Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	voltage-gated sodium channel activity	SCN4A SCN7A SCN9A	1.45e-04	26	79	3	GO:0005248
GeneOntologyMolecularFunction	ephrin receptor binding	ABL1 NGEF CDK5	2.72e-04	32	79	3	GO:0046875
GeneOntologyCellularComponent	voltage-gated sodium channel complex	SCN4A SCN7A SCN9A	3.40e-05	17	79	3	GO:0001518
GeneOntologyCellularComponent	sodium channel complex	SCN4A SCN7A SCN9A	1.77e-04	29	79	3	GO:0034706
Domain	Na_channel_asu	SCN4A SCN7A SCN9A	8.89e-06	10	80	3	IPR001696
Domain	Na_trans_assoc	SCN4A SCN7A SCN9A	8.89e-06	10	80	3	IPR010526
Domain	Na_trans_assoc	SCN4A SCN7A SCN9A	8.89e-06	10	80	3	PF06512
Domain	COUP_TF	NR2F1 NR2F2	1.80e-04	5	80	2	IPR003068
Domain	GDS_CDC24_CS	ARHGEF5 NGEF VAV3	6.19e-04	39	80	3	IPR001331
Domain	COMM	COMMD7 COMMD10	7.97e-04	10	80	2	IPR017920
Domain	COMM_domain	COMMD7 COMMD10	7.97e-04	10	80	2	PF07258
Domain	COMM	COMMD7 COMMD10	7.97e-04	10	80	2	PS51269
Domain	Helicase_C	DDX60L ASCC3 DDX55 ZRANB3	1.15e-03	107	80	4	PF00271
Domain	HELICc	DDX60L ASCC3 DDX55 ZRANB3	1.15e-03	107	80	4	SM00490
Domain	Helicase_C	DDX60L ASCC3 DDX55 ZRANB3	1.19e-03	108	80	4	IPR001650
Domain	HELICASE_CTER	DDX60L ASCC3 DDX55 ZRANB3	1.23e-03	109	80	4	PS51194
Domain	HELICASE_ATP_BIND_1	DDX60L ASCC3 DDX55 ZRANB3	1.23e-03	109	80	4	PS51192
Domain	DEXDc	DDX60L ASCC3 DDX55 ZRANB3	1.23e-03	109	80	4	SM00487
Domain	Helicase_ATP-bd	DDX60L ASCC3 DDX55 ZRANB3	1.28e-03	110	80	4	IPR014001
Domain	Channel_four-helix_dom	SCN4A SCN7A SCN9A	1.87e-03	57	80	3	IPR027359
Domain	-	SCN4A SCN7A SCN9A	1.87e-03	57	80	3	1.20.120.350
Domain	DH_1	ARHGEF5 NGEF VAV3	2.50e-03	63	80	3	PS00741
Domain	Integrin_alpha-2	ITGA11 ITGAX	2.65e-03	18	80	2	IPR013649
Domain	Integrin_alpha2	ITGA11 ITGAX	2.65e-03	18	80	2	PF08441
Domain	Integrin_alpha	ITGA11 ITGAX	2.65e-03	18	80	2	IPR000413
Domain	INTEGRIN_ALPHA	ITGA11 ITGAX	2.65e-03	18	80	2	PS00242
Domain	Int_alpha_beta-p	ITGA11 ITGAX	2.96e-03	19	80	2	IPR013519
Domain	Int_alpha	ITGA11 ITGAX	2.96e-03	19	80	2	SM00191
Domain	RhoGEF	ARHGEF5 NGEF VAV3	3.10e-03	68	80	3	SM00325
Domain	ARM-type_fold	USP34 RIF1 INTS4 NUP188 ODAD2 NCDN	3.33e-03	339	80	6	IPR016024
Domain	RhoGEF	ARHGEF5 NGEF VAV3	3.37e-03	70	80	3	PF00621
Domain	DH_2	ARHGEF5 NGEF VAV3	3.37e-03	70	80	3	PS50010
Domain	DH-domain	ARHGEF5 NGEF VAV3	3.51e-03	71	80	3	IPR000219
Domain	-	ARHGEF5 NGEF VAV3	3.51e-03	71	80	3	1.20.900.10
Domain	DEAD/DEAH_box_helicase_dom	DDX60L ASCC3 DDX55	3.79e-03	73	80	3	IPR011545
Domain	DEAD	DDX60L ASCC3 DDX55	3.79e-03	73	80	3	PF00270
Domain	FG_GAP	ITGA11 ITGAX	3.96e-03	22	80	2	PS51470
Domain	FG-GAP	ITGA11 ITGAX	4.70e-03	24	80	2	PF01839
Domain	FG-GAP	ITGA11 ITGAX	4.70e-03	24	80	2	IPR013517
Domain	IQ	SCN4A SCN7A SCN9A	5.08e-03	81	80	3	SM00015
Domain	Integrin_dom	ITGA11 ITGAX	5.10e-03	25	80	2	IPR032695
Domain	SH3_1	ABL1 ARHGEF5 NGEF VAV3	5.40e-03	164	80	4	PF00018
Domain	IQ_motif_EF-hand-BS	SCN4A SCN7A SCN9A	6.80e-03	90	80	3	IPR000048
Pubmed	COUP-TFI and -TFII nuclear receptors are expressed in amacrine cells and play roles in regulating the differentiation of retinal progenitor cells.	NR2F1 NR2F2	5.23e-06	2	80	2	19766631
Pubmed	State- and use-dependent block of muscle Nav1.4 and neuronal Nav1.7 voltage-gated Na+ channel isoforms by ranolazine.	SCN4A SCN9A	5.23e-06	2	80	2	18079277
Pubmed	Localization of the cellular oncogenes ABL, SIS, and FES on human germ-line chromosomes.	ABL1 FES	5.23e-06	2	80	2	6323103
Pubmed	Novel NR2F1 variants likely disrupt DNA binding: molecular modeling in two cases, review of published cases, genotype-phenotype correlation, and phenotypic expansion of the Bosch-Boonstra-Schaaf optic atrophy syndrome.	NR2F1 NR2F2	5.23e-06	2	80	2	28963436
Pubmed	An evolutionary conserved COUP-TF binding element in a neural-specific gene and COUP-TF expression patterns support a major role for COUP-TF in neural development.	NR2F1 NR2F2	5.23e-06	2	80	2	7708064
Pubmed	Chicken ovalbumin upstream promoter transcription factor (COUP-TF): expression during mouse embryogenesis.	NR2F1 NR2F2	5.23e-06	2	80	2	7626501
Pubmed	Spatiotemporal expression patterns of chicken ovalbumin upstream promoter-transcription factors in the developing mouse central nervous system: evidence for a role in segmental patterning of the diencephalon.	NR2F1 NR2F2	5.23e-06	2	80	2	8183930
Pubmed	Localization of transcripts of the related nuclear orphan receptors COUP-TF I and ARP-1 in the adult mouse brain.	NR2F1 NR2F2	5.23e-06	2	80	2	7609634
Pubmed	Dynamic expression of COUP-TFI and COUP-TFII during development and functional maturation of the mouse inner ear.	NR2F1 NR2F2	5.23e-06	2	80	2	15907456
Pubmed	Requirement for COUP-TFI and II in the temporal specification of neural stem cells in CNS development.	NR2F1 NR2F2	5.23e-06	2	80	2	19160499
Pubmed	All-trans retinoic acid affects the expression of orphan receptors COUP-TF I and COUP-TF II in the developing neural tube.	NR2F1 NR2F2	5.23e-06	2	80	2	8804707
Pubmed	The Transcription Factors COUP-TFI and COUP-TFII have Distinct Roles in Arealisation and GABAergic Interneuron Specification in the Early Human Fetal Telencephalon.	NR2F1 NR2F2	5.23e-06	2	80	2	28922831
Pubmed	Structural coupling of SH2-kinase domains links Fes and Abl substrate recognition and kinase activation.	ABL1 FES	5.23e-06	2	80	2	18775312
Pubmed	Hhex is Required at Multiple Stages of Adult Hematopoietic Stem and Progenitor Cell Differentiation.	SLC17A2 COMMD10	1.57e-05	3	80	2	25968920
