Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	ATP-dependent chromatin remodeler activity	SMARCA2 CHD9 CHD8 CHD6	1.90e-05	37	86	4	GO:0140658
GeneOntologyMolecularFunction	coumarin 7-hydroxylase activity	CYP2A6 CYP2A13	5.48e-05	3	86	2	GO:0008389
GeneOntologyMolecularFunction	arachidonate monooxygenase activity	CYP1A1 CYP2A6 CYP2A13	2.09e-04	27	86	3	GO:0008391
GeneOntologyMolecularFunction	steroid hydroxylase activity	CYP1A1 CYP2A6 CYP2A13	4.19e-04	34	86	3	GO:0008395
GeneOntologyMolecularFunction	aromatase activity	CYP1A1 CYP2A6 CYP2A13	4.57e-04	35	86	3	GO:0070330
GeneOntologyMolecularFunction	helicase activity	SMARCA2 CHD9 CHD8 CHD6 DDX4	6.05e-04	158	86	5	GO:0004386
GeneOntologyMolecularFunction	ATP hydrolysis activity	KIF21B ABCB10 ABCB11 CHD9 CHD8 CHD6 ATP10A DDX4	6.26e-04	441	86	8	GO:0016887
GeneOntologyBiologicalProcess	porphyrin-containing compound metabolic process	CYP1A1 CYP2A6 CYP2A13 RSAD1 ABCB10	6.15e-06	63	85	5	GO:0006778
GeneOntologyBiologicalProcess	phenylpropanoid metabolic process	CYP1A1 CYP2A6 CYP2A13	7.94e-06	10	85	3	GO:0009698
GeneOntologyBiologicalProcess	coumarin metabolic process	CYP1A1 CYP2A6 CYP2A13	7.94e-06	10	85	3	GO:0009804
GeneOntologyBiologicalProcess	tetrapyrrole metabolic process	CYP1A1 CYP2A6 CYP2A13 RSAD1 ABCB10	1.27e-05	73	85	5	GO:0033013
GeneOntologyBiologicalProcess	epoxygenase P450 pathway	CYP1A1 CYP2A6 CYP2A13	9.83e-05	22	85	3	GO:0019373
GeneOntologyCellularComponent	Z disc	PRICKLE4 SPTAN1 SYNE2 OBSCN MYO18B	4.22e-04	151	87	5	GO:0030018
GeneOntologyCellularComponent	sarcomere	PRICKLE4 HABP4 SPTAN1 SYNE2 OBSCN MYO18B	6.07e-04	249	87	6	GO:0030017
GeneOntologyCellularComponent	I band	PRICKLE4 SPTAN1 SYNE2 OBSCN MYO18B	6.50e-04	166	87	5	GO:0031674
GeneOntologyCellularComponent	FNIP-folliculin RagC/D GAP	FNIP2 LAMTOR4	7.54e-04	10	87	2	GO:1990877
GeneOntologyCellularComponent	GTPase activator complex	FNIP2 LAMTOR4	9.19e-04	11	87	2	GO:1902773
GeneOntologyCellularComponent	myofibril	PRICKLE4 HABP4 SPTAN1 SYNE2 OBSCN MYO18B	9.79e-04	273	87	6	GO:0030016
GeneOntologyCellularComponent	fascia adherens	DSP SPTAN1	1.30e-03	13	87	2	GO:0005916
GeneOntologyCellularComponent	sarcoplasm	HABP4 SYNE2 H6PD JPH3	1.32e-03	114	87	4	GO:0016528
GeneOntologyCellularComponent	contractile muscle fiber	PRICKLE4 HABP4 SPTAN1 SYNE2 OBSCN MYO18B	1.33e-03	290	87	6	GO:0043292
MousePheno	dilated heart right atrium	JARID2 SPEG MYO18B	2.67e-05	12	71	3	MP:0004062
MousePheno	increased thigmotaxis	ATG2B PEPD LRP5 CHD8 CHD6 SON	5.48e-05	132	71	6	MP:0002797
Domain	BRK	SMARCA2 CHD9 CHD8 CHD6	6.54e-09	6	87	4	SM00592
Domain	BRK_domain	SMARCA2 CHD9 CHD8 CHD6	6.54e-09	6	87	4	IPR006576
Domain	BRK	SMARCA2 CHD9 CHD8 CHD6	6.54e-09	6	87	4	PF07533
Domain	SNF2_N	SMARCA2 CHD9 CHD8 CHD6	1.43e-05	32	87	4	IPR000330
Domain	SNF2_N	SMARCA2 CHD9 CHD8 CHD6	1.43e-05	32	87	4	PF00176
Domain	Runt	RUNX2 RUNX3	6.42e-05	3	87	2	PF00853
Domain	Runt_dom	RUNX2 RUNX3	6.42e-05	3	87	2	IPR013524
Domain	RunxI_C_dom	RUNX2 RUNX3	6.42e-05	3	87	2	IPR013711
Domain	RUNT	RUNX2 RUNX3	6.42e-05	3	87	2	PS51062
Domain	Runx_central_dom	RUNX2 RUNX3	6.42e-05	3	87	2	IPR027384
Domain	-	RUNX2 RUNX3	6.42e-05	3	87	2	4.10.770.10
Domain	TF_Runt-rel_RUNX	RUNX2 RUNX3	6.42e-05	3	87	2	IPR016554
Domain	RunxI	RUNX2 RUNX3	6.42e-05	3	87	2	PF08504
Domain	AML1_Runt	RUNX2 RUNX3	6.42e-05	3	87	2	IPR000040
Domain	Cyt_P450_E_grp-I_CYP2A-like	CYP2A6 CYP2A13	1.28e-04	4	87	2	IPR008067
Domain	Helicase_C	SMARCA2 CHD9 CHD8 CHD6 DDX4	1.43e-04	107	87	5	PF00271
Domain	HELICc	SMARCA2 CHD9 CHD8 CHD6 DDX4	1.43e-04	107	87	5	SM00490
Domain	Helicase_C	SMARCA2 CHD9 CHD8 CHD6 DDX4	1.49e-04	108	87	5	IPR001650
Domain	HELICASE_CTER	SMARCA2 CHD9 CHD8 CHD6 DDX4	1.56e-04	109	87	5	PS51194
Domain	HELICASE_ATP_BIND_1	SMARCA2 CHD9 CHD8 CHD6 DDX4	1.56e-04	109	87	5	PS51192
Domain	DEXDc	SMARCA2 CHD9 CHD8 CHD6 DDX4	1.56e-04	109	87	5	SM00487
Domain	Helicase_ATP-bd	SMARCA2 CHD9 CHD8 CHD6 DDX4	1.63e-04	110	87	5	IPR014001
Domain	Chromo_domain	CHD9 CHD8 CHD6	1.84e-04	24	87	3	IPR023780
Domain	tRNA-bd_arm	DSP CROCC TRAK1	1.84e-04	24	87	3	IPR010978
Domain	Chromo	CHD9 CHD8 CHD6	2.35e-04	26	87	3	PF00385
Domain	CHROMO_1	CHD9 CHD8 CHD6	2.94e-04	28	87	3	PS00598
Domain	CHROMO_2	CHD9 CHD8 CHD6	2.94e-04	28	87	3	PS50013
Domain	p53/RUNT-type_TF_DNA-bd	RUNX2 RUNX3	3.18e-04	6	87	2	IPR012346
Domain	-	RUNX2 RUNX3	3.18e-04	6	87	2	2.60.40.720
Domain	Spectrin_repeat	DSP SPTAN1 SYNE2	3.27e-04	29	87	3	IPR002017
Domain	Spectrin/alpha-actinin	DSP SPTAN1 SYNE2	4.39e-04	32	87	3	IPR018159
Domain	Chromodomain-like	CHD9 CHD8 CHD6	4.39e-04	32	87	3	IPR016197
Domain	SPEC	DSP SPTAN1 SYNE2	4.39e-04	32	87	3	SM00150
Domain	Glyco_hydro/deAcase_b/a-brl	ST6GAL2 MAN2A2	4.44e-04	7	87	2	IPR011330
Domain	Chromo/shadow_dom	CHD9 CHD8 CHD6	4.81e-04	33	87	3	IPR000953
Domain	CHROMO	CHD9 CHD8 CHD6	4.81e-04	33	87	3	SM00298
Domain	RRM	CIRBP ESRP2 RBM3 ESRP1 LARP4 RBM34	5.30e-04	217	87	6	SM00360
Domain	RRM_dom	CIRBP ESRP2 RBM3 ESRP1 LARP4 RBM34	6.71e-04	227	87	6	IPR000504
Domain	RRM	CIRBP ESRP2 RBM3 ESRP1 LARP4 RBM34	7.19e-04	230	87	6	PS50102
Domain	fn3	IL12RB1 SDK2 EPHA2 SPEG OBSCN	9.62e-04	162	87	5	PF00041
Domain	-	CIRBP ESRP2 RBM3 ESRP1 LARP4 RBM34	9.77e-04	244	87	6	3.30.70.330
Domain	Cyt_P450_E_grp-I	CYP1A1 CYP2A6 CYP2A13	1.20e-03	45	87	3	IPR002401
Domain	Nucleotide-bd_a/b_plait	CIRBP ESRP2 RBM3 ESRP1 LARP4 RBM34	1.30e-03	258	87	6	IPR012677
Domain	FN3	IL12RB1 SDK2 EPHA2 SPEG OBSCN	1.73e-03	185	87	5	SM00060
Domain	Cyt_P450_CS	CYP1A1 CYP2A6 CYP2A13	1.93e-03	53	87	3	IPR017972
Domain	FN3	IL12RB1 SDK2 EPHA2 SPEG OBSCN	2.38e-03	199	87	5	PS50853
Domain	CYTOCHROME_P450	CYP1A1 CYP2A6 CYP2A13	2.38e-03	57	87	3	PS00086
Domain	-	CYP1A1 CYP2A6 CYP2A13	2.50e-03	58	87	3	1.10.630.10
Domain	p450	CYP1A1 CYP2A6 CYP2A13	2.50e-03	58	87	3	PF00067
Domain	Cyt_P450	CYP1A1 CYP2A6 CYP2A13	2.76e-03	60	87	3	IPR001128
Domain	RRM_1	CIRBP ESRP2 RBM3 ESRP1 RBM34	2.88e-03	208	87	5	PF00076
Domain	FN3_dom	IL12RB1 SDK2 EPHA2 SPEG OBSCN	2.94e-03	209	87	5	IPR003961
Domain	Kinase-like_dom	TAOK2 EPHA2 SPEG OBSCN CHD9 ACAD10 TP53RK ERN2	3.75e-03	542	87	8	IPR011009
Domain	PWWP	NSD2 BRD1	3.86e-03	20	87	2	SM00293
Domain	Prefoldin	KIF21B DSP CROCC	4.62e-03	72	87	3	IPR009053
Pathway	REACTOME_XENOBIOTICS	CYP1A1 CYP2A6 CYP2A13	1.55e-04	23	65	3	M5372
Pathway	REACTOME_XENOBIOTICS	CYP1A1 CYP2A6 CYP2A13	2.00e-04	25	65	3	MM14846
Pathway	KEGG_MEDICUS_ENV_FACTOR_NNK_TO_DNA_ADDUCTS	CYP2A6 CYP2A13	2.07e-04	5	65	2	M47808
Pathway	KEGG_RETINOL_METABOLISM	CYP1A1 CYP2A6 CYP2A13 DHRS3	2.13e-04	64	65	4	M9488
Pathway	REACTOME_RUNX3_REGULATES_CDKN1A_TRANSCRIPTION	ZFHX3 RUNX3	3.10e-04	6	65	2	MM15534
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	DHRS3 NSD2 PPP1R9A NAT10 PEPD OBSCN SMARCA2 LRP5 CHD9 ZFHX3 CHD6 H6PD PALS2 CROCC GALNT7 LARP4 ATP10A	2.03e-07	1489	89	17	28611215
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	DSP NSD2 SPTAN1 SYNE2 NAT10 SMARCA2 BOP1 CHD8 LARP4 RBM34 SON	9.12e-07	653	89	11	22586326
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	FNIP2 TENM4 SPEG PPP1R9A TCF25 CHD6 CROCC TRAK1 SON	1.05e-06	407	89	9	12693553
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	TAOK2 KIF21B ST6GAL2 SDK2 NSD2 NAT10 BOP1 CHD8 FRMD4B IGSF3	1.06e-06	529	89	10	14621295
