Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionstructural constituent of postsynaptic actin cytoskeleton

POTEE POTEF ACTB ACTG1 POTEKP POTEI

4.28e-1311656GO:0098973
GeneOntologyMolecularFunctionstructural constituent of postsynapse

POTEE POTEF ACTB ACTG1 POTEKP POTEI

7.97e-1032656GO:0099186
GeneOntologyMolecularFunctionstructural constituent of synapse

POTEE POTEF ACTB ACTG1 POTEKP POTEI

4.50e-0942656GO:0098918
GeneOntologyMolecularFunctionstructural constituent of cytoskeleton

POTEE ANK3 POTEF ACTB ACTG1 POTEKP POTEI

2.14e-07130657GO:0005200
GeneOntologyMolecularFunctionG-protein activated inward rectifier potassium channel activity

KCNJ5 KCNJ9

6.23e-054652GO:0015467
GeneOntologyMolecularFunctionmolybdenum ion binding

XDH MTARC2

1.55e-046652GO:0030151
GeneOntologyMolecularFunctionmolybdopterin cofactor binding

XDH MTARC2

1.55e-046652GO:0043546
GeneOntologyMolecularFunctionpiRNA binding

MOV10L1 PIWIL4

1.55e-046652GO:0034584
GeneOntologyMolecularFunctionprotein kinase binding

POTEE BIRC8 RASA1 ANKRA2 POTEF ACTB ACTG1 POTEKP POTEI CCNB1

4.89e-048736510GO:0019901
GeneOntologyMolecularFunctionnitrite reductase activity

XDH MTARC2

5.63e-0411652GO:0098809
GeneOntologyMolecularFunctionkinase binding

POTEE BIRC8 RASA1 ANKRA2 POTEF ACTB ACTG1 POTEKP POTEI CCNB1

1.09e-039696510GO:0019900
GeneOntologyMolecularFunctionoxidoreductase activity, acting on other nitrogenous compounds as donors

XDH MTARC2

1.37e-0317652GO:0016661
GeneOntologyMolecularFunctionstructural molecule activity

POTEE ANK3 POTEF ACTB ACTG1 MACF1 POTEKP POTEI NEXN

2.28e-03891659GO:0005198
GeneOntologyMolecularFunctioncysteine-type endopeptidase activity

BLMH SFRP1 SENP2

2.78e-0386653GO:0004197
GeneOntologyMolecularFunctioninward rectifier potassium channel activity

KCNJ5 KCNJ9

3.73e-0328652GO:0005242
GeneOntologyBiologicalProcesspostsynaptic actin cytoskeleton organization

POTEE POTEF ACTB ACTG1 POTEKP POTEI

5.35e-1031656GO:0098974
GeneOntologyBiologicalProcesspostsynaptic cytoskeleton organization

POTEE POTEF ACTB ACTG1 POTEKP POTEI

1.17e-0935656GO:0099188
GeneOntologyBiologicalProcessaxonogenesis

POTEE ANK3 POTEF ACTB ACTG1 MACF1 POTEKP POTEI NEXN ADCY1

1.03e-055666510GO:0007409
GeneOntologyBiologicalProcesscell morphogenesis involved in neuron differentiation

POTEE ANK3 POTEF ACTB ACTG1 MACF1 POTEKP POTEI CLRN1 NEXN ADCY1

1.99e-057486511GO:0048667
GeneOntologyBiologicalProcessaxon development

POTEE ANK3 POTEF ACTB ACTG1 MACF1 POTEKP POTEI NEXN ADCY1

3.04e-056426510GO:0061564
GeneOntologyBiologicalProcesspiRNA processing

TDRD7 MOV10L1 PIWIL4

4.41e-0522653GO:0034587
GeneOntologyBiologicalProcessregulation of transepithelial transport

ACTB ACTG1

5.84e-054652GO:0150111
GeneOntologyBiologicalProcessregulatory ncRNA processing

TDRD7 PUS10 MOV10L1 PIWIL4

8.76e-0574654GO:0070918
GeneOntologyBiologicalProcessregulation of cell-substrate adhesion

DOCK5 SFRP1 RASA1 ACTG1 MACF1 MEN1

1.48e-04254656GO:0010810
GeneOntologyBiologicalProcessneuron projection morphogenesis

POTEE ANK3 POTEF ACTB ACTG1 MACF1 POTEKP POTEI NEXN ADCY1

1.93e-048026510GO:0048812
GeneOntologyBiologicalProcessplasma membrane bounded cell projection morphogenesis

POTEE ANK3 POTEF ACTB ACTG1 MACF1 POTEKP POTEI NEXN ADCY1

2.28e-048196510GO:0120039
GeneOntologyBiologicalProcesscell projection morphogenesis

POTEE ANK3 POTEF ACTB ACTG1 MACF1 POTEKP POTEI NEXN ADCY1

2.44e-048266510GO:0048858
GeneOntologyBiologicalProcesscell morphogenesis

POTEE ANK3 RASA1 POTEF ACTB ACTG1 MACF1 POTEKP POTEI CLRN1 NEXN ADCY1

3.11e-0411946512GO:0000902
GeneOntologyCellularComponentNuA4 histone acetyltransferase complex

POTEE POTEF ACTB ACTG1 POTEKP POTEI

6.67e-1032666GO:0035267
GeneOntologyCellularComponentH4/H2A histone acetyltransferase complex

POTEE POTEF ACTB ACTG1 POTEKP POTEI

6.67e-1032666GO:0043189
GeneOntologyCellularComponentH4 histone acetyltransferase complex

POTEE POTEF ACTB ACTG1 POTEKP POTEI

5.81e-0945666GO:1902562
GeneOntologyCellularComponenthistone acetyltransferase complex

POTEE POTEF ACTB ACTG1 POTEKP POTEI

5.14e-0794666GO:0000123
GeneOntologyCellularComponentprotein acetyltransferase complex

POTEE POTEF ACTB ACTG1 POTEKP POTEI

9.35e-07104666GO:0031248
GeneOntologyCellularComponentacetyltransferase complex

POTEE POTEF ACTB ACTG1 POTEKP POTEI

1.23e-06109666GO:1902493
GeneOntologyCellularComponentactin filament

POTEE POTEF ACTB ACTG1 POTEKP POTEI

6.74e-06146666GO:0005884
GeneOntologyCellularComponentactin cytoskeleton

DOCK5 POTEE MPP4 POTEF ACTB ACTG1 MACF1 POTEKP POTEI NEXN

1.23e-055766610GO:0015629
GeneOntologyCellularComponentpole plasm

TDRD7 MOV10L1 PIWIL4

1.04e-0429663GO:0045495
GeneOntologyCellularComponentgerm plasm

TDRD7 MOV10L1 PIWIL4

1.04e-0429663GO:0060293
GeneOntologyCellularComponentP granule

TDRD7 MOV10L1 PIWIL4

1.04e-0429663GO:0043186
GeneOntologyCellularComponentdense body

ACTB ACTG1

2.04e-047662GO:0097433
GeneOntologyCellularComponenttransferase complex

RTF1 POTEE RANBP10 POTEF ACTB ACTG1 POTEKP POTEI CCNB1 MEN1

8.30e-049636610GO:1990234
GeneOntologyCellularComponentblood microparticle

POTEE POTEF ACTB ACTG1

1.12e-03144664GO:0072562
GeneOntologyCellularComponentpostsynaptic actin cytoskeleton

