Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	DNA-binding transcription factor activity, RNA polymerase II-specific	ZNF729 RLF ZNF250 ZBTB34 ZSCAN32 ZNF23 ZNF141 ZNF142 ZBTB17 ZNF732 ZNF382 NFKB1 ZNF189 ZNF485 AHR ZNF620 ZNF479 ZNF75D ZNF778 ZNF225 ZFP69 ZNF774 ZFP62 ZNF284 ZNF404	4.52e-11	1412	77	25	GO:0000981
GeneOntologyMolecularFunction	RNA polymerase II transcription regulatory region sequence-specific DNA binding	ZNF729 ZNF250 ZBTB34 ZSCAN32 ZNF23 ZNF141 ZNF142 ZBTB17 ZNF732 ZNF382 NFKB1 ZNF189 ZNF485 AHR ZNF620 ZNF479 ZNF75D ZNF778 TAF1 ZNF225 ZFP69 ZNF774 ZFP62 ZNF284 ZNF404	9.11e-11	1459	77	25	GO:0000977
GeneOntologyMolecularFunction	RNA polymerase II cis-regulatory region sequence-specific DNA binding	ZNF729 ZNF250 ZBTB34 ZSCAN32 ZNF23 ZNF141 ZBTB17 ZNF732 ZNF382 NFKB1 ZNF189 ZNF485 AHR ZNF479 ZNF75D ZNF778 ZNF225 ZNF774 ZFP62 ZNF284	3.23e-08	1244	77	20	GO:0000978
GeneOntologyMolecularFunction	cis-regulatory region sequence-specific DNA binding	ZNF729 ZNF250 ZBTB34 ZSCAN32 ZNF23 ZNF141 ZBTB17 ZNF732 ZNF382 NFKB1 ZNF189 ZNF485 AHR ZNF479 ZNF75D ZNF778 ZNF225 ZNF774 ZFP62 ZNF284	4.61e-08	1271	77	20	GO:0000987
Domain	ZINC_FINGER_C2H2_1	ZNF729 RLF ZNF250 ZBTB34 ZSCAN32 ZNF137P ZNF23 ZNF141 ZNF142 ZBTB17 ZNF732 ZNF382 TUT7 ZNF189 ZNF485 ZNF620 ZNF479 ZNF75D ZNF778 ZNF225 ZC3H7B ZFP69 ZNF774 ZFP62 ZNF284 ZNF404	2.57e-17	777	77	26	PS00028
Domain	Znf_C2H2	ZNF729 RLF ZNF250 ZBTB34 ZSCAN32 ZNF137P ZNF23 ZNF141 ZNF142 ZBTB17 ZNF732 ZNF382 TUT7 ZNF189 ZNF485 ZNF620 ZNF479 ZNF75D ZNF778 ZNF225 ZC3H7B ZFP69 ZNF774 ZFP62 ZNF284 ZNF404	6.08e-17	805	77	26	IPR007087
Domain	zf-C2H2	ZNF729 RLF ZNF250 ZBTB34 ZSCAN32 ZNF137P ZNF23 ZNF141 ZNF142 ZBTB17 ZNF732 ZNF382 ZNF189 ZNF485 ZNF620 ZNF479 ZNF75D ZNF778 ZNF225 ZFP69 ZNF774 ZFP62 ZNF284 ZNF404	2.69e-16	693	77	24	PF00096
Domain	ZINC_FINGER_C2H2_2	ZNF729 RLF ZNF250 ZBTB34 ZSCAN32 ZNF137P ZNF23 ZNF141 ZNF142 ZBTB17 ZNF732 ZNF382 ZNF189 ZNF485 ZNF620 ZNF479 ZNF75D ZNF778 ZNF225 ZC3H7B ZFP69 ZNF774 ZFP62 ZNF284 ZNF404	2.89e-16	775	77	25	PS50157
Domain	ZnF_C2H2	ZNF729 RLF ZNF250 ZBTB34 ZSCAN32 ZNF137P ZNF23 ZNF141 ZNF142 ZBTB17 ZNF732 ZNF382 ZNF189 ZNF485 ZNF620 ZNF479 ZNF75D ZNF778 ZNF225 ZC3H7B ZFP69 ZNF774 ZFP62 ZNF284 ZNF404	7.61e-16	808	77	25	SM00355
Domain	-	ZNF729 RLF ZNF250 ZBTB34 ZSCAN32 ZNF23 ZNF141 ZNF142 ZBTB17 ZNF732 ZNF382 ZNF189 ZNF485 ZNF620 ZNF479 ZNF75D ZNF778 ZNF225 ZFP69 ZNF774 ZFP62 ZNF284 ZNF404	2.08e-15	679	77	23	3.30.160.60
Domain	Znf_C2H2/integrase_DNA-bd	ZNF729 RLF ZNF250 ZBTB34 ZSCAN32 ZNF23 ZNF141 ZNF142 ZBTB17 ZNF732 ZNF382 ZNF189 ZNF485 ZNF620 ZNF479 ZNF75D ZNF778 ZNF225 ZFP69 ZNF774 ZFP62 ZNF284 ZNF404	3.32e-15	694	77	23	IPR013087
Domain	KRAB	ZNF729 ZNF250 ZSCAN32 ZNF23 ZNF141 ZNF732 ZNF382 ZNF189 ZNF485 ZNF620 ZNF479 ZNF75D ZNF778 ZNF225 ZFP69 ZNF774 ZNF284 ZNF404	4.66e-15	358	77	18	PS50805
Domain	Znf_C2H2-like	ZNF729 RLF ZNF250 ZBTB34 ZSCAN32 ZNF23 ZNF141 ZNF142 ZBTB17 ZNF732 ZNF382 ZNF189 ZNF485 ZNF620 ZNF479 ZNF75D ZNF778 ZNF225 ZC3H7B ZFP69 ZNF774 ZFP62 ZNF284 ZNF404	5.89e-15	796	77	24	IPR015880
Domain	KRAB	ZNF729 ZNF250 ZSCAN32 ZNF23 ZNF141 ZNF732 ZNF382 ZNF189 ZNF485 ZNF620 ZNF479 ZNF75D ZNF778 ZNF225 ZFP69 ZNF284 ZNF404	1.29e-13	370	77	17	IPR001909
Domain	KRAB	ZNF729 ZNF250 ZNF23 ZNF141 ZNF732 ZNF382 ZNF189 ZNF485 ZNF620 ZNF479 ZNF75D ZNF778 ZNF225 ZFP69 ZNF284 ZNF404	1.78e-12	369	77	16	SM00349
Domain	KRAB	ZNF729 ZNF250 ZNF141 ZNF732 ZNF382 ZNF189 ZNF485 ZNF620 ZNF479 ZNF75D ZNF778 ZNF225 ZFP69 ZNF284 ZNF404	1.56e-11	358	77	15	PF01352
Domain	zf-C2H2_6	ZNF729 ZNF250 ZNF141 ZNF732 ZNF382 ZNF620 ZNF479 ZNF778 ZNF225 ZFP62 ZNF284 ZNF404	5.72e-09	314	77	12	PF13912
Domain	FerI	OTOF FER1L5	1.66e-04	5	77	2	SM01202
Domain	FerB	OTOF FER1L5	1.66e-04	5	77	2	SM01201
Domain	Ferlin_B-domain	OTOF FER1L5	1.66e-04	5	77	2	IPR012561