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	TAOK2 CIRBP JARID2 HABP4 PDCD6 NSD2 RBM3 PPP1R9A SMARCA2 BUD13 BOP1 ZFHX3 CHD8 CHD6 CROCC SON	1.16e-06	1497	89	16	31527615
Pubmed	A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.	MAN2A2 LAMTOR4 DSP SYNE2 OBSCN LAMA4 TP53RK MYO18B SON	5.34e-06	497	89	9	23414517
Pubmed	Novel DNA sequence variations of cytochrome P450 genes in the Han Chinese population.	CYP1A1 CYP2A6 CYP2A13	5.78e-06	14	89	3	19290787
Pubmed	Epithelial splicing regulatory proteins 1 (ESRP1) and 2 (ESRP2) suppress cancer cell motility via different mechanisms.	ESRP2 ESRP1	6.48e-06	2	89	2	25143390
Pubmed	The epithelial splicing factors ESRP1 and ESRP2 positively and negatively regulate diverse types of alternative splicing events.	ESRP2 ESRP1	6.48e-06	2	89	2	19829082
Pubmed	Dual Roles for Epithelial Splicing Regulatory Proteins 1 (ESRP1) and 2 (ESRP2) in Cancer Progression.	ESRP2 ESRP1	6.48e-06	2	89	2	27401076
Pubmed	Functional relevance of the BMD-associated polymorphism rs312009: novel involvement of RUNX2 in LRP5 transcriptional regulation.	LRP5 RUNX2	6.48e-06	2	89	2	21542013
Pubmed	Evaluation of inhibition selectivity for human cytochrome P450 2A enzymes.	CYP2A6 CYP2A13	6.48e-06	2	89	2	22696418
Pubmed	Suppressed hepatocyte proliferation via a ROS-HNE-P21 pathway is associated with nicotine- and cotinine-enhanced alcoholic fatty liver in mice.	CYP2A6 CYP2A13	6.48e-06	2	89	2	30876690
Pubmed	CYP2A5 induction and hepatocellular stress: an adaptive response to perturbations of heme homeostasis.	CYP2A6 CYP2A13	6.48e-06	2	89	2	21395539
Pubmed	Orthologous relationship of obscurin and Unc-89: phylogeny of a novel family of tandem myosin light chain kinases.	SPEG OBSCN	6.48e-06	2	89	2	15185077
Pubmed	Species differences in coumarin metabolism: a molecular modelling evaluation of CYP2A interactions.	CYP2A6 CYP2A13	6.48e-06	2	89	2	12162851
Pubmed	Molecular characterization of the murine Coh locus: an amino acid difference at position 117 confers high and low coumarin 7-hydroxylase activity in P450coh.	CYP2A6 CYP2A13	6.48e-06	2	89	2	1302041
Pubmed	Structural alteration of mouse P450coh by mutation of glycine-207 to proline: spin equilibrium, enzyme kinetics, and heat sensitivity.	CYP2A6 CYP2A13	6.48e-06	2	89	2	8395817
Pubmed	Genome-wide determination of a broad ESRP-regulated posttranscriptional network by high-throughput sequencing.	ESRP2 ESRP1	6.48e-06	2	89	2	22354987
Pubmed	Tumor suppressor, AT motif binding factor 1 (ATBF1), translocates to the nucleus with runt domain transcription factor 3 (RUNX3) in response to TGF-beta signal transduction.	ZFHX3 RUNX3	6.48e-06	2	89	2	20599712
Pubmed	Absence of cytochrome P450 2A5 enhances alcohol-induced liver injury in mice.	CYP2A6 CYP2A13	6.48e-06	2	89	2	25804444
Pubmed	Effect of pyrazole, cobalt and phenobarbital on mouse liver cytochrome P-450 2a-4/5 (Cyp2a-4/5) expression.	CYP2A6 CYP2A13	6.48e-06	2	89	2	1520280
Pubmed	Role of CYP2A13 in the bioactivation and lung tumorigenicity of the tobacco-specific lung procarcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone: in vivo studies using a CYP2A13-humanized mouse model.	CYP2A6 CYP2A13	6.48e-06	2	89	2	23917075
Pubmed	Nicotine enhances alcoholic fatty liver in mice: Role of CYP2A5.	CYP2A6 CYP2A13	6.48e-06	2	89	2	30222954
Pubmed	Up-regulation of CYP2A5 expression by porphyrinogenic agents in mouse liver.	CYP2A6 CYP2A13	6.48e-06	2	89	2	7543189
Pubmed	Genomic Landscape of Experimental Bladder Cancer in Rodents and Its Application to Human Bladder Cancer: Gene Amplification and Potential Overexpression of Cyp2a5/CYP2A6 Are Associated with the Invasive Phenotype.	CYP2A6 CYP2A13	6.48e-06	2	89	2	27902773
Pubmed	An ESRP-regulated splicing programme is abrogated during the epithelial-mesenchymal transition.	ESRP2 ESRP1	6.48e-06	2	89	2	20711167
Pubmed	Cytochrome P2A13 and P1A1 gene polymorphisms are associated with the occurrence of uterine leiomyoma.	CYP1A1 CYP2A13	6.48e-06	2	89	2	16835796
Pubmed	Lung cancer risk in relation to nicotinic acetylcholine receptor, CYP2A6 and CYP1A1 genotypes in the Bangladeshi population.	CYP1A1 CYP2A6	6.48e-06	2	89	2	23178447
Pubmed	Characterization and regulation of sex-specific mouse steroid hydroxylase genes.	CYP2A6 CYP2A13	6.48e-06	2	89	2	2372744
Pubmed	Metabolic effects of CYP2A6 and CYP2A13 on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-induced gene mutation--a mammalian cell-based mutagenesis approach.	CYP2A6 CYP2A13	6.48e-06	2	89	2	21473878
Pubmed	Oxygen-regulated expression of the RNA-binding proteins RBM3 and CIRP by a HIF-1-independent mechanism.	CIRBP RBM3	6.48e-06	2	89	2	15075239
Pubmed	The CYP2A gene subfamily: species differences, regulation, catalytic activities and role in chemical carcinogenesis.	CYP2A6 CYP2A13	6.48e-06	2	89	2	7581481
Pubmed	Circadian Regulation of Hepatic Cytochrome P450 2a5 by Peroxisome Proliferator-Activated Receptor γ.	CYP2A6 CYP2A13	6.48e-06	2	89	2	30154104
Pubmed	Identification of sequence variants influencing immunoglobulin levels.	RUNX2 RUNX3	6.48e-06	2	89	2	28628107
Pubmed	Downregulated ESRP1/2 promotes lung metastasis of bladder carcinoma through altering FGFR2 splicing and macrophage polarization.	ESRP2 ESRP1	6.48e-06	2	89	2	37090731
Pubmed	Interstrain differences in the expression and activity of Cyp2a5 in the mouse liver.	CYP2A6 CYP2A13	6.48e-06	2	89	2	28298240
Pubmed	Genetic polymorphisms for a phenobarbital-inducible cytochrome P-450 map to the Coh locus in mice.	CYP2A6 CYP2A13	6.48e-06	2	89	2	6309775
Pubmed	Chronic social stress blunts core body temperature and molecular rhythms of Rbm3 and Cirbp in mouse lateral habenula.	CIRBP RBM3	6.48e-06	2	89	2	37463657
Pubmed	Mechanism-based inhibition of cytochrome P450 (CYP)2A6 by chalepensin in recombinant systems, in human liver microsomes and in mice in vivo.	CYP2A6 CYP2A13	6.48e-06	2	89	2	21418183
Pubmed	The global Protein-RNA interaction map of ESRP1 defines a post-transcriptional program that is essential for epithelial cell function.	ESRP2 ESRP1	6.48e-06	2	89	2	36238894
Pubmed	Role of CYP2A5 in the bioactivation of the lung carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in mice.	CYP2A6 CYP2A13	6.48e-06	2	89	2	22262919
Pubmed	Modulation of cytochrome P450 2A5 activity by lipopolysaccharide: low-dose effects and non-monotonic dose-response relationship.	CYP2A6 CYP2A13	6.48e-06	2	89	2	25635819
Pubmed	Down-regulating cold shock protein genes impairs cancer cell survival and enhances chemosensitivity.	CIRBP RBM3	6.48e-06	2	89	2	19277990
Pubmed	Genetic variation between mice in their metabolism of coumarin and its derivatives.	CYP2A6 CYP2A13	6.48e-06	2	89	2	566237
Pubmed	Epithelial splicing regulatory protein 1 and 2 (ESRP1 and ESRP2) upregulation predicts poor prognosis in prostate cancer.	ESRP2 ESRP1	6.48e-06	2	89	2	33339518
Pubmed	Role of CYP2A5 in the clearance of nicotine and cotinine: insights from studies on a Cyp2a5-null mouse model.	CYP2A6 CYP2A13	6.48e-06	2	89	2	19923441
Pubmed	Effects of lipopolysaccharide-stimulated inflammation and pyrazole-mediated hepatocellular injury on mouse hepatic Cyp2a5 expression.	CYP2A6 CYP2A13	6.48e-06	2	89	2	12499123
