Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionNAD+-protein-serine ADP-ribosyltransferase activity

PARP2 PARP1

4.67e-0521372GO:0140805
GeneOntologyMolecularFunctionsulfonylurea receptor activity

ABCC9 ABCC8

4.67e-0521372GO:0008281
GeneOntologyMolecularFunctionNAD DNA ADP-ribosyltransferase activity

PARP2 PARP1

1.40e-0431372GO:0140294
GeneOntologyMolecularFunctionNAD+-protein-glutamate ADP-ribosyltransferase activity

PARP2 PARP1

2.78e-0441372GO:0140807
GeneOntologyMolecularFunctionABC-type transporter activity

ABCC9 ABCA8 ABCC8 ABCG2

3.54e-04491374GO:0140359
GeneOntologyMolecularFunctionNAD+-protein-aspartate ADP-ribosyltransferase activity

PARP2 PARP1

4.61e-0451372GO:0140806
GeneOntologyMolecularFunctionhistone H3K27me2/H3K27me3 demethylase activity

KDM6B UTY

4.61e-0451372GO:0071558
GeneOntologyMolecularFunctionATP-activated inward rectifier potassium channel activity

ABCC9 ABCC8

6.88e-0461372GO:0015272
GeneOntologyMolecularFunctionNAD+-protein poly-ADP-ribosyltransferase activity

PARP2 PARP1 PARP4

9.13e-04281373GO:0003950
GeneOntologyMolecularFunctionclathrin light chain binding

NSG2 NSG1

9.59e-0471372GO:0032051
GeneOntologyMolecularFunctionNAD+-protein ADP-ribosyltransferase activity

PARP2 PARP1 PARP4

1.12e-03301373GO:1990404
GeneOntologyCellularComponentpotassium ion-transporting ATPase complex

ABCC9 ABCC8

1.31e-0431392GO:0031004
GeneOntologyCellularComponenttrans-Golgi network

COG2 NBEA GPR108 NSG2 NSG1 FUT9 KIF13A RAB29 DOP1A

2.13e-043061399GO:0005802
GeneOntologyCellularComponentinward rectifying potassium channel

