Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctioncalmodulin-dependent protein phosphatase activity

PPP3CA PPP3CB PPP3CC

6.39e-075813GO:0033192
GeneOntologyMolecularFunctioncalcium-dependent protein serine/threonine phosphatase activity

PPP3CA PPP3CB PPP3CC

3.55e-068813GO:0004723
GeneOntologyMolecularFunctionsingle-stranded RNA binding

CIRBP HNRNPCL1 ZFR2 RBMX HNRNPCL2

8.88e-05111815GO:0003727
GeneOntologyMolecularFunctiondeaminase binding

HNRNPCL1 HNRNPCL2

9.70e-054812GO:1990827
GeneOntologyMolecularFunctionpoly(U) RNA binding

CIRBP HNRNPCL1 HNRNPCL2

3.51e-0434813GO:0008266
GeneOntologyMolecularFunctionpoly-pyrimidine tract binding

CIRBP HNRNPCL1 HNRNPCL2

5.29e-0439813GO:0008187
GeneOntologyBiologicalProcessnegative regulation of calcium ion import across plasma membrane

PPP3CA PPP3CB PPP3CC

5.00e-069823GO:1905949
GeneOntologyBiologicalProcesspositive regulation of calcium ion import across plasma membrane

PPP3CA PPP3CB PPP3CC

1.68e-0513823GO:1905665
GeneOntologyBiologicalProcesspositive regulation of mRNA splicing, via spliceosome

CIRBP RBMXL2 RBMXL1 RBMX

2.79e-0544824GO:0048026
GeneOntologyBiologicalProcesspositive regulation of mRNA processing

CIRBP RBMXL2 RBMXL1 RBMX

4.29e-0549824GO:0050685
GeneOntologyBiologicalProcessregulation of calcium ion import across plasma membrane

PPP3CA PPP3CB PPP3CC

5.60e-0519823GO:1905664
GeneOntologyBiologicalProcessregulation of mRNA metabolic process

CIRBP RC3H2 RBMXL2 HNRNPCL1 RBMXL1 RBMX PKP1 ROCK1 HNRNPCL2

6.57e-05443829GO:1903311
GeneOntologyBiologicalProcesspositive regulation of calcineurin-mediated signaling

PPP3CA PPP3CB PPP3CC

7.65e-0521823GO:0106058
GeneOntologyBiologicalProcesspositive regulation of calcineurin-NFAT signaling cascade

PPP3CA PPP3CB PPP3CC

7.65e-0521823GO:0070886
GeneOntologyBiologicalProcessnegative regulation of calcium ion import

PPP3CA PPP3CB PPP3CC

7.65e-0521823GO:0090281
GeneOntologyBiologicalProcessregulation of angiotensin-activated signaling pathway

PPP3CA ROCK1

9.32e-054822GO:0110061
GeneOntologyBiologicalProcessnegative regulation of mRNA metabolic process

CIRBP HNRNPCL1 RBMX PKP1 HNRNPCL2

9.57e-05115825GO:1903312
GeneOntologyBiologicalProcessregulation of calcium ion import

PPP3CA PPP3CB PPP3CC PKD2

1.02e-0461824GO:0090279
GeneOntologyBiologicalProcesspositive regulation of RNA splicing

CIRBP RBMXL2 RBMXL1 RBMX

1.16e-0463824GO:0033120
GeneOntologyBiologicalProcessregulation of telomere maintenance via telomere lengthening

ERCC4 HNRNPCL1 ATR HNRNPCL2

1.65e-0469824GO:1904356
GeneOntologyBiologicalProcessnegative regulation of calcium ion transmembrane transport

PPP3CA PPP3CB PPP3CC PKD2

1.65e-0469824GO:1903170
GeneOntologyBiologicalProcessnegative regulation of mRNA modification

HNRNPCL1 HNRNPCL2

2.32e-046822GO:0090367
GeneOntologyBiologicalProcesspositive regulation of phosphatase activity

MAGI2 PPP1R12A ROCK1

2.51e-0431823GO:0010922
GeneOntologyBiologicalProcessnegative regulation of telomere maintenance via telomere lengthening

ERCC4 HNRNPCL1 HNRNPCL2

3.03e-0433823GO:1904357
GeneOntologyBiologicalProcessregulation of synaptic vesicle endocytosis

PPP3CB PPP3CC ROCK1

3.03e-0433823GO:1900242
GeneOntologyBiologicalProcessregulation of mRNA modification

HNRNPCL1 HNRNPCL2

3.24e-047822GO:0090365
GeneOntologyBiologicalProcesspositive regulation of calcium ion import

PPP3CA PPP3CB PPP3CC

3.32e-0434823GO:0090280
GeneOntologyBiologicalProcessnegative regulation of mRNA catabolic process

CIRBP HNRNPCL1 PKP1 HNRNPCL2

4.02e-0487824GO:1902373
GeneOntologyBiologicalProcessnucleobase-containing compound catabolic process

CIRBP PPARGC1A RC3H2 SETMAR HNRNPCL1 DUT PKP1 ROCK1 ENTPD8 HNRNPCL2

4.29e-046968210GO:0034655
GeneOntologyBiologicalProcesstelomere maintenance via telomere lengthening

ERCC4 HNRNPCL1 ATR HNRNPCL2

4.57e-0490824GO:0010833
GeneOntologyBiologicalProcessdephosphorylation

MAGI2 PPP3CA PPP3CB PPP3CC PPP1R12A THTPA ROCK1

4.63e-04347827GO:0016311
GeneOntologyBiologicalProcessnegative regulation of calcium ion transport

PPP3CA PPP3CB PPP3CC PKD2

4.97e-0492824GO:0051926
GeneOntologyBiologicalProcessprotein dephosphorylation

MAGI2 PPP3CA PPP3CB PPP3CC PPP1R12A ROCK1

5.49e-04256826GO:0006470
GeneOntologyBiologicalProcessmRNA splicing, via spliceosome

CIRBP RBMXL2 HNRNPCL1 RBMXL1 RBMX WBP4 HNRNPCL2

5.57e-04358827GO:0000398
GeneOntologyBiologicalProcessRNA splicing, via transesterification reactions with bulged adenosine as nucleophile

CIRBP RBMXL2 HNRNPCL1 RBMXL1 RBMX WBP4 HNRNPCL2

5.57e-04358827GO:0000377
GeneOntologyBiologicalProcesspositive regulation of mRNA metabolic process

CIRBP RC3H2 RBMXL2 RBMXL1 RBMX ROCK1

5.84e-04259826GO:1903313
GeneOntologyBiologicalProcessRNA splicing, via transesterification reactions

CIRBP RBMXL2 HNRNPCL1 RBMXL1 RBMX WBP4 HNRNPCL2

5.95e-04362827GO:0000375
GeneOntologyBiologicalProcessnegative regulation of telomere maintenance

ERCC4 HNRNPCL1 HNRNPCL2

6.22e-0442823GO:0032205
GeneOntologyBiologicalProcesssynaptic membrane adhesion

MAGI2 TENM4 CDH6

6.22e-0442823GO:0099560
GeneOntologyBiologicalProcesscalcium ion import

PPP3CA PPP3CB PPP3CC PKD2

6.31e-0498824GO:0070509
GeneOntologyBiologicalProcessepithelial cell differentiation

MAGI2 CRYGD PPP3CA PPP1R12A CD109 SAV1 ROCK1 ROS1 IFT80 KEAP1 PRDM1

6.41e-048708211GO:0030855
GeneOntologyBiologicalProcessnegative regulation of DNA biosynthetic process

ERCC4 HNRNPCL1 HNRNPCL2

6.66e-0443823GO:2000279
GeneOntologyBiologicalProcessnegative regulation of RNA catabolic process

CIRBP HNRNPCL1 PKP1 HNRNPCL2

7.07e-04101824GO:1902369
GeneOntologyBiologicalProcessregulation of synaptic vesicle recycling

PPP3CB PPP3CC ROCK1

7.13e-0444823GO:1903421
GeneOntologyBiologicalProcessregulation of calcineurin-NFAT signaling cascade

PPP3CA PPP3CB PPP3CC

7.13e-0444823GO:0070884
GeneOntologyBiologicalProcessregulation of calcineurin-mediated signaling

PPP3CA PPP3CB PPP3CC

7.62e-0445823GO:0106056
GeneOntologyBiologicalProcessRNA splicing

CIRBP PPARGC1A RBMXL2 HNRNPCL1 RBMXL1 RBMX WBP4 HNRNPCL2

8.57e-04502828GO:0008380
GeneOntologyBiologicalProcessnegative regulation of chromosome organization