Pubmed	Identification and characterization of a 44 kDa protein that binds specifically to the 3'-untranslated region of CYP2a5 mRNA: inducibility, subcellular distribution and possible role in mRNA stabilization.	CYP2A6 CYP2A13	6.48e-06	2	89	2	8611142
Pubmed	Function and regulation of the Cyp2a5/CYP2A6 genes in response to toxic insults in the liver.	CYP2A6 CYP2A13	6.48e-06	2	89	2	22497566
Pubmed	High glucose-ROS conditions enhance the progression in cholangiocarcinoma via upregulation of MAN2A2 and CHD8.	MAN2A2 CHD8	6.48e-06	2	89	2	33141432
Pubmed	Coumarin toxicity in different strains of mice.	CYP2A6 CYP2A13	6.48e-06	2	89	2	665441
Pubmed	Effects of moderate and deep hypothermia on RNA-binding proteins RBM3 and CIRP expressions in murine hippocampal brain slices.	CIRBP RBM3	6.48e-06	2	89	2	23415676
Pubmed	Ablation of the epithelial-specific splicing factor Esrp1 results in ureteric branching defects and reduced nephron number.	ESRP2 ESRP1	6.48e-06	2	89	2	27404344
Pubmed	Essential role of the cytochrome P450 enzyme CYP2A5 in olfactory mucosal toxicity of naphthalene.	CYP2A6 CYP2A13	6.48e-06	2	89	2	24104196
Pubmed	Expression of RNA-binding Motif Protein 3 (RBM3) and Cold-inducible RNA-binding protein (CIRP) Is Associated with Improved Clinical Outcome in Patients with Colon Cancer.	CIRBP RBM3	6.48e-06	2	89	2	28373441
Pubmed	The role of CYP2A5 in liver injury and fibrosis: chemical-specific difference.	CYP2A6 CYP2A13	6.48e-06	2	89	2	26363552
Pubmed	Mouse liver P450Coh: genetic regulation of the pyrazole-inducible enzyme and comparison with other P450 isoenzymes.	CYP2A6 CYP2A13	6.48e-06	2	89	2	2712571
Pubmed	Early life environment, neurodevelopment and the interrelation with atopy.	CYP1A1 NAT1 CYP2A6	8.86e-06	16	89	3	20701904
Pubmed	TWIST1 and chromatin regulatory proteins interact to guide neural crest cell differentiation.	NSD2 CHD9 BOP1 CHD8 CHD6	9.28e-06	109	89	5	33554859
Pubmed	HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation.	TAOK2 CIRBP HABP4 MAN2A2 PDCD6 DSP RBM3 EPHA2 SPTAN1 NAT10 BOP1 LARP4 RBM34 SON	9.85e-06	1371	89	14	36244648
Pubmed	Molecular genetics of the human cytochrome P450 monooxygenase superfamily.	CYP1A1 CYP2A6 CYP2A13	1.79e-05	20	89	3	9890157
Pubmed	Risk of malignant pleural mesothelioma and polymorphisms in genes involved in the genome stability and xenobiotics metabolism.	CYP1A1 NAT1 CYP2A6	1.79e-05	20	89	3	19751749
Pubmed	Coactivator PGC-1alpha regulates the fasting inducible xenobiotic-metabolizing enzyme CYP2A5 in mouse primary hepatocytes.	CYP2A6 CYP2A13	1.94e-05	3	89	2	18602936
Pubmed	TRPV4-dependent induction of a novel mammalian cold-inducible protein SRSF5 as well as CIRP and RBM3.	CIRBP RBM3	1.94e-05	3	89	2	28536481
Pubmed	Pharmacogenomics of maternal tobacco use: metabolic gene polymorphisms and risk of adverse pregnancy outcomes.	CYP1A1 CYP2A6	1.94e-05	3	89	2	20177288
Pubmed	Expression of cytochrome P450 2A5 in a glucose-6-phosphate dehydrogenase-deficient mouse model of oxidative stress.	CYP2A6 CYP2A13	1.94e-05	3	89	2	18068688
Pubmed	Regulation of bile acid metabolism in mouse models with hydrophobic bile acid composition.	CYP2A6 CYP2A13	1.94e-05	3	89	2	31645370
Pubmed	Rip locus: regulation of female-specific isozyme (I-P-450(16 alpha) of testosterone 16 alpha-hydroxylase in mouse liver, chromosome localization, and cloning of P-450 cDNA.	CYP2A6 CYP2A13	1.94e-05	3	89	2	3219345
Pubmed	Expression of Runx1, -2 and -3 during tooth, palate and craniofacial bone development.	RUNX2 RUNX3	1.94e-05	3	89	2	14516670
Pubmed	Reciprocal regulation of sex-dependent expression of testosterone 15 alpha-hydroxylase (P-450(15 alpha)) in liver and kidney of male mice by androgen. Evidence for a single gene.	CYP2A6 CYP2A13	1.94e-05	3	89	2	3346244
Pubmed	Zfp30, a KRAB domain containing zinc finger protein gene, maps to mouse chromosome 7.	CYP2A6 CYP2A13	1.94e-05	3	89	2	7849402
Pubmed	Mechanisms of olfactory toxicity of the herbicide 2,6-dichlorobenzonitrile: essential roles of CYP2A5 and target-tissue metabolic activation.	CYP2A6 CYP2A13	1.94e-05	3	89	2	20840855
Pubmed	Alteration of mouse cytochrome P450coh substrate specificity by mutation of a single amino-acid residue.	CYP2A6 CYP2A13	1.94e-05	3	89	2	2733794
Pubmed	Ethanol induction of CYP2A5: role of CYP2E1-ROS-Nrf2 pathway.	CYP2A6 CYP2A13	1.94e-05	3	89	2	22552773
Pubmed	A trans-acting locus regulates transcriptional repression of the female-specific steroid 15 alpha-hydroxylase gene in male mice.	CYP2A6 CYP2A13	1.94e-05	3	89	2	8297477
Pubmed	Lack of the steroid 15 alpha-hydroxylase gene (Cyp2a-4) in wild mouse strain Mus spretus: rapid evolution of the P450 gene superfamily.	CYP2A6 CYP2A13	1.94e-05	3	89	2	8188299
Pubmed	Site-directed mutagenesis of mouse steroid 7 alpha-hydroxylase (cytochrome P-450(7) alpha): role of residue-209 in determining steroid-cytochrome P-450 interaction.	CYP2A6 CYP2A13	1.94e-05	3	89	2	8484736
Pubmed	Limited heme synthesis in porphobilinogen deaminase-deficient mice impairs transcriptional activation of specific cytochrome P450 genes by phenobarbital.	CYP2A6 CYP2A13	1.94e-05	3	89	2	11106424
Pubmed	Comparison of hamster and mouse reveals interspecies differences in the regulation of hepatic CYP2A isozymes.	CYP2A6 CYP2A13	1.94e-05	3	89	2	8250953
Pubmed	Regulation of CYP2A5 gene by the transcription factor nuclear factor (erythroid-derived 2)-like 2.	CYP2A6 CYP2A13	1.94e-05	3	89	2	17303623
Pubmed	Runx2 and Runx3 differentially regulate articular chondrocytes during surgically induced osteoarthritis development.	RUNX2 RUNX3	1.94e-05	3	89	2	36261443
Pubmed	The structure and characterization of type I P-450(15) alpha gene as major steroid 15 alpha-hydroxylase and its comparison with type II P-450(15) alpha gene.	CYP2A6 CYP2A13	1.94e-05	3	89	2	2703500
Pubmed	Cerium-induced strain-dependent increase in Cyp2a-4/5 (cytochrome P4502a-4/5) expression in the liver and kidneys of inbred mice.	CYP2A6 CYP2A13	1.94e-05	3	89	2	1417950
Pubmed	Impact of nicotine metabolism on nicotine's pharmacological effects and behavioral responses: insights from a Cyp2a(4/5)bgs-null mouse.	CYP2A6 CYP2A13	1.94e-05	3	89	2	24045421
Pubmed	The Arkadia-ESRP2 axis suppresses tumor progression: analyses in clear-cell renal cell carcinoma.	ESRP2 ESRP1	1.94e-05	3	89	2	26522722
Pubmed	Highly homologous mouse Cyp2a4 and Cyp2a5 genes are differentially expressed in the liver and both express long non-coding antisense RNAs.	CYP2A6 CYP2A13	1.94e-05	3	89	2	32987105
Pubmed	Close linkage of the cytochrome P450IIA gene subfamily (Cyp2a) to Cyp2b and Coh on mouse chromosome 7.	CYP2A6 CYP2A13	1.94e-05	3	89	2	1973143
Pubmed	Alteration of the substrate specificity of mouse 2A P450s by the identity of residue-209: steroid-binding site and orientation.	CYP2A6 CYP2A13	1.94e-05	3	89	2	22217847
Pubmed	Mouse steroid 15 alpha-hydroxylase gene family: identification of type II P-450(15)alpha as coumarin 7-hydroxylase.	CYP2A6 CYP2A13	1.94e-05	3	89	2	2765478