Pubmed	Exome sequencing reveals new causal mutations in children with epileptic encephalopathies.	CLCN4 ARHGEF5	1.57e-05	3	80	2	23647072
Pubmed	Cooperative roles of c-Abl and Cdk5 in regulation of p53 in response to oxidative stress.	ABL1 CDK5	1.57e-05	3	80	2	18490454
Pubmed	Human voltage-gated sodium channel mutations that cause inherited neuronal and muscle channelopathies increase resurgent sodium currents.	SCN4A SCN9A	1.57e-05	3	80	2	20038812
Pubmed	Chicken ovalbumin upstream promoter-transcription factor (COUP-TF) modulates expression of the Purkinje cell protein-2 gene. A potential role for COUP-TF in repressing premature thyroid hormone action in the developing brain.	NR2F1 NR2F2	1.57e-05	3	80	2	9632703
Pubmed	c-Abl tyrosine kinase modulates tau pathology and Cdk5 phosphorylation in AD transgenic mice.	ABL1 CDK5	1.57e-05	3	80	2	19700222
Pubmed	Transcription factors COUP-TFI and COUP-TFII are required for the production of granule cells in the mouse olfactory bulb.	NR2F1 NR2F2	1.57e-05	3	80	2	25922524
Pubmed	Chicken ovalbumin upstream promoter-transcription factor members repress retinoic acid-induced Cdx1 expression.	NR2F1 NR2F2	1.57e-05	3	80	2	15677473
Pubmed	The nuclear orphan receptor NR2F6 suppresses lymphocyte activation and T helper 17-dependent autoimmunity.	NR2F1 NR2F2	1.57e-05	3	80	2	18701084
Pubmed	Regulation of vascular endothelial growth factor D by orphan receptors hepatocyte nuclear factor-4 alpha and chicken ovalbumin upstream promoter transcription factors 1 and 2.	NR2F1 NR2F2	3.13e-05	4	80	2	18199540
Pubmed	Evolution and diversity of mammalian sodium channel genes.	SCN7A SCN9A	3.13e-05	4	80	2	10198179
Pubmed	The COUP-TF nuclear receptors regulate cell migration in the mammalian basal forebrain.	NR2F1 NR2F2	3.13e-05	4	80	2	15548577
Pubmed	Isolation of a novel family of C(2)H(2) zinc finger proteins implicated in transcriptional repression mediated by chicken ovalbumin upstream promoter transcription factor (COUP-TF) orphan nuclear receptors.	NR2F1 NR2F2	3.13e-05	4	80	2	10744719
Pubmed	Cables links Cdk5 and c-Abl and facilitates Cdk5 tyrosine phosphorylation, kinase upregulation, and neurite outgrowth.	ABL1 CDK5	5.20e-05	5	80	2	10896159
Pubmed	Cdk5 regulates EphA4-mediated dendritic spine retraction through an ephexin1-dependent mechanism.	NGEF CDK5	5.20e-05	5	80	2	17143272
Pubmed	A role for Sp and nuclear receptor transcription factors in a cardiac hypertrophic growth program.	NR2F1 NR2F2	5.20e-05	5	80	2	9177236
Pubmed	Isolation of complement-fragment-iC3b-binding proteins by affinity chromatography. The identification of p150,95 as an iC3b-binding protein.	ABL1 ITGAX	5.20e-05	5	80	2	4062888
Pubmed	ik3-2, a relative to ik3-1/cables, is associated with cdk3, cdk5, and c-abl.	ABL1 CDK5	5.20e-05	5	80	2	11955625
Pubmed	Defining the membrane proteome of NK cells.	CNST ERAP1 FARSB LRRC40 NUP188 ASCC3 DDX55 IL1RAP ITGAX RPL4 NCDN	7.35e-05	1168	80	11	19946888
Pubmed	Organization, sequence, chromosomal localization, and promoter identification of the mouse orphan nuclear receptor Nurr1 gene.	ABL1 SCN9A	7.79e-05	6	80	2	9143501
Pubmed	Cloning and expression during development of three murine members of the COUP family of nuclear orphan receptors.	NR2F1 NR2F2	7.79e-05	6	80	2	7947324
Pubmed	The transcription factor Rfx7 limits metabolism of NK cells and promotes their maintenance and immunity.	COMMD10 RFX5	7.79e-05	6	80	2	29967452
Pubmed	A protein interaction landscape of breast cancer.	PMS1 ERAP1 FARSB PDCD11 NUP188 RPL4 MRPL9 CDK5	1.07e-04	634	80	8	34591612
Pubmed	A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.	USP34 PSMG2 COMMD7 COMMD10 FARSB PDCD11 DDX60L NUP188 ASCC3 HPSE MRPL9 CDK5	1.08e-04	1440	80	12	30833792
Pubmed	Angiopoietin receptor Tie2 is required for vein specification and maintenance via regulating COUP-TFII.	COMMD10 NR2F2	1.09e-04	7	80	2	28005008
Pubmed	CoupTFI interacts with retinoic acid signaling during cortical development.	NR2F1 NR2F2	1.09e-04	7	80	2	23472160
Pubmed	The orphan nuclear receptors COUP-TFI and COUP-TFII regulate expression of the gonadotropin LHβ gene.	NR2F1 NR2F2	1.09e-04	7	80	2	20797425
Pubmed	Genome-wide association analysis identifies new lung cancer susceptibility loci in never-smoking women in Asia.	BPTF RIF1	1.45e-04	8	80	2	23143601
Pubmed	Discovery of genes required for body axis and limb formation by global identification of retinoic acid-regulated epigenetic marks.	NR2F1 NR2F2	1.45e-04	8	80	2	32421711
Pubmed	Isolation, characterization, and chromosomal localization of mouse and human COUP-TF I and II genes.	NR2F1 NR2F2	1.86e-04	9	80	2	8530078
Pubmed	International Union of Pharmacology. XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channels.	SCN4A SCN9A	1.86e-04	9	80	2	16382098
Pubmed	Zic4-Lineage Cells Increase Their Contribution to Visual Thalamic Nuclei during Murine Embryogenesis If They Are Homozygous or Heterozygous for Loss of Pax6 Function.	NR2F1 NR2F2	1.86e-04	9	80	2	30406191
Pubmed	Long noncoding RNA lncKdm2b is required for ILC3 maintenance by initiation of Zfp292 expression.	BPTF COMMD10	1.86e-04	9	80	2	28319097
Pubmed	mGluR5 hypofunction is integral to glutamatergic dysregulation in schizophrenia.	NCDN CDK5	1.86e-04	9	80	2	30214040
Pubmed	Genetic mapping of the peripheral sodium channel genes, Scn9a and Scn10a, in the mouse.	ABL1 SCN9A	1.86e-04	9	80	2	8854872