ACTB ACTG1

1.62e-0319662GO:0098871
GeneOntologyCellularComponentaxon

POTEE ANK3 MPP4 POTEF ACTB ACTG1 POTEKP POTEI NEXN

1.86e-03891669GO:0030424
GeneOntologyCellularComponentcostamere

ANK3 ACTG1

2.18e-0322662GO:0043034
GeneOntologyCellularComponentpostsynaptic cytoskeleton

ACTB ACTG1

3.04e-0326662GO:0099571
DomainActin_CS

POTEE POTEF ACTB ACTG1 POTEI

1.45e-0916625IPR004001
DomainACTINS_2

POTEE POTEF ACTB ACTG1 POTEI

2.05e-0917625PS00432
DomainActin/actin-like_CS

POTEE POTEF ACTB ACTG1 POTEI

2.83e-0918625IPR020902
DomainACTINS_ACT_LIKE

POTEE POTEF ACTB ACTG1 POTEI

3.84e-0919625PS01132
DomainActin

POTEE POTEF ACTB ACTG1 POTEI

5.44e-0831625IPR004000
DomainActin

POTEE POTEF ACTB ACTG1 POTEI

5.44e-0831625PF00022
DomainACTIN

POTEE POTEF ACTB ACTG1 POTEI

5.44e-0831625SM00268
DomainACTINS_1

ACTB ACTG1

3.00e-048622PS00406
DomainAnk_2

POTEE ANK3 ANKRA2 POTEF POTEI

7.33e-04215625PF12796
DomainSH3

DOCK5 RASA1 MPP4 ARHGAP10 MACF1

7.48e-04216625PS50002
DomainSH3_domain

DOCK5 RASA1 MPP4 ARHGAP10 MACF1

8.13e-04220625IPR001452
DomainAnk

POTEE ANK3 ANKRA2 POTEF POTEI

9.54e-04228625PF00023
DomainK_chnl_inward-rec_Kir_cyto

KCNJ5 KCNJ9

1.26e-0316622IPR013518
DomainIRK

KCNJ5 KCNJ9

1.26e-0316622PF01007
Domain-

KCNJ5 KCNJ9

1.26e-03166222.60.40.1400
DomainK_chnl_inward-rec_Kir

KCNJ5 KCNJ9

1.26e-0316622IPR016449
Domain-

POTEE ANK3 ANKRA2 POTEF POTEI

1.39e-032486251.25.40.20
DomainANK

POTEE ANK3 ANKRA2 POTEF POTEI

1.46e-03251625SM00248
DomainANK_REPEAT

POTEE ANK3 ANKRA2 POTEF POTEI

1.51e-03253625PS50088
DomainAnkyrin_rpt-contain_dom

POTEE ANK3 ANKRA2 POTEF POTEI

1.54e-03254625IPR020683
DomainANK_REP_REGION

POTEE ANK3 ANKRA2 POTEF POTEI

1.54e-03254625PS50297
DomainAnkyrin_rpt

POTEE ANK3 ANKRA2 POTEF POTEI

1.76e-03262625IPR002110
DomainSH3

DOCK5 RASA1 MPP4 ARHGAP10

5.75e-03216624SM00326
PathwayKEGG_MEDICUS_REFERENCE_ANXA2_S100A10_REGULATED_ACTIN_CYTOSKELETON

ACTB ACTG1

1.27e-045512M49034
PathwayREACTOME_RHO_GTPASES_ACTIVATE_IQGAPS

ACTB ACTG1 MEN1

1.53e-0429513MM15219
PathwayREACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS

ANK3 ACTB ACTG1

1.87e-0431513M877
PathwayREACTOME_RHO_GTPASES_ACTIVATE_IQGAPS

ACTB ACTG1 MEN1

2.05e-0432513M27491
PathwayWP_MOLYBDENUM_COFACTOR_MOCO_BIOSYNTHESIS

XDH MTARC2

2.66e-047512M39799
PathwayKEGG_MEDICUS_REFERENCE_ADRB3_UCP1_SIGNALING_PATHWAY

ACTB ACTG1 ADCY1

2.69e-0435513M47969
PathwayREACTOME_EPHB_MEDIATED_FORWARD_SIGNALING

RASA1 ACTB ACTG1

3.18e-0437513MM15022
PathwayREACTOME_MAP2K_AND_MAPK_ACTIVATION

ACTB ACTG1 IL17RD

3.72e-0439513MM15272
PathwayREACTOME_MAP2K_AND_MAPK_ACTIVATION

ACTB ACTG1 IL17RD

4.01e-0440513M27557
PathwayWP_COMMON_PATHWAYS_UNDERLYING_DRUG_ADDICTION

ACTB ACTG1 ADCY1

4.32e-0441513M39655
PathwayKEGG_MEDICUS_PATHOGEN_SHIGELLA_IPAB_C_D_TO_ITGA_B_TALIN_VINCULIN_SIGNALING_PATHWAY

ACTB ACTG1

4.55e-049512M47725
PathwayREACTOME_EPHB_MEDIATED_FORWARD_SIGNALING

RASA1 ACTB ACTG1

4.64e-0442513M27308
PathwayREACTOME_GABA_B_RECEPTOR_ACTIVATION

KCNJ5 KCNJ9 ADCY1

4.97e-0443513M954
PathwayREACTOME_GABA_B_RECEPTOR_ACTIVATION

KCNJ5 KCNJ9 ADCY1

5.32e-0444513MM15709
PathwayKEGG_MEDICUS_VARIANT_DELETED_DMD_TO_DYSTROPHIN_ASSOCIATED_PROTEIN_COMPLEX

ACTB ACTG1

5.67e-0410512M47575
PathwayREACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS

ACTB ACTG1

5.67e-0410512MM15112
PathwayREACTOME_GAP_JUNCTION_DEGRADATION

ACTB ACTG1

6.91e-0411512MM14732
PathwayREACTOME_GAP_JUNCTION_DEGRADATION

ACTB ACTG1

8.28e-0412512M15243
PathwayKEGG_MEDICUS_PATHOGEN_SHIGELLA_IPAC_TO_ACTIN_SIGNALING_PATHWAY

ACTB ACTG1

9.76e-0413512M47723
PathwayKEGG_MEDICUS_PATHOGEN_ESCHERICHIA_MAP_TO_CDC42_SIGNALING_PATHWAY

ACTB ACTG1

9.76e-0413512M47730
PathwayBIOCARTA_HIVNEF_PATHWAY

BIRC8 RASA1 ACTG1

1.08e-0356513MM1406
PathwayREACTOME_RHO_GTPASE_CYCLE

DOCK5 POTEE ARHGAP10 TEX2 ACTB ACTG1 COPS2

1.11e-03450517M27078
PathwayWP_NETWORK_MAP_OF_SARSCOV2_SIGNALING

ACTB ACTG1 SERPINA10 IL33 CCNB1

1.11e-03218515M42569
PathwayKEGG_MEDICUS_PATHOGEN_ESCHERICHIA_EAE_TIR_TCCP_TO_ACTIN_SIGNALING_PATHWAY

ACTB ACTG1

1.14e-0314512M47729
PathwayKEGG_MEDICUS_PATHOGEN_ESCHERICHIA_ESPT_TO_RAC_SIGNALING_PATHWAY

ACTB ACTG1

1.14e-0314512M47726
PathwayREACTOME_GABA_RECEPTOR_ACTIVATION

KCNJ5 KCNJ9 ADCY1

1.32e-0360513MM15708
PathwayREACTOME_GABA_RECEPTOR_ACTIVATION

KCNJ5 KCNJ9 ADCY1

1.32e-0360513M976
PathwayREACTOME_EPH_EPHRIN_SIGNALING

RASA1 ACTB ACTG1

1.66e-0365513MM14911
PathwayKEGG_MEDICUS_PATHOGEN_ESCHERICHIA_EAE_TIR_TO_ACTIN_SIGNALING_PATHWAY

ACTB ACTG1

1.69e-0317512M47728
PathwayREACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS

ACTB ACTG1

1.89e-0318512MM15123
PathwayREACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS

ACTB ACTG1

1.89e-0318512M840
PathwayBIOCARTA_MPR_PATHWAY

ADCY1 CCNB1

1.89e-0318512MM1407
Pubmed

Identification of a novel actin isoform in hepatocellular carcinoma.

POTEE POTEF ACTB ACTG1 POTEKP POTEI

1.83e-131566616824795
Pubmed

New interaction partners for Nek4.1 and Nek4.2 isoforms: from the DNA damage response to RNA splicing.

SLC25A3 DOCK5 POTEE NLRP14 POTEF ACTB ACTG1 PIWIL4 POTEKP

5.41e-0751366925798074
Pubmed

Duplication and extensive remodeling shaped POTE family genes encoding proteins containing ankyrin repeat and coiled coil domains.