Pubmed	A novel defensive mechanism against acetaminophen toxicity in the mouse lateral nasal gland: role of CYP2A5-mediated regulation of testosterone homeostasis and salivary androgen-binding protein expression.	CYP2A6 CYP2A13	1.94e-05	3	89	2	21252290
Pubmed	Mitochondrial targeting of bilirubin regulatory enzymes: An adaptive response to oxidative stress.	CYP2A6 CYP2A13	1.94e-05	3	89	2	25478736
Pubmed	Sexual dimorphism of testosterone 15 alpha-hydroxylase mRNA levels in mouse liver. cDNA cloning and regulation.	CYP2A6 CYP2A13	1.94e-05	3	89	2	2415518
Pubmed	Hypermethylation of carcinogen metabolism genes, CYP1A1, CYP2A13 and GSTM1 genes in head and neck cancer.	CYP1A1 CYP2A13	1.94e-05	3	89	2	20846153
Pubmed	AML1, AML2, and AML3, the human members of the runt domain gene-family: cDNA structure, expression, and chromosomal localization.	RUNX2 RUNX3	1.94e-05	3	89	2	7835892
Pubmed	Aryl hydrocarbon receptor nuclear translocator and upstream stimulatory factor regulate Cytochrome P450 2a5 transcription through a common E-box site.	CYP2A6 CYP2A13	1.94e-05	3	89	2	17466327
Pubmed	The ATP-dependent chromatin remodeling enzymes CHD6, CHD7, and CHD8 exhibit distinct nucleosome binding and remodeling activities.	CHD8 CHD6	1.94e-05	3	89	2	28533432
Pubmed	Differential distribution of CYP2A6 and CYP2A13 in the human respiratory tract.	CYP2A6 CYP2A13	1.94e-05	3	89	2	22890016
Pubmed	Shared and distinct roles mediated through C-terminal subdomains of acute myeloid leukemia/Runt-related transcription factor molecules in murine development.	RUNX2 RUNX3	1.94e-05	3	89	2	15713794
Pubmed	Genetic regulation of the RUNX transcription factor family has antitumor effects.	RUNX2 RUNX3	1.94e-05	3	89	2	28530640
Cytoband	1p36	EPHA2 H6PD RUNX3	1.07e-04	47	89	3	1p36
GeneFamily	ATP binding cassette subfamily B	ABCB10 ABCB11	6.65e-04	11	64	2	806
GeneFamily	RNA binding motif containing	CIRBP ESRP2 RBM3 ESRP1 RBM34	9.39e-04	213	64	5	725
GeneFamily	Fibronectin type III domain containing	IL12RB1 SDK2 EPHA2 OBSCN	2.48e-03	160	64	4	555
GeneFamily	PWWP domain containing	NSD2 BRD1	2.72e-03	22	64	2	1147
ToppCell	Parenchymal-NucSeq-Epithelial-Epi_airway_secretory-Secretory_Club\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	CYP2A6 DHRS3 DSP SYNE2 RUNX2 PALS2 ERN2	1.46e-07	198	89	7	1408e02e053ad3406229bfe8189da03be6366e81
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_chondroblast_(18)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	SDK2 DHRS3 CHAD CHADL RUNX3 ATP10A	2.35e-06	191	89	6	273c4a757292a9301de0eaeacdec91c9866be229
ToppCell	Children_(3_yrs)-Epithelial-club_cell-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	CYP2A6 DHRS3 EPHA2 SYNE2 ESRP1 ERN2	2.64e-06	195	89	6	dccc32fcf772e2504de7f663ef0a5bd8e23e92fc
ToppCell	10x_3'_v3-tissue-resident_(10x_3'_v3)-myeloid-myeloid_monocytic-leukocyte\|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	DSP EPHA2 SYNE2 RUNX2 RUNX3 FRMD4B	2.81e-06	197	89	6	d968d7d5608b175bb567ea3a315bf473ec3be459
ToppCell	LPS_IL1RA-Endothelial-Endothelial-Gen_Cap\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	TAOK2 SPTAN1 PPP1R9A SYNE2 LAMA4 SON	3.06e-06	200	89	6	dccec522ab0d7fff62ad6273b02aa9022dbbb8eb
ToppCell	TCGA-Ovary-Primary_Tumor-Ovarian_Carcinoma-Serous_Cystadenocarcinoma-5\|TCGA-Ovary / Sample_Type by Project: Shred V9	PPP1R9A OBSCN ACAD10 TRAK1 SON	2.08e-05	166	89	5	32d2eaf8a5d03881bf74d680825af2d5110b082d
ToppCell	Children_(3_yrs)-Immune-enucleated_erythrocyte-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	TAOK2 ESRP2 CYP2A6 BUD13 ERN2	2.20e-05	168	89	5	8f0c4dfad9f6fed9dcc31795abfe77758ceb46a1
ToppCell	10x5'-blood-Myeloid_Dendritic-pDC\|blood / Manually curated celltypes from each tissue	SDK2 EPHA2 LRP5 RUNX2 PCSK4	2.33e-05	170	89	5	59cb1262ff319349d42b11afbec2a9035b7b79f2
ToppCell	Club_cells-IPF_02\|World / lung cells shred on cell class, cell subclass, sample id	CYP2A6 DSP SYNE2 RUNX2 ERN2	2.75e-05	176	89	5	88c4ed0ab4a4ede8cad21385d799b723b5786cd9
ToppCell	metastatic_Brain-B_lymphocytes-GrB-secreting_B_cells\|B_lymphocytes / Location, Cell class and cell subclass	EPHA2 TMEM39B RUNX2 CROCC FRMD4B	2.83e-05	177	89	5	43e1d0d3cf8f0c02e67d91f8dd1761df23d59e07
ToppCell	PCW_10-12-Immune_Lymphocytic-Immune_Lymphocytic_NK/ILC-im_ILC3_(12)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	IL12RB1 RUNX2 MYO18B RUNX3 ATP10A	3.40e-05	184	89	5	3e9d75af578297950e469f23fb2d28393a2feef8
ToppCell	Control-Epithelial-Club\|Epithelial / Disease state, Lineage and Cell class	CYP2A6 KLHL5 CYP2A13 CHD6 RUNX2	3.49e-05	185	89	5	6814b3c94c7558443c038a227b5c8563d2cfeac4
ToppCell	3'-GW_trimst-1-SmallIntestine-Hematopoietic-T_cells-ILCP\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	IL12RB1 CHAD RUNX2 RUNX3 ATP10A	3.49e-05	185	89	5	e1fd66f4295056807aa29c0e4ce6b1a79cc8dfcf
ToppCell	droplet-Liver-Hepatocytes-18m-Endothelial\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RSAD1 MAN2A2 IFFO1 LAMA4 BUD13	3.59e-05	186	89	5	37860daeecd6d412bd3797f30496a56da667fbd1
ToppCell	droplet-Liver-Hepatocytes-18m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RSAD1 MAN2A2 IFFO1 LAMA4 BUD13	3.59e-05	186	89	5	60830822d3de3147816693404fd03392e04c2b8e
ToppCell	5'-GW_trimst-1.5-SmallIntestine-Hematopoietic-T_cells-ILCP\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	UCP2 RUNX2 MYO18B RUNX3 ATP10A	3.59e-05	186	89	5	428b4cbee3d3ab666cab2fc2d9c815318359e458
ToppCell	droplet-Liver-Hepatocytes-18m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RSAD1 MAN2A2 IFFO1 LAMA4 BUD13	3.59e-05	186	89	5	baebeffdd426ce767190ddefc857cc78e6a58d36
ToppCell	COVID-19-lung-Secretory\|lung / Disease (COVID-19 only), tissue and cell type	DHRS3 DSP PPP1R9A ESRP1 ERN2	3.87e-05	189	89	5	84d48e3ed25bebb8bb8074b3a2c5e2e88cff7f25
ToppCell	3'_v3-bone_marrow-Lymphocytic_NK-NK_CD56bright_CD16-\|bone_marrow / Manually curated celltypes from each tissue	CIRBP PPP1R9A CHD9 RUNX2 RUNX3	3.87e-05	189	89	5	6e402fb3fc31e4cb541e3cd140d7a86c1083dbf5
ToppCell	droplet-Large_Intestine-COLON_PROXIMAL\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DSP PPP1R9A SYNE2 CHD9 LARP4	4.07e-05	191	89	5	60c986d2dcbc19d9338c03da6cb5e1d92fd48f8e
ToppCell	droplet-Large_Intestine-COLON_PROXIMAL-30m-Epithelial\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DSP PPP1R9A SYNE2 CHD9 LARP4	4.07e-05	191	89	5	09db184cb90fe282a14474d7217068c58092c6f8
ToppCell	PCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_chondroblast_(18)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	SDK2 DHRS3 CHAD CHADL ATP10A	4.07e-05	191	89	5	f9a46956778a8773d6656340ecf5d218376d79c2
ToppCell	droplet-Large_Intestine-COLON_PROXIMAL-30m\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DSP PPP1R9A SYNE2 CHD9 LARP4	4.07e-05	191	89	5	973117730d6ba5f127e7a0bfabfd0ff2ca7ac131
ToppCell	368C-Endothelial_cells-Endothelial-F_(Lymphatics)\|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)	DSP PPP1R9A UCP2 ZFHX3 IGSF3	4.17e-05	192	89	5	b016e229300c183e14c0e2bba494bf49c7899112
ToppCell	368C-Endothelial_cells-Endothelial-F_(Lymphatics)-\|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)	DSP PPP1R9A UCP2 ZFHX3 IGSF3	4.17e-05	192	89	5	ac96831492c62ad9e1f7d0b764fbdf7d8a189ad9