ABCC9 ABCC8

2.61e-0441392GO:0008282
GeneOntologyCellularComponenthistone locus body

ICE2 ICE1

2.61e-0441392GO:0035363
DomainPARP_ALPHA_HD

PARP2 PARP1 PARP4

1.60e-0641393PS51060
DomainPoly(ADP-ribose)pol_reg_dom

PARP2 PARP1 PARP4

1.60e-0641393IPR004102
Domain-

PARP2 PARP1 PARP4

1.60e-06413931.20.142.10
DomainDEP

GPR155 DVL1P1 DVL1 PLEK2

1.94e-05221394PF00610
DomainDEP

GPR155 DVL1P1 DVL1 PLEK2

1.94e-05221394PS50186
DomainDEP

GPR155 DVL1P1 DVL1 PLEK2

1.94e-05221394SM00049
DomainDEP_dom

GPR155 DVL1P1 DVL1 PLEK2

2.33e-05231394IPR000591
DomainSulphorea_rcpt

ABCC9 ABCC8

5.50e-0521392IPR000388
DomainDVL-1

DVL1P1 DVL1

5.50e-0521392IPR008340
DomainCalcyon

NSG2 NSG1

1.64e-0431392PF06387
DomainWGR

PARP2 PARP1

1.64e-0431392SM00773
DomainPARP_reg

PARP2 PARP1

1.64e-0431392PF02877
DomainWGR

PARP2 PARP1

1.64e-0431392PF05406
DomainORMDL

ORMDL3 ORMDL2

1.64e-0431392IPR007203
DomainORMDL

ORMDL3 ORMDL2

1.64e-0431392PF04061
DomainCalcyon_neuron-sp

NSG2 NSG1

1.64e-0431392IPR009431
DomainTFIID-31

TAF9B TAF9

1.64e-0431392IPR003162
DomainTFIID-31kDa

TAF9B TAF9

1.64e-0431392PF02291
Domain-

PARP2 PARP1

1.64e-04313922.20.140.10
DomainPoly(ADP-ribose)pol_cat_dom

PARP2 PARP1 PARP4

2.54e-04171393IPR012317
DomainPARP_CATALYTIC

PARP2 PARP1 PARP4

2.54e-04171393PS51059
DomainPARP

PARP2 PARP1 PARP4

2.54e-04171393PF00644
Domain-

PARP2 PARP1 PARP4

2.54e-041713933.90.228.10
DomainDishevelled

DVL1P1 DVL1

3.27e-0441392PF02377
DomainDNA_pol_B

POLD1 POLE

3.27e-0441392PF00136
DomainDNA-dir_DNA_pol_B

POLD1 POLE

3.27e-0441392IPR006172
DomainDishevelled_fam

DVL1P1 DVL1

3.27e-0441392IPR008339
DomainDNA-dir_DNA_pol_B_exonuc

POLD1 POLE

3.27e-0441392IPR006133
DomainDNA-dir_DNA_pol_B_multi_dom

POLD1 POLE

3.27e-0441392IPR006134
DomainDNA_pol_B_exo1

POLD1 POLE

3.27e-0441392PF03104
DomainDishevelled_protein_dom

DVL1P1 DVL1

3.27e-0441392IPR003351
DomainPOLBc

POLD1 POLE

3.27e-0441392SM00486
DomainABC_tran

ABCC9 ABCA8 ABCC8 ABCG2

4.43e-04481394PF00005
DomainABC_TRANSPORTER_2

ABCC9 ABCA8 ABCC8 ABCG2

4.43e-04481394PS50893
DomainABC_TRANSPORTER_1

ABCC9 ABCA8 ABCC8 ABCG2

4.80e-04491394PS00211
DomainABC_transporter-like

ABCC9 ABCA8 ABCC8 ABCG2

5.19e-04501394IPR003439
DomainAnaphylatoxin_comp_syst

C4A C4B

5.42e-0451392IPR018081
DomainAnaphylatoxn_comp_syst_dom

C4A C4B

5.42e-0451392IPR001840
DomainSushi

CSMD2 CR2 CSMD3 C4BPA

6.03e-04521394PF00084
DomainCCP

CSMD2 CR2 CSMD3 C4BPA

6.96e-04541394SM00032
DomainWGR_domain

PARP2 PARP1 PARP4

7.28e-04241393IPR008893
DomainSUSHI

CSMD2 CR2 CSMD3 C4BPA

7.99e-04561394PS50923
Domain-

TDRD15 SND1

8.09e-04613922.40.50.90
DomainStaphylococal_nuclease_OB-fold

TDRD15 SND1

8.09e-0461392IPR016071
DomainAminotrans_V_dom

KYNU MOCOS

8.09e-0461392IPR000192
DomainAminotran_5

KYNU MOCOS

8.09e-0461392PF00266
DomainSushi_SCR_CCP_dom

CSMD2 CR2 CSMD3 C4BPA

8.55e-04571394IPR000436
DomainANATO

C4A C4B

1.13e-0371392SM00104
DomainANAPHYLATOXIN_2

C4A C4B

1.13e-0371392PS01178
DomainANAPHYLATOXIN_1

C4A C4B

1.13e-0371392PS01177
DomainANATO

C4A C4B

1.13e-0371392PF01821
DomainDIX

DVL1P1 DVL1

1.13e-0371392PF00778
DomainDIX

DVL1P1 DVL1

1.13e-0371392IPR001158
DomainDIX

DVL1P1 DVL1

1.13e-0371392PS50841
DomainDAX

DVL1P1 DVL1

1.13e-0371392SM00021
DomainAnaphylatoxin/fibulin

C4A C4B

1.13e-0371392IPR000020
DomainCadherin_CS

DCHS2 PCDHGB6 PCDHGB1 FAT1 PCDH15

1.34e-031091395IPR020894
DomainMacrogloblnA2_thiol-ester-bond

C4A C4B

1.50e-0381392IPR019565
DomainThiol-ester_cl

C4A C4B

1.50e-0381392PF10569
DomainMacrogloblnA2_CS

C4A C4B

1.50e-0381392IPR019742
DomainCADHERIN_1

DCHS2 PCDHGB6 PCDHGB1 FAT1 PCDH15

1.57e-031131395PS00232
DomainCadherin

DCHS2 PCDHGB6 PCDHGB1 FAT1 PCDH15

1.57e-031131395PF00028
DomainCADHERIN_2

DCHS2 PCDHGB6 PCDHGB1 FAT1 PCDH15

1.63e-031141395PS50268
Domain-

DCHS2 PCDHGB6 PCDHGB1 FAT1 PCDH15

1.63e-0311413952.60.40.60
DomainCA

DCHS2 PCDHGB6 PCDHGB1 FAT1 PCDH15

1.69e-031151395SM00112
DomainCadherin-like

DCHS2 PCDHGB6 PCDHGB1 FAT1 PCDH15

1.76e-031161395IPR015919
DomainCadherin

DCHS2 PCDHGB6 PCDHGB1 FAT1 PCDH15

1.90e-031181395IPR002126
DomainA2M

C4A C4B

2.38e-03101392PF00207
DomainA2M_N_2

C4A C4B

2.38e-03101392IPR011625
DomainA2M_comp

C4A C4B

2.38e-03101392IPR011626
DomainA2M_recep

C4A C4B

2.38e-03101392PF07677
DomainA2M_comp

C4A C4B

2.38e-03101392PF07678
DomainA2M_N

C4A C4B

2.38e-03101392PF01835
DomainA2M_N

C4A C4B

2.38e-03101392IPR002890
DomainA-macroglobulin_rcpt-bd

C4A C4B

2.38e-03101392IPR009048
DomainALPHA_2_MACROGLOBULIN

C4A C4B

2.38e-03101392PS00477
DomainA2M_N_2

C4A C4B

2.38e-03101392PF07703
DomainMacroglobln_a2

C4A C4B

2.38e-03101392IPR001599
DomainFilamin

FLNC MYCBP2

2.89e-03111392PF00630
DomainFILAMIN_REPEAT

FLNC MYCBP2

2.89e-03111392PS50194
DomainDHR-1_domain

DOCK5 DOCK7

2.89e-03111392IPR027007
DomainDHR_2

DOCK5 DOCK7

2.89e-03111392PS51651
DomainDHR_1

DOCK5 DOCK7

2.89e-03111392PS51650
DomainDHR-2

DOCK5 DOCK7

2.89e-03111392PF06920
DomainFilamin/ABP280_rpt

FLNC MYCBP2

2.89e-03111392IPR001298
DomainFilamin/ABP280_repeat-like

FLNC MYCBP2

2.89e-03111392IPR017868
DomainDOCK

DOCK5 DOCK7

2.89e-03111392IPR026791
DomainHlyIII

PAQR8 PAQR5

2.89e-03111392PF03006
DomainDOCK_C

DOCK5 DOCK7

2.89e-03111392IPR010703
DomainDOCK-C2

DOCK5 DOCK7

2.89e-03111392PF14429
DomainDHR-2

DOCK5 DOCK7

2.89e-03111392IPR027357
DomainAdipoR/HlyIII-related

PAQR8 PAQR5

2.89e-03111392IPR004254
DomainRho_GTPase_activation_prot

STARD13 PLXNA3 ARHGAP5 SRGAP1

4.23e-03881394IPR008936
DomainTUDOR

TDRD15 SND1

4.72e-03141392PF00567
DomainMyosin_N

MYH2 MYH8

5.42e-03151392PF02736
DomainMyosin_N

MYH2 MYH8

5.42e-03151392IPR004009
DomainC345C

C4A C4B

6.95e-03171392SM00643
PathwayKEGG_BASE_EXCISION_REPAIR

POLD1 POLE PARP2 PARP1 PARP4

6.80e-06351095M5500
PathwayREACTOME_RESOLUTION_OF_AP_SITES_VIA_THE_MULTIPLE_NUCLEOTIDE_PATCH_REPLACEMENT_PATHWAY

POLD1 POLE PARP2 PARP1

3.77e-05251094M541
PathwayREACTOME_RESOLUTION_OF_AP_SITES_VIA_THE_MULTIPLE_NUCLEOTIDE_PATCH_REPLACEMENT_PATHWAY

POLD1 POLE PARP2 PARP1

4.43e-05261094MM14481
PathwayWP_BASE_EXCISION_REPAIR

POLD1 POLE PARP2 PARP1

9.06e-05311094M39861
PathwayREACTOME_HDR_THROUGH_MMEJ_ALT_NHEJ

PARP2 PARP1 BRCA2

9.40e-05121093M27569
PathwayREACTOME_HDR_THROUGH_MMEJ_ALT_NHEJ

PARP2 PARP1 BRCA2

9.40e-05121093MM15282
PathwayKEGG_COMPLEMENT_AND_COAGULATION_CASCADES

CR2 F5 C4A C4B C4BPA

1.91e-04691095M16894
PathwayREACTOME_RESOLUTION_OF_ABASIC_SITES_AP_SITES

POLD1 POLE PARP2 PARP1

2.04e-04381094M27701
PathwayREACTOME_RESOLUTION_OF_ABASIC_SITES_AP_SITES

POLD1 POLE PARP2 PARP1

2.26e-04391094MM17222
PathwayREACTOME_DUAL_INCISION_IN_GG_NER

POLD1 POLE PARP2 PARP1

2.75e-04411094M27595
PathwayREACTOME_DUAL_INCISION_IN_GG_NER

POLD1 POLE PARP2 PARP1

3.02e-04421094MM15306
PathwayKEGG_ABC_TRANSPORTERS

ABCC9 ABCA8 ABCC8 ABCG2

3.62e-04441094M11911
Pubmed

Transmission of antibody-induced arthritis is independent of complement component 4 (C4) and the complement receptors 1 and 2 (CD21/35).

CR2 C4A C4B

6.52e-083141311857338
Pubmed

Complement C4 inhibits systemic autoimmunity through a mechanism independent of complement receptors CR1 and CR2.

CR2 C4A C4B

2.60e-074141311067882
Pubmed

Antigen localization within the splenic marginal zone restores humoral immune response and IgG class switch in complement C4-deficient mice.

CR2 C4A C4B

2.60e-074141315477230
Pubmed

Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.

MIA3 POLE SIN3A DICER1 DOCK5 PARP4 TMEM62 TBK1 DOCK7 C4A C4B HSD17B4 KYNU MOCOS

4.52e-076501411438777146
Pubmed

Role of complement receptors 1 and 2 (CD35 and CD21), C3, C4, and C5 in survival by mice of Staphylococcus aureus bacteremia.

CR2 C4A C4B

6.48e-075141315192652
Pubmed

Protective T cell-independent antiviral antibody responses are dependent on complement.

CR2 C4A C4B

6.48e-075141310523614
Pubmed

Stromal complement receptor CD21/35 facilitates lymphoid prion colonization and pathogenesis.

CR2 C4A C4B

6.48e-075141317947689
Pubmed

Poly(ADP-ribose) polymerases PARP1 and PARP2 modulate topoisomerase II beta (TOP2B) function during chromatin condensation in mouse spermiogenesis.

PARP2 PARP1 TOP2B

6.48e-075141321228215
Pubmed

CD21/35 promotes protective immunity to Streptococcus pneumoniae through a complement-independent but CD19-dependent pathway that regulates PD-1 expression.

CR2 C4A C4B

1.29e-066141319710450
Pubmed

Constitutive expression of TNF-alpha and -beta genes in mouse embryo: roles of cytokines as regulator and effector on development.

CR2 C4A C4B IL1A

1.47e-062114148138038
Pubmed

LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy.

COPA ICE1 DICER1 DOCK5 PARP4 PI4KA DOCK7 TOP2B

1.84e-06202141833005030
Pubmed

Antibodies and complement are key drivers of thrombosis.

CR2 ITGAX C4A C4B

2.16e-0623141439226900
Pubmed

Identification of 18 mouse ABC genes and characterization of the ABC superfamily in Mus musculus.

ABCC9 ABCA8 ABCC8 ABCG2

2.16e-0623141410708515
Pubmed

Mapping specific protein-protein interactions within the core component of the breast cell DNA synthesome.

POLD1 POLE PARP1

2.26e-06714139563011
Pubmed

Divergent immunoglobulin g subclass activity through selective Fc receptor binding.

CR2 C4A C4B

3.60e-068141316322460
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

COG2 DCHS2 WASHC4 COPA MYCBP2 USP9X ENC1 NBEA KDM6B ZNF181 TXNDC11 ARHGAP5 PARP1 RORB CTNND2 ZNF606 HSD17B4 AGTPBP1

4.87e-0612851411835914814
Pubmed

Constitutive and interleukin-1-inducible phosphorylation of p65 NF-{kappa}B at serine 536 is mediated by multiple protein kinases including I{kappa}B kinase (IKK)-{alpha}, IKK{beta}, IKK{epsilon}, TRAF family member-associated (TANK)-binding kinase 1 (TBK1), and an unknown kinase and couples p65 to TATA-binding protein-associated factor II31-mediated interleukin-8 transcription.

TBK1 TAF9 IL1A

5.38e-069141315489227
Pubmed

Small molecule inhibitors uncover synthetic genetic interactions of human flap endonuclease 1 (FEN1) with DNA damage response genes.

PARP2 PARP1 BRCA2

5.38e-069141328628639
Pubmed

Comparative interactome analysis of α-arrestin families in human and Drosophila.

FLNC COPA USP9X POLD1 PI4KA DOCK7 CPSF1 WDR82 ABCG2

5.71e-06313141938270169
Pubmed

CLEC16A interacts with retromer and TRIM27, and its loss impairs endosomal trafficking and neurodevelopment.

COG2 MYCBP2 POLD1 POLE HM13 NDUFS8 PARP4 BRCA2 PI4KA TBK1 CPSF1 TAF9

7.28e-066061411236538041
Pubmed

E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.

LAMB4 MUC19 NBEA ICE1 CSMD2 NUP205 DOCK5 ARHGAP5 PARP4 PI4KA TBK1 CCDC87 CPSF1

1.02e-057361411329676528
Pubmed

Genetic variation in the base excision repair pathway and bladder cancer risk.

POLD1 PARP1 PARP4

1.40e-0512141317203305
Pubmed

Copy number analysis of complement C4A, C4B and C4A silencing mutation by real-time quantitative polymerase chain reaction.

C4A C4B

1.63e-052141222737222
Pubmed

Deficiency of C4 from donor or recipient mouse fails to prevent renal allograft rejection.

C4A C4B

1.63e-052141216565498
Pubmed

Complete deficiencies of complement C4A and C4B including 2-bp insertion in codon 1213 are genetic risk factors of systemic lupus erythematosus in Thai populations.

C4A C4B

1.63e-052141215998580
Pubmed

High-throughput analysis of the C4 polymorphism by a combination of MLPA and isotype-specific ELISA's.

C4A C4B

1.63e-052141219062096
Pubmed

Activation of innate and humoral immunity in the peripheral nervous system of ALS transgenic mice.

C4A C4B

1.63e-052141219933335
Pubmed

Structural basis for the C4d.1/C4d.2 serologic allotypes of murine complement component C4.

C4A C4B

1.63e-05214122459207
Pubmed

Antigen-induced B cell apoptosis is independent of complement C4.

C4A C4B

1.63e-052141217645767
Pubmed

Combined mismatch repair and POLE/POLD1 defects explain unresolved suspected Lynch syndrome cancers.

POLD1 POLE

1.63e-052141226648449
Pubmed

Anti-DNA autoreactivity in C4-deficient mice.

C4A C4B

1.63e-052141212207352
Pubmed

Poly(ADP-Ribose) Polymerases: New Players in the Pathogenesis of Exocrine Pancreatic Diseases.

PARP2 PARP1

1.63e-052141226687988
Pubmed

Complement C4A and C4B Gene Copy Number Study in Alzheimer's Disease Patients.

C4A C4B

1.63e-052141227758680
Pubmed

Genetically determined partial complement C4 deficiency states are not independent risk factors for SLE in UK and Spanish populations.

C4A C4B

1.63e-052141222387014
Pubmed

Hypoxia-inducible factor-2alpha transactivates Abcg2 and promotes cytoprotection in cardiac side population cells.

ABCG2 EPAS1

1.63e-052141218356544
Pubmed

Polymerase proofreading-associated polyposis: a new, dominantly inherited syndrome of hereditary colorectal cancer predisposition.

POLD1 POLE

1.63e-052141224509466
Pubmed

Increased somatic mutation burdens in normal human cells due to defective DNA polymerases.

POLD1 POLE

1.63e-052141234594041
Pubmed

Molecular determinants of ATP-sensitive potassium channel MgATPase activity: diabetes risk variants and diazoxide sensitivity.