POTEE POTEKP POTEI

5.44e-07966316364570
Pubmed

Unbiased Identification of trans Regulators of ADAR and A-to-I RNA Editing.

POTEE PRPF3 POTEF ACTB ACTG1 POTEKP POTEI

8.49e-0727166732433965
Pubmed

Shotgun proteomics reveals specific modulated protein patterns in tears of patients with primary open angle glaucoma naïve to therapy.

POTEE POTEF ACTB ACTG1 POTEI

1.13e-069666523580065
Pubmed

The interaction between ubiquitin C-terminal hydrolase 37 and glucose-regulated protein 78 in hepatocellular carcinoma.

POTEE POTEF ACTB ACTG1 POTEKP

1.38e-0610066521800051
Pubmed

RSPO-LGR4 functions via IQGAP1 to potentiate Wnt signaling.

SLC25A3 POTEF ACTB ACTG1 POTEKP NEXN

2.42e-0620266624639526
Pubmed

SRF phosphorylation by glycogen synthase kinase-3 promotes axon growth in hippocampal neurons.

ACTB ACTG1 NEXN

2.92e-061566324623780
Pubmed

Beta and gamma-cytoplasmic actins display distinct distribution and functional diversity.

ACTB ACTG1

3.55e-06266219638415
Pubmed

Beta- and gamma-cytoplasmic actins are required for meiosis in mouse oocytes.

ACTB ACTG1

3.55e-06266221778137
Pubmed

De novo mutations in the actin genes ACTB and ACTG1 cause Baraitser-Winter syndrome.

ACTB ACTG1

3.55e-06266222366783
Pubmed

Botulinum C2 toxin ADP-ribosylates cytoplasmic beta/gamma-actin in arginine 177.

ACTB ACTG1

3.55e-0626623335520
Pubmed

Association of human immunodeficiency virus Nef protein with actin is myristoylation dependent and influences its subcellular localization.

ACTB ACTG1

3.55e-0626629288906
Pubmed

High level expression of transfected beta- and gamma-actin genes differentially impacts on myoblast cytoarchitecture.

ACTB ACTG1

3.55e-0626621577857
Pubmed

Prenatal presentation and diagnosis of Baraitser-Winter syndrome using exome sequencing.

ACTB ACTG1

3.55e-06266232588558
Pubmed

Baraitser-Winter cerebrofrontofacial syndrome.

ACTB ACTG1

3.55e-06266227625340
Pubmed

Baraitser-Winter Cerebrofrontofacial Syndrome

ACTB ACTG1

3.55e-06266226583190
Pubmed

Knockout of ACTB and ACTG1 with CRISPR/Cas9(D10A) Technique Shows that Non-Muscle β and γ Actin Are Not Equal in Relation to Human Melanoma Cells' Motility and Focal Adhesion Formation.

ACTB ACTG1

3.55e-06266232326615
Pubmed

Severe forms of Baraitser-Winter syndrome are caused by ACTB mutations rather than ACTG1 mutations.

ACTB ACTG1

3.55e-06266223756437
Pubmed

A primate-specific POTE-actin fusion protein plays a role in apoptosis.

POTEE POTEF

3.55e-06266219669888
Pubmed

Cytochalasin D-induced actin gene expression in murine erythroleukemia cells.

ACTB ACTG1

3.55e-0626628482333
Pubmed

Isolation of cDNA clones for mouse cytoskeletal gamma-actin and differential expression of cytoskeletal actin mRNAs in mouse cells.

ACTB ACTG1

3.55e-0626623221869
Pubmed

Impaired muscle relaxation and mitochondrial fission associated with genetic ablation of cytoplasmic actin isoforms.

ACTB ACTG1

3.55e-06266229265728
Pubmed

Multi-isotope imaging mass spectrometry reveals slow protein turnover in hair-cell stereocilia.

ACTB ACTG1

3.55e-06266222246323
Pubmed

Structure, chromosome location, and expression of the human gamma-actin gene: differential evolution, location, and expression of the cytoskeletal beta- and gamma-actin genes.

ACTB ACTG1

3.55e-0626622837653
Pubmed

Astrocytic cAMP modulates memory via synaptic plasticity.

ACTB ADCY1

3.55e-06266233452135
Pubmed

Prevalence of Cytoplasmic Actin Mutations in Diffuse Large B-Cell Lymphoma and Multiple Myeloma: A Functional Assessment Based on Actin Three-Dimensional Structures.

ACTB ACTG1

3.55e-06266232349449
Pubmed

Conditional inactivation of Miwi2 reveals that MIWI2 is only essential for prospermatogonial development in mice.

MOV10L1 PIWIL4

3.55e-06266224464225
Pubmed

Baraitser-Winter cerebrofrontofacial syndrome: Report of two adult siblings.

ACTB ACTG1

3.55e-06266232506774
Pubmed

Differential arginylation of actin isoforms is regulated by coding sequence-dependent degradation.

ACTB ACTG1

3.55e-06266220847274
Pubmed

Measurements of spatiotemporal changes in G-actin concentration reveal its effect on stimulus-induced actin assembly and lamellipodium extension.

ACTB ACTG1

3.55e-06266221502360
Pubmed

The evolution and complexity of the genes encoding the cytoskeletal proteins of human epidermal cells.

ACTB ACTG1

3.55e-0626626686106
Pubmed

Actin amino-acid sequences. Comparison of actins from calf thymus, bovine brain, and SV40-transformed mouse 3T3 cells with rabbit skeletal muscle actin.

ACTB ACTG1

3.55e-062662213279
Pubmed

The First Korean Case of Baraitser-Winter Cerebro-Fronto-Facial Syndrome with a Novel Mutation in ACTB Diagnosed Via Targeted Gene Panel Sequencing and Literature Review.

ACTB ACTG1

3.55e-06266233334799
Pubmed

β-Actin specifically controls cell growth, migration, and the G-actin pool.

ACTB ACTG1

3.55e-06266221900491
Pubmed

Perturbation of the mutated EGFR interactome identifies vulnerabilities and resistance mechanisms.

SLC25A3 POTEE POTEF ACTB ACTG1 POTEKP

9.42e-0625666624189400
Pubmed

The HIV-1 Tat protein recruits a ubiquitin ligase to reorganize the 7SK snRNP for transcriptional activation.

SLC25A3 POTEE MCMBP PRPF3 POTEF ACTB ACTG1 MACF1 POTEKP POTEI MPG

1.02e-051153661129845934
Pubmed

Molecular characterization of abLIM, a novel actin-binding and double zinc finger protein.

ACTB ACTG1

1.06e-0536629245787
Pubmed

Impact of altered actin gene expression on vinculin, talin, cell spreading, and motility.

ACTB ACTG1

1.06e-0536627646816
Pubmed

Molecular basis for G-actin binding to RPEL motifs from the serum response factor coactivator MAL.

ACTB ACTG1

1.06e-05366219008859
Pubmed

Angiostatin and plasminogen share binding to endothelial cell surface actin.

ACTB ACTG1

1.06e-05366215746964
Pubmed

Interaction of Receptor-Binding Domain of the SARS-CoV-2 Omicron Variant with hACE2 and Actin.

ACTB ACTG1

1.06e-05366239195208
Pubmed

Mutations in the MOV10L1 ATP Hydrolysis Motif Cause piRNA Biogenesis Failure and Male Sterility in Mice.

MOV10L1 PIWIL4

1.06e-05366227655786
Pubmed

Actin Is Crucial for All Kinetically Distinguishable Forms of Endocytosis at Synapses.

ACTB ACTG1

1.06e-05366227840001
Pubmed

Restricted morphological and behavioral abnormalities following ablation of β-actin in the brain.

ACTB ACTG1

1.06e-05366222403730
Pubmed

Functional molecular complexes of human N-formyl chemoattractant receptors and actin.

ACTB ACTG1

1.06e-0536628228254
Pubmed

Hyperalgesia and blunted morphine analgesia in G protein-gated potassium channel subunit knockout mice.

KCNJ5 KCNJ9

1.06e-05366212499858
Pubmed

CTGF/Hcs24 interacts with the cytoskeletal protein actin in chondrocytes.

