2B3 ZNF292

7.61e-05198936M7916
ToppCellfacs-Lung-24m-Endothelial-capillary_endothelial-capillary_endothelial_cell-capillary_type_1_endothelial_cell|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

PRTG A1CF ABCA13 PKHD1L1 ATP2B3 PDE11A

1.24e-06162946bf886e22ff2a20353499004b53f25fb9e6574896
ToppCellTCGA-Bone_and_Soft_Tissue-Primary_Tumor-Sarcoma-Monophasic_Synovial_Sarcoma-5|TCGA-Bone_and_Soft_Tissue / Sample_Type by Project: Shred V9

PRAMEF5 PRAMEF9 PRAMEF15 PRAMEF4 PRAMEF6

1.61e-06939453e05ea0f8f4a7cdb78a596f47d563dc3c94d4d8e
DrugRiboflavine [83-88-5]; Down 200; 10.6uM; HL60; HG-U133A

WSB1 BAZ2B ETFDH NUP98 IL17RC KLHDC10 TP53BP1 ZNF292

1.11e-061969081767_DN
Diseasecolorectal cancer (biomarker_via_orthology)

CTNNB1 TP53

1.19e-046842DOID:9256 (biomarker_via_orthology)
DiseaseAdenoma, Microcystic

CTNNB1 ATP2B3 TP53

1.48e-0436843C0205648
DiseaseAdenoma, Monomorphic

CTNNB1 ATP2B3 TP53

1.48e-0436843C0205649
DiseaseAdenoma, Basal Cell

CTNNB1 ATP2B3 TP53

1.48e-0436843C0205646
DiseaseFollicular adenoma

CTNNB1 ATP2B3 TP53

1.48e-0436843C0205647
DiseasePapillary adenoma

CTNNB1 ATP2B3 TP53

1.48e-0436843C0205650
DiseaseAdenoma, Trabecular

CTNNB1 ATP2B3 TP53

1.48e-0436843C0205651
DiseaseAdenoma

CTNNB1 ATP2B3 TP53

1.48e-0436843C0001430
DiseaseBrain Neoplasms

CYP2C9 CTNNB1 TP53

1.89e-0439843C0006118
DiseaseAcute erythroleukemia - M6a subtype

NUP98 TP53

2.22e-048842C2930975
DiseaseAcute myeloid leukemia FAB-M6

NUP98 TP53

2.22e-048842C2930976
DiseaseAcute erythroleukemia - M6b subtype

NUP98 TP53

2.22e-048842C2930977
DiseaseAcute erythroleukemia

NUP98 TP53

2.22e-048842C2930974
DiseaseHEPATOCELLULAR CARCINOMA

CTNNB1 TP53

2.85e-049842114550
DiseaseAdult Hepatocellular Carcinoma

CTNNB1 TP53

2.85e-049842C0279607
DiseaseHepatocellular carcinoma

CTNNB1 TP53

2.85e-049842cv:C2239176
DiseaseGlioma

CTNNB1 TP53

2.85e-049842cv:C0017638
Diseasestroke outcome severity measurement

A1CF PLAA CPSF2 ZNF292

3.21e-04114844EFO_0009603
DiseaseAdrenal Gland Neoplasms

CTNNB1 TP53

4.33e-0411842C0001624
DiseaseAdrenal Cancer

CTNNB1 TP53

4.33e-0411842C0750887
Diseasegastric adenocarcinoma (is_implicated_in)

ABCA13 TP53

4.33e-0411842DOID:3717 (is_implicated_in)
DiseaseHereditary Breast and Ovarian Cancer Syndrome