ABCC9 ABCC8

1.63e-052141226181369
Pubmed

Complement C4 maintains peripheral B-cell tolerance in a myeloid cell dependent manner.

C4A C4B

1.63e-052141223749435
Pubmed

Copy number variations of complement component C4 are associated with Behçet's disease but not with ankylosing spondylitis associated with acute anterior uveitis.

C4A C4B

1.63e-052141223918728
Pubmed

Molecular genetics of androgen-dependent and -independent expression of mouse sex-limited protein.

C4A C4B

1.63e-05214123037333
Pubmed

Long patch base excision repair with purified human proteins. DNA ligase I as patch size mediator for DNA polymerases delta and epsilon.

POLD1 POLE

1.63e-052141210559260
Pubmed

Evidence of a role for C4 in modulating interstitial inflammation in experimental glomerulonephritis.

C4A C4B

1.63e-052141211726230
Pubmed

Quantitative variations in the expression of the mouse serum antigen Ss and its sex-limited allotype Slp.

C4A C4B

1.63e-05214124216347
Pubmed

Sequence determination of the thiolester site of the fourth component of human complement.

C4A C4B

1.63e-05214126950384
Pubmed

ORMDL2 Deficiency Potentiates the ORMDL3-Dependent Changes in Mast Cell Signaling.

ORMDL3 ORMDL2

1.63e-052141233643282
Pubmed

Visual demonstration of the organization of the human complement C4 and 21-hydroxylase genes by high-resolution fluorescence in situ hybridization.

C4A C4B

1.63e-05214128660986
Pubmed

Tissue-specific RNA processing for the complement C4 gene transcript in the H-2k mouse strain.

C4A C4B

1.63e-05214128428773
Pubmed

Identification of a novel gene (ADPRTL1) encoding a potential Poly(ADP-ribosyl)transferase protein.

PARP2 PARP4

1.63e-052141210644454
Pubmed

Involvement of HIV-1 protease in virus-induced cell killing.

PARP1 PARP4

1.63e-052141215781132
Pubmed

Complement C4 deficiency--a plausible risk factor for non-tuberculous mycobacteria (NTM) infection in apparently immunocompetent patients.

C4A C4B

1.63e-052141224638111
Pubmed

Transcriptional repression of C4 complement by hepatitis C virus proteins.

C4A C4B

1.63e-052141221345967
Pubmed

Role of POLE and POLD1 in familial cancer.

POLD1 POLE

1.63e-052141232792570
Pubmed

Single-molecule force spectroscopy reveals binding and bridging dynamics of PARP1 and PARP2 at DNA double-strand breaks.

PARP2 PARP1

1.63e-052141237216533
Pubmed

Poly(ADP-ribose) reactivates stalled DNA topoisomerase I and Induces DNA strand break resealing.

PARP2 PARP1

1.63e-052141214699148
Pubmed

Restriction fragment analysis of H-2 recombinant mouse strains with crossovers between E alpha and C4 genes.

C4A C4B

1.63e-05214122572548
Pubmed

The complement component C4 of mammals.

C4A C4B

1.63e-05214122302180
Pubmed

Human mismatch repair system balances mutation rates between strands by removing more mismatches from the lagging strand.

POLD1 POLE

1.63e-052141228512192
Pubmed

MicroRNA expression and protein acetylation pattern in respiratory and limb muscles of Parp-1(-/-) and Parp-2(-/-) mice with lung cancer cachexia.

PARP2 PARP1

1.63e-052141226432600
Pubmed

Functional interaction between PARP-1 and PARP-2 in chromosome stability and embryonic development in mouse.

PARP2 PARP1

1.63e-052141212727891
Pubmed

Gene CNVs and protein levels of complement C4A and C4B as novel biomarkers for partial disease remissions in new-onset type 1 diabetes patients.

C4A C4B

1.63e-052141222151770
Pubmed

C4d-positive chronic rejection: a frequent entity with a poor outcome.

C4A C4B

1.63e-052141218091514
Pubmed

Comprehensive approach to study complement C4 in systemic lupus erythematosus: Gene polymorphisms, protein levels and functional activity.

C4A C4B

1.63e-052141229080553
Pubmed

Genes for murine fourth complement component (C4) and sex-limited protein (Slp) identified by hybridization to C4- and Slp-specific cDNA.

C4A C4B

1.63e-05214126589636
Pubmed

C4 Deficiency is a predisposing factor for Streptococcus pneumoniae-induced autoantibody production.

C4A C4B

1.63e-052141225339671
Pubmed

Feedback-regulated poly(ADP-ribosyl)ation by PARP-1 is required for rapid response to DNA damage in living cells.

PARP2 PARP1

1.63e-052141217982172
Pubmed

A study of association of the complement C4 mutations with systemic lupus erythematosus in the Malaysian population.

C4A C4B

1.63e-052141217728371
Pubmed

Germline and somatic polymerase ε and δ mutations define a new class of hypermutated colorectal and endometrial cancers.

POLD1 POLE

1.63e-052141223447401
Pubmed

Poly(ADP-ribose) polymerases covalently modify strand break termini in DNA fragments in vitro.

PARP2 PARP1

1.63e-052141227471034
Pubmed

PARP2 deficiency affects invariant-NKT-cell maturation and protects mice from concanavalin A-induced liver injury.

PARP2 PARP1

1.63e-052141228751426
Pubmed

Structure and organization of the C4 genes.

C4A C4B

1.63e-05214126149580
Pubmed

Sequence heterogeneity of murine complementary DNA clones related to the C4 and C4-Slp isoforms of the fourth complement component.

C4A C4B

1.63e-05214126149581
Pubmed

The follicular dendritic cell restricted epitope, FDC-M2, is complement C4; localization of immune complexes in mouse tissues.

C4A C4B

1.63e-052141212115608
Pubmed

Biochemistry and biology of anaphylatoxins.

C4A C4B

1.63e-05214123542363
Pubmed

C4 from C4-high and C4-low mouse strains have identical sequences in the region corresponding to the isotype-specific segment of human C4.

C4A C4B

1.63e-05214122387317
Pubmed

Role of PARP-1 and PARP-2 in the expression of apoptosis-regulating genes in HeLa cells.

PARP2 PARP1

1.63e-052141218587655
Pubmed

In vivo functional analysis of the histone 3-like TAF9 and a TAF9-related factor, TAF9L.

TAF9B TAF9

1.63e-052141212837753
Pubmed

Tumor-Infiltrating Lymphocytes, Tumor Mutational Burden, and Genetic Alterations in Microsatellite Unstable, Microsatellite Stable, or Mutant POLE/POLD1 Colon Cancer.

POLD1 POLE

1.63e-052141234250404
Pubmed

Identification of the size and antigenic determinants of the human C4 gene by a polymerase chain-reaction-based amplification method.

C4A C4B

1.63e-052141216908004
Pubmed

Structural studies on the murine fourth component of complement (C4). IV. Demonstration that C4 and Slp are encoded by separate loci.

C4A C4B

1.63e-05214127365238
Pubmed

Interaction between the labile binding sites of the fourth (C4) and fifth (C5) human complement proteins and erythrocyte cell membranes.

C4A C4B

1.63e-05214127391573
Pubmed

Peritubular capillary C4d deposition in lupus nephritis different from antibody-mediated renal rejection.

C4A C4B

1.63e-052141217971360
Pubmed

Clinical features of patients with homozygous complement C4A or C4B deficiency.

C4A C4B

1.63e-052141229928053
Pubmed

Analysis of C4 and the C4 binding protein in the MRL/lpr mouse.

C4A C4B

1.63e-052141217971229
Pubmed

Genetic deficiency of C4 presenting with recurrent infections and a SLE-like disease. Genetic and immunologic studies.

C4A C4B

1.63e-05214126881182
Pubmed

Dicer-mediated upregulation of BCRP confers tamoxifen resistance in human breast cancer cells.

DICER1 ABCG2

1.63e-052141221878538
Pubmed

Genetic ablation of PARP-1 protects against oxazolone-induced contact hypersensitivity by modulating oxidative stress.

PARP2 PARP1

1.63e-052141220613774
Pubmed

Partial C4 deficiency in juvenile idiopathic arthritis patients.

C4A C4B

1.63e-052141217921792
Pubmed

Complement activation and complement receptors on follicular dendritic cells are critical for the function of a targeted adjuvant.

C4A C4B

1.63e-052141221880985
Pubmed

Amino acid sequence around the thiol and reactive acyl groups of human complement component C4.

C4A C4B

1.63e-05214126978711
Pubmed

Plasma Complement 3 and Complement 4 Are Promising Biomarkers for Distinguishing NMOSD From MOGAD and Are Associated With the Blood-Brain-Barrier Disruption in NMOSD.

C4A C4B

1.63e-052141235898513
Pubmed

Borrelia burgdorferi outer surface protein C (OspC) binds complement component C4b and confers bloodstream survival.

C4A C4B

1.63e-052141228873507
Pubmed

POLE/POLD1 mutation in non-exonuclease domain matters for predicting efficacy of immune-checkpoint-inhibitor therapy.

POLD1 POLE

1.63e-052141234586735
Pubmed

Mutation spectrum of POLE and POLD1 mutations in South East Asian women presenting with grade 3 endometrioid endometrial carcinomas.

POLD1 POLE

1.63e-052141226748215
Pubmed

Studies on the murine Ss protein: demonstration that the Ss protein is functionally the fourth component of complement.

C4A C4B

1.63e-0521412276882
Pubmed

Amino acid sequence of a polymorphic segment from fragment C4d of human complement component C4.

C4A C4B

1.63e-05214126832377
Pubmed

Reduced tumor burden through increased oxidative stress in lung adenocarcinoma cells of PARP-1 and PARP-2 knockout mice.

PARP2 PARP1

1.63e-052141226700152
Pubmed

PARP-2 deficiency affects the survival of CD4+CD8+ double-positive thymocytes.

PARP2 PARP1

1.63e-052141216946705
Pubmed

Recombination of two homologous MHC class III genes of the mouse (C4 and Slp) that accounts for the loss of testosterone dependence of sex-limited protein expression.

C4A C4B

1.63e-05214123794341
Pubmed

Human homologue sequences to the Drosophila dishevelled segment-polarity gene are deleted in the DiGeorge syndrome.