ACTB ACTG1

1.06e-05366212470643
Pubmed

Evolution and expression of chimeric POTE-actin genes in the human genome.

POTEE POTEF

1.06e-05366217101985
Pubmed

Isolation and characterization of full-length cDNA clones for human alpha-, beta-, and gamma-actin mRNAs: skeletal but not cytoplasmic actins have an amino-terminal cysteine that is subsequently removed.

ACTB ACTG1

1.06e-0536626865942
Pubmed

Identification of GIRK2-4 subunits in human esophageal smooth muscle cells.

KCNJ5 KCNJ9

1.06e-05366221637918
Pubmed

Mutation analysis of the short cytoplasmic domain of the cell-cell adhesion molecule CEACAM1 identifies residues that orchestrate actin binding and lumen formation.

ACTB ACTG1

1.06e-05366217192268
Pubmed

L1 endocytosis is controlled by a phosphorylation-dephosphorylation cycle stimulated by outside-in signaling by L1.

ACTB ACTG1

2.12e-05466212082080
Pubmed

β-actin and γ-actin are each dispensable for auditory hair cell development but required for Stereocilia maintenance.

ACTB ACTG1

2.12e-05466220976199
Pubmed

Structural characterization of the mouse Girk genes.

KCNJ5 KCNJ9

2.12e-05466211891065
Pubmed

Co-expression of human Kir3 subunits can yield channels with different functional properties.

KCNJ5 KCNJ9

2.12e-05466210659995
Pubmed

Functional analyses of placental protein 13/galectin-13.

ACTB ACTG1

2.12e-05466215009185
Pubmed

The formin-homology-domain-containing protein FHOD1 enhances cell migration.

ACTB ACTG1

2.12e-05466212665555
Pubmed

Expression of G-protein inwardly rectifying potassium channels (GIRKs) in lung cancer cell lines.

KCNJ5 KCNJ9

2.12e-05466216109170
Pubmed

Molecular cloning and functional characterization of mouse coactosin-like protein.

ACTB ACTG1

2.12e-05466211785969
Pubmed

IQGAP1 regulates reactive oxygen species-dependent endothelial cell migration through interacting with Nox2.

ACTB ACTG1

2.12e-05466216179592
Pubmed

Number and evolutionary conservation of alpha- and beta-tubulin and cytoplasmic beta- and gamma-actin genes using specific cloned cDNA probes.

ACTB ACTG1

2.12e-0546626893015
Pubmed

Mouse MOV10L1 associates with Piwi proteins and is an essential component of the Piwi-interacting RNA (piRNA) pathway.

MOV10L1 PIWIL4

2.12e-05466220534472
Pubmed

Cell type-specific subunit composition of G protein-gated potassium channels in the cerebellum.

KCNJ5 KCNJ9

2.12e-05466218088366
Pubmed

The proline-rich domain of tau plays a role in interactions with actin.

ACTB ACTG1

2.12e-05466219895707
Pubmed

Molecular properties of neuronal G-protein-activated inwardly rectifying K+ channels.

KCNJ5 KCNJ9

2.12e-0546627499385
Pubmed

Functional analysis of the weaver mutant GIRK2 K+ channel and rescue of weaver granule cells.

KCNJ5 KCNJ9

2.12e-0546628630252
Pubmed

The complex of TRIP-Br1 and XIAP ubiquitinates and degrades multiple adenylyl cyclase isoforms.

BIRC8 ADCY1

2.12e-05466228656888
Pubmed

A novel nuclear complex of DRR1, F-actin and COMMD1 involved in NF-κB degradation and cell growth suppression in neuroblastoma.

BIRC8 ACTB NEXN

2.30e-052966328604741
Pubmed

HIV-1 Gag-RNA interaction occurs at a perinuclear/centrosomal site; analysis by confocal microscopy and FRET.

ACTB ACTG1

3.53e-05566216101678
Pubmed

Microtubule associated protein MAP1A is an actin-binding and crosslinking protein.

ACTB ACTG1

3.53e-0556627820861
Pubmed

Monitoring of S protein maturation in the endoplasmic reticulum by calnexin is important for the infectivity of severe acute respiratory syndrome coronavirus.

ACTB ACTG1

3.53e-05566222915798
Pubmed

Nonredundant roles of cytoplasmic β- and γ-actin isoforms in regulation of epithelial apical junctions.

ACTB ACTG1

3.53e-05566222855531
Pubmed

Subcellular compartment-specific molecular diversity of pre- and post-synaptic GABA-activated GIRK channels in Purkinje cells.

KCNJ5 KCNJ9

3.53e-05566219558451
Pubmed

Cloning provides evidence for a family of inward rectifier and G-protein coupled K+ channels in the brain.

KCNJ5 KCNJ9

3.53e-0556627926018
Pubmed

Virus assembly and plasma membrane domains: which came first?

ACTB ACTG1

5.29e-05666222989508
Pubmed

HIV-1 protease cleaves actin during acute infection of human T-lymphocytes.

ACTB ACTG1

5.29e-0566621540415
Pubmed

Mammalian CAP interacts with CAP, CAP2, and actin.

ACTB ACTG1

5.29e-0566628761950
Pubmed

HIV type 1 Gag and nucleocapsid proteins: cytoskeletal localization and effects on cell motility.

ACTB ACTG1

5.29e-05666211709093
Pubmed

Actin associates with the nucleocapsid domain of the human immunodeficiency virus Gag polyprotein.

ACTB ACTG1

5.29e-0566629971772
Pubmed

Tagging the human immunodeficiency virus gag protein with green fluorescent protein. Minimal evidence for colocalisation with actin.

ACTB ACTG1

5.29e-05666210049817
Pubmed

Human immunodeficiency virus nucleocapsid protein polymorphisms modulate the infectivity of RNA packaging mutants.

ACTB ACTG1

5.29e-05666212009869
Pubmed

FISH localization of human cytoplasmic actin genes ACTB to 7p22 and ACTG1 to 17q25 and characterization of related pseudogenes.

ACTB ACTG1

5.29e-0566628941379
Pubmed

The inward rectifier potassium channel family.

KCNJ5 KCNJ9

5.29e-0566627580148
Pubmed

Rapid, redox-mediated mechanical susceptibility of the cortical microtubule lattice in skeletal muscle.

ACTB ACTG1

5.29e-05666233002761
Pubmed

HIV-1 Tat protein variants: critical role for the cysteine region in synaptodendritic injury.

ACTB ACTG1

5.29e-05666223811015
Pubmed

A role for Fkbp6 and the chaperone machinery in piRNA amplification and transposon silencing.

MOV10L1 PIWIL4

5.29e-05666222902560
Pubmed

Retroviral assembly and budding occur through an actin-driven mechanism.

ACTB ACTG1

5.29e-05666219883584
Pubmed

Dynamic imaging of cell-free and cell-associated viral capture in mature dendritic cells.

ACTB ACTG1

5.29e-05666221917091
Pubmed

HIV-1 Gag protein associates with F-actin present in microfilaments.

ACTB ACTG1

5.29e-0566628661406
Pubmed

A protein ballet around the viral genome orchestrated by HIV-1 reverse transcriptase leads to an architectural switch: from nucleocapsid-condensed RNA to Vpr-bridged DNA.

ACTB ACTG1

5.29e-05666223017337
Pubmed

Interaction of the human immunodeficiency virus type 1 nucleocapsid with actin.

ACTB ACTG1

5.29e-05666210074138
Pubmed

Migfilin and Mig-2 link focal adhesions to filamin and the actin cytoskeleton and function in cell shape modulation.

ACTB ACTG1

5.29e-05666212679033
Pubmed

Synaptodendritic recovery following HIV Tat exposure: neurorestoration by phytoestrogens.

ACTB ACTG1

5.29e-05666223875777
Pubmed

Establishment of a functional human immunodeficiency virus type 1 (HIV-1) reverse transcription complex involves the cytoskeleton.

ACTB ACTG1

5.29e-0566629841925
Pubmed

Optimized fragmentation schemes and data analysis strategies for proteome-wide cross-link identification.

