Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	ubiquitin-like ligase-substrate adaptor activity	PRAMEF5 SKP2 PRAMEF27 PRAMEF6	3.46e-05	82	45	4	GO:1990756
GeneOntologyMolecularFunction	RNA polymerase II-specific DNA-binding transcription factor binding	ZBTB8A TBX3 PPARA PRAMEF5 ASAH1 PRAMEF27 PRAMEF6	3.77e-05	417	45	7	GO:0061629
GeneOntologyMolecularFunction	enzyme-substrate adaptor activity	PRAMEF5 SKP2 PRAMEF27 PRAMEF6	6.17e-05	95	45	4	GO:0140767
GeneOntologyMolecularFunction	MAP kinase tyrosine phosphatase activity	DUSP16 DUSP8	2.21e-04	10	45	2	GO:0033550
GeneOntologyMolecularFunction	nuclear retinoic acid receptor binding	PRAMEF5 PRAMEF27 PRAMEF6	2.59e-04	55	45	3	GO:0042974
GeneOntologyMolecularFunction	protein tyrosine/threonine phosphatase activity	DUSP16 DUSP8	2.70e-04	11	45	2	GO:0008330
GeneOntologyMolecularFunction	DNA-binding transcription factor binding	ZBTB8A TBX3 PPARA PRAMEF5 ASAH1 PRAMEF27 PRAMEF6	2.99e-04	582	45	7	GO:0140297
GeneOntologyMolecularFunction	MAP kinase tyrosine/serine/threonine phosphatase activity	DUSP16 DUSP8	3.81e-04	13	45	2	GO:0017017
GeneOntologyMolecularFunction	MAP kinase phosphatase activity	DUSP16 DUSP8	7.43e-04	18	45	2	GO:0033549
GeneOntologyMolecularFunction	nuclear receptor binding	PRAMEF5 ASAH1 PRAMEF27 PRAMEF6	8.22e-04	187	45	4	GO:0016922
GeneOntologyMolecularFunction	phosphotransferase activity, alcohol group as acceptor	PIKFYVE TYRO3 AGK PANK3 PDK1 CDK4 UHMK1	9.67e-04	709	45	7	GO:0016773
GeneOntologyMolecularFunction	transcription factor binding	ZBTB8A TBX3 PPARA PRAMEF5 ASAH1 PRAMEF27 PRAMEF6	1.37e-03	753	45	7	GO:0008134
GeneOntologyMolecularFunction	kinase activity	PIKFYVE TYRO3 AGK PANK3 PDK1 CDK4 UHMK1	1.49e-03	764	45	7	GO:0016301
GeneOntologyMolecularFunction	lipid kinase activity	PIKFYVE AGK	3.85e-03	41	45	2	GO:0001727
GeneOntologyMolecularFunction	protein tyrosine/serine/threonine phosphatase activity	DUSP16 DUSP8	4.23e-03	43	45	2	GO:0008138
GeneOntologyMolecularFunction	transferase activity, transferring phosphorus-containing groups	PIKFYVE TYRO3 AGK PANK3 PDK1 CDK4 UHMK1	4.70e-03	938	45	7	GO:0016772
GeneOntologyMolecularFunction	transcription coactivator binding	ZBTB8A PPARA	6.60e-03	54	45	2	GO:0001223
GeneOntologyCellularComponent	Cul2-RING ubiquitin ligase complex	PRAMEF5 PRAMEF27 PRAMEF6	1.32e-04	47	44	3	GO:0031462
MousePheno	abnormal sex determination	TYRO3 M1AP PRAMEF5 BCO2 PDK1 ASAH1 PRAMEF27 CCDC157 PRAMEF6 CDK4	7.36e-05	945	35	10	MP:0002210
MousePheno	increased chromosomal stability	ZSCAN5A ZSCAN5C	9.08e-05	6	35	2	MP:0010095
MousePheno	abnormal spermatogonia proliferation	PRAMEF5 PRAMEF27 PRAMEF6	2.16e-04	47	35	3	MP:0002685
MousePheno	small gonad	TYRO3 M1AP PRAMEF5 BCO2 PDK1 ASAH1 PRAMEF27 PRAMEF6 CDK4	2.48e-04	885	35	9	MP:0001116
MousePheno	decreased testis weight	M1AP PRAMEF5 BCO2 PRAMEF27 PRAMEF6 CDK4	2.80e-04	370	35	6	MP:0004852