DVL1P1 DVL1

1.63e-05214128644734
InteractionTAF13 interactions

POLD1 PARP1 TAF9B CPSF1 TAF9

5.46e-06381365int:TAF13
InteractionLRRC31 interactions

COPA ICE1 DICER1 DOCK5 PARP1 PARP4 PI4KA DOCK7 TOP2B

1.07e-052051369int:LRRC31
InteractionSORT1 interactions

MIA3 COPA ICE2 DICER1 TXNDC11 UTP15 PI4KA CSPG4 HSD17B4

1.21e-052081369int:SORT1
GeneFamilyComplement system|Sushi domain containing

CR2 ITGAX C4A C4B

3.70e-0536954492
GeneFamilyCadherin related

DCHS2 FAT1 PCDH15

9.06e-051795324
GeneFamilyZinc fingers|Zinc fingers PARP-type|Poly(ADP-ribose) polymerases

PARP2 PARP1 PARP4

9.06e-0517953684
GeneFamilyHyalectan proteoglycans|V-set domain containing|Sushi domain containing|C-type lectin domain containing

CSMD2 CR2 CSMD3 C4BPA

2.28e-04579541179
GeneFamilyGlycosyltransferase family 6|Blood group antigens

C4A C4B ABCG2

9.59e-0437953454
GeneFamilyC3 and PZP like, alpha-2-macroglobulin domain containing

C4A C4B

9.60e-0499521234
GeneFamilyProgestin and adipoQ receptor family

PAQR8 PAQR5

1.46e-0311952930
GeneFamilyATP binding cassette subfamily C

ABCC9 ABCC8

2.05e-0313952807
GeneFamilyRho GTPase activating proteins|BCH domain containing

STARD13 ARHGAP5 SRGAP1

2.30e-0350953721
GeneFamilyMyosin heavy chains

MYH2 MYH8

2.74e-03159521098
GeneFamilyProtein tyrosine phosphatases, receptor type

PTPRG PTPRJ

5.38e-0321952813
GeneFamilyDNA polymerases

POLD1 POLE

6.43e-0323952535
GeneFamilyPHD finger proteins|Lysine demethylases

KDM6B UTY

6.99e-0324952485
CoexpressionMANNO_MIDBRAIN_NEUROTYPES_HGABA

GPR155 PLXNA3 MIA3 MYCBP2 ENC1 PAQR8 MUC19 NBEA GRIK2 SIN3A CSMD2 CSMD3 DICER1 NSG2 CSRNP3 SV2B SRGAP1 NSG1 FUT9 CTNND2 KIF13A ZMAT1 HYDIN AGTPBP1 DOP1A

8.01e-10110613925M39071
CoexpressionMANNO_MIDBRAIN_NEUROTYPES_HNBGABA

GPR155 MYCBP2 ENC1 PAQR8 MUC19 NBEA GRIK2 CSMD2 CSMD3 DICER1 NSG2 CSRNP3 SV2B NSG1 DOP1A

5.20e-0670313915M39070
CoexpressionAtlaskidney_adult_Podocyte_MafB_top-relative-expression-ranked_500

NEBL SGK3 DOCK5 PLEKHG1 ARHGAP5 PARP4 FAT1 CLIC5 TAF9B PTPRJ SRGAP1 PLEKHH2

3.24e-0544513712gudmap_kidney_adult_Podocyte_MafB_500
CoexpressionAtlaskidney_adult_RenCorpuscGlomer_k-means-cluster#3_top-relative-expression-ranked_500

NEBL DOCK5 PLEKHG1 CLIC5 PTPRJ SRGAP1 PLEKHH2

3.68e-051411377gudmap_kidney_adult_RenCorpuscGlomer_k3_500
ToppCellfacs-Lung-24m-Endothelial-capillary_endothelial-capillary_endothelial_cell-capillary_type_1_endothelial_cell|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

MYH2 HECW1 POLE CSMD3 F5 PKHD1L1 PCDH15 FUT9 HYDIN

2.38e-091621409bf886e22ff2a20353499004b53f25fb9e6574896
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-OPC-OPC-G|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

HECW1 CSMD2 CSMD3 ABCC8 CSPG4 PCDH15 PLEKHH2 KIF13A HYDIN

1.44e-08199140919a97e27a4758e794ce7246d295e112b47931a48
ToppCellfacs-Lung-Endomucin-24m-Endothelial-Capillary_Type_1_Cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MYH2 MYH8 HECW1 POLE CSMD3 PCDH15 FUT9 HYDIN

2.00e-08145140896712c68ab759d7ade0d912581a1a7c25dc6def8
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic-precursor_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MYH8 MUC19 GRIK2 PKHD1L1 ADCY8 PTPRG PLEKHH2 HYDIN

4.30e-081601408c381ec6be8cf887861cc18f831a20db42f953fe1
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic-pre_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MYH8 MUC19 GRIK2 PKHD1L1 ADCY8 PTPRG PLEKHH2 HYDIN

4.30e-08160140825c8f3d2a6d14ff0ca0b965fce89d3ff22f40585
ToppCellkidney_cells-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_2|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

MYH8 ENC1 SLC3A1 PARP4 FAT1 FUT9 PLEKHH2 HYDIN

1.83e-071931408ffa1932da2979d7b63dbac32eb5788346a3f5b2a
ToppCellMacroglial-Polydendrocytes-PDGFRA-|Macroglial / cells hierarchy compared to all cells using T-Statistic

HECW1 GRIK2 CSMD2 CSMD3 CSRNP3 CSPG4 PCDH15 PLEKHH2

2.40e-072001408f17b5a54e8f9eba9dcd0808ba4e8d275ac41bce2
ToppCellMacroglial-Polydendrocytes-PDGFRA--|Macroglial / cells hierarchy compared to all cells using T-Statistic

HECW1 GRIK2 CSMD2 CSMD3 CSRNP3 CSPG4 PCDH15 PLEKHH2

2.40e-072001408cc3409518f8b436ea92deb955e81114b3f410ff7
ToppCellMacroglial-Polydendrocytes-PDGFRA|Macroglial / cells hierarchy compared to all cells using T-Statistic

HECW1 GRIK2 CSMD2 CSMD3 CSRNP3 CSPG4 PCDH15 PLEKHH2

2.40e-072001408c24a3099e3d96d8b72f6d05286bb355d661a0377
ToppCellMacroglial-Polydendrocytes-PDGFRA---|Macroglial / cells hierarchy compared to all cells using T-Statistic

HECW1 GRIK2 CSMD2 CSMD3 CSRNP3 CSPG4 PCDH15 PLEKHH2

2.40e-0720014084fc3de4bff7ed2bf40b38462c4b4e9b87af6a4ca
ToppCellMacroglial-Polydendrocytes-PDGFRA----L1-6|Macroglial / cells hierarchy compared to all cells using T-Statistic

HECW1 GRIK2 CSMD2 CSMD3 CSRNP3 CSPG4 PCDH15 PLEKHH2

2.40e-072001408310cd53db1c137f6af74e6ae682221d7ac27310c
ToppCellMacroglial-Polydendrocytes|Macroglial / cells hierarchy compared to all cells using T-Statistic

HECW1 GRIK2 CSMD2 CSMD3 CSRNP3 CSPG4 PCDH15 PLEKHH2

2.40e-072001408961858738ce35db8760c8c2e136f8369bc444ccf
ToppCellCV-Mild-7|CV / Virus stimulation, Condition and Cluster

WASHC4 ICE2 NUP205 ZNF606 HSD17B4 DOP1A ANKS1A

1.14e-06170140725ebde7d2f8ae1afdfaf5876284ff20bb179eb10
ToppCellCOVID-19-Heart-Neuronal|Heart / Disease (COVID-19 only), tissue and cell type

STARD13 GPR155 TRABD2B GRIK2 DOCK5 PTPRJ CTNND2

1.29e-0617314076fb5f9e6536a5d57fd8e6657b494047a2d0bc9c7
ToppCellSmart-seq2-blood_(Smart-seq2)-myeloid-myeloid_monocytic-classical_monocyte|blood_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

LAMB4 MUC19 CNTLN CSMD3 SRGAP1 RORB AGTPBP1

2.08e-06186140723b8d51d20b05795a73892d3e20e0f9b6a207820
ToppCellcellseq-Mesenchymal-Fibroblastic-Fibroblastic_1-Mesothelial|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

FLNC EPGN PKHD1L1 ABCA8 TINAG C4A C4B

2.08e-0618614077812ed80d2378aca9957ef22fc3c8fb7fb58434b
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

HECW1 NEBL CSMD2 NSG2 SV2B RORB PLEKHH2

2.85e-061951407787e95fb59c40bba784544b662fac37606ae1427
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

TRABD2B NEBL PAQR5 SLC3A1 FAT1 PTPRJ HYDIN

2.95e-0619614076ce74aa3f0ce3ca284b67e5a4660ffd2cc9611e0
ToppCellBiopsy_IPF-Mesenchymal-Mesothelial_cells|Biopsy_IPF / Sample group, Lineage and Cell type

FLNC EPGN PKHD1L1 ABCA8 NSG1 C4A C4B

3.37e-062001407553386523fd8f8f36617a0d81032224b7ddce442
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

NEBL ADCY8 PARP4 FUT9 PLEKHH2 HYDIN

4.79e-0613714060aa4e14b32da0cda677cc0ed6ae470f6ecd77bea
ToppCellfacs-Marrow-KLS-18m-Myeloid-CD4+_macrophage|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GPR155 TRABD2B PAQR5 ITGAX CTNND2 KYNU

1.05e-0515714065d08ff0ba9d3df9cc30f13cab2d2b395ea6f3446
ToppCellfacs-Marrow-KLS-18m-Myeloid-macrophage|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GPR155 TRABD2B PAQR5 ITGAX CTNND2 KYNU

1.05e-051571406ad9c9b7dfeee3ae46e7e593c51a0407df12195b4
ToppCellPND10-Immune-Immune_Myeloid-Monocytic-Macrophage-AM-AM_mature|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ITGAX F5 ACOD1 FUT9 C4B IL1A

1.09e-051581406bdfa3aa1ffc025d846f14ccb3ca84d889916021f
ToppCellPND10-Immune-Immune_Myeloid-Monocytic-Macrophage-AM|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ITGAX F5 ACOD1 FUT9 C4B IL1A

1.25e-05162140616d625ac6702f79a83af444d2b3bf6759fd17cf6
ToppCellLV-16._Neuronal|World / Chamber and Cluster_Paper