ToppCell	5'-GW_trimst-2-SmallIntestine-Epithelial-goblet\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ESRP2 DSP ESRP1 PALS2 ERN2	4.27e-05	193	89	5	402aad2f9e789ad1f2e1536cdc9ce61de7625427
ToppCell	3'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.0.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CYP2A6 CYP2A13 CHAD GALNT7 ERN2	4.27e-05	193	89	5	605fc2a25ed6846fb283b2918cfed98df6039d6b
ToppCell	Epithelial-club_cell\|World / Lineage, Cell type, age group and donor	FNIP2 CYP2A6 PPP1R9A ESRP1 ERN2	4.27e-05	193	89	5	2bdd09004fa433550958ec42ba4b06271a4aaf7c
ToppCell	Bac-SEP-Lymphocyte-T_NK-NK\|Bac-SEP / Disease, Lineage and Cell Type	IL12RB1 DHRS3 PPP1R9A SYNE2 RUNX3	4.27e-05	193	89	5	8aa4ed2b11c6189d86e7de6bc68782fd156a37fb
ToppCell	PCW_07-8.5-Epithelial-Epithelial_proliferating-epi_proliferating1_(8)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	ESRP2 DSP PPP1R9A UCP2 ESRP1	4.27e-05	193	89	5	979980369d2dbee9dc4770d72b93037abd7786eb
ToppCell	5'-GW_trimst-2-SmallIntestine-Epithelial-goblet-Goblet_cell\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ESRP2 DSP ESRP1 PALS2 ERN2	4.27e-05	193	89	5	7ee3b1ef5c455f321b4e154ae62c69543fe9b30e
ToppCell	Control-NK_CD56bright\|Control / Disease condition and Cell class	PPP1R9A CHD9 ZFHX3 RUNX2 RUNX3	4.27e-05	193	89	5	8b1e7a226a6057e1097c1525984127b54e823876
ToppCell	Club_cells\|World / lung cells shred on cell class, cell subclass, sample id	CYP2A6 DSP SYNE2 RUNX2 ERN2	4.27e-05	193	89	5	9d3165dc5763a07a7d873f497624d9d6528fa2db
ToppCell	Goblet\|World / shred by cell class for turbinate	CYP2A6 CYP2A13 CHAD GALNT7 ERN2	4.38e-05	194	89	5	03b62e7cff5e7a6e7bd7d9dda273c74bf9c1f42e
ToppCell	nucseq-Epithelial-Epithelial_Alveolar-Secretory/RAS\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	CYP1A1 CYP2A6 EPHA2 LRP5 ERN2	4.38e-05	194	89	5	0cd4363627acd419e00d6d32f6dce10430aa6487
ToppCell	nucseq-Epithelial-Epithelial_Alveolar-Secretory/RAS-RAS\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	CYP1A1 CYP2A6 EPHA2 LRP5 ERN2	4.38e-05	194	89	5	a58841b34efe673671a9a059238e044a7254b279
ToppCell	IPF-Endothelial-Lymphatic\|Endothelial / Disease state, Lineage and Cell class	DSP PPP1R9A LAMA4 ATP10A IGSF3	4.49e-05	195	89	5	de88e9d22044b4b3e29676ad02b3e9299cc920ad
ToppCell	normal_Lung-Epithelial_cells-Club\|normal_Lung / Location, Cell class and cell subclass	CYP2A6 CYP2A13 DSP EPHA2 ERN2	4.49e-05	195	89	5	b46544ad5af04f4dbc2643637caa3d2d50d922ae
ToppCell	Neuron-Postmitotic-Excitatory_Neuron_-IPC/newborn-38\|World / Primary Cells by Cluster	CIRBP TENM4 SYNE2 CHD9 FRMD4B	4.60e-05	196	89	5	38da0751941adca650fe9b383d9f343153978eb5
ToppCell	Neuron-Postmitotic-Excitatory_Neuron_-IPC/newborn\|World / Primary Cells by Cluster	CIRBP TENM4 SYNE2 CHD9 FRMD4B	4.60e-05	196	89	5	721650a08d260faf530dbd52d4e9275d27f3bac2
ToppCell	356C-Endothelial_cells-Endothelial-F_(Lymphatics)-\|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)	DSP PPP1R9A PEPD ZFHX3 IGSF3	4.60e-05	196	89	5	b04ca69b0ed44e09c989b575f747e1e819cd8008
ToppCell	Bronchial_Biopsy-Epithelial-Club\|Bronchial_Biopsy / Tissue, Lineage and Cell class of Lung Cells from 10X	CYP2A13 PPP1R9A UCP2 GALNT7 ERN2	4.60e-05	196	89	5	057d150bdf0cad959fd03ec2d1560a96ba03fae9
ToppCell	356C-Endothelial_cells-Endothelial-F_(Lymphatics)\|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)	DSP PPP1R9A PEPD ZFHX3 IGSF3	4.60e-05	196	89	5	a31e227de2dc077b81881295b012d22fedbd65ed
ToppCell	wk_08-11-Epithelial-Airway_epithelial_progenitor-epi-airway_progenitor_early\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	ESRP2 CACNG6 DSP UCP2 ESRP1	4.71e-05	197	89	5	4ae08ccb6f1da626c4f0fb0140a2811cb6e31ba1
ToppCell	Bronchial_Biopsy-Epithelial-Club\|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X	CYP2A13 PPP1R9A UCP2 GALNT7 ERN2	4.71e-05	197	89	5	3f5dfa892a1f631b96eeb6f4cfc284aee51d1ce6
ToppCell	Parenchymal-NucSeq-Epithelial-Epi_airway_secretory\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	CYP2A6 DHRS3 DSP RUNX2 ERN2	4.83e-05	198	89	5	af399569c718f5fd971d73a7926768c9311002a3
ToppCell	CV\|World / Virus stimulation, Condition and Cluster	IL12RB1 RBM3 SPTAN1 UCP2 SYNE2	4.83e-05	198	89	5	6a28193af35abec5c029129930c2ca6febaafde2
ToppCell	CD8+_Memory_T_cell-CV\|CD8+_Memory_T_cell / cell class, Virus stimulation and cluster	IL12RB1 RBM3 SPTAN1 UCP2 SYNE2	4.83e-05	198	89	5	3d1749f5106f0912f4a74615863853949f52c73d
ToppCell	(02)_MMP9/10+-(2)_GFP_FOXI1\|(02)_MMP9/10+ / shred by cell type by condition	KLHL5 SYNE2 SMARCA2 GALNT7 PPCS	4.94e-05	199	89	5	18a7f9ced4364f45b184bd529f32ef02c27779d3
ToppCell	LPS_only-Epithelial_alveolar-AT_1-AT1\|LPS_only / Treatment groups by lineage, cell group, cell type	DHRS3 DSP EPHA2 ESRP1 ACAD10	4.94e-05	199	89	5	ccdde5d4bcc72f230a1dd2544ee7f4dfb98a5e80
ToppCell	control-Epithelial-Secretory\|control / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	DHRS3 CHD9 H6PD GALNT7 ERN2	4.94e-05	199	89	5	262e5b8a52c8ddb0b47048c786e8bdb7158e1b9a
ToppCell	LPS_IL1RA_TNF-Epithelial_alveolar\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	DHRS3 DSP EPHA2 ESRP1 ACAD10	5.06e-05	200	89	5	c89f3cb36bb14c476d6a392bfd3ded1c8feecfeb
ToppCell	Sigmoid-T_cell-Th1\|T_cell / Region, Cell class and subclass	DHRS3 CHD9 RUNX2 RUNX3 FRMD4B	5.06e-05	200	89	5	bc9433a8ec3a6f10816730a32b821c63d78e6e87
ToppCell	Tracheal-NucSeq-Epithelial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	PPP1R9A ESRP1 LRP5 GALNT7 ERN2	5.06e-05	200	89	5	d3af0a706baf66e3f32e67b17dcfc31e5b32ce0e
ToppCell	Sepsis-Bac-SEP-Lymphocyte-T/NK-NK\|Bac-SEP / Disease, condition lineage and cell class	IL12RB1 DHRS3 PPP1R9A SYNE2 RUNX3	5.06e-05	200	89	5	394ec91eb3eafde313d67abc986095799ab4e6ac
ToppCell	Tracheal-NucSeq-Epithelial-Epi_submucosal-gland\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	PPP1R9A ESRP1 LRP5 GALNT7 ERN2	5.06e-05	200	89	5	0eb9ad8c0373bcc62029ec21c590ed03aaacd039
ToppCell	COVID-19_Mild-Neu_3\|World / 5 Neutrophil clusters in COVID-19 patients	ESRP2 SDK2 OBSCN LINC02872	1.05e-04	122	89	4	2aa9cfadab70312882ae679e3788fc7ab996c0f3
ToppCell	LPS-antiTNF-Myeloid-Monocytes,_Macrophages-T-cells\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	MAN2A2 RUNX3 PCSK4 JPH3	1.60e-04	136	89	4	186be8e1595608004b8216892cb9c7a7f31fbb4d
ToppCell	Smart-seq2-tissue-resident_(Smart-seq2)-myeloid-myeloid_dendritic-plasmacytoid_dendritic_cell\|tissue-resident_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	SDK2 EPHA2 RUNX2 CROCC	1.74e-04	139	89	4	7e2c10830c3d16109cab3ed0d64b3532481e497d
ToppCell	facs-Lung-Endomucin-24m-Myeloid-Myeloid_Dendritic_Type_2\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FNIP2 PEPD RUNX2 RUNX3	1.89e-04	142	89	4	0a87c0d74e281da5dc4f59e09a5e99c62b1ea801
ToppCell	LPS-IL1RA+antiTNF-Hematopoietic_Mast-Mast_cells-T-cells\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	IL12RB1 RUNX2 RUNX3 ATP10A	2.39e-04	151	89	4	b85a763459a0f019d1f9975d09b9f2247d62c9d3
ToppCell	frontal_cortex-Neuronal-glutamatergic_neuron-L6_CT-L6_CT_ALM_Cpa6\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	SDK2 DHRS3 OBSCN ZFHX3	2.57e-04	154	89	4	12cbc38bc1f7231c67e1d2d5e86e95bc12e24682