MousePheno	abnormal primary sex determination	TYRO3 M1AP PRAMEF5 BCO2 PDK1 ASAH1 PRAMEF27 PRAMEF6 CDK4	2.84e-04	901	35	9	MP:0002211
Domain	PRAME_family	PRAMEF5 PRAMEF27 PRAMEF6	1.15e-05	19	44	3	IPR026271
Domain	MKP	DUSP16 DUSP8	2.41e-04	10	44	2	IPR008343
Domain	RHOD	DUSP16 DUSP8	1.22e-03	22	44	2	SM00450
Domain	RHODANESE_3	DUSP16 DUSP8	1.33e-03	23	44	2	PS50206
Domain	zf-CCHC	ZCCHC14 DDX41	1.33e-03	23	44	2	PF00098
Domain	Rhodanese-like_dom	DUSP16 DUSP8	1.45e-03	24	44	2	IPR001763
Domain	-	DUSP16 DUSP8	1.45e-03	24	44	2	3.40.250.10
Domain	Rhodanese	DUSP16 DUSP8	1.45e-03	24	44	2	PF00581
Domain	DUSP	DUSP16 DUSP8	2.42e-03	31	44	2	IPR024950
Domain	TYR_PHOSPHATASE_DUAL	DUSP16 DUSP8	2.90e-03	34	44	2	PS50054
Domain	ZF_CCHC	ZCCHC14 DDX41	3.07e-03	35	44	2	PS50158
Domain	DSPc	DUSP16 DUSP8	3.07e-03	35	44	2	SM00195
Domain	TYR_PHOSPHATASE_DUAL_dom	DUSP16 DUSP8	3.07e-03	35	44	2	IPR020422
Domain	Dual-sp_phosphatase_cat-dom	DUSP16 DUSP8	4.20e-03	41	44	2	IPR000340
Domain	DSPc	DUSP16 DUSP8	4.20e-03	41	44	2	PF00782
Domain	-	PRAMEF5 SKP2 PRAMEF27 PRAMEF6	6.77e-03	321	44	4	3.80.10.10
Domain	L_dom-like	PRAMEF5 SKP2 PRAMEF27 PRAMEF6	7.30e-03	328	44	4	IPR032675
Domain	ZnF_C2HC	ZCCHC14 DDX41	7.44e-03	55	44	2	SM00343
Domain	Znf_CCHC	ZCCHC14 DDX41	7.44e-03	55	44	2	IPR001878
Domain	SCAN	ZSCAN5A ZSCAN5C	7.71e-03	56	44	2	SM00431
Domain	SCAN_BOX	ZSCAN5A ZSCAN5C	8.25e-03	58	44	2	PS50804
Domain	SCAN	ZSCAN5A ZSCAN5C	8.25e-03	58	44	2	PF02023
Domain	SCAN_dom	ZSCAN5A ZSCAN5C	8.25e-03	58	44	2	IPR003309
Domain	Retrov_capsid_C	ZSCAN5A ZSCAN5C	8.52e-03	59	44	2	IPR008916
Pathway	KEGG_MEDICUS_PATHOGEN_HCV_CORE_TO_RXRA_PPARA_MEDIATED_TRANSCRIPTION	PPARA CDK4	3.79e-05	5	28	2	M49012
Pathway	REACTOME_SIGNALING_BY_MAPK_MUTANTS	DUSP16 DUSP8	7.94e-05	7	28	2	M38997
Pubmed	Transcriptome analysis of mouse stem cells and early embryos.	PRAMEF5 FAM193A DOCK11 ZSCAN5A PRAMEF6 ZSCAN5C DUSP16	4.80e-07	363	46	7	14691545
Pubmed	ZAR1 and ZAR2 are required for oocyte meiotic maturation by regulating the maternal transcriptome and mRNA translational activation.	PRAMEF5 ZSCAN5A PRAMEF6 ZSCAN5C	1.08e-06	58	46	4	31598710
Pubmed	Preferentially Expressed Antigen in Melanoma (PRAME) and the PRAME Family of Leucine-Rich Repeat Proteins.	PRAMEF5 PRAMEF27 PRAMEF6	2.43e-06	20	46	3	26694250
Pubmed	Sertoli cell-only phenotype and scRNA-seq define PRAMEF12 as a factor essential for spermatogenesis in mice.	PRAMEF5 PRAMEF27 PRAMEF6	3.28e-06	22	46	3	31729367
Pubmed	MAGE-B4, a binding partner of PRAMEF12, is dispensable for spermatogenesis and male fertility in mice.	PRAMEF5 PRAMEF27 PRAMEF6	4.88e-06	25	46	3	37451217
Pubmed	Serum starvation induces G1 arrest through suppression of Skp2-CDK2 and CDK4 in SK-OV-3 cells.	SKP2 CDK4	5.13e-06	3	46	2	18202766