SETMAR ERCC4 HNRNPCL1 HNRNPCL2

8.77e-04107824GO:2001251
GeneOntologyBiologicalProcesscalcium ion import across plasma membrane

PPP3CA PPP3CB PPP3CC

9.21e-0448823GO:0098703
GeneOntologyBiologicalProcesscalcium ion import into cytosol

PPP3CA PPP3CB PPP3CC

9.21e-0448823GO:1902656
GeneOntologyBiologicalProcesspositive regulation of calcium ion transmembrane transport

PPP3CA PPP3CB PPP3CC PKD2

9.40e-04109824GO:1904427
GeneOntologyBiologicalProcessmRNA metabolic process

CIRBP PPARGC1A RC3H2 RBMXL2 HNRNPCL1 RBMXL1 RBMX WBP4 PKP1 ROCK1 HNRNPCL2

9.86e-049178211GO:0016071
GeneOntologyBiologicalProcessresponse to glycoprotein

SLC5A5 MAN1B1

1.00e-0312822GO:1904587
GeneOntologyBiologicalProcessregulation of telomere maintenance

ERCC4 HNRNPCL1 ATR HNRNPCL2

1.04e-03112824GO:0032204
GeneOntologyBiologicalProcesscell-cell adhesion

MAGI2 DCHS2 RC3H2 PPP3CA TENM4 TLN1 ETS1 PKP1 ROCK1 DCC CDH6 CDON

1.09e-0310778212GO:0098609
GeneOntologyCellularComponentcalcineurin complex

PPP3CA PPP3CB PPP3CC

1.11e-066813GO:0005955
GeneOntologyCellularComponentspliceosomal complex

CIRBP RBMXL2 HNRNPCL1 RBMXL1 RBMX WBP4 HNRNPCL2

2.01e-05215817GO:0005681
GeneOntologyCellularComponentphosphatase complex

PPP3CA PPP3CB PPP3CC PPP1R12A

6.14e-0555814GO:1903293
GeneOntologyCellularComponentprotein serine/threonine phosphatase complex

PPP3CA PPP3CB PPP3CC PPP1R12A

6.14e-0555814GO:0008287
GeneOntologyCellularComponentsupraspliceosomal complex

RBMXL1 RBMX

8.85e-054812GO:0044530
GeneOntologyCellularComponentnucleoplasmic periphery of the nuclear pore complex

HNRNPCL1 HNRNPCL2

2.20e-046812GO:1990826
GeneOntologyCellularComponentactin cytoskeleton

MYH11 HNRNPCL1 ACACA MYH14 PPP1R12A CAPZB TTC17 KEAP1 HNRNPCL2

3.85e-04576819GO:0015629
GeneOntologyCellularComponentcell-cell junction

MAGI2 DCHS2 PPP3CA TLN1 PKD2 PKP1 ABCB11 KEAP1 CDH6

4.63e-04591819GO:0005911
GeneOntologyCellularComponentfiltration diaphragm

MAGI2 PPP3CA

7.97e-0411812GO:0036056
GeneOntologyCellularComponentslit diaphragm

MAGI2 PPP3CA

7.97e-0411812GO:0036057
GeneOntologyCellularComponentendoplasmic reticulum quality control compartment

DERL1 MAN1B1

1.94e-0317812GO:0044322
GeneOntologyCellularComponentextrinsic component of plasma membrane

MAGI2 PPP3CA CUBN CDH6

1.99e-03137814GO:0019897
GeneOntologyCellularComponentextrinsic component of membrane

MAGI2 PPP3CA ATR CUBN CDH6

2.01e-03230815GO:0019898
DomainRRM_dom_euk

CIRBP RBMXL2 RBMXL1 RBMX

2.73e-0623814IPR003954
DomainRRM_1

CIRBP RBMXL2 RBMXL1 RBMX

2.73e-0623814SM00361
DomainRBM1CTR

RBMXL2 RBMXL1 RBMX

4.33e-068813PF08081
DomainRBM1CTR

RBMXL2 RBMXL1 RBMX

4.33e-068813IPR012604
DomainSer/Thr-sp_prot-phosphatase

PPP3CA PPP3CB PPP3CC

2.18e-0513813IPR006186
DomainSER_THR_PHOSPHATASE

PPP3CA PPP3CB PPP3CC

2.18e-0513813PS00125
DomainPP2Ac

PPP3CA PPP3CB PPP3CC

2.18e-0513813SM00156
DomainRRM_1

CIRBP PPARGC1A RBMXL2 HNRNPCL1 RBMXL1 RBMX HNRNPCL2

3.32e-05208817PF00076
DomainRRM

CIRBP PPARGC1A RBMXL2 HNRNPCL1 RBMXL1 RBMX HNRNPCL2

4.35e-05217817SM00360
DomainWW

MAGI2 ARHGAP12 WBP4 SAV1

5.08e-0547814PF00397
DomainWW

MAGI2 ARHGAP12 WBP4 SAV1

5.52e-0548814SM00456
DomainRRM_dom

CIRBP PPARGC1A RBMXL2 HNRNPCL1 RBMXL1 RBMX HNRNPCL2

5.79e-05227817IPR000504
DomainRRM

CIRBP PPARGC1A RBMXL2 HNRNPCL1 RBMXL1 RBMX HNRNPCL2

6.29e-05230817PS50102
DomainWW_DOMAIN_2

MAGI2 ARHGAP12 WBP4 SAV1

7.03e-0551814PS50020
DomainWW_DOMAIN_1

MAGI2 ARHGAP12 WBP4 SAV1

7.03e-0551814PS01159
DomainWW_dom

MAGI2 ARHGAP12 WBP4 SAV1

7.59e-0552814IPR001202
Domain-

CIRBP PPARGC1A RBMXL2 HNRNPCL1 RBMXL1 RBMX HNRNPCL2

9.11e-052448173.30.70.330
DomainNucleotide-bd_a/b_plait

CIRBP PPARGC1A RBMXL2 HNRNPCL1 RBMXL1 RBMX HNRNPCL2

1.29e-04258817IPR012677
DomainCalcineurin-like_PHP_ApaH

PPP3CA PPP3CB PPP3CC

2.38e-0428813IPR004843
DomainMetallophos

PPP3CA PPP3CB PPP3CC

2.38e-0428813PF00149
DomainhnRNP_C

HNRNPCL1 HNRNPCL2

2.76e-046812IPR017347
DomainMetallo-depent_PP-like

PPP3CA PPP3CB PPP3CC

2.93e-0430813IPR029052
Domain-

PPP3CA PPP3CB PPP3CC

2.93e-04308133.60.21.10
DomainMyosin_N

MYH11 MYH14

1.88e-0315812PF02736
DomainMyosin_N

MYH11 MYH14

1.88e-0315812IPR004009
DomainHEAT_type_2

MROH1 ATR

2.42e-0317812IPR021133
DomainMyosin_tail_1

MYH11 MYH14

2.72e-0318812PF01576
DomainMyosin_tail

MYH11 MYH14

2.72e-0318812IPR002928
DomainMyosin-like_IQ_dom

MYH11 MYH14

3.03e-0319812IPR027401
Domain-

MYH11 MYH14

3.03e-03198124.10.270.10
Domainfn3

TRIM67 ROS1 DCC CDON

5.41e-03162814PF00041
PathwayBIOCARTA_PGC1A_PATHWAY

PPARGC1A PPP3CA PPP3CB PPP3CC

3.28e-0714624MM1473
PathwayBIOCARTA_PGC1A_PATHWAY

PPARGC1A PPP3CA PPP3CB PPP3CC

4.46e-0715624M15181
PathwayREACTOME_RHO_GTPASES_ACTIVATE_ROCKS

MYH11 MYH14 PPP1R12A ROCK1

1.25e-0619624M27493
PathwayREACTOME_RHOBTB1_GTPASE_CYCLE

HNRNPCL1 RBMX ROCK1 HNRNPCL2

4.00e-0625624MM15608
PathwayKEGG_MEDICUS_REFERENCE_LYSOSOMAL_CA2_RELEASE

PPP3CA PPP3CB PPP3CC

9.51e-0610623M47954
PathwayKEGG_MEDICUS_REFERENCE_CA2_CAM_CN_SIGNALING_PATHWAY

PPP3CA PPP3CB PPP3CC

1.73e-0512623M47956
PathwayREACTOME_RHOBTB_GTPASE_CYCLE

HNRNPCL1 RBMX ROCK1 HNRNPCL2

2.01e-0537624MM15683
PathwayWP_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS

PPP3CA PPP3CB PPP3CC DERL1

2.24e-0538624M39357
PathwayBIOCARTA_NDKDYNAMIN_PATHWAY

PPP3CA PPP3CB PPP3CC

3.55e-0515623MM1387
PathwayBIOCARTA_MEF2D_PATHWAY

PPP3CA PPP3CB PPP3CC

4.36e-0516623MM1483
PathwayKEGG_MEDICUS_REFERENCE_EGF_EGFR_PLCG_CALCINEURIN_SIGNALING_PATHWAY

PPP3CA PPP3CB PPP3CC

4.36e-0516623M47449
PathwayKEGG_MEDICUS_PATHOGEN_HIV_GP120_TO_CXCR4_GNAQ_PLCB_G_CALCINEURIN

PPP3CA PPP3CB PPP3CC

5.27e-0517623M47560
PathwayBIOCARTA_NDKDYNAMIN_PATHWAY

PPP3CA PPP3CB PPP3CC

5.27e-0517623M5940
PathwayWP_ENERGY_METABOLISM

PPARGC1A PPP3CA PPP3CB PPP3CC

5.71e-0548624M39590
PathwayKEGG_MEDICUS_REFERENCE_BCR_PLCG_CALCINEURIN_SIGNALING_PATHWAY

PPP3CA PPP3CB PPP3CC

6.31e-0518623M47580
PathwayBIOCARTA_MEF2D_PATHWAY

PPP3CA PPP3CB PPP3CC

6.31e-0518623M5290
PathwayBIOCARTA_CALCINEURIN_PATHWAY

PPP3CA PPP3CB PPP3CC

6.31e-0518623MM1385
PathwayBIOCARTA_CALCINEURIN_PATHWAY

PPP3CA PPP3CB PPP3CC

6.31e-0518623M3430
PathwayREACTOME_RHO_GTPASES_ACTIVATE_CIT

MYH11 MYH14 PPP1R12A

7.47e-0519623M27489
PathwayKEGG_MEDICUS_PATHOGEN_HCMV_US28_TO_GNAQ_PLCB_G_CALCINEURIN_SIGNALING_PATHWAY

PPP3CA PPP3CB PPP3CC

7.47e-0519623M47543
PathwayKEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS

PPP3CA PPP3CB PPP3CC DERL1

8.45e-0553624M3812
PathwayREACTOME_SEMA4D_INDUCED_CELL_MIGRATION_AND_GROWTH_CONE_COLLAPSE

MYH11 MYH14 ROCK1

8.76e-0520623M18415
PathwayBIOCARTA_NOS1_PATHWAY

PPP3CA PPP3CB PPP3CC

8.76e-0520623MM1445
PathwayWP_CALCIUM_MEDIATED_TCELL_APOPTOSIS_INVOLVED_IN_INCLUSION_BODY_MYOSITIS

PPP3CA PPP3CB PPP3CC

8.76e-0520623M48330
PathwayBIOCARTA_NOS1_PATHWAY

PPP3CA PPP3CB PPP3CC

1.02e-0421623M11650
PathwayREACTOME_RHO_GTPASES_ACTIVATE_PAKS

MYH11 MYH14 PPP1R12A

1.02e-0421623M27494
PathwayKEGG_MEDICUS_REFERENCE_CXCR4_GNAQ_PLCB_G_CALCINEURIN_SIGNALING_PATHWAY

PPP3CA PPP3CB PPP3CC

1.02e-0421623M47542
PathwayREACTOME_RHO_GTPASES_ACTIVATE_PAKS

MYH11 MYH14 PPP1R12A

1.35e-0423623MM15222
PathwayREACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING

MYH11 MYH14 ROCK1

1.54e-0424623M2243
PathwayREACTOME_DARPP_32_EVENTS

PPP3CA PPP3CB PPP3CC

1.54e-0424623M751
PathwayPID_BCR_5PATHWAY

PPP3CA PPP3CB PPP3CC ETS1

1.66e-0463624M10
PathwayBIOCARTA_HDAC_PATHWAY

PPP3CA PPP3CB PPP3CC

1.74e-0425623M1547
PathwayBIOCARTA_VIP_PATHWAY

PPP3CA PPP3CB PPP3CC

1.74e-0425623MM1441
PathwayREACTOME_RHOBTB2_GTPASE_CYCLE

HNRNPCL1 RBMX HNRNPCL2

1.74e-0425623MM15606
PathwayREACTOME_SEMAPHORIN_INTERACTIONS

MYH11 MYH14 TLN1 ROCK1

1.77e-0464624M7923
PathwayBIOCARTA_VIP_PATHWAY

PPP3CA PPP3CB PPP3CC

1.96e-0426623M17941
PathwayBIOCARTA_HDAC_PATHWAY

PPP3CA PPP3CB PPP3CC

1.96e-0426623MM1371
PathwayKEGG_LONG_TERM_POTENTIATION

PPP3CA PPP3CB PPP3CC PPP1R12A

2.50e-0470624M3115
PathwayKEGG_AXON_GUIDANCE

PPP3CA PPP3CB PPP3CC ROCK1 DCC

2.53e-04129625M5539
PathwayREACTOME_EPHA_MEDIATED_GROWTH_CONE_COLLAPSE

MYH11 MYH14 ROCK1

2.73e-0429623M27309
PathwayBIOCARTA_GPCR_PATHWAY

PPP3CA PPP3CB PPP3CC

2.73e-0429623MM1495
PathwayBIOCARTA_GPCR_PATHWAY

PPP3CA PPP3CB PPP3CC

3.02e-0430623M9664
PathwayBIOCARTA_BCR_PATHWAY

PPP3CA PPP3CB PPP3CC

3.67e-0432623MM1355
PathwayWP_INITIATION_OF_TRANSCRIPTION_AND_TRANSLATION_ELONGATION_AT_THE_HIV1_LTR

PPP3CA PPP3CB PPP3CC

3.67e-0432623M39521
PathwayBIOCARTA_BCR_PATHWAY

PPP3CA PPP3CB PPP3CC

4.02e-0433623M9494
PathwayBIOCARTA_FMLP_PATHWAY

PPP3CA PPP3CB PPP3CC

4.40e-0434623M10287
PathwayBIOCARTA_FMLP_PATHWAY

PPP3CA PPP3CB PPP3CC

4.40e-0434623MM1399
PathwayBIOCARTA_FCER1_PATHWAY

PPP3CA PPP3CB PPP3CC

6.61e-0439623MM1397
PathwayBIOCARTA_FCER1_PATHWAY

PPP3CA PPP3CB PPP3CC

6.61e-0439623M1908
PathwayREACTOME_CALCINEURIN_ACTIVATES_NFAT

PPP3CA PPP3CB

6.72e-049622M27106
PathwayWP_MRNA_PROCESSING

CIRBP PPARGC1A RBMXL2 HNRNPCL1 RBMXL1 RBMX WBP4 HNRNPCL2

7.66e-04451628MM15946
PathwayBIOCARTA_TCR_PATHWAY

PPP3CA PPP3CB PPP3CC

8.23e-0442623MM1504
PathwayBIOCARTA_TCR_PATHWAY

PPP3CA PPP3CB PPP3CC

9.44e-0444623M19784
PathwayWP_NEURODEGENERATION_WITH_BRAIN_IRON_ACCUMULATION_NBIA_SUBTYPES_PATHWAY

ACACA CP FTL

9.44e-0444623M39602
PathwayPID_RHOA_PATHWAY

PPP1R12A TLN1 ROCK1

1.01e-0345623M12
PathwayREACTOME_CALCINEURIN_ACTIVATES_NFAT

PPP3CA PPP3CB

1.02e-0311622MM14810
PathwayREACTOME_CLEC7A_DECTIN_1_INDUCES_NFAT_ACTIVATION

PPP3CA PPP3CB

1.02e-0311622M27466
PathwayREACTOME_DISORDERS_OF_TRANSMEMBRANE_TRANSPORTERS

SLC5A5 DERL1 PSMB6 ABCB11 CP

1.07e-03177625M27476
PathwaySIG_BCR_SIGNALING_PATHWAY

PPP3CA PPP3CB PPP3CC

1.07e-0346623M8626
PathwayREACTOME_APOPTOSIS

PPP3CC PSMB6 PKP1 ROCK1 DCC

1.13e-03179625M15303
PathwayREACTOME_APOPTOSIS

PPP3CC PKP1 ROCK1 DCC

1.29e-03108624MM14471
PathwayBIOCARTA_NFAT_PATHWAY

PPP3CA PPP3CB PPP3CC

1.29e-0349623MM1442
PathwayBIOCARTA_NFAT_PATHWAY

PPP3CA PPP3CB PPP3CC

1.45e-0351623M2288
PathwayREACTOME_SIGNALING_BY_RHO_GTPASES_MIRO_GTPASES_AND_RHOBTB3

MYH11 HNRNPCL1 MYH14 PPP1R12A RBMX ARHGAP12 CAPZB ROCK1 HNRNPCL2

2.00e-03649629MM15690
PathwayREACTOME_PROGRAMMED_CELL_DEATH

PPP3CC PSMB6 PKP1 ROCK1 DCC

2.32e-03211625M27436
PathwayREACTOME_METABOLISM_OF_WATER_SOLUBLE_VITAMINS_AND_COFACTORS

ACACA RNLS THTPA CUBN

2.34e-03127624M27093
PathwayWP_IRON_METABOLISM_DISORDERS

CP FTL

2.48e-0317622M48053
PathwayKEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY

PPP3CA PPP3CB PPP3CC MICB

3.08e-03137624M5669
PathwayWP_MITOCHONDRIAL_GENE_EXPRESSION

PPARGC1A PPP3CA

3.10e-0319622M39544
PathwayWP_MITOCHONDRIAL_GENE_EXPRESSION

PPARGC1A PPP3CA

3.10e-0319622MM15973
PathwayWP_FARNESOID_X_RECEPTOR_PATHWAY

PPARGC1A ABCB11

3.10e-0319622M39411
PathwayBIOCARTA_ECM_PATHWAY

TLN1 ROCK1

3.10e-0319622M6355
PathwayWP_HEREDITARY_LEIOMYOMATOSIS_AND_RENAL_CELL_CARCINOMA_PATHWAY

ACACA KEAP1

3.44e-0320622M39751
PathwayBIOCARTA_RHO_PATHWAY

TLN1 ROCK1

3.44e-0320622MM1476
PathwayREACTOME_PROGRAMMED_CELL_DEATH

PPP3CC PKP1 ROCK1 DCC

3.50e-03142624MM15178
Pubmed

Cloning and characterization of molecular isoforms of the catalytic subunit of calcineurin using nonisotopic methods.

PPP3CA PPP3CB PPP3CC

1.26e-0838232162844
Pubmed

The proline-rich N-terminal sequence of calcineurin Abeta determines substrate binding.

PPP3CA PPP3CB PPP3CC

1.26e-08382319154138
Pubmed

Chromosomal mapping of the human genes for the calmodulin-dependent protein phosphatase (calcineurin) catalytic subunit.

PPP3CA PPP3CB PPP3CC

1.26e-0838231659808
Pubmed

Calcineurin signaling and PGC-1alpha expression are suppressed during muscle atrophy due to diabetes.

PPARGC1A PPP3CA PPP3CB

1.26e-08382320359506
Pubmed

Molecular and phylogenetic analysis of calmodulin-dependent protein phosphatase (calcineurin) catalytic subunit genes.

PPP3CA PPP3CB PPP3CC

5.04e-0848231318721
Pubmed

Deletion of calcineurin and myocyte enhancer factor 2 (MEF2) binding domain of Cabin1 results in enhanced cytokine gene expression in T cells.

PPP3CA PPP3CB PPP3CC

5.04e-08482311714752
Pubmed

Calcineurin: form and function.

PPP3CA PPP3CB PPP3CC

1.26e-07582311015619
Pubmed

Polymorphisms in the calcineurin genes are associated with the training responsiveness of cardiac phenotypes in Chinese young adults.

PPP3CA PPP3CB PPP3CC

1.26e-07582320593291
Pubmed

Elevated expression of calcineurin subunits during active mineralization of developing mouse molar teeth.

PPP3CA PPP3CB PPP3CC

1.26e-07582322984995
Pubmed

Are calcineurin genes associated with endurance phenotype traits?

PPP3CA PPP3CB PPP3CC

1.26e-07582320107831
Pubmed

Tbx15 controls skeletal muscle fibre-type determination and muscle metabolism.

PPARGC1A PPP3CA ACACA SDHA

1.35e-072082426299309
Pubmed

Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.

PPARGC1A NOL4L ERCC4 PPP3CB PPP1R12A RBMX PSMB6 ETS1 PEX1 DIDO1 ROCK1 CUBN DSE MAN1B1

2.30e-071084821411544199
Pubmed

Mammalian brain phosphoproteins as substrates for calcineurin.

PPP3CA PPP3CB PPP3CC

2.51e-0768236330098
Pubmed

The protein serine/threonine phosphatases PP2A, PP1 and calcineurin: A triple threat in the regulation of the neuronal cytoskeleton.

PPP3CA PPP3CB PPP3CC

4.39e-07782328126489
Pubmed

Calcineurin binds the transcription factor NFAT1 and reversibly regulates its activity.

PPP3CA PPP3CB PPP3CC

4.39e-0778238631904
Pubmed

Low affinity Ca2+-binding sites of calcineurin B mediate conformational changes in calcineurin A.

PPP3CA PPP3CB PPP3CC

4.39e-07782311123943
Pubmed

AKAP79/150 anchoring of calcineurin controls neuronal L-type Ca2+ channel activity and nuclear signaling.

PPP3CA PPP3CB PPP3CC

7.01e-07882317640527
Pubmed

Balanced interactions of calcineurin with AKAP79 regulate Ca2+-calcineurin-NFAT signaling.

PPP3CA PPP3CB PPP3CC

1.05e-06982322343722
Pubmed

SPATA33 localizes calcineurin to the mitochondria and regulates sperm motility in mice.

PPP3CA PPP3CB PPP3CC

1.05e-06982334446558
Pubmed

A reassessment of the inhibitory capacity of human FKBP38 on calcineurin.

PPP3CA PPP3CB PPP3CC

2.74e-061282315757646
Pubmed

NRIP is newly identified as a Z-disc protein, activating calmodulin signaling for skeletal muscle contraction and regeneration.

PPARGC1A PPP3CA SDHA

3.55e-061382326430214
Pubmed

Extensive alternative splicing transitions during postnatal skeletal muscle development are required for calcium handling functions.

PPP3CA PPP3CB PPP3CC

4.51e-061482328826478
Pubmed

Large-scale proteomics and phosphoproteomics of urinary exosomes.

DNHD1 MYH14 P3H1 TLN1 VPS50 PSMB6 PKD2 CAPZB ABCB11 CP FTL CUBN

4.58e-061016821219056867
Pubmed

Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage.

RBMXL2 HNRNPCL1 DERL1 RBMXL1 MYH14 RBMX TLN1 DUT PSMB6 CAPZB PKP1

4.70e-06844821125963833
Pubmed

Coexpression of calcineurin A and B subunits in various subcellular and synaptic compartments of cerebellar neurons and glia with particular abundance at parallel fiber-Purkinje cell synapses.

PPP3CA PPP3CB

5.49e-06282235247520
Pubmed

A novel gravity-induced blood flow restriction model augments ACC phosphorylation and PGC-1α mRNA in human skeletal muscle following aerobic exercise: a randomized crossover study.

PPARGC1A ACACA

5.49e-06282231778310
Pubmed

The role of calcium/calmodulin-activated calcineurin in rapid and slow endocytosis at central synapses.

PPP3CA PPP3CB

5.49e-06282220810903
Pubmed

Genome-Wide Identification of Target Genes for the Key B Cell Transcription Factor Ets1.

ETS1 PRDM1

5.49e-06282228439269
Pubmed

Calcineurin A-alpha but not A-beta is required for normal kidney development and function.

PPP3CA PPP3CB

5.49e-06282215509543
Pubmed

Constitutively active calcineurin in skeletal muscle increases endurance performance and mitochondrial respiratory capacity.

PPP3CA PPP3CB

5.49e-06282219861587
Pubmed

Inhibition of calcineurin phosphatase promotes exocytosis of renin from juxtaglomerular cells.

PPP3CA PPP3CB

5.49e-06282219907416
Pubmed

Chromosomal assignments of the genes for the calcineurin A alpha (Calna1) and A beta subunits (Calna2) in the rat.

