Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionkinase regulator activity

TAOK2 MOB3C RICTOR GCKR MOB3A CCNA2

3.31e-04305616GO:0019207
GeneOntologyMolecularFunctiontransferase activity, transferring phosphorus-containing groups

TAOK2 MST1 PARP1 CAMKK1 TRIO TUT7 INSRR DGKH MST1L ADPGK

5.08e-049386110GO:0016772
GeneOntologyMolecularFunctionkinase binding

TAOK2 MST1 PARP1 TIAM1 UNC5C RICTOR DGKH GCKR MST1L CCNA2

6.55e-049696110GO:0019900
GeneOntologyMolecularFunctionprotein kinase activator activity

TAOK2 MOB3C RICTOR MOB3A

1.12e-03149614GO:0030295
GeneOntologyMolecularFunctionprotein kinase regulator activity

TAOK2 MOB3C RICTOR MOB3A CCNA2

1.16e-03259615GO:0019887
GeneOntologyMolecularFunctionphosphotransferase activity, alcohol group as acceptor

TAOK2 MST1 CAMKK1 TRIO INSRR DGKH MST1L ADPGK

1.36e-03709618GO:0016773
GeneOntologyMolecularFunctionkinase activator activity

TAOK2 MOB3C RICTOR MOB3A

1.42e-03159614GO:0019209
GeneOntologyMolecularFunctionkinase activity

TAOK2 MST1 CAMKK1 TRIO INSRR DGKH MST1L ADPGK

2.17e-03764618GO:0016301
GeneOntologyMolecularFunctionreceptor tyrosine kinase binding

MST1 TIAM1 MST1L

2.64e-0390613GO:0030971
GeneOntologyCellularComponentexocytic vesicle

PHAF1 SYT3 RAB40AL RAB40C RAB40B RAB40A

3.36e-04320616GO:0070382
GeneOntologyCellularComponentlipid droplet

RAB40AL RAB40C RAB40B RAB40A

3.68e-04116614GO:0005811
GeneOntologyCellularComponentouter dynein arm

DNAI2 DNAH5

5.43e-0412612GO:0036157
MousePhenoincreased capillary density

MB PLXND1

1.11e-052472MP:0020330
DomainSOCS

RAB40AL RAB40C WSB2 RAB40B RAB40A

5.10e-0920625SM00253
DomainSOCS_box

RAB40AL RAB40C WSB2 RAB40B RAB40A

1.58e-0738625PF07525
DomainSOCS_box

RAB40AL RAB40C WSB2 RAB40B RAB40A

1.81e-0739625SM00969
DomainSOCS

RAB40AL RAB40C WSB2 RAB40B RAB40A

1.81e-0739625PS50225
DomainSOCS_box

RAB40AL RAB40C WSB2 RAB40B RAB40A

1.81e-0739625IPR001496
DomainRAB

RAB40AL RAB40C RAB40B RAB40A

1.01e-0473624PS51419
DomainPAN_AP

MST1 MST1L

1.08e-045622SM00473
Domain-

TDRD6 RNF17

1.61e-0466222.40.50.90
DomainStaphylococal_nuclease_OB-fold

TDRD6 RNF17

1.61e-046622IPR016071
DomainPAN

MST1 MST1L

2.25e-047622PS50948
DomainPan_app

MST1 MST1L

2.25e-047622IPR003609
DomainMob1_phocein

MOB3C MOB3A

2.25e-047622PF03637
DomainPAN_1

MST1 MST1L

2.25e-047622PF00024
DomainMOB_kinase_act_fam

MOB3C MOB3A

2.25e-047622IPR005301
Domain-

MOB3C MOB3A

2.25e-0476221.20.140.30
DomainMob1_phocein

MOB3C MOB3A

2.25e-047622SM01388
DomainQuinoprotein_ADH-like_supfam

WDR88 AHCTF1 EML3

7.25e-0453623IPR011047
DomainTUDOR

TDRD6 RNF17

9.62e-0414622PF00567
DomainFerritin-like_SF

MOB3C MOB3A

9.62e-0414622IPR009078
DomainRas

RAB40AL RAB40C RAB40B RAB40A

1.08e-03136624PF00071
DomainDH_1

ARHGEF40 TIAM1 TRIO

1.20e-0363623PS00741
DomainKringle

MST1 MST1L

1.43e-0317622IPR000001
DomainKringle_CS

MST1 MST1L

1.43e-0317622IPR018056
DomainKRINGLE_2

MST1 MST1L

1.43e-0317622PS50070
DomainKringle

MST1 MST1L

1.43e-0317622PF00051
DomainKRINGLE_1

MST1 MST1L

1.43e-0317622PS00021
DomainKR

MST1 MST1L

1.43e-0317622SM00130
Domain-

TRIO TAPBPL UNC5C MPZL1 INSRR PLXND1 HCFC2 CNTN2

1.51e-036636282.60.40.10
DomainRhoGEF

ARHGEF40 TIAM1 TRIO

1.63e-0370623PF00621
DomainDH_2

ARHGEF40 TIAM1 TRIO

1.63e-0370623PS50010
DomainDH-domain

ARHGEF40 TIAM1 TRIO

1.70e-0371623IPR000219
Domain-

ARHGEF40 TIAM1 TRIO

1.70e-03716231.20.900.10
DomainSmall_GTPase

RAB40AL RAB40C RAB40B RAB40A

1.97e-03160624IPR001806
DomainIg-like_fold

TRIO TAPBPL UNC5C MPZL1 INSRR PLXND1 HCFC2 CNTN2

2.23e-03706628IPR013783
DomainPH

ARHGEF40 TIAM1 TRIO DGKH PLEKHA7

2.28e-03278625SM00233
DomainSmall_GTP-bd_dom

RAB40AL RAB40C RAB40B RAB40A

2.30e-03167624IPR005225
DomainPH_DOMAIN

ARHGEF40 TIAM1 TRIO DGKH PLEKHA7

2.32e-03279625PS50003
DomainPH_domain

ARHGEF40 TIAM1 TRIO DGKH PLEKHA7

2.35e-03280625IPR001849
DomainTUDOR

TDRD6 RNF17

2.62e-0323622PS50304
DomainTUDOR

TDRD6 RNF17

3.61e-0327622SM00333
DomainTudor

TDRD6 RNF17

4.44e-0330622IPR002999
Domain-

WDR88 DNAI2 WSB2 PLXND1 EML3

4.93e-033336252.130.10.10
DomainKringle-like

MST1 MST1L

5.04e-0332622IPR013806
DomainWD40/YVTN_repeat-like_dom

WDR88 DNAI2 WSB2 PLXND1 EML3

5.06e-03335625IPR015943
Pubmed

The SOCS box: a tale of destruction and degradation.

RAB40AL RAB40C WSB2 RAB40B RAB40A

1.09e-084162512076535
Pubmed

mTORC2 regulates cardiac response to stress by inhibiting MST1.

MST1 RICTOR MST1L

2.16e-08462325843706
Pubmed

Rab40C is a novel Varp-binding protein that promotes proteasomal degradation of Varp in melanocytes.

RAB40C RAB40B RAB40A

2.16e-08462325661869
Pubmed

Rab40b and Tks5 interact at invadopodia during metastasis.

RAB40AL RAB40B RAB40A

5.38e-08562327909076
Pubmed

LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy.

ARHGEF40 TIAM1 TRIO AHNAK TUT7 RICTOR ADPGK

7.54e-0820262733005030
Pubmed

Evolution of the Rab family of small GTP-binding proteins.

