Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionlow voltage-gated calcium channel activity

CACNA1I CACNA1G

2.66e-053602GO:0008332
GeneOntologyMolecularFunctionN-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity

CHSY1 CHSY3

5.31e-054602GO:0050510
GeneOntologyMolecularFunctionglucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity

CHSY1 CHSY3

1.32e-046602GO:0047238
GeneOntologyBiologicalProcessvesicle tethering to endoplasmic reticulum

STARD3 STARD3NL

8.32e-062602GO:0099044
GeneOntologyCellularComponentendoplasmic reticulum-endosome membrane contact site

STARD3 STARD3NL

4.84e-054602GO:0140284
DomainMENTAL

STARD3 STARD3NL

1.05e-052612IPR019498
DomainNPFF_rcpt

NPFFR2 NPFFR1

1.05e-052612IPR005395
DomainMENTAL

STARD3 STARD3NL

1.05e-052612PF10457
DomainMENTAL

STARD3 STARD3NL

1.05e-052612PS51439
DomainVDCC_T_a1

CACNA1I CACNA1G

3.14e-053612IPR005445
DomainChond_GalNAc

CHSY1 CHSY3

2.90e-048612IPR008428
DomainCHGN

CHSY1 CHSY3

2.90e-048612PF05679
DomainVDCCAlpha1

CACNA1I CACNA1G

4.64e-0410612IPR002077
DomainDynein_heavy_chain_D4_dom

DNAH2 DNAH14

9.31e-0414612IPR024317
DomainDynein_HC_stalk

DNAH2 DNAH14

9.31e-0414612IPR024743
DomainMT

DNAH2 DNAH14

9.31e-0414612PF12777
DomainAAA_8

DNAH2 DNAH14

9.31e-0414612PF12780
DomainDHC_fam

DNAH2 DNAH14

1.07e-0315612IPR026983
DomainDynein_heavy_dom

DNAH2 DNAH14

1.07e-0315612IPR004273
DomainDynein_heavy

DNAH2 DNAH14

1.07e-0315612PF03028
DomainUDENN

SBF1 DENND4C

1.22e-0316612PS50946
DomainDDENN

SBF1 DENND4C

1.22e-0316612PS50947
DomainDENN

SBF1 DENND4C

1.22e-0316612SM00799
DomaindDENN

SBF1 DENND4C

1.22e-0316612SM00801
DomainDENN

SBF1 DENND4C

1.22e-0316612PF02141
DomaindDENN_dom

SBF1 DENND4C

1.22e-0316612IPR005112
DomainuDENN_dom

SBF1 DENND4C

1.22e-0316612IPR005113
DomaindDENN

SBF1 DENND4C

1.22e-0316612PF03455
DomainDENN

SBF1 DENND4C

1.22e-0316612PS50211
DomainDENN_dom

SBF1 DENND4C

1.22e-0316612IPR001194
Domain7TM_GPCR_Srsx

NPFFR2 DRD1 NPFFR1

5.87e-03112613SM01381
DomainGPCR_Rhodpsn_7TM

NPFFR2 DRD1 OR5M9 GPR27 GPR55 GPR87 NPFFR1

6.03e-03670617IPR017452
Domain7tm_1

NPFFR2 DRD1 OR5M9 GPR27 GPR55 GPR87 NPFFR1

6.37e-03677617PF00001
DomainG_PROTEIN_RECEP_F1_1

NPFFR2 DRD1 OR5M9 GPR27 GPR55 GPR87 NPFFR1

6.78e-03685617PS00237
DomainG_PROTEIN_RECEP_F1_2

NPFFR2 DRD1 OR5M9 GPR27 GPR55 GPR87 NPFFR1

7.10e-03691617PS50262
DomainGPCR_Rhodpsn

NPFFR2 DRD1 OR5M9 GPR27 GPR55 GPR87 NPFFR1

7.15e-03692617IPR000276
Pubmed

Opposite control of body temperature by NPFF1 and NPFF2 receptors in mice.

NPFFR2 NPFFR1

3.03e-06261220554321
Pubmed

Functional characterization of the MENTAL domain.