PPP3CA PPP3CB

5.49e-0628228187553
Pubmed

Dephosphorylation of the small heat shock protein hsp25 by calcium/calmodulin-dependent (type 2B) protein phosphatase.

PPP3CA PPP3CB

5.49e-0628221328240
Pubmed

Genetic Variability in the Iron Homeostasis Pathway and Patient Outcomes After Aneurysmal Subarachnoid Hemorrhage.

CP CUBN

5.49e-06282232246437
Pubmed

Genetic conservation of the immunophilin-binding domains of human calcineurin A1 and A2.

PPP3CA PPP3CB

5.49e-06282211005320
Pubmed

Calcineurin expression and activity is regulated by the intracellular redox status and under hypertension in human neutrophils.

PPP3CA PPP3CB

5.49e-06282222739212
Pubmed

Are calcineurin genes associated with athletic status? A function, replication study.

PPP3CA PPP3CB

5.49e-06282221233773
Pubmed

Novel domains in the hnRNP G/RBMX protein with distinct roles in RNA binding and targeting nascent transcripts.

RBMXL2 RBMX

5.49e-06282221327109
Pubmed

Cloning of human calcineurin A: evidence for two isozymes and identification of a polyproline structural domain.

PPP3CA PPP3CB

5.49e-0628222556704
Pubmed

Oxidation-induced conformational changes in calcineurin determined by covalent labeling and tandem mass spectrometry.

PPP3CA PPP3CB

5.49e-06282225286016
Pubmed

Compensatory renal hypertrophy following uninephrectomy is calcineurin-independent.

PPP3CA PPP3CB

5.49e-06282225287476
Pubmed

ETS-1 facilitates Th1 cell-mediated mucosal inflammation in inflammatory bowel diseases through upregulating CIRBP.

CIRBP ETS1

5.49e-06282235926374
Pubmed

Using genetic and clinical factors to predict tacrolimus dose in renal transplant recipients.

PPP3CA PPP3CB PPP3CC

5.63e-061582321047202
Pubmed

Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors.

MAGI2 ACACA DERL1 P3H1 TLN1 DUT CD109 PKD2 PKP1 CP MMP11 GFM2 SDHA MAN1B1

7.01e-061451821430550785
Pubmed

A high-throughput approach for measuring temporal changes in the interactome.

PPP3CA PPP3CB ACACA MYH14 P3H1 PPP1R12A TLN1 DUT PSMB6 CAPZB ROCK1 WDR12 FTL NEK9

7.23e-061455821422863883
Pubmed

Chemokine co-receptor CCR5/CXCR4-dependent modulation of Kv2.1 channel confers acute neuroprotection to HIV-1 glycoprotein gp120 exposure.

PPP3CA PPP3CB PPP3CC

8.39e-061782324086760
Pubmed

A method to identify cDNAs based on localization of green fluorescent protein fusion products.

HNRNPCL1 RBMXL1 HNRNPCL2

8.39e-061782310716735
Pubmed

New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules.

HNRNPCL1 PPP3CB ATR RBMXL1 RBMX SAV1 KEAP1 HNRNPCL2

1.38e-0546282831138677
Pubmed

Cul3-Klhl18 ubiquitin ligase modulates rod transducin translocation during light-dark adaptation.

PPP3CA PPP3CB PPP3CC

1.63e-052182331696965
Pubmed

Upregulation of sphingosine kinase 1 contributes to ventilator-associated lung injury in a two-hit model.

PPP1R12A ROCK1

1.64e-05382231638192
Pubmed

Transcriptional control of CBX5 by the RNA binding proteins RBMX and RBMXL1 maintains chromatin state in myeloid leukemia.

RBMXL1 RBMX

1.64e-05382234458856
Pubmed

RBMX is a novel hepatic transcriptional regulator of SREBP-1c gene response to high-fructose diet.

RBMXL1 RBMX

1.64e-05382217188681
Pubmed

Calcineurin interacts with PERK and dephosphorylates calnexin to relieve ER stress in mammals and frogs.

PPP3CA PPP3CB

1.64e-05382220700529
Pubmed

Altered skeletal muscle phenotypes in calcineurin Aalpha and Abeta gene-targeted mice.

PPP3CA PPP3CB

1.64e-05382212773574
Pubmed

Phasic contractions of isolated human myometrium are associated with Rho-kinase (ROCK)-dependent phosphorylation of myosin phosphatase-targeting subunit (MYPT1).

PPP1R12A ROCK1

1.64e-05382222155728
Pubmed

Calcineurin protects the heart in a murine model of dilated cardiomyopathy.

PPP3CA PPP3CB

1.64e-05382219854199
Pubmed

Calcineurin A alpha (PPP3CA), calcineurin A beta (PPP3CB) and calcineurin B (PPP3R1) are located on human chromosomes 4, 10q21-->q22 and 2p16-->p15 respectively.

PPP3CA PPP3CB

1.64e-0538228978785
Pubmed

RBMX is required for activation of ATR on repetitive DNAs to maintain genome stability.

ATR RBMX

1.64e-05382232494026
Pubmed

Caspase-3-mediated cleavage of ROCK I induces MLC phosphorylation and apoptotic membrane blebbing.

PPP1R12A ROCK1

1.64e-05382211283607
Pubmed

RBMY evolved on the Y chromosome from a ubiquitously transcribed X-Y identical gene.

RBMXL1 RBMX

1.64e-05382210391207
Pubmed

Vascular smooth muscle cell glycocalyx mediates shear stress-induced contractile responses via a Rho kinase (ROCK)-myosin light chain phosphatase (MLCP) pathway.

PPP1R12A ROCK1

1.64e-05382228191820
Pubmed

Molecular cloning of a full-length cDNA encoding the catalytic subunit of human calmodulin-dependent protein phosphatase (calcineurin A alpha).

PPP3CA PPP3CB

1.64e-0538228392375
Pubmed

Tau binds both subunits of calcineurin, and binding is impaired by calmodulin.

PPP3CA PPP3CB

1.64e-05382218639592
Pubmed

Phosphorylation of the myosin phosphatase targeting subunit and CPI-17 during Ca2+ sensitization in rabbit smooth muscle.

PPP1R12A ROCK1

1.64e-05382212563012
Pubmed

Myospryn is a calcineurin-interacting protein that negatively modulates slow-fiber-type transformation and skeletal muscle regeneration.

PPP3CA PPP3CB

1.64e-05382221427212
Pubmed

Regulation of myosin phosphatase through phosphorylation of the myosin-binding subunit in platelet activation.

PPP1R12A ROCK1

1.64e-0538229354661
Pubmed

Calcineurin functions in Ca(2+)-activated cell death in mammalian cells.

PPP3CA PPP3CB

1.64e-0538227593193
Pubmed

Cabin 1, a negative regulator for calcineurin signaling in T lymphocytes.

PPP3CA PPP3CB

1.64e-0538229655484
Pubmed

Ets-1 facilitates nuclear entry of NFAT proteins and their recruitment to the IL-2 promoter.

ETS1 PRDM1

1.64e-05382224019486
Pubmed

Heart-specific small subunit of myosin light chain phosphatase activates rho-associated kinase and regulates phosphorylation of myosin phosphatase target subunit 1.

PPP1R12A ROCK1

1.64e-05382220801872
Pubmed

Cooperative autoinhibition and multi-level activation mechanisms of calcineurin.

PPP3CA PPP3CB

1.64e-05382226794871
Pubmed

Myosin phosphatase and RhoA-activated kinase modulate arginine methylation by the regulation of protein arginine methyltransferase 5 in hepatocellular carcinoma cells.

PPP1R12A ROCK1

1.64e-05382228074910
Pubmed

Alterations in the brain interactome of the intrinsically disordered N-terminal domain of the cellular prion protein (PrPC) in Alzheimer's disease.

MAGI2 PPP3CA PPP3CB TLN1 DUT CAPZB THTPA

1.66e-0534182729791485
Pubmed

A genome-wide in situ hybridization map of RNA-binding proteins reveals anatomically restricted expression in the developing mouse brain.

CIRBP PPARGC1A RBMXL2 HNRNPCL1 RBMXL1 RBMX HNRNPCL2

1.85e-0534782716033648
Pubmed

Biological pathway-based genome-wide association analysis identified the vasoactive intestinal peptide (VIP) pathway important for obesity.

PPP3CA PPP3CB PPP3CC

2.16e-052382320379146
Pubmed

Proteomic characterization of chromosomal common fragile site (CFS)-associated proteins uncovers ATRX as a regulator of CFS stability.

