Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionfatty-acyl-CoA synthase activity

ACSM4 ACSM3

2.94e-058212GO:0004321
GeneOntologyMolecularFunctionmedium-chain fatty acid-CoA ligase activity

ACSM4 ACSM3

5.76e-0511212GO:0031956
GeneOntologyMolecularFunctionC-acyltransferase activity

ACSM4 ACSM3

2.19e-0421212GO:0016408
GeneOntologyMolecularFunctionfatty acid ligase activity

ACSM4 ACSM3

3.37e-0426212GO:0015645
GeneOntologyMolecularFunctionCoA-ligase activity

ACSM4 ACSM3

3.64e-0427212GO:0016405
GeneOntologyMolecularFunctionacid-thiol ligase activity

ACSM4 ACSM3

4.81e-0431212GO:0016878
GeneOntologyMolecularFunctionligase activity, forming carbon-sulfur bonds

ACSM4 ACSM3

8.43e-0441212GO:0016877
MousePhenocurly tail

TBXT TRAF4 CELSR1

4.20e-0557173MP:0003051
MousePhenospina bifida occulta

TBXT TRAF4

1.45e-0415172MP:0005297
DomainAMP-bd_C

ACSM4 ACSM3

1.62e-0417212IPR025110
DomainAMP-binding_C

ACSM4 ACSM3

1.62e-0417212PF13193
DomainAMP-binding_CS

ACSM4 ACSM3

3.85e-0426212IPR020845
DomainAMP_BINDING

ACSM4 ACSM3

4.47e-0428212PS00455
DomainAMP-binding

ACSM4 ACSM3

5.14e-0430212PF00501
DomainAMP-dep_Synth/Lig

ACSM4 ACSM3

5.14e-0430212IPR000873
DomainHEAT_REPEAT

HEATR1 PSME4

2.78e-0370212PS50077
DomainGrowth_fac_rcpt_

CELSR1 EPHA1

1.31e-02156212IPR009030
Domainfn3

EPHA1 ROBO3

1.41e-02162212PF00041
Pubmed

The novel mouse mutant, chuzhoi, has disruption of Ptk7 protein and exhibits defects in neural tube, heart and lung development and abnormal planar cell polarity in the ear.

TBXT CELSR1

1.25e-05921220704721
Pubmed

Cofilin and Vangl2 cooperate in the initiation of planar cell polarity in the mouse embryo.

TBXT CELSR1

2.28e-051221223406901
Pubmed

A systematic, genome-wide, phenotype-driven mutagenesis programme for gene function studies in the mouse.

TBXT CELSR1

4.15e-051621210932191
Pubmed

An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.

SF3A3 TMEM30A ZNF106 USP54 SEC16A

6.31e-0573321534672954
Pubmed

Chato, a KRAB zinc-finger protein, regulates convergent extension in the mouse embryo.

TBXT CELSR1

7.24e-052121218701545
Pubmed

β-catenin regulates Pax3 and Cdx2 for caudal neural tube closure and elongation.

TBXT CELSR1

7.24e-052121224284205
Pubmed

USP39 is essential for mammalian epithelial morphogenesis through upregulation of planar cell polarity components.

TBXT CELSR1

7.96e-052221235440748
Pubmed

Tectonic, a novel regulator of the Hedgehog pathway required for both activation and inhibition.

TCTN3 TBXT

8.72e-052321216357211
Pubmed

STRAP regulates alternative splicing fidelity during lineage commitment of mouse embryonic stem cells.

SF3A3 TBXT

2.16e-043621233230114
Pubmed

Histone methyltransferase DOT1L coordinates AR and MYC stability in prostate cancer.

TRAF4 USP54 SEC16A

5.20e-0426421332814769
InteractionARHGEF39 interactions

TRAF4 HEATR1 SEC16A

2.61e-0556213int:ARHGEF39
InteractionBRICD5 interactions

TMEM30A CELSR1 EPHA1 ERO1B

4.38e-05194214int:BRICD5
InteractionTLCD2 interactions

TMEM30A TCTN3

5.66e-0511212int:TLCD2
InteractionTMEM106A interactions

TMEM30A TCTN3 CELSR1 EPHA1

6.42e-05214214int:TMEM106A
InteractionSFTPC interactions

TMEM30A TCTN3 CELSR1 EPHA1

7.40e-05222214int:SFTPC
GeneFamilyAcyl-CoA synthetase family

ACSM4 ACSM3

2.06e-042615240
GeneFamilyFibronectin type III domain containing

EPHA1 ROBO3

7.58e-03160152555
ToppCellIonocyte-iono-2|World / Class top

ACSM3 OSBPL1A NAPEPLD

7.06e-05173213e5ec28ccc5e048fd98de4c876e5c53b866b66228
ToppCell343B-Lymphocytic-NK_cells-NK_cell_D|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