Pubmed	Expression profiling in transgenic FVB/N embryonic stem cells overexpressing STAT3.	PRAMEF5 SKP2 PRAMEF6	5.51e-06	26	46	3	18500982
Pubmed	Differences in gene expression between mouse and human for dynamically regulated genes in early embryo.	PRAMEF5 PRAMEF27 PRAMEF6	6.93e-06	28	46	3	25089626
Pubmed	Zscan5b Deficiency Impairs DNA Damage Response and Causes Chromosomal Aberrations during Mitosis.	ZSCAN5A ZSCAN5C	1.03e-05	4	46	2	31155506
Pubmed	ZSCAN5B and primate-specific paralogs bind RNA polymerase III genes and extra-TFIIIC (ETC) sites to modulate mitotic progression.	ZSCAN5A ZSCAN5C	1.03e-05	4	46	2	27732952
Pubmed	The steady-state level of CDK4 protein is regulated by antagonistic actions between PAQR4 and SKP2 and involved in tumorigenesis.	SKP2 CDK4	1.03e-05	4	46	2	28992327
Pubmed	Retinoic acid receptors are required for skeletal growth, matrix homeostasis and growth plate function in postnatal mouse.	PRAMEF5 PRAMEF27 PRAMEF6	1.38e-05	35	46	3	19389355
Pubmed	Regulation of Sp1 by cell cycle related proteins.	SKP2 CDK4	1.71e-05	5	46	2	18769160
Pubmed	The control operated by the cell cycle machinery on MEF2 stability contributes to the downregulation of CDKN1A and entry into S phase.	SKP2 CDK4	1.71e-05	5	46	2	25733682
Pubmed	Identification of cellular proteins interacting with the retroviral restriction factor SAMHD1.	SAMHD1 SKP2	2.56e-05	6	46	2	24623419
Pubmed	USP18 (UBP43) Abrogates p21-Mediated Inhibition of HIV-1.	SAMHD1 SKP2	2.56e-05	6	46	2	30068654
Pubmed	Cyclin-dependent kinases phosphorylate human Cdt1 and induce its degradation.	SKP2 CDK4	2.56e-05	6	46	2	15004027
Pubmed	Notch1 modulates timing of G1-S progression by inducing SKP2 transcription and p27 Kip1 degradation.	SKP2 CDK4	3.58e-05	7	46	2	15998794
Pubmed	A Multidimensional Characterization of E3 Ubiquitin Ligase and Substrate Interaction Network.	SKP2 CDK4	6.12e-05	9	46	2	31181401
Pubmed	Pocket proteins critically regulate cell cycle exit of the trabecular myocardium and the ventricular conduction system.	TBX3 CDK4	2.03e-04	16	46	2	24143284
Pubmed	Differential expression of PRAMEL1, a cancer/testis antigen, during spermatogenesis in the mouse.	PRAMEF5 PRAMEF6	2.30e-04	17	46	2	23565261
Pubmed	Mouse Pramel1 regulates spermatogonial development by inhibiting retinoic acid signaling during spermatogenesis.	PRAMEF5 PRAMEF6	2.30e-04	17	46	2	37781892
Pubmed	Oocyte-specific gene Oog1 suppresses the expression of spermatogenesis-specific genes in oocytes.	PRAMEF5 PRAMEF6	2.58e-04	18	46	2	29731491
Pubmed	The promoter of the oocyte-specific gene, Oog1, functions in both male and female meiotic germ cells in transgenic mice.	PRAMEF5 PRAMEF6	2.58e-04	18	46	2	23894331
Pubmed	Identification of a new expanding family of genes characterized by atypical LRR domains. Localization of a cluster preferentially expressed in oocyte.	PRAMEF5 PRAMEF6	2.58e-04	18	46	2	14675769