ERCC4 HNRNPCL1 RBMXL1 MYH14 RBMX TLN1 CAPZB PKP1 DIDO1

2.35e-0565282931180492
Pubmed

Transcriptome analysis of mouse stem cells and early embryos.

MAGI2 HNRNPCL1 ACACA ETS1 DCC CDH6 HNRNPCL2

2.47e-0536382714691545
Pubmed

Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.

DNHD1 ACACA ATR MYH14 RBMX TLN1 DUT CAPZB PKP1 WDR12 UTP3 NEK9 SDHA

2.79e-051425821330948266
Pubmed

N6-methylation of RNA-bound adenosine regulator HNRNPC promotes vascular endothelial dysfunction in type 2 diabetes mellitus by activating the PSEN1-mediated Notch pathway.

HNRNPCL1 HNRNPCL2

3.28e-05482236681355
Pubmed

Impaired vascular remodeling in the yolk sac of embryos deficient in ROCK-I and ROCK-II.

PPP1R12A ROCK1

3.28e-05482221895889
Pubmed

miR-23a is decreased during muscle atrophy by a mechanism that includes calcineurin signaling and exosome-mediated export.

PPP3CA PPP3CB

3.28e-05482224336651
Pubmed

Catalytic subunits of the phosphatase calcineurin interact with NF-κB-inducing kinase (NIK) and attenuate NIK-dependent gene expression.

PPP3CA PPP3CB

3.28e-05482226029823
Pubmed

Phosphorylation of the regulatory subunit of smooth muscle protein phosphatase 1M at Thr850 induces its dissociation from myosin.

PPP1R12A ROCK1

3.28e-05482212220642
Pubmed

Structure and expression of two isoforms of the murine calmodulin-dependent protein phosphatase regulatory subunit (calcineurin B).

PPP3CB PPP3CC

3.28e-0548221325794
Pubmed

Activation of RhoA and inhibition of myosin phosphatase as important components in hypertension in vascular smooth muscle.

PPP1R12A ROCK1

3.28e-05482212600888
Pubmed

Plasma membrane Ca2+-ATPase isoform 4 antagonizes cardiac hypertrophy in association with calcineurin inhibition in rodents.

PPP3CA PPP3CB

3.28e-05482219287093
Pubmed

Inhibitory phosphorylation site for Rho-associated kinase on smooth muscle myosin phosphatase.

PPP1R12A ROCK1

3.28e-05482210601309
Pubmed

Phosphorylation of calcipressin 1 increases its ability to inhibit calcineurin and decreases calcipressin half-life.

PPP3CA PPP3CB

3.28e-05482212809556
Pubmed

Lysosomal calcium signalling regulates autophagy through calcineurin and ​TFEB.

PPP3CA PPP3CB

3.28e-05482225720963
Pubmed

Genetic loss of calcineurin blocks mechanical overload-induced skeletal muscle fiber type switching but not hypertrophy.

PPP3CA PPP3CB

3.28e-05482215082723
Pubmed

The splicing factor hnRNP C regulates expression of co-stimulatory molecules CD80 and CD40 in dendritic cells.

HNRNPCL1 HNRNPCL2

3.28e-05482223831410
Pubmed

hnRNP C is required for postimplantation mouse development but Is dispensable for cell viability.

HNRNPCL1 HNRNPCL2

3.28e-05482210805751
Pubmed

hnRNPC induces isoform shifts in miR-21-5p leading to cancer development.

HNRNPCL1 HNRNPCL2

3.28e-05482235729324
Pubmed

SAFB1, an RBMX-binding protein, is a newly identified regulator of hepatic SREBP-1c gene.

RBMXL1 RBMX

3.28e-05482219403048
Pubmed

Cdc42-MRCK and Rho-ROCK signalling cooperate in myosin phosphorylation and cell invasion.

PPP1R12A ROCK1

3.28e-05482215723050
Pubmed

Ets-1 regulates plasma cell differentiation by interfering with the activity of the transcription factor Blimp-1.

ETS1 PRDM1

3.28e-05482217977828
Pubmed

Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.

PPP3CB RBMXL1 PPP1R12A RBMX CD109 CAPZB PKP1 DIDO1 WDR12 KEAP1 UTP3 SDHA

3.78e-051257821236526897
Pubmed

ATR checkpoint kinase and CRL1βTRCP collaborate to degrade ASF1a and thus repress genes overlapping with clusters of stalled replication forks.

ATR UTP3

5.47e-05582224700029
Pubmed

Chk1 modulates the interaction between myosin phosphatase targeting protein 1 (MYPT1) and protein phosphatase 1cβ (PP1cβ).

PPP1R12A NEK9

5.47e-05582229262732
Pubmed

Crystal structures of human calcineurin and the human FKBP12-FK506-calcineurin complex.