Domain	Ferlin_C	OTOF FER1L5	1.66e-04	5	77	2	PF16165
Domain	Ferlin_C	OTOF FER1L5	1.66e-04	5	77	2	IPR032362
Domain	FerIin_dom	OTOF FER1L5	1.66e-04	5	77	2	IPR012968
Domain	FerI	OTOF FER1L5	1.66e-04	5	77	2	PF08151
Domain	FerB	OTOF FER1L5	1.66e-04	5	77	2	PF08150
Domain	ZF_CCHC	ZCCHC4 XRN2 TUT7	4.01e-04	35	77	3	PS50158
Domain	ZnF_C2HC	ZCCHC4 XRN2 TUT7	1.52e-03	55	77	3	SM00343
Domain	Znf_CCHC	ZCCHC4 XRN2 TUT7	1.52e-03	55	77	3	IPR001878
Domain	SCAN_BOX	ZSCAN32 ZNF75D ZFP69	1.77e-03	58	77	3	PS50804
Pathway	REACTOME_RNA_POLYMERASE_II_TRANSCRIPTION	ZNF729 ZNF250 TRIM33 ZSCAN32 ZNF23 ZNF141 ZNF732 ZNF382 NFKB1 ZNF189 ZNF485 ZNF620 ZNF479 ZNF75D ZNF778 CBX4 TAF1 ZNF225 ZFP69 FAS ZNF774	4.04e-08	1387	57	21	M734
Pathway	WP_SMALL_CELL_LUNG_CANCER	TRAF2 ZBTB17 NFKB1 LAMA2 ITGAV	4.17e-05	96	57	5	M39834
Pubmed	PCSK9 siRNA suppresses the inflammatory response induced by oxLDL through inhibition of NF-κB activation in THP-1-derived macrophages.	NFKB1 PCSK9	4.97e-06	2	78	2	22825241
Pubmed	Fas stimulation activates NF-kappaB in SK-Hep1 hepatocellular carcinoma cells.	NFKB1 FAS	4.97e-06	2	78	2	12883671
Pubmed	Caffeic acid phenethyl ester induces apoptosis by inhibition of NFkappaB and activation of Fas in human breast cancer MCF-7 cells.	NFKB1 FAS	4.97e-06	2	78	2	14625298
Pubmed	Epigenetic control of NF-κB-dependent FAS gene transcription during progression of myelodysplastic syndromes.	NFKB1 FAS	4.97e-06	2	78	2	23604035
Pubmed	Differential role of the transcription factor NF-kappaB in selection and survival of CD4+ and CD8+ thymocytes.	NFKB1 FAS	4.97e-06	2	78	2	18957265
Pubmed	TRAF2 is an NF-κB-activating oncogene in epithelial cancers.	TRAF2 NFKB1	4.97e-06	2	78	2	24362534
Pubmed	Streptococcal pyrogenic exotoxin B-induced apoptosis in A549 cells is mediated through alpha(v)beta(3) integrin and Fas.	FAS ITGAV	4.97e-06	2	78	2	18227168
Pubmed	CD95 and TRAF2 promote invasiveness of pancreatic cancer cells.	TRAF2 FAS	4.97e-06	2	78	2	15670977
Pubmed	Disparity between microRNA levels and promoter strength is associated with initiation rate and Pol II pausing.	NFKB1 TAF1	4.97e-06	2	78	2	23831825
Pubmed	TRAF2 inhibits TRAIL- and CD95L-induced apoptosis and necroptosis.	TRAF2 FAS	4.97e-06	2	78	2	25299769
Pubmed	Isolation and fine mapping of 16 novel human zinc finger-encoding cDNAs identify putative candidate genes for developmental and malignant disorders.	ZNF137P ZNF142 ZBTB17	7.21e-06	17	78	3	7557990
Pubmed	Differential expansion of zinc-finger transcription factor loci in homologous human and mouse gene clusters.	ZNF225 ZNF284 ZNF404	1.20e-05	20	78	3	12743021
Pubmed	Correlated expression of Fas, NF-kappaB, and VEGF-C in infiltrating ductal carcinoma of the breast.	NFKB1 FAS	1.49e-05	3	78	2	23327061
Pubmed	Characterization of signaling pathways leading to Fas expression induced by TNF-alpha: pivotal role of NF-kappaB.	NFKB1 FAS	1.49e-05	3	78	2	15601669
Pubmed	Induction of rapid T cell death and phagocytic activity by Fas-deficient lpr macrophages.	NFKB1 FAS	1.49e-05	3	78	2	23255359
Pubmed	Combined treatment with verrucarin A and tumor necrosis factor-α sensitizes apoptosis by overexpression of nuclear factor-kappaB-mediated Fas.	NFKB1 FAS	1.49e-05	3	78	2	23708311
Pubmed	Identification of SNF1/AMP kinase-related kinase as an NF-kappaB-regulated anti-apoptotic kinase involved in CD95-induced motility and invasiveness.	NFKB1 FAS	1.49e-05	3	78	2	15345718
Pubmed	Induction of apoptosis and activation of NF-kappaB by CD95 require different signalling thresholds.	NFKB1 FAS	1.49e-05	3	78	2	15514680
Pubmed	TRAF2 is essential for JNK but not NF-kappaB activation and regulates lymphocyte proliferation and survival.	TRAF2 FAS	1.49e-05	3	78	2	9390693