RAB40C RAB40B RAB40A

3.00e-07862311697911
Pubmed

Mst1 regulates post-infarction cardiac injury through the JNK-Drp1-mitochondrial fission pathway.

MST1 MST1L

3.13e-06262229760744
Pubmed

Regulation of lipid homeostasis by the TBC protein dTBC1D22 via modulation of the small GTPase Rab40 to facilitate lipophagy.

RAB40C RAB40A

3.13e-06262234469730
Pubmed

Cloning, sequencing, and expression of human macrophage stimulating protein (MSP, MST1) confirms MSP as a member of the family of kringle proteins and locates the MSP gene on chromosome 3.

MST1 MST1L

3.13e-0626228393443
Pubmed

MSP is a negative regulator of inflammation and lipogenesis in ex vivo models of non-alcoholic steatohepatitis.

MST1 MST1L

3.13e-06262227609031
Pubmed

Hepatocyte growth factor-like protein is required for prostate tumor growth in the TRAMP mouse model.

MST1 MST1L

3.13e-06262224980820
Pubmed

Mst1 deletion reduces hyperglycemia-mediated vascular dysfunction via attenuating mitochondrial fission and modulating the JNK signaling pathway.

MST1 MST1L

3.13e-06262231206688
Pubmed

Structure of the human D1F15S1A locus: a chromosome 1 locus with 97% identity to the chromosome 3 gene coding for hepatocyte growth factor-like protein.

MST1 MST1L

3.13e-06262210728827
Pubmed

Genetically selected Marchigian Sardinian alcohol-preferring (msP) rats: an animal model to study the neurobiology of alcoholism.

MST1 MST1L

3.13e-06262216961763
Pubmed

Inhibiting endothelial cell Mst1 attenuates acute lung injury in mice.

MST1 MST1L

3.13e-06262239253972
Pubmed

Proprotein convertase subtilisin/kexin Type 9 is required for Ahnak-mediated metastasis of melanoma into lung epithelial cells.

AHNAK PCSK9

3.13e-06262234352405
Pubmed

Cerebral ischemia-reperfusion is modulated by macrophage-stimulating 1 through the MAPK-ERK signaling pathway.

MST1 MST1L

3.13e-06262232017081
Pubmed

Mst1 inhibition attenuates non-alcoholic fatty liver disease via reversing Parkin-related mitophagy.

MST1 MST1L

3.13e-06262230708325
Pubmed

Functional consequences of the macrophage stimulating protein 689C inflammatory bowel disease risk allele.

MST1 MST1L

3.13e-06262224409221
Pubmed

Melatonin alleviates postinfarction cardiac remodeling and dysfunction by inhibiting Mst1.

MST1 MST1L

3.13e-06262227696525
Pubmed

Hepatocyte-specific expression of the mouse hepatocyte growth factor-like protein.

MST1 MST1L

3.13e-0626228340069
Pubmed

Biological effects of targeted inactivation of hepatocyte growth factor-like protein in mice.

MST1 MST1L

3.13e-0626229486989
Pubmed

Treatment with XMU-MP-1 erases hyperglycaemic memory in hearts of diabetic mice.

MST1 MST1L

3.13e-06262233887258
Pubmed

HGFL supports mammary tumorigenesis by enhancing tumor cell intrinsic survival and influencing macrophage and T-cell responses.

MST1 MST1L

3.13e-06262225938541
Pubmed

Slac2-a/melanophilin, the missing link between Rab27 and myosin Va: implications of a tripartite protein complex for melanosome transport.

RAB40AL RAB40C RAB40B RAB40A

3.61e-065862411856727
Pubmed

Distinct Rab binding specificity of Rim1, Rim2, rabphilin, and Noc2. Identification of a critical determinant of Rab3A/Rab27A recognition by Rim2.

RAB40AL RAB40C RAB40B RAB40A

4.43e-066162412578829
Pubmed

The Slp homology domain of synaptotagmin-like proteins 1-4 and Slac2 functions as a novel Rab27A binding domain.

RAB40AL RAB40C RAB40B RAB40A

4.73e-066262411773082
Pubmed

Screening for target Rabs of TBC (Tre-2/Bub2/Cdc16) domain-containing proteins based on their Rab-binding activity.

RAB40AL RAB40C RAB40B RAB40A

8.60e-067262416923123
Pubmed

Pericentrosomal targeting of Rab6 secretory vesicles by Bicaudal-D-related protein 1 (BICDR-1) regulates neuritogenesis.

RAB40C RAB40B RAB40A

9.31e-062362320360680
Pubmed

Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.

WIZ AHNAK UNC5C MPZL1 TNRC6B RICTOR PLXND1 HCFC2 PCDH9

9.32e-0677762935844135
Pubmed

The Ron/STK receptor tyrosine kinase is essential for peri-implantation development in the mouse.

MST1 MST1L

9.37e-06362210225971
Pubmed

Inhibition of MST1 ameliorates neuronal apoptosis via GSK3β/β-TrCP/NRF2 pathway in spinal cord injury accompanied by diabetes.

MST1 MST1L

9.37e-06362238430683
Pubmed

Macrophage stimulating protein is a target-derived neurotrophic factor for developing sensory and sympathetic neurons.

MST1 MST1L

9.37e-06362212538524
Pubmed

Mst1 controls lymphocyte trafficking and interstitial motility within lymph nodes.

MST1 MST1L

9.37e-06362219339990
Pubmed

TRAF2 functions as an activator switch in the reactive oxygen species-induced stimulation of MST1.

MST1 MST1L

9.37e-06362226698664
Pubmed

Melatonin activates Parkin translocation and rescues the impaired mitophagy activity of diabetic cardiomyopathy through Mst1 inhibition.

MST1 MST1L

9.37e-06362230063115
Pubmed

Mst1-mediated phosphorylation of Bcl-xL is required for myocardial reperfusion injury.

MST1 MST1L

9.37e-06362227218122
Pubmed

Inhibition of endogenous Mst1 prevents apoptosis and cardiac dysfunction without affecting cardiac hypertrophy after myocardial infarction.

MST1 MST1L

9.37e-06362217395874
Pubmed

Genetic deletion of Mst1 alters T cell function and protects against autoimmunity.

MST1 MST1L

9.37e-06362224852423
Pubmed

Mst1 participates in the atherosclerosis progression through macrophage autophagy inhibition and macrophage apoptosis enhancement.

MST1 MST1L

9.37e-06362227496379
Pubmed

Macrophage-stimulating protein cooperates with erythropoietin to induce colony formation and MAP kinase activation in primary erythroid progenitor cells.

MST1 MST1L

9.37e-06362212804176
Pubmed

Receptor tyrosine kinase Ron is expressed in mouse reproductive tissues during embryo implantation and is important in trophoblast cell function.

MST1 MST1L

9.37e-06362212606483
Pubmed

Exome sequencing identifies mutations in CCDC114 as a cause of primary ciliary dyskinesia.

DNAI2 DNAH5

9.37e-06362223261302
Pubmed

Mst1-mediated phosphorylation of Nur77 improves the endometrial receptivity in human and mice.

MST1 MST1L

9.37e-06362236623453
Pubmed

Hippo Kinase MST1-Mediated Cell Metabolism Reprograms the Homeostasis and Differentiation of Granulocyte Progenitor Cells.