Pubmed	A dynamic balance between ARP-1/COUP-TFII, EAR-3/COUP-TFI, and retinoic acid receptor:retinoid X receptor heterodimers regulates Oct-3/4 expression in embryonal carcinoma cells.	NR2F1 NR2F2	1.86e-04	9	80	2	7823919
Pubmed	A Damage-Independent Role for 53BP1 that Impacts Break Order and Igh Architecture during Class Switch Recombination.	RIF1 COMMD10	2.32e-04	10	80	2	27320916
Pubmed	Intersubspecific subcongenic mouse strain analysis reveals closely linked QTLs with opposite effects on body weight.	SCN7A SCN9A	2.32e-04	10	80	2	21451961
Pubmed	The nuclear hormone receptor Coup-TFII is required for the initiation and early maintenance of Prox1 expression in lymphatic endothelial cells.	COMMD10 NR2F2	2.32e-04	10	80	2	20360386
Pubmed	COUP-TFs regulate eye development by controlling factors essential for optic vesicle morphogenesis.	NR2F1 NR2F2	2.84e-04	11	80	2	20147377
Pubmed	Sequence-specific recognition of a PxLPxI/L motif by an ankyrin repeat tumbler lock.	ABL1 RFX5	2.84e-04	11	80	2	22649097
Pubmed	A dual-color FISH gene map of the proximal region of rat Chromosome 4 and comparative analysis in human and mouse.	ARHGEF5 CDK5	2.84e-04	11	80	2	11707776
Pubmed	Genome-wide association study of a heart failure related metabolomic profile among African Americans in the Atherosclerosis Risk in Communities (ARIC) study.	APCDD1 NAT8 COMMD10	2.98e-04	56	80	3	23934736
Pubmed	Large-scale analysis of ion channel gene expression in the mouse heart during perinatal development.	CLCN4 SCN4A SCN7A SCN9A	3.05e-04	139	80	4	16985003
Pubmed	Transcriptional regulation by the repressor of estrogen receptor activity via recruitment of histone deacetylases.	NR2F1 NR2F2	3.40e-04	12	80	2	15140878
Pubmed	The spatial patterning of mouse cone opsin expression is regulated by bone morphogenetic protein signaling through downstream effector COUP-TF nuclear receptors.	NR2F1 NR2F2	3.40e-04	12	80	2	19812316
Pubmed	Local phosphatidylinositol 3,4,5-trisphosphate accumulation recruits Vav2 and Vav3 to activate Rac1/Cdc42 and initiate neurite outgrowth in nerve growth factor-stimulated PC12 cells.	LINGO1 VAV3	3.40e-04	12	80	2	15728722
Pubmed	Regulation and binding of pregnane X receptor by nuclear receptor corepressor silencing mediator of retinoid and thyroid hormone receptors (SMRT).	NR2F1 NR2F2	3.40e-04	12	80	2	16219912
Pubmed	COUP-TFI is required for the formation of commissural projections in the forebrain by regulating axonal growth.	NR2F1 CDK5	3.40e-04	12	80	2	17021036
Pubmed	A collection of cDNAs enriched in upper cortical layers of the embryonic mouse brain.	PDCD11 LRRC40 TLCD3A	3.47e-04	59	80	3	15010206
Pubmed	The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.	BPTF RIF1 FARSB PDCD11 ASCC3 DDX55 RPL4 NR2F2	3.60e-04	759	80	8	35915203
Pubmed	EphB-mediated degradation of the RhoA GEF Ephexin5 relieves a developmental brake on excitatory synapse formation.	ARHGEF5 NGEF	4.01e-04	13	80	2	21029865
Pubmed	Origin, specification and differentiation of a rare supporting-like lineage in the developing mouse gonad.	NR2F1 NR2F2	4.01e-04	13	80	2	35613264
Pubmed	Gradient COUP-TFI Expression Is Required for Functional Organization of the Hippocampal Septo-Temporal Longitudinal Axis.	NR2F1 NR2F2	4.67e-04	14	80	2	26813976
Pubmed	The expression profiles of nuclear receptors in the developing and adult kidney.	NR2F1 NR2F2	4.67e-04	14	80	2	16973757
Pubmed	Targeted ubiquitination and degradation of G-protein-coupled receptor kinase 5 by the DDB1-CUL4 ubiquitin ligase complex.	RBMS1 CTDP1 RPL4 NR2F1	4.73e-04	156	80	4	22952844
Pubmed	Mutation specific functions of EGFR result in a mutation-specific downstream pathway activation.	ARHGEF5 VAV3 NCDN	5.27e-04	68	80	3	25754235
Pubmed	A novel pair of immunoglobulin-like receptors expressed by B cells and myeloid cells.	CLCN4 LILRA4	5.38e-04	15	80	2	9144225
Pubmed	Spatial and temporal regulation of Wnt/beta-catenin signaling is essential for development of the retinal pigment epithelium.	NR2F1 NR2F2	6.14e-04	16	80	2	19596317
Pubmed	Stem cell factor induces phosphatidylinositol 3'-kinase-dependent Lyn/Tec/Dok-1 complex formation in hematopoietic cells.	ABL1 FES	6.14e-04	16	80	2	11071635
Pubmed	Reduced expression of the Kinesin-Associated Protein 3 (KIFAP3) gene increases survival in sporadic amyotrophic lateral sclerosis.	RBMS1 SCN7A	6.14e-04	16	80	2	19451621
Pubmed	COMMD proteins, a novel family of structural and functional homologs of MURR1.	COMMD7 COMMD10	6.14e-04	16	80	2	15799966
Pubmed	Enhanced prediction of Src homology 2 (SH2) domain binding potentials using a fluorescence polarization-derived c-Met, c-Kit, ErbB, and androgen receptor interactome.	ABL1 FES VAV3	6.49e-04	73	80	3	24728074
Pubmed	Comparative Application of BioID and TurboID for Protein-Proximity Biotinylation.	USP34 RIF1 RDH14 PDCD11 NUP188 TFG	6.59e-04	457	80	6	32344865
Pubmed	The expression pattern of nuclear receptors during cerebellar development.	NR2F1 NR2F2	6.95e-04	17	80	2	17205580
Pubmed	Complementary quantitative proteomics reveals that transcription factor AP-4 mediates E-box-dependent complex formation for transcriptional repression of HDM2.	NGEF NR2F1 NR2F2	7.58e-04	77	80	3	19505873
Pubmed	Comprehensive binary interaction mapping of SH2 domains via fluorescence polarization reveals novel functional diversification of ErbB receptors.	ABL1 FES VAV3	7.58e-04	77	80	3	22973453