Pubmed	Early lethality, functional NF-kappaB activation, and increased sensitivity to TNF-induced cell death in TRAF2-deficient mice.	TRAF2 NFKB1	1.49e-05	3	78	2	9390694
Pubmed	The RING domain of TRAF2 plays an essential role in the inhibition of TNFalpha-induced cell death but not in the activation of NF-kappaB.	TRAF2 NFKB1	1.49e-05	3	78	2	20064526
Pubmed	Fas/S1P1 crosstalk via NF-κB activation in osteoclasts controls subchondral bone remodeling in murine TMJ arthritis.	NFKB1 FAS	1.49e-05	3	78	2	28687489
Pubmed	Resistance to Ara-C up-regulates the activation of NF-kappaB, telomerase activity and Fas expression in NALM-6 cells.	NFKB1 FAS	1.49e-05	3	78	2	17978477
Pubmed	NleB, a bacterial effector with glycosyltransferase activity, targets GAPDH function to inhibit NF-κB activation.	TRAF2 NFKB1	1.49e-05	3	78	2	23332158
Pubmed	NF-κB regulates caspase-4 expression and sensitizes neuroblastoma cells to Fas-induced apoptosis.	NFKB1 FAS	1.49e-05	3	78	2	25695505
Pubmed	Cigarette smoke condensate extracts induce IL-1-beta production from rheumatoid arthritis patient-derived synoviocytes, but not osteoarthritis patient-derived synoviocytes, through aryl hydrocarbon receptor-dependent NF-kappa-B activation and novel NF-kappa-B sites.	NFKB1 AHR	1.49e-05	3	78	2	23452206
Pubmed	Fas activation induces renal tubular epithelial cell beta 8 integrin expression and function in the absence of apoptosis.	FAS ITGAV	1.49e-05	3	78	2	12324452
Pubmed	AhR and Arnt differentially regulate NF-κB signaling and chemokine responses in human bronchial epithelial cells.	NFKB1 AHR	1.49e-05	3	78	2	25201625
Pubmed	Human Adenovirus Type 26 Induced IL-6 Gene Expression in an αvβ3 Integrin- and NF-κB-Dependent Manner.	NFKB1 ITGAV	1.49e-05	3	78	2	35458402
Pubmed	Impact of loss of NF-κB1, NF-κB2 or c-REL on SLE-like autoimmune disease and lymphadenopathy in Fas(lpr/lpr) mutant mice.	NFKB1 FAS	2.97e-05	4	78	2	26084385
Pubmed	Transcriptional factor aryl hydrocarbon receptor (Ahr) controls cardiovascular and respiratory functions by regulating the expression of the Vav3 proto-oncogene.	AHR VAV2	2.97e-05	4	78	2	21115475
Pubmed	IRF-1 inhibits NF-κB activity, suppresses TRAF2 and cIAP1 and induces breast cancer cell specific growth inhibition.	TRAF2 NFKB1	2.97e-05	4	78	2	26011589
Pubmed	The PP4R1 subunit of protein phosphatase PP4 targets TRAF2 and TRAF6 to mediate inhibition of NF-κB activation.	TRAF2 NFKB1	2.97e-05	4	78	2	25134449
Pubmed	Targeting nuclear factor-κB suppresses the negative effect of toll-like receptor 4 signaling on antimetastasis therapy based on targeting αvβ3.	NFKB1 ITGAV	2.97e-05	4	78	2	22494046
Pubmed	Mechanism of allele specific assembly and disruption of master regulator transcription factor complexes of NF-KBp50, NF-KBp65 and HIF1a on a non-coding FAS SNP.	NFKB1 FAS	2.97e-05	4	78	2	27616356
Pubmed	P21-activated kinase 4 interacts with integrin alpha v beta 5 and regulates alpha v beta 5-mediated cell migration.	ZBTB17 ITGAV	2.97e-05	4	78	2	12356872
Pubmed	E3 ubiquitin ligase Trim33 ubiquitylates Annexin A2 to promote NF-κB induced skin inflammation in psoriasis.	TRIM33 NFKB1	2.97e-05	4	78	2	36096861
Pubmed	Interaction of the TNFR-receptor associated factor TRAF1 with I-kappa B kinase-2 and TRAF2 indicates a regulatory function for NF-kappa B signaling.	TRAF2 NFKB1	2.97e-05	4	78	2	20856938
Pubmed	BKCa promotes growth and metastasis of prostate cancer through facilitating the coupling between αvβ3 integrin and FAK.	KCNMA1 ITGAV	2.97e-05	4	78	2	27233075
Pubmed	αvβ3 Integrins Mediate Flow-Induced NF-κB Activation, Proinflammatory Gene Expression, and Early Atherogenic Inflammation.	NFKB1 ITGAV	2.97e-05	4	78	2	26212910
Pubmed	Apoptotic cell-induced AhR activity is required for immunological tolerance and suppression of systemic lupus erythematosus in mice and humans.	AHR FAS	2.97e-05	4	78	2	29760532
