Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyCellularComponent	host cell part	GBP7 GBP4	3.99e-04	6	109	2	GO:0033643
GeneOntologyCellularComponent	host intracellular part	GBP7 GBP4	3.99e-04	6	109	2	GO:0033646
GeneOntologyCellularComponent	host cell cytoplasm part	GBP7 GBP4	3.99e-04	6	109	2	GO:0033655
GeneOntologyCellularComponent	symbiont-containing vacuole	GBP7 GBP4	3.99e-04	6	109	2	GO:0020003
GeneOntologyCellularComponent	symbiont-containing vacuole membrane	GBP7 GBP4	3.99e-04	6	109	2	GO:0020005
GeneOntologyCellularComponent	host intracellular region	GBP7 GBP4	3.99e-04	6	109	2	GO:0043656
GeneOntologyCellularComponent	host cell cytoplasm	GBP7 GBP4	3.99e-04	6	109	2	GO:0030430
GeneOntologyCellularComponent	endoplasmic reticulum tubular network	REEP1 REEP2 REEP4	5.57e-04	31	109	3	GO:0071782
HumanPheno	Abnormal hair pattern	PPP1R21 FAT4 ZNF407 NSUN2 DHX30 JARID2 BMP1 NF1 HS2ST1 SCAPER DOCK7 TRAPPC10 PRKCZ HERC2 VPS13B GABRA3	1.50e-05	676	39	16	HP:0010720
Domain	ZINC_FINGER_C2H2_2	ZNF354A ZNF266 ZNF268 PATZ1 ZNF429 ZNF407 ZNF626 ZNF891 ZNF800 SALL1 ZNF253 ZNF558 SCAPER ZNF727 ZNF470 ZNF528 ZNF30 ZNF90 ZC3H7B ZNF541	1.43e-08	775	107	20	PS50157
Domain	ZINC_FINGER_C2H2_1	ZNF354A ZNF266 ZNF268 PATZ1 ZNF429 ZNF407 ZNF626 ZNF891 ZNF800 SALL1 ZNF253 ZNF558 SCAPER ZNF727 ZNF470 ZNF528 ZNF30 ZNF90 ZC3H7B ZNF541	1.49e-08	777	107	20	PS00028
Domain	Znf_C2H2-like	ZNF354A ZNF266 ZNF268 PATZ1 ZNF429 ZNF407 ZNF626 ZNF891 ZNF800 SALL1 ZNF253 ZNF558 SCAPER ZNF727 ZNF470 ZNF528 ZNF30 ZNF90 ZC3H7B ZNF541	2.22e-08	796	107	20	IPR015880
Domain	Znf_C2H2	ZNF354A ZNF266 ZNF268 PATZ1 ZNF429 ZNF407 ZNF626 ZNF891 ZNF800 SALL1 ZNF253 ZNF558 SCAPER ZNF727 ZNF470 ZNF528 ZNF30 ZNF90 ZC3H7B ZNF541	2.68e-08	805	107	20	IPR007087
Domain	ZnF_C2H2	ZNF354A ZNF266 ZNF268 PATZ1 ZNF429 ZNF407 ZNF626 ZNF891 ZNF800 SALL1 ZNF253 ZNF558 SCAPER ZNF727 ZNF470 ZNF528 ZNF30 ZNF90 ZC3H7B ZNF541	2.85e-08	808	107	20	SM00355
Domain	-	ZNF354A ZNF266 ZNF268 PATZ1 ZNF429 ZNF407 ZNF626 ZNF891 ZNF800 SALL1 ZNF253 ZNF558 ZNF727 ZNF470 ZNF528 ZNF30 ZNF90 ZNF541	5.54e-08	679	107	18	3.30.160.60
Domain	Znf_C2H2/integrase_DNA-bd	ZNF354A ZNF266 ZNF268 PATZ1 ZNF429 ZNF407 ZNF626 ZNF891 ZNF800 SALL1 ZNF253 ZNF558 ZNF727 ZNF470 ZNF528 ZNF30 ZNF90 ZNF541	7.69e-08	694	107	18	IPR013087
Domain	KRAB	ZNF354A ZNF266 ZNF268 ZNF429 ZNF626 ZNF891 ZNF253 ZNF558 ZNF727 ZNF470 ZNF528 ZNF30 ZNF90	1.36e-07	358	107	13	PS50805
Domain	KRAB	ZNF354A ZNF266 ZNF268 ZNF429 ZNF626 ZNF891 ZNF253 ZNF558 ZNF727 ZNF470 ZNF528 ZNF30 ZNF90	1.92e-07	369	107	13	SM00349
Domain	KRAB	ZNF354A ZNF266 ZNF268 ZNF429 ZNF626 ZNF891 ZNF253 ZNF558 ZNF727 ZNF470 ZNF528 ZNF30 ZNF90	1.98e-07	370	107	13	IPR001909
Domain	zf-C2H2_6	ZNF354A ZNF266 PATZ1 ZNF429 ZNF626 ZNF891 ZNF253 ZNF558 ZNF727 ZNF30 ZNF90 ZNF541	2.46e-07	314	107	12	PF13912
Domain	zf-C2H2	ZNF354A ZNF266 ZNF268 PATZ1 ZNF429 ZNF407 ZNF626 ZNF891 SALL1 ZNF253 ZNF558 ZNF727 ZNF470 ZNF528 ZNF30 ZNF90 ZNF541	4.04e-07	693	107	17	PF00096
Domain	KRAB	ZNF354A ZNF268 ZNF429 ZNF626 ZNF891 ZNF253 ZNF558 ZNF727 ZNF470 ZNF528 ZNF30 ZNF90	9.90e-07	358	107	12	PF01352
Domain	TB2_DP1_HVA22	REEP1 REEP2 REEP4	3.61e-06	6	107	3	IPR004345
Domain	TB2_DP1_HVA22	REEP1 REEP2 REEP4	3.61e-06	6	107	3	PF03134
Domain	DOCK_C	DOCK9 DOCK5 DOCK7	2.92e-05	11	107	3	IPR010703
Domain	DHR-1_domain	DOCK9 DOCK5 DOCK7	2.92e-05	11	107	3	IPR027007
Domain	DHR_2	DOCK9 DOCK5 DOCK7	2.92e-05	11	107	3	PS51651
Domain	DHR_1	DOCK9 DOCK5 DOCK7	2.92e-05	11	107	3	PS51650
Domain	DOCK-C2	DOCK9 DOCK5 DOCK7	2.92e-05	11	107	3	PF14429
Domain	DHR-2	DOCK9 DOCK5 DOCK7	2.92e-05	11	107	3	IPR027357
Domain	DHR-2	DOCK9 DOCK5 DOCK7	2.92e-05	11	107	3	PF06920
Domain	DOCK	DOCK9 DOCK5 DOCK7	2.92e-05	11	107	3	IPR026791
Domain	BMP_1/tolloid-like	BMP1 TLL2	9.72e-05	3	107	2	IPR015446
Domain	ARM-type_fold	INTS7 DOCK9 APOB DOCK5 NF1 TERB1 TTI1 WDFY3 LRBA	1.45e-04	339	107	9	IPR016024
Domain	WD40_repeat	DMXL2 CFAP251 HIRA WDR3 WDFY3 LRBA HERC2 WDSUB1	1.71e-04	272	107	8	IPR001680