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	USP34 BPTF RIF1 PDCD11 NUP188 ASCC3 RPL4	7.74e-04	653	80	7	22586326
Pubmed	Functional screen identifies regulators of murine hematopoietic stem cell repopulation.	ARHGEF5 ADGRG1	7.81e-04	18	80	2	26880577
Pubmed	COMMD1 is linked to the WASH complex and regulates endosomal trafficking of the copper transporter ATP7A.	COMMD7 COMMD10	8.71e-04	19	80	2	25355947
Pubmed	Structure of the endosomal Commander complex linked to Ritscher-Schinzel syndrome.	COMMD7 COMMD10	8.71e-04	19	80	2	37172566
Pubmed	AMPK, a Regulator of Metabolism and Autophagy, Is Activated by Lysosomal Damage via a Novel Galectin-Directed Ubiquitin Signal Transduction System.	FARSB PDCD11 NUP188 ASCC3 TFG RPL4	8.87e-04	484	80	6	31995728
Pubmed	Proteomic analysis of the epidermal growth factor receptor (EGFR) interactome and post-translational modifications associated with receptor endocytosis in response to EGF and stress.	LRRC40 VAV3 RPL4 MRPL9 CDK5	9.11e-04	323	80	5	24797263
Pubmed	CCDC22 deficiency in humans blunts activation of proinflammatory NF-κB signaling.	COMMD7 COMMD10	9.66e-04	20	80	2	23563313
Pubmed	COMMD1 (copper metabolism MURR1 domain-containing protein 1) regulates Cullin RING ligases by preventing CAND1 (Cullin-associated Nedd8-dissociated protein 1) binding.	COMMD7 COMMD10	9.66e-04	20	80	2	21778237
Pubmed	Defects of pelage hairs in 20 mouse mutations.	TMEM79 PMEL	9.66e-04	20	80	2	7738386
Pubmed	Interactions of the Antiviral Factor Interferon Gamma-Inducible Protein 16 (IFI16) Mediate Immune Signaling and Herpes Simplex Virus-1 Immunosuppression.	PDCD11 DDX60L NUP188 ASCC3 TFG	1.03e-03	332	80	5	25693804
Pubmed	The ERAP2 gene is associated with preeclampsia in Australian and Norwegian populations.	ERAP1 NR2F1	1.07e-03	21	80	2	19578876
Pubmed	Coup-TF1 and Coup-TF2 control subtype and laminar identity of MGE-derived neocortical interneurons.	NR2F1 NR2F2	1.07e-03	21	80	2	28694260
Pubmed	Three-dimensional visualization of testis cord morphogenesis, a novel tubulogenic mechanism in development.	RIF1 PEPD LRRC40 NR2F2	1.11e-03	196	80	4	19334288
Pubmed	Interactome of the Autoimmune Risk Protein ANKRD55.	FARSB PDCD11 RPL4 CDK5	1.13e-03	197	80	4	31620119
Pubmed	Identification of endogenous retinoids, enzymes, binding proteins, and receptors during early postimplantation development in mouse: important role of retinal dehydrogenase type 2 in synthesis of all-trans-retinoic acid.	NR2F1 NR2F2	1.17e-03	22	80	2	10753524
Pubmed	A signature motif mediating selective interactions of BCL11A with the NR2E/F subfamily of orphan nuclear receptors.	NR2F1 NR2F2	1.17e-03	22	80	2	23975195
Pubmed	A quantitative protein interaction network for the ErbB receptors using protein microarrays.	ABL1 FES VAV3	1.19e-03	90	80	3	16273093
Pubmed	Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases.	USP34 USP43	1.28e-03	23	80	2	14715245
Pubmed	The Transcription Factor Foxg1 Promotes Optic Fissure Closure in the Mouse by Suppressing Wnt8b in the Nasal Optic Stalk.	NR2F1 NR2F2	1.40e-03	24	80	2	28729440
Pubmed	Compartmentalization of the SUMO/RNF4 pathway by SLX4 drives DNA repair.	PMS1 PEPD FARSB ASCC3 RPL4	1.42e-03	357	80	5	37059091
GeneFamily	Sodium voltage-gated channel alpha subunits	SCN4A SCN9A	3.59e-04	9	58	2	1203
GeneFamily	COMM domain containing	COMMD7 COMMD10	4.48e-04	10	58	2	979
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	ARHGEF5 NGEF VAV3	1.24e-03	66	58	3	722
GeneFamily	CD molecules\|Integrin alpha subunits	ITGA11 ITGAX	1.50e-03	18	58	2	1160
GeneFamily	Guanylate cyclase receptors\|DENN/MADD domain containing	DENND6B DENND3	2.89e-03	25	58	2	504
GeneFamily	SH2 domain containing	ABL1 FES VAV3	4.18e-03	101	58	3	741
Coexpression	MENON_FETAL_KIDNEY_0_CAP_MESENCHYME_CELLS	BPTF RIF1 LYPD1 NR2F1 NR2F2	8.37e-06	90	80	5	M39250
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_C_(IT_L4_RORB)-Exc_L3-4_RORB_RPS3P6\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ITGA11 SCN7A SCN9A LAMA3 VAV3 IL1RAP	1.04e-06	185	80	6	10da5c2a92bfb3248d3f6f94a0933996326cf590
ToppCell	COVID-19_Mild-NK_CD56bright\|COVID-19_Mild / Disease condition and Cell class	SCN9A FES VAV3 TTLL10 ITGAX	1.78e-05	179	80	5	90e7a4af195aa2332b07a9f06cde63e72ff49255
ToppCell	LPS-IL1RA\|World / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	UBD GPR84 DDX60L ASCC3 IL1RAP	2.03e-05	184	80	5	c066c2ec4f0f1d6eb183fca5c7bb0cd45c9950dc
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	NDNF LYPD1 ARHGAP36 SCN7A NR2F2	2.09e-05	185	80	5	08fad1e3c3cc5f1c3eb6629a49c094b628e75a92
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1_VIP_PRSS8\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	NDNF ARHGAP36 SCN7A LAMA3 NR2F2	2.14e-05	186	80	5	fef543f188edb0d1704d9c6ace366a0f8017bf53
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_2\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	NDNF LYPD1 ARHGAP36 LAMA3 NR2F2	2.20e-05	187	80	5	ae2ee6f8e5c37cb88a67f3e742cf86e57657bfaf
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_PAX6\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	NDNF LYPD1 LACC1 SCN7A NR2F2	2.20e-05	187	80	5	d2ffb2f34f07b0dd5d3cb3ee0275f46ebecf4146
ToppCell	Fetal_29-31_weeks-Immune-monocyte-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	FES VAV3 IL1RAP ITGAX DENND3	2.37e-05	190	80	5	ad297172a74a80ed5c10f921e15efd1da0fd2d6b