GPR155 TRABD2B GRIK2 ABCA8 DOCK5 PTPRJ

1.39e-0516514066ed52cb756d21addf46c7f6c457458b01339fe04
ToppCellCOVID-19-Heart-Neuronal|COVID-19 / Disease (COVID-19 only), tissue and cell type

STARD13 GPR155 GRIK2 ABCA8 DOCK5 CTNND2

1.54e-05168140688c2c574f428c2502b5fe099bd73b0758f668ef6
ToppCellfacs-Diaphragm-Limb_Muscle-24m|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CSMD3 PKHD1L1 CSRNP3 PCDH15 C4B HYDIN

1.59e-05169140612bdc709bc000d7f9061ecd9fbd57233eaacb7e2
ToppCelldroplet-Fat-Scat-21m-Endothelial-nan|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NEBL PLEKHG1 CLIC5 BRCA2 ABCG2 EPAS1

1.82e-051731406f13124b4cf2ac1dc2895f90f5487d6ac681b0ba4
ToppCellCV-Mild-7|Mild / Virus stimulation, Condition and Cluster

WASHC4 ICE2 NUP205 PLEKHG1 DOP1A ANKS1A

1.82e-051731406c9bbca9313a0fdf146c8c995624b94b937e818d8
ToppCellfacs-Diaphragm-Limb_Muscle-24m-Mesenchymal|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FLNC CSMD3 PKHD1L1 PCDH15 C4B HYDIN

1.82e-05173140666f37c1437705734b20601656fa4aa1d92ca30be
ToppCellfacs-Diaphragm-Limb_Muscle-24m-Mesenchymal-nan|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FLNC CSMD3 PKHD1L1 PCDH15 C4B HYDIN

1.82e-051731406649b08a409095592cccf31883be69c754411280d
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

NEBL PARP4 FAT1 FUT9 PLEKHH2 HYDIN

2.00e-051761406327a3e81b724252e36d786de92a3ffd721ea6d7b
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

NEBL GRIK2 F5 DOCK5 CLIC5 SRGAP1

2.07e-0517714064d2cdb57b427a42085c5f9affa0967b15e84dec3
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

NEBL GRIK2 F5 DOCK5 CLIC5 SRGAP1

2.13e-051781406edc7143dc9959d36057cb9471681a23afcbc8cce
ToppCelldroplet-Marrow-nan-24m-Lymphocytic-precursor_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PAQR5 ITGAX STAT2 ARHGAP5 CTNND2 KYNU

2.27e-05180140664f01494a4052186773720e10b4e7c724ff94547
ToppCellRA-16._Neuronal|World / Chamber and Cluster_Paper

GPR155 TRABD2B PAQR8 GRIK2 DOCK5 PTPRJ

2.34e-0518114067d22a43f887e0747f0cb87ba364ff27905ee6eec
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_2|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

NEBL PARP4 FAT1 FUT9 PLEKHH2 HYDIN

2.42e-0518214065e1b316599436740f1b30875f0ebd33c3edfb2b6
ToppCellkidney_cells-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

DCHS2 MYH8 MUC19 ADCY8 SLC3A1 TINAG

2.49e-051831406d73cac83cde82665f110baad7cf28db75f9ffe52
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

NEBL GRIK2 F5 DOCK5 CLIC5 SRGAP1

2.49e-051831406848fc6dd129150897ee339343e83c645b6e779eb
ToppCellB_cells-ISG-high_B_cells|World / Immune cells in Kidney/Urine in Lupus Nephritis

CR2 STAT2 PLEKHG1 BRCA2 BTK DOP1A

2.49e-051831406dc2b00e920efa1dcc2a6265cd1024e3249c9974f
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

NEBL GRIK2 F5 DOCK5 CLIC5 SRGAP1

2.49e-051831406eb559ae3ae252d9365c24ef557dd49b78ed6d898
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

NEBL GRIK2 F5 DOCK5 CLIC5 SRGAP1

2.49e-0518314067c4b775f351794a3de06bd503eecbc8ae8577c44
ToppCellAT1-AT2_cells-Donor_02|World / lung cells shred on cell class, cell subclass, sample id

STARD13 NEBL ABCA8 CLIC5 CTNND2 PLEKHH2

2.49e-0518314066821dca076318115d360ff426eb1218cfe104063
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HECW1 CSMD3 PKHD1L1 FAT1 PCDH15 HYDIN

2.57e-0518414062cbed6462fea2622871bb7e49b0df3d984239281
ToppCellSmart-seq2-tissue-resident_(Smart-seq2)-myeloid-myeloid_granulocytic-neutrophil|tissue-resident_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

MUC19 CSMD3 ITGAX F5 C4BPA CTNND2

2.57e-0518414067ecdf2645e9378cf2f5ce4557f2cf100e6f184ba
ToppCellTCGA-Pancreas-Primary_Tumor-Pancreatic_Adenocarcinoma-Ductal_Adenocarcinoma-4|TCGA-Pancreas / Sample_Type by Project: Shred V9

MYCBP2 ABCC9 ABCA8 PTPRG CSRNP3 RORB

2.57e-05184140667164bb6bcae7322cb89b585c7aa10bce35b0ecd
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HECW1 CSMD3 PKHD1L1 FAT1 PCDH15 HYDIN

2.57e-051841406ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HECW1 CSMD3 PKHD1L1 FAT1 PCDH15 HYDIN

2.57e-0518414062b19a8c5f823e00812908b23e66bb4e563278aff
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Renal_corpuscle_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

NEBL GRIK2 F5 DOCK5 CLIC5 PLEKHH2

2.57e-0518414067294b379ce4cb8fa75e432559082f93cd106aaf5
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

NEBL GRIK2 F5 DOCK5 CLIC5 SRGAP1

2.65e-0518514069197f074e769d54031ec41abfc65fcc0c6552c7e
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

NEBL GRIK2 F5 DOCK5 CLIC5 SRGAP1

2.65e-051851406ce7d62394b09c26ca65b8cdb280afec5e25bbb62
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

NEBL GRIK2 F5 DOCK5 CLIC5 SRGAP1

2.65e-051851406b848b63aff4d9dbb9e66a85876d4c7c6dacd0579
ToppCellLPS-antiTNF-Myeloid|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ITGAX ACOD1 DOCK5 PTPRJ IL1A KYNU

2.73e-051861406839c6da5244f469461b2e5563e36162b2911cd01
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

NEBL PARP4 FAT1 FUT9 PLEKHH2 HYDIN

2.99e-051891406904b8337e2cabac2f0bf5dad5598fc429581ed81
ToppCellCOVID-19-Heart|COVID-19 / Disease (COVID-19 only), tissue and cell type

FLNC ABCC9 ABCA8 CLIC5 PTPRG CTNND2

3.08e-051901406918ad5037881212008f9f69d5df5da91fd01422c
ToppCell10x_3'_v2v3-Non-neoplastic-Glial-Neuronal-OPC-OPC-G|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

GPR155 GRIK2 CSMD3 CSPG4 PCDH15 KIF13A

3.08e-0519014066c7e1086c0a274cd5527c3104106e372811c9905
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

NEBL PARP4 FAT1 FUT9 PLEKHH2 HYDIN

3.17e-051911406d0e9afe7b6334dd515d3e68892efdc76347a55e5
ToppCellPCW_10-12-Mesenchymal-Mesenchymal_myocytic-mes_immature_ASM1_(8)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

NEBL ENC1 PAQR5 DOCK5 FAT1 PTPRG

3.26e-0519214064c9d748f209cc1e13d28c8c7f5180ab8522e0fbf
ToppCellfacs-Aorta-Heart-3m|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CAB39 USP9X PARP1 PTPRG HYDIN TOP2B

3.26e-0519214061ccc47792edf9ee23501c8e2165d11271636b66a
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

TRABD2B NEBL PAQR5 SLC3A1 TINAG PTPRJ

3.36e-05193140682e8a4c40299ffcdfd5a0da711bb9de6fb8a2eaa
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

TRABD2B NEBL PAQR5 FAT1 TINAG PTPRJ

3.36e-0519314063866667dd221612589ae50f5c52f73a183a49ce6
ToppCellFetal_29-31_weeks-Mesenchymal-matrix_fibroblast_1_cell|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

CSMD3 ABCA8 PTPRG SRGAP1 PCDH15 PLEKHH2

3.46e-051941406011e14d9ed1393275f892060e7708ffadcd0767f
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

NEBL PAQR5 SLC3A1 FAT1 PTPRJ HYDIN

3.46e-05194140693c68c31e39fa44c1d05d7d4997f4f086da4e738
ToppCellPCW_07-8.5-Mesenchymal-Mesenchymal_myocytic-mes_immature_ASM1_(8)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

NEBL ENC1 PAQR5 DOCK5 FAT1 NSG1

3.46e-051941406fb80a0271ccb1cb3f954ebcf2c5945cb6adb6b8c
ToppCellCOVID-19-Fibroblasts-Alveolar_FB|COVID-19 / group, cell type (main and fine annotations)

NEBL ABCA8 PTPRG SRGAP1 PCDH15 PLEKHH2

3.56e-051951406603050beeb33c331d4b2e3fa46cae3f3e0e4bdc7
ToppCelldroplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MIA3 MYCBP2 USP9X NBEA ABCC8 UTY

3.56e-0519514063e519cffa6144a62b06124642a14c9ff39b76554
ToppCelldroplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MIA3 MYCBP2 USP9X NBEA ABCC8 UTY

3.56e-0519514067796ea9247f4c63762f0de8490fed08b9717fa23
ToppCellCOPD-Endothelial-VE_Capillary_B|Endothelial / Disease state, Lineage and Cell class

STARD13 PTPRG ABCC8 PCDH15 EPAS1 ANKS1A

3.76e-05197140630dbc05ea66892d2e18ff375ffa86d1db7bc4083
ToppCellParenchymal-10x5prime-Stromal-Mesofibroblastic|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

GRIK2 EPGN PKHD1L1 ABCA8 C4A C4B

3.76e-05197140688a86286b9c3ea3b076d7464faec42d0392ee7f8
ToppCellParenchymal-10x5prime-Stromal-Mesofibroblastic-Mesothelia|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

GRIK2 EPGN PKHD1L1 ABCA8 C4A C4B

3.76e-0519714062773d2eb5f232a7e49da116efffcb6bf5eb90810
ToppCellTracheal-NucSeq-Stromal-Schwann-Schwann_nonmyelinating|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