PPP3CA PPP3CB

5.47e-0558228524402
InteractionOGA interactions

PPARGC1A PPP3CA TRIM67 ACACA RBMX CAPZB DIDO1

8.06e-07129807int:OGA
InteractionCABIN1 interactions

ERCC4 PPP3CA PPP3CB PPP3CC CAPZB HNRNPCL2

9.57e-0783806int:CABIN1
InteractionLBH interactions

PPP3CA PPP3CB PPP3CC RBMXL1

1.92e-0623804int:LBH
InteractionSETSIP interactions

PPP3CA TRIM67 P3H1 CAPZB

2.73e-0625804int:SETSIP
InteractionRBMXL1 interactions

RBMXL2 HNRNPCL1 TRIM67 RBMXL1 RBMX DIDO1 HNRNPCL2

2.76e-06155807int:RBMXL1
InteractionANKRD50 interactions

TRIM67 RBMXL1 MYH14 PPP1R12A CAPZB DIDO1

4.49e-06108806int:ANKRD50
InteractionCALM3 interactions

RC3H2 PPP3CA TRIM67 PPP3CB PPP3CC PPP1R12A CAPZB DIDO1 ROS1

8.65e-06343809int:CALM3
InteractionSF1 interactions

CIRBP PPARGC1A RC3H2 TRIM67 RBMX ARHGAP12 WBP4 CAPZB

2.76e-05304808int:SF1
InteractionSH3BGRL interactions

HNRNPCL1 TRIM67 RBMXL1 MYH14 PPP1R12A CAPZB

3.16e-05152806int:SH3BGRL
InteractionRASSF2 interactions

PPP3CA TRIM67 PPP3CB SAV1

3.61e-0547804int:RASSF2
InteractionYTHDC1 interactions

ZXDC RC3H2 HNRNPCL1 TRIM67 RBMX ANKRD11 FTL HNRNPCL2 MAN1B1

4.04e-05417809int:YTHDC1
InteractionNEIL3 interactions

CIRBP ACACA RBMX ROCK1 FTL

4.21e-0597805int:NEIL3
InteractionMCM5 interactions

RBMXL2 HNRNPCL1 PPP3CA TRIM67 RBMXL1 RBMX KEAP1 NEK9 SDHA

4.27e-05420809int:MCM5
InteractionPRNP interactions

CIRBP MAGI2 PPP3CA TRIM67 PPP3CB TLN1 ARHGAP12 DUT CAPZB SAV1 PKP1 THTPA ROCK1 WDR12 MAN1B1

4.39e-0511588015int:PRNP
InteractionPPP3CB interactions

PPP3CA TRIM67 PPP3CB PPP3CC WDR12

4.42e-0598805int:PPP3CB
InteractionRCAN3 interactions

PPP3CA PPP3CB PPP3CC

4.71e-0518803int:RCAN3
InteractionFAM163B interactions

PPP3CA PPP3CB PPP3CC

4.71e-0518803int:FAM163B
InteractionGAGE5 interactions

RBMXL1 MYH14 PPP1R12A DIDO1

5.39e-0552804int:GAGE5
InteractionCIAO2A interactions

MYH11 MROH1 DERL1 PEX1 NEK9 MAN1B1

6.52e-05173806int:CIAO2A
InteractionSPATA33 interactions

PPP3CA PPP3CB PPP3CC

7.61e-0521803int:SPATA33
InteractionTSN interactions

PPP3CA TRIM67 P3H1 CAPZB WDR12

7.67e-05110805int:TSN
InteractionPPP3CA interactions

PPP3CA TRIM67 PPP3CB PPP3CC P3H1 RBMX

7.87e-05179806int:PPP3CA
InteractionBBS1 interactions

PPP1R12A WBP4 ROCK1 FTL KEAP1

8.01e-05111805int:BBS1
InteractionRBMX interactions

CIRBP RC3H2 RBMXL2 PPP3CA TRIM67 RBMXL1 RBMX CAPZB GFM2

8.73e-05461809int:RBMX
InteractionCRTC2 interactions

RC3H2 PPP3CA PPP3CB PPP3CC

1.01e-0461804int:CRTC2
InteractionRCAN2 interactions

PPP3CA PPP3CB PPP3CC

1.15e-0424803int:RCAN2
InteractionMYL9 interactions

MYH14 PPP1R12A MICB CAPZB

1.46e-0467804int:MYL9
InteractionARMT1 interactions

PPP3CA TRIM67 PPP3CB PPP3CC

1.46e-0467804int:ARMT1
InteractionNRDC interactions

PPP3CA TRIM67 P3H1 PPP1R12A GFM2

1.63e-04129805int:NRDC
InteractionPPP3R1 interactions

PPP3CA PPP3CB PPP3CC TRIM41

1.64e-0469804int:PPP3R1
InteractionCALM2 interactions

PPP3CA TRIM67 PPP3CB PPP3CC CAPZB DIDO1

1.70e-04206806int:CALM2
InteractionPLXNA4 interactions

HNRNPCL1 TRIM67 HNRNPCL2

1.84e-0428803int:PLXNA4
InteractionECT2 interactions

MYH11 RBMXL2 PPP3CA TRIM67 RBMXL1 MYH14 PPP1R12A RBMX CD109 CAPZB FTL HNRNPCL2

1.87e-048878012int:ECT2
InteractionKIF23 interactions

MYH11 RBMXL2 TRIM67 RBMXL1 MYH14 PPP1R12A RBMX CD109 CAPZB WDR12 UTP3 HNRNPCL2 SDHA

1.98e-0410318013int:KIF23
InteractionRPL36AL interactions

RC3H2 HNRNPCL1 TRIM67 TRIM41 CAPZB FTL UTP3

2.27e-04309807int:RPL36AL
Cytoband6q22

ROS1 DSE

8.76e-0588226q22
GeneFamilyProtein phosphatase catalytic subunits|EF-hand domain containing

PPP3CA PPP3CB PPP3CC

6.29e-0613523693
GeneFamilyRNA binding motif containing

CIRBP PPARGC1A RBMXL2 HNRNPCL1 RBMXL1 RBMX

3.23e-05213526725
GeneFamilyMyosin heavy chains

MYH11 MYH14

8.32e-04155221098
GeneFamilyFibronectin type III domain containing

TRIM67 ROS1 DCC CDON

1.15e-03160524555
CoexpressionGSE41978_ID2_KO_VS_ID2_KO_AND_BIM_KO_KLRG1_LOW_EFFECTOR_CD8_TCELL_UP

MYH11 CLCA1 PPP3CC MYH14 INMT PSMB6 PKP1

2.92e-06200817M9555
CoexpressionAtlasDevelopingGonad_e16.5_ovary_emap-9563_top-relative-expression-ranked_1000

MAGI2 RC3H2 CLCA1 TENM4 RNLS ATR RBMX PKD2 ANKRD11 DIDO1 ROCK1 CDON

4.60e-057958112gudmap_developingGonad_e16.5_ovary_1000
CoexpressionAtlasDevelopingGonad_e12.5_epididymis_emap-29139_top-relative-expression-ranked_1000

PPARGC1A MGAM RC3H2 CLCA1 TENM4 RBMX PKD2 ETS1 ANKRD11 DIDO1 ROCK1 PRDM1

5.26e-058068112gudmap_developingGonad_e12.5_epididymis_1000
CoexpressionAtlasDevelopingGonad_e12.5_epididymis_emap-29139_k-means-cluster#3_top-relative-expression-ranked_1000

PPARGC1A TENM4 RBMX PKD2 ANKRD11 DIDO1 PRDM1

5.97e-05259817gudmap_developingGonad_e12.5_epididymis_k3_1000
ToppCellfacs-Marrow-T-cells-3m-Lymphocytic-NK_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PPP3CC ETS1 WSCD2 DSE PRDM1

1.32e-05164825e712d6b89461f741dbd773ba9a27ecaddf97cbaa
ToppCellfacs-Diaphragm-Limb_Muscle-24m-Mesenchymal|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

INMT FTL CUBN DCC CDH6

1.70e-0517382566f37c1437705734b20601656fa4aa1d92ca30be
ToppCellfacs-Diaphragm-Limb_Muscle-24m-Mesenchymal-nan|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

INMT FTL CUBN DCC CDH6

1.70e-05173825649b08a409095592cccf31883be69c754411280d
ToppCelldroplet-Pancreas-Endocrine-21m-Epithelial-pancreatic_ductal_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MGAM INMT CP MMP11 CDH6

1.80e-05175825c1a8a55af825d5913095f919fa860828df9c273e
ToppCelldroplet-Pancreas-Endocrine-21m-Epithelial-pancreatic_ductal_cel|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MGAM INMT CP MMP11 CDH6

1.80e-0517582578b453e220218c84557f244ef7a760e4a1952761
ToppCellCOVID-19-kidney-Epi_(Mes)|COVID-19 / Disease (COVID-19 only), tissue and cell type

MAGI2 DCHS2 TENM4 WSCD2 CDH6

1.95e-05178825544379f5a6145429762258d426b876bb36c112f5
ToppCellfacs-Lung-18m-Mesenchymal-fibroblast-alveolar_fibroblast-alveolar_fibroblast_l1|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

MAGI2 INMT WSCD2 CP MMP11

2.12e-05181825ebf1ae963a2b22e1772752ed85a4fb0e546d377e
ToppCellRA-13._Vascular_Smooth_Muscle|RA / Chamber and Cluster_Paper

MYH11 PPP1R12A PKD2 ROCK1 CDH6

2.23e-05183825818fd886e0188091310825f9145fa53328f2c979
ToppCell5'-Adult-LymphNode-Mesenchymal-myocytic|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

MAGI2 MYH11 INMT PKD2 CDON

2.23e-05183825d67454baf0cf791a743b51afd1cb25bfb5765385
ToppCell5'-Adult-LymphNode-Mesenchymal-myocytic-myofibroblast_(RSPO2+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

MAGI2 MYH11 INMT PKD2 CDON

2.23e-05183825e49ac8314b6fe98426b1514ea68d646297b8bc0f
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PPARGC1A MGAM TENM4 ROS1 DCC

2.29e-051848252cbed6462fea2622871bb7e49b0df3d984239281
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PPARGC1A MGAM TENM4 ROS1 DCC

2.29e-05184825ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PPARGC1A MGAM TENM4 ROS1 DCC

2.29e-051848252b19a8c5f823e00812908b23e66bb4e563278aff
ToppCellSmart-seq2-spleen_(Smart-seq2)-lymphocytic-innate_lymphocytic|spleen_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

MGAM NOL4L PPP3CA ETS1 PRDM1

2.41e-05186825fc0b488c201a32d829047b58460297df2818b45d
ToppCellLA-13._Vascular_Smooth_Muscle|World / Chamber and Cluster_Paper

MYH11 PPP1R12A PKD2 ROCK1 CDH6

2.60e-051898256b3e88751b95fc2173f2c3d5061ed632d0c5f01c
ToppCellPND01|World / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CIRBP CLCA1 MYH14 INMT ANKRD11

2.88e-05193825c291345c11cfcbceacbdc001a5851f67478a2779
ToppCellPCW_05-06-Mesenchymal-Mesenchymal_fibroblastic|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

CIRBP MAGI2 TENM4 DCC CDON

2.95e-0519482585e00861c5068a27d0cf0ae677f420c8245baa9a
ToppCellTracheal-NucSeq-Immune_Lymphocytic-B-B_plasma-B_plasmablast|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

DERL1 MICB DNAJB7 DCC PRDM1

3.02e-05195825c6e31038be2463f1601d52c82efa4e9facb8228f
ToppCellParenchymal-NucSeq-Stromal-Myofibroblastic-Muscle_smooth_airway_ASM|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

MGAM MYH11 FRRS1L WSCD2 CDH6

3.25e-05198825d1827e3707b929e3a3562989a0c11537d344e164
ToppCellParenchymal-10x3prime_v2-Stromal-Myofibroblastic-Muscle_smooth_airway_ASM|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

MAGI2 MYH11 RBMXL1 VPS50 CDH6

3.25e-05198825cc2b5b632e73e44bb60050f0db10d8f0dbb859fa
DiseaseHepatic Form of Wilson Disease