STARD3 STARD3NL

3.03e-06261215718238
Pubmed

Unravelling neurotransmitters impairment in primary progressive aphasias.

SLC6A4 DRD1

3.03e-06261236649260
Pubmed

RFamide-related peptide-3 receptor gene expression in GnRH and kisspeptin neurons and GnRH-dependent mechanism of action.

NPFFR2 NPFFR1

3.03e-06261222691552
Pubmed

Silencing of renal DNaseI in murine lupus nephritis imposes exposure of large chromatin fragments and activation of Toll like receptors and the Clec4e.

CLEC4E DNASE1

3.03e-06261222479529
Pubmed

Contribution of postsynaptic T-type calcium channels to parallel fibre-Purkinje cell synaptic responses.

CACNA1I CACNA1G

3.03e-06261226627919
Pubmed

MENTHO, a MLN64 homologue devoid of the START domain.

STARD3 STARD3NL

3.03e-06261212393907
Pubmed

Chondroitin sulfate synthase-3. Molecular cloning and characterization.

CHSY1 CHSY3

3.03e-06261212907687
Pubmed

Touché! STARD3 and STARD3NL tether the ER to endosomes.

STARD3 STARD3NL

3.03e-06261227068960
Pubmed

Opposite alterations of NPFF1 and NPFF2 neuropeptide FF receptor density in the triple MOR/DOR/KOR-opioid receptor knockout mouse brains.

NPFFR2 NPFFR1

3.03e-06261215121216
Pubmed

MLN64 and MENTHO, two mediators of endosomal cholesterol transport.

STARD3 STARD3NL

3.03e-06261216709157
Pubmed

Detailed distribution of neuropeptide FF receptors (NPFF1 and NPFF2) in the rat, mouse, octodon, rabbit, guinea pig, and marmoset monkey brains: a comparative autoradiographic study.

NPFFR2 NPFFR1

3.03e-06261214696013
Pubmed

Ethanol inhibition of a T-type Ca²+ channel through activity of protein kinase C.

CACNA1I CACNA1G

9.07e-06361223488970
Pubmed

Chondroitin synthase-3 regulates nucleus pulposus degeneration through actin-induced YAP signaling.

CHSY1 CHSY3

9.07e-06361233089528
Pubmed

T-type channels: release a brake, engage a gear.

CACNA1I CACNA1G

9.07e-06361226488564
Pubmed

Differential interactions of Na+ channel toxins with T-type Ca2+ channels.

CACNA1I CACNA1G

9.07e-06361218591418
Pubmed

Identification of the t-type calcium channel (Ca(v)3.1d) in developing mouse heart.

CACNA1I CACNA1G

9.07e-06361211230107
Pubmed

Prognostic relevance of a T-type calcium channels gene signature in solid tumours: A correlation ready for clinical validation.

CACNA1I CACNA1G

9.07e-06361228846697
Pubmed

Homeostatic plasticity and burst activity are mediated by hyperpolarization-activated cation currents and T-type calcium channels in neuronal cultures.

CACNA1I CACNA1G

9.07e-06361233547341
Pubmed

Calmodulin regulates Cav3 T-type channels at their gating brake.

CACNA1I CACNA1G

9.07e-06361228972185
Pubmed

Global genetic deletion of CaV3.3 channels facilitates anaesthetic induction and enhances isoflurane-sparing effects of T-type calcium channel blockers.

CACNA1I CACNA1G

9.07e-06361233299036
Pubmed

Specific contribution of human T-type calcium channel isotypes (alpha(1G), alpha(1H) and alpha(1I)) to neuronal excitability.

CACNA1I CACNA1G

9.07e-06361211927664
Pubmed

Growth differentiation factor-15 promotes glutamate release in medial prefrontal cortex of mice through upregulation of T-type calcium channels.

CACNA1I CACNA1G

9.07e-06361227353765
Pubmed

Alpha(1H) mRNA in single skeletal muscle fibres accounts for T-type calcium current transient expression during fetal development in mice.

CACNA1I CACNA1G

9.07e-06361211897840
Pubmed

Pharmacogenetics of antiepileptic drug efficacy in childhood absence epilepsy.