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_C_(IT_L4_RORB)-Exc_L4_RORB_BHLHE22\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	LINGO1 SCN9A LAMA3 VAV3 IL1RAP	2.49e-05	192	80	5	25460ca9ebd3d49f666394cf99ab77a5e8f77250
ToppCell	3'-Distal_airway-Immune_Myeloid-Myeloid_macrophage-elicited_macrophage-Monocyte-derived_macrophage-Monocyte-derived_macrophage_L.1.2.3.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	GPR84 DDX60L IL1RAP HPSE ITGAX	2.62e-05	194	80	5	3ef9e88e66f2f2ae95dcc834ea605c40c60783fc
ToppCell	Mild-NK\|Mild / Disease group and Cell class	FES ADGRG1 VAV3 TTLL10 ITGAX	2.68e-05	195	80	5	be88a7507cd6a0a9dfe424312d9365039eef7b74
ToppCell	Parenchymal-10x5prime-Epithelial-Epi_airway_ciliated-Deuterosomal\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	NPSR1 NGEF MUC16 ODAD2 TTLL10	2.68e-05	195	80	5	e525b69145059b66417589601f7109af63730f3a
ToppCell	normal_Lymph_Node-T/NK_cells-NK\|normal_Lymph_Node / Location, Cell class and cell subclass	FES USP43 ADGRG1 TTLL10 ITGAX	2.75e-05	196	80	5	00ab4a1547752d419aa720b39b94a4ab2ede963a
ToppCell	VE-NK\|VE / Condition, Cell_class and T cell subcluster	FES ADGRG1 VAV3 TTLL10 ITGAX	2.82e-05	197	80	5	cae6ff8763501e7a5897b50188ac2640d65a47c0
ToppCell	normal_Lung-Endothelial_cells-Lymphatic_ECs\|Endothelial_cells / Location, Cell class and cell subclass	SCN9A PEPD RPL4 NR2F1 NR2F2	2.82e-05	197	80	5	c838d0f64e3b43a616a9e381b8139bfe9aa32da7
ToppCell	VE-NK-\|VE / Condition, Cell_class and T cell subcluster	FES ADGRG1 VAV3 TTLL10 ITGAX	2.82e-05	197	80	5	ee89b8521fb4faaed9e4d39f7171e45eccf38b00
ToppCell	normal_Lymph_Node-T/NK_cells-NK\|T/NK_cells / Location, Cell class and cell subclass	FES USP43 ADGRG1 TTLL10 ITGAX	2.89e-05	198	80	5	75e94298bf03d755fef46df685437d0d29fdbca9
ToppCell	Bronchial-10x5prime-Stromal-Fibroblastic-Fibro_immune_recruiting\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	UBD SCN7A LAMA3 NR2F1 NR2F2	2.96e-05	199	80	5	0cdbedf09ec72734b86ddab3fec562e066afed92
ToppCell	Bronchial-10x5prime-Stromal-Peri/Epineurial_-NAF_epineurial\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	SCN7A NGEF SCN9A NR2F1 NR2F2	2.96e-05	199	80	5	a13f4b8a039304e685464cc8879659824cad5a3e
ToppCell	Neuronal-Inhibitory-iA-iA_1(SST_PAX6)-PAX6-TSPAN12-L1-2\|Neuronal / cells hierarchy compared to all cells using T-Statistic	NDNF ARHGAP36 SCN7A LAMA3 NR2F2	3.03e-05	200	80	5	523d799eb315b33b77e02d5b7db63dad8450c4e1
ToppCell	Tracheal-10x5prime-Stromal-Fibroblastic-Fibro_peribronchial\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	NDNF APCDD1 UBD SCN7A NR2F1	3.03e-05	200	80	5	8ab0051544ea32eb8b3f7f8ba7582deaf8bf26c0
ToppCell	Neuronal-Inhibitory-iA-iA_1(SST_PAX6)-PAX6-TSPAN12\|Neuronal / cells hierarchy compared to all cells using T-Statistic	NDNF ARHGAP36 SCN7A LAMA3 NR2F2	3.03e-05	200	80	5	e5cef95e563a6e793ade190ce88c999bfa0af460
ToppCell	Sigmoid-ILC\|Sigmoid / Region, Cell class and subclass	UBD RBMS1 GYS2 FES TTLL10	3.03e-05	200	80	5	dfb06821f1019833f5d81f9c93808219b5fef407
ToppCell	Neuronal-Inhibitory-iA-iA_1(SST_PAX6)-PAX6\|Neuronal / cells hierarchy compared to all cells using T-Statistic	NDNF LYPD1 LACC1 SCN7A NR2F2	3.03e-05	200	80	5	8a8f9d9e5ffab3f736c4bd0a5bb616d442d137d1
ToppCell	Sigmoid-(3)_ILC\|Sigmoid / shred on region, Cell_type, and subtype	UBD RBMS1 GYS2 FES TTLL10	3.03e-05	200	80	5	a7326c43987a5eb4f4f5b48c4252cf4870432e5d
ToppCell	Sigmoid-(3)_ILC-(30)_ILC\|Sigmoid / shred on region, Cell_type, and subtype	UBD RBMS1 GYS2 FES TTLL10	3.03e-05	200	80	5	c39de94623383da7b2b260eb016ddaa5da7f4350
ToppCell	COVID-19_Mild-NK\|COVID-19_Mild / Disease condition and Cell class	FES ADGRG1 VAV3 ITGAX DENND3	3.03e-05	200	80	5	b586b0f1127293c2f8529be16b24229359041da2
ToppCell	Sigmoid-ILC-ILC\|Sigmoid / Region, Cell class and subclass	UBD RBMS1 GYS2 FES TTLL10	3.03e-05	200	80	5	4ac1e6d7f358003e2448eb69e545772cd261c55f
ToppCell	frontal_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Rspo1_Itga4\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	LYPD1 SCN7A VAV3 NR2F2	1.32e-04	144	80	4	7de962346ba9653d90dd13bb7d977fe44d200bba
ToppCell	PND14-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP1-CAP1_prolif\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	GYS2 SCN7A CTDP1 ZRANB3	1.39e-04	146	80	4	2d907e50206c4762a8baa741363bc7f0a04bd84e
ToppCell	primary_visual_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Rspo1_Itga4\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	LYPD1 SCN7A VAV3 NR2F2	1.75e-04	155	80	4	cba6f3f7742b4d5d54ad0a0ac0dd4016e73fe658
ToppCell	PND01-Immune-Immune_Myeloid-Megakaryocyte/Platelet-Megakaryocyte/Platelet\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	LYPD1 VAV3 HPSE ZRANB3	2.02e-04	161	80	4	52556b89808e551540f33a13f57417a6696c2438
ToppCell	primary_visual_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Crispld2_Kcne4\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	LYPD1 SCN7A LAMA3 NR2F2	2.02e-04	161	80	4	be77e99faf653480c166305df3a4e93db76f0dcb
ToppCell	PND01-Immune-Immune_Myeloid-Megakaryocyte/Platelet-Megakaryocyte/Platelet-Megakaryocyte/Platelet_mature\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	LYPD1 VAV3 HPSE ZRANB3	2.02e-04	161	80	4	54f156cf2bd5a6ba9a78ec4e3ee28b89998aec2e
ToppCell	PND01-Immune-Immune_Myeloid-Megakaryocyte/Platelet\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	LYPD1 VAV3 HPSE ZRANB3	2.02e-04	161	80	4	242891be849a4398fe8bea44875ae1ba57950944