GPR155 TRABD2B GRIK2 CSMD2 ABCA8 RORB

3.76e-0519714065c88a97e8e23a5cd61885acbe1ef339ae6a1e35a
ToppCellBiopsy_Other_PF-Mesenchymal-Mesothelial_cells|Biopsy_Other_PF / Sample group, Lineage and Cell type

FLNC EPGN PKHD1L1 NSG1 C4A C4B

3.87e-05198140686736f01e61bf4961f060b24ee1f1f48340737dd
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-OPC|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

HECW1 CSMD2 CSMD3 ABCC8 CSPG4 PCDH15

3.98e-051991406333056c2abe9724efeab542c0365fcfe4eff8f18
ToppCellBiopsy_Control_(H.)-Mesenchymal-Mesothelial_cells|Biopsy_Control_(H.) / Sample group, Lineage and Cell type

FLNC EPGN PKHD1L1 ABCA8 C4A C4B

3.98e-051991406ca970114b5aef4518ce580897a62ac88688b2671
ToppCellNeuron-Postmitotic-Excitatory_Neuron_-Parietal_and_Temporal-6|World / Primary Cells by Cluster

NBEA NSG2 CSRNP3 SRGAP1 NSG1 RORB

3.98e-0519914061b1bccf4293f11048709d15a3c892c0edf3da3d2
ToppCellNeuron|World / Primary Cells by Cluster

ENC1 NBEA NSG2 CSRNP3 SRGAP1 NSG1

3.98e-0519914061f8104fd92f04690b41d9d07ac08dc59d76bb97d
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-OPC-OPC|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

HECW1 CSMD2 CSMD3 ABCC8 CSPG4 PCDH15

3.98e-051991406e60ecbb8fa7bcd3e2ce7d78f6efb2cfd1fd77698
ToppCellNeuron-Postmitotic|World / Primary Cells by Cluster

ENC1 NBEA NSG2 CSRNP3 SRGAP1 NSG1

3.98e-0519914061973527f8a7d4c6490d75c0d0ea153688166a08b
ToppCellNeuron-Postmitotic-Excitatory_Neuron_-Parietal_and_Temporal|World / Primary Cells by Cluster

NBEA NSG2 CSRNP3 SRGAP1 NSG1 RORB

3.98e-0519914064bee94c116c0da5eba951cb4cea7cc9dcdd6e30f
ToppCellNeuron-Postmitotic-Excitatory_Neuron_|World / Primary Cells by Cluster

ENC1 NBEA NSG2 CSRNP3 SRGAP1 NSG1

3.98e-051991406058373b4ac3cec2108cb24265628ff0a50646e33
ToppCellFetal_brain-fetalBrain_Zhong_nature-GW26-Neuronal-GABAergic_neurons|GW26 / Sample Type, Dataset, Time_group, and Cell type.

MYCBP2 NBEA NSG2 CSRNP3 NSG1 AGTPBP1

4.10e-052001406bad32a95b759fad509401b07bc96a56687c2a592
ToppCellFrontal_cortex-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Sst-Inhibitory_Neuron.Gad1Gad2.Sst-Nr2f2_(MGE-derived_cortical_interneurons--Martinotti_cells)|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

MYH8 PKHD1L1 ACOD1 TAF9

4.35e-05621404a20620a8869721ea62984c2022ee1b484b455824
ToppCellFrontal_cortex-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Sst-Inhibitory_Neuron.Gad1Gad2.Sst-Nr2f2_(MGE-derived_cortical_interneurons--Martinotti_cells)-|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

MYH8 PKHD1L1 ACOD1 TAF9

4.35e-05621404ee694c06bcd924b4ddf744178ba3a99e04eed51b
ToppCellfrontal_cortex-Neuronal-glutamatergic_neuron-L6_IT-L6_IT_VISp_Col23a1_Adamts2|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

MYH2 FGF16 PLET1 VWA3B

5.25e-05651404f14b28214f80ed23501ab28ff254c206f70d77b2
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_2|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

TRABD2B GPR82 F5 TINAG ABCC8

5.28e-051281405e100629f6038e32176ffcc81bd06bd175df46cef
ToppCellfacs-Pancreas-Exocrine-24m-Endothelial-nan|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HECW1 PAQR5 GRIK2 PKHD1L1 FUT9

5.69e-0513014058c81853c806e9a0d562e00dc5e00a8fc569a854c
ToppCellfacs-Pancreas-Exocrine-24m-Endothelial-endothelial_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HECW1 PAQR5 GRIK2 PKHD1L1 FUT9

5.69e-0513014053041d20fe964d282d95c0312396f26bc93929056
ToppCellfacs-Pancreas-Exocrine-24m-Endothelial|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HECW1 PAQR5 GRIK2 PKHD1L1 FUT9

5.69e-0513014053b6a8eaef593db73c2fad2260b9f1e15950ccb70
ToppCellprimary_visual_cortex-Neuronal-glutamatergic_neuron-L6b-L6b_P2ry12|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

TRABD2B FGF16 CLIC5 KYNU EPAS1

5.90e-05131140580630812f8894b9358d36dc2dd03fea7ee870502
ToppCellMild/Remission-B_naive-1|Mild/Remission / disease group and sub_cluster of B and Plasma cells(res = 0.5)

WASHC4 ICE2 ICE1 PLEKHH2 RAB29

8.93e-051431405bd3f5fbd4e9e4dc414682db5607494f3ce988deb
ToppCellPosterior_cortex-Neuronal-Excitatory-eN1(Slc17a7)-eN1_1-Bcl6|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

DCHS2 MIA3 FGF16 CCDC87 HYDIN

9.23e-05144140508005be9e3367f78ef27e125d9cce5ca53f4bd2d
ToppCellFrontal_cortex-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

MYH2 TRABD2B SV2B ABCC8 FUT9

1.23e-041531405b37a1ecad389d2848b8ca4d287823e8048207420
ToppCellfacs-Marrow-KLS-18m-Lymphocytic|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NEBL ABCC9 ITGAX FAT1 C4A

1.27e-04154140537765512dfae557b9f6eb30a29463b93682a4404
ToppCellFetal_brain-fetalBrain_Zhong_nature-GW19-Neuronal|GW19 / Sample Type, Dataset, Time_group, and Cell type.

ENC1 NSG2 CSRNP3 NSG1

1.30e-04821404dadc97c81e44858f60687145316102fc10ecc13e
ToppCelllung-Type_I_Pneumocytes|lung / shred on tissue and cell subclass

PLEKHG1 CLIC5 NSG1 RNF180

1.30e-048214046023212a51f8b3e05e6c3dcf4e8fbf53ba696fb2
ToppCell3'_v3-lymph-node_spleen-Lymphocytic_T_CD4/8-lo-Trm_Tgd|lymph-node_spleen / Manually curated celltypes from each tissue

SLC3A1 NUP205 DOCK5 PLEKHH2 EPAS1

1.30e-041551405b0e456c4915076e1d38282e116a6eb3230ae80dc
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

NEBL MUC19 EPGN FAT1 CLIC5

1.47e-0415914058680b054622f573a82b1625fb93c2d5db81d1034
ToppCellsaliva-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD8_c01-LEF1|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

ABCA8 ORMDL3 CLIC5 ZNF606 ZMAT1

1.47e-0415914052233fee5dcdb6c7dee5b1bd8efbc07d86b339927
ToppCellPCW_13-14-Hematologic_Myeloid-Hem_Myeloid_macrophage-im_macrophage_(16)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

ITGAX ACOD1 BTK IL1A KYNU

1.51e-04160140508696d93ff42a1beca23c70ab3e0d082cfff4aa7
ToppCellfacs-MAT-Fat-24m-Myeloid-myeloid_cell|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KDM6B F5 ACOD1 IL1A RNF180

1.56e-04161140565888250b8c1da6a8f9b5376e086a3769a1cbbd8
ComputationalComplement.

CR2 C4A C4B C4BPA

2.88e-0523854MODULE_130
DiseaseColorectal Carcinoma

FLNC POLD1 POLE CSMD3 F5 ABCA8 ADCY8 HPS3 PARP1 FAT1 CSRNP3 ABCC8 ABCG2 CTNND2 AGTPBP1

1.01e-0670213715C0009402
Diseasepneumococcal bacteremia

LAMB4 OR6P1 DOCK7

1.57e-05111373EFO_1001925
DiseaseColorectal Neoplasms

FLNC POLD1 POLE ABCA8 PARP1 FAT1 ABCC8 ABCG2

4.79e-052771378C0009404
DiseaseDrug habituation

GRIK2 CSMD3 CSRNP3 PCDH15 ZNF606

2.04e-041151375C0013170
DiseaseDrug abuse

GRIK2 CSMD3 CSRNP3 PCDH15 ZNF606

2.04e-041151375C0013146
DiseasePrescription Drug Abuse

GRIK2 CSMD3 CSRNP3 PCDH15 ZNF606

2.04e-041151375C4316881
DiseaseSubstance-Related Disorders

GRIK2 CSMD3 CSRNP3 PCDH15 ZNF606

2.04e-041151375C0236969
DiseaseDrug Use Disorders

GRIK2 CSMD3 CSRNP3 PCDH15 ZNF606

2.04e-041151375C0013222
DiseaseDrug Dependence

GRIK2 CSMD3 CSRNP3 PCDH15 ZNF606

2.04e-041151375C1510472
DiseaseSubstance Dependence

GRIK2 CSMD3 CSRNP3 PCDH15 ZNF606

2.04e-041151375C0038580
DiseaseSubstance Use Disorders

GRIK2 CSMD3 CSRNP3 PCDH15 ZNF606

2.04e-041151375C0038586
DiseaseOrganic Mental Disorders, Substance-Induced

GRIK2 CSMD3 CSRNP3 PCDH15 ZNF606

2.04e-041151375C0029231
DiseaseLipodystrophy

POLD1 PARP2

2.12e-0451372C0023787
DiseaseDiGeorge syndrome (is_implicated_in)

DVL1P1 DVL1

2.12e-0451372DOID:11198 (is_implicated_in)
DiseaseSubstance abuse problem

GRIK2 CSMD3 CSRNP3 PCDH15 ZNF606

2.13e-041161375C0740858
Diseasevenous thromboembolism, fibrinogen measurement

DCHS2 F5 PTPRJ C4BPA

2.72e-04671374EFO_0004286, EFO_0004623
Diseaserenal cell carcinoma (is_implicated_in)