Pubmed	Oogenesin is a novel mouse protein expressed in oocytes and early cleavage-stage embryos.	PRAMEF5 PRAMEF6	2.58e-04	18	46	2	12890732
Pubmed	Pramel15 facilitates zygotic nuclear DNMT1 degradation and DNA demethylation.	PRAMEF5 PRAMEF6	2.58e-04	18	46	2	39181896
Pubmed	Pramel7 mediates ground-state pluripotency through proteasomal-epigenetic combined pathways.	PRAMEF5 PRAMEF6	2.88e-04	19	46	2	28604677
Pubmed	Oog1, an oocyte-specific protein, interacts with Ras and Ras-signaling proteins during early embryogenesis.	PRAMEF5 PRAMEF6	3.20e-04	20	46	2	16580637
Pubmed	Pramel7 mediates LIF/STAT3-dependent self-renewal in embryonic stem cells.	PRAMEF5 PRAMEF6	3.20e-04	20	46	2	21425410
Pubmed	The DNA sequence and biological annotation of human chromosome 1.	ZBTB8A PRAMEF5 INTS3 SH2D5 RGS13 PRAMEF6 UHMK1	3.85e-04	1031	46	7	16710414
Pubmed	Oogenesis specific genes (Nobox, Oct4, Bmp15, Gdf9, Oogenesin1 and Oogenesin2) are differentially expressed during natural and gonadotropin-induced mouse follicular development.	PRAMEF5 PRAMEF6	4.25e-04	23	46	2	19480014
Pubmed	Incomplete reactivation of Oct4-related genes in mouse embryos cloned from somatic nuclei.	PRAMEF5 PRAMEF6	5.04e-04	25	46	2	12620990
Pubmed	Murine craniofacial development requires Hdac3-mediated repression of Msx gene expression.	TBX3 CDK4	5.45e-04	26	46	2	23506836
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	PIKFYVE ZCCHC14 PPARA UBE3C CHPF SGSM2 DUSP16	5.81e-04	1105	46	7	35748872
Pubmed	Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.	ZCCHC14 ZBTB8A TBX3 PPARA ZSCAN5A ZSCAN5C	6.55e-04	808	46	6	20412781
Pubmed	Thirteen Ovary-Enriched Genes Are Individually Not Essential for Female Fertility in Mice.	PRAMEF5 PRAMEF6	7.27e-04	30	46	2	38786026
Pubmed	CRL4AMBRA1 is a master regulator of D-type cyclins.	SKP2 CDK4	7.27e-04	30	46	2	33854235
Pubmed	NLRP14 deficiency causes female infertility with oocyte maturation defects and early embryonic arrest by impairing cytoplasmic UHRF1 abundance.	ZSCAN5A ZSCAN5C	8.28e-04	32	46	2	38060382
Pubmed	LSM14B is essential for oocyte meiotic maturation by regulating maternal mRNA storage and clearance.	PRAMEF5 PRAMEF6	8.28e-04	32	46	2	37889087
Pubmed	rec-YnH enables simultaneous many-by-many detection of direct protein-protein and protein-RNA interactions.	SLAIN1 DDX41 CDK4	8.89e-04	142	46	3	30217970
Pubmed	Cracking the egg: molecular dynamics and evolutionary aspects of the transition from the fully grown oocyte to embryo.	SAMHD1 PRAMEF5 STX5 PRAMEF6	9.07e-04	326	46	4	17015433
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	ZCCHC14 STX5 PANK3 DDX41 ARHGEF17 DOCK11	9.11e-04	861	46	6	36931259
Pubmed	Reduced lifespan of mice lacking catalase correlates with altered lipid metabolism without oxidative damage or premature aging.	MAP1LC3A PPARA	9.90e-04	35	46	2	30818059