MST1 MST1L

9.37e-06362237184367
Pubmed

CircRbms1 fosters MST1 mRNA and protein levels to motivate myocardial ischaemia-reperfusion injury via autophagic status.

MST1 MST1L

9.37e-06362238288506
Pubmed

The proto-oncogene RON is involved in development of epithelial, bone and neuro-endocrine tissues.

MST1 MST1L

9.37e-0636228545120
Pubmed

Hepatocyte growth factor-like protein is a positive regulator of early mammary gland ductal morphogenesis.

MST1 MST1L

9.37e-06362225049204
Pubmed

Characterization of the mouse cDNA and gene coding for a hepatocyte growth factor-like protein: expression during development.

MST1 MST1L

9.37e-0636221832957
Pubmed

Activation of pro-survival CaMK4β/CREB and pro-death MST1 signaling at early and late times during a mouse model of prion disease.

MST1 MST1L

9.37e-06362225183307
Pubmed

MST1 mediates neuronal loss and cognitive deficits: A novel therapeutic target for Alzheimer's disease.

MST1 MST1L

9.37e-06362235525373
Pubmed

MST1 coordinately regulates autophagy and apoptosis in diabetic cardiomyopathy in mice.

MST1 MST1L

9.37e-06362227510910
Pubmed

Combination of melatonin and irisin ameliorates lipopolysaccharide-induced cardiac dysfunction through suppressing the Mst1-JNK pathways.

MST1 MST1L

9.37e-06362231976559
Pubmed

Over-expressed MST1 impaired spatial memory via disturbing neural oscillation patterns in mice.

MST1 MST1L

9.37e-06362232468668
Pubmed

Nicorandil alleviates myocardial injury and post-infarction cardiac remodeling by inhibiting Mst1.

MST1 MST1L

9.37e-06362229127009
Pubmed

Mst1 Kinase Regulates the Actin-Bundling Protein L-Plastin To Promote T Cell Migration.

MST1 MST1L

9.37e-06362227465533
Pubmed

Suramin protects hepatocytes from LPS-induced apoptosis by regulating mitochondrial stress and inactivating the JNK-Mst1 signaling pathway.

MST1 MST1L

9.37e-06362230771091
Pubmed

MST1 mediates the N-methyl-D-aspartate-induced excitotoxicity in mouse cortical neurons.

MST1 MST1L

9.37e-06362234967918
Pubmed

Hippo kinases Mst1 and Mst2 maintain NK cell homeostasis by orchestrating metabolic state and transcriptional activity.

MST1 MST1L

9.37e-06362238898027
Pubmed

WASP and Mst1 coregulate B-cell development and B-cell receptor signaling.

MST1 MST1L

9.37e-06362232045478
Pubmed

Impaired liver regeneration in aged mice can be rescued by silencing Hippo core kinases MST1 and MST2.

MST1 MST1L

9.37e-06362227940445
Pubmed

Inhibition of TLR4-induced IκB kinase activity by the RON receptor tyrosine kinase and its ligand, macrophage-stimulating protein.

MST1 MST1L

1.87e-05462221078906
Pubmed

MST1 controls murine neutrophil homeostasis via the G-CSFR/STAT3 axis.

MST1 MST1L

1.87e-05462236618429
Pubmed

Hyperglycemia-Induced Overexpression of PH Domain Leucine-Rich Repeat Protein Phosphatase 1 (PHLPP1) Compromises the Cardioprotective Effect of Ischemic Postconditioning Via Modulation of the Akt/Mst1 Pathway Signaling.

MST1 MST1L

1.87e-05462235715527
Pubmed

Rab13 acts downstream of the kinase Mst1 to deliver the integrin LFA-1 to the cell surface for lymphocyte trafficking.

MST1 MST1L

1.87e-05462225074980
Pubmed

OSM mitigates post-infarction cardiac remodeling and dysfunction by up-regulating autophagy through Mst1 suppression.

MST1 MST1L

1.87e-05462227825852
Pubmed

MST1 deficiency promotes B cell responses by CD4+ T cell-derived IL-4, resulting in hypergammaglobulinemia.

MST1 MST1L

1.87e-05462228527887
Pubmed

Mst1 directs Myosin IIa partitioning of low and higher affinity integrins during T cell migration.

MST1 MST1L

1.87e-05462225133611
Pubmed

LncRNA SNHG17 knockdown promotes Parkin-dependent mitophagy and reduces apoptosis of podocytes through Mst1.

MST1 MST1L

1.87e-05462232627655
Pubmed

Macrophage MST1/2 Disruption Impairs Post-Infarction Cardiac Repair via LTB4.

MST1 MST1L

1.87e-05462234515499
Pubmed

The Mst1 and Mst2 kinases control activation of rho family GTPases and thymic egress of mature thymocytes.

MST1 MST1L

1.87e-05462222412158
Pubmed

Trp(56) of rac1 specifies interaction with a subset of guanine nucleotide exchange factors.

TIAM1 TRIO

1.87e-05462211595749
Pubmed

Functional role of Mst1/Mst2 in embryonic stem cell differentiation.

MST1 MST1L

1.87e-05462224224013
Pubmed

Mst1 regulates hepatic lipid metabolism by inhibiting Sirt1 ubiquitination in mice.

MST1 MST1L

1.87e-05462226903296
Pubmed

Glyceraldehyde-3-phosphate dehydrogenase interacts with proapoptotic kinase mst1 to promote cardiomyocyte apoptosis.

MST1 MST1L

1.87e-05462223527007
Pubmed

A cell-intrinsic role for Mst1 in regulating thymocyte egress.

MST1 MST1L

1.87e-05462219692642
Pubmed

Melatonin protects against diabetic cardiomyopathy through Mst1/Sirt3 signaling.

MST1 MST1L

1.87e-05462228480597
Pubmed

Spatiotemporal regulation of the kinase Mst1 by binding protein RAPL is critical for lymphocyte polarity and adhesion.

MST1 MST1L

1.87e-05462216892067
Pubmed

Hippo signaling pathway reveals a spatio-temporal correlation with the size of primordial follicle pool in mice.

MST1 MST1L

1.87e-05462225659841
Pubmed

Mammalian Sterile 20-like Kinase 1 (Mst1) Enhances the Stability of Forkhead Box P3 (Foxp3) and the Function of Regulatory T Cells by Modulating Foxp3 Acetylation.

MST1 MST1L

1.87e-05462226538561
Pubmed

MST1 functions as a key modulator of neurodegeneration in a mouse model of ALS.

MST1 MST1L

1.87e-05462223818595
Pubmed

RON (MST1R) and HGFL (MST1) Co-Overexpression Supports Breast Tumorigenesis through Autocrine and Paracrine Cellular Crosstalk.

MST1 MST1L

1.87e-05462235626096
Pubmed

Mammalian sterile 20-like kinase 1 suppresses lymphoma development by promoting faithful chromosome segregation.

MST1 MST1L

1.87e-05462222926556
Pubmed

Treatment with Mammalian Ste-20-like Kinase 1/2 (MST1/2) Inhibitor XMU-MP-1 Improves Glucose Tolerance in Streptozotocin-Induced Diabetes Mice.

MST1 MST1L

1.87e-05462232987643
Pubmed

The Mst1 Kinase Is Required for Follicular B Cell Homing and B-1 B Cell Development.

MST1 MST1L

1.87e-05462230386341
Pubmed

A combination of SILAC and nucleotide acyl phosphate labelling reveals unexpected targets of the Rsk inhibitor BI-D1870.

