Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	cellular response to estradiol stimulus	NRIP1 HSF1 ESR2	3.06e-05	37	34	3	GO:0071392
Domain	CH	MACF1 SPECC1	5.53e-03	65	32	2	SM00033
Domain	CH	MACF1 SPECC1	6.39e-03	70	32	2	PF00307
Domain	-	MACF1 SPECC1	6.57e-03	71	32	2	1.10.418.10
Domain	CH	MACF1 SPECC1	6.93e-03	73	32	2	PS50021
Domain	DEAD	ASCC3 TDRD12	6.93e-03	73	32	2	PF00270
Domain	DEAD/DEAH_box_helicase_dom	ASCC3 TDRD12	6.93e-03	73	32	2	IPR011545
Domain	CH-domain	MACF1 SPECC1	7.30e-03	75	32	2	IPR001715
Domain	WHTH_DNA-bd_dom	ASCC3 HSF1 E2F8	8.08e-03	242	32	3	IPR011991
Pubmed	Negative regulation of estrogen signaling by ERβ and RIP140 in ovarian cancer cells.	NRIP1 ESR2	9.84e-07	2	35	2	23885094
Pubmed	Prognostic relevance of RIP140 and ERβ expression in unifocal versus multifocal breast cancers: a preliminary report.	NRIP1 ESR2	9.84e-07	2	35	2	30669416
Pubmed	Receptor-interacting protein 140 as a co-repressor of Heat Shock Factor 1 regulates neuronal stress response.	NRIP1 HSF1	9.84e-07	2	35	2	29233969
Pubmed	New insights into the genetic basis of premature ovarian insufficiency: Novel causative variants and candidate genes revealed by genomic sequencing.	MACF1 NRIP1	2.95e-06	3	35	2	33036707
Pubmed	A multigenic combination of estrogen related genes are associated with the duration of fertility period in the Spanish population.	NRIP1 ESR2	2.95e-06	3	35	2	23173577
Pubmed	Integrative genomics of gene and metabolic regulation by estrogen receptors α and β, and their coregulators.	NRIP1 ESR2	5.90e-06	4	35	2	23774759
Pubmed	An Interaction Landscape of Ubiquitin Signaling.	MACF1 APLP2 ASCC3 TRIP12 GLG1 UBXN7	7.84e-06	481	35	6	28190767
Pubmed	Multilocus analyses of estrogen-related genes reveal involvement of the ESR1 gene in male infertility and the polygenic nature of the pathology.	NRIP1 ESR2	9.82e-06	5	35	2	16213843
Pubmed	Multilocus analyses reveal involvement of the ESR1, ESR2, and FSHR genes in migraine.	NRIP1 ESR2	9.82e-06	5	35	2	19093296
Pubmed	Changes in vitamin D target gene expression in adipose tissue monitor the vitamin D response of human individuals.	NRIP1 TRAK1	9.82e-06	5	35	2	24975273
Pubmed	Multigenic combination of estrogen-related genes is associated with age at natural menopause in a Spanish population.	NRIP1 ESR2	1.47e-05	6	35	2	19933466
Pubmed	Contribution of polymorphisms in ESR1, ESR2, FSHR, CYP19A1, SHBG, and NRIP1 genes to migraine susceptibility in Turkish population.	NRIP1 ESR2	1.47e-05	6	35	2	27019440
Pubmed	Fine mapping of the friend retrovirus resistance gene, Rfv3, on mouse chromosome 15.	HSF1 APOBEC3B	2.74e-05	8	35	2	10438878
Pubmed	ATG5 is required for B cell polarization and presentation of particulate antigens.	ASCC3 SPECC1 TRIP12 GLG1 CSTF2T LRRFIP2	6.47e-05	701	35	6	30196744
Pubmed	Regulation of glucocorticoid receptor activity by 14--3-3-dependent intracellular relocalization of the corepressor RIP140.	NRIP1 ESR2	7.62e-05	13	35	2	11266503