Pubmed	TNFα induced noncanonical NF-κB activation is attenuated by RIP1 through stabilization of TRAF2.	TRAF2 NFKB1	2.97e-05	4	78	2	21266470
Pubmed	Two distinct signalling cascades target the NF-kappaB regulatory factor c-IAP1 for degradation.	TRAF2 NFKB1	2.97e-05	4	78	2	19243308
Pubmed	Negative feedback in noncanonical NF-kappaB signaling modulates NIK stability through IKKalpha-mediated phosphorylation.	TRAF2 NFKB1	2.97e-05	4	78	2	20501937
Pubmed	αVβ3 integrin regulates macrophage inflammatory responses via PI3 kinase/Akt-dependent NF-κB activation.	NFKB1 ITGAV	4.94e-05	5	78	2	20672329
Pubmed	Noncanonical NF-kappaB activation requires coordinated assembly of a regulatory complex of the adaptors cIAP1, cIAP2, TRAF2 and TRAF3 and the kinase NIK.	TRAF2 NFKB1	4.94e-05	5	78	2	18997794
Pubmed	Reversible ubiquitination shapes NLRC5 function and modulates NF-κB activation switch.	TRAF2 NFKB1	4.94e-05	5	78	2	26620909
Pubmed	HMGB1 induces human non-small cell lung cancer cell motility by activating integrin αvβ3/FAK through TLR4/NF-κB signaling pathway.	NFKB1 ITGAV	4.94e-05	5	78	2	27769864
Pubmed	Stimulation of Fas (CD95) induces production of pro-inflammatory mediators through ERK/JNK-dependent activation of NF-κB in THP-1 cells.	NFKB1 FAS	4.94e-05	5	78	2	21752354
Pubmed	Vav proteins regulate peripheral B-cell survival.	NFKB1 VAV2	4.94e-05	5	78	2	15941910
Pubmed	Suppressors of cytokine signaling promote Fas-induced apoptosis through downregulation of NF-κB and mitochondrial Bfl-1 in leukemic T cells.	NFKB1 FAS	4.94e-05	5	78	2	23152563
Pubmed	Phosphorylation of ribosomal protein S3 and antiapoptotic TRAF2 protein mediates radioresistance in non-small cell lung cancer cells.	TRAF2 NFKB1	4.94e-05	5	78	2	23188828
Pubmed	Acetylation-Mimic Mutation of TRIM28-Lys304 to Gln Attenuates the Interaction with KRAB-Zinc-Finger Proteins and Affects Gene Expression in Leukemic K562 Cells.	ZNF250 ZCCHC4 ZNF485 ZNF620 ZNF778	5.61e-05	181	78	5	37372979
Pubmed	The inhibitor of apoptosis protein fusion c-IAP2.MALT1 stimulates NF-kappaB activation independently of TRAF1 AND TRAF2.	TRAF2 NFKB1	7.40e-05	6	78	2	16891304
Pubmed	Genetic polymorphisms of IL-1A, IL-1B, IL-1RN, NFKB1, FAS, and FASL, and risk of silicosis in a Chinese occupational population.	NFKB1 FAS	7.40e-05	6	78	2	18666137
Pubmed	Site-specific ubiquitination is required for relieving the transcription factor Miz1-mediated suppression on TNF-α-induced JNK activation and inflammation.	TRAF2 ZBTB17	7.40e-05	6	78	2	22184250
Pubmed	Regulation of the NF-kappaB-inducing kinase by tumor necrosis factor receptor-associated factor 3-induced degradation.	TRAF2 NFKB1	7.40e-05	6	78	2	15084608
Pubmed	RNF4 negatively regulates NF-κB signaling by down-regulating TAB2.	TRAF2 NFKB1	7.40e-05	6	78	2	26299341
Pubmed	TRAF2-binding BIR1 domain of c-IAP2/MALT1 fusion protein is essential for activation of NF-kappaB.	TRAF2 NFKB1	7.40e-05	6	78	2	19234489
Pubmed	TRAF3 forms heterotrimers with TRAF2 and modulates its ability to mediate NF-{kappa}B activation.	TRAF2 NFKB1	7.40e-05	6	78	2	15383523
Pubmed	Involvement of A20 in the molecular switch that activates the non-canonical NF-кB pathway.	TRAF2 NFKB1	7.40e-05	6	78	2	24008839
Pubmed	Modification of gene products involved in resistance to apoptosis in metastatic colon cancer cells: roles of Fas, Apaf-1, NFkappaB, IAPs, Smac/DIABLO, and AIF.	NFKB1 FAS	7.40e-05	6	78	2	17603079
Pubmed	T cell activation-induced and HIV tat-enhanced CD95(APO-1/Fas) ligand transcription involves NF-kappaB.	NFKB1 FAS	7.40e-05	6	78	2	10671224
Pubmed	A20 undermines alternative NF-κB activity and expression of anti-apoptotic genes in Helicobacter pylori infection.	TRAF2 NFKB1	7.40e-05	6	78	2	35089437