POTEF ACTB MACF1 POTEKP SLFN5 COPS2 NEXN

7.22e-0553866728524877
Pubmed

A review and comparison of the murine alpha1-antitrypsin and alpha1-antichymotrypsin multigene clusters with the human clade A serpins.

SERPINA10 ADCY1

7.40e-05766212659817
Pubmed

HIV-1 replication from after cell entry to the nuclear periphery.

ACTB ACTG1

7.40e-05766217504171
Pubmed

The PDZ-adaptor protein syntenin-1 regulates HIV-1 entry.

ACTB ACTG1

7.40e-05766222535526
Pubmed

siRNA and pharmacological inhibition of endocytic pathways to characterize the differential role of macropinocytosis and the actin cytoskeleton on cellular uptake of dextran and cationic cell penetrating peptides octaarginine (R8) and HIV-Tat.

ACTB ACTG1

7.40e-05766222465675
InteractionACTG2 interactions

POTEE POTEF ACTB ACTG1 POTEI

4.72e-0749645int:ACTG2
InteractionGSN interactions

POTEF ACTB ACTG1 POTEI NEXN MEN1 MPG

4.82e-06212647int:GSN
InteractionPOTEJ interactions

POTEE ACTB ACTG1 POTEI

2.23e-0552644int:POTEJ
InteractionERRFI1 interactions

POTEE POTEF ACTB ACTG1 POTEKP

2.28e-05107645int:ERRFI1
InteractionSCIN interactions

POTEF ACTB ACTG1 POTEI

3.45e-0558644int:SCIN
InteractionGC interactions

POTEF ACTB POTEKP POTEI

4.49e-0562644int:GC
InteractionCAP2 interactions

POTEF ACTB ACTG1 POTEI

5.75e-0566644int:CAP2
InteractionNEK4 interactions

SLC25A3 DOCK5 POTEE NLRP14 POTEF ACTB ACTG1 PIWIL4 POTEKP

8.78e-05582649int:NEK4
InteractionPHACTR2 interactions

ACTB ACTG1 POTEI

1.05e-0429643int:PHACTR2
InteractionCOBL interactions

ACTB ACTG1 POTEKP MEN1

1.11e-0478644int:COBL
Cytoband2q21.1

POTEE POTEF POTEKP POTEI

1.56e-06586642q21.1
CytobandEnsembl 112 genes in cytogenetic band chr2q21

POTEE POTEF POTEKP POTEI

6.92e-05151664chr2q21
GeneFamilyAnkyrin repeat domain containing|POTE ankyrin domain containing

POTEE POTEF POTEKP POTEI

1.77e-0813424685
GeneFamilyActins

ACTB ACTG1

7.86e-056422929
GeneFamilyAnkyrin repeat domain containing

POTEE ANK3 ANKRA2 POTEF POTEI

2.34e-04242425403
GeneFamilyPotassium voltage-gated channel subfamily J

KCNJ5 KCNJ9

6.19e-0416422276
CoexpressionAtlasdev gonad_e13.5_M_GermCell_Oct_top-relative-expression-ranked_1000

TDRD7 TBC1D32 THNSL1 PRPF3 TEX2 MOV10L1 FMR1NB PLEKHA1 PIWIL4 IL17RD CCNB1

2.00e-058106211gudmap_dev gonad_e13.5_M_GermCell_Oct_1000
ToppCell5'-Adult-LargeIntestine-Epithelial-neuro-epithelial-EC_cells_(TAC1+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

POTEE SERPINA10 POTEI ADCY1 MCOLN3

5.75e-06175655182e45f5c02214d6b9f317ff5dc43af8b42de978
ToppCellSmart-seq2-blood_(Smart-seq2)-hematologic-thrombocytic|blood_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

POTEE POTEF ACTB POTEI NEXN

6.59e-06180655fb3d549c2a69b2157a486786ddd775ca16699ed0
ToppCellSmart-seq2-blood_(Smart-seq2)-hematologic-thrombocytic-platelet|blood_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

POTEE POTEF ACTB POTEI NEXN

6.59e-06180655beb4d777e0c5fa0a59672dbc3dbb7732498605ff
ToppCelldroplet-Heart-4Chambers-21m-Mesenchymal-cardiomyocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ANK3 KCNJ5 MOV10L1 NEXN ADCY1

8.79e-06191655c172c9e17b893b290e4aa8af5e5e4cd3e4818372
ToppCelldroplet-Heart-4Chambers-21m-Mesenchymal-atrial_cardiomyocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ANK3 KCNJ5 MOV10L1 NEXN ADCY1

8.79e-06191655715f5b449b8e075959c05a5b38389df319663164
ToppCellP15-Epithelial-epithelial_progenitor_cell|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

SFRP1 ANK3 SLCO4C1 IL33

7.22e-0515265400d5503d462cfa009fb4cac79ecee11725a18b9a
ToppCell10x3'2.3-week_12-13-Myeloid_DC-DC-DC3|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

SLC25A3 ACTB ACTG1 CCNB1

9.02e-0516165439030380e04f57f8e7de231577ec3177e1b6490d
ToppCellfacs-Mammary_Gland-Mammary_Gland-18m-Epithelial-nan|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MOV10L1 ACTB HMGCS2 IL33

9.02e-05161654b9a63fc9becc44d305fc7c221283bf59ec06b10f
ToppCell10x5'-blood-Lymphocytic_T_CD4-T_CD4/CD8|blood / Manually curated celltypes from each tissue

ANK3 RASA1 CELF2 MACF1

9.24e-05162654b4535bcb3f469bc139e73f1122f4070013e5a1de
ToppCellTCGA-Brain-Primary_Tumor-Glioblastoma-Primary_GBM-11|TCGA-Brain / Sample_Type by Project: Shred V9

POTEE POTEF POTEI

1.07e-0463653d7dc1356a60cb527fe668328d5375f352239d911
ToppCellfacs-Heart-Unknown-3m-Mesenchymal-atrial_myocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KCNJ5 MOV10L1 NEXN ADCY1

1.16e-04172654ee8ce9e8c9a6d3ee2be113f77743958005f4b3f0
ToppCellfacs-Heart-Unknown-3m-Mesenchymal-atrial_cardiomyocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KCNJ5 MOV10L1 NEXN ADCY1

1.16e-04172654bd468a7ea6ec832dcf6a816a1e0c03fa0f176dad
ToppCellP07-Epithelial|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

ANK3 SLCO4C1 HMGCS2 IL33

1.19e-041736548b10087a917b825809d35a2b2b349c73a2782472
ToppCellP28-Epithelial-alveolar_epithelial_cell-type_II_pneumocyte|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

ANK3 SLCO4C1 PIWIL4 IL33

1.24e-041756548a4ed775ff973123dbcfe9c809959d11a62450c9
ToppCell3'-GW_trimst-1-LargeIntestine-Mesenchymal-myocytic-SMC_(PART1/CAPN3+)|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SFRP1 ANK3 ACTG1 NEXN

1.33e-041786540fb36679cddc9ed8f4b5b34e174d5133c2ea1c76
ToppCell3'-GW_trimst-1.5-SmallIntestine-Epithelial-epithelial_progenitor_cell-TA|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

XDH HMGCS2 MCOLN3 CCNB1

1.48e-041836540d21befacefc6c597e7b501ed41b7fe9385a78df
ToppCellControl-Myeloid-MoAM3,_VCAN|Myeloid / Condition, Lineage and Cell class

SLCO4C1 ACTB ACTG1 MCOLN3

1.57e-041866540bf16ac48931b62bb3c33d63ff4279654148e293
ToppCelldroplet-Limb_Muscle-MUSCLE-30m-Macroglial-nan|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SFRP1 ANK3 PIWIL4 HMGCS2

1.60e-0418765416e55d802fc4e71878305e61ad03806aabd59537
ToppCell-Unknown-Endothelial-Myofibroblast| / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

TDRD7 ANK3 CELF2 SENP2

1.64e-041886546468fa95ad0395395301115286f2d8c0df5d3882
ToppCell-Unknown-Endothelial| / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