SF3A3 ZNF106 ROBO3

8.21e-05182213c6172aca2475bf0948a78e39f0dae6388504a915
ToppCellChildren_(3_yrs)-Epithelial-club_cell-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

TRAF4 CELSR1 USP54

8.21e-05182213215c303df42f13597b2c7a95cb157c6bc7aca9a1
ToppCellnormal_Lung-Myeloid_cells-pDCs|Myeloid_cells / Location, Cell class and cell subclass

TRAF4 HEATR1 ERO1B

8.89e-05187213a3592f056e1c2f82ba325fea2ecc4dd6c6347c81
ToppCell5'-GW_trimst-2-LymphNode-Mesenchymal-Pericytes-angiogenic_pericyte|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

DCLK3 THSD7B OSBPL1A

8.89e-05187213b8f88599e22b9b345c7ec3bbecd87a8b2a033f9f
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

SLC17A3 CELSR1 ACSM3

8.89e-051872139d77ca45f7563bd6f2a0c1be5d99d93ad30983f7
ToppCell10x3'2.3-week_17-19-Lymphocytic_B-B_lineage-immature_B_cell|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

ZNF106 TRAF4 ERO1B

1.02e-041962139a6e4eea19348a6e3379d3b872456ab6280cb74f
ToppCellwk_08-11-Epithelial|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

TRAF4 CELSR1 ACSM3

1.08e-04200213445fc7995ffc440c6256a6aab0bbf33fb0fea028
DiseaseNEURAL TUBE DEFECTS, SUSCEPTIBILITY TO

TBXT CELSR1

1.35e-058212C3891448
Diseasevisceral heterotaxy (implicated_via_orthology)

OSBPL1A PSME4

3.16e-0437212DOID:0050545 (implicated_via_orthology)
DiseaseHIV Coinfection

SF3A3 PSME4

2.43e-03103212C4505456
DiseaseHIV Infections

SF3A3 PSME4

2.43e-03103212C0019693
Diseaseattention function measurement

ZNF106 HEATR1

4.93e-03148212EFO_0007636
Diseaseneuroimaging measurement

SLC17A3 ZNF106 CELSR1 ROBO3

6.26e-031069214EFO_0004346
Diseasevery low density lipoprotein cholesterol measurement, cholesterol:total lipids ratio

ZNF106 SEC16A

1.08e-02222212EFO_0008317, EFO_0020943
Diseaseupper aerodigestive tract neoplasm

HEATR1 ERO1B

1.31e-02246212EFO_0004284
Diseasevery low density lipoprotein cholesterol measurement, cholesteryl esters:total lipids ratio

ZNF106 SEC16A

1.50e-02264212EFO_0008317, EFO_0020944

Protein segments in the cluster

PeptideGeneStartEntry
GWLLDPPKDGWSEQQ

EPHA1

41

P21709
WGKPSWGPNIKEFKH

ERO1B

271

Q86YB8
RPANPALWWVNGKGD

ACSM4

71

P0C7M7
ENKLDLPCPRGWWGN

CELSR1

1946

Q9NYQ6
GGQFAIWEKWGPPQE

SLC17A3

106

O00476
TQKKWGRGKWEPEPS

DCLK3

91

Q9C098
EEDWKTRWFHQGPNP

OSBPL1A

911

Q9BXW6
WWTDKNVKFRNPPGG

TMEM30A

206

Q9NV96
KAPKSFPKGDIWWNP

HEATR1

801

Q9H583
FPKGDIWWNPEQLKE

HEATR1

806

Q9H583
KKPSNPAFWWINRNG

ACSM3

76

Q53FZ2
EPKKGESWFFRWLPG

SEC16A

2101

O15027
GNPQPSVRWKKDGQW

ROBO3

476

Q96MS0
RWKYVNGEWVPGGKP

TBXT

101

O15178
DPNWKNFQKPGTWRG

TRAF4

411

Q9BUZ4
FPIKDWGKPGDLWNL

PSME4

751

Q14997
EFEKKWENGTFPGWP

SF3A3

216

Q12874
GKKDNQFIWKPGPWG

THSD7B

36

Q9C0I4
PRGQPKMDWKWPFDF

TCTN3

556

Q6NUS6
GPPQRDWKWEKDGFN

ZNF106

126

Q9H2Y7
PFSQGQEKGHWPWAK

USP54

1171

Q70EL1
KDGRFVNPWPTWKNP

NAPEPLD

61

Q6IQ20