MST1 MST1L

1.87e-05462227919044
Pubmed

Mst1/2 Kinases Modulate Glucose Uptake for Osteoblast Differentiation and Bone Formation.

MST1 MST1L

1.87e-05462229474739
Pubmed

DNAI2 mutations cause primary ciliary dyskinesia with defects in the outer dynein arm.

DNAI2 DNAH5

1.87e-05462218950741
Pubmed

Macrophage-stimulating protein, the ligand for the stem cell-derived tyrosine kinase/RON receptor tyrosine kinase, inhibits IL-12 production by primary peritoneal macrophages stimulated with IFN-gamma and lipopolysaccharide.

MST1 MST1L

1.87e-05462214734766
Pubmed

Thioredoxin-1 functions as a molecular switch regulating the oxidative stress-induced activation of MST1.

MST1 MST1L

1.87e-05462223085515
Pubmed

The RNA binding protein MEX3A promotes tumor progression of breast cancer by post-transcriptional regulation of IGFBP4.

ASXL1 PARP1 TRIO AHNAK AHCTF1 DNAH5

2.84e-0533262637433992
Pubmed

Mst1 regulates integrin-dependent thymocyte trafficking and antigen recognition in the thymus.

MST1 MST1L

3.12e-05562223033074
Pubmed

Assignment of the gene coding for hepatocyte growth factor-like protein to mouse chromosome 9.

MST1 MST1L

3.12e-0556221354648
Pubmed

Mst1 inhibits Sirt3 expression and contributes to diabetic cardiomyopathy through inhibiting Parkin-dependent mitophagy.

MST1 MST1L

3.12e-05562229674007
Pubmed

Tubule-Specific Mst1/2 Deficiency Induces CKD via YAP and Non-YAP Mechanisms.

MST1 MST1L

3.12e-05562232253273
Pubmed

RNF17, a component of the mammalian germ cell nuage, is essential for spermiogenesis.

TDRD6 RNF17

3.12e-05562216093322
Pubmed

ARMC4 mutations cause primary ciliary dyskinesia with randomization of left/right body asymmetry.

DNAI2 DNAH5

3.12e-05562223849778
Pubmed

Hippo signaling is a potent in vivo growth and tumor suppressor pathway in the mammalian liver.

MST1 MST1L

3.12e-05562220080689
Pubmed

The Nore1B/Mst1 complex restrains antigen receptor-induced proliferation of naïve T cells.

MST1 MST1L

3.12e-05562219073936
Pubmed

Mst1-Deficiency Induces Hyperactivation of Monocyte-Derived Dendritic Cells via Akt1/c-myc Pathway.

MST1 MST1L

3.12e-05562231572367
InteractionRAB40AL interactions

RAB40AL RAB40C RAB40B RAB40A

1.35e-0716614int:RAB40AL
InteractionLRRC31 interactions

PARP1 ARHGEF40 TIAM1 TRIO AHNAK TUT7 RICTOR ADPGK

1.85e-07205618int:LRRC31
GeneFamilyMOB kinase activators|STRIPAK complex

MOB3C MOB3A

1.26e-047452647
GeneFamilyRAB, member RAS oncogene GTPases

RAB40C RAB40B RAB40A

5.65e-0465453388
GeneFamilyPleckstrin homology domain containing|Rho guanine nucleotide exchange factors|C2 domain containing

ARHGEF40 TIAM1 TRIO

5.91e-0466453722
GeneFamilyDyneins, axonemal

DNAI2 DNAH5

8.04e-0417452536
GeneFamilyNucleoporins

AHCTF1 NUP54

2.87e-03324521051
GeneFamilyTudor domain containing

TDRD6 RNF17

3.82e-0337452780
GeneFamilyWD repeat domain containing

WDR88 DNAI2 WSB2 EML3

4.03e-03262454362
GeneFamilyBlood group antigens|CD molecules|I-set domain containing|Immunoglobulin like domain containing

TRIO UNC5C CNTN2

7.48e-03161453593
GeneFamilyPleckstrin homology domain containing|Rho guanine nucleotide exchange factors|C2 domain containing

TIAM1 DGKH PLEKHA7

1.46e-02206453682
CoexpressionLAKE_ADULT_KIDNEY_C11_THIN_ASCENDING_LIMB

TRIO LAMB1 PLEKHA7 DNAH5 PCDH9 CDH16

3.00e-06169626M39230
ToppCell15-Distal-Epithelial-Multiciliated_cell|Distal / Age, Tissue, Lineage and Cell class

CFAP95 MB DNAI2 AGBL2 DNAH5

3.84e-06169625425d89ab69e9f9eb3df84056676423e390cc6ab1
ToppCell21-Trachea-Epithelial-Intermediate_ciliated|Trachea / Age, Tissue, Lineage and Cell class

CFAP95 MB DNAI2 AGBL2 DNAH5

6.28e-061876251a2178a195d078d1963947b327c6d0d4f2f48341
ToppCellwk_20-22-Epithelial-Proximal_epithelial-MUC16+_ciliated|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

CFAP95 MB DNAI2 AGBL2 DNAH5

7.50e-06194625756082a0f5953b52229bb60d40b84701cb6cb23d
ToppCell3'-GW_trimst-1.5-LargeIntestine-Endothelial-blood_vessel_EC-Fetal_venous_EC|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

VWF TIAM1 PLXND1 TDRD6

7.32e-0516062433050dc646762dc7e9dcc4a12c618e1ba1ce5a4d
ToppCellRSV-Healthy-6|Healthy / Virus stimulation, Condition and Cluster

MST1 ADAM19 CAMKK1 AGBL2

8.05e-051646241b9c5a6dc4e09b90f92e98b81a5ee620f8479cc7
ToppCellRSV-Healthy-6|RSV / Virus stimulation, Condition and Cluster

MST1 ADAM19 CAMKK1 AGBL2

8.05e-05164624ab312b8c2f828ea7331f2a340c4df81587a23b5c
ToppCell15-Distal-Epithelial-Multiciliated_precursor|Distal / Age, Tissue, Lineage and Cell class

CFAP95 MB DNAI2 DNAH5

8.64e-05167624442ea71a581ed5a547a214132b9f1b0243fd0895
ToppCell3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.0.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DNAI2 DGKH AGBL2 DNAH5

9.04e-0516962414aadc2d1bf66eb47dac33b4d61ddb3c942caa4f
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

TRIO LAMB1 DGKH DNAH5

9.68e-051726240c2d0bb767e5ce089b42ad49e8b303a103de2d5c
ToppCellwk_08-11-Epithelial-Proximal_epithelial-Deuterosomal|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

CFAP95 MB DNAI2 DNAH5

9.68e-0517262408ad76412c9cc3504141797b44b88478ced87476
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

TRIO LAMB1 DGKH DNAH5

9.68e-05172624eeed177a03c116e9815a8e086d24efc9643b16a4
ToppCell3'-Distal_airway-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.3.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CFAP95 DNAI2 ARHGAP39 DNAH5

9.90e-05173624c3762655caa79ac4879876f470d32578a3c93b01
ToppCellPCW_10-12-Epithelial-Epithelial_ciliated|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

CFAP95 MB DNAI2 DNAH5

1.01e-04174624b8d1c556290d188f56aeefc17f03119686945fe7
ToppCellPCW_10-12-Epithelial-Epithelial_ciliated-epi_ciliated_(14)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