CACNA1I CACNA1G

1.81e-05461228165634
Pubmed

Serotonin and Dopamine Candidate Gene Variants and Alcohol- and Non-Alcohol-Related Aggression.

SLC6A4 DRD1

1.81e-05461226041607
Pubmed

Kisspeptin regulation of arcuate neuron excitability in kisspeptin receptor knockout mice.

NPFFR2 NPFFR1

1.81e-05461225756309
Pubmed

STARD3 or STARD3NL and VAP form a novel molecular tether between late endosomes and the ER.

STARD3 STARD3NL

1.81e-05461224105263
Pubmed

Chondroitin synthases I, II, III and chondroitin sulfate glucuronyltransferase expression in colorectal cancer.

CHSY1 CHSY3

1.81e-05461221468578
Pubmed

Identification and characterization of two G protein-coupled receptors for neuropeptide FF.

NPFFR2 NPFFR1

1.81e-05461211024015
Pubmed

Effects of systematic N-terminus deletions and benzoylations of endogenous RF-amide peptides on NPFF1R, NPFF2R, GPR10, GPR54 and GPR103.

NPFFR2 NPFFR1

3.02e-05561226211894
Pubmed

Association of serotonin and dopamine gene pathways with behavioral subphenotypes in dementia.

SLC6A4 DRD1

3.02e-05561220685009
Pubmed

Complement-dependent T-cell lymphopenia caused by thymocyte deletion of the membrane complement regulator Crry.

C5 CR1

4.52e-05661219136662
Pubmed

No association between lithium full responders and the DRD1, DRD2, DRD3, DAT1, 5-HTTLPR and HTR2A genes in a Sardinian sample.

SLC6A4 DRD1

4.52e-05661219647327
Pubmed

Influence of dopaminergic and serotoninergic genes on working memory in healthy subjects.

SLC6A4 DRD1

4.52e-05661220407490
Pubmed

Beyond single-marker analyses: mining whole genome scans for insights into treatment responses in severe sepsis.

DRD1 STARD3NL

6.32e-05761222310353
Pubmed

Chondroitin sulfate N-acetylgalactosaminyltransferase-1 plays a critical role in chondroitin sulfate synthesis in cartilage.

CHSY1 CHSY3

6.32e-05761217145758
Pubmed

Mapping of the mouse Ly-6, Xp-14, and Gdc-1 loci to chromosome 15.

GPT C5

6.32e-0576122880797
Pubmed

Comorbidity between bipolar disorder and alcohol use disorder: association of dopamine and serotonin gene polymorphisms.

SLC6A4 DRD1

6.32e-05761220071033
Pubmed

Biosynthesis of chondroitin sulphate by a Golgi-apparatus-enriched preparation from cultures of mouse mastocytoma cells.

CHSY1 CHSY3

8.42e-0586126781479
Pubmed

Evolutionary insights into T-type Ca2+ channel structure, function, and ion selectivity from the Trichoplax adhaerens homologue.

CACNA1I CACNA1G

8.42e-05861228330839
Pubmed

Identification of MOSPD2, a novel scaffold for endoplasmic reticulum membrane contact sites.

STARD3 STARD3NL

8.42e-05861229858488
Pubmed

Neuroepithelial progenitors generate and propagate non-neuronal action potentials across the spinal cord.

CACNA1I CACNA1G

8.42e-05861234478646
Pubmed

Intracellular calcium plays an essential role in cardiac development.

CACNA1I CACNA1G

8.42e-05861212761855
Pubmed

The PHLPP1 N-Terminal Extension Is a Mitotic Cdk1 Substrate and Controls an Interactome Switch.

SLC4A7 ZBTB33 PLK1 COTL1 DENND4C

8.83e-0525661533397691
Pubmed

International Union of Pharmacology. XLVIII. Nomenclature and structure-function relationships of voltage-gated calcium channels.

CACNA1I CACNA1G

1.08e-04961216382099
Pubmed

Crry deficiency in complement sufficient mice: C3 consumption occurs without associated renal injury.