TDRD7 ANK3 CELF2 SENP2

1.64e-041886547a81ac5c79c3eb26639b52d2b9fd5e7ef9798fd6
ToppCellT_cells-ISG-high_CD4+_T_cells|World / Immune cells in Kidney/Urine in Lupus Nephritis

TDRD7 ANK3 SLFN5 NEXN

1.64e-041886546f8946d4710f6e32c937213f99b790b098b8819c
ToppCellLA-13._Vascular_Smooth_Muscle|LA / Chamber and Cluster_Paper

ARHGAP10 MACF1 CHSY3 NEXN

1.64e-0418865434e1b074a3995aa46ab194eb45115d76d1a5514d
ToppCell-Unknown| / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

TDRD7 ANK3 CELF2 SENP2

1.64e-041886549cb718bfe1358c6fd842f096e228eb0abb9aefc6
ToppCellfacs-Heart-LA/RA-3m|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ANK3 KCNJ5 MOV10L1 ADCY1

1.67e-04189654a08b2d0fa35ffa510050ecffdc68e1b79bbe1632
ToppCellrenal_cortex_nuclei-Adult_normal_reference|renal_cortex_nuclei / Celltypes from Cells and Nuclei per compartment and clinical group

ANK3 CELF2 ARHGAP10 HMGCS2

1.67e-04189654a48df46274d51e84ffb40264646de7346104efb9
ToppCellfacs-Heart-LA/RA|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ANK3 KCNJ5 MOV10L1 ADCY1

1.67e-04189654efa913d9c16fc32166b484d92b6449e8a0c59e03
ToppCellwk_08-11-Epithelial-Proximal_epithelial-GHRL+_neuroendocrine|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

SERPINA10 POTEI ADCY1 MCOLN3

1.71e-04190654b5c6f3248c0c2f648e1578457c6a729ca22bf0da
ToppCellE18.5-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT2|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ANK3 SLCO4C1 PIWIL4 IL33

1.74e-0419165408b1d3b3be78bf7fd9e9039027e35275f2be88d0
ToppCellE16.5-samps-Mesenchymal-Matrix_fibroblast-_fetal|E16.5-samps / Age Group, Lineage, Cell class and subclass

CELF2 XDH MACF1 NEXN

1.74e-041916543379d145d34f89150f7b06d1340022cfc6b4a6ce
ToppCellE18.5-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT2-AT2_mature|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ANK3 SLCO4C1 PIWIL4 IL33

1.74e-04191654f896fb490c4a17adac5e00ed9b6e6145eab1e564
ToppCellControl-Myeloid-MoAM3,_VCAN|Control / Condition, Lineage and Cell class

SLCO4C1 ACTB ACTG1 MCOLN3

1.74e-0419165476c2fbc62855a65600cd6b8dd1e2d2c3d7415921
ToppCellhuman_hepatoblastoma-Hepatic_Stellate_cells|human_hepatoblastoma / Sample and Cell Type and Tumor Cluster (all cells)

ANK3 ARHGAP10 NEXN IL33

1.74e-0419165478c3c2fdb68c3407f2436f90e1e6a780bbf8b79e
ToppCellPND07|World / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CELF2 ACTB MACF1 NEXN

1.78e-041926548171a60df481195c39a7f740effcae8e4deb6ca7
ToppCelldroplet-Heart-nan-24m-Mesenchymal-fibroblast_of_cardiac_tissue|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SFRP1 CELF2 HMGCS2 IL33

1.81e-041936540ca0439dfdcb2361ca8d1015fb874a5b5c635d31
ToppCellTCGA-Endometrium-Primary_Tumor-Endometrial_Adenocarcinoma-Endometrioid-1|TCGA-Endometrium / Sample_Type by Project: Shred V9

RTF1 MCMBP PLEKHA1 IL17RD

1.81e-04193654c2673d86f7d7b849788036032a93a6d136a70040
ToppCelldroplet-Heart-nan-24m-Mesenchymal-fibroblast|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SFRP1 CELF2 HMGCS2 IL33

1.81e-04193654d08919db9601941569b9a143dad4d8e6f56a4389
ToppCellpdx-Tumor_cells-T7|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)

SLC25A3 ROMO1 ACTB ACTG1

1.85e-04194654ddcc8f91459afcb9d52a4efb64d9fac4e4f38c7f
ToppCellE15.5-Mesenchymal-mesenchymal_fibroblast-mesenchymal_progenitor_cell|E15.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

SFRP1 CELF2 MACF1 NEXN

1.85e-04194654f2f7b9aad7588c8020a4850ff9333e1db8eafac7
ToppCellE17.5-Mesenchymal-mesenchymal_fibroblast-mesenchymal_progenitor_cell|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

SFRP1 CELF2 MACF1 NEXN

1.92e-04196654028a06ed92f1c058dcbeacd335625bf529e87a7b
ToppCellE18.5-Mesenchymal-Mesenchymal_structural|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SFRP1 CELF2 MACF1 NEXN

1.92e-0419665497e26622d9582b092c18ff5b7e957818f99d9631
ToppCellE18.5-Mesenchymal-Mesenchymal_structural-Fibroblastic|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SFRP1 CELF2 MACF1 NEXN

1.92e-04196654f429f045ba45e24717963315832150b12a115bfa
ToppCelldroplet-Heart-HEART-1m-Mesenchymal-cardiomyocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KCNJ5 MOV10L1 NEXN ADCY1

1.92e-04196654a582130862bee76c0385156a333bfdfc75cf218b
ToppCelldroplet-Heart-HEART-1m-Mesenchymal-atrial_cardiomyocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KCNJ5 MOV10L1 NEXN ADCY1

1.92e-04196654fba52a4b82086dbae9a55038bf44c4539be926f5
ToppCellSmart-start-Cell-Wel_seq-Neoplastic-Differentiated-like-AC-like-AC-like_Prolif-E|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

ROMO1 COX16 CLRN1 CCNB1

1.96e-0419765441bdea47b9b1f6415a866a515d1535ea942fdede
ToppCell5'-GW_trimst-1.5-LargeIntestine-Mesenchymal-immature_mesenchymal_cell-Mesoderm_1_(HAND1+)|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SFRP1 ANK3 ACTB ACTG1

1.96e-041976542a90422ba400b951517603a916f34221056d0f3d
ToppCellPND01-Mesenchymal|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SFRP1 CELF2 MACF1 NEXN

1.96e-04197654292b8cc3dafddf5d323fe4e3d3ea5ac61e6ce027
ToppCell5'-GW_trimst-1.5-LargeIntestine|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SFRP1 CELF2 ACTB ACTG1

1.96e-041976540b2ad6a933ff1a325649cc8f139380fd158a1d42
ToppCell5'-GW_trimst-1.5-LargeIntestine-Mesenchymal|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SFRP1 CELF2 ACTB ACTG1

1.96e-041976545f6fce382f273e789ffbb75b63e9b4e87519918e
ToppCellBronchial-NucSeq-Stromal-Peri/Epineurial_-NAF_endoneurial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

ROMO1 ARHGAP10 IL17RD ADCY1

1.96e-041976546806ec223e542f0475303698eb78c1cc527f5c6b
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Degenerative_Medullary_Thick_Ascending_Limb_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SLC25A3 SFRP1 ACTB ACTG1

1.96e-0419765402cc9d39afefa5e5b6f5d93f9adc3a20050b70dd
ToppCellSevere-CD8+_T_activated|Severe / Disease group and Cell class

DOCK5 ACTB ACTG1 SLFN5

1.96e-04197654bb1e3e1d841c2c7141eb1099e7755860b168b6fc
ToppCell10x5'v1-week_12-13|World / cell types per 3 fetal stages;per 3',per 5'

ROMO1 COX16 ACTB ACTG1

1.96e-041976544b107359f2d703a1d0348932a6b64eb447d30b3d
ToppCell(08)_Brush+PNEC-(0)_Reference|(08)_Brush+PNEC / shred by cell type by condition

SLC25A3 ROMO1 POTEF ACTB

1.96e-04197654d500bfed2a76f7300f2f17b60962c18a40efd084
ToppCellE16.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-PMP|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SFRP1 CELF2 NEXN CCNB1