Pubmed	HIV-1 Nef interacts with HCV Core, recruits TRAF2, TRAF5 and TRAF6, and stimulates HIV-1 replication in macrophages.	TRAF2 NFKB1	1.04e-04	7	78	2	23774506
Pubmed	Osteopontin increases migration and MMP-9 up-regulation via alphavbeta3 integrin, FAK, ERK, and NF-kappaB-dependent pathway in human chondrosarcoma cells.	NFKB1 ITGAV	1.04e-04	7	78	2	19475568
Pubmed	MCP-induced protein 1 deubiquitinates TRAF proteins and negatively regulates JNK and NF-kappaB signaling.	TRAF2 NFKB1	1.04e-04	7	78	2	21115689
Pubmed	The c-FLIPL cleavage product p43FLIP promotes activation of extracellular signal-regulated kinase (ERK), nuclear factor κB (NF-κB), and caspase-8 and T cell survival.	TRAF2 NFKB1	1.04e-04	7	78	2	24275659
Pubmed	Ubiquitin-associated domain-containing ubiquitin regulatory X (UBX) protein UBXN1 is a negative regulator of nuclear factor κB (NF-κB) signaling.	TRAF2 NFKB1	1.04e-04	7	78	2	25681446
Pubmed	Prevention of hepatic apoptosis and embryonic lethality in RelA/TNFR-1 double knockout mice.	TRAF2 NFKB1	1.38e-04	8	78	2	10702415
Pubmed	The E3 ubiquitin ligase tripartite motif 33 is essential for cytosolic RNA-induced NLRP3 inflammasome activation.	TRIM33 DHX33	1.38e-04	8	78	2	25172487
Pubmed	Inhibiting TRAF2-mediated activation of NF-kappaB facilitates induction of AP-1.	TRAF2 NFKB1	1.38e-04	8	78	2	20133937
Pubmed	Oligomerized TICAM-1 (TRIF) in the cytoplasm recruits nuclear BS69 to enhance NF-kappaB activation and type I IFN induction.	TRAF2 NFKB1	1.38e-04	8	78	2	19795416
Pubmed	Caspase-8 prevents sustained activation of NF-kappaB in monocytes undergoing macrophagic differentiation.	NFKB1 FAS	1.38e-04	8	78	2	17047155
Pubmed	Syk-mediated tyrosine phosphorylation of mule promotes TNF-induced JNK activation and cell death.	TRAF2 ZBTB17	1.38e-04	8	78	2	26212014
Pubmed	Casper is a FADD- and caspase-related inducer of apoptosis.	TRAF2 FAS	1.77e-04	9	78	2	9208847
Pubmed	The extracellular-matrix protein matrilin 2 participates in peripheral nerve regeneration.	MATN2 LAMA2	1.77e-04	9	78	2	19295126
Pubmed	Mechanisms of caspase activation.	TRAF2 FAS	1.77e-04	9	78	2	14644197
Pubmed	Genomic variation associated with mortality among adults of European and African ancestry with heart failure: the cohorts for heart and aging research in genomic epidemiology consortium.	ADAMTS12 KCNMA1	1.77e-04	9	78	2	20400778
Pubmed	Competition between TRAF2 and TRAF6 regulates NF-kappaB activation in human B lymphocytes.	TRAF2 NFKB1	1.77e-04	9	78	2	20449947
Pubmed	USP8 suppresses death receptor-mediated apoptosis by enhancing FLIPL stability.	TRAF2 FAS	1.77e-04	9	78	2	27321185
Pubmed	Rapid and efficient cloning of cDNAs encoding Krüppel-like zinc finger proteins by degenerate PCR.	ZNF729 ZNF778 ZFP62	1.86e-04	49	78	3	9630514
Pubmed	Role of scaffold protein afadin dilute domain-interacting protein (ADIP) in platelet-derived growth factor-induced cell movement by activating Rac protein through Vav2 protein.	ITGAV VAV2	2.21e-04	10	78	2	22027834
Pubmed	GC-B Deficient Mice With Axon Bifurcation Loss Exhibit Compromised Auditory Processing.	OTOF KCNMA1	2.70e-04	11	78	2	30275816
Pubmed	Integrin repertoire on myogenic cells changes during the course of primary myogenesis in the mouse.	LAMA2 ITGAV	2.70e-04	11	78	2	15739233
Pubmed	HIV-1 Nef triggers Vav-mediated signaling pathway leading to functional and morphological differentiation of dendritic cells.	NFKB1 VAV2	2.70e-04	11	78	2	14597672
Pubmed	Genetic variation in tumor necrosis factor and the nuclear factor-kappaB canonical pathway and risk of non-Hodgkin's lymphoma.	TRAF2 NFKB1	2.70e-04	11	78	2	18990758
Pubmed	HIV-1 Nef induces proinflammatory state in macrophages through its acidic cluster domain: involvement of TNF alpha receptor associated factor 2.	TRAF2 NFKB1	2.70e-04	11	78	2	21886773