C5 CR1

1.08e-04961218947875
Pubmed

Association testing of panic disorder candidate genes using CCK-4 challenge in healthy volunteers.

SLC6A4 DRD1

1.08e-04961218832011
Pubmed

Insights into the ubiquitin-proteasome system of human embryonic stem cells.

EXOC5 SLC4A7 SEC23IP NUP93 BIRC6

1.11e-0426961529511261
Pubmed

Cav3.2 T-type calcium channel is required for the NFAT-dependent Sox9 expression in tracheal cartilage.

CACNA1I CACNA1G

1.35e-041061224778262
Pubmed

Deficiency of decay-accelerating factor and complement receptor 1-related gene/protein y on murine platelets leads to complement-dependent clearance by the macrophage phagocytic receptor CRIg.

C5 CR1

1.97e-041261218524992
Pubmed

Final stages of cytokinesis and midbody ring formation are controlled by BRUCE.

PLK1 BIRC6

1.97e-041261218329369
Pubmed

Postnatal lethality and chondrodysplasia in mice lacking both chondroitin sulfate N-acetylgalactosaminyltransferase-1 and -2.

CHSY1 CHSY3

1.97e-041261229287114
Pubmed

Sensory Nerve Maintains Intervertebral Disc Extracellular Matrix Homeostasis Via CGRP/CHSY1 Axis.

CHSY1 CHSY3

1.97e-041261236047655
Pubmed

TRIM8 interacts with KIF11 and KIFC1 and controls bipolar spindle formation and chromosomal stability.

PLK1 MTSS2

2.72e-041461231904480
Pubmed

The influence of serotonin- and other genes on impulsive behavioral aggression and cognitive impulsivity in children with attention-deficit/hyperactivity disorder (ADHD): Findings from a family-based association test (FBAT) analysis.

SLC6A4 DRD1

2.72e-041461218937842
Pubmed

Identification of G Protein-Coupled Receptors (GPCRs) in Primary Cilia and Their Possible Involvement in Body Weight Control.

DRD1 NPFFR1

3.13e-041561226053317
Pubmed

Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain.

TTC7A CACNA1I CACNA1G

3.29e-047661310574461
Pubmed

Conserved Mitotic Phosphorylation of a Proteasome Subunit Regulates Cell Proliferation.

SEC23IP PLK1 MTSS2

3.83e-048061334831298
Pubmed

Constitutive expression of TNF-alpha and -beta genes in mouse embryo: roles of cytokines as regulator and effector on development.

C5 CR1

6.22e-04216128138038
Pubmed

Worldwide genetic variation in dopamine and serotonin pathway genes: implications for association studies.

SLC6A4 DRD1

6.22e-042161218270970
Pubmed

Co-adaptor driven assembly of a CUL3 E3 ligase complex.

PHKB SEC23IP

6.83e-042261235120648
Pubmed

A Multipronged Unbiased Strategy Guides the Development of an Anti-EGFR/EPHA2-Bispecific Antibody for Combination Cancer Therapy.

SLC4A7 SBF1 SEC23IP FAM135A MTSS2

8.65e-0442161536976175
Pubmed

Tubby family proteins are adapters for ciliary trafficking of integral membrane proteins.

DRD1 NPFFR1

8.84e-042561228154160
Pubmed

Germline Saturation Mutagenesis Induces Skeletal Phenotypes in Mice.

CHSY1 CHSY3

9.57e-042661233905568
Pubmed

Osteocyte transcriptome mapping identifies a molecular landscape controlling skeletal homeostasis and susceptibility to skeletal disease.

SKIDA1 MTSS2

1.11e-032861233953184
Pubmed

Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk.

SLC4A7 SH2B3

1.19e-032961221909115
Pubmed

Characterization of the endogenous nonecotropic murine leukemia viruses of NZB/B1NJ and SM/J inbred strains.

GPT C5

1.28e-03306121311971
Pubmed

A mouse knockout library for secreted and transmembrane proteins.

CLEC4E SIGLEC7 CHSY1 IFNE STARD3NL

1.28e-0346061520562862
Pubmed

Risk of non-Hodgkin lymphoma in association with germline variation in complement genes.