Domain	WD_REPEATS_1	DMXL2 CFAP251 HIRA WDR3 WDFY3 LRBA HERC2 WDSUB1	1.99e-04	278	107	8	PS00678
Domain	WD_REPEATS_2	DMXL2 CFAP251 HIRA WDR3 WDFY3 LRBA HERC2 WDSUB1	2.04e-04	279	107	8	PS50082
Domain	WD_REPEATS_REGION	DMXL2 CFAP251 HIRA WDR3 WDFY3 LRBA HERC2 WDSUB1	2.04e-04	279	107	8	PS50294
Domain	-	FAT4 APCS FAT2 WDFY3 LRBA	2.16e-04	95	107	5	2.60.120.200
Domain	ConA-like_dom	FAT4 ZAN APCS TRIM64B FAT2 WDFY3 LRBA	2.68e-04	219	107	7	IPR013320
Domain	DUF4704	WDFY3 LRBA	3.22e-04	5	107	2	IPR031570
Domain	DUF4704	WDFY3 LRBA	3.22e-04	5	107	2	PF15787
Domain	DUF3398	DOCK9 DOCK7	4.80e-04	6	107	2	PF11878
Domain	Peptidase_M12A	BMP1 TLL2	4.80e-04	6	107	2	IPR001506
Domain	Astacin	BMP1 TLL2	4.80e-04	6	107	2	PF01400
Domain	PH_BEACH	WDFY3 LRBA	4.80e-04	6	107	2	PF14844
Domain	DOCK_C/D_N	DOCK9 DOCK7	4.80e-04	6	107	2	IPR021816
Domain	GABAAa_rcpt	GABRA1 GABRA3	4.80e-04	6	107	2	IPR001390
Domain	EGF_CA	FAT4 LRP1B BMP1 FAT2 TLL2	6.85e-04	122	107	5	SM00179
Domain	WD40	DMXL2 CFAP251 HIRA WDR3 WDFY3 LRBA WDSUB1	7.30e-04	259	107	7	PF00400
Domain	EGF-like_Ca-bd_dom	FAT4 LRP1B BMP1 FAT2 TLL2	7.37e-04	124	107	5	IPR001881
Domain	EGF	ZAN LRP1B BMP1 FAT2 TLL2	7.92e-04	126	107	5	PF00008
Domain	PH-BEACH_dom	WDFY3 LRBA	8.90e-04	8	107	2	IPR023362
Domain	-	WDFY3 LRBA	8.90e-04	8	107	2	2.30.29.40
Domain	PH_BEACH	WDFY3 LRBA	8.90e-04	8	107	2	PS51783
Domain	WD40	DMXL2 CFAP251 HIRA WDR3 WDFY3 LRBA WDSUB1	8.91e-04	268	107	7	SM00320
Domain	BEACH_dom	WDFY3 LRBA	1.14e-03	9	107	2	IPR000409
Domain	BEACH	WDFY3 LRBA	1.14e-03	9	107	2	PS50197
Domain	Beach	WDFY3 LRBA	1.14e-03	9	107	2	PF02138
Domain	-	WDFY3 LRBA	1.14e-03	9	107	2	1.10.1540.10
Domain	zf-C2H2_11	ZNF354A ZNF800	1.14e-03	9	107	2	PF16622
Domain	Beach	WDFY3 LRBA	1.14e-03	9	107	2	SM01026
Domain	GBP_C	GBP7 GBP4	1.42e-03	10	107	2	PF02841
Domain	EGF_CA	FAT4 LRP1B BMP1 TLL2	1.51e-03	86	107	4	PF07645
Domain	WD40_repeat_dom	DMXL2 CFAP251 HIRA WDR3 WDFY3 LRBA WDSUB1	1.61e-03	297	107	7	IPR017986
Domain	G_GB1_RHD3_dom	GBP7 GBP4	1.73e-03	11	107	2	IPR030386
Domain	Guanylate-bd_C	GBP7 GBP4	1.73e-03	11	107	2	IPR003191
Domain	GBP	GBP7 GBP4	1.73e-03	11	107	2	PF02263
Domain	Guanylate-bd_N	GBP7 GBP4	1.73e-03	11	107	2	IPR015894
Domain	G_GB1_RHD3	GBP7 GBP4	1.73e-03	11	107	2	PS51715
Domain	-	INTS7 NF1 TERB1 TTI1 WDFY3 LRBA	1.76e-03	222	107	6	1.25.10.10
Domain	EGF_3	FAT4 ZAN LRP1B BMP1 FAT2 TLL2	2.34e-03	235	107	6	PS50026
Domain	EGF	FAT4 ZAN LRP1B BMP1 FAT2 TLL2	2.34e-03	235	107	6	SM00181
Domain	EGF_Ca-bd_CS	FAT4 LRP1B BMP1 TLL2	2.34e-03	97	107	4	IPR018097
Domain	EGF_CA	FAT4 LRP1B BMP1 TLL2	2.53e-03	99	107	4	PS01187
Domain	-	DMXL2 CFAP251 HIRA WDR3 WDFY3 LRBA WDSUB1	3.06e-03	333	107	7	2.130.10.10
Domain	EGF-like_dom	FAT4 ZAN LRP1B BMP1 FAT2 TLL2	3.11e-03	249	107	6	IPR000742
Domain	WD40/YVTN_repeat-like_dom	DMXL2 CFAP251 HIRA WDR3 WDFY3 LRBA WDSUB1	3.16e-03	335	107	7	IPR015943
Domain	EGF-type_Asp/Asn_hydroxyl_site	FAT4 LRP1B BMP1 TLL2	3.23e-03	106	107	4	IPR000152
Domain	Quinoprotein_ADH-like_supfam	DMXL2 CFAP251 WDSUB1	3.48e-03	53	107	3	IPR011047
Domain	EGF_1	FAT4 ZAN LRP1B BMP1 FAT2 TLL2	3.50e-03	255	107	6	PS00022
Domain	EGF-like_CS	FAT4 ZAN LRP1B BMP1 FAT2 TLL2	3.92e-03	261	107	6	IPR013032
Domain	EGF_2	FAT4 ZAN LRP1B BMP1 FAT2 TLL2	4.22e-03	265	107	6	PS01186
Domain	ARM-like	INTS7 NF1 TERB1 TTI1 WDFY3 LRBA	4.62e-03	270	107	6	IPR011989
Pubmed	Acetylation-Mimic Mutation of TRIM28-Lys304 to Gln Attenuates the Interaction with KRAB-Zinc-Finger Proteins and Affects Gene Expression in Leukemic K562 Cells.	ZNF354A ZNF626 ZNF253 ZNF558 CENPV ZNF90 YTHDF2	1.98e-06	181	111	7	37372979
Pubmed	RTP family members induce functional expression of mammalian odorant receptors.	REEP1 REEP2 REEP4	3.74e-06	10	111	3	15550249
Pubmed	Inherited ACTH insensitivity illuminates the mechanisms of ACTH action.	REEP1 REEP2 REEP4	3.74e-06	10	111	3	16271481
Pubmed	Staphylococcus aureus biofilms prevent macrophage phagocytosis and attenuate inflammation in vivo.	TLR9 TLR2	1.01e-05	2	111	2	21525381