Pubmed	Functions of Tat: the versatile protein of human immunodeficiency virus type 1.	NFKB1 FAS	3.23e-04	12	78	2	19812265
Pubmed	AIP1/DAB2IP, a novel member of the Ras-GAP family, transduces TRAF2-induced ASK1-JNK activation.	TRAF2 NFKB1	3.23e-04	12	78	2	15310755
Pubmed	The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.	RLF ZNF250 ZNF142 ZNF189 ZNF485 CBX4 ITGAV ATP2B1 RPL8 ZFP62	3.52e-04	1203	78	10	29180619
Pubmed	HIV-1 Nef: hacker of the host cell.	FAS VAV2	3.81e-04	13	78	2	23847689
Pubmed	The ectodermal dysplasia receptor activates the nuclear factor-kappaB, JNK, and cell death pathways and binds to ectodysplasin A.	TRAF2 FAS	3.81e-04	13	78	2	11035039
Pubmed	Proteomics analysis of cardiac extracellular matrix remodeling in a porcine model of ischemia/reperfusion injury.	MATN2 LAMA2 ADAMTS8	4.10e-04	64	78	3	22261194
Pubmed	The kinase IKKα inhibits activation of the transcription factor NF-κB by phosphorylating the regulatory molecule TAX1BP1.	TRAF2 NFKB1	5.12e-04	15	78	2	21765415
Pubmed	Talin 1 and 2 are required for myoblast fusion, sarcomere assembly and the maintenance of myotendinous junctions.	LAMA2 ITGAV	5.12e-04	15	78	2	19793892
Pubmed	Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes.	TRAF2 FAS	5.12e-04	15	78	2	12887920
Pubmed	TAB2 and TAB3 activate the NF-kappaB pathway through binding to polyubiquitin chains.	TRAF2 NFKB1	5.84e-04	16	78	2	15327770
Pubmed	The tyrosine kinase Syk regulates TPL2 activation signals.	TRAF2 NFKB1	5.84e-04	16	78	2	16291755
Pubmed	Transcriptional regulation of a metastasis suppressor gene by Tip60 and beta-catenin complexes.	NFKB1 FAS	7.42e-04	18	78	2	15829968
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF729 RLF ZNF250 ZBTB34 ZSCAN32 ZNF23 ZNF141 ZNF142 ZBTB17 ZNF732 ZNF382 ZNF189 ZNF485 ZNF620 ZNF479 ZNF75D ZNF778 ZNF225 ZFP69 ZNF774 ZFP62 ZNF284 ZNF404	2.93e-16	718	66	23	28
GeneFamily	Ferlin family	OTOF FER1L5	1.95e-04	6	66	2	828
GeneFamily	ADAM metallopeptidases with thrombospondin type 1 motif	ADAMTS12 ADAMTS8	2.16e-03	19	66	2	50
GeneFamily	Zinc fingers CCHC-type\|RNA binding motif containing	ZCCHC4 TUT7	3.73e-03	25	66	2	74
Coexpression	GSE7596_AKT_TRANSD_VS_CTRL_CD4_TCONV_WITH_TGFB_UP	ZNF729 ZCCHC4 TRIM33 XRN2 AHR ITGAV	8.42e-06	160	78	6	M339
ToppCell	Adult-Mesenchymal-chondrocyte-D122\|Adult / Lineage, Cell type, age group and donor	ADAMTS12 TRAF2 LAMA2 ADAMTS8 ABLIM3 TENM2	2.42e-07	148	78	6	81a1e6fdd942a612bf523c59b8b4974f6ca1fdce
ToppCell	Striatum-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Drd1\|Striatum / BrainAtlas - Mouse McCarroll V32	OTOF SLC22A3 DCLK3 ATP2B1 PCSK9	5.86e-06	146	78	5	7b863f9bc63dc1afe015a18a70cd6ed0b71d1f09
ToppCell	3'_v3-GI_small-bowel-Lymphocytic_Invariant-Inducer-like-MAIT\|GI_small-bowel / Manually curated celltypes from each tissue	ANKRD13C MATN2 SEMA6A FAS PCSK9	6.06e-06	147	78	5	4ba9a86ab7033688a9a2a2dc84c001a49af835b4
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L3-5_SST_MAFB\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	OTOF SCARA5 AHR SEMA6A VAV2	2.26e-05	193	78	5	c7e9e6e4bf5e07c9cbdf1aa7c8828f4b2500e3ff
ToppCell	Children_(3_yrs)-Mesenchymal-matrix_fibroblast_1_cell\|Children_(3_yrs) / Lineage, Cell type, age group and donor	ADAMTS12 LAMA2 ADAMTS8 ABLIM3 TENM2	2.26e-05	193	78	5	99525545552b371c86b18b6ea6f4897dc6e9a9ec
ToppCell	Children_(3_yrs)-Mesenchymal-matrix_fibroblast_1_cell-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	ADAMTS12 LAMA2 ADAMTS8 TENM2 VAV2	2.26e-05	193	78	5	b3ad5ff480d99217f36cc7471e5a96a519ddb409
ToppCell	10x3'2.3-week_14-16-Mesenchymal_fibro-stroma-arteriolar_fibroblast\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	ADAMTS12 ANOS1 MATN2 LAMA2 ADAMTS8	2.26e-05	193	78	5	09de51f8ac509e03d480ed3dc9dfe7e7defc59cb