2.00e-04198654148f5fee19ea8dff7f2de4ca69c3b03e5221985d
ToppCell10x_3'_v3-thymus_(10x_3'_v3)-lymphocytic-T_lymphocytic-CD4-positive_helper_T_cell|thymus_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

ANK3 CELF2 ACTG1 SLFN5

2.00e-04198654c4d8d133e571ad3a7c5de93aa7befb67cb7a003d
ToppCellSevere-CD8+_T_activated|World / Disease group and Cell class

DOCK5 ACTB ACTG1 SLFN5

2.00e-041986545ff98c9b6c8c6863767b76c7745f263568f86acc
ToppCell10x_3'_v3-thymus_(10x_3'_v3)-lymphocytic-T_lymphocytic|thymus_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

CELF2 ACTB ACTG1 SLFN5

2.00e-04198654db107a5511571384f26e26c6301aef9a9f2423c4
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Degenerative_Medullary_Thick_Ascending_Limb_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SLC25A3 SFRP1 ACTB ACTG1

2.00e-041986540de0c612a1f030debde28bfd6fbae3697e8b48de
ToppCellMultiple_Sclerosis|World / Disease, Lineage and Cell Type

SLC25A3 ACTB ACTG1 SLFN5

2.00e-0419865446728bb03f4b0d30ae9b62d984a6c2d00cfd370a
ToppCellbackground-Hepatic_Stellate_cells|background / Sample and Cell Type and Tumor Cluster (all cells)

ANK3 ARHGAP10 CHSY3 NEXN

2.00e-04198654bd11b0e9e80449aab979a02c1023e0638c431c7c
ToppCellCOVID-19_Moderate-NK|World / disease group, cell group and cell class

SFRP1 SLCO4C1 PLEKHA1 SLFN5

2.04e-04199654c41b67b760831c7d5e19fabcc932a056dc560f93
ToppCell(02)_MMP9/10+-(2)_GFP_FOXI1|(02)_MMP9/10+ / shred by cell type by condition

RTF1 PLEKHA1 SLFN5 NEXN

2.04e-0419965418a7f9ced4364f45b184bd529f32ef02c27779d3
ToppCellVE-CD4-exh_CD4|VE / Condition, Cell_class and T cell subcluster

ACTB ACTG1 MACF1 SLFN5

2.04e-041996546b00a393ad06ae91bf135a54a53ad4de68956193
ToppCelllymphoid-T_cell-CD8+_Naive_T_cell|lymphoid / Lineage, cell class and subclass

SLC25A3 ACTB ACTG1 SLFN5

2.04e-0419965422926327c93ede9f3408c99a0d56e373a33240ef
ToppCellFetal_brain-fetalBrain_Zhong_nature-GW09-Neuronal|GW09 / Sample Type, Dataset, Time_group, and Cell type.

ANK3 CELF2 ACTB ACTG1

2.08e-04200654e9eb348a66011d8aace4331f84690ae27cb0d061
ToppCellcellseq2-Epithelial-Epithelial_Glandular-MEC|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

SFRP1 ACTB ACTG1 NEXN

2.08e-0420065453160551d558148d1d80ec87b90dd6be7d36e4c7
ToppCell5'-GW_trimst-1-SmallIntestine-Mesenchymal-immature_mesenchymal_cell|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SLC25A3 SFRP1 ACTB ACTG1

2.08e-042006544234bdc70a9941d4bf77148d75bd271e0c114b88
ToppCellcellseq2-Epithelial-Epithelial_Glandular-MEC-MEC|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

SFRP1 ACTB ACTG1 NEXN

2.08e-04200654af4d922659b6f9d446797f7a3922a211e22f88e4
ToppCellCOVID-19-COVID-19_Severe-Myeloid-immature_Neutrophil|COVID-19_Severe / Disease, condition lineage and cell class

ROMO1 SLCO4C1 ACTB PIWIL4

2.08e-04200654cbe667eda1af222467df8bfa157aa22df488f133
ToppCellParenchymal-10x3prime_v2-Endothelial-Endothelia_vascular-VE_systemic_arterial|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

THNSL1 MOV10L1 IL17RD IL33

2.08e-04200654a8b59e6fe04271fef61db911a286b5c48438bb84
ToppCellNeuronal|World / cells hierarchy compared to all cells using T-Statistic

RTF1 ANK3 CELF2 CHSY3

2.08e-0420065448d801219bc771d6c7e151dc88ca4c179988de85
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Degenerative_Medullary_Thick_Ascending_Limb_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

SLC25A3 SFRP1 ACTB ACTG1

2.08e-0420065487c453bb3fa35fff6417dce1f9b08a335fd1546d
ToppCellCaecum-(1)_T_cell-(17)_gd_T|Caecum / shred on region, Cell_type, and subtype

ACTB ACTG1 PLEKHA1 SLFN5

2.08e-042006542aaa6b37e9f8d95de53f284a42a3ac14e6351b40
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW09-Neuronal|GW09 / Sample Type, Dataset, Time_group, and Cell type.

ANK3 CELF2 ACTB ACTG1

2.08e-0420065409fd3cb31bcc02444f1045f01fe39bce09359d35
ToppCellsevere-immature_Neutrophil|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

ROMO1 SLCO4C1 ACTB PIWIL4

2.08e-042006545ee43386da8261d2e7602a152e6ba4338d844e08
ToppCellMS-Multiple_Sclerosis|MS / Disease, condition lineage and cell class

SLC25A3 ACTB ACTG1 SLFN5

2.08e-04200654dc682a6d230932503565ee0e176b22577b5cf141
ToppCell5'-GW_trimst-1-SmallIntestine-Mesenchymal-immature_mesenchymal_cell-Mesoderm_1_(HAND1+)|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SLC25A3 SFRP1 ACTB ACTG1

2.08e-0420065412ffa9c711b91956f7d8ac9e376e0572122f2112
ToppCell5'-GW_trimst-1-SmallIntestine-Mesenchymal|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SLC25A3 SFRP1 ACTB ACTG1

2.08e-04200654ed941933457f8bf63b277025286ef0485e78f4d0
ToppCellLPS_only-Mesenchymal_myocytic-Pericyte-Pericyte_3|LPS_only / Treatment groups by lineage, cell group, cell type

ARHGAP10 NEXN ADCY1 IL33

2.08e-042006547c62678cf408aaaf98d6df0fb27814d2007c4521
ToppCellCaecum-T_cell-gd_T|Caecum / Region, Cell class and subclass

ACTB ACTG1 PLEKHA1 SLFN5

2.08e-04200654eaacd14b6d4a1c7d52deab110ed3a6c7d3dc1f8e
ToppCell(17)_gd_T|World / shred on Cell_type and subtype

DOCK5 ACTB ACTG1 SLFN5

2.11e-042016547fcfe48758acf07cb3dda939ce589ae1518e41c9
ToppCellThalamus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Six3|Thalamus / BrainAtlas - Mouse McCarroll V32

CHSY3 C2CD6 CLRN1

2.35e-048265347b131333ab84b70d2abe3fc17e63de504214b1b
ToppCellTCGA-Breast-Primary_Tumor-Breast_Carcinoma-Infiltrating_Lobular_Carcinoma-9|TCGA-Breast / Sample_Type by Project: Shred V9

POTEE POTEF POTEI

3.09e-049065396e836c7a1df279ac812b7c3aa75e6b81b614244
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW10-Neuronal-Neuron|GW10 / Sample Type, Dataset, Time_group, and Cell type.