Pubmed	The guanylate-binding proteins: emerging insights into the biochemical properties and functions of this family of large interferon-induced guanosine triphosphatase.	GBP7 GBP4	1.01e-05	2	111	2	21142871
Pubmed	TLR2 and TLR9 synergistically control herpes simplex virus infection in the brain.	TLR9 TLR2	1.01e-05	2	111	2	19050280
Pubmed	Chronic hypersensitivity pneumonitis caused by Saccharopolyspora rectivirgula is not associated with a switch to a Th2 response.	TLR9 TLR2	1.01e-05	2	111	2	26719148
Pubmed	Toll-like receptor 2 induces Th17 myeloperoxidase autoimmunity while Toll-like receptor 9 drives Th1 autoimmunity in murine vasculitis.	TLR9 TLR2	1.01e-05	2	111	2	21190299
Pubmed	Genetic Polymorphisms of Toll-like receptors 2 and 9 as Susceptibility Factors for the Development of Ankylosing Spondylitis and Psoriatic Arthritis.	TLR9 TLR2	1.01e-05	2	111	2	31781672
Pubmed	[The correlation between polymorphisms of Toll-like receptor 2 and Toll-like receptor 9 and susceptibility to gastric cancer].	TLR9 TLR2	1.01e-05	2	111	2	22041559
Pubmed	Toll-like receptor (TLR) 2 and TLR9 expressed in trigeminal ganglia are critical to viral control during herpes simplex virus 1 infection.	TLR9 TLR2	1.01e-05	2	111	2	20864677
Pubmed	Vaccine-mediated immunity to experimental Mycobacterium tuberculosis is not impaired in the absence of Toll-like receptor 9.	TLR9 TLR2	1.01e-05	2	111	2	26748860
Pubmed	Polymorphisms of toll-like receptors 2 and 9 and severity and prognosis of bacterial meningitis in Chinese children.	TLR9 TLR2	1.01e-05	2	111	2	28202935
Pubmed	Increased expression of toll-like receptors 2 and 9 is associated with reduced DNA methylation in spontaneous preterm labor.	TLR9 TLR2	1.01e-05	2	111	2	28622534
Pubmed	Multicolor flow cytometric analysis of TLR2 and TLR9 expression and function in NK cells from patients with ANCA-associated vasculitis.	TLR9 TLR2	1.01e-05	2	111	2	28834234
Pubmed	Context-Dependent Roles for Toll-Like Receptors 2 and 9 in the Pathogenesis of Staphylococcus aureus Osteomyelitis.	TLR9 TLR2	1.01e-05	2	111	2	36226943
Pubmed	Toll-like receptor 2 suppresses Toll-like receptor 9 responses in Peyer's patch dendritic cells.	TLR9 TLR2	1.01e-05	2	111	2	25638261
Pubmed	Overexpression of TLR2 and TLR9 on monocyte subsets of active rheumatoid arthritis patients contributes to enhance responsiveness to TLR agonists.	TLR9 TLR2	1.01e-05	2	111	2	26759164
Pubmed	Mycobacterium tuberculosis lipoprotein-induced association of TLR2 with protein kinase C zeta in lipid rafts contributes to reactive oxygen species-dependent inflammatory signalling in macrophages.	TLR2 PRKCZ	1.01e-05	2	111	2	18503635
Pubmed	Gbp3 is associated with the progression of lupus nephritis by regulating cell proliferation, inflammation and pyroptosis.	GBP7 GBP4	1.01e-05	2	111	2	37621179
Pubmed	Maintenance of recombinant type A gamma-aminobutyric acid receptor function: role of protein tyrosine phosphorylation and calcineurin.	GABRA1 GABRA3	1.01e-05	2	111	2	9655866
Pubmed	Role of specific innate immune responses in herpes simplex virus infection of the central nervous system.	TLR9 TLR2	1.01e-05	2	111	2	22171256
Pubmed	TLR-2 and TLR-9 are sensors of apoptosis in a mouse model of doxorubicin-induced acute inflammation.	TLR9 TLR2	1.01e-05	2	111	2	21311566
Pubmed	Synonymous mutations in TLR2 and TLR9 genes decrease COPD susceptibility in the Chinese Han population.	TLR9 TLR2	1.01e-05	2	111	2	37585174
Pubmed	TLR2, TLR4 and TLR9 genotypes and haplotypes in the susceptibility to and clinical course of Chlamydia trachomatis infections in Dutch women.	TLR9 TLR2	1.01e-05	2	111	2	26568059
Pubmed	Association of Toll-like receptor 9 haplotypes with chronic periodontitis in Czech population.	TLR9 TLR2	1.01e-05	2	111	2	20041977
Pubmed	Association of Toll like receptor 2 and 9 gene variants with pulmonary tuberculosis: exploration in a northern Indian population.	TLR9 TLR2	1.01e-05	2	111	2	29675696