Pubmed	Multiplexed molecular interactions of nuclear receptors using fluorescent microspheres.	NRIP1 ESR2	8.89e-05	14	35	2	11500849
Pubmed	The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.	MACF1 EXOC5 ASCC3 MED23 TRIP12 LRRFIP2	1.00e-04	759	35	6	35915203
Pubmed	The deubiquitylase USP33 discriminates between RALB functions in autophagy and innate immune response.	EXOC5 PIH1D2	1.02e-04	15	35	2	24056301
Pubmed	Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	MACF1 UBXN7 XPO7	1.45e-04	101	35	3	9872452
Pubmed	Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	MACF1 MED23 ZNF644	1.54e-04	103	35	3	10574462
Pubmed	NuRD subunit CHD4 regulates super-enhancer accessibility in rhabdomyosarcoma and represents a general tumor dependency.	TRIP12 ZNF644 CHD5	1.54e-04	103	35	3	32744500
Pubmed	The TRAP/Mediator coactivator complex interacts directly with estrogen receptors alpha and beta through the TRAP220 subunit and directly enhances estrogen receptor function in vitro.	MED23 ESR2	2.24e-04	22	35	2	11867769
Pubmed	A large set of estrogen receptor β-interacting proteins identified by tandem affinity purification in hormone-responsive human breast cancer cell nuclei.	NRIP1 ESR2	2.91e-04	25	35	2	21182203
Pubmed	Functional proteomics mapping of a human signaling pathway.	MACF1 APLP2 ASCC3 TRIP12 TRAK1	2.97e-04	591	35	5	15231748
Pubmed	Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.	MACF1 MED23 TRIP12	3.06e-04	130	35	3	12421765
Pubmed	Automated yeast two-hybrid screening for nuclear receptor-interacting proteins.	MACF1 NRIP1 ESR2	3.27e-04	133	35	3	15604093
Pubmed	K48- and K63-linked ubiquitin chain interactome reveals branch- and length-specific ubiquitin interactors.	APLP2 ASCC3 HSF1 GLG1 UBXN7	3.28e-04	604	35	5	38803224
Pubmed	Interactions of the Antiviral Factor Interferon Gamma-Inducible Protein 16 (IFI16) Mediate Immune Signaling and Herpes Simplex Virus-1 Immunosuppression.	ASCC3 TRIP12 APOBEC3B LRRFIP2	3.38e-04	332	35	4	25693804
Pubmed	Tagging genes with cassette-exchange sites.	MACF1 MED23 TRIP12 HSPBAP1	3.50e-04	335	35	4	15741177
Pubmed	Increased gene copy number of VAMP7 disrupts human male urogenital development through altered estrogen action.	NRIP1 ESR2	3.66e-04	28	35	2	24880616
Pubmed	Disrupted in Schizophrenia 1 Interactome: evidence for the close connectivity of risk genes and a potential synaptic basis for schizophrenia.	MACF1 CCDC136 TRAK1	4.74e-04	151	35	3	17043677
Pubmed	TRIP12 promotes small-molecule-induced degradation through K29/K48-branched ubiquitin chains.	MED23 TRIP12	5.09e-04	33	35	2	33567268
Pubmed	A cryptic Tudor domain links BRWD2/PHIP to COMPASS-mediated histone H3K4 methylation.	CHD5 UBXN7	6.07e-04	36	35	2	29089422
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	MACF1 APLP2 ASCC3 MED23 SPECC1 GLG1 CSTF2T	6.29e-04	1497	35	7	31527615