ToppCell	390C-Lymphocytic-ILC\|390C / Donor, Lineage, Cell class and subclass (all cells)	LRRC66 CD101 TONSL HPSE	2.17e-04	164	80	4	b0fc63b72162b5cc4d1e0a271a12f3d3ab29398f
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L1-3_VIP_CCDC184\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	LYPD1 LAMA3 HPSE NR2F2	2.32e-04	167	80	4	ef3ef83c213e818597600da15764c5b37763d7b6
ToppCell	Control-Myeloid-MoAM1,_IL1R2\|Control / Condition, Lineage and Cell class	UBD LACC1 HPSE DENND3	2.32e-04	167	80	4	ab6029ba037b6a499da8758864c44e174cde5587
ToppCell	droplet-Heart-nan-24m-Hematologic-coronary_vascular_endothelial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TONSL CTDP1 ZRANB3 DENND3	2.32e-04	167	80	4	bad33497ceeab968a7eb8a48b921c6f936390743
ToppCell	COVID-19-Heart-Neuronal\|COVID-19 / Disease (COVID-19 only), tissue and cell type	APCDD1 SCN7A SCN9A IL1RAP	2.38e-04	168	80	4	88c2c574f428c2502b5fe099bd73b0758f668ef6
ToppCell	Control-NK\|Control / Disease group and Cell class	FES TTLL10 ITGAX DENND3	2.38e-04	168	80	4	683d389c8a1e791bfc773e63148115a21a6566db
ToppCell	primary_visual_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Pygm_C1ql1\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	LYPD1 SCN7A LAMA3 NR2F2	2.38e-04	168	80	4	f3879a8e11eaf866f37c52e67021be43f0b8784a
ToppCell	10x5'v1-week_12-13-Myeloid_DC-DC-DC1\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	CLCN4 LACC1 PAQR8 VAV3	2.43e-04	169	80	4	319511ea57bbd72c2d95e8516d093689df67a912
ToppCell	5'-Adult-SmallIntestine-Hematopoietic-T_cells-ILC3\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	UBD LACC1 FES GPR84	2.43e-04	169	80	4	d4a0bd792bddfa34332d7dc432ce253f50d98c6f
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.0.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	USP43 MUC16 ODAD2 TTLL10	2.43e-04	169	80	4	14aadc2d1bf66eb47dac33b4d61ddb3c942caa4f
ToppCell	3'-GW_trimst-1-SmallIntestine-Mesenchymal-Pericytes-angiogenic_pericyte\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	LYPD1 LINGO1 NR2F1 NR2F2	2.49e-04	170	80	4	d9ed257d0938442d0bb280e4c4b0c9b657511b46
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Degenerative_Podocyte\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	NDNF LINGO1 HHIPL1 NCDN	2.54e-04	171	80	4	f047a0cc2ce0a062ec502aa9cb91b1202f437f29
ToppCell	390C-Lymphocytic-ILC\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	LRRC66 CD101 TONSL HPSE	2.54e-04	171	80	4	70963f79711fe6088d6d01b29206b17ab89e5e73
ToppCell	10x3'2.3-week_17-19-Myeloid_DC-DC-tDC\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	ZAN SCN9A HHIPL1 LILRA4	2.54e-04	171	80	4	b327fb7813a3cdae06c8a4f8a0c256e9a20132f6
ToppCell	facs-Thymus-Flowthrough-3m-Myeloid\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ELMOD3 IL1RAP ZRANB3 DENND3	2.60e-04	172	80	4	356a66cd9303470e427005cc67fdd22a2c4bf971
ToppCell	facs-Thymus-Flowthrough-3m-Myeloid-macrophage\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ELMOD3 IL1RAP ZRANB3 DENND3	2.60e-04	172	80	4	46fadeee483fdf8402df92ec98575a09c6c15b16
ToppCell	facs-Thymus-Flowthrough-3m-Myeloid-macrophage\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ELMOD3 IL1RAP ZRANB3 DENND3	2.60e-04	172	80	4	438d2e7f1897668a14d85ca70722e5d0102606dc
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c08-IL2RB\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	FES ADGRG1 VAV3 ITGAX	2.60e-04	172	80	4	e3a8891694343b6b01e80a200ae338d24797e417
ToppCell	COPD-Lymphoid-ILC_A\|Lymphoid / Disease state, Lineage and Cell class	CTDP1 FES VAV3 ITGAX	2.66e-04	173	80	4	4a0043b29f8ede5a74bdb38cbf2c70e12b25e130
ToppCell	3'-Distal_airway-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.3.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	NGEF USP43 ODAD2 TTLL10	2.66e-04	173	80	4	c3762655caa79ac4879876f470d32578a3c93b01
ToppCell	ILEUM-inflamed-(1)_T_cell-(1)_T_(gd)\|(1)_T_cell / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	ZAN USP43 VAV3 ITGAX	2.66e-04	173	80	4	62f2f42f54c9c6941bf888956be40230f92c883e
ToppCell	3'-GW_trimst-2-LargeIntestine-Mesenchymal-fibroblastic-Stromal_3_(KCNN3+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	APCDD1 SCN7A CTDP1 CRY1	2.72e-04	174	80	4	9d22a554617a93701d0945de63cc3e7b24322c40
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L5-6_PVALB_FAM150B\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	UBD GYS2 SCN7A VAV3	2.78e-04	175	80	4	29a4197ad4b2382257d7cc9ff237726bb60bc06d
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_PAX6-Inh_L1_PAX6_GRIP2\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	NDNF SCN7A LAMA3 NR2F2	2.78e-04	175	80	4	0c648e7f67ffbe3b476a2ca77d246554f8cd1882
ToppCell	AT1-AT2_cells-IPF_04\|World / lung cells shred on cell class, cell subclass, sample id	NDNF LYPD1 UBD ADGRG1	2.84e-04	176	80	4	f86832cfeff5b3cfffe4455c1b96a1420d48ba1e
ToppCell	P03-Epithelial-airway_epithelial_cell-ciliated_cell_of_airway\|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	SLC17A2 NDNF LAMA3 DENND3	2.84e-04	176	80	4	f3a54038cde58326f1caed96ecca33c141bcc8b3
ToppCell	356C-Fibroblasts-Fibroblast-C_(Myofibroblast)-\|356C / Donor, Lineage, Cell class and subclass (all cells)	ITGA11 SCN7A NR2F1 NR2F2	2.90e-04	177	80	4	cdfd2f0ee2f692271b1525e414b0f645cdadb1f6
ToppCell	356C-Fibroblasts-Fibroblast-C_(Myofibroblast)\|356C / Donor, Lineage, Cell class and subclass (all cells)	ITGA11 SCN7A NR2F1 NR2F2	2.90e-04	177	80	4	db222faaecbe5600da39277243c4e7e764eb63c9