CFAP95 MB DNAI2 DNAH5

1.01e-0417462400cf27bc23af1472a507be31fba6245a8fdd901b
ToppCellPCW_13-14-Epithelial-Epithelial_ciliated|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

CFAP95 MB DNAI2 DNAH5

1.03e-04175624b1369d2b74f461e6822d0c33e9b50fe0dfbceb54
ToppCellPCW_13-14-Epithelial-Epithelial_ciliated-epi_ciliated_(14)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

CFAP95 MB DNAI2 DNAH5

1.03e-04175624c82ec6deb6ccdd991a69a62b6d62d5b14c803d7a
ToppCellfacs-Trachea-3m-Epithelial-airway_epithelial-tracheobronchial_ciliated_cell-ciliated_cell|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

MST1 CFAP95 DNAI2 DNAH5

1.08e-041776243cfde67b93f3986312f5e74e42504214d966e7dc
ToppCellfacs-Trachea-3m-Epithelial-airway_epithelial-tracheobronchial_ciliated_cell|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

MST1 CFAP95 DNAI2 DNAH5

1.08e-0417762412a52a12a87a31e501ced611f46a90d172ca7e35
ToppCellfacs-Trachea-nan-3m-Epithelial-ciliated_columnar_cell_of_tracheobronchial_tree|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MST1 CFAP95 DNAI2 DNAH5

1.15e-04180624cf6e9f757afeb342c5023f6e6152a1b4d0d164b4
ToppCellwk_08-11-Epithelial-Proximal_epithelial-Ciliated|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

CFAP95 MB DNAI2 DNAH5

1.18e-041816248eed9d46d924b16f6dd1a025ff612244b02b4391
ToppCell10x5'-Liver-Lymphocytic_T_CD4-T_CD4/CD8|Liver / Manually curated celltypes from each tissue

ADAM19 AHNAK TNRC6B DGKH

1.18e-04181624f2315414e714ac86211546a935660c4be6e85f1b
ToppCellControl-Epithelial_cells-Airway_ciliated|Control / group, cell type (main and fine annotations)

CFAP95 DNAI2 AGBL2 DNAH5

1.20e-04182624fb725d10d9ed25dfc6d5bb69cfef78513f7d3e8f
ToppCell367C-Lymphocytic-NK_cells-Proliferating_NK_cell|NK_cells / Donor, Lineage, Cell class and subclass (all cells)

ADAM19 WSB2 DGKH CCNA2

1.23e-04183624a716b446c2bf5aa294b8f580aa845098fae76354
ToppCellCiliated_cells-B-IPF_02|World / lung cells shred on cell class, cell subclass, sample id

CFAP95 MB DNAI2 AGBL2

1.28e-041856244fc7113d3dadc716ec5a8e62b58543cc00ce5b16
ToppCellNS-moderate-d_16-33-Epithelial-Ciliated|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

DNAI2 ARHGAP39 AGBL2 DNAH5

1.28e-041856245e689c2fb36ce3ac2adc8d15f67107f21cf68868
ToppCellCiliated_cells-B-Myositis-ILD_01|World / lung cells shred on cell class, cell subclass, sample id

CFAP95 DNAI2 AGBL2 DNAH5

1.28e-04185624f012c243343e1d1956db19b34d062e9b13de2b2a
ToppCell15-Airway-Epithelial-Multiciliated_cell|Airway / Age, Tissue, Lineage and Cell class

CFAP95 DNAI2 AGBL2 DNAH5

1.28e-041856240998b6bf44287eebbf39249fff23fc3689e44c4e
ToppCellAdult-Epithelial-ciliated_cell-D175|Adult / Lineage, Cell type, age group and donor

CFAP95 DNAI2 ARHGAP39 AGBL2

1.28e-0418562430f4980dee6cd5959655f8d74049f3bfb5312611
ToppCellCOVID-19-Epithelial_cells-Airway_ciliated|COVID-19 / group, cell type (main and fine annotations)

CFAP95 DNAI2 AGBL2 DNAH5

1.28e-0418562418a40f0a338aa398d81384b5159fb80ce8a2020c
ToppCell3'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-pericyte_cell-Pericytes-Pericytes_L.2.3.3.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

UNC5C LAMB1 ABCC9 DGKH

1.31e-04186624888e85a025bd982d36c910db0f5a3385b1ca3b28
ToppCell10x3'2.3-week_17-19-Endothelial-stroma-proliferating_EC|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

VWF DGKH PLXND1 TDRD6

1.31e-04186624a844d4f79e0ad5d6c60a4488ffd8f4f21b7eed04
ToppCellP15-Epithelial-airway_epithelial_cell-club_cell|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

CFAP95 DNAI2 AGBL2 DNAH5

1.34e-04187624a70aaae32426e9ddb1cbfbd0e0db24ccc96b9f40
ToppCell5'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.3.1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CFAP95 DNAI2 AGBL2 DNAH5

1.34e-04187624e61992de4f98eeea08b43213850769d923f8db48
ToppCell10x5'-GI_small-bowel-Lymphocytic_T_CD4-T_CD4/CD8|GI_small-bowel / Manually curated celltypes from each tissue

AHCTF1 TNRC6B RICTOR DGKH

1.36e-04188624ab9b725d6e0cdab8e9ddda6dee09e14730e9a578
ToppCell21-Trachea-Epithelial-Multiciliated_cell|Trachea / Age, Tissue, Lineage and Cell class

CFAP95 DNAI2 AGBL2 DNAH5

1.36e-04188624803bf76a85b3033d2a04b08dd2c03ce9c15529ba
ToppCellP15-Epithelial-airway_epithelial_cell|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

CFAP95 DNAI2 AGBL2 DNAH5

1.36e-04188624e3e71c0f2e374330620cb4d27638953ffa9f5298
ToppCellPND01-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Ciliated-Ciliated_mature|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CFAP95 DNAI2 AGBL2 DNAH5

1.39e-04189624b55de812043b670cbde810d7d42f45909b6d66ef
ToppCelldroplet-Lung-immune-endo-depleted-3m-Epithelial-ciliated_columnar_cell_of_tracheobronchial_tree|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CFAP95 DNAI2 AGBL2 DNAH5

1.39e-0418962428c750ac56e3861fe7280e32839a4d8ce8bd8692
ToppCelldroplet-Lung-immune-endo-depleted-3m-Epithelial-Ciliated_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CFAP95 DNAI2 AGBL2 DNAH5

1.39e-04189624efee01edd171bf569267b672fab05c421de6c92d
ToppCellPND01-Epithelial-Epithelial_Airway|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CFAP95 DNAI2 AGBL2 DNAH5

1.39e-0418962438cde34295566a4ecaf7d0a81c5a192cf17d0459
ToppCellMesenchymal-pericyte_cell|World / Lineage, Cell type, age group and donor

UNC5C LAMB1 ABCC9 DGKH

1.39e-04189624d7ed96add29f219183c802895fbff519b627f635
ToppCellPND01-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Ciliated|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CFAP95 DNAI2 AGBL2 DNAH5

1.39e-041896244e83e49d1265ffe507fdb72924c77c4d1c73f0bd
ToppCellfacs-Lung-18m-Epithelial-airway_epithelial-lung_ciliated_cell-ciliated_cell|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

CFAP95 DNAI2 AGBL2 DNAH5

1.42e-041906249ffd18ef358f8e32c610ab6420f479067c8ba44b
ToppCellfacs-Lung-18m-Epithelial-airway_epithelial-lung_ciliated_cell|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