C5 CR1

1.36e-033161219344414
Pubmed

The NXSM recombinant inbred strains of mice: genetic profile for 58 loci including the Mtv proviral loci.

GPT C5

1.36e-03316122165966
Pubmed

Integral and associated lysosomal membrane proteins.

SLC36A1 STARD3 STARD3NL

1.43e-0312661317897319
Pubmed

A BioID-Derived Proximity Interactome for SARS-CoV-2 Proteins.

SEC23IP STARD3 BIRC6 FAM135A ALG12 DENND4C

1.62e-0371961635337019
GeneFamilyNeuropeptide receptors

NPFFR2 NPFFR1

2.46e-0410432854
GeneFamilyDyneins, axonemal

DNAH2 DNAH14

7.35e-0417432536
GeneFamilyBeta 4-glycosyltransferases

CHSY1 CHSY3

7.35e-0417432425
GeneFamilyG protein-coupled receptors, Class A orphans

GPR27 GPR55 GPR87

8.42e-0478433262
GeneFamilyBeta 3-glycosyltransferases

CHSY1 CHSY3

1.48e-0324432426
GeneFamilyGuanylate cyclase receptors|DENN/MADD domain containing

SBF1 DENND4C

1.60e-0325432504
GeneFamilyCalcium voltage-gated channel subunits

CACNA1I CACNA1G

1.73e-0326432253
GeneFamilyComplement system|Sushi domain containing

C5 CR1

3.31e-0336432492
GeneFamilySolute carriers

SLC6A4 SLC36A1 SLC4A7 SLC15A5

1.42e-02395434752
ToppCellTCGA-Breast-Primary_Tumor-Breast_Carcinoma-Infiltrating_Ductal_Carcinoma-4|TCGA-Breast / Sample_Type by Project: Shred V9

TTC7A GPR55 NUP93 NPFFR1 COTL1

4.20e-0617860544b5ba4e8788d3973749a1717e427647ac4c8579
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-TAM-MG-TAM-MG_pro-infl_II-F|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

SH2B3 RASGEF1C CHSY1 IFNE ASTL

6.87e-06197605b597c292fc1cb381a4325fed15a32966c38def28
DiseaseRecurrent depression

SLC6A4 DRD1

1.31e-049572C0221480
Diseasedepressive disorder (implicated_via_orthology)

SLC6A4 DRD1

8.26e-0422572DOID:1596 (implicated_via_orthology)
Diseaseeosinophil measurement

SLC36A1 EFHC1 SH2B3

1.21e-03108573EFO_0803540
DiseaseC-X-C motif chemokine 10 measurement

NPFFR2 SH2B3 PLSCR5

1.24e-03109573EFO_0008056
Diseasenon-alcoholic fatty liver disease severity measurement

DRD1 DNASE1

1.34e-0328572EFO_0008421
Diseasevitamin D-binding protein measurement

NPFFR2 SH2B3

2.21e-0336572EFO_0005675
Diseasevitamin D deficiency

NPFFR2 NADSYN1

2.34e-0337572EFO_0003762
Diseaseliver cirrhosis (is_implicated_in)

SLC6A4 C5

3.15e-0343572DOID:5082 (is_implicated_in)
Diseasepotassium measurement

SLC4A7 NUP93

3.44e-0345572EFO_0009283
Diseasecryptic phenotype measurement

SLC4A7 SH2B3

3.75e-0347572EFO_0021487
Diseasesystolic blood pressure, alcohol consumption measurement