Pubmed	Important role for Toll-like receptor 9 in host defense against meningococcal sepsis.	TLR9 TLR2	1.01e-05	2	111	2	18794294
Pubmed	Dual TLR2/9 Recognition of Herpes Simplex Virus Infection Is Required for Recruitment and Activation of Monocytes and NK Cells and Restriction of Viral Dissemination to the Central Nervous System.	TLR9 TLR2	1.01e-05	2	111	2	29760708
Pubmed	Leishmania expressed lipophosphoglycan interacts with Toll-like receptor (TLR)-2 to decrease TLR-9 expression and reduce anti-leishmanial responses.	TLR9 TLR2	1.01e-05	2	111	2	23600828
Pubmed	A study of the expression and localization of toll-like receptors 2 and 9 in different grades of cervical intraepithelial neoplasia and squamous cell carcinoma.	TLR9 TLR2	1.01e-05	2	111	2	26569074
Pubmed	Toll-like receptors-2 and -9 (TLR2 and TLR9) gene polymorphism in patients with type 2 diabetes and diabetic foot.	TLR9 TLR2	1.01e-05	2	111	2	28445304
Pubmed	Toll-like receptor expression and activation in astroglia: differential regulation by HIV-1 Tat, gp120, and morphine.	TLR9 TLR2	1.01e-05	2	111	2	21425908
Pubmed	Bacterial amyloid curli acts as a carrier for DNA to elicit an autoimmune response via TLR2 and TLR9.	TLR9 TLR2	1.01e-05	2	111	2	28410407
Pubmed	Diminished TLR2-TLR9 mediated CD4+ T cell responses are associated with increased inflammation in intraocular tuberculosis.	TLR9 TLR2	1.01e-05	2	111	2	30218032
Pubmed	Insufficient TLR activation contributes to the slow development of CD8+ T cell responses in Trypanosoma cruzi infection.	TLR9 TLR2	1.01e-05	2	111	2	19553540
Pubmed	Toll-like receptor 2 and 9 genetic polymorphisms and the susceptibility to B cell Non-Hodgkin Lymphoma in Egypt.	TLR9 TLR2	1.01e-05	2	111	2	24912772
Pubmed	Altered cortical GABAA receptor composition, physiology, and endocytosis in a mouse model of a human genetic absence epilepsy syndrome.	GABRA1 GABRA3	1.01e-05	2	111	2	23744069
Pubmed	Differential use of TLR2 and TLR9 in the regulation of immune responses during the infection with Trypanosoma cruzi.	TLR9 TLR2	1.01e-05	2	111	2	23650544
Pubmed	Lactoferrin suppresses the Epstein-Barr virus-induced inflammatory response by interfering with pattern recognition of TLR2 and TLR9.	TLR9 TLR2	1.01e-05	2	111	2	25068657
Pubmed	TLR9 played a more important role than TLR2 in the combination of maltose-binding protein and BCG-induced Th1 activation.	TLR9 TLR2	1.01e-05	2	111	2	27693915
Pubmed	Investigation of TLR2 (-196 to -174del) and TLR9 (T-1486C) Gene Polymorphisms Association with Inflammatory Bowel Diseases.	TLR9 TLR2	1.01e-05	2	111	2	38918662
Pubmed	High expression of Toll-like receptors 2 and 9 and Th1/Th2 cytokines profile in obese asthmatic children.	TLR9 TLR2	1.01e-05	2	111	2	24801457
Pubmed	The Relationship of the TLR9 and TLR2 Genetic Polymorphisms with Cervical Cancer Risk: a Meta-Analysis of Case-Control Studies.	TLR9 TLR2	1.01e-05	2	111	2	30215163
Pubmed	Susceptibility to SLE in South Indian Tamils may be influenced by genetic selection pressure on TLR2 and TLR9 genes.	TLR9 TLR2	1.01e-05	2	111	2	25466615
Pubmed	Toll-like receptor 2 (TLR2) and TLR9 signaling results in HIV-long terminal repeat trans-activation and HIV replication in HIV-1 transgenic mouse spleen cells: implications of simultaneous activation of TLRs on HIV replication.	TLR9 TLR2	1.01e-05	2	111	2	12734363
Pubmed	TLR9 -1237 T/C and TLR2 -194 to -174 del polymorphisms and the risk of Parkinson's disease in the Greek population: a pilot study.	TLR9 TLR2	1.01e-05	2	111	2	22552867
Pubmed	Cloning, expression, and characterization of a novel guanylate-binding protein, GBP3 in murine erythroid progenitor cells.	GBP7 GBP4	1.01e-05	2	111	2	9659399
Pubmed	REEP1 and REEP2 proteins are preferentially expressed in neuronal and neuronal-like exocytotic tissues.	REEP1 REEP2	1.01e-05	2	111	2	24355597
Pubmed	Identification of an evolutionarily conserved superfamily of DOCK180-related proteins with guanine nucleotide exchange activity.	DOCK9 DOCK5 DOCK7	1.12e-05	14	111	3	12432077