CFAP95 DNAI2 AGBL2 DNAH5

1.42e-041906243ef39d61c98de4e5df946b995847aa65eba6a4b6
ToppCellfacs-Lung-3m-Epithelial-airway_epithelial-lung_ciliated_cell-ciliated_cell|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

CFAP95 DNAI2 AGBL2 DNAH5

1.45e-04191624649fcb62ad15de2f83e61591e43923a717664ae7
ToppCellcontrol-Myeloid-Neutrophils_1|Myeloid / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

ARHGEF40 AHCTF1 MPZL1 RICTOR

1.45e-04191624db1b3cd07d7d190155b2d14e82e1d124975fbd0b
ToppCellfacs-Lung-3m-Epithelial-airway_epithelial-lung_ciliated_cell|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

CFAP95 DNAI2 AGBL2 DNAH5

1.45e-041916249621e22e14ea069f22713947c9faa2d882abe5fe
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

TRIO LAMB1 DGKH DNAH5

1.45e-04191624d0e9afe7b6334dd515d3e68892efdc76347a55e5
ToppCellPND03-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Ciliated|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CFAP95 DNAI2 AGBL2 DNAH5

1.45e-04191624bda8faf92495c8b362850c0aff4fc6fbdd9c563b
ToppCellPND03-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Ciliated-Ciliated_mature|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CFAP95 DNAI2 AGBL2 DNAH5

1.45e-041916246880fb348bb0915db9a5da4f3566ca9ff93ed258
ToppCellASK428-Epithelial-Ciliated|ASK428 / Donor, Lineage and Cell class of Lung cells from Dropseq

CFAP95 DNAI2 AGBL2 DNAH5

1.45e-041916240c4b926a28bc94f3cf4d68a911c0a189f6ff505e
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

TRIO DGKH DNAH5 PCDH9

1.45e-041916249032aa974aa1b7b1095b8d1b58dcb087358a5001
ToppCellwk_15-18-Epithelial-Proximal_epithelial-MUC16+_ciliated|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

CFAP95 MB DNAI2 DNAH5

1.45e-04191624e81cd65dbf0ef1c2ab7088f73ce605d456dd3a7a
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

TRIO DGKH DNAH5 PCDH9

1.45e-041916245717809a1476c20f65bce722c5a57cff92ee0d7a
ToppCellPND01-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CFAP95 DNAI2 AGBL2 DNAH5

1.45e-0419162496483adb97c81208aa513782550acd8a08b63866
ToppCellproximal-Hematologic-Platelet/Megakaryocyte|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

TRIO MB RAB40AL PLEKHA7

1.48e-04192624522d1bb15edf1d6006b80289bd3baadb99584ae8
ToppCellproximal-3-Hematologic-Platelet/Megakaryocyte|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

TRIO MB RAB40AL PLEKHA7

1.48e-04192624f5f83dec37dff32a0c471cb05d23d13b0b0ad0c9
ToppCellPND03-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CFAP95 DNAI2 AGBL2 DNAH5

1.48e-04192624b5cdc2dae3154b1e4ade88f841f38584402ffe33
ToppCellproximal-Hematologic-Platelet/Megakaryocyte-3|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

TRIO MB RAB40AL PLEKHA7

1.48e-0419262457899a905ca3e336bb7f31edc6418a2546b9891a
ToppCell10x_3'_v2v3-Non-neoplastic-Glial-Neuronal-Oligodendrocyte-Oligodendrocyte-C|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

UNC5C RAB40B PCDH9 CNTN2

1.48e-041926243ce5dbde41aeb73d49f2c7991d34682f0827fa5a
ToppCellPND03-Epithelial-Epithelial_Airway|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CFAP95 DNAI2 AGBL2 DNAH5

1.48e-041926242d8d5a38e205339eda9c8aca1ca9ba3dcbe5ae56
ToppCellfacs-Large_Intestine-Distal-3m-Epithelial-Reg4/cKit+_deep_crypt_secretory_cells_(Distal)|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ARHGEF40 MPZL1 ZNF25 PCSK9

1.51e-041936244aee372ba2c0351b0221d0d468707d1ad21526d6
ToppCellfacs-Large_Intestine-Distal-3m-Epithelial-secretory_cell|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ARHGEF40 MPZL1 ZNF25 PCSK9

1.51e-04193624aaa5042388dc451bff384c6bb237348f08280a08
ToppCellASK440-Epithelial-Ciliated|ASK440 / Donor, Lineage and Cell class of Lung cells from Dropseq

CFAP95 DNAI2 AGBL2 DNAH5

1.51e-04193624a0baa8be6f590b2031fede22be588715ae458e93
ToppCelldistal-Epithelial-Proximal_Ciliated|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

CFAP95 MB DNAI2 AGBL2

1.57e-04195624abe7998421dc59bdae35c0c2251c4a1ebef5e021
ToppCelldistal-Epithelial-Proximal_Ciliated-3|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

CFAP95 MB DNAI2 AGBL2

1.57e-041956240e3f74e0877d33c11f048b9be8394596cf5c9c4c
ToppCellsaliva-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_B-B_cell-B_c02-MS4A1-CD27|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

ASXL1 PARP1 ADAM19 NUP54

1.60e-041966240175b097ad1338a07afebe3b5c7fd0bb0bb950f7
ToppCell10x3'2.3-week_17-19-Endothelial-stroma-sinusoidal_EC|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

VWF LAMB1 ABCC9 PLXND1

1.63e-041976244e58bbf3ecb30b4c8199adcc04d2eb134d90de56
ToppCell10x3'2.3-week_17-19-Endothelial-stroma-tip_EC|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

VWF LAMB1 DGKH PLXND1

1.63e-04197624b212ff28ca2d1fea4140f186ab90941bdca21249
ToppCelldistal-3-Epithelial-Proximal_Ciliated|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

CFAP95 DNAI2 AGBL2 DNAH5

1.63e-0419762415b4d1203943ce90a7083178d4a4284d9b323071
ToppCell10x3'2.3-week_17-19-Endothelial|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

VWF LAMB1 DGKH PLXND1

1.66e-041986242630a7a6e56febe5c0b0bde70dd7292fa1650c47
ToppCellIPF-Endothelial-VE_Peribronchial|Endothelial / Disease state, Lineage and Cell class

VWF TRIO AHCTF1 PLEKHA7

1.66e-04198624b8bd1ba268480f54451648e01631b615a3401144
ToppCell10x3'2.3-week_17-19-Endothelial-stroma|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

VWF LAMB1 DGKH PLXND1

1.66e-041986241e83bec16dcd60460422625f89952ff506d6be51
ToppCell10x3'2.3-week_14-16-Endothelial|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

VWF LAMB1 ABCC9 PLXND1

1.69e-0419962441f046646fff65b7e51b63d3204f76ef32054781
ToppCellBronchial-10x5prime-Epithelial-Epi_airway_ciliated-Deuterosomal|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

MB DNAI2 RAB40A AGBL2

1.69e-0419962492778939e9d06599c7d06cfd8f4362b97ed0606b
ToppCellNon-neuronal-Postmitotic-Endothelial|World / Primary Cells by Cluster

VWF AHNAK ABCC9 PLXND1

1.69e-04199624b9763ac9857a60db6f1f104fe1e9ea2266cf931b
ToppCellNon-neuronal-Postmitotic-Endothelial-Endothelial-24|World / Primary Cells by Cluster