SLC4A7 SH2B3

3.75e-0347572EFO_0006335, EFO_0007878

Protein segments in the cluster

PeptideGeneStartEntry
TRECIEAVIRFAFEE

GPT

251

P24298
TRKFLSDIVRVCFFE

BIRC6

1381

Q9NR09
VERDFSVRILTACFL

DRD1

16

P21728
AEQRTVFAFVLCLLV

CTXN1

26

P60606
QRLCDTLFVIFSAVF

CERS5

266

Q8N5B7
TCIRFVTYQDQRDFI

ASTL

131

Q6HA08
SAFAIIVFRVELCLF

ALG12

176

Q9BV10
FLRCVSELVIESREF

NUP93

566

Q8N1F7
FTLVAIAVDRFQCVV

NPFFR2

236

Q9Y5X5
VFTLVAIAVERFRCI

NPFFR1

131

Q9GZQ6
FCDVTVIVEDRKFRA

ZBTB33

31

Q86T24
EVFDRFTVVLHIFRC

GTPBP6

196

O43824
TLRVRRFSEAFFCFE

FAM135A

341

Q9P2D6
VVCFLFNRELRDCFR

GPR27

336

Q9NS67
QRIYFAVEESICFNR

PLSCR5

96

A0PG75
IEERGRFCTFITFLQ

MTSS2

191

Q765P7
FFLQFLVRNSFIVEC

GPR55

246

Q9Y2T6
NQSIRVVVAVFFTCF

GPR87

251

Q9BY21
VVRFQVDENIRAFCA

ITFG2

341

Q969R8
AVVRFINRFVDKVCT

SBF1

826

O95248
AFFDRCRTSEVVEIQ

HSPBAP1

331

Q96EW2
RNAFRIFTILVEFLC

EXOC5

441

O00471
QCTDDVRLFAFVRFT

COTL1

51

Q14019
SQRCRILQAFDDFIF

CACNA1G

111

O43497
RSFFSLTEIIRFRCQ

CR1

1606

P17927
RTFVGCAVREFTFLA

GPHB5

31

Q86YW7
AIVRFFSRFTEVREF

DNASE1

136

P24855
RCKILQVFDDFIFIF

CACNA1I

111

Q9P0X4
DFLCVRFRIFELFEV

C5

1471

P01031
KTQIFIRFIEECSFV

DENND4C

621

Q5VZ89
VVITLCRILDAFFDF

DNAH14

1696

Q0VDD8
FRVVDCDQFTQVFLE

EFHC1

181

Q5JVL4
RQDRVAFCVTSFIIT

DNAH2

3796

Q9P225
LLLVELCERFTFFEV

SLC15A5

46

A6NIM6
AIVQVEISRCLFFVF

IFNE

166

Q86WN2
FIQNLVFCVERVYRV

PHKB

201

Q93100
RFTEEAFAALICIIF

SLC4A7

721

Q9Y6M7
FEFFENTIVSRIARI

SEMA4B

271

Q9NPR2
CFAEIRNDRVSEITF

SKIDA1

541

Q1XH10
RFDVQVCSRQIYFVA

SPPL2C

461

Q8IUH8
FLSFCVIFIVVRSCR

SIGLEC7

366

Q9Y286
FRSIIECVDDFRVVS

SEC23IP

461

Q9Y6Y8
TCRQELQVLFFVVFL

OR5M9

16

Q8NGP3
ISDVRRTFCLFVTFD

STARD3

46

Q14849
DVDLVFTTEFLQRCR

CHSY1

631

Q86X52
FCDVDLIFREDFLQR

CHSY3

716

Q70JA7
ACFITRCVVTFRIFQ

CLEC4E

36

Q9ULY5
FIEVQAFCIEFSRIR

CNOT11

471

Q9UKZ1
FLFFICVRGHVTERQ

NEU3

101

Q9UQ49
RRRTVEDFNKFCTFV

PHF13

21

Q86YI8
VVVFSSRQLARVFFE

TAS1R1

271

Q7RTX1
RVVDFFLIVTQLGFC

SLC36A1

141

Q7Z2H8
VRRTFCLFVTFDLLF

STARD3NL

51

O95772
AQVIEFFIDVARECF

RASGEF1C

276

Q8N431
VVCFSDFEARQLLRV

RNF44

381

Q7L0R7
QFTDLFQRYFCREVR

SH2B3

66

Q9UQQ2
RFRLTEREEEVITCF

TTC7A

186

Q9ULT0
RRERFVLAVVITCFF

SLC6A4

461

P31645
CVERFIDTSQFILNR

TIMM8A

66

O60220
EDNDFVFVVLELCRR

PLK1

121

P53350
DLRAFVQFCIQRFQL

NADSYN1

546

Q6IA69