PPP3CA PPP3CB CP

3.73e-0524803C1527352
DiseaseHepatolenticular Degeneration

PPP3CA PPP3CB CP

3.73e-0524803C0019202
Diseasecardiomyopathy (implicated_via_orthology)

PPP3CA PPP3CB PPP3CC SDHA

4.24e-0571804DOID:0050700 (implicated_via_orthology)
Diseasemelanoma

SLC5A5 ERCC4 CP ROS1 CUBN DCC

5.93e-05248806C0025202
DiseaseIron Metabolism Disorders

CP FTL

7.22e-055802C0012715
Diseasefocal segmental glomerulosclerosis (is_marker_for)

PPP3CA PPP3CB

2.01e-048802DOID:1312 (is_marker_for)
Diseaseschizophrenia (is_marker_for)

PPP3CA PPP3CB PPP3CC

2.35e-0444803DOID:5419 (is_marker_for)
Diseaseegg allergy measurement

ERCC4 ABCB11

2.58e-049802EFO_0007018
DiseaseNeurodegeneration with brain iron accumulation

CP FTL

5.55e-0413802cv:C2931845
DiseaseNonorganic psychosis

TENM4 PPP3CC FTL

8.84e-0469803C0349204
DiseaseHoloprosencephaly

PPP1R12A CDON

9.61e-0417802C0079541
Diseaseresponse to ziprasidone

PPP3CA TENM4

1.34e-0320802GO_0097337
DiseaseRetinal Degeneration

CP IFT80

1.47e-0321802C0035304
DiseaseGlioma

SLC5A5 ATR ROS1

1.73e-0387803C0017638
DiseaseFEV/FEC ratio

PPARGC1A MGAM DCHS2 NOL4L RNLS ARHGAP12 CAPZB ANKRD11 DCC CDON

1.76e-0312288010EFO_0004713
DiseaseAdenocarcinoma of lung (disorder)

PPP3CA ATR ROS1 KEAP1

2.41e-03206804C0152013
Diseasehyperthyroidism (biomarker_via_orthology)

PPARGC1A CP

2.62e-0328802DOID:7998 (biomarker_via_orthology)
DiseasePsychotic Disorders

TENM4 PPP3CC FTL

2.64e-03101803C0033975
DiseaseSchizophrenia

MAGI2 PPARGC1A TENM4 PPP3CC MICB CP DCC SDHA

2.70e-03883808C0036341

Protein segments in the cluster

PeptideGeneStartEntry
YAEYVTYTGSYLLDG

ANKRD11

2466

Q6UB99
NSASYRYGGYLISNE

ABCB11

996

O95342
GTVEYLYSQDGSFYF

ACACA

421

Q13085
DVLGRSFLYNYEYLG

DNHD1

1641

Q96M86
QYRDLYFEGGVSSVY

CAPZB

106

P47756
FSSNLDLRYGGDYDS

ASTE1

41

Q2TB18
SLRERYNSLDGYYSV

RC3H2

731

Q9HBD1
GSSRYDDYSSSRDGY

RBMX

306

P38159
AYTFRDYSAILYLNG

P3H1

606

Q32P28
SSYIYGYVDATYREG

PSMB6

166

P28072
QSEDSTFYLGERTYY

CP

721

P00450
RYLLYYYSDSDKGQG

IGLV5-37

66

A0A075B6J1
FTEYSLRFLAYNRYG

DCC

591

P43146
GSSFDLDYGFQRDYY

HNRNPCL1

106

O60812
ALLESGTYEDNYYGT

MAGI2

171

Q86UL8
GSSFDLDYGFQRDYY

HNRNPCL2

106

B2RXH8
VTDEGQLYAFGSDYY

NEK9

441

Q8TD19
LPRDYLATYYSFDGS

INMT

16

O95050
TQADFRLYGSDYSVY

ENTPD8

226

Q5MY95
QASYTYLSLGFYFDR

FTL

26

P02792
YLYGFGETEHTSYRR

MGAM

2026

O43451
ESRYTSDYFISYGIE

ETS1

151

P14921
RERYYSGLIYTYSGL

MYH14

126

Q7Z406
LYFLYQYSTRLETGA

DERL1

76

Q9BUN8
VGFATAYDFLYNYLS

DSE

156

Q9UL01
STRGSRHFYYDGELF

MICB

126

Q29980
SPYNLYFYSLDSSGN

PLEKHM3

236

Q6ZWE6
ARAAGYDLYSAYDYT

DUT

131

P33316
LNYSYRGYGALSSNL

NOL4L

336

Q96MY1
YLQLGYEGFSRDYRD

MROH1

996

Q8NDA8
FTLGARADSYYEYLL

MAN1B1

456

Q9UKM7
QGRQYYYSADGSRSE

ARHGAP12

371

Q8IWW6
GFIEYSLYDGFLSYE

DCHS2

696

Q6V1P9
RDDGDSYGFITYRYT

PPARGC1A

711

Q9UBK2
NYYTDFLEIRDGGYE

CUBN

1101

O60494
SYGNRNRDAGYFFST

DNAJB7

126

Q7Z6W7
AASFERGSYQRGYEY

ATR

1836

Q13535
LYQREDGSFSAFGNY

CD109

966

Q6YHK3
YSGLQYFLRRGDYAD

CRYGD

51

P07320
GSSIYLYSYEGRFIS

IFT80

391

Q9P2H3
SSYGTFAGEFYDLRY

FRRS1L

61

Q9P0K9
GFYIYYRPTDSDNDS

CDON

861

Q4KMG0
VAYISLYSYFSSRGR

DIDO1

1131

Q9BTC0
AGGYFRQSLSYLEAY

KEAP1

331

Q14145
FLLEEYTGSDYQYVG

CDH6

61

P55285
RYLFLGDYVDRGYFS

PPP3CB

121

P16298
YYDTDYGSKSRGRQS

UTP3

136

Q9NQZ2
YRLYFGSSYESELGN

PEX1

1126

O43933
TRYLFLGDYVDRGYF

PPP3CA

111

Q08209
QDADGYAYFLRGRLY

MMP11

441

P24347
YDGLADNYNYGTTSR

PKP1

71

Q13835
VYLDYEAGRLGFYNA

TRIM41

581

Q8WV44
LYYSGYTRSLGDVDD

GFM2

91

Q969S9
GSSRYDDYSSSRDGY

RBMXL1

306

Q96E39
GRSLRYDTSYFVEYF

SDHA

206

P31040
EELSYDYSGRYLNLT

SETMAR

256

Q53H47
RDSYAYLNASYGTEG

PRDM1

371

O75626
DEGYSSRDGYSSRDY

RBMXL2

211

O75526
YSDRSSGGSYRDSYD

CIRBP

151

Q14011
GVYSRYFTTYDTNGR

CLCA1

656

A8K7I4
RERYFSGLIYTYSGL

MYH11

106

P35749
SFAVENGDSGSRYYY

SAV1

121

Q9H4B6
NTRYLFLGDYVDRGY

PPP3CC

106

P48454
YLYAIYTFFGRNDSL

VPS50

646

Q96JG6
KLSLYSETDSGYGSY

TRIM67

101

Q6ZTA4
YSYGQSAAARSYEDR

ZFR2

91

Q9UPR6
NFYLESGGSARTDYR

ZXDC

706

Q2QGD7
DSFYAISYLYYGALG

SLC5A5

521

Q92911
EAVSYSSRYALGLFY

RNLS

186

Q5VYX0
FTLDFGDYQDGYYSV

TLN1

366

Q9Y490
EGLSEDGFTYYYNTE

WBP4

171

O75554
DGFTYYYNTETGESR

WBP4

176

O75554
SDGSSYIIDYYGTRL

TM2D1

176

Q9BX74
GGTLEYRVTFRDTYY

THTPA

26

Q9BU02
YLYNFTYTGDGDITL

TENM4

1606

Q6N022
ADSYNGYVFYLLRDG

ROS1

416

P08922
DSDFFTSYYTLGNIY

TTC17

291

Q96AE7
YSGAGYYLDLSRTRE

PKD2

386

Q13563
GFTYYSNRRYLSSAN

ROCK1

396

Q13464
YFLIYGGSTEEQRYL

ERCC4

606

Q92889
LSGGADNKLYSYRYS

WDR12

401

Q9GZL7
IELATGFYTGSYYFD

WSCD2

361

Q2TBF2
YDSLLGRSGSYSYLE

PPP1R12A

901

O14974