Pubmed	Hearts of hypoxia-inducible factor prolyl 4-hydroxylase-2 hypomorphic mice show protection against acute ischemia-reperfusion injury.	PPARA PDK1	1.17e-03	38	46	2	20185832
Pubmed	Cell cycle genes and ovarian cancer susceptibility: a tagSNP analysis.	SKP2 CDK4	1.23e-03	39	46	2	19738611
GeneFamily	PRAME family	PRAMEF5 PRAMEF27 PRAMEF6	9.02e-06	24	31	3	686
GeneFamily	MAP kinase phosphatases	DUSP16 DUSP8	1.55e-04	11	31	2	895
Disease	tumor necrosis factor receptor superfamily member 19L measurement	PIKFYVE ARHGEF17	5.25e-05	8	41	2	EFO_0008309
Disease	glioblastoma (is_implicated_in)	MAP1LC3A CDK4	5.10e-04	24	41	2	DOID:3068 (is_implicated_in)
Disease	Malignant Neoplasms	PPARA SKP2 CDK4	7.53e-04	128	41	3	C0006826
Disease	cervix uteri carcinoma in situ (is_marker_for)	SKP2 CDK4	1.57e-03	42	41	2	DOID:8991 (is_marker_for)
Disease	Acute Cerebrovascular Accidents	ZCCHC14 TBX3	2.58e-03	54	41	2	C0751956
Disease	Cerebrovascular accident	ZCCHC14 TBX3	3.38e-03	62	41	2	C0038454
Disease	transitional cell carcinoma (is_marker_for)	SKP2 CDK4	3.49e-03	63	41	2	DOID:2671 (is_marker_for)
Disease	Benign Neoplasm	PPARA SKP2	4.05e-03	68	41	2	C0086692
Disease	Neoplasms	PPARA SKP2	4.05e-03	68	41	2	C0027651

Protein segments in the cluster

Peptide	Gene	Start	Entry
FFCDPRKREQMLTSP	AGK	406	Q53H12
RGCIMNTFRVPAEKF	ADAM21	361	Q9UKJ8
EPAPETQFKRRSCQM	DUSP8	576	Q13202
EIFMTEDPSKCSPRF	ARMH3	31	Q5T2E6
HPFFLDDRRTPAKMC	ASAH1	326	Q13510
PDPCKNVFERFMSRF	BCO2	151	Q9BYV7
RFPSWKFPDRMACDL	CCDC157	36	Q569K6
KRFRPSKMSCRESAP	DMXL1	2391	Q9Y485
PSKDCPKLDMLTRNF	FAM193A	941	P78312
LRAMLREKFPEFCSS	INTS3	486	Q68E01
CVPSREPKDMTTFRS	PDK1	421	Q15118
KMCRVFKRPFSEPSA	ANO10	536	Q9NW15
SFTCSEKPMARRLPR	ARHGEF17	546	Q96PE2
FSNISRPRDNPMCLK	M1AP	246	Q8TC57
SRRMCFTSKSFRPEP	ATXN8OS	96	P0DMR3
CMPDRYQFNSRKPIT	IFI44L	286	Q53G44
PVTMSFPFCRSREIN	OR2T35	161	Q8NGX2
MFCLEQEKRLPFSKR	DDX41	241	Q9UJV9
ASEPERCQKMPFNLD	PANK3	166	Q9H999
TFREPFLLTEKGMRC	PIKFYVE	1061	Q9Y2I7
DFSGDFRMLPCKSLR	DOCK11	121	Q5JSL3
EMFRRKPLFCGNSEA	CDK4	206	P11802
ESPFEKQFKRRSCQM	DUSP16	616	Q9BY84
MCRDESKRPPSNLTL	RGS13	11	O14921
SLRKPFCDIMEPKFD	PPARA	346	Q07869
TKSGRRMFPPFKVRC	TBX3	126	O15119
MQRADSEQPSKRPRC	SAMHD1	1	Q9Y3Z3
FMARNPRSPASKLFC	SH2D5	106	Q6ZV89
FTPPNLERLRDVMCS	SGSM2	811	O43147
PTPEMEAARRSLCFR	SLAIN1	216	Q8ND83
ELFPPLFMEAFSRRC	PRAMEF27	36	A3QJZ7
MPSDRPFKQRRSFAD	MAP1LC3A	1	Q9H492
PPDTMSCRDRTQEFL	STX5	51	Q13190
PDTVLTPDFLNRCRM	CHPF	616	Q8IZ52
PVFPERTQNSMACKR	C12orf42	86	Q96LP6
IAFRCPRSFMDQPLA	SKP2	161	Q13309
FPPLFMEAFSRRRCE	PRAMEF6	36	Q5VXH4
KSFPDDLPRMRFKCP	ZBTB8A	271	Q96BR9
TLPPFMCNKRAEDFQ	SSX2	66	Q16385
FPPLFMEAFSRRRCE	PRAMEF5	36	Q5TYX0
NFRMFSCPKESDPIQ	ZSCAN5A	46	Q9BUG6
CKQPSMDFNRPGTFR	ZCCHC14	921	Q8WYQ9
RRIPAEMALCSPFFS	UHMK1	291	Q8TAS1
NFRMFSCPKESDPIQ	ZSCAN5C	46	A6NGD5
ADPKQRPSFTCLRME	TYRO3	771	Q06418
MLKSRDTRRNFCPPN	UBE3C	611	Q15386