ToppCell	Mesenchymal-matrix_fibroblast_1_cell\|World / Lineage, Cell type, age group and donor	ADAMTS12 LAMA2 ADAMTS8 ABLIM3 TENM2	2.26e-05	193	78	5	acad568621ed677031797b8c2e34dafea798d681
ToppCell	Children_(3_yrs)-Mesenchymal-matrix_fibroblast_1_cell-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	ADAMTS12 LAMA2 ADAMTS8 ABLIM3 VAV2	2.32e-05	194	78	5	e93de9428c986b8943fc169258847c650cfab0e5
ToppCell	Fetal_29-31_weeks-Mesenchymal-matrix_fibroblast_1_cell\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	ADAMTS12 LAMA2 ADAMTS8 ABLIM3 TENM2	2.32e-05	194	78	5	011e14d9ed1393275f892060e7708ffadcd0767f
ToppCell	Fetal_29-31_weeks-Mesenchymal-matrix_fibroblast_1_cell-D062\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	ADAMTS12 LAMA2 ABLIM3 TENM2 VAV2	2.32e-05	194	78	5	35f132cc38ac133be01834ed0946188aa0757eb4
ToppCell	Bronchial-NucSeq-Stromal-Peri/Epineurial_-NAF_endoneurial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	LAMA2 FAS ABLIM3 NPEPL1 TENM2	2.49e-05	197	78	5	6806ec223e542f0475303698eb78c1cc527f5c6b
ToppCell	Tracheal-NucSeq-Stromal-Peri/Epineurial_\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	ADAMTS12 MATN2 SLC22A3 LAMA2 TENM2	2.61e-05	199	78	5	3835452e4848d7f7dd8651c17b746b271ef39688
ToppCell	Bronchial-10x5prime-Stromal-Peri/Epineurial_\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	ADAMTS12 MATN2 SLC22A3 LAMA2 TENM2	2.61e-05	199	78	5	45c3b853900d8c3d5965117d904e3714100138bc
ToppCell	Tracheal-NucSeq-Stromal-Peri/Epineurial_-NAF_epineurial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	ADAMTS12 MATN2 SLC22A3 LAMA2 TENM2	2.61e-05	199	78	5	9c2db0bb94cba71a3cc1827844da090e213e0258
ToppCell	Neuronal-Inhibitory-iB-iB_4(SST)-ADGRG6-\|Neuronal / cells hierarchy compared to all cells using T-Statistic	OTOF SCARA5 AHR SEMA6A VAV2	2.68e-05	200	78	5	a9cdddc4e985dae59521e557479c24fcc2ac727d
ToppCell	Neuronal-Inhibitory-iB-iB_4(SST)-ADGRG6--L3-5\|Neuronal / cells hierarchy compared to all cells using T-Statistic	OTOF SCARA5 AHR SEMA6A VAV2	2.68e-05	200	78	5	33b9199e0dfc267e2cea20b82d1c167f8adcc635
ToppCell	Parenchymal-10x3prime_v2-Stromal-Peri/Epineurial_\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	ADAMTS12 SLC22A3 ZNF189 LAMA2 ZNF225	2.68e-05	200	78	5	5ad3ea1cf1fcd4100966c5517bc7ed0a1af54317
ToppCell	Bronchial-10x5prime-Stromal-Peri/Epineurial_-NAF_endoneurial\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	ADAMTS12 MATN2 SLC22A3 LAMA2 TENM2	2.68e-05	200	78	5	29054cf55e88e1ac81a562d8dd9af9b7c749321d
ToppCell	Neuronal-Inhibitory-iB-iB_4(SST)-ADGRG6\|Neuronal / cells hierarchy compared to all cells using T-Statistic	OTOF SCARA5 AHR SEMA6A VAV2	2.68e-05	200	78	5	9719fabddc34051949468a7520289e3c750de4f8
Drug	Graveoline [485-61-0]; Down 200; 14.4uM; HL60; HT_HG-U133A	ZNF250 TRAF2 ZNF142 CBX4 ZNF225 ZC3H7B NPEPL1	4.55e-06	196	77	7	2179_DN
Drug	Dimenhydrinate [523-87-5]; Down 200; 8.6uM; HL60; HT_HG-U133A	ZNF250 ZSCAN32 TRAF2 ZNF75D ZC3H7B FAS ATP2B1	5.03e-06	199	77	7	2400_DN
Disease	severe acute respiratory syndrome, COVID-19	ADAMTS12 ZCCHC4 ANOS1 ZNF732 KCNMA1 ABLIM3 TENM2	1.10e-04	447	72	7	EFO_0000694, MONDO_0100096
Disease	limb-girdle muscular dystrophy (implicated_via_orthology)	OTOF FER1L5	1.22e-04	7	72	2	DOID:11724 (implicated_via_orthology)
Disease	creatinine measurement	KIF21B ZBTB17 SLC22A3 NFKB1 KCNMA1 AHR LAMA2 ATP9B ABLIM3	6.89e-04	995	72	9	EFO_0004518
Disease	alcoholic hepatitis (biomarker_via_orthology)	NFKB1 FAS	8.76e-04	18	72	2	DOID:12351 (biomarker_via_orthology)
Disease	smoking cessation	CHRNA6 ATXN7L1 KCNMA1 ZC3H7B TENM2	1.20e-03	325	72	5	EFO_0004319
Disease	Splenomegaly	AHR FAS	1.31e-03	22	72	2	C0038002
Disease	Behcet Syndrome	AHR FAS	1.57e-03	24	72	2	C0004943
Disease	PCSK9 protein measurement	ATXN7L1 PCSK9	1.84e-03	26	72	2	EFO_0006899