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_PAX6-Inh_L1_PAX6_CA4\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	NDNF LACC1 SCN7A NR2F2	2.96e-04	178	80	4	e86ed30652c2de70f16430f04b78789b87df4af2
ToppCell	3'-Parenchyma_lung-Endothelial-Lymphatic_EC-endothelial_cell_of_lymphatic_vessel-Lymphatic_EC_differentiating-Lymphatic_EC_differentiating_L.2.5.1.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SCN9A VAV3 NR2F1 NR2F2	2.96e-04	178	80	4	ad3de3e03a401dac64431a541899445262246347
ToppCell	droplet-Heart-4Chambers-21m-Mesenchymal-nan\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PMS1 PSMG2 TLCD3A NR2F1	3.03e-04	179	80	4	b44e2d53b82c3c141bfc6539054b19708200a0d9
ToppCell	COVID-19-Heart-Lymph_EC\|Heart / Disease (COVID-19 only), tissue and cell type	SCN9A VAV3 NR2F1 NR2F2	3.03e-04	179	80	4	411620201a860716a8773b92f50f7b94ef34a586
ToppCell	Somatosensory_Cortex_(S1)\|World / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	RBMS1 LAMA3 VAV3 IL1RAP	3.03e-04	179	80	4	82348bf56a4525b2f485696cab5b2ea6e96c2f91
ToppCell	3'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.3.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	NGEF DENND6B USP43 TTLL10	3.09e-04	180	80	4	92fb01b91261b3103454924cde56add337b41844
ToppCell	saliva-Severe-critical_progression_d28-40-Myeloid-Granulocytic-Neutrophil-Neu_c6-FGF23\|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)	PAQR8 HHIPL1 ITGAX DENND3	3.09e-04	180	80	4	cf7d8bf9eee2dfab2c8a6780e296b05ad42041bf
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_PAX6\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	NDNF LACC1 SCN7A NR2F2	3.16e-04	181	80	4	03a303cd2f366f09c18b118bbba6f5e3f95ad56c
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1_ADARB2_ADAM33\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	NDNF LYPD1 ARHGAP36 NR2F2	3.16e-04	181	80	4	2f3d04d22d4ac016e61709ea5af3d48885c946c4
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	NDNF LYPD1 ARHGAP36 NR2F2	3.22e-04	182	80	4	7dc61e901428cea04f00ebb0939a44d21a6145c6
ToppCell	PND14-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1-AT1_mature\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SLC17A2 NDNF TMEM79 LAMA3	3.22e-04	182	80	4	573771130247e869e4e58f22d4a1cb31989635cf
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L1-3_VIP_ZNF322P1\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	LYPD1 LAMA3 HPSE NR2F2	3.22e-04	182	80	4	d3a037268f026eb2f84428b1821022503cef7756
ToppCell	PND14-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SLC17A2 NDNF TMEM79 LAMA3	3.22e-04	182	80	4	6cfaa2b3b3974c13b01c943f4adb70768dcc35e4
ToppCell	TCGA-Prostate-Primary_Tumor-Prostate_Adenocarcinoma-Acinar_Adenocarcinoma-7\|TCGA-Prostate / Sample_Type by Project: Shred V9	TMEM69 FARSB TFG NCDN	3.22e-04	182	80	4	af16334fec2c757b03c84cf252d00e92fa81e4cd
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	NDNF LYPD1 ARHGAP36 NR2F2	3.29e-04	183	80	4	e3ffef2b57dc5b96466dccc9cd54ba326ccf378a
ToppCell	368C-Lymphocytic-CD4_T-cell-Treg_cell_2\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	CD101 RDH14 FES CDK5	3.29e-04	183	80	4	fef51dcf180e6d4e136362c7e140ec5ef372e6d0
ToppCell	AT1-AT2_cells-Donor_02\|World / lung cells shred on cell class, cell subclass, sample id	GHRHR NDNF LAMA3 DENND3	3.29e-04	183	80	4	6821dca076318115d360ff426eb1218cfe104063
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_C_(IT_L4_RORB)\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SCN9A LAMA3 VAV3 IL1RAP	3.36e-04	184	80	4	6475a43201b136dcc9b113d2ca4cfa154ed9d65d
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	NDNF ARHGAP36 SCN7A NR2F2	3.43e-04	185	80	4	16e9ccea0e3b95d90dc48ef74206c805681dac0b
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1_ADARB2_ADAM33\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	NDNF ARHGAP36 SCN7A NR2F2	3.43e-04	185	80	4	487fa382232564f075960899d50afa0edae5d258
ToppCell	Brain_organoid-organoid_Kanton_Nature\|Brain_organoid / Sample Type, Dataset, Time_group, and Cell type.	BPTF ADGRG1 NR2F1 NR2F2	3.43e-04	185	80	4	857c7ca8493e91ef1d0078ddafd6082020f9b169
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_PAX6\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	NDNF LACC1 SCN7A NR2F2	3.43e-04	185	80	4	79cff4f3c6ae8e5ea60e8eae082b9275f2679ee9
ToppCell	Control-Lymphoid-ILC_A\|Lymphoid / Disease state, Lineage and Cell class	CTDP1 FES VAV3 TTLL10	3.43e-04	185	80	4	520795866d44def5be3910ce8e728045c716a24d
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1_VIP_PRSS8\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	NDNF SCN7A LAMA3 NR2F2	3.43e-04	185	80	4	4c42bd3cd72f91f4d4ebb849069a03761a2cd662
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_C_(IT_L4_RORB)-Exc_L4_RORB_CCDC168\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ITGA11 RBMS1 VAV3 IL1RAP	3.43e-04	185	80	4	5a0340c25196453f19e424d346efbf66d2c53ac3
ToppCell	PBMC-Control-cDC_10\|Control / Compartment, Disease Groups and Clusters	LYPD1 APCDD1 UBD ODAD2	3.43e-04	185	80	4	4b5a7450fed912f340da16065c1e65d626dbe8d1
ToppCell	Mild-NK\|World / Disease group and Cell class	FES ADGRG1 TTLL10 ITGAX	3.43e-04	185	80	4	0565b7c464e1a09e596f5a0b363d2dc9b55c3c50
ToppCell	5'-GW_trimst-2-LymphNode-Mesenchymal-Pericytes\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	LYPD1 LINGO1 LAMA3 NR2F2	3.50e-04	186	80	4	1e3ab663e4756975db6d802b2c6c054a94a79393