Pubmed	CYLD Regulates Centriolar Satellites Proteostasis by Counteracting the E3 Ligase MIB1.	PATZ1 CAPZB HP1BP3 DHX30 HERC2 YTHDF2	2.72e-05	182	111	6	31067453
Pubmed	Synergic activation of toll-like receptor (TLR) 2/6 and 9 in response to Ureaplasma parvum & urealyticum in human amniotic epithelial cells.	TLR9 TLR2	3.02e-05	3	111	2	23593431
Pubmed	TLR2, TLR4 and TLR9 polymorphisms and Crohn's disease in a New Zealand Caucasian cohort.	TLR9 TLR2	3.02e-05	3	111	2	17914947
Pubmed	C-->U editing of neurofibromatosis 1 mRNA occurs in tumors that express both the type II transcript and apobec-1, the catalytic subunit of the apolipoprotein B mRNA-editing enzyme.	APOB NF1	3.02e-05	3	111	2	11727199
Pubmed	Expression of toll-like receptors on antigen-presenting cells in patients with falciparum malaria.	TLR9 TLR2	3.02e-05	3	111	2	17854755
Pubmed	A critical role for type I IFN in arthritis development following Borrelia burgdorferi infection of mice.	TLR9 TLR2	3.02e-05	3	111	2	19050267
Pubmed	Toll-like receptor 2 deficiency results in impaired antibody responses and septic shock during Borrelia hermsii infection.	TLR9 TLR2	3.02e-05	3	111	2	20696824
Pubmed	Deficiency in type I interferon signaling prevents the early interferon-induced gene signature in pancreatic islets but not type 1 diabetes in NOD mice.	TLR9 TLR2	3.02e-05	3	111	2	24353186
Pubmed	Enhanced efficacy of therapeutic cancer vaccines produced by co-treatment with Mycobacterium tuberculosis heparin-binding hemagglutinin, a novel TLR4 agonist.	TLR9 TLR2	3.02e-05	3	111	2	21368092
Pubmed	[Toll-like receptor gene polymorphisms and susceptibility to inflammatory bowel disease in Chinese Han and Caucasian populations].	TLR9 TLR2	3.02e-05	3	111	2	20646633
Pubmed	Structural basis for the substrate specificity of bone morphogenetic protein 1/tolloid-like metalloproteases.	BMP1 TLL2	3.02e-05	3	111	2	18824173
Pubmed	Toll-like receptor (TLR) polymorphisms in African children: Common TLR-4 variants predispose to severe malaria.	TLR9 TLR2	3.02e-05	3	111	2	16371473
Pubmed	Toll-like receptor signaling in anti-cancer immunity.	TLR9 TLR2	3.02e-05	3	111	2	12630564
Pubmed	TLR9 blockade inhibits activation of diabetogenic CD8+ T cells and delays autoimmune diabetes.	TLR9 TLR2	3.02e-05	3	111	2	20393135
Pubmed	Single-nucleotide polymorphisms in the Toll-like receptor pathway increase susceptibility to infections in severely injured trauma patients.	TLR9 TLR2	3.02e-05	3	111	2	23425749
Pubmed	Systemically administered ligands of Toll-like receptor 2, -4, and -9 induce distinct inflammatory responses in the murine lung.	TLR9 TLR2	3.02e-05	3	111	2	21547259
Pubmed	REEPs are membrane shaping adapter proteins that modulate specific g protein-coupled receptor trafficking by affecting ER cargo capacity.	REEP1 REEP2	3.02e-05	3	111	2	24098485
Pubmed	Toll-like receptor stimulation enhances phagocytosis and intracellular killing of nonencapsulated and encapsulated Streptococcus pneumoniae by murine microglia.	TLR9 TLR2	3.02e-05	3	111	2	19933834
Pubmed	Polymorphisms in toll-like receptor genes and susceptibility to pulmonary aspergillosis.	TLR9 TLR2	3.02e-05	3	111	2	18275280
Pubmed	Innate immunity mediated by TLR9 modulates pathogenicity in an animal model of multiple sclerosis.	TLR9 TLR2	3.02e-05	3	111	2	16440059
Pubmed	The nucleosome (histone-DNA complex) is the TLR9-specific immunostimulatory component of Plasmodium falciparum that activates DCs.	TLR9 TLR2	3.02e-05	3	111	2	21687712
Pubmed	Polymorphisms in Toll-like receptor genes and susceptibility to infections in allogeneic stem cell transplantation.	TLR9 TLR2	3.02e-05	3	111	2	19539691
Pubmed	Toll-like receptor 2 regulates CXC chemokine production and neutrophil recruitment to the cornea in Onchocerca volvulus/Wolbachia-induced keratitis.	TLR9 TLR2	3.02e-05	3	111	2	17875630
Pubmed	Polymorphisms in Toll-like receptors 2, 4, and 9 are highly associated with hearing loss in survivors of bacterial meningitis.	TLR9 TLR2	3.02e-05	3	111	2	22662111