NBN TP53

7.13e-0414842C0677776
DiseaseColonic Neoplasms

PARP4 CTNNB1 TP53 TP53BP1

9.48e-04152844C0009375
DiseaseMalignant tumor of colon

PARP4 CTNNB1 TP53 TP53BP1

1.12e-03159844C0007102
DiseaseEndometrioma

RASL11A LRRK2 MED14 ABCC9

1.17e-03161844C0269102
DiseaseEndometriosis

RASL11A LRRK2 MED14 ABCC9

1.17e-03161844C0014175
DiseaseColorectal Neoplasms

ABCA13 RASL11A CTNNB1 TP53 ZNF292

1.19e-03277845C0009404
DiseaseHemangiosarcoma

CTNNB1 TP53

1.19e-0318842C0018923
DiseaseAdrenocortical carcinoma

CTNNB1 TP53

1.19e-0318842C0206686
DiseaseNerve Degeneration

CD4 LRRK2 CTNNB1

1.74e-0383843C0027746
DiseaseGiant Cell Glioblastoma

SRRT TP53 TP53BP1

1.80e-0384843C0334588
DiseaseColorectal cancer

CTNNB1 TP53

2.68e-0327842cv:C0346629
DiseaseCOLORECTAL CANCER

CTNNB1 TP53

2.68e-0327842114500
DiseaseNeoplasm of the large intestine

CTNNB1 TP53

2.68e-0327842cv:C0009404

Protein segments in the cluster

PeptideGeneStartEntry
LFIQWCQDPKNSIIL

CPSF2

341

Q9P2I0
LAPQILEEICQKNNW

A1CF

446

Q9NQ94
NCTSPWVNQVAQKIK

ADGRL1

531

O94910
QVALCIQQLQKSIAW

BAZ2B

1911

Q9UIF8
DPKVQINAICSQWLP

EFL1

336

Q7Z2Z2
CIQKTLNEWSSQINP

GCLM

46

P48507
QPLPIQWKIQNSSCT

CD5

231

P06127
EIEKIWSSPNQLNCE

ABCA13

2986

Q86UQ4
AQKPWLLNATVEENI

ABCC9

756

O60706
QQRKNIPLLTWSFIC

AADACL3

236

Q5VUY0
WGQVIATIPTSQLKC

ATP2B3

1051

Q16720
LLPNWKVNVDVDSNI

CLDN20

26

P56880
QVVENLKAQALCSWT

ITSN2

896

Q9NZM3
VTEPSSKNLWEQICK

IQCK

46

Q8N0W5
QFILERKSPQTCWQV

INTS6

336

Q9UL03
NCKQWEFQPLTATRS

KCTD19

646

Q17RG1
EKWLLNLIQNECSVP

NXF3

126

Q9H4D5
TDPSQRLVQNCLWTL

CTNNB1

371

P35222
PVWQLSEKKQINVCS

NUP98

1406

P52948
LAKQVWTPQDRQCVL

MDN1

31

Q9NU22
WTVTPFVVQICKNLD

DOP1B

1536

Q9Y3R5
TLWLQRNEITCLPQT

LRRC39

226

Q96DD0
NRKIWPTECQTGQLK

CFAP52

191

Q8N1V2
SLTCQQVSPQMWQLL

IPO7

661

O95373
TREWTQLKPNNLSCD

KLHDC10

241

Q6PID8
SVLCVPIWNSNHQII

PDE11A

511

Q9HCR9
VNNLLEKISQTAPEW

COPS4

381

Q9BT78
CKEWQEQSIIPNLAR

NIPSNAP3B

106

Q9BS92
LLSAIQKAQEEPQWV

MPP4

611

Q96JB8
KRQACPNWVFQTLVI

MYRFL

616

Q96LU7
EVEVNCKWVLPILTQ

PRAMEF15

211

P0DUQ1
CIRQNTSEKQNPWTE

KIF24

206

Q5T7B8
QKEIQSCLTVWDINL

LRRK2

2486

Q5S007
QLAKTCPVQLWVDST

TP53

136

P04637
CHSVSVKWQQLNPDV

PARP4

1051

Q9UKK3
QLKWNVQFCLTIPPS

MED14