Disease	factor VIII measurement, coronary artery disease	SCARA5 ATP2B1 PCSK9	2.69e-03	113	72	3	EFO_0001645, EFO_0004630
Disease	response to aromatase inhibitor	ATXN7L1 MATN2	2.78e-03	32	72	2	GO_0061477
Disease	von Willebrand factor measurement, coronary artery disease	SCARA5 ATP2B1 PCSK9	3.04e-03	118	72	3	EFO_0001645, EFO_0004629
Disease	Vasodilators used in cardiac diseases use measurement	ATP2B1 PCSK9	3.13e-03	34	72	2	EFO_0009926
Disease	melanoma (is_implicated_in)	NFKB1 FAS	3.13e-03	34	72	2	DOID:1909 (is_implicated_in)
Disease	Growth Disorders	KCNMA1 AHR	3.51e-03	36	72	2	C0018273
Disease	duodenal ulcer	SLC22A3 TTLL8	3.51e-03	36	72	2	EFO_0004607
Disease	triglycerides to total lipids in large VLDL percentage	SLC22A3 PCSK9	4.10e-03	39	72	2	EFO_0022332
Disease	response to glucocorticoid, osteonecrosis	KCNMA1 CBX4	4.10e-03	39	72	2	EFO_0004259, GO_0051384

Protein segments in the cluster

Peptide	Gene	Start	Entry
HKLDFTPIGCDAKGR	AHR	291	P35869
RGPSHCAGCKEEIKH	ABLIM3	146	O94929
CDHVVDSPRKLDKCG	ADAMTS8	666	Q9UP79
GKAPHLGRELVCKES	ANKRD13C	431	Q8N6S4
SKIELCEEHGCGGLR	C14orf28	196	Q4W4Y0
RCPGEIIEGKKSCLN	DDTL	111	A6NHG4
KCGILHPGEDFLCLE	ATP2B1	721	P20020
HCGVLDPETKKPCTR	ATXN7L1	296	Q9ULK2
ATCGPHGEKKRTVLC	ADAMTS12	896	P58397
GDRCRCEHSKPLKQE	MKRN4P	136	Q13434
CLEPCKESGDLRKHQ	ANOS1	86	P23352
PEGHVLRSDGKTCAK	MATN2	511	O00339
EDGRRCKKCTEGPID	MATN2	641	O00339
HDDITDPKRIKKCGC	KCNMA1	681	Q12791
GCPEKCEEKHPRNSI	ATP9B	121	O43861
KALKGDHRCGETETP	DCLK3	46	Q9C098
CHAPGLECKVKEHGI	PCSK9	601	Q8NBP7
ACVKAGRKCGDLVHP	NPEPL1	396	Q8NDH3
RPQLSKEKIEGCHIC	KIF21B	16	O75037
CVKDEKHARRGLAPG	LAMA2	426	P24043
GPEACGKRELAHRLC	LRGUK	421	Q96M69
TIVCCLEEKPGDRGK	RPL8	111	P62917
CHLEPGEKLRELCGT	PHKG2	176	P15735
LPKLEGHTCEKCREL	PRICKLE4	76	Q2TBC4
GHTCEKCRELLKPGE	PRICKLE4	81	Q2TBC4
GKLASHGEPRHLKEC	CHRNA6	381	Q15825
HILLDCGEDNVCKPK	ITGAV	621	P06756
KRCLSETHGEREPCK	CBX4	411	O00257
KTCRDIAKHLPDGCP	DHX33	306	Q9H6R0
ALLTGKDCPHVREKG	ELMO3	601	Q96BJ8
RGGCKEEINDPKEIC	DNAAF1	36	Q8NEP3
GKCRHECHDFEKPIG	DEFB133	36	Q30KQ1
KLNLCEDGPCHKRRA	SCARA5	31	Q6ZMJ2
DVEKLGSPHSCKCGR	SLC22A3	531	O75751
LTRLCKDGKVDGPHF	OTOF	1616	Q9HC10
CEKRILEAVGCTGHP	PKN3	606	Q6P5Z2
HGVKGCLECDPKFIE	IZUMO3	16	Q5VZ72
LHCCELIERPSKKDG	OSBPL5	171	Q9H0X9
CLEGEECKVLPDRKG	TAFA2	101	Q8N3H0
GGDLLCCEKCPKVFH	TRIM33	896	Q9UPN9
RVLDCRKKDCPDEIG	FER1L5	391	A0AVI2
ERPDLKLKCGACGAI	TAF1	1256	P21675
GQEAEKILCKGLPHC	FBXL12	296	Q9NXK8
HPRCIEHGTCKDGKC	TENM2	771	Q9NT68
KTLGCADKGEAHRRP	SPATA31E1	1196	Q6ZUB1
PGCTEEINDLHDKCK	WDR17	1061	Q8IZU2
KPGIICVEGFKEHCE	RWDD2A	191	Q9UIY3
CPACKGLVRLGEKER	TRAF2	136	Q12933
KIHTGEKPFLCIECG	ZNF189	336	O75820
KAAGKVELPACPCRH	TTLL8	686	A6PVC2
RIHAAEKPCECKECG	ZNF778	301	Q96MU6
IHTGEKPHECLECRK	ZNF250	276	P15622
RIHTGEKPHKCSECG	ZSCAN32	541	Q9NX65
KCDHEGPCSVDRLKG	RLF	1211	Q13129
EHCDPCTKCEHGIIK	FAS	141	P25445
CVIKVPLGRCERHGK	SEMA6A	506	Q9H2E6
ECPECGKTFGRKPHL	ZNF774	236	Q6NX45
HEVKDCEGLPREKKG	XRN2	271	Q9H0D6
CEGLPREKKGKHDEL	XRN2	276	Q9H0D6
RIHTGEKPFECKECG	ZNF620	356	Q6ZNG0
TGEKPHKCDDCGKVL	ZNF137P	151	P52743
IHAGEKPITCEECRK	ZNF141	276	Q15928
KRIHTGEKPCRCEEC	ZNF479	316	Q96JC4
IHVGLKPFECKECGE	ZNF404	236	Q494X3
RIHSGEKPFKCEECG	ZNF225	476	Q9UK10
KIHIADGPLKCRECG	ZBTB17	466	Q13105
RIHTGEKPFKCDECG	ZNF75D	441	P51815
PKHGCFICGELDHKR	ZCCHC4	441	Q9H5U6
IHTREKPFGCDECGK	ZFP62	526	Q8NB50
RVHLGEKPFKCVECG	ZFP62	721	Q8NB50
RLHSGEKPFKCVECG	ZNF23	216	P17027
LLHTGEKPHKCELCD	ZNF142	421	P52746
KCGVGAHKECLEVIP	VAV2	556	P52735
IHTGERPHKCEECGK	ZNF732	411	B4DXR9
SLCKREGHLKKDCPE	TUT7	966	Q5VYS8
HIEGKPFICIDCGKS	ZNF382	346	Q96SR6
RIHSREKPHKCIECG	ZNF485	206	Q8NCK3
KLHTGEKPHICEECG	ZNF284	251	Q2VY69
GHTDDKPFRCEICGK	ZBTB34	421	Q8NCN2
VIHTGEKPCKCEECG	ZNF729	816	A6NN14
RIHTGEKPFRCKECG	ZFP69	291	Q49AA0
LCDRLQKGKACPDGD	ZC3H7B	891	Q9UGR2
KHCEDGICTVTAGPK	NFKB1	116	P19838