VWF AHNAK ABCC9 PLXND1

1.69e-041996240b4edf3e359749827ef978a77b5267ddde732d71
ToppCellNon-neuronal-Postmitotic-Endothelial-Endothelial|World / Primary Cells by Cluster

VWF AHNAK ABCC9 PLXND1

1.69e-041996249e01eee126247a0696c71b019f855a8a41a0ede3
ToppCell10x3'2.3-week_14-16-Endothelial-stroma|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

VWF LAMB1 ABCC9 PLXND1

1.69e-04199624ef7f7f7c861827574b120f48cf4052c563929081
ToppCell(10)_Ciliated|World / shred by cell type by condition

CFAP95 DNAI2 AGBL2 DNAH5

1.73e-042006241b6a8025bd2746b626040058c122b1be3ab2fa61
ToppCellBiopsy_Control_(H.)-Epithelial-Ciliated|Biopsy_Control_(H.) / Sample group, Lineage and Cell type

CFAP95 DNAI2 AGBL2 DNAH5

1.73e-042006249ae434c78e08adf95da49c85616e3ca72d1227bf
ToppCellLPS_IL1RA-Endothelial-Endothelial-Gen_Cap|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

TAOK2 VWF TRIO DGKH

1.73e-04200624dccec522ab0d7fff62ad6273b02aa9022dbbb8eb
ToppCellBronchial-10x5prime-Epithelial-Epi_airway_ciliated|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

CFAP95 DNAI2 AGBL2 DNAH5

1.73e-0420062452aef65f01b06cd98056f17977efe525aee6eb6f
ToppCellBronchial-10x5prime-Epithelial-Epi_airway_ciliated-Ciliated|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

CFAP95 DNAI2 AGBL2 DNAH5

1.73e-0420062455c148238d5c80c1faa3428a917ae8075be2c145
ToppCell10x5'v1-week_14-16-Endothelial-stroma|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

VWF LAMB1 ABCC9 PLXND1

1.73e-042006242488aa12970a43a5af352e2c36c73884d73a1cc5
ToppCell10x5'v1-week_14-16-Endothelial-stroma-tip_EC|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

VWF LAMB1 ABCC9 PLXND1

1.73e-0420062477ac1aa73c16a4f595ff01c6b4e171e0b8fed1e6
ToppCellTracheal-10x5prime-Epithelial-Epi_airway_ciliated|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

CFAP95 DNAI2 AGBL2 DNAH5

1.73e-0420062431d75c26055177d656df1fbb10b764cebd61e122
ToppCellBiopsy_Other_PF-Epithelial-Ciliated|Biopsy_Other_PF / Sample group, Lineage and Cell type

CFAP95 DNAI2 AGBL2 DNAH5

1.73e-04200624721371698bce8890853fb6b6b01a2c20293b39e9
ToppCellBiopsy_Control_(H.)-Epithelial-Differentiating_Ciliated|Biopsy_Control_(H.) / Sample group, Lineage and Cell type

CFAP95 MB DNAI2 DNAH5

1.73e-04200624a552a99f5e4fa00dfb7775e5a3e1f62f1530d104
ToppCell(09)_Interm._secr.>cil.|World / shred by cell type by condition

CFAP95 DNAI2 AGBL2 DNAH5

1.73e-042006243305e14dba12e94da42f0414fdc7a2c8caf0a183
ToppCellTracheal-10x5prime-Epithelial-Epi_airway_ciliated-Ciliated|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

CFAP95 DNAI2 AGBL2 DNAH5

1.73e-04200624e1dce91c6c531bb212002a14705e496d77ad3490
ToppCellBiopsy_IPF|World / Sample group, Lineage and Cell type

CFAP95 DNAI2 AGBL2 DNAH5

1.73e-042006244de8c4789fb64250cb1dca94c108d39ab119bab4
ToppCell10x5'v1-week_14-16-Endothelial|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

VWF LAMB1 ABCC9 PLXND1

1.73e-04200624e786544cf6f891550c4be55ebb4928c92297b504
ToppCellCerebellum-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Pvalb-Inhibitory_Neuron.Gad1Gad2.Pvalb-Chrm2_(Cerebellum_basket_cells_4)|Cerebellum / BrainAtlas - Mouse McCarroll V32

INSRR GCKR TFR2

1.90e-048062354f520cca126810510479fbeade2e3f66fb5dd1b
ToppCellCerebellum-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Pvalb-Inhibitory_Neuron.Gad1Gad2.Pvalb-Chrm2_(Cerebellum_basket_cells_4)-|Cerebellum / BrainAtlas - Mouse McCarroll V32

INSRR GCKR TFR2

1.90e-0480623ce38ea123853a1e1082a033fb779b63ea440661d
ToppCell368C-Lymphocytic-NK_cells-NK_cell_E|NK_cells / Donor, Lineage, Cell class and subclass (all cells)

MOB3A PCDH9 NUP54

2.52e-0488623142d2e00ef19c0ad011a21945bf1111271056eae
DrugLomefloxacin hydrochloride [98079-52-8]; Up 200; 10.4uM; PC3; HT_HG-U133A

WIZ AHNAK DNAI2 RAB40C ABCC9 PLXND1

1.55e-051966264281_UP
DrugEnoxacin [74011-58-8]; Up 200; 12.4uM; MCF7; HT_HG-U133A

TAOK2 TAPBPL DNAI2 AGBL2 PCDH9 VEGFB

1.60e-051976265616_UP
Drugdiclofenac sodium; Up 200; 10uM; MCF7; HG-U133A

ASXL1 ADAM19 TUT7 DNAI2 GCKR PLXND1

1.64e-05198626333_UP
DrugEpiandrosterone [481-29-8]; Up 200; 13.8uM; MCF7; HT_HG-U133A

TAOK2 ADAM19 TIAM1 TRIO GCKR AGBL2

1.69e-051996263306_UP
Drugarachidonic acid sodium salt; Down 200; 10uM; MCF7; HG-U133A

WIZ TRIO TUT7 MPZL1 GCKR TFR2

1.74e-05200626604_DN
Diseaseresponse to bevacizumab, Proteinuria

TRIO DNAH5

3.92e-055592EFO_0005943, HP_0000093
Diseasechemotherapy-induced alopecia, methylcobalamin deficiency type cblE

TRIO DNAH5

1.09e-048592EFO_0005400, MONDO_0009354
Diseasetriglycerides to total lipids in small VLDL percentage

GCKR PCSK9 VEGFB

2.17e-0458593EFO_0022338
Diseasereticulocyte measurement

VWF WIZ AHNAK TUT7 TNRC6B RICTOR GCKR PLEKHA7 TFR2

2.29e-041053599EFO_0010700
Diseasecholesterol to total lipids in IDL percentage

GCKR PCSK9 VEGFB

2.40e-0460593EFO_0022233
Diseasetriglycerides to total lipids in IDL percentage

GCKR PCSK9 VEGFB

2.77e-0463593EFO_0022329
Diseasetransient cerebral ischemia (implicated_via_orthology)

PARP1 VWF PLXND1

2.90e-0464593DOID:224 (implicated_via_orthology)
Diseasecholesterol to total lipids in very small VLDL percentage

GCKR PCSK9 VEGFB

3.32e-0467593EFO_0022245
DiseaseKartagener syndrome (implicated_via_orthology)