ANK3 ACTB ACTG1

3.09e-0490653840f93af13b5c4dd0eb4132c76f017f97a107e28
Diseaseautosomal dominant nonsyndromic deafness 20 (implicated_via_orthology)

ACTB ACTG1 POTEKP

4.67e-078613DOID:0110550 (implicated_via_orthology)
DiseaseBaraitser-Winter syndrome 1 (implicated_via_orthology)

ACTB ACTG1 POTEKP

4.67e-078613DOID:0081112 (implicated_via_orthology)
DiseaseMoyamoya disease (implicated_via_orthology)

ACTB ACTG1 POTEKP

4.67e-078613DOID:13099 (implicated_via_orthology)
Diseasethoracic aortic aneurysm (implicated_via_orthology)

ACTB ACTG1 POTEKP

4.67e-078613DOID:14004 (implicated_via_orthology)
Diseaseintestinal atresia (implicated_via_orthology)

ACTB ACTG1 POTEKP

9.98e-0710613DOID:10486 (implicated_via_orthology)
Diseasepatent ductus arteriosus (implicated_via_orthology)

ACTB ACTG1 POTEKP

9.98e-0710613DOID:13832 (implicated_via_orthology)
DiseaseIris Coloboma with Ptosis, Hypertelorism, and Mental Retardation

ACTB ACTG1

4.20e-062612C1855722
DiseaseBaraitser-Winter syndrome

ACTB ACTG1

4.20e-062612cv:C1853623
DiseaseFryns-Aftimos Syndrome

ACTB ACTG1

4.20e-062612C1853623
DiseaseUveoretinal Coloboma

ACTB ACTG1

8.77e-057612C4554007
DiseaseCongenital ocular coloboma (disorder)

ACTB ACTG1

1.50e-049612C0009363
DiseaseCongenital neurologic anomalies

ACTB ACTG1

1.87e-0410612C0497552
DiseaseCranioschisis

ACTB ACTG1

1.87e-0410612C0265541
DiseaseAnimal Mammary Neoplasms

RASA1 ACTB ACTG1 XDH

2.17e-04142614C0024667
DiseaseMammary Carcinoma, Animal

RASA1 ACTB ACTG1 XDH

2.17e-04142614C1257925
DiseaseMammary Neoplasms, Experimental

RASA1 ACTB ACTG1 XDH

3.03e-04155614C0024668
DiseaseHeadache

PLEKHA1 MACF1 CHSY3

3.20e-0464613HP_0002315
DiseaseCarcinomatosis

RASA1 ACTB ACTG1 XDH

3.67e-04163614C0205699
DiseaseCarcinoma, Spindle-Cell

RASA1 ACTB ACTG1 XDH

3.67e-04163614C0205697
DiseaseUndifferentiated carcinoma

RASA1 ACTB ACTG1 XDH

3.67e-04163614C0205698
DiseaseAnaplastic carcinoma

RASA1 ACTB ACTG1 XDH

3.67e-04163614C0205696
DiseaseCarcinoma

RASA1 ACTB ACTG1 XDH

3.75e-04164614C0007097
Diseasediastolic blood pressure, systolic blood pressure

RTF1 DOCK5 RANBP10 ANK3 KCNJ5 NEXN ADCY1

4.54e-04670617EFO_0006335, EFO_0006336
Diseasein situ carcinoma (is_marker_for)

SFRP1 CCNB1

8.61e-0421612DOID:8719 (is_marker_for)
Diseasespermatogenic failure (is_implicated_in)

MOV10L1 C2CD6

1.03e-0323612DOID:0111910 (is_implicated_in)

Protein segments in the cluster

PeptideGeneStartEntry
KKCNENDIRVMFSPF

CELF2

141

O95319
IKINFKLTNFPEMMN

COPS2

76

P61201
ENCQRQFCKMMKAKP

TBC1D32

946

Q96NH3
NPKANREKMTQIMFE

POTEKP

111

Q9BYX7
NPKANREKMTQIMFE

ACTB

111

P60709
NPKANREKMTQIMFE

ACTG1

111

P63261
NPMFSKQTIEFKKMF

FAM220BP

211

B1ANY3
GMKFILPNRFDMNVC

ANKRA2

51

Q9H9E1
MFAPAVMRAFRKNKT

COX16

1

Q9P0S2
KCMAFAKFSPAMAQE

DNHD1

1036

Q96M86
EKLRICSMPQFFCFM

AADACL3

61

Q5VUY0
RAQIFKKNCKAMFPN

CC2D2B

1086

Q6DHV5
MDPCKVNELRAFVKM

ST13P5

1

Q8NFI4
PNLLFMLKCRQFVEM

RANBP10

326

Q6VN20
VNPFIKSNKHRMIMF

RASA1

956

P20936
AFMVGCMFVKISQPN

KCNJ9

151

Q92806
PFTHKVNMKARFEQM

NEXN

506

Q0ZGT2
FMVGCMFVKISQPKK

KCNJ5

181

P48544
DRKMEVAFMVCAINP

MEN1

236

O00255
CMYRKAAKKFNMIPF

ARHGAP10

291

A1A4S6
NPKANREKMTQIMFE

POTEF

811

A5A3E0
RQIPYTMMKFACFER

SLC25A3

226

Q00325
KRTGMESQPFLNMKF

IL17RD

141

Q8NFM7
KQFRFQMLDKDQMCP

MOV10L1

316

Q9BXT6
DQMRRKLKFFFMNPC

MCOLN3

36

Q8TDD5
QPEKVMAKQMEFLCN

NAB1

366

Q13506
VQKACMVFQMPDKDE

DDX58

516

O95786
QSESMPDRKMKNVFF

C2CD6

466

Q53TS8
QYMIFHTPFCKMVQK

HMGCS2

296

P54868
YVIFIKPSNMRCMKQ

MPP4

541

Q96JB8
FKMFQKEQVDPLQMK

MACF1

5276

Q9UPN3
NPKANREKMTQIMFE

POTEE

811

Q6S8J3
PAKNKQSVFTRMAVM

PUS10

236

Q3MIT2
KMFKAEIPFSNVMTC

ADCY1

516

Q08828
DRFMQNNCVPKKMLQ

CCNB1

231

P14635
KSQQKAKEVCPMYFM

IL33

31

O95760
RKATIPIFFDMMQCE

DOCK5

1121

Q9H7D0
SPKQYMQCFTVKPVM

DOCK5

1421

Q9H7D0
PMCSAVIDFKQRVFM

BIRC8

221

Q96P09
RNCIGQKFAMAEMKV

CYP4F8

466

P98187
MVTPALQMKKPKQFC

MPG

1

P29372
LQMKKPKQFCRRMGQ

MPG

6

P29372
ICVPYMAKFVVFAKM

ANK3

1306

Q12955
FSCLNVMRLPFMKKL

BLMH

76

Q13867
MKMENFRPNIVVTGC

MTARC2

231

Q969Z3
PNKCKRPMNAFMLFA

HBP1

431

O60381
FKCFAPFRDVPKQMM

FMR1NB

171

Q8N0W7
MKFKQCPTENMAREH

PRPF3

646

O43395
KPNSFVKFRCMIQDM

MCMBP

61

Q9BTE3
KEVLPKMMAFCYQIL

IPO8

406

O15397
MKNQQMDPFTRRQCK

RTF1

586

Q92541
NFKMRPKEIVLMLCQ

TAS2R20

251

P59543
TFTQHQMPLFRKKMV

SENP2

566

Q9HC62
SQPSCFDRVKMGFVM

ROMO1

11

P60602
VRKKCMPRFFTEMNR

PIWIL4

731

Q7Z3Z4
NPKANREKMTQIMFE

POTEI

811

P0CG38
VNCQMRVKKTMPFFL

TDRD7

101

Q8NHU6
NFMKKMKNHECPTFQ

SFRP1

296

Q8N474
RFMENFENMCLIPKQ

CHSY3

636

Q70JA7
MPSQQKKIIFCMAGV

CLRN1

1

P58418
MKRLGSVQRKMPCVF

C12orf29

1

Q8N999
FPAALKNLMKNAVFM

SLCO4C1

371

Q6ZQN7
KMMGIPIRKFICASN

THNSL1

521

Q8IYQ7
IEMKFKNMLFPMIVC

XDH

266

P47989
RNMKTRNMEVFFPKF

SERPINA10

326

Q9UK55
KLEQEFQKVFVMPNM

TEX2

1081

Q8IWB9
TKLRPKAEFCFVMNA

PLEKHA1

71

Q9HB21
ICQPVTRKTFMKNNF

SLFN5

626

Q08AF3
DFTMPKKFVQMLVFN

UGT2A2

6

P0DTE5
DKAFISQAMRCFPKV

NLRP14

591

Q86W24