C4A C4B ABCG2 RNF139

3.04e-04691374DOID:4450 (is_implicated_in)
DiseasePituitary Gland Adenoma

NEBL PCDH15

3.17e-0461372EFO_1000478
Diseasegout

ABCC9 FAT1 CLIC5 SV2B ABCC8 ABCG2

3.18e-041961376EFO_0004274
Diseasethyroid peroxidase antibody measurement

NEBL CSMD2 DICER1 RORB

3.58e-04721374EFO_0005666
DiseaseEndometrial Carcinoma

PLXNA3 POLD1 POLE ABCC9

3.58e-04721374C0476089
DiseaseCardiomyopathies

NEBL ABCC9 PARP1 TMEM70 IL1A

3.61e-041301375C0878544
Diseasefactor XI measurement, venous thromboembolism

F5 PTPRJ C4BPA

3.63e-04301373EFO_0004286, EFO_0004694
DiseaseCerebral ventriculomegaly

SIN3A HYDIN

4.43e-0471372C1531647
DiseaseB-cell lymphoma (is_implicated_in)

BTK ABCG2

4.43e-0471372DOID:707 (is_implicated_in)
DiseaseHydrocephalus Ex-Vacuo

SIN3A HYDIN

4.43e-0471372C0270720
DiseaseCommunicating Hydrocephalus

SIN3A HYDIN

4.43e-0471372C0009451
DiseaseFetal Cerebral Ventriculomegaly

SIN3A HYDIN

4.43e-0471372C2936718
DiseasePost-Traumatic Hydrocephalus

SIN3A HYDIN

4.43e-0471372C0477432
DiseaseObstructive Hydrocephalus

SIN3A HYDIN

4.43e-0471372C0549423
Diseasefactor VIII measurement, venous thromboembolism

F5 PTPRJ C4BPA

5.27e-04341373EFO_0004286, EFO_0004630
Diseasedilated cardiomyopathy (implicated_via_orthology)

MYH2 FLNC MYH8 DICER1

5.35e-04801374DOID:12930 (implicated_via_orthology)
DiseaseCongenital Hydrocephalus

SIN3A HYDIN

5.88e-0481372C0020256
DiseaseAqueductal Stenosis

SIN3A HYDIN

5.88e-0481372C2936786
Diseasevenous thromboembolism, factor VII measurement

F5 PTPRJ C4BPA

7.33e-04381373EFO_0004286, EFO_0004619
DiseaseHydrocephalus

SIN3A HYDIN

7.54e-0491372C0020255
Diseaseautosomal dominant hyaline body myopathy (implicated_via_orthology)

MYH2 MYH8

9.40e-04101372DOID:0111269 (implicated_via_orthology)
Diseasedistal arthrogryposis type 2B3 (implicated_via_orthology)

MYH2 MYH8

9.40e-04101372DOID:0111602 (implicated_via_orthology)
Diseasedistal arthrogryposis type 1 (implicated_via_orthology)

MYH2 MYH8

9.40e-04101372DOID:0111596 (implicated_via_orthology)
Diseasedilated cardiomyopathy 1S (implicated_via_orthology)

MYH2 MYH8

9.40e-04101372DOID:0110454 (implicated_via_orthology)
Diseasecongenital myopathy 6 (implicated_via_orthology)

MYH2 MYH8

9.40e-04101372DOID:0080719 (implicated_via_orthology)
Diseaseinclusion body myositis (implicated_via_orthology)

MYH2 MYH8

9.40e-04101372DOID:3429 (implicated_via_orthology)
Diseasedistal arthrogryposis type 2A (implicated_via_orthology)

MYH2 MYH8

9.40e-04101372DOID:0111605 (implicated_via_orthology)
Diseasefamilial hypertrophic cardiomyopathy (implicated_via_orthology)

MYH2 MYH8

9.40e-04101372DOID:0080326 (implicated_via_orthology)
Diseasevenous thromboembolism, von Willebrand factor measurement

F5 PTPRJ C4BPA

9.85e-04421373EFO_0004286, EFO_0004629
Diseasereticulocyte count

USP9X ENC1 TMEM235 ITGAX OR6P1 ADCY8 PLEK2 DOCK5 FAT1 PTPRJ TBK1 C4B C4BPA

1.19e-03104513713EFO_0007986
Diseasereticulocyte measurement

USP9X ENC1 TMEM235 KDM6B ITGAX ADCY8 PLEK2 DOCK5 FAT1 PTPRJ TBK1 RORB C4BPA

1.28e-03105313713EFO_0010700
Diseasedistal myopathy (implicated_via_orthology)

MYH2 MYH8

1.37e-03121372DOID:11720 (implicated_via_orthology)
Diseasemyotonia congenita (implicated_via_orthology)

MYH2 MYH8

1.37e-03121372DOID:2106 (implicated_via_orthology)
DiseaseAutistic Disorder

GPR155 NBEA GRIK2 CSMD3 SND1 C4B

1.42e-032611376C0004352
Diseasemyopathy (implicated_via_orthology)

MYH2 FLNC MYH8

1.45e-03481373DOID:423 (implicated_via_orthology)
Diseaserestrictive cardiomyopathy (implicated_via_orthology)

MYH2 MYH8

1.61e-03131372DOID:397 (implicated_via_orthology)
Diseasecancer (implicated_via_orthology)

CAB39 POLE SIN3A BRCA2 EPAS1 TOP2B

1.62e-032681376DOID:162 (implicated_via_orthology)
Diseaselung carcinoma, estrogen-receptor negative breast cancer, ovarian endometrioid carcinoma, colorectal cancer, prostate carcinoma, ovarian serous carcinoma, breast carcinoma, ovarian carcinoma, lung adenocarcinoma, squamous cell lung carcinoma

DVL1P1 DVL1 BRCA2

1.83e-03521373EFO_0000305, EFO_0000571, EFO_0000708, EFO_0001071, EFO_0001075, EFO_0001663, EFO_1000650, EFO_1001515, EFO_1001516, MONDO_0005575
Diseasefree androgen index

MYH2 SIN3A ABCA8 DOCK5 PTPRG RORB EPAS1

1.87e-033741377EFO_0007005
Diseasereceptive language perception, parental genotype effect measurement

MUC19 PLEKHG1

1.88e-03141372EFO_0005686, EFO_0005939
DiseaseHMG CoA reductase inhibitor use measurement

TDRD15 MIA3 DHRS11 BRCA2 DOCK7

1.93e-031891375EFO_0009932
Diseasemacula measurement

DCHS2 STAT2 FAT1 RORB CTNND2

1.93e-031891375EFO_0008375
Diseaseperipheral arterial disease

NEBL CSMD3 F5

2.04e-03541373EFO_0004265
Diseaselifestyle measurement, alcohol consumption measurement

GRIK2 CSMD2 ADCY8 NUP205

2.06e-031151374EFO_0007878, EFO_0010724
Diseasesleep apnea measurement

HECW1 NEBL NBEA SND1

2.13e-031161374EFO_0007817
Diseasephenylalanine measurement

WASHC4 PCDH15 KIF13A

2.15e-03551373EFO_0005001
Diseaseplatelet storage pool deficiency (implicated_via_orthology)

HPS3 DOCK7

2.16e-03151372DOID:2223 (implicated_via_orthology)
Diseasedistal arthrogryposis (implicated_via_orthology)

MYH2 MYH8

2.16e-03151372DOID:0050646 (implicated_via_orthology)
Diseaseresponse to statin, LDL cholesterol change measurement

TDRD15 ABCG2

2.16e-03151372EFO_0007804, GO_0036273
Diseaseresponse to calcium channel blocker

MUC19 SND1 PCDH15

2.27e-03561373EFO_0007767
Diseasetestosterone measurement

STARD13 MYH2 DCHS2 MIA3 ICE2 SIN3A KDM6B CSMD3 ABCA8 DOCK5 PTPRG PTPRJ RORB EPAS1

2.48e-03127513714EFO_0004908
Diseasecolorectal cancer (is_implicated_in)

POLE DICER1 FAT1 PTPRJ

2.48e-031211374DOID:9256 (is_implicated_in)
DiseaseEndometrial Neoplasms

PLXNA3 POLD1 ABCC9

2.51e-03581373C0014170
DiseaseBrain Ischemia

F5 PARP1 IL1A

2.76e-03601373C0007786
DiseaseCerebral Ischemia

F5 PARP1 IL1A

2.76e-03601373C0917798
DiseaseMultiple congenital anomalies

POLD1 KYNU

2.78e-03171372C0000772
DiseaseHypogammaglobulinemia

CR2 BTK

2.78e-03171372C0086438
Diseasesystemic lupus erythematosus (is_implicated_in)

CR2 C4A C4B

3.03e-03621373DOID:9074 (is_implicated_in)
Diseasetotal lipids in small VLDL

TDRD15 DOCK7 HSD17B4

3.78e-03671373EFO_0022148
DiseaseDeaf Mutism

POLD1 PCDH15

3.85e-03201372C4082305
DiseaseDeafness, Acquired

POLD1 PCDH15

3.85e-03201372C0751068
DiseaseHearing Loss, Extreme

POLD1 PCDH15

3.85e-03201372C0086395
DiseaseComplete Hearing Loss

POLD1 PCDH15

3.85e-03201372C0581883
DiseaseBilateral Deafness

POLD1 PCDH15

3.85e-03201372C3665473
DiseasePrelingual Deafness

POLD1 PCDH15

3.85e-03201372C0011052
Diseaselung non-small cell carcinoma (is_implicated_in)