ToppCell	frontal_cortex-Neuronal-glutamatergic_neuron-L6_CT\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	SDK2 DHRS3 OBSCN ZFHX3	2.70e-04	156	89	4	fe383ce3a0c37f7343d7026cb51260a04d4c2829
ToppCell	COVID-19_Mild-Neu_0\|COVID-19_Mild / 5 Neutrophil clusters in COVID-19 patients	UCP2 ZFHX3 TRAK1	2.73e-04	63	89	3	1ab77b6f098686bc168427159282bbf3538d4292
ToppCell	primary_visual_cortex-Neuronal-glutamatergic_neuron-L6_CT\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	SDK2 DHRS3 OBSCN ZFHX3	3.12e-04	162	89	4	58da6bc04cdac0002b0e6a751c96ff95e1a7f70f
ToppCell	primary_visual_cortex-Neuronal-glutamatergic_neuron-L6_CT-L6_CT_VISp_Ctxn3_Sla\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	SDK2 DHRS3 OBSCN ZFHX3	3.12e-04	162	89	4	4d13c271b4f63cf32980e5643b5d5951165fe8b5
ToppCell	facs-Liver-Liver_non-hepato/SCs_st-18m-Lymphocytic-CD8-positive,_alpha-beta_T_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IL12RB1 B3GNT9 RUNX2 PCSK4	3.19e-04	163	89	4	a24db9d266a40f3bffe4f18d277bc269791b4560
ToppCell	LV-11._Adipocyte\|World / Chamber and Cluster_Paper	TENM4 DHRS3 LAMA4 CHAD	3.42e-04	166	89	4	7e5852891714465c6228c9f955fd511ec79d0e02
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT2_L6_FEZF2-Exc_L6_FEZF2_SLITRK6\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	NAT1 SDK2 ZFHX3 ATP10A	3.42e-04	166	89	4	a907d39ca5cf023de633fe5f2b28759b7af4eebc
ToppCell	mild_COVID-19_(asymptomatic)-pDC\|World / disease group, cell group and cell class (v2)	TENM4 EPHA2 LRP5 RUNX2	3.50e-04	167	89	4	bf08f17965a4dd03f371b4ed0ab0d5e62ed61307
ToppCell	facs-Brain_Myeloid-Hippocampus-24m-Myeloid\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CIRBP KIF21B RBM3 ZFHX3	3.50e-04	167	89	4	7f3224af9b30082b927a822b91f96e0c88151b4e
ToppCell	facs-Brain_Myeloid-Hippocampus-24m-Myeloid-nan\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CIRBP KIF21B RBM3 ZFHX3	3.50e-04	167	89	4	a21a2b301d0a3d7a41e605f7a3c37548962a331d
ToppCell	facs-Brain_Myeloid-Hippocampus-24m\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CIRBP KIF21B RBM3 ZFHX3	3.50e-04	167	89	4	0e746483773bde6582874a33591ab2a578d724eb
ToppCell	Club_cells-IPF_03\|World / lung cells shred on cell class, cell subclass, sample id	CYP2A6 CYP2A13 DSP RUNX2	3.50e-04	167	89	4	dbdaaeb3bd9139cb008d9fe24ec031fc5628f136
ToppCell	droplet-Heart-nan-18m-Hematologic-coronary_vascular_endothelial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TAOK2 CYP1A1 EPHA2 ODAD4	3.58e-04	168	89	4	2201ae834b53cbdc085f8f02607fa5b5bd911268
ToppCell	mild_COVID-19_(asymptomatic)-pDC\|mild_COVID-19_(asymptomatic) / disease group, cell group and cell class (v2)	TENM4 EPHA2 LRP5 RUNX2	3.58e-04	168	89	4	968405ea56f7d001ef83ff9274610923c3b2d55d
ToppCell	droplet-Liver-LIVER-NPC-1m-Myeloid-plasmacytoid_dendritic_cells\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	B3GNT9 OBSCN RUNX2 RUNX3	3.58e-04	168	89	4	e8878ec68b21c8d5694d7209b816d2f869673164
ToppCell	droplet-Liver-LIVER-NPC-1m-Myeloid-plasmacytoid_dendritic_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	B3GNT9 OBSCN RUNX2 RUNX3	3.58e-04	168	89	4	a007758c219d3d5db2b5529f29af63be0d408304
ToppCell	BAL-Control-Lymphocyte-T/NK-NK_cell-NK-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	PPP1R9A SYNE2 RUNX2 RUNX3	3.66e-04	169	89	4	e9c0e0f4c421c7bdbf1a7e33002f3cf22ea307cb
ToppCell	facs-Heart-LV-18m-Mesenchymal\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TENM4 LAMA4 RUNX2 IGSF3	3.66e-04	169	89	4	849a8f8509c58d65462a09c84d58b6ecdc8934f5
ToppCell	BAL-Control-Lymphocyte-T/NK-NK_cell\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	PPP1R9A SYNE2 RUNX2 RUNX3	3.66e-04	169	89	4	d375a1df1ecc938f66bad92e54b8cda26ca9c472
ToppCell	BAL-Control-Lymphocyte-T/NK-NK_cell-NK\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	PPP1R9A SYNE2 RUNX2 RUNX3	3.66e-04	169	89	4	58f805c0be507bd5fadc9ea3555032daabbc8ab8
ToppCell	E17.5-Mesenchymal-mesenchymal_fibroblast-tracheal_fibroblast\|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	SDK2 CHAD CHADL PCSK4	3.66e-04	169	89	4	58e22f9119240664515fe91ca53812611a8f17d6
ToppCell	facs-Brain_Myeloid-Hippocampus-24m-Myeloid-microglial_cell\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CIRBP KIF21B RBM3 ZFHX3	3.74e-04	170	89	4	b4f2c05db2c2591561fd42febc72eed3b5e8f9fb
ToppCell	3'-GW_trimst-1.5-LargeIntestine-Epithelial-goblet-Goblet_cell\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ESRP1 GALNT7 ERN2 ATP10A	3.74e-04	170	89	4	2c5a1469e5743870e96e6c2cc92f0c5096b79f51
ToppCell	10x_3'_v3-spleen_(10x_3'_v3)-lymphocytic-innate_lymphocytic-innate_lymphoid_cell\|spleen_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	PPP1R9A SMARCA2 RUNX2 ATP10A	3.74e-04	170	89	4	6c65ddb496030bb479ef346cc37a9d4dfa6b824f
ToppCell	3'-GW_trimst-1.5-LargeIntestine-Epithelial-goblet\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ESRP1 GALNT7 ERN2 ATP10A	3.74e-04	170	89	4	9bea81031cdfe45e8cddac3a3afd9ca6c331c45a
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal--glomerular_mesenchymal_cell-Renin-positive_Juxtaglomerular_Granular_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SPEG ZFHX3 MYO18B ATP10A	3.74e-04	170	89	4	99dd734c0972a40d5381e8e2d96bdaa31f6d06e6
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal--glomerular_mesenchymal_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SPEG ZFHX3 MYO18B ATP10A	3.74e-04	170	89	4	3a14eeae221b8bb0bd0dadcb8e7a603431240a1e
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SPEG ZFHX3 MYO18B ATP10A	3.74e-04	170	89	4	cdb6fad277f284c3fd5a6f45672a8edc24715882
ToppCell	tumor_Lung-Endothelial_cells-EPCs\|Endothelial_cells / Location, Cell class and cell subclass	IL12RB1 UCP2 RUNX2 RUNX3	3.82e-04	171	89	4	dcb6c41980008d0b9eeb54999faff77311554976
ToppCell	TCGA-Bladder-Primary_Tumor-Urothelial_Carcinoma-Non-Papillary_Muscle_Invasive_Urothelial_Carcinoma-9\|TCGA-Bladder / Sample_Type by Project: Shred V9	B3GNT9 DHRS3 EPHA2 ABCB11	3.82e-04	171	89	4	adbcfa4bf6bc1c604535a24435924cdb091e2dd7
ToppCell	droplet-Spleen-nan-18m-Myeloid-macrophage_dendritic_cell_progenitor\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EPHA2 OBSCN ZFHX3 RUNX2	3.82e-04	171	89	4	4e856441063e9825b6f87a1d3dd19c77dae4662c
ToppCell	PND10-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-ASMC\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	PRICKLE4 SPEG LAMA4 MYO18B	3.82e-04	171	89	4	82de2885c8ce4fb7776da6a0207b3355c0910121
ToppCell	PND10-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-ASMC-ASMC_mature\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	PRICKLE4 SPEG LAMA4 MYO18B	3.82e-04	171	89	4	09e653973962fb884878089d281f0947f7a285f6
ToppCell	(07)_Ionocytes-(2)_GFP_FOXI1\|(07)_Ionocytes / shred by cell type by condition	KLHL5 DHRS3 EPHA2 GALNT7	3.91e-04	172	89	4	5776b638b845d054f6e884e7df0412477f48517d
ToppCell	droplet-Spleen-SPLEEN-30m-Myeloid-macrophage_dendritic_cell_progenitor\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EPHA2 SYNE2 ESRP1 RUNX2	3.91e-04	172	89	4	30916a902c151907745756d14327e24adc34afef
ToppCell	nucseq-Mesenchymal-Fibroblastic-Fibroblastic_2-ASMC\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	ST6GAL2 SPEG LAMA4 ZFHX3	4.00e-04	173	89	4	cb6389536195443633adb06e5f1b7483530773d1