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	LINGO1 NGEF USP43 DENND3	3.50e-04	186	80	4	84ba666237c18189d7e7556bd92dd953af733c00
ToppCell	COVID_vent-Myeloid-Dendritic\|COVID_vent / Disease condition, Lineage, Cell class and subclass	LACC1 SCN9A FES ITGAX	3.50e-04	186	80	4	63a5cdd3f60681762a218be32db84be8f29b88fd
ToppCell	3'-GW_trimst-1-LargeIntestine-Mesenchymal-Pericytes-Immature_pericyte\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	LYPD1 LINGO1 APCDD1 NR2F2	3.50e-04	186	80	4	db4d9ac89cc1e55062ba888b3410b773340595dd
ToppCell	COVID_vent-Myeloid-Dendritic-cDC\|COVID_vent / Disease condition, Lineage, Cell class and subclass	LACC1 SCN9A FES ITGAX	3.50e-04	186	80	4	39457a7b43537f2c3e221f9375c95d4515424d7d
ToppCell	3'-GW_trimst-1-LargeIntestine-Mesenchymal-Pericytes-Contractile_pericyte_(PLN+)\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	LYPD1 LINGO1 NR2F1 NR2F2	3.57e-04	187	80	4	d52f7bc0afcdc366b20d199ab33c4ec60ed22a68
ToppCell	5'-GW_trimst-1.5-LargeIntestine-Mesenchymal-Pericytes-Immature_pericyte\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	LYPD1 LINGO1 APCDD1 NR2F2	3.57e-04	187	80	4	6820bfbe552ea5e62cfe699687b051a17d9fda61
ToppCell	human_hepatoblastoma-Tumor_cells-T2\|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)	SLC17A2 RBMS1 TBCK NGEF	3.57e-04	187	80	4	f3e37c18ac6471c7992609bbddfa4975571c815c
ToppCell	Fetal_29-31_weeks-Immune-interstitial_macrophage_(C1Q_positive)-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	FES VAV3 IL1RAP ITGAX	3.64e-04	188	80	4	3be2d50148daa4eddddc2c7f269f45c97f7e4931
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_PAX6-Inh_L1_PAX6_CA4\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	NDNF LYPD1 LACC1 NR2F2	3.64e-04	188	80	4	ee572246e0c2f41bdbc29a03edc67b831af95c09
Drug	PbTx-1	UBD SCN4A SCN7A SCN9A	2.33e-06	27	80	4	CID006437089
Disease	generalized epilepsy with febrile seizures plus 2 (implicated_via_orthology)	SCN4A SCN7A SCN9A	2.19e-06	10	79	3	DOID:0111294 (implicated_via_orthology)
Disease	Dravet syndrome (implicated_via_orthology)	SCN4A SCN7A SCN9A	2.19e-06	10	79	3	DOID:0080422 (implicated_via_orthology)
Disease	generalized epilepsy with febrile seizures plus (implicated_via_orthology)	SCN4A SCN7A SCN9A	3.99e-06	12	79	3	DOID:0060170 (implicated_via_orthology)
Disease	Skin Ulcer	PEPD LAMA3	4.23e-05	4	79	2	C0037299
Disease	peak expiratory flow	LINGO1 APCDD1 RBMS1 SCN4A TBCK RDH14 PAQR8	3.80e-04	498	79	7	EFO_0009718
Disease	amyotrophic lateral sclerosis	RBMS1 SCN7A COMMD10 LAMA3	6.32e-04	145	79	4	MONDO_0004976
Disease	epilepsy (implicated_via_orthology)	SCN4A SCN7A SCN9A CDK5	9.77e-04	163	79	4	DOID:1826 (implicated_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
TALGAKILTRLVLSP	CTDP1	661	Q9Y5B0
KRIQPTIRRTGLAAL	ELMOD3	121	Q96FG2
QLKRIFRLLGTPTEE	CDK5	211	Q00535
LKSFLILPFQRITRL	ARHGEF5	1306	Q12774
IGLILSRARKLPIAT	GYS2	186	P54840
LKLRRILNLSPFTVT	CLCN4	691	P51793
KSLVLVSRLPFVRLF	DENND6B	151	Q8NEG7
TTTFLLRRIPTLKIR	DENND3	771	A2RUS2
RTPLQQSTLGKAIIR	BPTF	2191	Q12830
LTSQKPSVLLTLRGV	PEPD	136	P12955
LKPFGQVISTRILRD	RBMS1	161	P29558
EPTTLLQRLRGTISK	RFX5	26	P48382
LQLSKISFPIGQRLL	ARHGAP36	206	Q6ZRI8
RFGKLLLRLPSLRTV	NR2F1	366	P10589
GKLLLRLPSLRTVSS	NR2F2	361	P24468
PSVRLKIASLLGLLS	INTS4	86	Q96HW7
TLRLNFTLVGKPLLA	ITGAX	731	P20702
VLQGLLRPLFKNTSV	MUC16	13821	Q8WXI7
LVSGVSRKPSLLTLQ	LILRA4	216	P59901
KLVFSIRPRSLTGIL	LAMA3	3181	Q16787
VLNKIPILSTFLTAR	NCDN	126	Q9UBB6
LFSIPTLIIFGKRTL	NPSR1	176	Q6W5P4
SRLGKPFLNISRVVL	HHIPL1	226	Q96JK4
SFIQKSRRLLVVLSP	IL1RAP	456	Q9NPH3
NTILEFLPKQRRTGL	DDX55	186	Q8NHQ9
IKRLLASSVPELRGQ	DDX60L	1331	Q5H9U9
DTGRFPRLLTRILQK	COMMD10	26	Q9Y6G5
LQKGFPLITITVRGR	ERAP1	526	Q9NZ08
TFLRSLPALRGKLTI	LACC1	166	Q8IV20
LPALRGKLTIITSSL	LACC1	171	Q8IV20
LLFPLSSRTQKLPTR	NDNF	11	Q8TB73
LRSNRLKLIPLGVFT	LINGO1	126	Q96FE5
ARSVVRRIGTNLPLK	MTFR1L	21	Q9H019
KITIPIATRSGNRLL	ITGA11	1006	Q9UKX5
FRNIPGITLLNVSKL	RPL4	221	P36578
TLLALAIQPKLRTRF	GPR84	41	Q9NQS5
FLILLGSPKLRTLAR	HPSE	71	Q9Y251
SSFRNRFPLLKVLIL	LRRC66	141	Q68CR7
TLSVSGQQLRRLPKI	PAQR8	11	Q8TEZ7
KLGPTTFRLSIERLQ	CD101	226	Q93033
LRKLNSRLFVIRGQP	CRY1	66	Q16526
GSLRSIVKSLLLVPN	COMMD7	66	Q86VX2
AFIPLISTRVSLRKT	ABL1	1001	P00519
SVLLPRTLFQRTKGR	ADGRG1	266	Q9Y653
TNPTYTLIIRGKIRL	APCDD1	116	Q8J025
RLSKSTLFLIPLFGI	GHRHR	326	Q02643
LRPGLRTTILFLKLA	LYPD1	121	Q8N2G4
TTVTALRLFKNLPVR	PMS1	141	P54277
PKLVLQSLFSLIRGE	CNST	166	Q6PJW8
LKFLALEGNPLRTIR	LRRC40	336	Q9H9A6
SGPLSKLSLLIRERQ	FES	96	P07332
FRVLRALKTITVIPG	SCN4A	221	P35499
IRKIFATLTRPLALF	RIF1	851	Q5UIP0
LLFLSVPQIKIRSFG	ODAD2	91	Q5T2S8
VPQIKIRSFGQLSRL	ODAD2	96	Q5T2S8
SSFLILPFQRITRLK	NGEF	406	Q8N5V2
FRVLRALKTISVIPG	SCN9A	216	Q15858
PVGLRTSRTDILSLK	TMEM69	21	Q5SWH9
LGLLKSSAPSRIVVV	RDH14	176	Q9HBH5
PLLDGTATLRLVKRQ	PMEL	456	P40967
EFQVARTTLLPGLLK	FARSB	446	Q9NSD9
KPVLIFVSSRRQTRL	ASCC3	1556	Q8N3C0
LVSVKKSLGRNRLLP	MRPL9	111	Q9BYD2
GRIPLLLTSLSFKVL	PDCD11	1176	Q14690
LLGSKILKPRRSLSS	UBD	51	O15205
PLQGTLTLLRSVFRK	USP43	991	Q70EL4
SRILKLTLFVNGQPR	TFG	81	Q92734
LRTRKGLSPLETLQQ	TONSL	626	Q96HA7
STPFVSLGRVLIQLK	TLCD3A	156	Q8TBR7
LLRLITVRKLFSSLG	SLC17A2	341	O00624
KLLPLLTGLFAVSRL	TMEM79	311	Q9BSE2
PLLQLLRALVSGKST	NUP188	446	Q5SRE5
LTPNSIKILGRFQIL	TBCK	31	Q8TEA7
PSRKLVALQLRSIFI	PSMG2	81	Q969U7
FIPTLQTARTLRILK	SCN7A	201	Q01118
SVVISLRLLPKLFGT	USP34	916	Q70CQ2
TSQVLDRIKGSLLPR	YIPF2	91	Q9BWQ6
LLTTKIGLLSTLRGR	TTLL10	221	Q6ZVT0
RIIRKSGQLFCSPIL	ZRANB3	801	Q5FWF4
VTLPESTVTLLKGRR	ZAN	1216	Q9Y493
GKVIETLSRLSRTPI	VAV3	106	Q9UKW4
ATFRQLLKLPRTLIL	NAT8	31	Q9UHE5