Pubmed	MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	MACF1 APLP2 MED23 CBFA2T3 TRIP12 CSTF2T	6.70e-04	1082	35	6	38697112
Pubmed	Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism.	NRIP1 CCDC136 ESR2 PIH1D2	6.94e-04	402	35	4	24722188
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	MACF1 ZNF644 TRAK1 XPO7	7.26e-04	407	35	4	12693553
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	NRIP1 ASCC3 CSTF2T ZNF644	8.02e-04	418	35	4	34709266
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	STK10 HSF1 TRIP12 CSTF2T ZNF644	1.01e-03	774	35	5	15302935
Interaction	KAT5 interactions	CCDC125 APLP2 MED23 HSF1 CCDC136 ESR2 LRRFIP2	1.87e-06	358	34	7	int:KAT5
Interaction	HGS interactions	UBQLNL APLP2 EXOC5 CCDC136 CSTF2T ESR2 TRAK1	2.23e-05	523	34	7	int:HGS
Cytoband	1p22.2	LRRC8D ZNF644	2.11e-04	28	35	2	1p22.2
Cytoband	Ensembl 112 genes in cytogenetic band chr1p22	LRRC8D ZNF644	4.93e-03	137	35	2	chr1p22
Cytoband	Ensembl 112 genes in cytogenetic band chr3p22	LRRFIP2 TRAK1	8.71e-03	184	35	2	chr3p22
Cytoband	Ensembl 112 genes in cytogenetic band chr11p15	OR51G2 UBQLNL E2F8	9.02e-03	564	35	3	chr11p15
Cytoband	11p15.4	OR51G2 UBQLNL	1.02e-02	200	35	2	11p15.4
Coexpression	GSE19888_ADENOSINE_A3R_INH_PRETREAT_AND_ACT_BY_A3R_VS_A3R_INH_AND_TCELL_MEMBRANES_ACT_MAST_CELL_UP	NRIP1 APLP2 HSPBAP1 ZNF644 UBXN7	4.93e-06	194	34	5	M7313
Coexpression	STEARMAN_LUNG_CANCER_EARLY_VS_LATE_UP	NRIP1 APLP2 MED23 GLG1	2.25e-05	128	34	4	M4925
Coexpression	STEARMAN_LUNG_CANCER_EARLY_VS_LATE_UP	NRIP1 APLP2 MED23 GLG1	2.69e-05	134	34	4	MM748
Coexpression	GSE3920_IFNA_VS_IFNB_TREATED_ENDOTHELIAL_CELL_UP	MACF1 ASCC3 HSPBAP1 CCDC63	6.65e-05	169	34	4	M6700
Coexpression	DACOSTA_UV_RESPONSE_VIA_ERCC3_DN	STK10 MACF1 NRIP1 ASCC3 TRIP12 TRAK1 UBXN7	9.62e-05	856	34	7	M4500
Coexpression	GSE1791_CTRL_VS_NEUROMEDINU_IN_T_CELL_LINE_6H_UP	NRIP1 TRIP12 LRRC8D HSPBAP1	1.23e-04	198	34	4	M6166
Coexpression	GSE21063_CTRL_VS_ANTI_IGM_STIM_BCELL_NFATC1_KO_16H_DN	STK10 MED23 HSF1 CCDC63	1.25e-04	199	34	4	M8259
Coexpression	GSE13484_12H_UNSTIM_VS_YF17D_VACCINE_STIM_PBMC_UP	MACF1 LRRC8D GLG1 XPO7	1.28e-04	200	34	4	M3271
ToppCell	PND10-Endothelial-Endothelial_blood-vessel-Macrovascular_EC\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	APLP2 MYZAP CBFA2T3 SPECC1 ESR2	3.83e-07	191	35	5	b270c3dd5952f56b9bdceabe13e298fe6757563b
ToppCell	wk_15-18-Hematologic-Myeloid-HSC\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	CCDC125 NRIP1 CBFA2T3 CCDC63	8.76e-06	167	35	4	5f793eafbb593317caa9afd8267e561e09058ddb
ToppCell	PND10-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC-VEC_mature\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	APLP2 MYZAP CBFA2T3 SPECC1	1.46e-05	190	35	4	9b0ad888eb20acc011904d8593bc32bdef18d050
ToppCell	PND10-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	APLP2 MYZAP CBFA2T3 SPECC1	1.52e-05	192	35	4	c157981b9a179925edcaabc0cb3b8805f0929004