Pubmed	Impaired Surface Expression of HLA-DR, TLR2, TLR4, and TLR9 in Ex Vivo-In Vitro Stimulated Monocytes from Severely Injured Trauma Patients.	TLR9 TLR2	3.02e-05	3	111	2	28255201
Pubmed	Association between genetic variants of TLR2, TLR4, TLR9 and schizophrenia.	TLR9 TLR2	3.02e-05	3	111	2	37718198
Pubmed	Genetic analysis of the role of proteolysis in the activation of latent myostatin.	BMP1 TLL2	3.02e-05	3	111	2	18286185
Pubmed	Evaluation of the detection of Toll-like receptors (TLRs) in cancer development and progression in patients with colorectal cancer.	TLR9 TLR2	3.02e-05	3	111	2	29883450
Pubmed	Association of toll-like receptor gene polymorphisms and its interaction with HPV infection in determining the susceptibility of cervical cancer in Chinese Han population.	TLR9 TLR2	3.02e-05	3	111	2	28497211
Pubmed	Live Streptococcus pneumoniae, Haemophilus influenzae, and Neisseria meningitidis activate the inflammatory response through Toll-like receptors 2, 4, and 9 in species-specific patterns.	TLR9 TLR2	3.02e-05	3	111	2	16731773
Pubmed	Heat shock protein gp96 regulates Toll-like receptor 9 proteolytic processing and conformational stability.	HSP90B2P TLR9	3.02e-05	3	111	2	22554506
Pubmed	Quantitative defects in invariant NKT cells and TLR responses in patients with hyper-IgE syndrome.	TLR9 TLR2	3.02e-05	3	111	2	25796310
Pubmed	Genetic alterations within TLR genes in development of Toxoplasma gondii infection among Polish pregnant women.	TLR9 TLR2	3.02e-05	3	111	2	28500897
Pubmed	Extracts of Larix Leptolepis effectively augments the generation of tumor antigen-specific cytotoxic T lymphocytes via activation of dendritic cells in TLR-2 and TLR-4-dependent manner.	TLR9 TLR2	3.02e-05	3	111	2	22677561
Pubmed	Influence of genetic variability in toll-like receptors (TLR 2, TLR 4, and TLR 9) on human immunodeficiency virus-1 disease progression.	TLR9 TLR2	3.02e-05	3	111	2	36926756
Pubmed	Toll-like receptors in alcoholic liver disease, non-alcoholic steatohepatitis and carcinogenesis.	TLR9 TLR2	3.02e-05	3	111	2	23855294
Pubmed	Regulation of contact sensitivity in non-obese diabetic (NOD) mice by innate immunity.	TLR9 TLR2	3.02e-05	3	111	2	29943459
Pubmed	Analysis of TLR2, TLR4, and TLR9 single nucleotide polymorphisms in children with bacterial meningitis and their healthy family members.	TLR9 TLR2	3.02e-05	3	111	2	28487240
Pubmed	Toll-like receptors 2, 4 and 9 and hypoxia markers HIF-1alpha and CAIX in pancreatic intraepithelial neoplasia.	TLR9 TLR2	3.02e-05	3	111	2	30357962
Pubmed	Specific GABAA circuits for visual cortical plasticity.	GABRA1 GABRA3	3.02e-05	3	111	2	15017002
Pubmed	Severity of doxorubicin-induced small intestinal mucositis is regulated by the TLR-2 and TLR-9 pathways.	TLR9 TLR2	3.02e-05	3	111	2	21960132
Pubmed	Immunohistochemical study of toll-like receptors 2, 4, and 9 expressions in pemphigus and bullous pemphigoid lesions.	TLR9 TLR2	3.02e-05	3	111	2	27221282
Pubmed	Enhanced expression of Toll-like receptors 2 and 4, but not 9, in spleen tissue from patients with visceral leishmaniasis.	TLR9 TLR2	3.02e-05	3	111	2	25244363
Pubmed	Toll-like receptor 9 is required for full host resistance to Mycobacterium avium infection but plays no role in induction of Th1 responses.	TLR9 TLR2	3.02e-05	3	111	2	21300776
Pubmed	TLR2, TLR4 and TLR9 are differentially modulated in liver lethally injured from BALB/c and C57BL/6 mice during Trypanosoma cruzi acute infection.	TLR9 TLR2	3.02e-05	3	111	2	18565585
Pubmed	Influence of the Toll-like receptor 9 1635A/G polymorphism on the CD4 count, HIV viral load, and clinical progression.	TLR9 TLR2	3.02e-05	3	111	2	18769358
Pubmed	Role of Toll-like receptors 2, 4, and 9 in mediating neutrophil dysfunction in alcoholic hepatitis.	TLR9 TLR2	3.02e-05	3	111	2	19033535
Pubmed	Toll-like receptor TLR2 and TLR9 ligation triggers neutrophil activation in granulomatosis with polyangiitis.	TLR9 TLR2	3.02e-05	3	111	2	23407387
