Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	CP2	TFCP2L1 TFCP2	1.13e-04	6	52	2	PF04516
Domain	CP2	TFCP2L1 TFCP2	1.13e-04	6	52	2	IPR007604
Domain	ARM-like	RELCH ARFGEF2 PUM3 HEATR1 HUWE1	9.08e-04	270	52	5	IPR011989
Domain	ARM-type_fold	RELCH ARFGEF2 PUM3 HEATR1 HUWE1	2.47e-03	339	52	5	IPR016024
Domain	-	RELCH ARFGEF2 PUM3 HEATR1	3.37e-03	222	52	4	1.25.10.10
Pubmed	Modulation of CP2 family transcriptional activity by CRTR-1 and sumoylation.	TFCP2L1 TFCP2	2.37e-06	2	54	2	20661472
Pubmed	CRTR-1, a developmentally regulated transcriptional repressor related to the CP2 family of transcription factors.	TFCP2L1 TFCP2	2.37e-06	2	54	2	11073954
Pubmed	Interaction of Mint3 with Furin regulates the localization of Furin in the trans-Golgi network.	FURIN APBA3	2.37e-06	2	54	2	18544638
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	ARHGAP5 RELCH COX4I1 ZNF280C CRYBG3 HUWE1 PAAF1 CDC25C PPEF1 KNL1	4.28e-06	1049	54	10	27880917
Pubmed	TFCP2/TFCP2L1/UBP1 transcription factors in cancer.	TFCP2L1 TFCP2	7.09e-06	3	54	2	29410248
Pubmed	Regulatory pathway analysis by high-throughput in situ hybridization.	ARHGAP5 WNT2B ADCY8 CHRNB4	1.25e-05	91	54	4	17953485
Pubmed	Transferrin receptor 2 and HFE regulate furin expression via mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/Erk) signaling. Implications for transferrin-dependent hepcidin regulation.	HFE FURIN	2.36e-05	5	54	2	20634490
Pubmed	Identification and characterization of Grainyhead-like epithelial transactivator (GET-1), a novel mammalian Grainyhead-like factor.	TFCP2L1 TFCP2	3.54e-05	6	54	2	12666198
Pubmed	Mapping of the mouse Ly-6, Xp-14, and Gdc-1 loci to chromosome 15.	ADAMTS20 C5	4.94e-05	7	54	2	2880797
Pubmed	Gene trap screening as an effective approach for identification of Wnt-responsive genes in the mouse embryo.	TFCP2L1 WNT2B	1.55e-04	12	54	2	15778975
Pubmed	TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.	TRAPPC11 HUS1 GYS1 C5 FER1L6 KNL1	4.55e-04	638	54	6	31182584
Pubmed	Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	SLMAP HUWE1 KNL1	5.29e-04	101	54	3	10997877
Pubmed	Discovery of six new susceptibility loci and analysis of pleiotropic effects in leprosy.	COX4I1 IL18R1	5.36e-04	22	54	2	25642632
Pubmed	Gata2, Nkx2-2 and Skor2 form a transcription factor network regulating development of a midbrain GABAergic neuron subtype with characteristics of REM-sleep regulatory neurons.	PTCHD4 HCRTR1	5.86e-04	23	54	2	35815619
Pubmed	Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk.	HFE FURIN	9.35e-04	29	54	2	21909115
Pubmed	VCP phosphorylation-dependent interaction partners prevent apoptosis in Helicobacter pylori-infected gastric epithelial cells.	RELCH ARFGEF2 HEATR1 HUWE1	1.05e-03	288	54	4	23383273
Pubmed	The E3 ubiquitin ligases, HUWE1 and NEDD4-1, are involved in the post-translational regulation of the ABCG1 and ABCG4 lipid transporters.	GYS1 HUWE1	1.21e-03	33	54	2	26296893
Pubmed	Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes.	HUS1 CDC25C	1.29e-03	34	54	2	12791985