POLE FAT1 IL1A EPAS1

4.08e-031391374DOID:3908 (is_implicated_in)
DiseaseCardiomyopathies, Primary

PARP1 TMEM70 IL1A

4.10e-03691373C0033141
DiseaseMyocardial Diseases, Secondary

PARP1 TMEM70 IL1A

4.10e-03691373C0036529
DiseaseLupus Erythematosus, Systemic

CR2 C4A C4B

4.44e-03711373C0024141

Protein segments in the cluster

PeptideGeneStartEntry
ISYHQLEAFYSIFTT

PTPRG

276

P23470
FSLHVLSKINIFYYS

TMEM62

471

Q0P6H9
VVRKDTTSHTYLQYS

ADCY8

231

P40145
HYKQSSSYSFFKEEI

C4BPA

436

P04003
TQYQDYSLSSAHKVS

EPAS1

806

Q99814
EHLTLTSYAVDSYEK

EPGN

96

Q6UW88
IYFSTLDYQDTTVHK

CATSPER3

351

Q86XQ3
QLYLHFYSDISVSAA

CSMD2

1881

Q7Z408
FKIHYESVTVNTYSC

CSMD3

996

Q7Z407
HLFVKSLNSASYLYE

CSPG4

921

Q6UVK1
DVHTAESISYQKLYN

CNTLN

371

Q9NXG0
YNYLDKNLTVSVHVS

C4B

856

P0C0L5
QSQYYLAEKHLFSTI

BTK

341

Q06187
ILKHSSLFLDSYTEY

ALS2

771

Q96Q42
YVNSSFYKETKAELH

ABCG2

336

Q9UNQ0
FSEYEKLLHSENYVT

CAB39

211

Q9Y376
NPEEHATYYFTTFSK

DOP1A

311

Q5JWR5
TTSIVYYHNIETSNF

ABCC9

116

O60706
TFAYITKDLQTSHHY

ANKS1A

1021

Q92625
TLSVDDYFKYLTNHE

CCDC87

591

Q9NVE4
NNTIFASLAVKYDYH

DICER1

1741

Q9UPY3
YYTITFTVNFPHKDD

AGTPBP1

826

Q9UPW5
LNTHEYDFVSVYTIK

CLIC5

51

Q9NZA1
QYSKHSQELYATATL

CTNND2

371

Q9UQB3
YVLVYSVTSLHSFQV

RHEBL1

81

Q8TAI7
RYSQDSFSKHYKSTV

RAB29

26

O14966
KYAVYTVVSSHEQFT

ITGAX

921

P20702
TVVSSHEQFTKYLNF

ITGAX

926

P20702
KYVKNTHATTHNAYD

PARP1

816

P09874
FFSYYDSHRQSVSKL

NUP205

1826

Q92621
EINYYFRSTAQSTKH

PCDHGB6

276

Q9Y5F9
SYEFKVISQYLQSTH

PARP2

376

Q9UGN5
TTFHDYYVALAVLNT

PAQR5

146

Q9NXK6
KIHATDQDVYDTLTY

FAT1

3566

Q14517
YTKYDAAHFLINTAS

ORMDL2

116

Q53FV1
DHLSLNQKSFYHVSY

IL1A

26

P01583
SNDTAASEYKYVVKH

PTPRJ

141

Q12913
VVLTSYYSFVSHLRK

GPR82

216

Q96P67
SVVNHTSLSNYAFLY

GPR155

306

Q7Z3F1
VLHANYSAYRVFTSS

HECW1

966

Q76N89
YLSFENSIHKDYITE

FUT9

241

Q9Y231
SRSHTTIAKYAQYQA

KDM6B

1271

O15054
RTKNVHFSCVTVYYF

CSRNP3

61

Q8WYN3
AYHVESKVYAVATST

CPSF1

1026

Q10570
KAERSYHIFYQITSN

MYH8

281

P13535
SVAAYTYRQHSVVFI

PLXNA3

416

P51805
ASSSYLQVETYFHVK

MUC19

911

Q7Z5P9
YSYNLCIASHSAKTE

PCDHGB1

746

Q9Y5G3
KAERSYHIFYQITSN

MYH2

281

Q9UKX2
RFYTVISHYSVAKQS

NSG2

131

Q9Y328
IDNHDYSYTVKYTAV

FLNC

921

Q14315
ASSVVYSATKDYKDH

PI4KA

686

P42356
LTAHSNYTQKTLKYF

LMNTD1

116

Q8N9Z9
DSSAREKFYTVINHY

NSG1

136

P42857
ISLKKNTHTYFYTSF

HM13

281

Q8TCT9
KQHTFTLAQYTYVAL

MOCOS

346

Q96EN8
YVEYITSSIHSKETF

POLE

1886

Q07864
IYFSDSLSTSIKYSH

PARP4

476

Q9UKK3
VQLTTEKHTYYLTAD

PLEKHH2

766

Q8IVE3
SLHSSAVAATYKYVN

NDUFS8

26

O00217
LFLSKELDYETTSHY

DCHS2

1461

Q6V1P9
VVHFYDDKVQSTYFL

KICS2

381

Q96MD2
LLQSKSELSHYTFYF

PAQR8

131

Q8TEZ7
TFKHESYYATVNELT

PCDH15

146

Q96QU1
YTFNHNKIISVLYTI

OR6P1

266

Q8NGX9
DQHVYKAVFTTSYPS

HENMT1

246

Q5T8I9
ASLVNYSFDTKDIHY

HYDIN

1381

Q4G0P3
ETQIVASDHTYYNSK

ICE1

1531

Q9Y2F5
VKKYSEFYTLHEVTS

ICE2

186

Q659A1
KTHSAYSHNDIVYVD

CR2

801

P20023
DSHYSHYISTFKTRQ

DOCK5

966

Q9H7D0
FSKEAYTAVVYHNRS

DOCK7

611

Q96N67
ITSHSDKITFHPYYT

MT-CYB

211

P00156
KTNKFIYAIHDETSY

BRCA2

586

P51587
VVQYAKEVVDFSSHY

FBXL4

51

Q9UKA2
FIYTTSNHIKYAVTT

COPA

541

P53621
YSYSEKELICHNQFS

HSD17B4

446

P51659
TTEVFHIASQYSKIY

ACOD1

46

A6NK06
DSSENIKKYYHISSS

LAMB4

1306

A4D0S4
RHTVNKITFSEQCYY

DVL1

481

O14640
YLFHKSSYADSVLTH

ENC1

21

O14682
ESTHKYYETVSDVLN

COG2

641

Q14746
RHTVNKITFSEQCYY

DVL1P1

456

P54792
HQVSDNKDSFYVSLY

GRIK2

136

Q13002
SVTHFYSATKYAVTA

DHRS11

161

Q6UWP2
LHYSFQTTEKLYFVL

SGK3

226

Q96BR1
EYKLRSYTLNAVSFH

POLD1

466

P28340
YNYLDKNLTVSVHVS

C4A

856

P0C0L4
FLTSFYTKYDQIHFV

ORMDL3

111

Q8N138
YTKYDQIHFVLNTVS

ORMDL3

116

Q8N138
YEIHSKTTAYSRLNE

RNF180

246

Q86T96
QYTVTFSHCKDYVVN

KIF13A

921

Q9H1H9
TSVLVNYYASLHIDF

RNF139

91

Q8WU17
YVTTILDDAKIYSSH

TAF9B

46

Q9HBM6
YVTTILDDAKIYSSH

TAF9

46

Q16594
STTSYKVVHSFDYAA

UTP15

276

Q8TED0
NEVNKVISSVSYYTH

USP9X

356

Q93008
ESNRSHTTIAKYAQY

UTY

971

O14607
HTTIAKYAQYQASSF

UTY

976

O14607
NLSSKESSFIHYYCV

SENP7

666

Q9BQF6
LSETFLHIYQYVSKE

STARD13

751

Q9Y3M8
TLEATNASVFKYYIH

SRGAP1

246

Q7Z6B7
EELHIISFTVKYTYQ

STAT2

426

P52630
SDYKEYHTDTTVKFV

TOP2B

976

Q02880
STIFYNTDLYEHKFI

SV2B

496

Q7L1I2
TVDYFTSKVHNKTVY

TDRD15

1426

B5MCY1
YFVRYKHSTAEETAT

MIA3

1026

Q5JRA6
YTQYEDESFTKHTVN

F5

396

P12259
YSNTYKTVKTQSCIH

HPS3

506

Q969F9
TYASTLYKHSDSERQ

FGF16

146

O43320
HTNTVTVTTYNTLYE

NBEA

801

Q8NFP9
FTKSISLLFHSINYY

GPR108

301

Q9NPR9
QTESKGSFSIQYTYH

SEMG1

56

P04279
TFVSSKKTQYEEHIY

SIN3A

596

Q96ST3
ALSKVHFTAERSSYY

SND1

626

Q7KZF4
TQYSELYHDFTTTQV

SLC3A1

341

Q07837
SLASIHADKYSYTID

SLC26A10

296

Q8NG04
SYSVVASEYDKQHSI

MYCBP2

3476

O75592
ITAKFTALYSLSQYH

ARHGAP5

911

Q13017
TTVVYNLTHEDSIKY

RNF217

316

Q8TC41
RVTFTNTYSYHLKFL

ABCA8

126

O94911
AAVTSVVYYHNIETS

ABCC8

116

Q09428
YTITLDIKASSHIYE

PLET1

41

Q6UQ28
DIKASSHIYESNAVY

PLET1

46

Q6UQ28
TKDDTHYYIQASSKA

PLEK2

326

Q9NYT0
ANTSTSFYKLVYTAI

ZNF678

16

Q5SXM1
IYISYSHLAFAETVQ

TMEM235

146

A6NFC5
YTHAANTVVYSSNKI

WDR82

71

Q6UXN9
SLQASYTTEDLIKHY

TRABD2B

241

A6NFA1
QTHTYEEIKAYQSKS

RORB

251

Q92753
HKASESQSFYVDVVY

PKHD1L1

816

Q86WI1
SFYLKEQTFYHVASD

TXNDC11

501

Q6PKC3
HYLDKTFYNLTTVAL

WASHC4

731

Q2M389
SSEYHENKKSYQTSV

ZNF510

376

Q9Y2H8
FVSKSEEFHIYTQYC

PLEKHG1

191

Q9ULL1
LSYIHVTVDTYSHFI

ERVK-19

666

Q9WJR5
KSFSYSSHYITHQTI

ZNF23

231

P17027
YQFVEHLTQAVESYK

VWA3B

106

Q502W6
IYRHVTSTNKESEKY

TINAG

391

Q9UJW2
YHEATTDTYKAITYN

TMEM70

171

Q9BUB7
AHKIYIHSYNTATIF

TBK1

321

Q9UHD2
ADSVYKYNIFRSTFH

ZNF181

151

Q2M3W8
FLTQHTSTYTAEKPY

ZNF606

386

Q8WXB4
YSVESEVYKHLSSEN

ZMAT1

511

Q5H9K5
YNSFHDVYKFTNLLT

KYNU

441

Q16719
IHSNTYNYKSTFSVE

NMD3

231

Q96D46
ISYRKDVQDTHTYSA

NEBL

161

O76041