ToppCell	LPS_IL1RA-Hematopoietic_Erythro-Megakary-Erythro-Mega-Erythroid\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	SPECC1 E2F8 DNAI2 XPO7	1.78e-05	200	35	4	fa1eaf008b54bdf7bbcdec8134460c5f64490de9
Disease	arginine measurement	MED23 DNAI2	3.02e-04	23	33	2	EFO_0020990
Disease	osteoporosis (is_implicated_in)	NRIP1 ESR2	5.53e-04	31	33	2	DOID:11476 (is_implicated_in)
Disease	calcium measurement	RAB38 MACF1 ASCC3 MYZAP ESR2	6.23e-04	628	33	5	EFO_0004838
Disease	atrial fibrillation	MYZAP CCDC136 ESR2 XPO7	7.54e-04	371	33	4	EFO_0000275
Disease	Malignant neoplasm of breast	MACF1 NRIP1 APOBEC3B ZNF644 ESR2 CHD5	1.09e-03	1074	33	6	C0006142
Disease	Intellectual Disability	MACF1 ASCC3 MED23 RTTN	1.50e-03	447	33	4	C3714756
Disease	mean reticulocyte volume	CBFA2T3 SPECC1 E2F8 RTTN XPO7	1.82e-03	799	33	5	EFO_0010701
Disease	Endometrial Neoplasms	NRIP1 ESR2	1.93e-03	58	33	2	C0014170
Disease	transient cerebral ischemia (implicated_via_orthology)	HSF1 ESR2	2.34e-03	64	33	2	DOID:224 (implicated_via_orthology)
Disease	Benign Neoplasm	HSF1 APOBEC3B	2.64e-03	68	33	2	C0086692
Disease	Neoplasms	HSF1 APOBEC3B	2.64e-03	68	33	2	C0027651
Disease	Endometrial Carcinoma	NRIP1 ESR2	2.95e-03	72	33	2	C0476089
Disease	alcohol drinking	EXOC5 CCDC63	3.72e-03	81	33	2	EFO_0004329
Disease	mean corpuscular hemoglobin concentration	MACF1 SPECC1 E2F8 RTTN XPO7	7.24e-03	1105	33	5	EFO_0004528
Disease	Colorectal Carcinoma	RAB38 CBFA2T3 ESR2 CHD5	7.52e-03	702	33	4	C0009402
Disease	sleep duration, high density lipoprotein cholesterol measurement	MACF1 MYZAP	8.10e-03	121	33	2	EFO_0004612, EFO_0005271

Protein segments in the cluster

Peptide	Gene	Start	Entry
SLLNIMMDLKKCCNH	CHD5	981	Q8TDI0
MDQHMGFLCNEAKNL	APOBEC3B	231	Q9UH17
ERHNNNMMAKTLEEC	SPECC1	526	Q5M775
MQLGSIMEHCIKQNN	DNAI2	111	Q9GZS0
LMNNGLKMDQFCKEH	RAB38	136	P57729
QIAMFCGKLNMHVNI	APLP2	51	Q06481
KGMEHLLNMKCKNVV	ESR2	471	Q92731
QECMDSKLLAMKHEN	HSF1	151	Q00613
HQEVMKLACADMKAN	OR51G2	186	Q8NGK0
DMVCNMLGLNKQHKQ	MED23	281	Q9ULK4
NNEMALLESKNLCMV	NRIP1	841	P48552
WKHLNNLLNCIMDMV	CBFA2T3	396	O75081
QKHMCSVLQHKMEEL	LRRFIP2	431	Q9Y608
DKQCEMMKARHQELL	MACF1	3806	Q9UPN3
GEHMKKEELNVCNHM	HSPBAP1	351	Q96EW2
DLMECLIQNKHQKDM	GLG1	716	Q92896
NCMIGQMKHILAAEQ	EXOC5	541	O00471
LDIKQQKMAQENMCC	CCDC125	246	Q86Z20
YQQLQHCLLMEKKTM	CCDC63	196	Q8NA47
KMAQLAAICKMQLEE	E2F8	436	A0AVK6
FELMKQMKLCVQNSH	CSTF2T	141	Q9H0L4
LKKMMNVAELELQNC	LRRC8D	631	Q7L1W4
LKANLIDNCMEQMKH	RTTN	1881	Q86VV8
IDNCMEQMKHINAQL	RTTN	1886	Q86VV8
FCLKMHKEMIFNLQN	TDRD12	701	Q587J7
AEEQMHGMKNKCQEL	CCDC136	306	Q96JN2
LGIKCANKMQQLNNM	ASCC3	686	Q8N3C0
CMEMLHEAQEELKNL	TRAK1	336	Q9UPV9
NQLIQMAMKCIEEKF	PIH1D2	126	Q8WWB5
KHENQMRDMLAQCES	STK10	861	O94804
KEMLLAHFQCQMDQL	UBQLNL	56	Q8IYU4
QKMDLTMHSALDCKQ	ZNF644	1221	Q9H582
KQQAMHLCFENLMEG	XPO7	1031	Q9UIA9
GKHMLEACNNNLEMA	UBXN7	31	O94888
LALVHKMNNCLSQME	TRIP12	1216	Q14669
LDDMVHCQQKKVKQM	MYZAP	356	P0CAP1