ToppCell	facs-Trachea-nan-24m-Mesenchymal-chondrocyte\|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CIRBP CHAD CHADL RUNX2	4.00e-04	173	89	4	2226505610af1becc253d0a5550627144ef0ed6b
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT2_L6_FEZF2-Exc_L6_FEZF2_TBCC\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	KLHL5 SDK2 LAMA4 ZFHX3	4.08e-04	174	89	4	912a9e892b29d945666fc37c986009c97c668ac8
Drug	benzyl selenocyanate	CYP1A1 CYP2A6 CYP2A13	5.55e-07	5	88	3	ctd:C054108
Drug	N-methyl-N-2-(methylsulfinyl)ethylpropionic acid amide	CYP1A1 CYP2A6 CYP2A13	5.55e-07	5	88	3	ctd:C062567
Drug	1-ethynylpyrene	CYP1A1 CYP2A6 PDCD6 DSP	6.12e-07	18	88	4	CID000154905
Drug	Lymecycline [992-21-2]; Down 200; 6.6uM; PC3; HT_HG-U133A	HABP4 DHRS3 PPP1R9A UCP2 ATG2B SMARCA2 BRD1 LARP4	1.09e-06	200	88	8	7291_DN
Drug	N'-nitrosoanabasine	CYP1A1 CYP2A6 CYP2A13	1.11e-06	6	88	3	ctd:C010257
Drug	phenacetin	CYP1A1 CYP2A6 CYP2A13 PDCD6 PEPD	2.30e-06	55	88	5	CID000004754
Drug	N-nitrosoguvacoline	CYP1A1 CYP2A6 CYP2A13	4.61e-06	9	88	3	CID000062103
Drug	3-(methylnitrosamino)propionaldehyde	CYP1A1 CYP2A6 CYP2A13	4.61e-06	9	88	3	CID000098533
Drug	acenaphthylene	CYP1A1 CYP2A6 CYP2A13	4.61e-06	9	88	3	ctd:C042553
Drug	1-aminobenzotriazole	CYP1A1 CYP2A6 CYP2A13 ABCB11 H6PD	8.19e-06	71	88	5	CID000001367
Drug	debrisoquine	CYP1A1 NAT1 CYP2A6 CYP2A13 PEPD	1.07e-05	75	88	5	CID000002965
Drug	estradiol, USP; Down 200; 0.01uM; MCF7; HT_HG-U133A	CYP1A1 HABP4 TTLL5 PPP1R9A ACAD10 ERN2 TRAK1	1.15e-05	197	88	7	5238_DN
Drug	Sulfasalazine [599-79-1]; Down 200; 10uM; PC3; HT_HG-U133A	HABP4 MAN2A2 SPTAN1 TTLL5 ZFHX3 ACAD10 ERN2	1.18e-05	198	88	7	6346_DN
Drug	Cloperastine hydrochloride [14984-68-0]; Up 200; 11uM; HL60; HT_HG-U133A	TAOK2 ESRP2 CYP1A1 LAMA4 ABCB11 ZFHX3 RBM34	1.18e-05	198	88	7	2549_UP
Drug	x Me	CYP1A1 NAT1 CYP2A6 PDCD6	1.39e-05	38	88	4	CID009600424
Drug	propargyl ether	CYP2A6 CYP2A13	1.48e-05	2	88	2	ctd:C531209
Drug	Hempa	CYP2A6 CYP2A13	1.48e-05	2	88	2	ctd:D006492
Drug	nicotine imine	CYP2A6 CYP2A13	1.48e-05	2	88	2	ctd:C034629
Drug	alpha-nicotyrine	CYP2A6 CYP2A13	1.48e-05	2	88	2	ctd:C008615
Drug	N-nitrosoguvacoline	CYP2A6 CYP2A13	1.48e-05	2	88	2	ctd:C036676
Drug	d 6-20	CYP1A1 CYP2A6 CYP2A13	1.55e-05	13	88	3	CID000161569
Drug	Skatole	CYP1A1 CYP2A6 CYP2A13	1.55e-05	13	88	3	ctd:D012862
Drug	MnPN	CYP1A1 CYP2A6 CYP2A13	1.97e-05	14	88	3	CID000062163
Drug	N'-nitrosonornicotine	CYP1A1 CYP2A6 CYP2A13	2.45e-05	15	88	3	ctd:C008655
Drug	polybrominated biphenyl	CYP1A1 CYP2A6 CYP2A13 PDCD6	2.51e-05	44	88	4	CID000042948
Drug	2-aminoanthracene	CYP1A1 NAT1 CYP2A6 PDCD6	2.75e-05	45	88	4	CID000011937
Drug	p-nitroanisole	CYP1A1 CYP2A6 CYP2A13 PDCD6 H6PD	2.90e-05	92	88	5	CID000007485
Drug	NSC210759	CYP1A1 CYP2A6 PDCD6	3.01e-05	16	88	3	CID000308728
Drug	nitro-L	CYP1A1 CYP2A6 CYP2A13 PDCD6	3.56e-05	48	88	4	CID000006849
Drug	o-xylene	CYP1A1 CYP2A6 PDCD6 RUNX3	3.56e-05	48	88	4	CID000007237
Drug	Methoxsalen	CYP1A1 CYP2A6 CYP2A13 ABCB11	3.56e-05	48	88	4	ctd:D008730
Drug	acepyrene	CYP1A1 CYP2A6 PDCD6	3.65e-05	17	88	3	CID000033743
Drug	S)-cotinine	CYP1A1 CYP2A6 CYP2A13 PDCD6 PEPD	3.75e-05	97	88	5	CID000000408
Drug	Isradipine	CYP1A1 CYP2A6 ABCB11	4.37e-05	18	88	3	ctd:D017275
Drug	D 703	CYP1A1 CYP2A6 CYP2A13	4.37e-05	18	88	3	CID000054088
Drug	AC1L22BR	CYP1A1 PDCD6	4.42e-05	3	88	2	CID000039728
Drug	1,3,6,7,8-pentachlorodibenzofuran	CYP1A1 PDCD6	4.42e-05	3	88	2	CID000051126
Drug	2,2',4,4',5,6'-hexaCDE	CYP1A1 PDCD6	4.42e-05	3	88	2	CID000041556
Drug	2,4,6,8-tetrachlorodibenzofuran	CYP1A1 PDCD6	4.42e-05	3	88	2	CID000042843
Drug	AC1L3G5Z	CYP1A1 PDCD6	4.42e-05	3	88	2	CID000114896
Drug	n-propyl disulfide	CYP1A1 CYP2A6	4.42e-05	3	88	2	ctd:C041288
Drug	2'-methoxyacetophenone	CYP2A6 CYP2A13	4.42e-05	3	88	2	CID000068481
Drug	dipropyl sulfide	CYP1A1 CYP2A6	4.42e-05	3	88	2	ctd:C087894
Drug	Sparteinum	CYP1A1 NAT1 CYP2A6 CYP2A13 PEPD	4.55e-05	101	88	5	CID000003966
Drug	NDMA	CYP1A1 NAT1 CYP2A6 PDCD6	4.90e-05	52	88	4	CID000008749
Drug	6-aminochrysene	CYP1A1 CYP2A6 PDCD6	5.17e-05	19	88	3	CID000017534
Drug	D 617	CYP1A1 CYP2A6 CYP2A13	5.17e-05	19	88	3	CID000093168
Drug	9-hydroxybenzo(a)pyrene	CYP1A1 CYP2A6 CYP2A13 PDCD6	5.28e-05	53	88	4	CID000028598
Drug	paraxanthine	CYP1A1 NAT1 CYP2A6 CYP2A13	5.28e-05	53	88	4	CID000004687
Drug	Cotinine	CYP1A1 NAT1 CYP2A6	6.06e-05	20	88	3	ctd:D003367
Drug	acetanilide	CYP1A1 NAT1 CYP2A6 PDCD6	6.56e-05	56	88	4	CID000000904
Drug	MBOCA	CYP1A1 NAT1 CYP2A6	8.15e-05	22	88	3	CID000007543
Drug	monoazo	CYP1A1 PDCD6 ABCB11	8.15e-05	22	88	3	CID000011490
Drug	HpCDF	CYP1A1 PDCD6	8.82e-05	4	88	2	CID000038199
Drug	5-hydroxycoumarin	CYP1A1 CYP2A6	8.82e-05	4	88	2	CID005318179
Drug	bromopentachlorobenzene	CYP1A1 PDCD6	8.82e-05	4	88	2	CID003014710
Drug	N'-nitrosoanatabine	CYP2A6 CYP2A13	8.82e-05	4	88	2	ctd:C032978
Drug	7-ethoxy-4-methylcoumarin	CYP1A1 CYP2A6	8.82e-05	4	88	2	CID000066595
Drug	tetrachlorodibenzofuran	CYP1A1 PDCD6	8.82e-05	4	88	2	CID000035331
Drug	NMPA	CYP2A6 CYP2A13	8.82e-05	4	88	2	CID000132101
Drug	1,3,6,8-tetrachlorodibenzo-p-dioxin	CYP1A1 PDCD6	8.82e-05	4	88	2	CID000036474
Drug	3-methyleneindolenine	CYP1A1 CYP2A13	8.82e-05	4	88	2	ctd:C097745
Drug	picene	CYP1A1 PDCD6	8.82e-05	4	88	2	CID000009162
Drug	BP-4,5-oxide	CYP1A1 CYP2A6 CYP2A13 PDCD6	9.19e-05	61	88	4	CID000037786
Drug	alpha-naphthoflavone	CYP1A1 CYP2A6 CYP2A13 PDCD6 DDX4	9.55e-05	118	88	5	CID000011790
Drug	chlorzoxazone	CYP1A1 CYP2A6 CYP2A13 PDCD6	1.04e-04	63	88	4	CID000002733
Drug	N-nitrosomethylethylamine	CYP1A1 CYP2A6 PDCD6	1.06e-04	24	88	3	CID000025418
Drug	omeprazole sulfone	CYP1A1 CYP2A6 LRP5	1.06e-04	24	88	3	CID000145900
Drug	GSK-3 Inhibitor IX; Up 200; 0.5uM; PC3; HT_HG-U133A	TAOK2 CYP1A1 HABP4 H6PD ERN2 ATP10A	1.11e-04	195	88	6	7106_UP
Drug	GSK-3 Inhibitor IX; Up 200; 0.5uM; PC3; HT_HG-U133A	CYP1A1 MAN2A2 UCP2 ACAD10 RUNX3 ERN2	1.11e-04	195	88	6	7048_UP
Drug	SC-560; Up 200; 10uM; PC3; HT_HG-U133A	TAOK2 SMARCA2 LAMA4 ACAD10 PALS2 ATP10A	1.14e-04	196	88	6	6865_UP
Drug	DNA-PK Inhibitor III; Down 200; 1uM; MCF7; HT_HG-U133A	CYP1A1 SPTAN1 TTLL5 ACAD10 ERN2 RBM34	1.17e-04	197	88	6	7543_DN
Drug	Minoxidil [38304-91-5]; Down 200; 19.2uM; PC3; HT_HG-U133A	SPTAN1 TTLL5 SMARCA2 RUNX3 ERN2 TRAK1	1.17e-04	197	88	6	4216_DN
Drug	Piribedil hydrochloride [78213-63-5]; Up 200; 12uM; MCF7; HT_HG-U133A	TAOK2 KIF21B IL12RB1 MAN2A2 DHRS3 EPHA2	1.20e-04	198	88	6	5434_UP
Drug	1,4-phenylenebis(methylene)selenocyanate	CYP1A1 CYP2A6 CYP2A13	1.21e-04	25	88	3	ctd:C074153
Drug	methylpropylnitrosamine	CYP1A1 CYP2A6 PDCD6	1.21e-04	25	88	3	CID000013545
Drug	Trichostatin A, from Streptomyces sp.; Down 200; 0.1uM; PC3; HT_HG-U133A	MAN2A2 NSD2 SPEG UCP2 SMARCA2 TRAK1	1.24e-04	199	88	6	4526_DN
Drug	Alprenolol hydrochloride [13707-88-5]; Up 200; 14uM; PC3; HT_HG-U133A	TAOK2 TTLL5 SMARCA2 ZFHX3 ERN2 IGSF3	1.24e-04	199	88	6	7141_UP
Drug	Enilconazole [35554-44-0]; Up 200; 13.4uM; MCF7; HT_HG-U133A	TAOK2 MAN2A2 DHRS3 LAMA4 H6PD JPH3	1.27e-04	200	88	6	6518_UP
Drug	Felodipine	CYP1A1 CYP2A6 ABCB11	1.36e-04	26	88	3	ctd:D015736
Drug	DEET	CYP1A1 CYP2A6 CYP2A13 UCP2 PEPD ABCB11	1.41e-04	204	88	6	ctd:D003671
Drug	AC1L1AY1	CYP1A1 PDCD6	1.47e-04	5	88	2	CID000051374
Drug	PCB 138	CYP1A1 PDCD6	1.47e-04	5	88	2	CID000037035