Disease	Withdrawal Symptoms	ADCY8 HCRTR1 CHRNB4	1.17e-04	58	48	3	C0087169
Disease	Drug Withdrawal Symptoms	ADCY8 HCRTR1 CHRNB4	1.17e-04	58	48	3	C0086189
Disease	Substance Withdrawal Syndrome	ADCY8 HCRTR1 CHRNB4	1.17e-04	58	48	3	C0038587
Disease	chronic kidney disease	TFCP2L1 ECM2 MARCHF1 ADCY8	5.80e-04	235	48	4	EFO_0003884
Disease	Antihypertensive use measurement	HFE FURIN WNT2B ADCY8	9.07e-04	265	48	4	EFO_0009927
Disease	hypertension	HFE FURIN WNT2B MARCHF1	1.56e-03	307	48	4	EFO_0000537
Disease	attention function measurement	HEATR1 ADCY8 CHRNB4	1.81e-03	148	48	3	EFO_0007636
Disease	Ischemic stroke	TRAPPC11 FURIN WNT2B MARCHF1	1.90e-03	324	48	4	HP_0002140
Disease	liver cirrhosis (is_implicated_in)	HFE C5	2.24e-03	43	48	2	DOID:5082 (is_implicated_in)
Disease	potassium measurement	TFCP2L1 WNT2B	2.45e-03	45	48	2	EFO_0009283
Disease	acute lymphoblastic leukemia (is_implicated_in)	HFE ERCC1	3.64e-03	55	48	2	DOID:9952 (is_implicated_in)
Disease	multiple myeloma (is_implicated_in)	HFE ERCC1	4.18e-03	59	48	2	DOID:9538 (is_implicated_in)

Protein segments in the cluster

Peptide	Gene	Start	Entry
LCSHRVTHTVQKVEA	UMODL1	36	Q5DID0
VTFSIVTSVCVLNVH	CHRNB4	306	P30926
ICALVVVRKDTTSHT	ADCY8	226	P40145
VREELKFKHTVSTCQ	CRYBG3	1211	Q68DQ2
VTFYCTTKDVNITIH	CEACAM20	86	Q6UY09
VELAFQTTCHIVTTI	ARFGEF2	1241	Q9Y6D5
ETKSQTSVTLSIVHC	APBA3	466	O96018
SFTTCKEIQVKNHIR	ADAMTS20	1711	P59510
TVVLAQCTVEKVHTF	CPNE6	281	O95741
KTIAFAHDSTRVIQC	PUM3	171	Q15397
KINVTSTACVHEFSR	RELCH	846	Q9P260
KHSCFTERQVTSKIV	IL18R1	116	Q13478
FVSRVTECLTTVKSV	ERCC1	231	P07992
THSVIEKTFRTLCSR	HARBI1	256	Q96MB7
EITRSHTTALECKTV	KNL1	941	Q8NG31
EAQVHTIRILTCQKT	GOLGA6L1	126	Q8N7Z2
KVTHHVTSSVTTLRC	HFE	211	Q30201
KKVFSTCSAHLTVVI	OR2S2	236	Q9NQN1
CVSVVKVSIVNHLEF	HUWE1	2666	Q7Z6Z7
RKKAFSTCSSHVIVV	OR6C76	231	A6NM76
ERRKIFCSVTFHVIA	MARCHF1	151	Q8TCQ1
DTQKRIIIVFHCEFS	CDC25C	366	P30307
TFSRIHTKSITCLDI	PAAF1	86	Q9BRP4
CSISKISEHVVLTSV	HCRTR1	406	O43613
STFIFVCVAHEISQI	CASD1	741	Q96PB1
HRVCTYNETKQVTVK	GPHB5	81	Q86YW7
IVTTDLRQKCTESHT	FURIN	351	P09958
VTTVVHKTSTSEEVC	C5	1361	P01031
TSVIRAHKSVTECAV	DIP2C	1461	Q9Y2E4
TEICFNHTRKINVIV	ECM2	501	O94769
KVTFHVILSVLVSCC	HEATR1	701	Q9H583
CAHVFTTVSQITAIE	GYS1	251	P13807
ITSATSVIHKDQCFV	FDXACB1	471	Q9BRP7
STSVCVRAHESVVKS	COX4I1	16	P13073
TAEVKHNITNTVVCR	OSBPL11	616	Q9BXB4
FTHIQTSPSKEVTIC	PPEF1	156	O14829
KAFSTCVSHLIIVTV	OR10K2	236	Q6IF99
QRKALSTCAFHITVV	OR4C5	246	Q8NGB2
AKVTFLSHCQTTKII	FER1L6	851	Q2WGJ9
TCHQIQSIEDFTKVV	SLC9C1	1076	Q4G0N8
SESIVCVHFLISQVE	HIF3A	331	Q9Y2N7
NLKIETELVCVTTHF	HUS1	191	O60921
SECHVELSQSTKRVV	GPR182	41	O15218
VVCTKTDFIITASHD	PPWD1	96	Q96BP3
FVLATEHTRTQCIKS	PTCHD4	736	Q6ZW05
AICRQTTSHKEISYV	SHPRH	1476	Q149N8
TKIHQSVVETFIQQC	ARHGAP5	1431	Q13017
KRASAFIQVHCISTE	TFCP2L1	161	Q9NZI6
HEVCFRQVTKTTSEK	ZFP30	121	Q9Y2G7
CLVVTVQSHEKTQIR	TRAPPC11	771	Q7Z392
KRTSVFIQVHCISTE	TFCP2	181	Q12800
ENTRKVTHGCIVSTI	SLMAP	111	Q14BN4
THTCQVIIENVSKST	ZNF280C	711	Q8ND82
TTRVTRVTQCECKFH	WNT2B	346	Q93097