Pubmed	Dual recognition of herpes simplex viruses by TLR2 and TLR9 in dendritic cells.	TLR9 TLR2	3.02e-05	3	111	2	17085599
Pubmed	TLR9 regulates Th1 responses and cooperates with TLR2 in mediating optimal resistance to Mycobacterium tuberculosis.	TLR9 TLR2	3.02e-05	3	111	2	16365150
Cytoband	Ensembl 112 genes in cytogenetic band chr19p12	ZNF429 ZNF626 ZNF66 ZNF90	2.28e-04	122	111	4	chr19p12
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF354A ZNF266 ZNF268 PATZ1 ZNF429 ZNF407 ZNF626 ZNF891 ZNF800 SALL1 ZNF253 ZNF558 SCAPER ZNF727 ZNF470 ZNF528 ZNF30 ZNF90 ZNF541	3.55e-10	718	82	19	28
GeneFamily	Receptor accessory proteins	REEP1 REEP2 REEP4	1.78e-06	6	82	3	717
GeneFamily	WD repeat domain containing	DMXL2 CFAP251 HIRA WDR3 WDFY3 LRBA WDSUB1	1.87e-04	262	82	7	362
GeneFamily	Bone morphogenetic proteins\|Astacins	BMP1 TLL2	3.01e-04	6	82	2	894
GeneFamily	WD repeat domain containing\|BEACH domain containing	WDFY3 LRBA	7.17e-04	9	82	2	1230
GeneFamily	CD molecules\|Toll like receptors	TLR9 TLR2	8.93e-04	10	82	2	948
GeneFamily	Cadherin related	FAT4 FAT2	2.64e-03	17	82	2	24
GeneFamily	EF-hand domain containing	CACNA1E DGKA S100A5 PLCH2 ANKEF1	3.19e-03	219	82	5	863
GeneFamily	Gamma-aminobutyric acid type A receptor subunits	GABRA1 GABRA3	3.30e-03	19	82	2	563
ToppCell	Parenchymal-NucSeq\|Parenchymal / Cell types per location group and 10X technology with lineage, and cell group designations	ZNF407 NF1 SCAPER EXOC6B WDFY3 LRBA VPS13B PDZD2	3.41e-08	198	110	8	1996373bdccc55aac347d349bd22f6aad6d0c668
ToppCell	Tracheal-NucSeq\|Tracheal / Cell types per location group and 10X technology with lineage, and cell group designations	UBR2 ZNF407 NF1 SCAPER EXOC6B WDFY3 LRBA VPS13B	3.54e-08	199	110	8	94b94b17ca18b8dc27b91da1f2ccf89e03cc7035
ToppCell	Bronchial-NucSeq\|Bronchial / Cell types per location group and 10X technology with lineage, and cell group designations	ZNF407 SCAPER EXOC6B LRBA VPS13B PDZD2	9.31e-06	196	110	6	ab53c742866945545a92e2e61850d63c80d9a2a6
Disease	hereditary spastic paraplegia 31 (implicated_via_orthology)	REEP1 REEP2 REEP4	8.20e-07	6	103	3	DOID:0110782 (implicated_via_orthology)
Disease	Bipolar Disorder	CNTN4 MCHR1 DOCK9 TLL2 TLR2 PRKCZ CDH17 GABRA1 GABRA3	4.58e-05	477	103	9	C0005586
Disease	white matter microstructure measurement	MAN1A1 KMT2B DOCK9 APCS APOB DOCK5 SCAPER WDFY3	6.91e-05	390	103	8	EFO_0005674
Disease	triacylglycerol 54:8 measurement	CNTN4 ZNF487 GPR12	6.95e-05	23	103	3	EFO_0010426
Disease	obsolete_red blood cell distribution width	CFAP251 KMT2B PATZ1 ZNF407 APOB HP1BP3 DOCK5 ZNF800 GPR158 SCAPER RMND1 ZC3H7B WDSUB1 MAST3	2.46e-04	1347	103	14	EFO_0005192
Disease	cutaneous leishmaniasis (is_marker_for)	TLR9 TLR2	5.33e-04	10	103	2	DOID:9111 (is_marker_for)
Disease	Asthma, Occupational	HERC2 CDH17	5.33e-04	10	103	2	C0264423
Disease	meningitis	CACNA1E SCAPER	6.50e-04	11	103	2	MONDO_0021108
Disease	gallbladder cancer (is_implicated_in)	APOB LRP1B	9.18e-04	13	103	2	DOID:3121 (is_implicated_in)
Disease	carcinoma (implicated_via_orthology)	FAT4 SALL1 PRKCZ	1.47e-03	64	103	3	DOID:305 (implicated_via_orthology)
Disease	MAJOR AFFECTIVE DISORDER 2	PRKCZ CDH17	1.59e-03	17	103	2	C1839839
Disease	allergic rhinitis (is_marker_for)	TLR9 TLR2	1.59e-03	17	103	2	DOID:4481 (is_marker_for)
Disease	dermatomyositis (is_marker_for)	TLR9 TLR2	1.59e-03	17	103	2	DOID:10223 (is_marker_for)
Disease	perinatal necrotizing enterocolitis (biomarker_via_orthology)	TLR9 TLR2	1.59e-03	17	103	2	DOID:8677 (biomarker_via_orthology)
Disease	sinusitis (is_marker_for)	TLR9 TLR2	1.78e-03	18	103	2	DOID:0050127 (is_marker_for)
Disease	complex trait	DMXL2 ZAN APCS APOB DOCK7	2.65e-03	271	103	5	EFO_0010578
Disease	proprotein convertase subtilisin/kexin type 9 measurement	APOB ZNF528	2.66e-03	22	103	2	EFO_0009312
Disease	leptin measurement	LRP1B ZNF800 PDZD2	2.89e-03	81	103	3	EFO_0005000