DNAI2 DNAH5

3.52e-0414592DOID:0050144 (implicated_via_orthology)
Diseasecholesteryl esters to total lipids in very small VLDL percentage

GCKR PCSK9 VEGFB

3.94e-0471593EFO_0022259
Diseasefree cholesterol to total lipids in small VLDL percentage

GCKR PCSK9 VEGFB

4.63e-0475593EFO_0022287
Diseasemethylcobalamin deficiency type cblE, brain serotonin transporter measurement

VWF TRIO

4.63e-0416592EFO_0004569, MONDO_0009354
Diseaseprimary ciliary dyskinesia (implicated_via_orthology)

DNAI2 DNAH5

6.58e-0419592DOID:9562 (implicated_via_orthology)
Diseaseselenium measurement, response to dietary selenium supplementation

TRIO DNAH5

7.30e-0420592EFO_0006331, EFO_0600021
DiseaseBronchiectasis

DNAI2 DNAH5

8.85e-0422592C0006267
Diseasevascular endothelial function measurement

DNAI2 RICTOR TFR2

1.04e-0399593EFO_0803369
Diseaseinflammatory bowel disease (implicated_via_orthology)

MST1 MST1L

1.14e-0325592DOID:0050589 (implicated_via_orthology)
Diseasetriacylglycerol 56:7 measurement

AHCTF1 GCKR

1.54e-0329592EFO_0010434
Diseaselow density lipoprotein cholesterol measurement, lipid measurement

GCKR PCSK9 TFR2

1.56e-03114593EFO_0004529, EFO_0004611
Diseasetotal cholesterol measurement, low density lipoprotein cholesterol measurement

GCKR PCSK9 TFR2

1.56e-03114593EFO_0004574, EFO_0004611
Diseaseneuroblastoma

ARHGEF40 TRIO DNAH5

1.64e-03116593EFO_0000621
Diseasepulmonary hypertension (is_implicated_in)

VWF VEGFB

1.65e-0330592DOID:6432 (is_implicated_in)
Diseasewaist circumference

TAOK2 TIAM1 SYT3 TRIO DNAH5

1.67e-03429595EFO_0004342
Diseaselevel of Sterol ester (27:1/20:4) in blood serum

AHNAK PCSK9

1.76e-0331592OBA_2045198
Diseaselow density lipoprotein cholesterol measurement, phospholipid measurement

GCKR PCSK9 TFR2

1.81e-03120593EFO_0004611, EFO_0004639
Diseasenephrolithiasis

DGKH GCKR

1.99e-0333592EFO_0004253

Protein segments in the cluster

PeptideGeneStartEntry
LNPNKPVVEWHREGI

ADPGK

446

Q9BRR6
RVAKPEELQWELGGH

ARHGEF40

651

Q8TER5
EGSPKLQHELIIPQW

ADAM19

36

Q9H013
IDVPDVGVQGPDWHL

AHNAK

3006

Q09666
APDVDVQGPDWHLKM

AHNAK

3136

Q09666
QVPEHWPQEGEIKIH

ABCC9

1301

O60706
HVEGGWPKDVNPLEL

DNAI2

76

Q9GZS0
LHWIPIPSNDEVVKQ

ASXL1

896

Q8IXJ9
DRWIKKIEEHAPGVP

RAB40A

106

Q8WXH6
DRWIKEIDEHAPGVP

RAB40B

106

Q12829
DRWIKEIDEHAPGVP

RAB40C

106

Q96S21
DRWIKKIEEHAPGVP

RAB40AL

106

P0C0E4
QVDQWKVPTGLEDPH

ARHGAP39

946

Q9C0H5
HILSPWGAEVKAEPV

PARP1

476

P09874
WGAEVKAEPVEVVAP

PARP1

481

P09874
QHWLEIGPPDLVERK

CFAP95

16

Q5VTT2
ISKNVEGIHLSWEPP

HCFC2

686

Q9Y5Z7
HLLHAVVPGPWQEDV

MST1L

41

Q2TV78
PDIKLHPWVTKNGEE

CAMKK1

401

Q8N5S9
LPPGEDLNDWVAVHV

MOB3A

51

Q96BX8
WEVEDLGTHKPPVLR

PCSK9

566

Q8NBP7
AQETHPLLGEWKIPE

PLXND1

1386

Q9Y4D7
DIVETPEGEKWPQLI

PCDH9

191

Q9HC56
PDHWEKAVITVQRPG

LAMB1

621

P07942
EAWVQPPGIIKIVHK

DGKH

926

Q86XP1
EKENLPVFPVWVVVG

MPZL1

156

O95297
SRKHLWPVVPDDVEQ

RICTOR

996

Q6R327
RFQHVIETPEPGKWE

GCKR

6

Q14397
PAGVDPIIWEQAKVD

NUP54

301

Q7Z3B4
KLPVWVVEDHQEVLP

C5orf22

16

Q49AR2
EVIKENIHHIEWAPP

AGBL2

186

Q5U5Z8
LHLTGKNWIEIPVPE

CNTN2

961

Q02246
KNWIEIPVPEDIGHA

CNTN2

966

Q02246
PHREADGIPGKVAWE

INSRR

811

P14616
ISFVEEDVHPKWIPG

AHCTF1

1231

Q8WYP5
DGKPLQPVVHIWDSE

EML3

331

Q32P44
HLLHAVVPGPWQEDV

MST1

36

P26927
KDLPVNDEHVTVPPW

CCNA2

76

P20248
KDWLVENAPGDEVPI

DSEL

156

Q8IZU8
LWGPQPVLVHVKDEN

CDH16

106

O75309
EEAGLINHPPWKLKV

DNAH5

2231

Q8TE73
PPGENIDDWIAVHVV

MOB3C

51

Q70IA8
NPRKPVEHWHQLVEE

SYT3

556

Q9BQG1
QLEQLPEHIKEPIWE

MRPS10

176

P82664
VDVHPDVIPVQLWGL

TDRD6

21

O60522
TKPHPAEGQWRAVDV

TAPBPL

21

Q9BX59
PNVPVVVRGWLHKQD

PLEKHA7

161

Q6IQ23
PSPQKHGSLVDEEVW

TAOK2

826

Q9UL54
PWEHPLVQEAGEGIL

WIZ

76

O95785
WDNIQELLGHPVEKP

PHAF1

351

Q9BSU1
QKHIEVWDPSPEEII

RNF17

876

Q9BXT8
PELHIFQPEWKIGNQ

ZNF321P

96

Q8N8H1
HQVPEKLIWGDQDPL

WDR88

76

Q6ZMY6
IDVPWNVVPEKAHLL

VWF

1741

P04275
WVENSIVQAVPEHPK

TIAM1

496

Q13009
GIPNIEDAENWHGKP

TKTL2

251

Q9H0I9
WHGKPVPKERADAIV

TKTL2

261

Q9H0I9
VLNVWGKVEADIPGH

MB

11

P02144
PDAPGHQRKVVSWID

VEGFB

26

P49765
KQGKEPWILEVEFPH

ZNF25

61

P17030
GHCIVKLIPWPLEEQ

WSB2

46

Q9NYS7
LDVKHQPSVPVGQLW

TUT7

541

Q5VYS8
PEGIPVAEVEWLKNE

UNC5C

191

O95185
LHWVDEAGKVGEQLP

TFR2

211

Q9UP52
QTVEVLERPHDKPDW

TRIO

1681

O75962
PNPIHIWDKVIVDGS

TNRC6B

181

Q9UPQ9