Drug	2,2',4,4',5,5'-hexaCDE	CYP1A1 PDCD6	1.47e-04	5	88	2	CID000051439
Drug	aflatoxin B1-DNA adduct	CYP1A1 CYP2A13	1.47e-04	5	88	2	ctd:C072611
Drug	diphenyl	CYP1A1 CYP2A13	1.47e-04	5	88	2	ctd:C010574
Drug	cadmium fluoride	CYP1A1 PDCD6	1.47e-04	5	88	2	CID000024634
Drug	1,2,4-trihydroxy-9,10-anthracenedione	CYP1A1 CYP2A6	1.47e-04	5	88	2	ctd:C410870
Drug	methoxyresorufin	CYP1A1 CYP2A6 CYP2A13 PDCD6	1.49e-04	69	88	4	CID000119220
Drug	BP-9,10-oxide	CYP1A1 CYP2A6 CYP2A13	1.53e-04	27	88	3	CID000037456
Drug	Brn 4136738	CYP1A1 CYP2A6 CYP2A13	1.53e-04	27	88	3	CID000050331
Drug	7-ethoxy-4-trifluoromethylcoumarin	CYP1A1 CYP2A6 PDCD6	1.53e-04	27	88	3	CID000130779
Drug	C14845	CYP1A1 CYP2A6 CYP2A13	1.53e-04	27	88	3	CID011954064
Drug	gallocatechol	CYP1A1 ABCB11 RUNX2	1.53e-04	27	88	3	ctd:C057580
Drug	1h1q	CYP1A1 CYP2A6 CYP2A13 PDCD6	1.57e-04	70	88	4	CID000001540
Drug	9-OH-BaP-4,5-oxide	CYP1A1 CYP2A6 CYP2A13	1.70e-04	28	88	3	CID000115064
Drug	carteolol	CYP1A1 CYP2A6 CYP2A13 PDCD6	1.75e-04	72	88	4	CID000002583
Drug	6-Me-Glu-P-2	CYP1A1 NAT1 CYP2A6	1.90e-04	29	88	3	CID000049971
Drug	7-hydroxycoumarin	CYP1A1 CYP2A6 CYP2A13 PEPD	2.05e-04	75	88	4	CID005281426
Drug	19-hydroxytestosterone	CYP1A1 CYP2A6 CYP2A13	2.10e-04	30	88	3	CID000150968
Disease	CHARGE syndrome (implicated_via_orthology)	CHD9 CHD8 CHD6	8.89e-07	7	88	3	DOID:0050834 (implicated_via_orthology)
Disease	X-21286 measurement	CYP1A1 CYP2A6	5.26e-05	4	88	2	EFO_0800804
Disease	congenital heart disease (implicated_via_orthology)	CHD9 CHD8 CHD6 SON	5.51e-05	69	88	4	DOID:1682 (implicated_via_orthology)
Disease	lung non-small cell carcinoma (is_implicated_in)	NAT1 NSD2 ZFHX3 RUNX2 RUNX3	6.18e-05	139	88	5	DOID:3908 (is_implicated_in)
Disease	diacylglycerol 44:6 measurement	SYNE2 BUD13	8.74e-05	5	88	2	EFO_0020070
Disease	diastolic blood pressure, unipolar depression	NAT1 ACAD10 TRAK1	9.82e-05	30	88	3	EFO_0003761, EFO_0006336
Disease	carbohydrate intake measurement	CYP1A1 ZFHX3 ACAD10	1.43e-04	34	88	3	EFO_0010811
Disease	polycystic liver disease (implicated_via_orthology)	UCP2 LRP5	1.83e-04	7	88	2	DOID:0050770 (implicated_via_orthology)
Disease	able to hear with hearing aids	CYP1A1 PDCD6	1.83e-04	7	88	2	EFO_0009720
Disease	attention deficit hyperactivity disorder, unipolar depression, bipolar disorder, autism spectrum disorder, schizophrenia	KIF21B TENM4 SMARCA2 PALS2	2.42e-04	101	88	4	EFO_0003756, EFO_0003761, EFO_0003888, MONDO_0004985, MONDO_0005090
Disease	5-acetylamino-6-amino-3-methyluracil measurement	CYP1A1 NAT1	4.75e-04	11	88	2	EFO_0800951
Disease	hair colour measurement	TENM4 SYNE2 TCF25 LRP5 RUNX2 PALS2 ATP10A JPH3	5.06e-04	615	88	8	EFO_0007822
Disease	paraxanthine measurement	CYP1A1 CYP2A6	5.69e-04	12	88	2	EFO_0021178
Disease	aspartate aminotransferase to alanine aminotransferase ratio	JARID2 IL12RB1 EPHA2 PEPD ABCB11	7.58e-04	239	88	5	EFO_0010934
Disease	resting heart rate	HABP4 DSP SPEG FRMD4B	1.05e-03	149	88	4	EFO_0004351
Disease	autism spectrum disorder (implicated_via_orthology)	TAOK2 CHD9 CHD8 CHD6	1.13e-03	152	88	4	DOID:0060041 (implicated_via_orthology)
Disease	sphingomyelin 14:0 measurement	SYNE2 ZFHX3	1.16e-03	17	88	2	EFO_0010390
Disease	Paroxysmal atrial fibrillation	SYNE2 ZFHX3 MYO18B FRMD4B	1.24e-03	156	88	4	C0235480
Disease	familial atrial fibrillation	SYNE2 ZFHX3 MYO18B FRMD4B	1.24e-03	156	88	4	C3468561
Disease	Persistent atrial fibrillation	SYNE2 ZFHX3 MYO18B FRMD4B	1.24e-03	156	88	4	C2585653
Disease	Atrial Fibrillation	SYNE2 ZFHX3 MYO18B FRMD4B	1.36e-03	160	88	4	C0004238
Disease	caffeine metabolite measurement	CYP1A1 CYP2A6	1.45e-03	19	88	2	EFO_0007872
Disease	polymyositis	SDK2 LRP5	1.61e-03	20	88	2	EFO_0003063
Disease	Osteoarthritis of hip	CHADL RUNX2	1.61e-03	20	88	2	C0029410
Disease	left atrial function	DSP MYO18B	1.78e-03	21	88	2	EFO_0004294
Disease	Autism Spectrum Disorders	CIRBP JARID2 CHD8	2.12e-03	85	88	3	C1510586
Disease	Neoplasm of the genitourinary tract	PRCC ZFHX3	2.33e-03	24	88	2	cv:C0042065

Protein segments in the cluster

Peptide	Gene	Start	Entry
VALVRRLQSGQFGDV	BOP1	201	Q14137
GLEAIFDQVVRRNRG	NAT1	51	P18440
GVDRSNGFEQKRFAR	BUD13	586	Q9BRD0
AAVRLRDQGGVVLRQ	BRD1	651	O95696
QAFQDGLRRRALGAV	C1orf167	1046	Q5SNV9
GRVRGNLRQAAIDRF	CHD8	1181	Q9HCK8
QREREQALGDFRFGK	DDX4	576	Q9NQI0
VVFSNGERAKQLRRF	CYP2A6	116	P11509
RVIDRAIQAFGAAGL	ACAD10	1006	Q6JQN1
ERIGNVRTVRAFGKE	ABCB10	356	Q9NRK6
GGQKQRVAIARALIR	ABCB11	561	O95342
NIRTVAGIGKERRFI	ABCB11	946	O95342
QIREVAAGAFRGLKQ	CHAD	86	O15335
FFLQEENRRRGAAGR	CACNG6	6	Q9BXT2
RKDGRIVRGFQRGAA	ATG2B	1916	Q96BY7
DGETNLKRRQVVRGF	ATP10A	201	O60312
AQGRRNGEALVRFVS	ESRP1	261	Q6NXG1
KRNGAQIADGFRIRV	RBM34	261	P42696
VVVKDRETQRSRGFG	RBM3	36	P98179
NREVLQRFRGFGGVR	PEPD	436	P12955
TIRQALVRQGDDFKG	CYP1A1	91	P04798
IQIDNFRRKSDLGVG	LINC02872	71	A2RU37
FRGQFEGRAVAVKRL	ERN2	536	Q76MJ5
RANLDGSFRQKVVEG	LRP5	221	O75197
GNRVFDAFDQRGKRE	HABP4	201	Q5JVS0
NREVERLARKFGFVN	PCSK4	46	Q6UW60
RKFDRQGRGQIAFDD	PDCD6	136	O75340
FGGIAERKRRAQEQG	KIF21B	121	O75037
VRGIGRVFKNALQEA	NSD2	951	O96028
NGRRLQFGVAVLDDK	KLHL5	501	Q96PQ7
RQRSLFVVVGDRGKD	NAT10	21	Q9H0A0
RRGLGRRDQAVQTGF	IFFO1	116	Q0D2I5
QKAVIFRNVRDIGRF	OBSCN	5736	Q5VST9
FAARLGAQGRRVVLV	PPCS	26	Q9HAB8
RRKQEALGQGVARLV	PRICKLE4	61	Q2TBC4
AQGVGRRSLKNRFIV	PALS2	346	Q9NZW5
QVRRRVGTAFKLDDN	FRMD4B	476	Q9Y2L6
RRGRRKNVEGVDIFF	CHD9	2431	Q3L8U1
RVEVQRRAAEAQLGG	CROCC	1421	Q5TZA2
GRQAAFREGLEQAVR	HYI	81	Q5T013
QRVRGGKIFIERVQG	IGSF3	86	O75054
VAFSNGERAKQLRRF	CYP2A13	116	Q16696
GRVRGNLRQAAIDRF	CHD6	831	Q8TD26
NGLVKVFRNERREGL	GALNT7	266	Q86SF2
DRRGRQVLFDSKAVQ	FNIP2	56	Q9P278
LAGVGFFIHRRRKNQ	EPHA2	551	P29317
IRKGFIDGRAAQRLQ	DSP	2751	P15924
LGRVKAFAEQLGRRA	LDHD	441	Q86WU2
RGAAGKIREQRRQFS	LARP4	686	Q71RC2
VRFSVEQLGQDGRRR	IL12RB1	241	P42701
RAAVRRLVGNGQLEI	MAN2A2	231	P49641
GQRVFVVKRQNRGRE	LAMTOR4	81	Q0VGL1
NARGQRVKAAAAVFE	CHADL	706	Q6NUI6
VFQALRGLQRGSAVV	H6PD	296	O95479
VEKLTRFRQRNDGGL	SDK2	351	Q58EX2
GRQLAREFAERGARK	DHRS3	51	O75911
RDITRRGKFGQVTRF	LAMA4	1061	Q16363
RGKFGQVTRFDIEVR	LAMA4	1066	Q16363
EVGQAQLKTGRRRLF	JARID2	776	Q92833
KNQVARFNDLRFVGR	RUNX2	176	Q13950
QVARFNDLRFVGRSG	RUNX3	131	Q13761
ERGTALFAQVQRGAL	RSAD1	231	Q9HA92
EKIFGRGSRQRRDVD	SMARCA2	1301	P51531
RNRGREEINFVEIKG	PRCC	401	Q92733
QGVRQRKGDVDGLVR	SYNE2	5686	Q8WXH0
RALDNIGRVFARVGK	ODAD4	361	Q96NG3
IGRVFARVGKFQQAI	ODAD4	366	Q96NG3
SQRELGGQVDLFKRR	RNF215	281	Q9Y6U7
VRFRGKREAGLSRAQ	ST6GAL2	236	Q96JF0
QRAGFGAEAEKLARR	TAOK2	531	Q9UL54
QDVARFFKGLNVARG	ESRP2	271	Q9H6T0
AEGRVQGALVRRVFL	B3GNT9	141	Q6UX72
VVVKDRETQRSRGFG	CIRBP	36	Q14011
KVRRFGVAKVVNSGR	TRAK1	846	Q9UPV9
GDLEQVGRFIRTRKV	PPP1R27	41	Q86WC6
VARFREQLRRQEGGA	TNIP2	71	Q8NFZ5
KVRFQAQARAGGGRR	UCP2	141	P55851
IEQRVKSFNVGRGRG	ZC3H6	206	P61129
GSVAERRRLFQQKAA	SPEG	461	Q15772
QRQGKLFGAAEVQRF	SPTAN1	246	Q13813
RKEQARGQVTVFGRR	TENM4	1816	Q6N022
SEFVEGLRRKRAQRG	MYO18B	2251	Q8IUG5
QGAEARVFRGRFQGR	TP53RK	41	Q96S44
RVFRGRFQGRAAVIK	TP53RK	46	Q96S44
LFRFRNRHAIGNRKG	TIGD7	126	Q6NT04
AGKEGVRVNNRFELI	TCF25	51	Q9BQ70
LVAVGERAQKRSGNF	SON	2346	P18583
KAVNRLFGVEASGRR	TGM6	456	O95932
RVKEENDRRGGFIRI	TTLL5	471	Q6EMB2
RRFIGSIVKEASQRG	TMEM39B	136	Q9GZU3
NTRARERKGQFRAVG	ZFHX3	2691	Q15911
EDRGFGVQRLRSKAQ	JPH3	646	Q8WXH2
VLRNTKGNVRFVIGR	PPP1R9A	576	Q9ULJ8