Disease	goiter	CAPZB SALL1	2.91e-03	23	103	2	EFO_0004283

Protein segments in the cluster

Peptide	Gene	Start	Entry
SIKSAKVDGVSYFRH	CACNA1E	446	Q15878
SHYVTTRKGVSTLAI	GPR12	241	P47775
VSHYVLTIKSSDKGS	FAT4	2736	Q6V0I7
STKITNLKGSVLYHL	CNTN4	861	Q8IWV2
VVHLNSLITSGYTKK	ANKEF1	701	Q9NU02
KSAFTTVLTVSHKFR	DMXL2	631	Q8TDJ6
VTYRTKSGNILLHKS	DHX30	1046	Q7L2E3
DDTITKKGFHLRYTS	BMP1	961	P13497
VQEKSSGRTAHYKLT	CAPZB	156	P47756
YSHLKLGAIRTLSFS	CFAP251	536	Q8TBY9
SGASVVAIRKYIIHK	HP1BP3	176	Q5SSJ5
AESLKFYHKGIASLT	INTS7	591	Q9NVH2
ATLRITGYKSHAKEI	NSUN2	76	Q08J23
LTLYKHTATVDGKTI	RABL2A	56	Q9UBK7
GISTNYHASRKKTFE	HSP90B2P	311	Q58FF3
THFYKLGVKTTGFIR	LRP1B	2631	Q9NZR2
GKSSSVTRLYKAHTV	MYO15A	1756	Q9UKN7
YGTVTLKLHRVLKVF	GPR158	496	Q5T848
ALSSYVVKKVAVHSG	HERC2	3041	O95714
VLYHLTSSISDGTKK	FSIP2	3506	Q5CZC0
HTAKYLLRVTASDGK	FAT2	2976	Q9NYQ8
EYHIVKKSTRSLSTT	PDZD2	556	O15018
STYAKSRKDIGVQSH	DGKA	256	P23743
DSYKVTTGKLHVSLT	PNPLA1	111	Q8N8W4
LVIGYSLEKSSKSHV	LRBA	526	P50851
YIFTHAKTKTLREGI	GBP4	286	Q96PP9
YIFTHAKTKTLREGI	GBP7	271	Q8N8V2
TTHFHLKRKIGYFVI	GABRA3	266	P34903
TTHFHLKRKIGYFVI	GABRA1	241	P14867
KTSKEAVGVYRSAIH	KMT2B	2571	Q9UMN6
ETVHTTKLYGTTTFK	EXOC6B	586	Q9Y2D4
TKLYGTTTFKDARHA	EXOC6B	591	Q9Y2D4
TVKLKTFSEHLTSYI	PPP1R21	336	Q6ZMI0
HKLRKVSATSSIAVY	FAM182B	66	Q5T319
NRGFSSASYLKVHVK	PATZ1	501	Q9HBE1
VYLIHIGRSKTKSES	OTOP1	331	Q7RTM1
ESVKFSSKYLRTEHG	APOB	2826	P04114
RKHKYLSSSGEVFAL	DOCK5	1181	Q9H7D0
FKRKTILTTSHAFPY	DOCK7	1961	Q96N67
YTGKKSFVRTHLQVI	DOCK9	1511	Q9BZ29
RFKLLKGAEHITTYT	CENPV	191	Q7Z7K6
IVIHSSGKKYGFSLR	MAST3	951	O60307
YLATVHPISSTKFRK	MCHR1	211	Q99705
THLIRKSSSGLTYIA	MAN1A1	446	P33908
GFKSHVKVSRVVNTY	MBIP	206	Q9NS73
KSRIHQSTYGKSLAI	HIRA	371	P54198
FTGSSKILYHIIKGD	CDH17	481	Q12864
TAKKLQHTYRLTSDG	ERVFC1	121	P60507
ISSEVYLFSHVKGRK	SCAPER	801	Q9BY12
RAFTTKGNLKTHYSV	SALL1	741	Q9NSC2
TKGASLLYRKFVHPS	REEP4	81	Q9H6H4
HKCIYKGRSVSLTTF	JARID2	811	Q92833
VTHLYFGRSVSKVVL	FBXL21P	316	Q9UKT6
FKITLTHTLYDVKSG	KIF13B	226	Q9NQT8
KYIVSGKIFSSHSET	TAAR3P	321	Q9P1P4
THAGSKYIRTAFPTK	TATDN1	231	Q6P1N9
LEHGTSLKTLYRKSA	NCOA7	811	Q8NI08
SSYEVVHRILKGKIT	TDRD10	321	Q5VZ19
TELYRTGKKSHLRKT	HS2ST1	276	Q7LGA3
KILKRHFSSVSTETF	RMND1	121	Q9NWS8
KSGHTSLTIIFIVVY	SLC41A2	491	Q96JW4
TKGSSLLYRKFVHPT	REEP1	81	Q9H902
ISSSKSGERHLYLIK	GTF3C3	576	Q9Y5Q9
FSKLRRTTKTKGHSY	THAP7	96	Q9BT49
TTHLGSRRKFAISIY	CLECL1	36	Q8IZS7
SYRAVHTKVFSGSSK	C10orf90	411	Q96M02
LRTKVAKLLGYSTHA	NLN	286	Q9BYT8
HSYHITKFRIKGSIQ	PIH1D2	146	Q8WWB5
KTISGSYQLTVHKSI	ZNF30	211	P17039
GKAFTYSSTLISHKR	ZNF727	346	A8MUV8
GKAFRSKSYLIIHTR	ZNF268	506	Q14587
HYRISKSLVKSAEGS	WDFY3	1001	Q8IZQ1
TKGSSVLYRKFVHPT	REEP2	81	Q9BRK0
SLYIGRHKVTSKVIE	APCS	91	P02743
SVYGSRKTLFVLAHT	TLR9	926	Q9NR96
HGYTLTSKILFKDVI	PLCH2	386	O75038
TTLGTLIKERKIYHT	STOX1	166	Q6ZVD7
TVLGSHLIYKKRISN	STOX1	481	Q6ZVD7
GKSFSSRSYLTIHKR	ZNF558	186	Q96NG5
GKSFSSSFSLTVHKR	ZNF558	326	Q96NG5
DTINKKGFHARYTST	TLL2	991	Q9Y6L7
KSGTVFHLNTLSYIK	ZNF470	176	Q6ECI4
ISKYKFSLVISGLTT	NF1	46	P21359
RYKHFKVTTTSIESP	ZDHHC17	571	Q8IUH5
KYSSTLTTHKRIHTG	ZNF626	351	Q68DY1
TYKTRHTGINLFKCI	ZNF253	161	O75346
GRAFISSSILYVHKI	ZNF90	291	Q03938
SIIKTYEIFETSHGK	TSSK1B	71	Q9BXA7
HGFLSLTYTKAVTKN	VPS13B	1446	Q7Z7G8
GKVFTYSSTLTRHKR	ZNF429	431	Q86V71
GKVFRYKSSLTSHHR	ZNF528	471	Q3MIS6
KSVKVPIYDFTTHSR	UCKL1	176	Q9NWZ5
GKVFKYLSSLSTHKI	ZNF66	291	Q6ZN08
VHKKSSRYLGKITAS	ZNF800	541	Q2TB10
FHKYSGREGSKLTLS	S100A5	16	P33763
GKAFTLSTSLYKHLR	ZNF354A	276	O60765
FYKTRSSTVLTRHIK	ZNF407	711	Q9C0G0
FTHILGFELKYKSTL	WDSUB1	221	Q8N9V3
RTTHSLLSSGTRKYV	TRAPPC10	946	P48553
VTFNGHKAAITTLKY	WDR3	101	Q9UNX4
TTFGTATYKVGLKVH	UBR2	1306	Q8IWV8
YKTLGETSLFSHLTK	TLR2	136	O60603
TSTFHSLKDYVSVRK	TRIM64B	161	A6NI03
TYALVGHSTTKAAAK	UNC5C	666	O95185
TFGIVLSKYHIVSKL	TERB1	286	Q8NA31
KSFGTSSYLIVHKRI	ZNF891	411	A8MT65
LKIIASYKHTTSIFD	YTHDF2	541	Q9Y5A9
GKTFYQKSSLTTHQR	ZNF487	361	B1APH4
KQGHSIVVSSLKIFY	TTI1	226	O43156
GKVFSSASSLSKHYL	ZNF541	146	Q9H0D2
LVHIVRSTSLKYSKI	ZC3H7B	591	Q9UGR2
YASVLGSIRKHTLFS	ZAN	306	Q9Y493
YGVDFLTLHKKTSTG	ZNF266	111	Q14584
GIAYISSSRKHDSIK	PRKCZ	211	Q05513
IHLKKYQIFSGTSKR	NMI	241	Q13287