1331

O60244
VCSPTAVNTQRKLWQ

MTERF2

106

Q49AM1
LEPLNCTTISVRWQQ

PRTG

626

Q2VWP7
TCDIKDPSQNINWVV

ETFDH

591

Q16134
NLVQKWQVLSEVLSC

ESPL1

976

Q14674
KQSSVLNWQDCEVPS

IL34

181

Q6ZMJ4
SSPAWTQCQQLSQKL

IL23A

26

Q9NPF7
QPKEVQTLWCTDSQV

C1orf112

356

Q9NSG2
QLQKNLTCEVWGPTS

CD4

321

P01730
QLQPKNVTLQCVFWV

ADGRG1

336

Q9Y653
KTCINPLQVWITSAS

MDH1B

126

Q5I0G3
TTINCFIFIPQLKQW

GPR156

301

Q8NFN8
NVTTNCWKQLTHLPK

KLHDC1

281

Q8N7A1
SWLVEQCRQLGLKQP

DDX49

11

Q9Y6V7
KILSSPWIQICNNFS

CYP2C9

206

P11712
VEVNCKWVLPILTQF

PRAMEF26

116

H0Y7S4
TRLQWDIPKQCQAVI

CPT1B

516

Q92523
STNQTPALNLLWEKC

FOCAD

41

Q5VW36
QVNSSEKLQLQECLW

IL17RC

441

Q8NAC3
DIRPSKLLTWCQQQT

MICAL2

516

O94851
NQSFCPTVNLDKLWT

RPL27A

66

P46776
SLPQVVDSLSKCVQW

RASL11A

91

Q6T310
ILEEKRWPQLCSTQS

NHSL2

231

Q5HYW2
TNSQTLIPDCQKKWI

NBN

276

O60934
NLWKNIVVLCVNSLT

SLC22A23

426

A1A5C7
CVQLKNNPLSWTIIA

OVCH1

616

Q7RTY7
ENPWNCTCEIVQLKS

SLITRK3

231

O94933
EVEVNCKWVLPILTQ

PRAMEF25

211

A6NGN4
LTRPVVLWSQQDVCK

SAMD10

111

Q9BYL1
EVEVNCKWVLPILTQ

PRAMEF27

211

A3QJZ7
SQQWNDSFPVCKIVL

SVEP1

2366

Q4LDE5
NPDATIWTAKQQVLC

SHANK1

91

Q9Y566
RSVNIKEICWNLQNI

SRRT

471

Q9BXP5
EVEVNCKWVLPILTQ

PRAMEF4

211

O60810
EVNCKWVLPILTQFT

PRAMEF6

211

Q5VXH4
WQTAVTKCIPQQKND

SENP5

696

Q96HI0
WQVKLRNLIEPEQCT

USP19

346

O94966
QVCVDQWLITNKKCP

RNF111

966

Q6ZNA4
KVVELQLEENPWNCS

SLITRK5

226

O94991
VINTTQDPCSWVDKL

TMEM144

166

Q7Z5S9
EVEVNCKWVLPILTQ

PRAMEF9

211

P0DUQ2
PTVQQLQILWKAINC

PLAA

591

Q9Y263
EVNCKWVLPILTQFT

PRAMEF5

211

Q5TYX0
QETGVWKNPVLCTIL

ZNF292

156

O60281
TTTLLPQWDKCVNFI

PHEX

396

P78562
ALQLPVVSQEWVIQC

TP53BP1

1936

Q12888
NLLVCPKTTIWNAQQ

PKHD1L1

3871

Q86WI1
PKTTIWNAQQKHCEL

PKHD1L1

3876

Q86WI1
LTNQWAVTNPKDVLV

SYNGR2

126

O43760
QQDACLILVKGNWTT

nan

21

Q96IR3
INNWIVQLSKIIPDC

USF2

251

Q15853
CQQWLQPETHTKEQI

ZSCAN26

76

Q16670
CVPQFEKWLQDNLTI

TSPAN5

221

P62079
CNTPVKSELLWQTHV

ZNF830

56

Q96NB3
SQSIAIHEPQCLQKW

ZNF474

106

Q6S9Z5
RTVKLVPWSQCLQNF

WSB1

56

Q9Y6I7
KLIQPHVQASNNCWE

VEZT

476

Q9HBM0
IPNNVKLQCVSWNKE

WDR35

11

Q9P2L0
SQCQEWLILSTQVPG

ZNF214

101

Q9UL59
NNWIVQLSKIIPDCS

USF1

216

P22415
TQKLETVWLSGICQN

GRIN2C

786

Q14957
PNLWKSEDITQIVAN

NMNAT1

166

Q9HAN9